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36 |
Djusad S., Meutia A.P., Tunggadewi S.A., Sari Y.M., Hakim S., Priyatini T., Moegni F., Santoso B.I. |
57192276788;57203368133;57377695800;57217020003;57192276095;57192265423;55450456100;56653822500; |
Genital self-image as predictor of sexual dysfunction in women with pelvic organ prolapse in Indonesia |
2021 |
Women's Health |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121423948&doi=10.1177%2f17455065211066019&partnerID=40&md5=607bdce156595c4225e7b7fef7a1b89c |
Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia |
Djusad, S., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Meutia, A.P., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Tunggadewi, S.A., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Sari, Y.M., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Hakim, S., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Priyatini, T., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Moegni, F., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Santoso, B.I., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia |
Background: The incidence of sexual dysfunction increases in women with pelvic organ prolapse. In addition to physical factors, other important components that influence each other in sexual dysfunction are psychological aspects and genital self-image. Sociocultural factors also affect individual sexuality and sexual behavior. Until now, there are no data and the relationship between genital self-image and sexual dysfunction in pelvic organ prolapse is not known in Indonesia. Objective: This study aims to analyze the correlation of genital self-image with sexual dysfunction in women with pelvic organ prolapse. Methods: In this cross-sectional study, 113 consecutive women with pelvic organ prolapse were selected in urogynecology referral centers in Jakarta. Demographic data, physical examination, and guided interviews were filled in to complete the Female Sexual Function Index and Female Genital Self-Image Scale-7 questionnaires. Preliminary research has been carried out in the form of language translation and cultural validation of the Indonesian version of the Female Genital Self-Image Scale-7 questionnaires. Results: There is a significant correlation between genital self-image and sexual dysfunction, where the lower Female Genital Self-Image Scale-7 score significantly predicts the lower Female Sexual Function Index score (p < 0.000; odds ratio: 14.17). Conclusion: Genital self-image is the main variable that affects sexual function in women with pelvic organ prolapse. It is necessary to evaluate and treat genital self-image because sexual function is an integrated component of quality of life. © The Author(s) 2021. |
eastern sexuality; Female Genital Self-Image Scale; female sexual dysfunction; Female Sexual Function Index; genital self-image; pelvic organ prolapse |
adult; Article; body mass; cancer staging; constipation; cross-sectional study; cystocele; depression; female; female sexual dysfunction; gynecologic surgery; human; major clinical study; marriage; pelvic examination; pelvic floor disorder; pelvic organ prolapse; psychometry; questionnaire; sexual behavior; sexual dysfunction; sexual function; sleep quality; urinary tract infection; vaginal delivery; genital system; Indonesia; pelvic organ prolapse; psychology; quality of life; Cross-Sectional Studies; Female; Genitalia; Humans; Indonesia; Pelvic Organ Prolapse; Quality of Life; Sexual Behavior; Surveys and Questionnaires |
SAGE Publications Ltd |
17455057 |
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34913375 |
Article |
Q1 |
1363 |
2670 |
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57 |
Diptyanusa A., Sari I.P. |
57205340891;57197543698; |
Treatment of human intestinal cryptosporidiosis: A review of published clinical trials |
2021 |
International Journal for Parasitology: Drugs and Drug Resistance |
17 |
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128 |
138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115755098&doi=10.1016%2fj.ijpddr.2021.09.001&partnerID=40&md5=e7d5494025a277d99586bf5f73027625 |
Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia; Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
Diptyanusa, A., Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia, Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis can result in long-term morbidity and high illness costs. The evidence of effective treatments for cryptosporidiosis has been lacking. We reviewed the published clinical trials to bring forward the feasible therapeutic options of human cryptosporidiosis in various populations and settings according to clinical improvement and parasite clearance rates. A total of 42 studies consisting of the use of nitazoxanide, paromomycin, macrolides, somatostatin analogues, letrazuril, albendazole, rifaximin, miltefosine, clofazimine, and colostrum were included in the review. The trials were mostly conducted in small number of individuals infected with human immunodeficiency virus (HIV), and there is inadequate data of controlled trials to suggest the use of these treatment modalities. Nitazoxanide was reported to be highly efficacious only in immunocompetent hosts and was found to be superior to paromomycin in the same group of patients. Macrolides showed no effective results in both clinical and parasitological improvement. Human bovine colostrum should possibly be administered as one of complementary therapeutic modalities along with other antimicrobials to reach optimal parasite eradication. Other trials of therapeutic modalities were terminated due to futility. Currently, available data is intended to aid the development of strategies for improving access to treatments in different clinical settings, as well as to help guide further studies on treatments of human intestinal cryptosporidiosis. © 2021 |
Clearance; Clinical trial; Cryptosporidiosis; Cryptosporidium; Drug; Treatment |
acetylspiramycin; albendazole; alkaline phosphatase; antiparasitic agent; azithromycin; clofazimine; erythromycin; garlicin; immunoglobulin; letrazuril; macrolide; miltefosine; nitazoxanide; octreotide; paromomycin; placebo; probiotic agent; rifaximin; roxithromycin; somatostatin derivative; spiramycin; unclassified drug; vapreotide; antiprotozoal agent; paromomycin; abdominal pain; adolescent; adult; aged; alkaline phosphatase level; alternative medicine; anorexia; antiparasitic therapy; child; cholecystitis; clinical trial (topic); colostrum; constipation; cryptosporidiosis; diarrhea; dizziness; drowsiness; drug efficacy; fatigue; fever; headache; health care access; human; Human immunodeficiency virus infection; hypertransaminasemia; infant; injection site pain; intestine obstruction; k |
Elsevier Ltd |
22113207 |
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34562754 |
Review |
Q1 |
1071 |
3953 |
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96 |
Irwinda R., Hiksas R., Lokeswara A.W., Wibowo N. |
57190855256;57226152029;57200937543;15049026900; |
Maternal and fetal characteristics to predict c-section delivery: A scoring system for pregnant women |
2021 |
Women's Health |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120494500&doi=10.1177%2f17455065211061969&partnerID=40&md5=24bd3b15eeeb46e6e6583c50495d671b |
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lokeswara, A.W., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Cesarean section is one of the most common obstetrical interventions that has been performed at an increasing rate globally, due to both medical and non-medical reasons. This study aims to develop a prediction tool for pregnant women potentially needing c-section, such that necessary preparations from the mothers, families, and health providers can be made. Methods: A total of 603 pregnant women were recruited in the first phase of c-section prediction tool development. The association between the maternal and fetal factors on the risk of c-section were analyzed, followed by a stepwise multivariate regression analysis. In the next phase, 61 pregnant women were enrolled for external validation. Discrimination was assessed using area under the curve. The calibration plot was then made and assessed using the Hosmer–Lemeshow test. Results: There were 251 (41.6%) cases of vaginal delivery and 352 (58.4%) of c-section assessed. Multivariate analysis showed that gestational age < 37 wg (OR: 1.66, 95% CI: 1.10–2.51), pre-pregnancy body mass index (underweight) (OR: 0.40, 95% CI: 0.22–0.76), no history of vaginal delivery (OR: 2.66, 95% CI: 1.76–4.02), history of uterine surgery (OR: 8.34, 95% CI: 4.54–15.30), obstetrical complications (OR: 5.61, 95% CI: 3.53–8.90), birthweight ⩾ 3500 g (OR: 4.28, 95% CI: 2.16–8.47), and non-cephalic presentation (OR: 2.74, 95% CI: 1.53–4.89) were independently associated with c-section delivery. Those parameters were included in a 7-item scoring tool, with consecutive predictive scores of 1,–1,2,3,3,2,2,1. The area under the curve result was 0.813 (95% CI: 0.779–0.847), indicating a good predictive ability. The external validation showed AUC: 0.806, 95% CI: 0.694–0.917, Hosmer–Lemeshow test p = 0.666 and calibration plot coefficient of r = 0.939. Conclusion: A total of 7 maternal-fetal factors were found to be strongly associated with c-section delivery, including gestational age < 37, maternal underweight body mass index, previous uterine surgery, obstetrical complications, birthweight ⩾ 3500, history of vaginal delivery, and non-cephalic presentation. Using these factors, a prediction tool was developed and validated with good quality. © The Author(s) 2021. |
cesarean section; maternal-fetal characteristics; mode of delivery; prediction; scoring system |
7 point scoring system; abdominal circumference; adult; area under the curve; Article; biological activity; birth weight; body mass; cesarean section; clinical examination; cohort analysis; diagnostic test accuracy study; exploratory factor analysis; female; fetus weight; forceps delivery; gestational age; human; major clinical study; maternal fetal characteristics; mortality; myomectomy; non cephalic presentation; obstetrical complication; prediction; pregnancy complication; pregnant woman; prenatal care; questionnaire; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; underweight; urologic surgery; vaginal delivery; obstetric delivery; pregnancy; Cesarean Section; Delivery, Obstetric; Female; Gestational Age; Humans; Pregnan |
SAGE Publications Ltd |
17455057 |
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34818932 |
Article |
Q1 |
1363 |
2670 |
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193 |
Putrantyo I.I., Mosahebi A., Smith O., de Vega B. |
57268843400;55985666400;54881691700;57222467939; |
Investigating Effectiveness of Topical Autologous Platelet-rich Plasma as Prophylaxis to Prevent Wound Infection: A Systematic Review and Meta-analysis |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
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72 |
82 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117073627&partnerID=40&md5=e2542cf5f0470226375c2d3b9af84e52 |
Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom; Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta Pusat, 10430, Indonesia; Cell and Tissue Bank-Regenerative Medicine Center, Dr Soetomo General Hospital, Surabaya, 60286, Indonesia |
Putrantyo, I.I., Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta Pusat, 10430, Indonesia; Mosahebi, A., Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom; Smith, O., Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom; de Vega, B., Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom, Cell and Tissue Bank-Regenerative Medicine Center, Dr Soetomo General Hospital, Surabaya, 60286, Indonesia |
Autologous platelet-rich plasma (PRP) was reported as having potent antimicrobial properties. However, the literature showed conflicting results. Therefore, we aim to investigate the effectiveness of topical autologous PRP as prophylaxis to prevent wound infection. We searched major electronic databases such as MEDLINE, EMBASE, CENTRAL, and Web of Science to identify RCT studies regarding this topic. The selection of included studies followed the PRISMA guidelines. We included ten RCTs comprising 1257 participants. In general, PRP showed no effect in reducing the risk of wound infection (RR: 0.84; 95% CI: 0.66–1.06; p=0.14). However, subgroup analysis based on wound characteristic showed that PRP significantly reduced wound infection risks in acute wounds (RR: 0.76; 95% CI: 0.58–0.99; p=0.04). Meanwhile, activation of PRP had no effect in reducing wound infection risks (p=0.77). In conclusion, we suggest routine autologous topical PRP application in acute wound care due to PRP antimicrobial properties and regenerative potential. © 2021 UPM Press. All rights reserved. |
Antimicrobial agent; Platelet-rich plasma; Systematic review; Topical administration; Wound infection |
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Universiti Putra Malaysia Press |
16758544 |
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Review |
Q4 |
144 |
23823 |
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297 |
Gozal F., Gondhowiardjo S.A., Kodrat H., Wibowo W.E. |
57272055100;6508327402;57210639849;57271503300; |
Dosimetric analysis of three-dimensional conformal radiotherapy, intensity-modulated radiotherapy-step and shoot, helical tomotherapy, and volumetric modulated arc therapy in prostate cancer radiotherapy |
2021 |
Journal of Cancer Research and Therapeutics |
17 |
4 |
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893 |
900 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115716207&doi=10.4103%2fjcrt.JCRT_57_19&partnerID=40&md5=dd9c0144cb3b9a97d6b48eed122e1ba2 |
Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Gozal, F., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Gondhowiardjo, S.A., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wibowo, W.E., Radiation Oncology Department, Rumah Sakit Cipto Mangunkusumo, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: There is limited study comparing dosimetry parameters in detail. In regard to prostate cancer, there are four different techniques, namely three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy-step and shoot (IMRT-SS), IMRT-helical tomotherapy (HT), and volumetric-modulated arc therapy (VMAT). Materials and Methods: Experimental study with intervention on ten prostate cancer patients’ computed tomography planning data. 78 Gy dose in 39 fractions was given for planning target volume. Results: The mean V75 Gy rectum and bladder between 3D-CRT and the other three abovementioned techniques all showed significant results (P < 0.05). V5 Gy remaining volume at risk (RVR) between 3D-CRT versus VMAT and HT, IMRT-SS versus HT, and VMAT versus HT is statistically significant (P < 0.0001). The longest radiation time was done with HT (mean 4.70 ± 0.84 min). Conclusion: V75 Gy rectum bladder between 3D-CRT techniques differ significantly compared to the three other techniques and may not be suitable to the implementation of escalation doses. The HT technique produced the highest V5 Gy RVR and needed the highest monitor unit amount and the longest radiation duration. The VMAT technique was considered capable of realizing dose escalation in prostate cancer radiotherapy by minimizing toxicity in the rectum and bladder with the shortest radiation duration. © 2020 Journal of Cancer Research and Therapeutics. |
Helical tomotherapy; Intensity-modulated radiotherapy-step and shoot; Prostate cancer; Three-dimensional conformal radiotherapy; Volumetric-modulated arc therapy |
adult; aged; anisotropic analytical algorithm; Article; bladder; bladder capacity; cancer radiotherapy; clinical article; clinical target volume; computer assisted tomography; conformal radiotherapy; controlled study; dosimetry; health care; human; intensity modulated radiation therapy; male; middle aged; planning; planning target volume; prostate cancer; radiotherapy dosage; rectum; tomotherapy; volumetric modulated arc therapy; conformal radiotherapy; diagnostic imaging; follow up; intensity modulated radiation therapy; organs at risk; pathology; procedures; prognosis; prostate tumor; radiation response; radiotherapy planning system; spiral computer assisted tomography; Aged; Follow-Up Studies; Humans; Male; Middle Aged; Organs at Risk; Prognosis; Prostatic Neoplasms; Radiotherapy Dosage |
Wolters Kluwer Medknow Publications |
09731482 |
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34528538 |
Article |
Q3 |
475 |
10526 |
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464 |
Cahyono A.T., Louisa M., Mayang Permata T.B., Handoko, Nuryadi E., Kodrat H., Wibowo H., Hariandy Hamid A.R.A., Sekarutami S.M., Gondhowiardjo S.A. |
57222900545;41461551400;57197808751;57209984822;57197806814;57210639849;57217690943;57202054669;56576294500;6508327402; |
The potential of gallic acid as a radiosensitizer on human prostate cancer: A systematic review of preclinical studies |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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246 |
254 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104201486&partnerID=40&md5=aff7e4b57216dc4b88ee83f02823372e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Cahyono, A.T., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, H., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hariandy Hamid, A.R.A., Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Prostate adenocarcinoma accounts for majority of prostate cancer cases, and it was found to be highly radioresistant. Gallic acid is a phenolic acid naturally occurring in many plants, reported to exhibit biological activities in eliminating cancer cell lines and xenografts. The purpose of this study is to review gallic acid as a potential radiosensitizer agent in prostate cancer treatment. Article search was conducted in PubMed, EBSCO, and Scopus. 11 studies using different cell lines including DU145, PC-3, LNCaP, and 22Rv1 xenograft of human prostate cancer were reviewed in this paper. Gallic acid acts as a radiosensitizer mainly by increasing caspase-3 and caspase-9 activation resulting in apoptosis, while also reducing intracellular CDKs, cyclins, and cdc25 phosphatases ultimately causing G2-M cell cycle arrest. Gallic acid has a potential to be a new radiosensitizer compound in prostate cancer treatment. Additional clinical studies using gallic acid derivatives with lower hydrophilicity are needed. © 2021 UPM Press. All rights reserved. |
Apoptosis; Gallic acid; Prostate cancer; Radiobiology; Radiotherapy |
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Universiti Putra Malaysia Press |
16758544 |
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Review |
Q4 |
144 |
23823 |
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465 |
Mochtar I., Adi N.P., Hardjono A.W., Mansyur M. |
57222902121;57023786200;57222902350;37085506800; |
Return to work assessment in a radiographer assistant suffering a hemianopsia due to an ischemic stroke |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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301 |
304 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104187321&partnerID=40&md5=cad74495ef91661c388194494f7d4e58 |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia |
Mochtar, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Adi, N.P., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Hardjono, A.W., Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Return to work assessment (RTWA) has been performed to a radiographer assistant suffering a hemianopsia due to an ischemic stroke. Stroke occurred two months prior to the examination. The general condition of the patient was good. The systemic examination was unremarkable except the presence of a partial vision loss in the left eye and often feeling fatigue and down. Perimetry Full-field 120 Point Screening Test confirmed a left temporal hemianopsia while Patient Health Questionnaire’s score (PHQ-9) indicated a moderate depression. The two conditions were not fully compatible with the job demand of a radiographer assistant, which required a complete and clear visual field as well as a good mental status. Risk assessment indicated that the patient might encounter health and safety issues if he resumed duty without work adjustment. The clinic still wanted to employ the patient and agreed to provide support. The patient was declared ‘fit’ to resume his duty with some recommendations. © 2021 UPM Press. All rights reserved. |
Hemianopsia; Return to work; Stroke |
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Universiti Putra Malaysia Press |
16758544 |
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Article |
Q4 |
144 |
23823 |
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853 |
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 |
2021 |
Autophagy |
17 |
1 |
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1 |
382 |
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312 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102619204&doi=10.1080%2f15548627.2020.1797280&partnerID=40&md5=32bc24d3ffd8e3f626d0d619cf3a8fc8 |
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In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
Autophagosome; cancer; flux; LC3; lysosome; macroautophagy; neurodegeneration; phagophore; stress; vacuole |
adenylate kinase; atg16l1 protein; autophagy related protein; autophagy related protein 14; autophagy related protein 18; autophagy related protein 5; autophagy related protein 8 family; beclin 1; biological marker; dfcp1 protein; DNA; gamma interferon; green fluorescent protein; mammalian target of rapamycin; nanoparticle; phosphatidylinositol 3 kinase; protein; RNA; sequestosome 1; serine threonine protein kinase ULK1; SNARE protein; sphingolipid; stx17 protein; tecpr1 protein; ubiquitin; unclassified drug; aggrephagy; apicoplast; assay; autophagosome; autophagy (cellular); bimolecular fluorescence complementation; Caenorhabditis elegans; cell death; cell nucleus; cell stress; cell vacuole; chlorophagy; chromatophagy; clockophagy; crinophagy; data base; doryphagy; Drosophila melanogaster |
Taylor and Francis Ltd. |
15548627 |
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33634751 |
Review |
Q1 |
3934 |
400 |
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