No records
|
823 |
Sarika D.T., Louisa M., Rozaliyani A., Evelina, Susiyanti M. |
57223018187;41461551400;57203065912;57223007552;19640377300; |
Efficacy of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole in aspergillus fumigatus-induced moderate fungal keratitis in rabbits |
2021 |
Medical Journal of Indonesia |
30 |
1 |
|
13 |
19 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104464172&doi=10.13181%2fmji.oa.203726&partnerID=40&md5=6021b6878c47eb4ccde69bba65f51abb |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sarika, D.T., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Evelina, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Susiyanti, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND There is no in vivo evidence for the effectiveness of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole (VCZ) for treating Aspergillus fumigatus keratitis. This study aimed to compare the efficacy of both agents against it. METHODS A randomized, masked, controlled experimental study was conducted on 11 albino New Zealand white rabbits in which moderate fungal keratitis was induced by inoculating spores of A. fumigatus to the cornea. The rabbits were allocated into 3 groups: 50 μg/0.1 ml intrastromal VCZ injection, 50 μg/0.1 ml intrastromal and intracameral VCZ injections, and topical VCZ (control). The treatment was given 5 days after inoculation. Epithelial defect, infiltrate size, corneal ulcer depth, and hypopyon were evaluated clinically. Histopathological and mycological examinations were also done 14 days after treatment. RESULTS All rabbits in the adjuvant treatment groups demonstrated a tendency of a better clinical response with decreasing size of epithelial defect (p = 0.679) and infiltrate (p = 0.755) than in the control group. Direct microscopy, corneal culture, and chop corneal tissue culture were still positive in most of the rabbits from all groups. Histopathological examination showed an increase of inflammatory cells after treatment in all groups, especially in rabbits which were inoculated with A. fumigatus spores in both eyes. CONCLUSIONS An adjuvant combination of intrastromal and intracameral VCZ showed a tendency of better clinical response for A. fumigatus-induced moderate fungal keratitis in rabbits. © 2021 Authors. |
Aspergillus fumigatus; Fungal keratitis; Intrastromal; Voriconazole |
eye drops; ketamine; pentobarbital; potassium hydroxide; prednisone acetate; tetracaine; voriconazole; xylazine; animal experiment; animal model; animal tissue; Article; Aspergillus fumigatus; controlled study; cornea injury; cornea ulcer; corneal scraping; disk diffusion; drug efficacy; follow up; fungal examination; histopathology; hypopyon; inflammation; intrastromal drug administration; keratectomy; keratomycosis; Leporidae; male; nonhuman; treatment response |
Faculty of Medicine, Universitas Indonesia |
08531773 |
|
|
Article |
Q4 |
164 |
21905 |
|
|
843 |
Nelson B., Sitohang I.B.S., Marissa M., Indriatmi W., Wisnu W. |
57222619613;56734569200;57210795916;57189888041;57200425452; |
A comparative study of melasma severity after hyperthyroid therapy in hyperthyroid subjects with melasma |
2021 |
Acta Dermatovenerologica Alpina, Pannonica et Adriatica |
30 |
1 |
|
31 |
34 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103497112&doi=10.15570%2factaapa.2021.7&partnerID=40&md5=12823fac55643be95fa3cbe943888df6 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Metabolic Endocrine Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Nelson, B., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wisnu, W., Metabolic Endocrine Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Melasma, and its variant chloasma, is an acquired and chronic disorder of hyperpigmentation, characterized by symmetrical hypermelanoses of the face. The exact pathogenesis of melasma remains unclear. Several hormones are thought to play a role, including thyroid hormones. The study’s objectives are to determine the proportion of melasma cases in hyperthyroid patients and to compare the severity of melasma before and after medications of hyperthyroid therapy. Methods: A quasi-experimental (pre-post intervention) study was conducted in Jakarta from August 2019 to February 2020. Twenty-three patients either newly diagnosed with hyperthyroidism or that had undergone hyperthyroid therapy for a maximum of 3 months and also had melasma were recruited. The severity of melasma was scored with the modified Melasma Area and Severity Index (mMASI), and dermoscopy of the lesions was performed. The evaluation was performed after 3 months of hyperthyroid therapy. Results: Among the 69 hyperthyroid patients, 45 (65%) had melasma. The mean difference in the mMASI score was 0.49 (p > 0.05). Dermoscopy features did not show any differences between the start and end of the study. Conclusions: There is no significant improvement of melasma severity in hyperthyroid patients after 3 months of hyperthyroid therapy. © 2021, Slovene Medical Society. All rights reserved. |
Chloasma; Hyperthyroid; Melasma; MMASI |
retinol derivative; thiamazole; thyrotropin; adult; anticonvulsant therapy; Article; chloasma; clinical article; clinical examination; comparative study; disease severity; disease severity assessment; epiluminescence microscopy; euthyroidism; female; free thyroxine index; hormonal contraception; hormone substitution; human; hyperpigmentation; hyperthyroidism; melasma area and severity index; prospective study; scoring system; skin defect; telangiectasia; thyroid function; thyroxine blood level; face; hyperthyroidism; melanosis; treatment outcome; Face; Humans; Hyperthyroidism; Melanosis; Treatment Outcome |
Slovene Medical Society |
13184458 |
|
33765755 |
Article |
#N/A |
#N/A |
#N/A |
|
|
900 |
Pulungan A.B., Fadiana G., Annisa D. |
57192905981;57221614963;57205770955; |
Type 1 diabetes mellitus in children: Experience in Indonesia |
2021 |
Clinical Pediatric Endocrinology |
30 |
1 |
|
11 |
18 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099564628&doi=10.1297%2fcpe.30.11&partnerID=40&md5=aba5de1c98be7c8ac4cc9cdd9a7ff21b |
Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Pulungan, A.B., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Fadiana, G., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Annisa, D., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The prevalence of type 1 diabetes mellitus (T1DM) in children in Indonesia is increasing although the real number is unknown due to high rate of misdiagnosis. Public and healthcare awareness on T1DM in children is still low, reflected by the high number of children diagnosed with diabetic ketoacidosis (DKA). The Indonesian Pediatric Society (IPS) had published a guideline on T1DM management, which consists of insulin injection, daily monitoring of blood glucose, nutrition, physical activity, and education. Aside from low awareness, current challenges on T1DM management in Indonesia are funding by the national health insurance, fasting during Ramadan, and inequities on DM care. The involvement of society, healthcare workers, stakeholders, and the government is of importance to ensure optimal management for children with diabetes. © 2021 by The Japanese Society for Pediatric Endocrinology. |
Children; Diabetes; Indonesia; Type 1 diabetes mellitus (T1DM) |
hemoglobin A1c; immunologic factor; insulin; vitamin D; awareness; blood glucose monitoring; blurred vision; body mass; body weight loss; caloric intake; carbohydrate intake; clinical article; diabetic ketoacidosis; diabetic retinopathy; education; endocrinologist; epigenetics; food intake; glucose blood level; glycemic control; health care personnel; health insurance; health survey; human; hyperglycemia; hyperphagia; hypertension; hypocalcemia; hypoglycemia; insulin dependent diabetes mellitus; insulin resistance; insulin sensitivity; insulin treatment; insulinoma; ketoacidosis; ketonuria; metabolic regulation; microalbuminuria; national health insurance; nocturia; non insulin dependent diabetes mellitus; nutrition; obesity; oral glucose tolerance test; pediatrician; physical activity; po |
Jeff Corporation Co. Ltd |
09185739 |
|
|
Review |
Q2 |
461 |
10790 |
|
|
No records
|
1 |
Widaty S., Sutarjo A.S., Wahid M.H., Darmawan I., Sitohang I.B.S. |
57208261546;57221634021;57192887722;57395174200;56734569200; |
The association between Malassezia spp. And pruritus in facial acne vulgaris |
2021 |
Journal of Pakistan Association of Dermatologists |
31 |
3 |
|
391 |
397 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122215594&partnerID=40&md5=d681f660e92c0b469e87702a23617193 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Dharmais Cancer Hospital-National Cancer Center, Jakarta, Indonesia; Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sutarjo, A.S., Department of Dermatology and Venereology, Dharmais Cancer Hospital-National Cancer Center, Jakarta, Indonesia; Wahid, M.H., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Darmawan, I., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background Acne vulgaris (AV) is a chronic inflammatory condition involving the pilosebaceous unit. Recent studies have shown that itching of mild-to-moderate severity is relatively common in patients with acne. Malassezia spp. is normal flora of skin surface, and can be found in acne lesions. Aim: To clarify the relationship between Malassezia spp. in facial acne lesions and their association with pruritus symptom. Methods This is a cross-sectional study conducted at dermatology and venereology outpatient clinic in a tertiary hospital in Indonesia. We recruited subjects with at least four inflammatory and four noninflammatory facial acne lesions. Acne was graded using Lehmann's criteria, and pruritus was graded using visual analog scale (VAS). Follicular content of acne lesions was collected for microscopic examination and fungal culture. Results Of the 120 subjects, 46 (38.3%) reported experiencing itching in acne lesions. Pruritus was more common in patients with mild AV. Among those with pruritus, fungal spore was found in 60.6% subjects. There was no statistically significant difference in terms of the presence and severity of pruritus and presence of Malassezia spp. determined by culture (p=0.332; 0.317). Conclusion Pruritus may accompany facial acne lesions. In this study, the presence and severity of pruritus did not correlate with the presence of Malassezia spp. in facial acne lesions. © 2021 Pakistan Association of Dermatologists. All rights reserved. |
Acne vulgaris; Fungal spores; Malassezia; Pruritus; Skin disease |
anti acne agent; acne vulgaris; adolescent; adult; Article; controlled study; cross-sectional study; disease association; disease severity; female; fungus culture; fungus spore; human; human tissue; Indonesia; major clinical study; Malassezia; male; microscopy; nonhuman; outpatient department; skin pruritus; tertiary care center; visual analog scale |
Pakistan Association of Dermatologists |
15609014 |
|
|
Article |
Q4 |
129 |
25503 |
|
|
180 |
Marwali E.M., Rayhan M., Roebiono P.S. |
36608535400;57219904946;57192895321; |
Nitroglycerin inhalation for acute treatment of pulmonary arterial hypertension in children with congenital heart disease |
2021 |
Cardiology in the Young |
31 |
9 |
|
1381 |
1385 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107847583&doi=10.1017%2fS1047951121002092&partnerID=40&md5=7d11731cfb6493c4e772840e615e164a |
Pediatric Cardiac Intensive Care Division, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia |
Marwali, E.M., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Roebiono, P.S., Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia |
Abstract Objectives: Acute pulmonary hypertension and pulmonary hypertensive crisis may result in adverse clinical outcomes if unsuccessfully treated. Inhaled nitric oxide has long been considered as the standard pharmacotherapy for acute pulmonary hypertension, but lack of feasibility in some settings and evidences challenging its benefits lead to the use of alternative treatment, amongst which is nitroglycerin inhalation. The purpose of this review article is to discuss available data on the use of nitroglycerin inhalation for acute treatment of pulmonary hypertension in children with CHD and its potential benefit in post-operative setting. Data sources: Literatures included in this review were acquired by searching in PubMed online database. Keywords used were Pulmonary Hypertension, Congenital heart defects, Pediatrics, Inhaled nitroglycerin, and its synonyms. Study selection: Title and abstract were screened to select relevant literatures including the three paediatric clinical trials on nitroglycerin inhalation. Critical appraisal of the clinical trials was then done using the University of Oxford Centre of Evidence-Based Medicine Critical Appraisal Tools. Conclusions: Paediatric studies showed the benefit of nitroglycerin inhalation in uncorrected cases of CHD during catheterisation procedures. Until recently, there have been no studies conducted in paediatric post-operative CHD cases. Further study is required to provide evidence for inhaled nitroglycerin use in this setting including the appropriate dosing and potential side effects with repeated administration, © |
aerosolised nitroglycerin; congenital heart disease; corrective surgery; exogenous nitric oxide; Nitroglycerin inhalation; pulmonary arterial hypertension |
glyceryl trinitrate; nitric oxide; phosphodiesterase V inhibitor; prostacyclin; prostacyclin derivative; prostaglandin E1; glyceryl trinitrate; clinical trial (topic); congenital heart disease; drug safety; emergency care; evidence based practice; heart catheterization; human; postoperative care; publication; pulmonary hypertension; Review; child; complication; congenital heart malformation; inhalational drug administration; pulmonary hypertension; Administration, Inhalation; Child; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Nitroglycerin; Pulmonary Arterial Hypertension |
Cambridge University Press |
10479511 |
|
34082850 |
Review |
Q3 |
386 |
12454 |
|
|
225 |
Tandaju J.R., Ii W., Barati-Boldaji R., Raeisi-Dehkordi H. |
57222662533;57226738113;57204935735;57195065694; |
Meta-analysis of statin and outcomes of coronavirus disease 2019 (COVID-19): Reconsideration is needed |
2021 |
Nutrition, Metabolism and Cardiovascular Diseases |
31 |
9 |
|
2737 |
2739 |
|
3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112531675&doi=10.1016%2fj.numecd.2021.06.009&partnerID=40&md5=51cf1abe5238935b3bcbca2d4b7a9969 |
Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
Tandaju, J.R., Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; Ii, W., The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Barati-Boldaji, R., Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Raeisi-Dehkordi, H., Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
[No abstract available] |
|
hydroxymethylglutaryl coenzyme A reductase inhibitor; human; COVID-19; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; SARS-CoV-2 |
Elsevier B.V. |
09394753 |
|
34366177 |
Letter |
Q1 |
1127 |
3665 |
|
|
277 |
Sigit F.S., Trompet S., Tahapary D.L., Sartono E., Willems van Dijk K., Yazdanbakhsh M., Supali T., Smit J.W.A., Rosendaal F.R., de Mutsert R. |
57213595986;22954837300;55944492500;6701506022;57202571815;7006269286;6602742029;24577861400;7004174530;16042051400; |
The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population |
2021 |
Nutrition, Metabolism and Cardiovascular Diseases |
31 |
8 |
|
2426 |
2435 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108275064&doi=10.1016%2fj.numecd.2021.05.012&partnerID=40&md5=b98f561673afb80c486c693b20480984 |
Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Parasitology, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
Sigit, F.S., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Trompet, S., Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Tahapary, D.L., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Sartono, E., Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Willems van Dijk, K., Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Yazdanbakhsh, M., Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Supali, T., Department of Parasitology, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Smit, J.W.A., Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands; Rosendaal, F.R., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; de Mutsert, R., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands |
Background and aims: At the same BMI, Asian populations develop cardiometabolic complications earlier than Western populations. We hypothesized that a different secretion of the adipocyte-derived hormones leptin and adiponectin plays a role and investigated the associations of the two hormones with the metabolic syndrome (MetS) in an Indonesian and a Dutch population. Methods and results: We performed cross-sectional analyses of the Netherlands Epidemiology of Obesity Study (n = 6602) and the SUGAR Scientific Programme Indonesia–Netherlands Study (n = 1461). We examined sex-stratified associations of leptin and adiponectin with MetS, using multivariate logistic regression including adjustment for total body fat. The mean (SD) leptin (mcg/L) were 4.7 (6.0) in Indonesian men, 18.6 (12.0) in Indonesian women, 9.1 (7.7) in Dutch men, and 23.4 (17.4) in Dutch women. The mean (SD) adiponectin (mg/L) were 5.7 (5.4), 7.5 (7.1), 6.6 (3.3), and 11.3 (4.9), respectively. Within the same BMI category, leptin concentrations were similar in the two populations, whereas adiponectin was lower in the Indonesian population. Per SD of leptin, adjusted prevalence odds ratios (ORs, 95%CI) of MetS were 0.9 (0.6–1.2) in Indonesian men, 1.1 (0.9–1.4) in Indonesian women, 2.2 (1.6–2.8) in Dutch men, and 1.2 (1.0–1.5) in Dutch women. Per SD of adiponectin, the ORs were 0.9 (0.7–1.2), 0.8 (0.7–1.0), 0.6 (0.6–0.8), and 0.4 (0.4–0.5), respectively. Conclusions: Despite lower adiponectin levels, adiponectin was not related to the MetS in the Indonesian population and can not explain their increased cardiometabolic risk at the same BMI. © 2021 The Author(s) |
Adiponectin; Asian; Leptin; The metabolic syndrome (MetS); Total body fat; Western |
adiponectin; ADIPOQ protein, human; biological marker; LEP protein, human; leptin; adolescent; adult; aged; blood; body mass; clinical trial; comparative study; cross-sectional study; female; human; Indonesia; male; metabolic syndrome X; middle aged; multicenter study; Netherlands; obesity; prevalence; randomized controlled trial (topic); risk assessment; sex factor; very elderly; young adult; Adiponectin; Adiposity; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Body Mass Index; Cardiometabolic Risk Factors; Cross-Sectional Studies; Female; Humans; Indonesia; Leptin; Male; Metabolic Syndrome; Middle Aged; Netherlands; Prevalence; Randomized Controlled Trials as Topic; Risk Assessment; Sex Factors; Young Adult |
Elsevier B.V. |
09394753 |
|
34154890 |
Article |
Q1 |
1127 |
3665 |
|
|
327 |
Pranata R., Vania A., Vania R., Victor A.A. |
57201973901;57215722420;57208328436;57191055282; |
Intravitreal ranibizumab versus dexamethasone implant in macular edema due to branch retinal vein occlusion: Systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
31 |
4 |
|
1907 |
1914 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089198137&doi=10.1177%2f1120672120947595&partnerID=40&md5=2317b4b6003baf17ce61244daa301bb4 |
Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Universitas Kristen Krida WacanaWest Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, National General Hospital, Jakarta, Daerah Istimewa Jakarta, Indonesia |
Pranata, R., Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Vania, A., Universitas Kristen Krida WacanaWest Jakarta, Indonesia; Vania, R., Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, National General Hospital, Jakarta, Daerah Istimewa Jakarta, Indonesia |
Purpose: Intravitreal ranibizumab (RNB) and dexamethasone intravitreal implant (DII) were developed in the recent past and has been widely used for macular edema secondary to BRVO. We aimed to assess the efficacy and safety of intravitreal ranibizumab (RNB) compared to dexamethasone intravitreal implant (DII) in patients with macular edema secondary to branch retinal vein occlusion (BRVO). Methods: We performed a comprehensive search on topics that assess RNB and DII in patients with macular edema secondary to BRVO from several electronic databases. Results: There were 678 subjects from five studies. Ranibizumab was associated with a greater increase in best-corrected visual acuity (BCVA; mean difference 9.13, I2: 0%) compared to DII. Ranibizumab also demonstrated a greater ⩾10 (OR 2.76, I2: 0%) and ⩾15 letters (OR 2.78, I2: 0%) gain. RNB has better BCVA (logMAR scale) improvement at 6 months’ follow up (mean difference −0.15, I2: 64%) in favor of RNB. Higher IOP was found in DII group on follow-up (mean difference −2.92, I2: 89%) and RNB has lesser IOP ⩾10 mmHg increase compared to DII (OR 0.08, I2: 0%). Cataract formation and/or progression was less in RNB (OR 0.53, I2: 75%). The need for rescue laser was similar the two groups. Conclusion: Intravitreal RNB was more effective with less pronounced effect on IOP and cataract formation and/or progression compared to DII for patients with macular edema secondary to BRVO. © The Author(s) 2020. |
branch retinal vein occlusion; dexamethasone; Intravitreal; macular edema; ranibizumab |
dexamethasone; ranibizumab; angiogenesis inhibitor; dexamethasone; glucocorticoid; ranibizumab; Article; best corrected visual acuity; branch retinal vein occlusion; cataract extraction; central retinal thickness; comparative effectiveness; controlled study; cost effectiveness analysis; disease exacerbation; drug safety; Early Treatment Diabetic Retinopathy Study; follow up; human; intervention study; intraocular pressure; macular edema; meta analysis; qualitative analysis; quality control; randomized controlled trial (topic); retina vein occlusion; retinal thickness; sensitivity analysis; systematic review; visual acuity; complication; intravitreal drug administration; macular edema; retina vein occlusion; treatment outcome; Angiogenesis Inhibitors; Dexamethasone; Glucocorticoids; Humans; |
SAGE Publications Ltd |
11206721 |
|
32757629 |
Article |
Q2 |
790 |
6120 |
|
|
425 |
Pranata R., Vania R., Victor A.A. |
57201973901;57208328436;57191055282; |
Statin reduces the incidence of diabetic retinopathy and its need for intervention: A systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
31 |
3 |
|
1216 |
1224 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086325738&doi=10.1177%2f1120672120922444&partnerID=40&md5=f6079c079179ae3f2ecc748426833463 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Vitreo-Retinal Division, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Victor, A.A., Vitreo-Retinal Division, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Purpose: We aimed to perform a systematic literature search on the latest evidence of the role of statin in reducing diabetic retinopathy and its need for intervention. Methods: A comprehensive search on cohort studies/clinical trials that assess statins and diabetic retinopathy up until August 2019 was performed. The outcome measured was the incidence of diabetic retinopathy and its need for intervention. Results: There were 558.177 patients from six studies. Statin was associated with a lower incidence of diabetic retinopathy (hazard ratio: 0.68 (0.55, 0.84), p < 0.001; I2: 95%). For the subtypes of diabetic retinopathy, statin lowers the incidence of proliferative diabetic retinopathy (hazard ratio: 0.69 (0.51, 0.93), p = 0.01; I2: 90%), non-proliferative diabetic retinopathy (hazard ratio: 0.80 (0.66, 0.96), p = 0.02; I2: 93%), and diabetic macular edema (hazard ratio: 0.56 (0.39, 0.80), p = 0.002; I2: 82%). Statin was associated with a reduced need for retinal laser treatment with a hazard ratio of 0.70 (0.64, 0.76) (p < 0.001; I2: 0%), intravitreal injection with a hazard ratio of 0.82 (0.79, 0.85) (p < 0.001; I2: 0%), and vitrectomy with a hazard ratio of 0.64 (0.48, 0.85) (p < 0.001; I2: 75%). Overall, statin was associated with a reduced need for intervention for diabetic retinopathy with a hazard ratio of 0.72 (0.64, 0.80) (p < 0.001; I2: 73%). The regression-based Egger’s test showed statistically significant small-study effects for non-proliferative diabetic retinopathy (p = 0.011) outcomes. Conclusion: Statin was associated with a decreased risk of diabetic retinopathy and its subtypes. Statin also reduced the need for intervention with retinal laser treatment, intravitreal injection, and vitrectomy. © The Author(s) 2020. |
Diabetic maculopathy; diabetic retinopathy; intravitreal injection; retinal laser treatment; statin; vitrectomy |
hydroxymethylglutaryl coenzyme A reductase inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; Article; clinical trial (topic); diabetic macular edema; diabetic retinopathy; hazard ratio; human; incidence; intravitreal drug administration; low level laser therapy; meta analysis; non insulin dependent diabetes mellitus; nonproliferative diabetic retinopathy; proliferative diabetic retinopathy; prospective study; sensitivity analysis; systematic review; vitrectomy; diabetes mellitus; diabetic retinopathy; incidence; macular edema; Diabetes Mellitus; Diabetic Retinopathy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Intravitreal Injections; Macular Edema; Vitrectomy |
SAGE Publications Ltd |
11206721 |
|
32530705 |
Article |
Q2 |
790 |
6120 |
|
|
442 |
Legiawati L., Raissa, Santoso I.D., Lubis F.F. |
57202804484;57240272100;57219513443;57239954700; |
Comparison between clinical diagnosis with and without dermoscopy in the assessment of hair disorders |
2021 |
Journal of Pakistan Association of Dermatologists |
31 |
2 |
|
201 |
205 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113937212&partnerID=40&md5=c56b73079d0a2b354502f693b7d4fa6e |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Tarumanegara, Jakarta, Indonesia |
Legiawati, L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Raissa, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Santoso, I.D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Tarumanegara, Jakarta, Indonesia; Lubis, F.F., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background: Hair dermoscopy or trichoscopy is a tool used to find hair abnormalities more clearly. Morphologic feature of skin and hair abnormalities becomes more visible under this tool compared with naked eye. It helps to diagnose hair disorders faster and can be used for follow up treatment in patients. The purpose of this study is to compare superiority between clinical diagnosis alone and with addition of dermoscopy tool in the assessment of hair disease. Methods: Research was conducted in October 2018 in a boarding school in West Java, Indonesia. This was a cross-sectional descriptive study. Statistical analysis was done using SPSS Statistics 20.0. Data were collected from 127 subjects through anamnesis, general physical examination and dermatological findings, pull test, dermoscopy, and photographs of scalp and hair lesions. Results: The highest incidence of hair disorder in this study found by clinical examination and dermoscopy was pediculosis capitis, with a total of 86 subjects (67.7%). From the comparison between clinical examination and dermoscopy, we found that dermoscopy was superior for diagnosis. As much as 43 cases of hair disorders which were not detected on clinical examination screening were found by dermoscopy. Out of 127 children, there were 49 subjects with hair disorders found in clinical examination and 92 subjects found by dermoscopy. Conclusion: Dermoscopy as a non-invasive tool which plays an important role in determining the diagnosis of hair disorder. © 2021 Pakistan Association of Dermatologists. All rights reserved. |
Dermoscopy; Diagnosis; Hair disease; Lice infestations; Pediculosis capitis |
adolescent; alopecia; Article; child; clinical examination; controlled study; cross-sectional study; descriptive research; epiluminescence microscopy; female; hair; hair disease; human; Indonesia; major clinical study; male; pediculosis capitis; scar; sebaceous nevus; seborrheic dermatitis |
Pakistan Association of Dermatologists |
15609014 |
|
|
Article |
Q4 |
129 |
25503 |
|
|