No records
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324 |
Lazarus G., Suhardi I.P., Wiyarta E., Rasyidah R.A., Barliana J.D. |
57214599425;57222253831;57221521342;57222252100;57200964187; |
Is there a need to reconsider the use of metformin in COVID-19 patients with type 2 diabetes mellitus? |
2021 |
International Journal of Diabetes in Developing Countries |
41 |
3 |
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377 |
382 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102035672&doi=10.1007%2fs13410-021-00924-w&partnerID=40&md5=6553878fa250ce9823f68e0c2659a9ff |
Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Suhardi, I.P., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Rasyidah, R.A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Barliana, J.D., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Diabetes has been linked with poorer outcomes in coronavirus disease (COVID-19) patients. However, the question to whether continue or withdraw metformin therapy in COVID-19 patients with type 2 diabetes mellitus remains contentious. This study aims to investigate the association between metformin and poor COVID-19 outcomes. Methods: Eligible studies published up to 21 October 2020 were included and appraised for validity, importance, and applicability. The included studies were further ranked according to the level of evidence (LOE). Results: Nine studies were included for further assessments, of which seven studies stated that metformin was not associated with poor COVID-19 outcomes (LOE II-V), while the other two with poorer designs stated otherwise (LOE V). Although metformin may increase the risk of developing acidosis and lactic acidosis (LOE IV), the observed risks were more accentuated in patients with severe COVID-19 disease or kidney impairment and in patients with > 2 daily metformin doses. Interestingly, one study revealed that metformin may even yield therapeutic role in reducing the risk of COVID-19 mortality (LOE II), although further studies are required to confirm these findings. Conclusions: Our findings indicated that metformin may be safely continued in COVID-19 patients. The benefit of metformin therapy with simultaneous continuous monitoring of COVID-19 severity and kidney function may outweigh the risks of lactic acidosis, of which incidence is relatively rare. © 2021, Research Society for Study of Diabetes in India. |
COVID-19; Metformin; Prognosis; Type 2 diabetes mellitus |
hemoglobin A1c; metformin; acidosis; adult; Article; case report; clinical article; coronavirus disease 2019; diabetic patient; disease course; disease severity; drug safety; estimated glomerular filtration rate; glycemic control; human; kidney failure; kidney function; lactic acidosis; male; middle aged; mortality; mortality risk; non insulin dependent diabetes mellitus; prognosis; systematic review |
Springer |
09733930 |
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Article |
Q3 |
205 |
19024 |
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441 |
Sukmawati D., Junaidi H., Syaidah R. |
55615650900;57202926303;55418885900; |
Human platelet-rich plasma as a biological stimulant for proliferation and differentiation of mesenchymal stem cells |
2021 |
Biomedicine (India) |
41 |
2 |
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168 |
173 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117427828&doi=10.51248%2f.v41i2.777&partnerID=40&md5=08fabc44956a1de6990d42feb38813ba |
Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia |
Sukmawati, D., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Junaidi, H., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Syaidah, R., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia |
Platelet is one of the cells within the blood that have potential in regenerative therapy. Recently platelet-related products got special attention due to the abundance of growth factors and easy availability and processing. With the robust in cell-based therapy, platelet-rich plasma (PRP) has been intensively studied for its potential to substitute the fetal bovine serum (FBS) as the supplement in cell culture. Our study aimed to investigate the use of human PRP in mesenchymal stem cells (MSC) culture and its related effect on stem cell biology. We searched in vitro studies that used human PRP as a supplementing factor on human MSCs culture. From the initial 172 studies, 14 studies fulfilled the selection criteria and were analysed. The results showed that the sources of MSCs were varied, including adipose tissue, bone marrow, and dental tissue. The PRP concentration showing the best effects was ranged from 10 to 20%. In addition, most of the studies demonstrated the superiority of PRP to FBS in promoting the proliferation and differentiation of MSCs in vitro. Therefore, PRP could be an alternative to FBS in supporting a xeno-free culture system. Studies are needed to reveal the mechanism of PRP in maintaining the physiology of MSCs. © 2021, Indian Association of Biomedical Scientists. All rights reserved. |
Cell culture; Differentiation; Mesenchymal stem cells; Platelet-rich plasma; Proliferation; Xeno-free |
adipose tissue; Article; bone marrow; cell differentiation; cell proliferation; controlled study; human; human cell; in vitro study; mesenchymal stem cell; thrombocyte rich plasma; tooth tissue; xeno-free culture |
Indian Association of Biomedical Scientists |
09702067 |
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Article |
Q4 |
106 |
29384 |
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574 |
Khaedir Y., Kartika R. |
57210448725;57216548032; |
Perspectives on Targeting IL-6 as a Potential Therapeutic Strategy for COVID-19 |
2021 |
Journal of Interferon and Cytokine Research |
41 |
2 |
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37 |
43 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101400819&doi=10.1089%2fjir.2020.0135&partnerID=40&md5=98ca5a1b9e49b8a60fe141024cc36031 |
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Immunology, Master's Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Division of Metabolic, Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia |
Khaedir, Y., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia, Immunology, Master's Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Kartika, R., Division of Metabolic, Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia |
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been a major threat to global public health. In Indonesia, the cases have rapidly increased, and the case fatality rate remains high. With COVID-19, most of the deaths have been caused by acute respiratory distress syndrome and dysregulation of the immune response. A lung biopsy from a patient with COVID-19 showed inflammatory cellular infiltration with diffuse alveolar damage. Massive pulmonary destruction has also been reported as a result of highly increased levels of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β, interferon-γ(IFN-γ), induced protein 10 (IP-10), and monocyte chemoattractant protein-1 (MCP-1). IL-6 is an inflammatory cytokine produced by various cell types, including immune cells and nonleukocytes, such as endothelial cells, fibroblasts, epithelial cells, type II pneumocytes, and certain tumor cells. Several studies have shown that IL-6 contributes to the severity and mortality of COVID-19. In this review, we would like to explore the immune response in COVID-19 and the role of IL-6 in the immunopathogenesis of COVID-19. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
coronavirus disease 2019; immune response; interleukin-6 |
interleukin 6; tocilizumab; IL6 protein, human; interleukin 6; interleukin 6 receptor; JAK1 protein, human; JAK2 protein, human; Janus kinase 1; Janus kinase 2; Janus kinase inhibitor; monoclonal antibody; pyrazole derivative; ruxolitinib; sarilumab; tocilizumab; cell infiltration; clinical outcome; coronavirus disease 2019; cytokine storm; human; immune response; immunopathogenesis; lung alveolus cell; priority journal; prospective study; Review; Severe acute respiratory syndrome coronavirus 2; signal transduction; cytokine release syndrome; drug effect; immunology; Indonesia; pathology; respiratory distress syndrome; Antibodies, Monoclonal, Humanized; COVID-19; Cytokine Release Syndrome; Humans; Indonesia; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Janus Kinase Inhibitors; Pyrazoles; |
Mary Ann Liebert Inc. |
10799907 |
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33621130 |
Review |
Q1 |
1031 |
4200 |
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No records
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339 |
Agustina R., Wirawan F., Sadariskar A.A., Setianingsing A.A., Nadiya K., Prafiantini E., Asri E.K., Purwanti T.S., Kusyuniati S., Karyadi E., Raut M.K. |
57214141404;57205313463;57210125132;57226321426;57216508166;57193088368;57190772302;57205062492;57205061970;6603080272;57216503454; |
Associations of Knowledge, Attitude, and Practices toward Anemia with Anemia Prevalence and Height-for-Age Z-Score among Indonesian Adolescent Girls |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
|
S92 |
S108 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111145577&doi=10.1177%2f03795721211011136&partnerID=40&md5=d0a997eb61ed43eeeaf66ad5f9bb416a |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nutrition International Country Office, Jakarta, Indonesia; Former Nutrition International Country Office, Jakarta, Indonesia; Nutrition International, Asia Regional Office, New Delhi, India |
Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wirawan, F., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sadariskar, A.A., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Setianingsing, A.A., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nadiya, K., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Asri, E.K., Nutrition International Country Office, Jakarta, Indonesia; Purwanti, T.S., Nutrition International Country Office, Jakarta, Indonesia; Kusyuniati, S., Nutrition International Country Office, Jakarta, Indonesia; Karyadi, E., Former Nutrition International Country Office, Jakarta, Indonesia; Raut, M.K., Nutrition International, Asia Regional Office, New Delhi, India |
Background: Crucial gaps persist in knowledge, attitude, and practice (KAP) of adolescent girls that affect anemia and linear growth failure. Objective: To understand the role of KAP as a risk factor of anemia and linear growth problem in adolescent girls. Methods: We conducted a cross-sectional survey of 335 adolescent girls selected by clustered random sampling. The KAP questionnaire had 18 variables consisting of 9 knowledge, 3 attitude, and 6 practice components. Twelve variables addressed nutrition, dietary diversity, and health environments related to both anemia and stunting. The questionnaire was adapted from the 2014 Food and Agriculture Organization nutrition-related KAP guidelines for anemia. Dietary practice was evaluated from 2-day 24-hour recalls and a semi-quantitative food-frequency questionnaire. Associations between KAP and anemia, and height-for-age z-score (HAZ), were analyzed using multivariate logistic and linear regression models, respectively. Results: The mean hemoglobin (Hb) level was 119.7 g/L, with 44% of the adolescent girls being anemic (Hb < 120 g/L) and mean height was 151.0 cm with 25% being stunted (HAZ < −2 standard deviation [SD]). The median KAP score was 7 and ranged from 3 to 10. Low to moderate KAP scores were not significantly associated with being anemic (adjusted odds ratio [AOR] = 1.26; P =.43), however 1-point KAP score increment was associated with an increase of HAZ by 0.037 SD (P =.012). Conclusions: The KAP related to diet and healthy environments was not associated with anemia prevalence, but was positively associated with increased HAZ among adolescent girls. Strategy to reduce anemia risk in this population should combine KAP improvement with other known effective nutrition interventions. © The Author(s) 2021. |
adolescent girls; anemia; hemoglobin; knowledge-attitude-practice; linear growth |
adolescence; anemia; attitudinal survey; disease prevalence; hemoglobin; risk factor |
SAGE Publications Inc. |
03795721 |
|
34282657 |
Article |
Q1 |
649 |
7743 |
|
|
340 |
Rah J.H., Melse-Boonstra A., Agustina R., van Zutphen K.G., Kraemer K. |
8298189500;6603151574;57214141404;57200080421;24724460700; |
The Triple Burden of Malnutrition Among Adolescents in Indonesia |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
|
S4 |
S8 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111111554&doi=10.1177%2f03795721211007114&partnerID=40&md5=863a09d51aa051b285f86121637fe0a5 |
UNICEF Indonesia, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands; Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Center (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sight and Life, Basel, Switzerland; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States |
Rah, J.H., UNICEF Indonesia, Jakarta, Indonesia; Melse-Boonstra, A., Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Center (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; van Zutphen, K.G., Division of Human Nutrition and Health, Wageningen University Research, Wageningen, Netherlands, Sight and Life, Basel, Switzerland; Kraemer, K., Sight and Life, Basel, Switzerland, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States |
Background: Indonesia is a prime example of the triple burden of malnutrition. Indonesian adolescents are among the hardest hit, with approximately one in four adolescent girls suffering from anemia, while nearly one in seven adolescents is overweight or obese. Objectives: The present editorial provides a snapshot of the various research papers included in this Supplement, which calls for increased attention to adolescent nutrition in Indonesia and beyond. Results: Despite major steps to reduce undernutrition and overweight, including a renewed focus on anemia among adolescent girls, major gaps remain in our understanding of various nutrition issues concerning adolescents. These include various drivers and determinants of the triple burden of malnutrition, evidence-based interventions that are supported by large-scale implementation research and evaluation, and effective delivery platforms to reach the most vulnerable groups of adolescents. Conclusion: The time has come to position adolescent nutrition as central to development, and mainstream it into health sector plans, strategies, and policies. It is our hope that this issue will stimulate the urgently needed interventions, implementation research and required programs that will safeguard the nutritional wellbeing of today's forgotten generation. © The Author(s) 2021. |
adolescents; anemia; health; Indonesia; nutrition; overweight |
|
SAGE Publications Inc. |
03795721 |
|
34282654 |
Editorial |
Q1 |
649 |
7743 |
|
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342 |
Sparrow R., Agustina R., Bras H., Sheila G., Rieger M., Yumna A., Feskens E., Melse-Boonstra A. |
57205017055;57214141404;6701410272;57226298367;57205307158;55785938100;7005435520;6603151574; |
Adolescent Nutrition—Developing a Research Agenda for the Second Window of Opportunity in Indonesia |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
|
S9 |
S20 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111099959&doi=10.1177%2f0379572120983668&partnerID=40&md5=69aa26692477cd183f7001a03be4e684 |
Development Economics Group, Wageningen University, Netherlands; International Institute of Social Studies, Erasmus University Rotterdam, Netherlands; Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Economic and Social History, University of Groningen, Netherlands; The SMERU Research Institute, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University, Netherlands |
Sparrow, R., Development Economics Group, Wageningen University, Netherlands, International Institute of Social Studies, Erasmus University Rotterdam, Netherlands; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bras, H., Economic and Social History, University of Groningen, Netherlands; Sheila, G., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rieger, M., International Institute of Social Studies, Erasmus University Rotterdam, Netherlands; Yumna, A., The SMERU Research Institute, Jakarta, Indonesia; Feskens, E., Division of Human Nutrition and Health, Wageningen University, Netherlands; Melse-Boonstra, A., Division of Human Nutrition and Health, Wageningen University, Netherlands |
Background: Recently, adolescence has been identified as a second window of opportunity for the correction of nutritional inadequacies. However, there is a lack of knowledge on evidence-based integrated nutrition strategies for adolescents in Indonesia. Objective: To provide a research agenda and the prioritization of research actions to tackle outstanding knowledge gaps on adolescent nutrition in Indonesia. Methods: A preliminary set of research topics was listed based on a desk study of the academic literature and policy documents. Second, a stakeholder meeting was held to further identify and discuss research topics related to adolescent nutrition in Indonesia. Third, an online survey was conducted in which respondents were asked to indicate priority research themes for the next 3 to 5 years and to rank a total of 23 research questions. Results: Most (52%) of the respondents who returned the survey (n = 27) prioritize research on implementation and program evaluation, while 30% prefer descriptive and explanatory research, and 19% place priority with intervention and discovery research. However, when we followed up with specific topics for each of these broad research areas, a more nuanced picture emerged, with intervention and discovery research taking a more prominent standing. Conclusions: In order to support the design, implementation, and effectiveness of integrated nutrition programs for Indonesian adolescents, in-depth studies should question the best intervention strategies, modes of delivery, and long-term outcomes, while nationwide and disaggregated data should investigate associations and trends over time and identify vulnerable groups. © The Author(s) 2021. |
adolescents; Indonesia; nutrition; research agenda |
adolescence; nutrition; prioritization; stakeholder; adolescent; adolescent nutrition; article; clinical article; controlled study; female; human; Indonesia; Indonesian; male; program evaluation; Indonesia |
SAGE Publications Inc. |
03795721 |
|
34282651 |
Article |
Q1 |
649 |
7743 |
|
|
343 |
Agustina R., Meilianawati, Fenny, Atmarita, Suparmi, Susiloretni K.A., Lestari W., Pritasari K., Shankar A.H. |
57214141404;57224214324;57226280026;57191035215;57201388096;55920057100;57222081857;36490128600;7005442634; |
Psychosocial, Eating Behavior, and Lifestyle Factors Influencing Overweight and Obesity in Adolescents |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
|
S72 |
S91 |
|
3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111017301&doi=10.1177%2f0379572121992750&partnerID=40&md5=430a97f5027110c908b0a552342f5ec8 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia; Semarang Health Polytechnic Ministry of Health—Poltekkes Kemenkes Semarang, Indonesia; Directorate of Public Health, Ministry of Health, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom |
Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Meilianawati, Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Fenny, Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Atmarita, National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia; Suparmi, National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia; Susiloretni, K.A., Semarang Health Polytechnic Ministry of Health—Poltekkes Kemenkes Semarang, Indonesia; Lestari, W., Department of Nutrition, Faculty of Medicine, Universitas Indonesia —Dr. Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Pritasari, K., Directorate of Public Health, Ministry of Health, Jakarta, Indonesia; Shankar, A.H., Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom |
Background: Adolescent overweight and obesity (AOO) is a global public health problem and risk for noncommunicable diseases. Understanding context-specific risks is crucial for interventions. Objective: Determine the prevalence of AOO in the Indonesian National Health Survey (INHS) 2013, assess the 5-year trend from 2013 to 2018, and identify risks. Methods: We selected adolescents aged 10 to 19 years (n = 174 290) from the INHS 2013 and used hierarchical logistic regression to identify gender-specific risks for those aged 15 to 19 years (n = 77 534). Change in AOO was assessed by comparison to INHS 2018 reports. Results: The national AOO prevalence increased over 5 years by 48% in young adolescents (13-15 years) and 85% in older ones (16-18 years). High prevalence areas included the urban location of Jakarta (20.9%) and the remote rural region of Papua (19.4%). Overall, AOO risks were being sedentary, male, lower education, married, younger adolescent, and school enrollment, with urban residence and higher wealth being persistent risks for all analyses. Data for depressive symptoms were available for older adolescents whose additional risks were being sedentary, depressive symptoms, and high-fat diet. Male risks were being sedentary and lower education, and female risks were being married, depressive symptoms, high-fat intake, and lower education. Higher intake of fruits and vegetables and fewer sweets did not protect against AOO if a high-fat diet was consumed. Conclusions: Adolescent overweight and obesity in Indonesia is rapidly increasing, especially in older adolescents and males, and with gender-specific risks. Customized multisectoral interventions to identify strategies for lifestyle change are urgently needed. © The Author(s) 2021. |
adolescents; depressive symptoms; nutrition; obesity; overweight |
adolescence; behavioral ecology; disease prevalence; factor analysis; health risk; lifestyle; noncommunicable disease; obesity; psychology; public health; Indonesia; Jakarta; Papua [(PRV) Indonesia] |
SAGE Publications Inc. |
03795721 |
|
34282658 |
Article |
Q1 |
649 |
7743 |
|
|
485 |
Simadibrata D.M., Calvin J., Wijaya A.D., Ibrahim N.A.A. |
57202134322;57221411392;57221411463;57221410260; |
Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis |
2021 |
American Journal of Emergency Medicine |
42 |
|
|
60 |
69 |
|
22 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099401846&doi=10.1016%2fj.ajem.2021.01.006&partnerID=40&md5=9764e041c3a47b836e3ffc766efdf406 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Simadibrata, D.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Calvin, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wijaya, A.D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ibrahim, N.A.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The neutrophil-to-lymphocyte ratio (NLR), an inflammatory marker, was suggested to be predictive of severity and mortality in COVID-19 patients. Here, we investigated whether NLR levels on admission could predict the severity and mortality of COVID-19 patients. Methods: A literature search was conducted on 23 July 2020 to retrieve all published articles, including grey literature and preprints, investigating the association between on-admission NLR values and severity or mortality in COVID-19 patients. A meta-analysis was performed to determine the overall standardized mean difference (SMD) in NLR values and the pooled risk ratio (RR) for severity and mortality with the 95% Confidence Interval (95%CI). Results: A total of 38 articles, including 5699 patients with severity outcomes and 6033 patients with mortality outcomes, were included. The meta-analysis showed that severe and non-survivors of COVID-19 had higher on-admission NLR levels than non-severe and survivors (SMD 0.88; 95%CI 0.72–1.04; I2 = 75.52% and 1.87; 95%CI 1.25–2.49; I2 = 97.81%, respectively). Regardless of the different NLR cut-off values, the pooled mortality RR in patients with elevated vs. normal NLR levels was 2.74 (95%CI 0.98–7.66). Conclusion: High NLR levels on admission were associated with severe COVID-19 and mortality. Further studies need to focus on determining the optimal cut-off value for NLR before clinical use. © 2021 Elsevier Inc. |
COVID-19; Meta-analysis; Mortality; Neutrophil-to-lymphocyte ratio; Severity |
Article; coronavirus disease 2019; disease association; disease severity; hospital admission; human; meta analysis; mortality; mortality risk; neutrophil lymphocyte ratio; outcome assessment; prediction; priority journal; quality control; risk assessment; sensitivity and specificity; sex ratio; survivor; systematic review; blood; diagnosis; hospitalization; lymphocyte count; neutrophil; severity of illness index; survival rate; COVID-19; Hospitalization; Humans; Lymphocyte Count; Neutrophils; Severity of Illness Index; Survival Rate |
W.B. Saunders |
07356757 |
|
33453617 |
Article |
Q1 |
725 |
6828 |
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489 |
Pranata R., Tondas A.E., Huang I., Lim M.A., Siswanto B.B., Meyer M., Mitrovic V. |
57201973901;57211111907;57208576645;57216039756;14422648800;57217373886;36008843300; |
Potential role of telemedicine in solving ST-segment elevation dilemmas in remote areas during the COVID-19 pandemic |
2021 |
American Journal of Emergency Medicine |
42 |
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242 |
243 |
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10 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086651966&doi=10.1016%2fj.ajem.2020.06.012&partnerID=40&md5=c3d261a0e2fe3a8f2757142babbe0759 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia; Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas, Jakarta, Indonesia; Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Tondas, A.E., Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia, Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Meyer, M., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas, Jakarta, Indonesia; Mitrovic, V., Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany |
[No abstract available] |
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troponin; acute coronary syndrome; blood clot lysis; cardiologist; cardiovascular risk; coronavirus disease 2019; echocardiography; electrocardiography; heart ventricle wall motion; human; incidence; Letter; myocarditis; pandemic; practice guideline; priority journal; risk factor; ST segment elevation; ST segment elevation myocardial infarction; takotsubo cardiomyopathy; telecardiology; telemedicine; epidemiology; health care delivery; organization and management; prevention and control; rural health care; ST segment elevation myocardial infarction; telemedicine; COVID-19; Health Services Accessibility; Humans; Rural Health Services; ST Elevation Myocardial Infarction; Telemedicine |
W.B. Saunders |
07356757 |
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32561139 |
Letter |
Q1 |
725 |
6828 |
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560 |
Purbadi S., Saspriyana K.Y. |
6505677307;57215693910; |
Primary debulking surgery of advanced epithelial ovarian cancer in developing countries: Challenges and expectations |
2021 |
European Journal of Gynaecological Oncology |
42 |
1 |
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26 |
29 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101075370&doi=10.31083%2fj.ejgo.2021.01.2230&partnerID=40&md5=7e3562ded7816ae8267f39ec3c207282 |
Gynaecology Oncology Division, Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, 10430, Indonesia; Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Obstetric and Gynecology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, 80113, Indonesia |
Purbadi, S., Gynaecology Oncology Division, Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, 10430, Indonesia; Saspriyana, K.Y., Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Obstetric and Gynecology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, 80113, Indonesia |
Ovarian cancer often presents itself in advanced stages and can be accompanied by various comorbidities. Treatment options are primary debulking surgery (PDS) followed by adjuvant chemotherapy, or alternatively, neoadjuvant chemotherapy followed by interval debulking surgery (IDS). The option taken is based on several considerations. If the patient can be treated with PDS, the absence of macroscopic residual disease becomes an independent prognostic factor. However, achieving this outcome is a challenge for the gynaecologic oncologist since advanced stage ovarian cancer generally metastasizes into the peritoneum and the upper abdominal organs. Optimal outcomes are that surgery will be safe for the patient, no macroscopic residual disease is achieved, minimal postoperative complications are encountered, and a good survival rate is obtained. Developed countries, especially Europe, have well-recognized standards of care which are followed by developing countries; however, challenges with insurance coverage and inter-departmental cooperation are recognized hurdles in developing countries. Competency improvement along with good inter-departmental communication and collaboration are keys to optimal outcomes for PDS. © 2021 The Authors. Published by IMR Press. |
Competency; Interdepartmental approach; Ovarian cancer; Primary debulking surgery; Residual disease |
abdominal viscera; cancer prognosis; cancer staging; cytoreductive surgery; developing country; Europe; European; female; health insurance; human; intersectoral collaboration; learning; medical society; minimal residual disease; outcome assessment; ovary carcinoma; peritoneum metastasis; postoperative complication; public-private partnership; Review; survival rate |
IMR Press Limited |
03922936 |
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Review |
Q4 |
150 |
23157 |
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