No records
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431 |
Marzuki N.S., Idris F.P., Kartapradja H., Renata S., Harahap A., Latief Batubara J.R. |
37111053300;57224096699;6504373157;57224098534;6507325543;57224097014; |
Accuracy of urinary etiocholanolone/androsterone ratio as alternative to serum testosterone/dihydrotestosterone ratio for diagnosis of 5 alpha-reductase type 2 deficiency patients and carriers in Indonesia |
2021 |
International Journal of Endocrinology and Metabolism |
19 |
2 |
e109510 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106858176&doi=10.5812%2fIJEM.109510&partnerID=40&md5=262ad88d94d397f7bc55e0ace31050be |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Marzuki, N.S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Idris, F.P., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Kartapradja, H., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Renata, S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Harahap, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Latief Batubara, J.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The 5 Alpha-reductase type 2 deficiency (5ARD2) is an inherited condition, which clinically presents as variable degrees of under virilization in affected 46,XY individuals. In the diagnostic pathway of 5ARD2, the testosterone/dihydrotestosterone (T/DHT) ratio is broadly employed before molecular analysis of the SRD5A2 gene. However, due to cost-benefit considerations, the DHT test in our country is routinely lacking in clinical settings; therefore, we considered applying the urinary etiocholanolone/androsterone (Et/An) ratio as an alternative test. Objectives: We aimed to determine the diagnostic value of the urinary Et/An ratio versus the T/DHT ratio in diagnosing 5ARD2 patients and carriers. Methods: Sixty-six suspected 5ARD2 46,XY disorders of sex development (DSD) individuals and 95 family members were recruited in the study. Their clinical manifestations, T/DHT and urinary Et/An ratios, and SRD5A2 genes were analyzed. Using molecular analysis of the SRD5A2 gene as the gold standard, we compared the accuracy of both ratios in diagnosing 5ARD2 patients and carriers with receiver operating characteristic (ROC) curve analysis. Results: Thirty-seven patients were confirmed molecularly to have 5ARD2, and the rest (n = 29) were assessed as normal controls, while in the carrier group, 53 were molecularly confirmed as carriers and 42 as controls. The AUCs (areas under the curve) of the T/DHT and urinary Et/An ratios were 57.7% (95% CI 43.0 - 72.4%, P > 0.05) and 79.7% (95% CI 69.0 - 90.4%, P < 0.001), respectively, in diagnosing 5ARD2 patients and 54.1% (95% CI 42.4 - 65.8%, P > 0.05) and 75.1% (95% CI 65.1 - 85.1%, P < 0.001), respectively, in diagnosing carriers. The cutoff value of the urinary Et/An ratio was set at ≥ 0.95 for detecting 5ARD2 patients and ≥ 0.99 for detecting carriers. Conclusions: The testosterone/DHT ratio was inaccurate in diagnosing 5ARD2 patients. When molecular analysis for the SRD5A2 gene is lacking, the urinary Et/An ratio may be a useful test to diagnose 5ARD2 patients and carriers. Copyright © 2021, International Journal of Endocrinology and Metabolism. |
46; 5 Alpha-reductase 2 deficiency; Androsterone; Dihydrotestosterone; Etiocholanolone; SRD5A2; Testosterone; XY DSD |
androstanolone; androsterone; chorionic gonadotropin; etiocholanolone; genomic DNA; steroid; steroid 5alpha reductase 2; testosterone; 5 alpha reductase deficiency; adolescent; adult; analytical parameters; area under the curve; Article; child; clinical article; clinical assessment; clinical feature; competitive ELISA; controlled study; cost benefit analysis; diagnostic accuracy; diagnostic value; disorder of sex development; female; genetic analysis; hormone urine level; human; human tissue; Indonesia; infant; male; molecular biology; neutrophil lymphocyte ratio; newborn; receiver operating characteristic; serum testosterone dihydrotestosterone ratio; testosterone blood level; urinary etiocholanolone androsterone ratio |
Kowsar Medical Institute |
1726913X |
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Article |
Q3 |
652 |
7699 |
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549 |
Matondang S., Suwita B.M., Budianto T., Krisnuhoni E. |
57192085914;57192314180;57195936458;35310982200; |
Atypical CT and MR imaging of insulinoma: A case report |
2021 |
Journal of Clinical and Translational Endocrinology: Case Reports |
19 |
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100075 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097766381&doi=10.1016%2fj.jecr.2020.100075&partnerID=40&md5=30b9ef688ea8900819c2dfbaffb5061d |
Department of Radiology, Faculty of Medicine Universitas Indonesia-dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Matondang, S., Department of Radiology, Faculty of Medicine Universitas Indonesia-dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suwita, B.M., Department of Radiology, Faculty of Medicine Universitas Indonesia-dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Budianto, T., Department of Radiology, Faculty of Medicine Universitas Indonesia-dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Insulinoma is a rare endocrine tumor that causes hypoglycemia, with incidence of only 1–4 cases per 1 million population. Various clinical manifestations of hypoglycemia may resemble neurological, psychiatric and cardiac problems, which result in diagnosis delay. In this case, we reported a 30-year-old woman experiencing deterioration of consciousness and history of repeated seizures, despite normal EEG, brain CT and MRI. Multiphase contrast-enhanced abdominal CT showed hypovascular nodule, which is not typical for insulinoma. Multiphase contrast-enhanced MRI showed hypointense T1WI, hyperintense T2WI pancreatic nodule which enhance in arterial phase. Laboratory and histopathological examination confirm the diagnosis of neuroendocrine tumor. We described the atypical clinical manifestations, as well as atypical imaging appearance of pancreatic insulinoma in this patient. Lesion characteristics and its differential diagnosis based on CT and MRI were discussed, with several features to help differentiating pancreatic insulinoma from adenocarcinoma in accordance with the current literature. © 2020 The Authors |
Atypical; CT; Insulinoma; MRI |
adult; Article; case report; clinical article; clinical feature; computer assisted tomography; consciousness disorder; contrast enhancement; differential diagnosis; female; histopathology; human; human tissue; insulinoma; laboratory test; nuclear magnetic resonance imaging; pancreas adenocarcinoma; priority journal; seizure |
Elsevier Inc. |
22146245 |
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Article |
Q4 |
117 |
27429 |
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No records
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280 |
Pradita L.W., Kamilla D.N., Soedarsono N., Yunaini L., Auerkari E.I. |
57226576844;57226575340;14049161500;57192911515;10139113000; |
Intron 4 VNTR A/B polymorphism of endothelial nitric oxide synthase gene in periodontitis |
2021 |
Journal of Physics: Conference Series |
1943 |
1 |
012087 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112023901&doi=10.1088%2f1742-6596%2f1943%2f1%2f012087&partnerID=40&md5=a0fb2d74d58911990f7e8f70aaf919b9 |
Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Pradita, L.W., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Kamilla, D.N., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia |
Nitric Oxide (NO) is an important mediator in the inflammatory and immune systems. The eNOS gene is one of the three isoforms of Nitric Oxide Synthase (NOS), which is responsible for synthesizing NO. Periodontitis is an inflammatory disease in periodontal tissue with genetic involvement. Polymorphism in eNOS gene changes the functional aspect of this gene and is associated with several inflammatory diseases including periodontitis. Aim: To detect Endothelial Nitric Oxide Synthase intron 4 gene polymorphism in Indonesian population with periodontitis. Analysis of the Endothelial Nitric Oxide Synthase (eNOS) intron 4 gene polymorphism was observed by carrying out PCR method followed by electrophoresis for the analysis, without the usage of restriction enzyme. The chi-square test and odds ratio were performed for statistical analysis. In this study, there were 34 samples with AA genotype, 3 samples with AB genotype, and 13 samples with BB genotype in periodontitis group. Whereas in the control group, there were 41 samples with AA genotype and 9 samples with BB genotype. AB genotype was absent in the control group. In periodontitis group, there were 71 A alleles and 29 B alleles, and in the control group, 82 A alleles and 18 B alleles were found. Polymorphic genotypes and alleles were found higher in periodontitis sample (32% and 29%) than healthy controls (18%). The polymorphism of eNOS intron 4 was found in periodontitis patients. There is no significant distribution difference was found between the periodontitis patients and the control group. ENOS intron 4 gene polymorphism does not affect the risk of periodontitis. © Published under licence by IOP Publishing Ltd. |
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Electrophoresis; Genes; Nitric oxide; Polymerase chain reaction; Polymorphism; Statistical tests; Endothelial nitric oxide synthase; Endothelial nitric-oxide synthase (eNOS); Functional aspects; Gene polymorphism; Inflammatory disease; Nitric-oxide synthase; Periodontal tissue; Restriction enzymes; Diseases |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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281 |
Gani A.Z., Zahra P.K., Soedarsono N., Yunaini L., Auerkari E.I. |
57222626782;57226565453;14049161500;57192911515;10139113000; |
Vitamin D receptor TaqI (rs731236) gene polymorphism in caries patients |
2021 |
Journal of Physics: Conference Series |
1943 |
1 |
012093 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112014710&doi=10.1088%2f1742-6596%2f1943%2f1%2f012093&partnerID=40&md5=5891ab3c26dbd9bd14c0be24643600b3 |
Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Gani, A.Z., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Zahra, P.K., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia |
Vitamin D receptor (VDR) is included in the type of protein that serves as the biological function regulator of vitamin D. Tooth formation, especially in enamel and dentin calcification, as well as maintaining the balance of phosphate and calcium ions which is an important factor in protecting teeth requires support from vitamin D. The VDR gene will regulate the activity of VDR proteins. Caries is a multifactorial disease in which genetic factors can affect the host susceptibility to caries. Polymorphism in the VDR gene is suspected to affect the host susceptibility to caries through changes in calcium metabolism. This study aims to discover the VDR gene polymorphism and its association with caries patients in Indonesia. 100 DNA samples from 100 blood samples, including 50 dental caries patients and 50 healthy controls, were analyzed using PCR-RFLP technique. PCR products were digested with the TaqI restrictive enzyme, then assessed with statistical analysis using Fisher's exact test and Continuity correction test. In the caries group, there were no samples with CC genotype, 4 samples with CT genotype, and 46 samples with TT genotype. There were also 4 C alleles and 96 T alleles. Polymorphic genotypes and alleles were found higher in the caries group (100% and 96%) than healthy controls (88% and 84%). These results conclude that the polymorphism of VDR TaqI (rs731236) gene was found in patients with dental caries. The distribution of genotypes and allele distributions of VDR TaqI (rs731236) gene between caries and healthy controls significantly differs noticeable (p <0.05). © Published under licence by IOP Publishing Ltd. |
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Biomineralization; Calcium; Polymerase chain reaction; Polymorphism; Proteins; Vitamins; Biological functions; Calcium metabolism; Continuity corrections; Gene polymorphism; Healthy controls; Host susceptibility; Multifactorial disease; Vitamin D receptor; Genes |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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No records
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73 |
Kosasih A., Koepfli C., Dahlan M.S., Hawley W.A., Baird J.K., Mueller I., Lobo N.F., Sutanto I. |
56584346800;26536294400;57195937625;7004280510;15921267800;7006910183;35392948100;6603791639; |
Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study |
2021 |
Malaria Journal |
20 |
1 |
177 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104141748&doi=10.1186%2fs12936-021-03709-y&partnerID=40&md5=9c099fec0d8bce6347bf112092d4561b |
PhD Programme in Biomedical Sciences, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; PT Epidemiologi Indonesia, Jakarta, Indonesia; UNICEF, Jakarta, Indonesia; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Department of Parasitology, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Kosasih, A., PhD Programme in Biomedical Sciences, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Koepfli, C., Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States, Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Dahlan, M.S., PT Epidemiologi Indonesia, Jakarta, Indonesia; Hawley, W.A., UNICEF, Jakarta, Indonesia; Baird, J.K., Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Mueller, I., Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Lobo, N.F., Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; Sutanto, I., Indonesian Medical Education and Research Institute, Jakarta, Indonesia, Department of Parasitology, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Background: A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas—an activity that is expected to reduce local transmission. Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia. Methods: RT-qPCR targeting pfs25 and pvs25 transcripts—gametocyte molecular markers for Plasmodium falciparum and Plasmodium vivax, respectively, was performed to detect and quantify gametocytes in blood samples of P. falciparum and P. vivax-infected subjects over the course of the MST study. The presence of both asexual and sexual parasites in microscopic and submicroscopic infections was compared from the start and end of the MST, using proportion tests as well as parametric and non-parametric tests. Results: Parasite prevalence remained unchanged for P. falciparum (6% = 52/811 versus 7% = 50/740, p = 0.838), and decreased slightly for P. vivax (24% = 192/811 versus 19% = 142/740, p = 0.035) between the MST baseline and endpoint. No significant difference was observed in gametocyte prevalence for either P. falciparum (2% = 19/803 versus 3% = 23/729, p = 0.353, OR = 1.34, 95%CI = 0.69–2.63), or P. vivax (7% = 49/744 versus 5% = 39/704, p = 0.442, OR = 0.83, 95%CI = 0.52–1.31). Even though there was an insignificant difference between the two time points, the majority of parasite positive subjects at the endpoint had been negative at baseline (P. falciparum: 66% = 29/44, P. vivax: 60% = 80/134). This was similarly demonstrated for the transmissible stage—where the majority of gametocyte positive subjects at the endpoint were negative at baseline (P. falciparum: 95% = 20/21, P. vivax: 94% = 30/32). These results were independent of treatment provided during MST activities. No difference was demonstrated in parasite and gametocyte density between both time points either in P. falciparum or P. vivax. Conclusion: In this study area, similar prevalence rates of P. falciparum and P. vivax parasites and gametocytes before and after MST, although in different individuals, points to a negligible impact on the parasite reservoir. Treatment administration based on parasite positivity as implemented in the MST should be reevaluated for the elimination strategy in the community. Trial registration Clinical trials registration NCT01878357. Registered 14 June 2013, https://www.clinicaltrials.gov/ct2/show/NCT01878357. © 2021, The Author(s). |
Gametocyte; Mass screening and treatment; Pfs25; Pvs25 |
dihydroartemisinin plus piperaquine; primaquine; adolescent; Article; blood sampling; cell density; controlled study; disease reservoir; endemic disease; female; gametocyte; gene; gene targeting; genetic transcription; human; Indonesia; longitudinal study; major clinical study; malaria falciparum; male; mass screening; microscopy; parasite clearance; parasite transmission; pfs25 gene; Plasmodium vivax malaria; population structure; prevalence; prospective study; pvs25 gene; randomized controlled trial; real time polymerase chain reaction; adult; aged; child; heterozygote; infant; isolation and purification; malaria falciparum; middle aged; parasitology; Plasmodium falciparum; Plasmodium vivax; Plasmodium vivax malaria; preschool child; very elderly; young adult; Adolescent; Adult; Aged; Ag |
BioMed Central Ltd |
14752875 |
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33836772 |
Article |
Q1 |
1718 |
1764 |
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360 |
Yunir E., Tahapary D.L., Tarigan T.J.E., Harbuwono D.S., Oktavianda Y.D., Kristanti M., Iswati E., Sarumpaet A., Soewondo P. |
36520254800;55944492500;36057746500;36056341600;57224499358;57208222835;57224505254;57193017794;23475336100; |
Non-vascular contributing factors of diabetic foot ulcer severity in national referral hospital of Indonesia |
2021 |
Journal of Diabetes and Metabolic Disorders |
20 |
1 |
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805 |
813 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107722068&doi=10.1007%2fs40200-021-00827-x&partnerID=40&md5=b307a628bc17237466c173d4d63b13aa |
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tahapary, D.L., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tarigan, T.J.E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harbuwono, D.S., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavianda, Y.D., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kristanti, M., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iswati, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sarumpaet, A., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: Diabetic foot ulcer (DFU) is a common chronic complication of type 2 diabetes mellitus (T2DM) in Indonesia, with a prevalence of 7.3%. However, the characteristics of these patients remain unclear. We investigated the characteristics of patients with DFU without peripheral arterial disease (PAD) and analyzed non-vascular factors related to severity of DFU in a tertiary care national referral hospital in Indonesia. Methods: This was a cross-sectional study including 123 hemodynamically stable DFU patients without PAD recruited from Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia from 2010–2015. Results: DFU patients were predominantly over 50 years old (75.6%) and diagnosed with T2DM for 5 years with poor glycemic control (82.7%) and peripheral neuropathy (91.3%). Most patients had anemia (86.7%), leukocytosis (84.6%), and were undernourished, as characterized by a low lipid profile (90.8%) and hypoalbuminemia (83.7%). Most had extensive size of ulcer at the initial visit, with a median size of 16.23 (2.92–60.16) cm2. Ulcers were mostly located of the forefoot (62.5%) and were caused by mechanical trauma (46.2%). Bivariate analysis revealed that significant factors for the development of DFU were related to DFU size, including duration of T2DM (p = 0.04), leukocyte levels (p = < 0.01), and thrombocyte levels (p = < 0.01). Multivariate analysis showed leucocyte (p = 0.03) and thrombocyte (p = 0.023) had significantly correlated with DFU severity. Conclusion: Leucocyte and thrombocyte may be the greatest contributing non-vascular factors for severity of DFU in Indonesia. © 2021, Springer Nature Switzerland AG. |
Diabetic foot ulcer; Leucocyte; Non-vascular factor; Thrombocyte |
adult; anemia; Article; clinical feature; controlled study; correlational study; cross-sectional study; diabetic foot; disease association; disease course; disease duration; disease severity; female; forefoot; glycemic control; hemodynamics; human; hypoalbuminemia; Indonesia; leukocyte count; leukocytosis; lipid analysis; major clinical study; male; malnutrition; non insulin dependent diabetes mellitus; peripheral neuropathy; platelet count; tertiary care center |
Springer Science and Business Media Deutschland GmbH |
22516581 |
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Article |
Q2 |
619 |
8164 |
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627 |
Aninditha T., Pratama P.Y., Sofyan H.R., Imran D., Estiasari R., Octaviana F., Iskandar M.M., Odilo J., Werdhani R.A., Aman R.A., Ranakusuma T.A.S. |
57189611205;57450416000;57328366500;57203976849;55240204000;26029958700;57205414462;57450963600;57189088848;36848942500;7801656487; |
Adults brain tumor in Cipto Mangunkusumo General Hospital: A descriptive epidemiology |
2021 |
Romanian Journal of Neurology/ Revista Romana de Neurologie |
20 |
4 |
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480 |
484 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124554663&doi=10.37897%2fRJN.2021.4.13&partnerID=40&md5=b5302d49e5e258bb7f13476b33682fdc |
Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia; Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia |
Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Pratama, P.Y., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Sofyan, H.R., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Imran, D., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Estiasari, R., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Octaviana, F., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Iskandar, M.M., Department of Neurology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia; Odilo, J., Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Aman, R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Ranakusuma, T.A.S., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia |
Background. Brain tumor is a rare tumor with low incidence. Although it is a rare tumor, the mortality of brain tumor is disproportionately high. Many countries have already published epidemiology of brain tumor. However, the epidemiology of brain tumor in Indonesia remains to be investigated. This article aimed to provide descriptive epidemiology of brain tumor. Methods. The data of brain tumor acquired from Department of Neurology and Neurosurgery Cipto Mangunkusumo General Hospital from 2014 to 2016. The histopathology classification of primary intracranial tumors was based on WHO classification of CNS tumors 2016 while brain metastasis was classified based on other histopathological types. The vari-ables were analyzed and presented descriptively. Results. There were 316 subjects acquired in this study. Most of the subjects (68%) were women. The mean age of this study was 43.8 (11.7). Most of the subjects (86.1%) had primary histopathology. Lung cancer was the most commonly found brain metastasis in this study (34.1%). Conclusions. This is a pilot study of brain tumor epidemiology in Indonesia. Collaboration with other centers in Indonesia is needed to give a more representative insight of brain tumor in Indonesia. © 2021, Editura Medicala. All rights reserved. |
Brain tumor; Cancer; Descriptive study; Epidemiology |
adenoma; adult; Article; brain hemorrhage; brain metastasis; brain tumor; cancer grading; cancer localization; cancer staging; central nervous system tumor; cross-sectional study; female; general condition; general hospital; glioblastoma; glioma; histopathology; human; human tissue; immunohistochemistry; intracranial metastasis; intracranial tumor; lung cancer; major clinical study; male; meningioma; middle aged; neurosurgery; pilot study; retrospective study |
Editura Medicala |
20696094 |
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Article |
Q4 |
111 |
28569 |
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756 |
Triwijoyo B.K., Sabarguna B.S., Budiharto W., Abdurachman E. |
57193868829;56028625800;36069151100;56820169100; |
New Hypertensive Retinopathy Grading Based on the Ratio of Artery Venous Diameter from Retinal Image |
2021 |
International Journal of Computing |
20 |
2 |
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221 |
227 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110495692&doi=10.47839%2fijc.20.2.2069&partnerID=40&md5=c4614e9182f0c78a92851c2aaa71bc36 |
Binus Graduate Program Bina Nusantara University, Jl. Kebon Jeruk No.27, Jakarta, Indonesia; Department of Computer Science, Faculty of Engineering and Health, Bumigora University, Jl. Ismail Marzuki,West Nusa Tenggara, Mataram, Indonesia; Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jl. Pegangsaan Timur, Central Jakarta City, Indonesia |
Triwijoyo, B.K., Binus Graduate Program Bina Nusantara University, Jl. Kebon Jeruk No.27, Jakarta, Indonesia, Department of Computer Science, Faculty of Engineering and Health, Bumigora University, Jl. Ismail Marzuki,West Nusa Tenggara, Mataram, Indonesia; Sabarguna, B.S., Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jl. Pegangsaan Timur, Central Jakarta City, Indonesia; Budiharto, W., Binus Graduate Program Bina Nusantara University, Jl. Kebon Jeruk No.27, Jakarta, Indonesia; Abdurachman, E., Binus Graduate Program Bina Nusantara University, Jl. Kebon Jeruk No.27, Jakarta, Indonesia |
Medical research indicated that narrowing of the retinal blood vessels might be an early indicator of cardiovascular diseases; one of them is hypertensive retinopathy. This paper proposed the new staging method of hypertensive retinopathy by measure the ratio of diameter artery and vein (AVR). The dataset used in this research is the public Messidor color fundus image dataset. The proposed method consists of image resizing using bicubic interpolation, optic disk detection, a region of interest computation, vessel diameter measuring, AVR calculation, and grading the new categories of Hypertensive Retinopathy based on Keith-Wagener-Barker categories. The experiments show that the proposed method can determine the stage of hypertensive retinopathy into new categories. © 2021. All Rights Reserved. |
artery-vein diameter ratio; grading; hypertensive retinopathy |
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Research Institute of Intelligent Computer Systems |
17276209 |
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Article |
Q3 |
184 |
20423 |
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785 |
Kartini D., Taher A., Panigoro S., Setiabudy R., Jusman S., Haryana S., Murdani A., Rustamadji P., Karisyah A., Rasyid S. |
57215490523;7005269743;56790104300;6602316235;36518792100;6507708439;57224770678;55321572200;57224765948;57224779056; |
Melatonin effect on hypoxia inducible factor-1a and clinical response in patients with oral squamous cell carcinoma receiving neoadjuvant chemotherapy: A randomized controlled trial |
2021 |
Journal of Carcinogenesis |
20 |
1 |
5 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108295574&doi=10.4103%2fjcar.JCar_19_20&partnerID=40&md5=7ba744b8de3c6ab6a11dd7b89d27e34a |
Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kartini, D., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Panigoro, S., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusman, S., Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haryana, S., Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Murdani, A., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rustamadji, P., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karisyah, A., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, S., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Context: Chemoresistance is a major issue in patients with locally advanced oral squamous cell carcinoma (OSCC). In this study, we evaluated the effectiveness of melatonin in conjunction with neoadjuvant chemotherapy (NC) on hypoxia-inducible factor-1α (HIF-1α) expression and clinical response in locally advanced OSCC patients. Aims: To study the effects of melatonin on HIF-1α expression and its effect on the clinical response of patients with locally advanced OSCC. Settings and Design: A randomized controlled trial was conducted, wherein patients were recruited from several hospitals in Jakarta, Indonesia. Patients were randomized into two groups using computerized block randomization. Subjects and Methods: Both groups were given NC, with treatment group receiving melatonin. Outcomes measured in this study were HIF-1α expression from tissue samples and clinical response based on the RECIST 1.1 criteria. Twenty-five patients completed the study protocol and were included in the data analysis. Statistical Analysis Used: Shapiro-Wilk test was used to test the data normality. For data with normal distribution, we conducted an independent t-test to compare between the two groups. Data with abnormal distribution were analyzed using Mann-Whitney U-test. The mean difference between the two groups was analyzed using Shapiro-Wilk normality test. Results: Our study showed a significant decrease in HIF-1α expression in the melatonin group compared to the placebo group (P < 0.05, relative risk 3.08). However, the degree of reduction of HIF-1α expression in the melatonin group did not differ significantly (P = 0.301). Conclusions: Our study showed that melatonin administered at 20 mg/day could reduce the expression of HIF-1α and residual tumor percentage, but did not affect the clinical response in OSCC patients. © 2021 Annual Reviews Inc.. All rights reserved. |
Chemoresistance; hypoxia-inducible factor-1α; melatonin; oral squamous cell carcinoma |
carboplatin; cisplatin; docetaxel; fluorouracil; hypoxia inducible factor 1alpha; melatonin; messenger RNA; placebo; adult; advanced cancer; adverse drug reaction; aged; Article; cancer combination chemotherapy; cancer patient; cancer staging; cancer tissue; clinical article; clinical outcome; comparative study; computerized block randomization; controlled study; data analysis software; double blind procedure; drowsiness; fatigue; female; headache; human; human tissue; incisional biopsy; Indonesia; Karnofsky Performance Status; male; microcapsule; mouth squamous cell carcinoma; neoadjuvant chemotherapy; parallel design; protein expression; randomization; randomized controlled trial; real time polymerase chain reaction; response evaluation criteria in solid tumors; risk factor; sleep disord |
Wolters Kluwer Medknow Publications |
09746773 |
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Article |
Q1 |
2771 |
735 |
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804 |
Wicaksana P., Kurniati N., Pardede S. |
57193446457;36473260300;57210394278; |
Dyslipidemia among HIV-positive children receiving antiretroviral therapy in Indonesia |
2021 |
HIV and AIDS Review |
20 |
1 |
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46 |
51 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106294127&doi=10.5114%2fhivar.2021.105086&partnerID=40&md5=1f2028e2d19b8667b0fe6419e86d0dfd |
Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Wicaksana, P., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Kurniati, N., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Pardede, S., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Introduction: Antiretroviral (ARV) therapy has changed the status of human immunodeficiency virus (HIV) infection from a high-mortality disease into a chronic one. One of the consequences of long-term use of ARV medications is dyslipidemia, which may progress to cardiovascular disease in the future. The aim of the study was to measure the rate of dyslipidemia among HIV-infected children receiving ARV therapy and related risk factors. Material and methods: A cross-sectional study was conducted at pediatric outpatient clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from January to July 2019. Lipid profile was examined on 96 eligible subjects and data regarding nutritional status, clinical stage at diagnosis, latest immunosuppression status, latest viral load (VL) value, and latest ARV combination used were obtained from medical records. Bivariate and multivariate analysis were performed to find the association between dependent and independent variables using SPSS version 22. Results: Of 96 subjects included, 52 (54.2%) subjects experienced dyslipidemia. The prevalence of dyslipidemia among those with second-line (containing protease inhibitors) and first-line (containing non-nucleoside reverse transcriptase inhibitors) ARV therapy were 80% and 39%, respectively. The use of second-line ARV therapy was associated with 6.3 times (p < 0.01; 95% CI: 2.4-17.1) increased risk of dyslipidemia compared to first-line ARV therapy. Conclusions: Prevalence of dyslipidemia among HIV-positive children on ARV was high with second-line ARV therapy being a risk factor. © 2021 Termedia Publishing House Ltd.. All rights reserved. |
Children; Dyslipidemia; HAART; HIV; Protease inhibitors |
abacavir; antiretrovirus agent; cholesterol; efavirenz; emtricitabine; high density lipoprotein; lamivudine; lopinavir plus ritonavir; low density lipoprotein; nevirapine; tenofovir; triacylglycerol; zidovudine; adolescent; Article; child; controlled study; cross-sectional study; dyslipidemia; female; highly active antiretroviral therapy; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; hypertriglyceridemia; immune deficiency; Indonesia; lipid fingerprinting; major clinical study; male; nutritional status; pediatric hospital; preschool child; prevalence; school child; virus load |
Termedia Publishing House Ltd. |
17301270 |
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Article |
Q4 |
156 |
22602 |
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