No records
|
27 |
Koesnoe S., Masjkuri N., Adisasmita A., Djauzi S., Kartasasmita C., Sundoro J., Nadjib M., Korib M., Muthia A.N., Muzellina V.N., Habibah U., Nursyirwan S.A., Djaya K.H., Bachtiar N.S., Sari R.M. |
26028015000;57189271669;22978283200;23495847800;57206248946;49762130000;24401623600;57391576000;57391576100;57223968527;57391443900;57249143800;57392218600;54879388400;57191341371; |
A randomized controlled trial to evaluate the effect of influenza vaccination and probiotic supplementation on immune response and incidence of influenza-like illness in an elderly population in Indonesia |
2021 |
PLoS ONE |
16 |
12 December |
e0250234 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122024701&doi=10.1371%2fjournal.pone.0250234&partnerID=40&md5=6918933f17507c8ed64013b241adb3c2 |
Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Indonesian Society of Internal Medicine, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; PT. Bio Farma, Bandung, Indonesia |
Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Masjkuri, N., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Adisasmita, A., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Djauzi, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Kartasasmita, C., Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Sundoro, J., Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Nadjib, M., Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Korib, M., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Muthia, A.N., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Muzellina, V.N., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Habibah, U., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Djaya, K.H., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Bachtiar, N.S., PT. Bio Farma, Bandung, Indonesia; Sari, R.M., PT. Bio Farma, Bandung, Indonesia |
Aim To investigate the effect of influenza vaccination with or without probiotic supplementation on the immune response and incidence of influenza-like illness (ILI) in the elderly. Methods A randomized double-blind, placebo-controlled trial with a modified factorial design was conducted in 554 healthy elderly subjects aged 67 ± 5.6 (ranging from 60–90) years old in the Primary Health Care Center (Puskesmas area) of the Pulo Gadung District East Jakarta. Subjects received either a trivalent influenza vaccine or placebo at the start of the study, and a probiotic supplement (Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011) or a placebo for 6 months. Subjects were randomly assigned into four intervention groups: influenza vaccine and probiotics (n = 141), influenza vaccine and placebo (n = 136), placebo and probiotics (n = 140), and both placebo (n = 137). The primary outcome was ILI incidence within 6 months. The secondary outcomes were seroprotection and seroconversion rates at 1, 4, and 6 months after administering the interventions. Results This study showed that the trivalent influenza vaccine increased seroprotection (RR 3.6 [95%CI 2.92–4.47]; p<0.010) and seroconversion (RR 29.8 [95%CI 11.1–79.5]; p<0.010) rates 1 month after vaccination in elderly people while the probiotic supplement did not alter influenza antibody titers (p = 1.000 and p = 0.210). The relative ILI incidence risk was similar between vaccinated and non-vaccinated groups, as well as in the probiotic group compared to the non-probiotic group. Conclusion The tested trivalent influenza vaccine significantly induced seroprotection and seroconversion in the vaccinated subjects, while probiotics administration did not influence these parameters. Vaccinated individuals displayed a similarly low ILI incidence as those in the Control Group. However, the observed trend towards a reduction of ILI incidence with probiotics supplementation warrants further assessments in a larger, at-risk population. © 2021 Koesnoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
|
flubio; influenza vaccine; placebo; influenza vaccine; probiotic agent; adult; aged; antibody titer; Article; controlled study; diet supplementation; double blind procedure; drug effect; female; human; immune response; incidence; Indonesia; influenza; major clinical study; male; middle aged; population risk; population structure; primary health care; randomized controlled trial; sample size; seroconversion; treatment duration; treatment outcome; vaccination; very elderly; incidence; influenza; Lactobacillus helveticus; Lactobacillus rhamnosus; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Incidence; Indonesia; Influenza Vaccines; Influenza, Human; Lactobacillus helveticus; Lactobacillus rhamnosus; Male; Middle Aged; Probiotics |
Public Library of Science |
19326203 |
|
34914726 |
Article |
Q1 |
990 |
4434 |
|
|
37 |
Tamin S., Adham M., Noer A., Supriana N., Bardosono S. |
57195719598;14024202100;57370851100;8438653200;21933841000; |
Upright epiglottis prevents aspiration in patients with nasopharyngeal carcinoma post-chemoradiation |
2021 |
PLoS ONE |
16 |
12 December |
e0261110 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121054797&doi=10.1371%2fjournal.pone.0261110&partnerID=40&md5=c09f68482b8e097a20b06089e0d5849e |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Tamin, S., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adham, M., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Noer, A., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Supriana, N., Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
NPC is the most widely found malignant tumor in the head and neck region in Indonesia. Chemoradiation therapy for NPC can induce swallowing disorders (dysphagia) that adversely affects a patients quality of life. This study aimed to assess the swallowing process by flexible endoscopic evaluation of swallowing in patients with nasopharyngeal carcinoma after chemoradiation. Thirty-nine patients with NPC who had chemoradiation therapy more than one month previously underwent flexible endoscopic evaluation of swallowing and were assessed for oral transport time, sensation, standing-secretion, pre-swallowing leakage, residue, penetration, aspiration, and silent aspiration. The most common structural abnormalities were an upright and swollen epiglottis (89.4%), poor oral hygiene, and velopharyngeal closure defects (56.4%). This examination also revealed a mild degree of standing secretion (38.5%) and aspiration (10.3%). No penetration was observed in 64.1% of the patients, and no silent aspiration was observed in any of the patients. A severe degree of residue (45.7%) was observed when administering oatmeal, while the residue was mild to moderate when administering gastric rice, crackers, and milk. The residue changed to a mild degree (32.3%-51.4%) in all food administrations after the watering maneuver. The highest penetration was noted after oatmeal administration (42.8%), and the highest aspiration was found after milk administration (8.6%). Standing secretion in almost all patients was caused by hyposensitivity of the hypopharynx. Persistent residue and hyposensitivity of the hypopharynx led to aspiration. The low percentage of aspiration and silent aspiration might have been caused by the upright and swollen epiglottis that prevented aspiration. Poor oral hygiene and a dry mouth led to prolonged oral transport. Therefore, most patients had hypopharyngeal abnormalities in the form of a swollen and upright epiglottis. Secretion and food residue were also detected. Drinking helps to expedite the swallowing process by facilitating oral phase transport and reducing residues. © 2021 Tamin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
|
acid aspiration; adult; adverse event; chemoradiotherapy; digestive tract endoscopy; dysphagia; female; human; male; middle aged; nasopharynx carcinoma; nasopharynx tumor; pathology; pathophysiology; procedures; Adult; Chemoradiotherapy; Deglutition Disorders; Endoscopy, Digestive System; Female; Humans; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Respiratory Aspiration |
Public Library of Science |
19326203 |
|
34882745 |
Article |
Q1 |
990 |
4434 |
|
|
138 |
Gunardi T.H., Susantono D.P., Victor A.A., Sitompul R. |
57195939686;57353411000;57191055282;8312163900; |
Atopobiosis and dysbiosis in ocular diseases: Is fecal microbiota transplant and probiotics a promising solution? |
2021 |
Journal of Ophthalmic and Vision Research |
16 |
4 |
|
631 |
643 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119915775&doi=10.18502%2fJOVR.V16I4.9754&partnerID=40&md5=8d0e2b295a398c85ff1c28564276103b |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Gunardi, T.H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Susantono, D.P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Victor, A.A., Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sitompul, R., Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: To highlight the role of atopobiosis and dysbiosis in the pathomechanism of autoimmune uveitis, therefore supporting fecal microbiota transplant (FMT) and probiotics as potential targeted-treatment for uveitis. Methods: This review synthesized literatures upon the relation between gut microbiota, autoimmune uveitis, FMT, and probiotics, published from January 2001 to March 2021 and indexed in PubMed, Google Scholar, CrossRef. Results: The basis of the gut-eye axis revolves around occurrences of molecular mimicry, increase in pro-inflammatory cytokines, gut epithelial barrier disruption, and translocation of microbes to distant sites. In patients with autoimmune uveitis, an increase of gut Fusobacterium and Enterobacterium were found. With current knowledge of aforementioned mechanisms, studies modifying the gut microbiome and restoring the physiologic gut barrier has been the main focus for pathomechanism-based therapy. In mice models, FMT and probiotics targeting repopulation of gut microbiota has shown significant improvement in clinical manifestations of uveitis. Consequently, a better understanding in the homeostasis of gut microbiome along with their role in the gut-eye axis is needed to develop practical targeted treatment. Conclusion: Current preliminary studies are promising in establishing a causative gut-eye axis relationship and the possibility of conducting FMT and probiotics as targeted treatment to mitigate autoimmune uveitis, to shorten disease duration, and to prevent further complications. © 2021 GUNARDI ET AL. THIS IS AN OPEN ACCESS ARTICLE DISTRIBUTED UNDER THE CREATIVE COMMONS ATTRIBUTION LICENSE | PUBLISHED BY KNOWLEDGE E |
Atopobiosis; Autoimmune; Dysbiosis; Gut-Eye Axis; Uveitis |
|
Knowledge E |
20082010 |
|
|
Review |
Q3 |
557 |
9058 |
|
|
144 |
Susiloretni K.A., Smith E.R., Suparmi, Marsum, Agustina R., Shankar A.H. |
55920057100;55479658700;57201388096;57203690495;57214141404;7005442634; |
The psychological distress of parents is associated with reduced linear growth of children: Evidence from a nationwide population survey |
2021 |
PLoS ONE |
16 |
10 October |
e0246725 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118229642&doi=10.1371%2fjournal.pone.0246725&partnerID=40&md5=e63e172d790e5a4d43ab7ba273dd42d6 |
Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Department of Global Health, George Washington University, Washington, D.C., United States; National Health Institute Research and Development, Jakarta, Indonesia; Faculty of Medicine, Department of Nutrition, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Nuffield Department of Medicine, The Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom |
Susiloretni, K.A., Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Smith, E.R., Department of Global Health, George Washington University, Washington, D.C., United States; Suparmi, National Health Institute Research and Development, Jakarta, Indonesia; Marsum, Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Agustina, R., Faculty of Medicine, Department of Nutrition, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Shankar, A.H., Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Nuffield Department of Medicine, The Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom |
Background Stunting, an indicator of restricted linear growth, has become a primary measure of childhood undernutrition due to its persistent high prevalence globally, and importance for health and development. Although the etiology is recognized as complex, most analyses have focused on social and biomedical determinants, with limited attention on psychological factors affecting care and nurturing in the home. We assessed whether the psychological distress of parents is related to child linear growth and stunting, and documented the associated risk factors, and examined the relationship between parental distress and behavioral and other risk factors for stunting. Methods We used data from the Indonesia National Health Survey 2013, including 46,315 children 6–59 months of age. Multivariate linear, logistic, and multilevel multinomial logistic regression, using survey weights, were used to assess the relationship between parental distress, as assessed by the WHO Self Reporting Questionnaire (SRQ20), with height-for-age z score (HAZ), stunting, and behavioral and other risk factors for stunting. Results Maternal, paternal and parental distress (i.e. both maternal and paternal distress) were associated with reduced linear growth of the children by 0.086 (95% CI -0.17, -0.00), 0.11 (95% CI -0.24, -0.02) and 0.19 (95% CI -0.37, -0.00) HAZ-scores, respectively. Maternal and paternal distress increased the risk of mild stunting (HAZ <-1) by 33% (95% CI 1.17,1.50) and 37% (95% CI 1.18,1.60), and the risk of moderate stunting (HAZ <-2) by 25% (95% CI 1.10,1.43) and 28% (95% CI 1.08,1.51]), respectively. Parental stress increased the risk of moderate stunting by 40% (95% CI 1.06,1.85). Amongst specific groups of risk factors, the proportion of HAZ-score lost was associated with socioeconomic factors (30.3%) including, low wealth, low maternal occupational status, low maternal education, rural residence, and low paternal occupational status; physiological factors (15.5%) including low maternal height, low maternal mid-upper arm circumference, being male, low paternal height; behavioral factors (8.9%) including open garbage disposal, paternal smoking, not using iodized salt; and experiencing at least one infectious diseases episode (1.1%). Conclusions Maternal, paternal and parental stress were associated with reduced linear growth of children. These findings highlight the complex etiology of stunting and suggest nutritional and other biomedical interventions are insufficient, and that promotion of mental and behavioral health programs for parents must be pursued as part of a comprehensive strategy to enhance child growth and development, i.e. improved caretaker capacity, integrated community development, improved parenting skills, as well as reduced gender discrimination, and domestic violence. © 2021 Susiloretni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
|
sodium chloride; adult; anthropometric parameters; arm circumference; Article; body height; child; child development; child growth; child parent relation; distress syndrome; domestic violence; education; female; health behavior; health program; health survey; height for age z score; human; Indonesia; infant; infection; male; maternal stress; multivariate logistic regression analysis; occupation; parental stress; paternal smoking; paternal stress; physiology; population; risk factor; rural area; Self Reporting Questionnaire 20; sex ratio; sexism; socioeconomics; stunting; waste disposal; wealth distribution; cross-sectional study; distress syndrome; educational status; growth disorder; nutritional status; physiology; preschool child; prevalence; psychology; rural population; Body Height; Ch |
Public Library of Science |
19326203 |
|
34699530 |
Article |
Q1 |
990 |
4434 |
|
|
162 |
Sylvawani M., Setyohadi B., Purnamasari D., Abdullah M., Kurniawan M.R. |
57225078775;6504721711;36519537700;7103393434;57192808936; |
Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus |
2021 |
Journal of Taibah University Medical Sciences |
16 |
5 |
|
719 |
723 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109109686&doi=10.1016%2fj.jtumed.2021.05.007&partnerID=40&md5=4f913f9e9865492b0cdd9860adfea935 |
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sylvawani, M., Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Setyohadi, B., Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Purnamasari, D., Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Abdullah, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kurniawan, M.R., Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia |
Objectives: This study assesses the serum levels of insulin-like growth factor-1 (IGF-1) and sclerostin as markers of decreased bone formation in premenopausal women with type 2 diabetes mellitus. Methods: A cross-sectional study was conducted to measure serum levels of IGF-1 and sclerostin in 40 premenopausal women with and without diabetes mellitus using an enzyme-linked immunosorbent assay. The levels of IGF-1 and sclerostin were compared between the groups using the Mann Whitney test and unpaired t-test, respectively. Results: The median IGF-1 serum levels were 40.60 ng/mL and 42.7 ng/mL in the diabetic and non-diabetic groups, respectively, with no significant difference. The serum levels of sclerostin were significantly higher in the diabetic group than in the non-diabetic group (132.1 pg/mL and 96.0 pg/mL, respectively; p < 0.001). Conclusion: The levels of sclerostin were significantly higher in premenopausal women with diabetes mellitus than in the non-diabetic group. Since sclerostin influences the differentiation and maturation of osteoblasts, serum sclerostin might potentially be useful as a marker of decreased bone formation in premenopausal women with diabetes. © 2021 The Authors |
Diabetes mellitus; IGF-1; Osteoblasts; Premenopause; Sclerostin |
alanine aminotransferase; collagen type 1; creatinine; hemoglobin A1c; insulin; oral antidiabetic agent; sclerostin; somatomedin C; adult; aged; Article; body mass; bone metabolism; cell differentiation; cell maturation; civil servant; comparative study; controlled study; cross-sectional study; diabetic patient; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; housewife; human; major clinical study; non insulin dependent diabetes mellitus; obesity; ossification; osteoblast; premenopause; private sector; protein blood level |
Elsevier B.V. |
16583612 |
|
|
Article |
Q3 |
269 |
15910 |
|
|
206 |
Findyartini A., Greviana N., Hanum C., Husin J.M., Sudarsono N.C., Krisnamurti D.G.B., Rahadiani P. |
56543777300;57197709749;57257072300;57221607411;57201862518;55934951600;55524183700; |
Supporting newly graduated medical doctors in managing COVID-19: An evaluation of a Massive Open Online Course in a limitedresource setting |
2021 |
PLoS ONE |
16 |
9 September |
e0257039 |
|
|
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114841740&doi=10.1371%2fjournal.pone.0257039&partnerID=40&md5=d823d8aaf9a69d130347230f477800d5 |
Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Findyartini, A., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hanum, C., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Husin, J.M., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sudarsono, N.C., Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnamurti, D.G.B., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rahadiani, P., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction Newly graduated medical doctors in their internships are positioned to strengthen the front line in combating COVID-19. We developed a Massive Open Online Course (MOOC) to equip them with adequate knowledge for COVID-19 management. This paper aims to analyze the MOOC and evaluate participant satisfaction and increase in knowledge after completing the course. Methods An observational study was conducted. Quantitative data were obtained from questionnaires and pre-and post-Tests. Responses to open-ended questions of the questionnaires were collected. Analysis using the Quality Reference Framework was also completed. Results The MOOC consisted of fundamental knowledge of COVID-19 (Part A) and further enrichment (Part B), and the content was written in the Indonesian language. A total of 3,424 and 2,462 participants completed the course in August and November 2020, respectively. Most participants agreed that the platform was easy to navigate, the design was interesting, and the content was aligned with their needs. Pre-and post-Test scores in Part A s subjects increased significantly. Factors contributing to and inhibiting usability and areas for improvement were further highlighted. Discussion The use of a specific quality framework facilitated a comprehensive evaluation of the MOOC s strengths, weaknesses, and areas for future improvements. The participants satisfaction and pre-and post-Test results showed that the current MOOC holds great potential benefit for continuing education for medical interns joining the frontliners during the pandemic. Future implementation should consider increasing the quality of learning resources, scaling up the platform and its technical supports, and enhancing organizational supports. © 2021 Public Library of Science. All rights reserved. |
|
education; epidemiology; human; Indonesia; medical education; procedures; program evaluation; questionnaire; COVID-19; Education, Distance; Education, Medical, Graduate; Educational Measurement; Humans; Indonesia; Program Evaluation; Surveys and Questionnaires |
Public Library of Science |
19326203 |
|
34506524 |
Article |
Q1 |
990 |
4434 |
|
|
208 |
Widodo D.W., Mars R., Suwento R., Alviandi W., Oriza I.I.D., Bardosono S. |
56644646600;57248384300;55743638800;57189731254;57205092885;21933841000; |
Satisfaction and health-related quality of life of patients with microtia following reconstructive surgery using the Nagata technique |
2021 |
PLoS ONE |
16 |
9 September |
e0256652 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114383156&doi=10.1371%2fjournal.pone.0256652&partnerID=40&md5=3f7c84ef725b34720da5ae494a0fc02a |
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Widodo, D.W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Mars, R., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Suwento, R., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Alviandi, W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Oriza, I.I.D., Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Objective This study aimed to investigate the functional outcomes, satisfaction, and quality of life of patients with microtia following reconstructive surgery. Methods This cross-sectional study was conducted using retrospective data of patients with microtia following reconstructive surgery using the Nagata technique. Data were obtained from the medical records of patients who underwent reconstructive surgery at the Division of Facial Plastic and Reconstructive Surgery, Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Cipto Mangunkusumo Hospital between 2014 and 2018. All eligible patients were referred to participate in this study between November 2018 and March 2019. The hearing function was assessed by a professional audiologist after surgery. Patient satisfaction was evaluated by interview using a previously developed questionnaire, while quality of life was assessed using the EuroQol-5D-Young questionnaire. Results Thirty-one eligible subjects were included in the study. Pain and discomfort were the most commonly reported factors related to the quality of life following surgery. Approximately 67.7% of the patients were satisfied; 19.4% were very satisfied, and 12.9% reported acceptance of their surgical outcomes. The most common complication was infection (n = 8). Most patients did not experience any problems in their lives after microtia surgery. Conclusions The highest rate of satisfactory outcomes was observed for the lobule subunit, which was assumed to be associated with the use of the Z-plasty technique. The most common complication was infection, as environmental hygiene was the most important factor. Thus, further concern for maintaining good hygiene is necessary to improve the quality of reconstructive surgery. The level of satisfaction with microtia reconstructive surgery was adequate. Most patients had a good health-related quality of life without experiencing any problems. © 2021 Widodo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
|
adolescent; Article; audiologist; child; clinical article; cross-sectional study; ear infection; European Quality of Life 5 Dimensions questionnaire; female; hearing; human; interview; male; medical record; microtia; otalgia; patient referral; patient satisfaction; quality of life; questionnaire; reconstructive surgery; retrospective study; external ear; microtia; patient satisfaction; procedures; psychology; reconstructive surgery; treatment outcome; Adolescent; Child; Congenital Microtia; Cross-Sectional Studies; Ear, External; Female; Humans; Male; Patient Satisfaction; Quality of Life; Reconstructive Surgical Procedures; Retrospective Studies; Treatment Outcome |
Public Library of Science |
19326203 |
|
34469475 |
Article |
Q1 |
990 |
4434 |
|
|
239 |
Sobri F.B., Bachtiar A., Panigoro S.S., Rahmaania J.C., Yuswar P.W., Krisnuhoni E., Tandiari N. |
57217500979;56683183900;56790104300;57252632900;57253490900;35310982200;57252633000; |
Strategy for diagnosing breast cancer in Indonesia during the COVID-19 pandemic: Switching to ultrasound-guided percutaneous core needle biopsy |
2021 |
Kesmas |
16 |
3 |
|
151 |
157 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114650507&doi=10.21109%2fkesmas.v16i3.4359&partnerID=40&md5=dbf4756507a59d7c2f87cc7eb69f6787 |
Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgical Oncology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pathology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Department of Radiology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia |
Sobri, F.B., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia, Department of Surgical Oncology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Bachtiar, A., Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Panigoro, S.S., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmaania, J.C., Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Yuswar, P.W., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Pathology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Tandiari, N., Department of Radiology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia |
In this era of COVID-19, suspected breast cancer patients experience delay in diagnosis due to the fear of contracting the virus and reduction of non-COVID-19 health services. Furthermore, it may lead to potential increase in the incidence of advanced cancers in the future. Ultrasound-guided (US-guided) percutaneous core needle biopsy (CNB) is a great option for the diagnosis of cancer but it is poorly utilized. This study aimed to prove that the US-guided CNB is accurate when performed in a local setting and a potential solution for diagnosing breast cancer patients in this pandemic. In addition, it was a single health center cross-sectional study, and the participants were all breast cancer patients that had US-guided CNB from 2013-2019. The pathology results from US-guided CNB were compared to specimens from post-CNB surgeries. The data were collected from medical records and the immunohistochemistry (IHC) examinations were carried out for malignancy. There were 163 patients who were included in this study, 86 had malignancies and 77 had benign tumor reported in their CNB results. The US-guided CNB had 100% sensitivity and specificity compared to surgery. With its lower cost, time usage, and patient exposure to the hospital environment, US-guided CNB should replace open surgery biopsy for diagnosing suspicious breast cancers during the pandemic in Indonesia. Copyright © 2021, Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal). |
Breast cancer; Core needle biopsy; COVID-19; Health cost; Resources |
|
Universitas Indonesia, Faculty of public health |
19077505 |
|
|
Article |
Q4 |
146 |
23606 |
|
|
245 |
Yunihastuti E., Hariyanto R., Sulaiman A.S., Harimurti K. |
57221273925;57226819413;57216938482;23473513200; |
Hepatitis C continuum of care: Experience of integrative hepatitis C treatment within a human immunodeficiency virus clinic in Indonesia |
2021 |
PLoS ONE |
16 |
8 August |
e0256164 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112781600&doi=10.1371%2fjournal.pone.0256164&partnerID=40&md5=97994b56bdf101c196e7c76dcd7be446 |
Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yunihastuti, E., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hariyanto, R., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sulaiman, A.S., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harimurti, K., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction Direct-acting antiviral drugs (DAAs) have changed the paradigm of hepatitis C therapy for both HCV/HIV co-infected and HCV mono-infected patients. We aimed to describe the HCV continuum of care of HIV-infected patients treated in an HIV clinic after a free DAA program in Indonesia and identify factors correlated with sofosbuvir-daclatasvir (SOF-DCV) treatment failure. Methods We did a retrospective cohort study of adult HIV/HCV co-infected patients under routine HIV-care from November 2019 to April 2020 in the HIV integrated clinic of Cipto Mangunkusumo Hospital, Jakarta, Indonesia. We evaluated some factors correlated with sofosbuvir-daclatasvir treatment failure: gender, diabetes mellitus, previous IFN failure, cirrhosis, concomitant ribavirin use, high baseline HCV-RNA, and low CD4 cell count. Results and discussion Overall, 640 anti-HCV positive patients were included in the study. Most of them were male (88.3%) and former intravenous drug users (76.6%) with a mean age of 40.95 (SD 4.60) years old. Numbers and percentages for the stages of the HCV continuum of care were as follows: HCV-RNA tested (411; 64.2%), pre-therapeutic evaluation done (271; 42.3%), HCV treatment initiated (210; 32.8%), HCV treatment completed (207; 32.2%), but only 178 of these patients had follow-up HCV-RNA tests to allow SVR assessment; and finally SVR12 achieved (178; 27.8%). For the 184 who completed SOF-DCV treatment, SVR12 was achieved by 95.7%. In multivariate analysis, diabetes mellitus remained a significant factor correlated with SOF-DCV treatment failure (adjusted RR 17.0, 95%CI: 3.28–88.23, p = 0.001). Conclusions This study found that in the HCV continuum of care for HIV/HCV co-infected patients, gaps still exist at all stages. As the most commonly used DAA combination, sofosbuvir daclatasvir treatment proved to be effective and well-tolerated in HIV/HCV co-infected patients. Diabetes mellitus was significant factor correlated with not achieving SVR12 in this population. © 2021 Yunihastuti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
|
antiretrovirus agent; daclatasvir; efavirenz; elbasvir plus grazoprevir; interferon; lopinavir plus ritonavir; nevirapine; ribavirin; simeprevir; sofosbuvir; virus RNA; antivirus agent; adult; Article; CD4 lymphocyte count; cohort analysis; coinfection; controlled study; diabetes mellitus; drug withdrawal; fatigue; female; fever; follow up; gastrointestinal disease; gender; headache; hepatitis C; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; Indonesia; injection drug user; liver cirrhosis; major clinical study; male; multivariate analysis; myalgia; nausea; patient care; pruritus; retrospective study; RNA analysis; sleep disorder; sustained virologic response; university hospital; virus load; coinfection; drug effect; Hepacivirus; hepatitis C; |
Public Library of Science |
19326203 |
|
34383853 |
Article |
Q1 |
990 |
4434 |
|
|
259 |
Sekarsari D., Handoyo S., Amal M.Y., Kharismarini P. |
57193342279;57224682258;57221702104;57224681914; |
Necrotizing pneumonia with bronchopleural fistula as an uncommon complication of pneumonia in children: a case report |
2021 |
Radiology Case Reports |
16 |
8 |
|
2077 |
2080 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108157304&doi=10.1016%2fj.radcr.2021.05.008&partnerID=40&md5=599c73e7c6b4ff903fc62bca8efdf6b7 |
Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Sekarsari, D., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Handoyo, S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Amal, M.Y., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Kharismarini, P., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Necrotizing pneumonia is an uncommon but severe complication of community acquired pneumonia characterized by the development of necrosis, liquefaction, and cavitation of the lung parenchyma. It occurs infrequently in children, ranging from 0.8% to 7% of community acquired pneumonia cases. We reported a case of 28-month-old female infant with a history of severe dyspnea and fever 5 days before admission. After administration of appropriate antibiotics for pneumonia, the patient's condition was still unresolved. Then, contrast CT scan showed cavitary lesions within consolidated lungs with loss of volume and lack of contrast enhancement that confirmed the diagnosis as necrotizing pneumonia. The presence of pneumothorax in the patient depicts a possible bronchopleural fistula which significantly increase morbidity and mortality risk. Surgical management could not be implemented due to worsening condition of the patient. It is suggested that patients with suspicion of necrotizing pneumonia are subjected to chest CT scan to avoid delay in diagnosis and appropriate management. © 2021 |
Bronchopleural fistula; Children; Imaging; Necrotizing; Pneumonia |
amikacin; antibiotic agent; cefotaxime; ipratropium bromide plus salbutamol; meropenem; salbutamol sulfate; sulbactam; sultamicillin; abnormal respiratory sound; anemia; antibiotic therapy; Article; atelectasis; blood transfusion; bronchopleural fistula; case report; child; clinical article; computer assisted tomography; contrast enhancement; coughing; cytology; drug substitution; dyspnea; female; fever; follow up; heart arrest; hospital admission; hospitalization; human; hydrothorax; loading drug dose; lobectomy; lung consolidation; lung infiltrate; lymphadenopathy; morbidity; mortality risk; nebulization; necrotizing pneumonia; physical examination; pleura effusion; pleura fluid; pleura thickening; pneumothorax; preschool child; resuscitation; thoracotomy; thorax radiography; wheezing |
Elsevier Inc. |
19300433 |
|
|
Article |
Q4 |
221 |
18127 |
|
|