No records
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861 |
Umas R.A., Supriadi S., Whulanza Y., Hasan A.A.A.F., Kreshanti P. |
57222252781;16040272500;36807053500;57222257599;36192866200; |
Evaluating the Gear Stress of Novel Reverse Rotation Bit Manual Screwdriver Design for Miniscrew Implants |
2021 |
Journal of Mechanical Engineering |
18 |
1 |
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175 |
192 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102086175&partnerID=40&md5=0196752c2bad6ab9b05bb97c07712c5b |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Cleft and Craniofacial Center Cipto Mangunkusumo Hospital, Plastic and Reconstructive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
Umas, R.A., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Hasan, A.A.A.F., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia; Kreshanti, P., Cleft and Craniofacial Center Cipto Mangunkusumo Hospital, Plastic and Reconstructive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
One of the problems faced by the screwdrivers used for craniomaxillofacial implant fixation is that the maximum torque required for implant removal is significantly higher than the maximum torque needed for inserting implants. Another problem is that the hand torque produced by a right-handed person is lower in the counterclockwise direction, which is the removal direction for miniscrews. The novel design presented here of a manual screwdriver equipped with an epicyclic gear will produce a reverse bit rotation and provide the mechanical advantage of higher torque output. In this study, simulations were conducted by varying the torque input within the range of 0-1000 Nmm with an applied load in each simulation to be adapted based on the epicyclic gear set. The materials used in this study are AISI 316L and Ti6Al4V. The maximum Von Mises stress value was observed in the sun gear from the second gear set at 522.59 MPa (AISI 316L) and 430.76 MPa (Ti6Al4V) for the maximum torque input, which was followed by the planetary and ring gear from the second gear set and then the planetary gear, ring gear, and sun gear from the first gear set. The total deformation also showed the difference between the two materials; the deformation when using AISI 316L as the material was lower than when using Ti6Al4V. © 2021 Faculty of Mechanical Engineering. All Rights Reserved. |
Epicyclic Gear; Maxillofacial Implant; Surgical Screwdriver |
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UiTM Press |
18235514 |
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Article |
Q3 |
216 |
18402 |
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No records
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285 |
MANSYUR A.S., WIDYAHENING I.S., SUDARSONO N.C. |
57312107800;54893154400;57201862518; |
Incidence of musculoskeletal injuries among Indonesian volleyball athletes during a national training and championship |
2021 |
Gazzetta Medica Italiana Archivio per le Scienze Mediche |
180 |
7-8 |
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374 |
379 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117904317&doi=10.23736%2fS0393-3660.20.04382-X&partnerID=40&md5=706fa0522bf3dbc8cae2b23a407d416b |
Sports Medicine Study Program, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Family Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Sports Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
MANSYUR, A.S., Sports Medicine Study Program, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; WIDYAHENING, I.S., Division of Family Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; SUDARSONO, N.C., Division of Sports Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: This study aimed to find out the incidence and characteristics of musculoskeletal injuries among Indonesian volleyball athletes during a national volleyball training and championship. METHODS: A prospective cohort study involving 34 Indonesian volleyball national team athletes (18 male and 16 female) during one volleyball national training and championship in July-September 2019 was conducted. All athletes were observed for 11 weeks and the incidence and the characteristics (duration, pain level, severity in loss time, nature, recurrence, anatomical location and types) of the injuries were documented. Some etiological factors of the injuries such as the court zone (back, front/net, and un-specified) time of injury (practice, competition or both), injury mechanism (ball contact, player contact, surface contact, non-contact or overuse), biomechanics (bending, compression, repetitive or traction) and movements (blocking, digging, passing, serving, spiking, or not specific) were also recorded. Incidence of injuries was presented in 1000 player hours. RESULTS: The incidence of injuries was 20.4/1000 player hours. Only one out of the 34 athletes did not have injury. Injuries occurred most frequently in the knee (36%), followed by the ankle (18%) and waist (16%). The most common type of injuries was sprain (21%) and tendinitis (21%) followed by low back pain (13%). The overuse and recurrence type of injuries were much more dominant to the acute one. CONCLUSIONS: Musculoskeletal injuries were common among Indonesian volleyball athletes. This adds information to the limited available evidence concerning the incidence, prevalence and etiology of volleyball-specific injuries which were needed to prevent its occurrence. © 2021 Edizioni Minerva Medica. All rights reserved. |
Athletes; Cumulative trauma disorders; Sports medicine; Volleyball |
adult; ankle; Article; athlete; beep test; biomechanics; body mass; bursitis; cardiopulmonary endurance; clinical article; cohort analysis; compression; concussion; court; elbow; female; hand-grip strength test; head; human; incidence; Indonesian; knee; low back pain; male; maximal oxygen uptake; muscle exercise; muscle strength; musculoskeletal injury; nuclear magnetic resonance imaging; patellofemoral pain syndrome; physical examination; prospective study; shoulder; shuttle run test; situp test; sprain; tendinitis; training; volleyball; x-ray computed tomography |
Edizioni Minerva Medica |
03933660 |
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Article |
Q4 |
114 |
27889 |
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No records
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518 |
Apriadi W., Gani H.S., Prayitno P., Ibrahim N., Wijaya S.K. |
57205292872;57202775842;57222538092;56609777400;6506884322; |
Development of multithread acquisition system for high quality EEG signal measurement |
2021 |
Journal of Physics: Conference Series |
1816 |
1 |
012072 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103129496&doi=10.1088%2f1742-6596%2f1816%2f1%2f012072&partnerID=40&md5=8df825ddfea9b100797241af3b95358e |
Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Department of Physiology, Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia |
Apriadi, W., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Gani, H.S., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Prayitno, P., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Ibrahim, N., Department of Physiology, Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia; Wijaya, S.K., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia |
This work was concerned on development of the EEG acquisition and EEG signal processing by adding active electrodes and implementing multithread techniques. By using active electrodes, mounting them on the scalp surface would be easier to capture low signals of less than 1µV. The active electrodes were used to reduce noise when transfer signals from the electrode to the acquisition systems which equipped 20 gain. The verification was performed by comparing the active and passive electrodes using NETECH MiniSIM EEG Simulator 330. The advantage of this research was to reduce time delay for EEG signal computation on 32 channels. The acquisition system was based on Raspberry Pi and ADS1299 with multithread signal treatment. Signal filtering was performed into different threads and put all the EEG features into the database. A PC was used to process signal calculation such as processing FFT, signal feature extractions, and signal analysis. These calculations were divided into several functionally independent computations. The signals of each channel were calculated into different threads. The results of this work showed the effectiveness of the multithreaded method for processing large amounts of data (32 channels of 24 bits EEG signal) with low noise levels on the active electrodes. © Published under licence by IOP Publishing Ltd. |
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Electrodes; Acquisition systems; Active electrodes; Eeg acquisitions; EEG signal processing; Large amounts of data; Multithread techniques; Signal treatments; Transfer signals; Biomedical signal processing |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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No records
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492 |
Maulidina F., Rustam Z., Hartini S., Wibowo V.V.P., Wirasati I., Sadewo W. |
57221906584;26422482100;57211529061;57221911837;57221806240;55014544900; |
Feature optimization using Backward Elimination and Support Vector Machines (SVM) algorithm for diabetes classification |
2021 |
Journal of Physics: Conference Series |
1821 |
1 |
012006 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103897338&doi=10.1088%2f1742-6596%2f1821%2f1%2f012006&partnerID=40&md5=26c4c2f598bd765549c0283978c63185 |
Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Maulidina, F., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Rustam, Z., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Hartini, S., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Wibowo, V.V.P., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Wirasati, I., Departement of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Sadewo, W., Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Diabetes is a disease that occurs when the blood glucose level is higher than normal and also leads to health problems. Early and accurate diagnosis needs to be carried out on individuals affected by this disease. Furthermore, excellent treatment needs to be provided to prevent worse situations. Some studies have used several machine learning methods to diagnose diabetes. Furthermore, in this study, the Backward Elimination and Support Vector Machine (SVM) algorithm was used to classify the PIMA Indians diabetes dataset. It consisted of 268 diabetic and 500 non-diabetic patients with eight attributes. Backward Elimination is a feature selection method used to remove irrelevant features based on the linear regression model. Using this method, the right features for the model was expected. This method has some advantages which include increasing training time, decreasing complexity and improving performance and accuracy. Therefore, the performance of SVM improved. Based on the experiments, it was discovered that by combining feature selection algorithm (backward elimination) and SVM, the highest accuracy obtained was 85.71% using 90% data training. Therefore, it was concluded that Backward Elimination combined with SVM algorithm is an excellent method to classify diabetes by using the PIMA Indians diabetes dataset. © Published under licence by IOP Publishing Ltd. |
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Classification (of information); Diagnosis; Experimental mineralogy; Feature extraction; Learning systems; Regression analysis; Feature optimizations; Feature selection algorithm; Feature selection methods; Improving performance; Linear regression models; Machine learning methods; Support vector machine algorithm; Support vector machines algorithms; Support vector machines |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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493 |
Wibowo V.V.P., Rustam Z., Hartini S., Maulidina F., Wirasati I., Sadewo W. |
57221911837;26422482100;57211529061;57221906584;57221806240;55014544900; |
Ovarian cancer classification using K-Nearest Neighbor and Support Vector Machine |
2021 |
Journal of Physics: Conference Series |
1821 |
1 |
012007 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103891589&doi=10.1088%2f1742-6596%2f1821%2f1%2f012007&partnerID=40&md5=8b428e7f3e510029f71b6c464cefbd2d |
Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Wibowo, V.V.P., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Rustam, Z., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Hartini, S., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Maulidina, F., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Wirasati, I., Department of Mathematics, University of Indonesia, Depok, 16424, Indonesia; Sadewo, W., Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Ovarian cancer is one of the common malignancies in women and a known cause of death. This condition occurs when a tumor appears from the growth of abnormal cells in the ovary. It causes about 140.000 deaths out of 225.000 cases annually. Most women with ovarian cancer do not have distinctive signs and symptoms even at the late stage. Therefore, diagnosis at an early stage is necessary because it has a significant impact on the survival rate. Machine learning with various methods can be used in the medical field to classify diseases. Among the many methods, K-Nearest Neighbor (KNN) and Support Vector Machine (SVM) were used and analyzed in this study to classify ovarian cancer. The data used were from Al Islam Bandung Hospital consisting of 203 instances with 130 labeled ovarian cancer and 73 as non-ovarian. The results showed that the KNN produced higher results than SVM with 90.47% of accuracy and 94.11% of F1-score, while SVM produced accuracy and F1-score values of 90.47% and 92.30% respectively. © Published under licence by IOP Publishing Ltd. |
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Diagnosis; Diseases; Motion compensation; Nearest neighbor search; F1 scores; K nearest neighbor (KNN); K-nearest neighbors; Late stage; Medical fields; Ovarian cancers; Survival rate; Support vector machines |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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No records
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420 |
Sunarno, Khariri, Muna F., Sariadji K., Rukminiati Y., Febriyana D., Febrianti T., Saraswati R.D., Susanti I., Puspandari N., Karuniawati A., Malik A., Soebandrio A. |
57222956230;57222528104;57218911032;57199654249;57214868942;57222530233;57222528085;57214871905;57222520009;56786591900;54886816200;35079198800;8602893200; |
New approach for the identification of potentially toxigenic Corynebacterium sp. using a multiplex PCR assay |
2021 |
Journal of Microbiological Methods |
184 |
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106198 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103000221&doi=10.1016%2fj.mimet.2021.106198&partnerID=40&md5=3183ff3090d2d560fdf7771ab93c7a66 |
Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Microbiology and Biotechnology Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Sunarno, Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Khariri, Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Muna, F., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Sariadji, K., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Rukminiati, Y., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Febriyana, D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Febrianti, T., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Saraswati, R.D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Susanti, I., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Karuniawati, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Malik, A., Division of Microbiology and Biotechnology Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Soebandrio, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
In diphtheria laboratory examinations, the PCR test can be applied to isolates and clinical specimens. This study aimed to develop a PCR assay to identify the species and toxigenicity of diphtheria-causing bacteria, including the prediction of some NTTB types. Seven reference isolates, four synthetic DNA samples, 36 stored isolates, and 487 clinical samples used for PCR optimization. The PCR results was confirmed by DNA sequence analysis. The results of the PCR examination of the 7 reference isolates and 36 stored isolates were similar to the results obtained using conventional methods as gold standard, both for diphtheria-causing and non-diphtheria-causing bacteria. The validation of the PCR results using DNA sequence analysis showed that there was no mispriming or misamplification. The multiplex PCR assay developed in this study could correctly identify the species and toxigenicity of diphtheria-causing bacteria, including the prediction of some NTTB types not yet covered by established PCR methods. © 2021 Elsevier B.V. |
Diphtheria; dtxR gene; PCR; Potentially toxigenic Corynebacterium |
Article; bacterial gene; bacterium identification; controlled study; Corynebacterium; diphtheria; DNA sequence; dtxR gene; gold standard; multiplex polymerase chain reaction; nonhuman; priority journal; bacterium identification; classification; Corynebacterium; Corynebacterium infection; genetics; human; isolation and purification; microbiology; multiplex polymerase chain reaction; procedures; bacterial protein; primer DNA; Bacterial Proteins; Bacterial Typing Techniques; Corynebacterium; Corynebacterium Infections; Diphtheria; DNA Primers; Humans; Multiplex Polymerase Chain Reaction |
Elsevier B.V. |
01677012 |
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33713727 |
Article |
Q3 |
629 |
8028 |
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No records
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13 |
Sumapraja K., Hestiantoro A., Liem I.K., Boediono A., Jacoeb T.Z. |
55819683500;8743255100;55802927800;9040094200;57192887569; |
Effect of conditioned medium of umbilical cord-derived mesenchymal stem cells as a culture medium for human granulosa cells: An experimental study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
12 |
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1037 |
1044 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124898321&doi=10.18502%2fijrm.v19i12.10054&partnerID=40&md5=aa14230b44e7cc7c0f12adca3c46c2b5 |
Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Sumapraja, K., Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hestiantoro, A., Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Boediono, A., Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jacoeb, T.Z., Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Background: The umbilical cord-derived mesenchymal stem cells conditioned medium (UC-MSCs-CM) produces secretomes with anti-apoptotic properties, and has the potential to prevent apoptosis of granulosa cells (GC) during controlled ovarian hyperstimulation. Objective: To observe the effect of UC-MSCs-CM on the interaction between pro-and anti-apoptotic proteins and the influence of growth differentiation factor 9 (GDF9) production in GC. Materials and Methods: UC-MSCs-CM was collected from umbilical cord stem cell culture on passage 4. GC from 23 women who underwent in vitro fertilization were cultured and exposed to UC-MSCs-CM for 24 hr. Then RNA of the GC was extracted and the mRNA expression of BCL-2 associated X (BAX), survivin and GDF9 were analysed using quantitative real-time PCR. The spent culture media of the GC were collected for measurement of insulin growth factor 1 using ELISA. Results: The expression of BAX was significantly different after UC-MSCs-CM exposure (4.09E-7 vs. 3.74E-7, p = 0.02). No significant changes occurred in survivin, BAX/survivin ratio, and GDF9 expression after UC-MSCs-CM exposure (p > 0.05). The IGF-1 level of the CM was significantly higher after the CM was used as a culture medium for GC (2.28 vs. 3.07 ± 1.72, p ≤ 0.001). A significant positive correlation was found between survivin and GDF9 (r = 0.966, p ≤ 0.001). Conclusion: IGF-1 produced by UC-MSCs-CM can work in paracrine fashion through the IGF receptor, which can inhibit BAX and maintain GDF9 production. Moreover, under the influence of UC-MSCs-CM, GC are also capable of producing IGF-1, which can impact GC through autocrine processes. © Sumapraja et al. |
BAX; Conditioned medium; GDF9; IGF-1; Survivin |
anti apoptotic protein; baculoviral IAP repeat containing protein 5; complementary DNA; growth differentiation factor 9; Muellerian inhibiting factor; pro apoptotic protein; protein; protein Bax; protein bcl 2; recombinant follitropin; somatomedin; unclassified drug; adult; anesthesia; antiapoptotic activity; antral follicle count; Article; autocrine signaling; cell culture; clinical article; DNA synthesis; enzyme linked immunosorbent assay; female; granulosa cell; human; human cell; in vitro fertilization; information processing; mRNA expression level; oocyte; ovary follicle fluid; real time polymerase chain reaction; RNA extraction; umbilical cord mesenchymal stem cell |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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61 |
Sukrisman L. |
8661764000; |
Soluble P-selectin and correlation with Prothrombin Fragment 1 + 2 in myeloid malignancies in Cipto Mangunkusumo general hospital |
2021 |
Thrombosis Journal |
19 |
1 |
51 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111667161&doi=10.1186%2fs12959-021-00307-5&partnerID=40&md5=29949e22d24b9e6bcdb419fb321d6664 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Sukrisman, L., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Myeloid cells express microparticles that could increase the expression of adhesion molecules including P-selectin. We aimed to evaluate the level of soluble P-selectin (sP-selectin) and prothrombin fragment 1 + 2 (F1 + 2), and to determine correlation of sP-selectin with leukocyte count and F1 + 2 levels in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients. Methods: Patients with newly diagnosed AML (n = 25), CML (n = 13), and controls (n = 17) were recruited in this study. The diagnosis of AML and CML is based on 2001 WHO and/or FAB criteria. Levels of sP-selectin and F1 + 2 were determined using enzyme-linked immunosorbent assay kits (Behring ELISA Processor-III® and Behring Enzygnost F1 + 2). Results: sP-selectin was significantly elevated in CML patients compared to AML patients (p = 0.001). Levels of F1 + 2 in AML and CML patients were significantly increased in comparison to controls (p < 0.001 and p = 0.043). Levels of sP-selectin were significantly correlated to leukocyte count (r = 0.437; p = 0.029) and F1 + 2 (r = 0.436; p = 0.029) in AML patients. Conclusions: AML and CML patients had an increased tendency to thrombosis. While CML patients had higher platelet and/or endothelial activation, hypercoagulable state are more pronounced in AML patients. © 2021, The Author(s). |
AML; CML; F1 + 2; sP-selectin |
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BioMed Central Ltd |
14779560 |
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Article |
Q2 |
1004 |
4364 |
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68 |
Yunihastuti E., Amelia F., Hapsari A.I., Wicaksana B., Natali V., Widhani A., Sulaiman A.S., Karjadi T.H. |
57221273925;57216937074;57224070662;57216937319;57216936185;57202561455;57216938482;57219422563; |
Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus |
2021 |
Health and Quality of Life Outcomes |
19 |
1 |
154 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106964144&doi=10.1186%2fs12955-021-01777-x&partnerID=40&md5=2f9401a263635d553b2c13c95a895839 |
Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia; HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hepatobilliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yunihastuti, E., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Amelia, F., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hapsari, A.I., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Wicaksana, B., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Natali, V., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Widhani, A., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Sulaiman, A.S., Hepatobilliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karjadi, T.H., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia |
Background: We conducted a real-life study of health-related quality of life (HRQoL) transformation before and 12 weeks after sofosbuvir and daclatasvir therapy in HCV/HIV co-infected patients. Factors related to the significant changes of each HRQoL domain/item were also evaluated. Methods: A prospective study was performed in the HIV integrated clinic at Cipto Mangunkusumo Hospital, Jakarta. HCV/HIV co-infected patients who started sofosbuvir and daclatasvir from government free DAA program in 2017–2019. WHOQoL-HIV BREF and RAND SF-36 questionnaires were recorded at baseline and post-treatment week 12. Results: 145 patients with mean age of 37.8 years (SD = 4.2) were included in the analysis. Most of patients were male (89%), previous IVDU (89%), active smoker (50.4%) and non-cirrhosis (80%). SVR12 was achieved in 95.5% of patients. Sofosbuvir and daclatasvir treatments showed positive impacts on 2 domains and 2 other items of WHOQoL-HIV BREF and 2 domains and 1 item of SF-36. Predicting factors of significant increase in each domain/item were: male and normal body mass index (BMI) for level of independence (RR 4.01,95% CI 1.09–14.74 and 4.80,95% CI 1.79–12.81); higher HCV-RNA for overall perception of QoL (RR 0.42,95% CI 0.18–0.94); non-smoking status for overall perception of health (RR 0.32,95% CI 0.15–0.66); male and fibrosis stage 0–1 for general health (RR 6.21,95% CI 1.69–22.88 and 2.86,95% CI 1.16–7.00); and the use of NNRTI-based ART (RR 5.23, 95% CI 1.16–23.65). Spiritual/personal belief decline was predicted by non-smoking status (RR 0.46, 95% CI 0.23–0.95). Treatment success was not associated with any changes of HR-QoL domain/item. Conclusions: HCV/HIV co-infected patients were successfully treated with sofosbuvir and daclatasvir and experienced improvement of HRQoL 12 weeks after treatment completion. © 2021, The Author(s). |
Daclastavir; HCV; Health-related quality of life; Hepatitis C; HIV; Sofosbuvir |
daclatasvir; efavirenz; nevirapine; nonnucleoside reverse transcriptase inhibitor; sofosbuvir; antivirus agent; carbamic acid derivative; imidazole derivative; pyrrolidine derivative; sofosbuvir; valine; adult; age; antiretroviral therapy; Article; attitude to health; body mass; cohort analysis; coinfection; controlled study; current smoker; drug effect; drug use; female; general condition improvement; government regulation; health program; hepatitis C; Hepatitis C virus; human; Human immunodeficiency virus; Human immunodeficiency virus infection; liver cirrhosis; major clinical study; male; non-smoker; observational study; patient care; prediction; prospective study; quality of life; Short Form 36; sustained virologic response; treatment duration; treatment outcome; chronic hepatitis C; c |
BioMed Central Ltd |
14777525 |
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34039353 |
Article |
Q1 |
1084 |
3877 |
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300 |
Muharam R., Rizal M.S. |
57191492732;57226812403; |
Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
7 |
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637 |
644 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112743809&doi=10.18502%2fijrm.v19i7.9474&partnerID=40&md5=34cae0bd86e4721b17270090a5a30ef4 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Muharam, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Rizal, M.S., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: Endometriosis is closely associated with delayed diagnosis due to the lack of a definitive and sensitive noninvasive approach. The use of calprotectin in inflammatory process has been demonstrated in various inflammatory diseases. Calprotectin has a significant correlation with high-sensitivity C-reactive protein (hs-CRP) and could be used as an inflammatory marker. No study thus far has evaluated the correlation between calprotectin and endometriosis. Objective: To determine the correlation of calprotectin with the degree of endometriosis in order to help clinicians in establishing better early detection and management. Materials and Methods: In this cross-sectional study, 46 women referred to the Cipto Mangunkusumo, Fatmawati, and Persahabatan Hospitals in Jakarta, Indonesia between July 2017 and April 2018 were enrolled, and their blood serum were taken a day before surgery. Calprotectin serum level was treated using the Phical® ELISA method. After the diagnosis of endometriosis was confirmed through pathological examination, the final diagnosis of endometriosis could be established. The degree of endometriosis was classified according to the revised American Society for Reproductive Medicine (ASRM) classification. Results: The prevalence of minimal, mild, moderate, and severe degrees of endometriosis were 15.2, 39.1, 34.8, and 10.9%, respectively. The median serum calprotectin levels for minimal, mild, moderate, and severe endometriosis were 138.98, 121.49, 124.16, and 122.82 mg/mL, respectively. No correlation was observed between calprotectin and the degrees of endometriosis (r = –0.16, p = 0.278). Conclusion: There is no correlation between calprotectin serum levels and the degrees of endometriosis. © Muharam et al. |
C-reactive protein; Calprotectin; Endometriosis; Inflammation |
biological marker; C reactive protein; calgranulin; adolescent; adult; Article; body mass; correlation coefficient; cross-sectional study; diabetes mellitus; diastolic blood pressure; early diagnosis; endometriosis; enzyme linked immunosorbent assay; female; female infertility; glucose blood level; human; hypertension; major clinical study; protein expression |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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