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248 |
Goh K.-L., Lee Y.-Y., Leelakusolvong S., Makmun D., Maneerattanaporn M., Quach D.T., Raja Ali R.A., Sollano J.D., Tran V.H., Wong R.K.-M. |
7201860992;56191149300;6602285199;16638046900;16638087300;37099075800;40762153700;6602099153;56448091600;57226554480; |
Consensus statements and recommendations on the management of mild-to-moderate gastroesophageal reflux disease in the Southeast Asian region |
2021 |
JGH Open |
5 |
8 |
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855 |
863 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111938998&doi=10.1002%2fjgh3.12602&partnerID=40&md5=4a62cd64a09fae57e0e5ba1fbcccc112 |
Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia; Division of Gastroenterology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Gastroenterology Unit, Department of Medicine and Gut Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bangi, Malaysia; Department of Gastroenterology, University of Santo Tomas, Manila, Philippines; Department of Gastroenterology, Hue University of Medicine and Pharmacy, Hue University, Hue City, Viet Nam; Department of Medicine, Faculty of Medicine, National University of Singapore, Singapore |
Goh, K.-L., Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Lee, Y.-Y., Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia; Leelakusolvong, S., Division of Gastroenterology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Makmun, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Maneerattanaporn, M., Division of Gastroenterology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Quach, D.T., Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Raja Ali, R.A., Gastroenterology Unit, Department of Medicine and Gut Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bangi, Malaysia; Sollano, J.D., Department of Gastroenterology, University of Santo Tomas, Manila, Philippines; Tran, V.H., Department of Gastroenterology, Hue University of Medicine and Pharmacy, Hue University, Hue City, Viet Nam; Wong, R.K.-M., Department of Medicine, Faculty of Medicine, National University of Singapore, Singapore |
This paper reports the proceedings from the first consensus meeting on the management of mild-to-moderate gastroesophageal reflux disease (GERD) in the Southeast Asian (SEA) region. Seventeen statements were drawn up by a steering committee that focused on epidemiology, mechanism of action, diagnostic investigations, and treatment. Voting on the recommendations used the Delphi method with two rounds of voting among the 10 panel members. The consensus panel agreed that GERD is mostly a mild disease in the SEA region with predominantly non-erosive reflux disease (NERD). Complicated GERD and Barrett's esophagus are infrequently seen. The panel recommended endoscopy in patients with alarm or refractory symptoms but cautioned that the incidence of gastric cancer is higher in SEA. pH and impedance measurements were not recommended for routine assessment. The acid pocket is recognized as an important pathogenic factor in GERD. Lifestyle measures such as weight reduction, avoidance of smoking, reduction of alcohol intake, and elevation of the head of the bed were recommended but strict avoidance of specific foods or drinks was not. Alginates was recommended as the first-line treatment for patients with mild-to-moderate GERD while recognizing that proton-pump inhibitors (PPIs) remained the mainstay of treatment of GERD. The use of alginates was also recommended as adjunctive therapy when GERD symptoms were only partially responsive to PPIs. © 2021 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
alginates; consensus recommendations; mild-to-moderate gastroesophageal reflux disease; proton-pump inhibitors |
alginic acid; antacid agent; proton pump inhibitor; alcohol consumption; Article; Barrett esophagus; body mass; body weight loss; consensus development; Delphi study; dysphagia; endoscopy; esophagitis; evidence based practice; gastroesophageal reflux; gastroscopy; Helicobacter pylori; hiatus hernia; human; intestine metaplasia; lower esophagus sphincter; metaplasia; non erosive reflux disease; population research; prevalence; quality of life; questionnaire; smoking reduction; Southeast Asia; strategic reserve |
John Wiley and Sons Inc |
23979070 |
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Article |
Q3 |
546 |
9258 |
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256 |
Farani M., Saldi S.R.F., Maulahela H., Abdullah M., Syam A.F., Makmum D. |
57226146409;55201904000;57189612709;7103393434;8443384400;57226163778; |
Survival, stent patency, and cost-effectiveness of plastic biliary stent versus metal biliary stent for palliation in malignant biliary obstruction in a developing country tertiary hospital |
2021 |
JGH Open |
5 |
8 |
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959 |
965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110682374&doi=10.1002%2fjgh3.12618&partnerID=40&md5=af5645f91acde4bbed01da739a4f2b1f |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Farani, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Saldi, S.R.F., Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Abdullah, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Makmum, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background and Aim: Patients with advanced malignant obstructive jaundice often require biliary drainage. Resources restraint makes clinicians need to outweigh effectiveness of each biliary stents and their costs. Hence, a cost-effectiveness analysis is necessary. Methods: A retrospective cohort study was done on malignant biliary obstruction patients undergoing palliative biliary stenting between January 2015 and December 2018. We evaluated 180-day survival rate using log-rank test and stent patency duration using Mann–Whitney U test. Effectiveness was defined as stent patency, while cost was calculated using hospital perspective using decision tree model and reported as incremental cost-effectiveness ratio. Results: A total of 81 men and 83 women were enrolled in this study. One hundred and eighty days survival rate was 35.9% (median 76 days, 95% confidence interval [CI] 50–102 days) and 33.3% (median 55 days, 95% CI 32–78 days), while average stent patency was 123 (8) days versus 149 (13) days for plastic and metal stent groups, respectively (P > 0.05). Metal stent could save Indonesian Rupiah (IDR) 1 217 750 to get additional 26 days of patency. Conclusion: There were no differences in survival and stent patency between the two groups. Metal biliary stent is more cost-effective than plastic stent for palliation in malignant biliary obstruction. © 2021 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
biliary stent; cost-effectiveness; malignant biliary obstruction |
bilirubin; Article; brain ischemia; cohort analysis; controlled study; cost effectiveness analysis; developing country; endoscopic retrograde cholangiopancreatography; hemodialysis; human; jaundice; liver cirrhosis; log rank test; major clinical study; mortality rate; observational study; overall survival; percutaneous coronary intervention; rank sum test; retrospective study; survival rate |
John Wiley and Sons Inc |
23979070 |
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Article |
Q3 |
546 |
9258 |
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295 |
Sugiharto P., Ramlan A.A.W. |
57286412100;57195941841; |
Effectiveness of mindfulness-based intervention technique in reducing stress levels of anesthesiology and intensive therapy residents |
2021 |
Bali Journal of Anesthesiology |
5 |
3 |
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166 |
170 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116416960&doi=10.4103%2fbjoa.bjoa_251_20&partnerID=40&md5=ec537b920b0bac4177ea8de114c87660 |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Sugiharto, P., Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: An anesthesiologist is expected to be able to manage intraoperative crises that can occur at any time. We aimed to determine the effectiveness of mindfulness-based intervention (MBI) technique in reducing stress levels of anesthesiology and intensive therapy residents at the Faculty of Medicine, University of Indonesia. Materials and Methods: This research was an experimental study with paired one group design. The MBI program lasted 4 weeks, consisted of one formal face-to-face training and 4 weeks of informal training (homework). Thirteen study subjects met the inclusion criteria and did not enter the exclusion criteria. One study subject was excluded because the subject did not complete the informal training. Data collection on the Perceived Stress Scale 10-Item (PSS-10) was conducted before and after training. Results: The average age of study subjects was 29.75 years; 75% are women. Four participants were in the 1 st year of education (33%), 3 participants were in the 2 nd year of education (25%), 2 participants were in the 3 rd year of education (16.67%), and 3 participants were in the 4 th year of education (25%). PSS-10 score in the study subjects significantly decreased after applying the MBI technique for 4 weeks (P = 0.001). Conclusion: MBI is effective in reducing stress levels of anesthesiology and intensive therapy residents at the-blinded. © 2020 Bali Journal of Anesthesiology | Published by Wolters Kluwer-Medknow. |
Anesthesiologist; mindfulness; resident; stress |
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Wolters Kluwer Medknow Publications |
25492276 |
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Article |
#N/A |
#N/A |
#N/A |
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421 |
Teixeira J.C., Jacobs G.S., Stringer C., Tuke J., Hudjashov G., Purnomo G.A., Sudoyo H., Cox M.P., Tobler R., Turney C.S.M., Cooper A., Helgen K.M. |
56290678400;56504646300;7005875885;20435156700;8937651700;56262110300;6603548824;8699959500;55780763900;7003984281;57225849511;6602538000; |
Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture |
2021 |
Nature Ecology and Evolution |
5 |
5 |
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616 |
624 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102829045&doi=10.1038%2fs41559-021-01408-0&partnerID=40&md5=0f530b00ed05b700fb2df18763c0144f |
Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Complexity Institute, Nanyang Technological University, Singapore, Singapore; Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; South Australian Museum, Adelaide, SA, Australia; BlueSky Genetics, Ashton, SA, Australia; Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
Teixeira, J.C., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Jacobs, G.S., Complexity Institute, Nanyang Technological University, Singapore, Singapore, Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Stringer, C., Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; Tuke, J., School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Hudjashov, G., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Purnomo, G.A., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sudoyo, H., Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Cox, M.P., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Tobler, R., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Turney, C.S.M., Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; Cooper, A., South Australian Museum, Adelaide, SA, Australia, BlueSky Genetics, Ashton, SA, Australia; Helgen, K.M., ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia, Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
The hominin fossil record of Island Southeast Asia (ISEA) indicates that at least two endemic ‘super-archaic’ species—Homo luzonensis and H. floresiensis—were present around the time anatomically modern humans arrived in the region >50,000 years ago. Intriguingly, contemporary human populations across ISEA carry distinct genomic traces of ancient interbreeding events with Denisovans—a separate hominin lineage that currently lacks a fossil record in ISEA. To query this apparent disparity between fossil and genetic evidence, we performed a comprehensive search for super-archaic introgression in >400 modern human genomes, including >200 from ISEA. Our results corroborate widespread Denisovan ancestry in ISEA populations, but fail to detect any substantial super-archaic admixture signals compatible with the endemic fossil record of ISEA. We discuss the implications of our findings for the understanding of hominin history in ISEA, including future research directions that might help to unlock more details about the prehistory of the enigmatic Denisovans. © 2021, The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature. |
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animal; fossil; genetics; hominid; Homo neanderthalensis; human; island (geological); Southeast Asia; Animals; Asia, Southeastern; Fossils; Hominidae; Humans; Islands; Neanderthals |
Nature Research |
2397334X |
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33753899 |
Article |
Q1 |
5822 |
225 |
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592 |
Pribadi R.R., Simadibrata M. |
57194732282;23499598400; |
Increased serum amylase and/or lipase in coronavirus disease 2019 (COVID-19) patients: Is it really pancreatic injury? |
2021 |
JGH Open |
5 |
2 |
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190 |
192 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098140408&doi=10.1002%2fjgh3.12436&partnerID=40&md5=14da866c743f8e6c2bdfff73d45cc7a5 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Pribadi, R.R., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Simadibrata, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Coronavirus disease 2019 (COVID-19) is a novel disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although it mainly affects the respiratory system, the pancreas could also become the virus' target. The issue regarding pancreatic involvement in COVID-19 has been raised by several researchers. They found increased serum amylase and/or lipase in COVID-19 patients, which suggested pancreatic injury. We aimed to critically review the evidence to provide insights and to answer the very question of the possibility of pancreatic injury. Current evidence shows that increased amylase and/or lipase is not necessarily a pancreatic injury in COVID-19 patients. Those increased enzymes might also be found in other clinical conditions. © 2020 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
amylases; COVID-19; lipase; pancreas |
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John Wiley and Sons Inc |
23979070 |
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Review |
Q3 |
546 |
9258 |
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601 |
Siswanto J.E., Bos A.F., Dijk P.H., Rohsiswatmo R., Irawan G., Sulistijono E., Sianturi P., Wisnumurti D.A., Wilar R., Sauer P.J.J. |
57205060577;36839156800;6701798049;55533574600;57221815645;57218101844;57192896614;57200574807;57201130415;57221818237; |
Multicentre survey of retinopathy of prematurity in Indonesia |
2021 |
BMJ Paediatrics Open |
5 |
1 |
e000761 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100318807&doi=10.1136%2fbmjpo-2020-000761&partnerID=40&md5=0c40a01ee7a27d4289754e988161b732 |
Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands; Neonatology, Harapan Kita National Centre for Women and Children's Health, Jakarta, Indonesia; Neonatology, University Medical Center Groningen Intensive Care Medicine, Groningen, Netherlands; Pediatric, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Pediatric, Dr Kariadi General Hospital Medical Center, Semarang, Central Java, Indonesia; Pediatric, Dr Saiful Anwar General Hospital, Malang, Jawa Timur, Indonesia; Pediatric, University of Sumatera Utara Faculty of Medicine, Medan, North Sumatera, Indonesia; Pediatric, University of Riau Faculty of Medicine, Pekanbaru, Riau, Indonesia; Pediatric, Sam Ratulangi University Faculty of Medicine, Manado, North Sulawesi, Indonesia |
Siswanto, J.E., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands, Neonatology, Harapan Kita National Centre for Women and Children's Health, Jakarta, Indonesia; Bos, A.F., Neonatology, University Medical Center Groningen Intensive Care Medicine, Groningen, Netherlands; Dijk, P.H., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands; Rohsiswatmo, R., Pediatric, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Irawan, G., Pediatric, Dr Kariadi General Hospital Medical Center, Semarang, Central Java, Indonesia; Sulistijono, E., Pediatric, Dr Saiful Anwar General Hospital, Malang, Jawa Timur, Indonesia; Sianturi, P., Pediatric, University of Sumatera Utara Faculty of Medicine, Medan, North Sumatera, Indonesia; Wisnumurti, D.A., Pediatric, University of Riau Faculty of Medicine, Pekanbaru, Riau, Indonesia; Wilar, R., Pediatric, Sam Ratulangi University Faculty of Medicine, Manado, North Sulawesi, Indonesia; Sauer, P.J.J., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands |
Background: The incidence of retinopathy of prematurity (ROP) is higher in Indonesia than in high-income countries. In order to reduce the incidence of the disease, a protocol on preventing, screening and treating ROP was published in Indonesia in 2010. To assist the practical implementation of the protocol, meetings were held in all Indonesia regions, calling attention to the high incidence of ROP and the methods to reduce it. In addition, national health insurance was introduced in 2014, making ROP screening and treatment accessible to more infants. Objective To evaluate whether the introduction of both the guideline drawing attention to the high incidence of ROP and national health insurance may have influenced the incidence of the disease in Indonesia. Setting Data were collected from 34 hospitals with different levels of care: national referral centres, university-based hospitals, and public and private hospitals. Methods: A survey was administered with questions on admission numbers, mortality rates, ROP incidence, and its stages for 2016-2017 in relation to gestational age and birth weight. Results: We identified 12 115 eligible infants with a gestational age of less than 34 weeks. Mortality was 24% and any stage ROP 6.7%. The mortality in infants aged less than 28 weeks was 67%, the incidence of all-stage ROP 18% and severe ROP 4%. In the group aged 28-32 weeks, the mortality was 24%, all-stage ROP 7% and severe ROP 4%-5%. Both mortality and the incidence of ROP were highest in university-based hospitals. Conclusions: In the 2016-2017 period, the infant mortality rate before 32 weeks of age was higher in Indonesia than in high-income countries, but the incidence of ROP was comparable. This incidence is likely an underestimation due to the high mortality rate. The ROP incidence in 2016-2017 is lower than in surveys conducted before 2015. This decline is likely due to a higher practitioner awareness about ROP and national health insurance implementation in Indonesia. © Author(s) (or their employer(s)) 2021. |
epidemiology; health services research; mortality; neonatology; ophthalmology |
birth weight; controlled study; data collection method; disease severity; female; gestational age; health services research; health survey; high income country; human; incidence; Indonesia; infant; infant mortality; major clinical study; male; mortality rate; multicenter study; national health insurance; patient referral; physician; practice guideline; prematurity; priority journal; private hospital; public hospital; retrolental fibroplasia; Review; teaching hospital; university hospital |
BMJ Publishing Group |
23999772 |
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Review |
Q1 |
821 |
5832 |
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880 |
Putri T.P., Dewi I.A.T.K., Permata T.B.M., Nuryadi E., Kodrat H., Wibowo H., Louisa M., Gondhowiardjo S.A. |
57221919322;57221917792;57197808751;57197806814;57210639849;57217690943;41461551400;6508327402; |
A mini systematic review: Eucheuma cottonii, a red algae, as a radiosensitizer? |
2021 |
Tropical Journal of Natural Product Research |
5 |
1 |
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7 |
15 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100549316&doi=10.26538%2ftjnpr%2fv5i1.2&partnerID=40&md5=0849f73cb51c327672dca7dbaca3460f |
Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Diagnostic and Research Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Putri, T.P., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dewi, I.A.T.K., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wibowo, H., Diagnostic and Research Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutic, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Radiosensitizers assist radiotherapy in providing greater tumor inactivation. Currently there is a search for natural radiosensitizer components which are expected to provide lesser side effects than chemical radiosensitizers. Eucheuma cottonii is a plant with antioxidant and anti-tumor effects. This review aims to search for the potential use of Eucheuma cottonii as a radiosensitizer. This is a mixed review study, where the main component is a systematic review and then followed by a narrative review. This review suggests that Eucheuma cottonii has the potential to become a radiosensitizer, by interfering with the cell cycle control mechanisms and reactivation of p53. Further research is needed to explore the synergistic effect of the combined use of radiotherapy and Eucheuma cottonii. © 2021 Putri et al. |
Anti-tumour; Eucheuma cottonii; Immunomodulator; Radiosensitizer |
antineoplastic agent; birc5 protein; carrageenan; CD4 antigen; CD8 antigen; checkpoint kinase 1; cyclin dependent kinase inhibitor; Eucheuma cottonii extract; gamma interferon; immunomodulating agent; interleukin 4; mouse double minute 2 homolog; plant extract; programmed death 1 ligand 1; protein bcl 2; protein p21; protein p53; radiosensitizing agent; survivin; unclassified drug; antiapoptotic activity; antineoplastic activity; antioxidant activity; antiproliferative activity; apoptosis; cancer cell line; cell cycle regulation; cytotoxicity; gene expression; human; IC50; in vitro study; in vivo study; Kappaphycus alvarezii; MTT assay; neoplasm; nonhuman; phagocytosis; protein expression; radiosensitization; randomized controlled trial (topic); Review; synergistic effect; systematic revie |
Faculty of Pharmacy, University of Benin |
26160684 |
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Review |
Q4 |
127 |
25832 |
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No records
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123 |
Hapsari P.W., Februhartanty J., Bardosono S. |
57211782261;54962283200;21933841000; |
Students’ interests and learning venues as enablers for school-based nutrition education among adolescents in Jakarta |
2021 |
Nutrition and Food Science |
51 |
8 |
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1245 |
1257 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107899113&doi=10.1108%2fNFS-12-2020-0475&partnerID=40&md5=b45b1711d6c37301cd7a37b8fbd2c4c5 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON)/Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Department of Nutrition Science, Universitas Jenderal Soedirman, Jakarta, Purwokerto, Indonesia |
Hapsari, P.W., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Department of Nutrition Science, Universitas Jenderal Soedirman, Jakarta, Purwokerto, Indonesia; Februhartanty, J., Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON)/Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Purpose: This study aims to explore potential enablers for school-based nutrition education (SBNE) through adolescent students’ perceptions in Jakarta, Indonesia. Design/methodology/approach: The study conducted 15 focus group discussions (FGDs) with 6–8 students per group to gather the main data, supported by six in-depth interviews with junior high school officials and content analysis of selected schoolbooks among five schools. The FGDs were conducted to explore students’ interest in nutrition information and their exposure to nutrition education and learning experiences. To analyze the FGD responses, three steps were used: coding, categorizing and determining themes. Findings: Students’ interest in nutrition and potential learning venues for interactive nutrition education were potential enablers for SBNE. The students’ interest in nutrition information comprised eight topics, with some different patterns by gender. Nutrition information not represented in the school books included: food fads, women’s nutrition, halal-certified food establishments and cooking. To complement the nutrition information that was not provided in school books, student club activities and school special programs were suitable settings as potential learning venues for SBNE. Originality/value: This study is the first study exploring SBNE facilitators from students’ perspectives among adolescents in Jakarta. © 2021, Emerald Publishing Limited. |
Adolescents; Indonesia; Nutrition education |
adolescent; article; clinical article; content analysis; cooking; female; food fads; gender; human; human experiment; Indonesia; interview; learning; male; middle school; nutrition education; perception |
Emerald Group Holdings Ltd. |
00346659 |
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Article |
Q3 |
318 |
14272 |
|
|
341 |
Rustamadji P., Wiyarta E., Bethania K.A., Kusmardi K. |
55321572200;57221521342;57226320454;56966625300; |
Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type |
2021 |
Journal of Pathology and Translational Medicine |
51 |
3 |
|
271 |
278 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111106383&doi=10.4132%2fjptm.2021.04.26&partnerID=40&md5=25c257f935b27c34728f8cc05fdeca15 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST. Methods: Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Age, tumor grade, tumor size, lymphovascular invasion (LVI), and AKT expression were assessed. AKT2 expression was assessed based on immunohistochemical staining, while other data were collected from archives. Results: Multiple logistic regression results showed that AKT2 expression and LVI were significantly associated with LNM (odds ratio [OR], 5.32; 95% confidence interval [CI], 1.42 to 19.93 and OR, 4.46; 95% CI, 1.17 to 16.97, respectively). AKT2 expression was able to discriminate against LNM (area under the receiver operating characteristic, 0.799 ± 0.063; 95% CI, 0.676 to 0.921) at an H-score cutoff of 104.62 (83.3% sensitivity, 62.5% specificity). Conclusions: AKT2 expression has potential as a predictor of LNM in IBC-NST. The H-score cutoff for AKT2 expression can be used as a classification guide in future studies. © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology. |
AKT2; Breast neoplasms; Immunohistochemistry; Metastasis |
biological marker; protein kinase B beta; adult; aged; Article; breast carcinoma; cancer grading; clinical article; confidence interval; controlled study; female; human; human tissue; immunohistochemistry; lymph vessel metastasis; multivariate logistic regression analysis; odds ratio; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; tumor invasion; tumor volume |
Seoul National University |
23837837 |
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Article |
Q2 |
684 |
7312 |
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