No records
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128 |
Fadrian F., Chen K., Kumalawati J., Rumende C.M., Shatri H., Nelwan E.J. |
57268114000;57428620500;6504406695;14325966300;28767986500;14527452900; |
The Validation of Drug Resistance in Pneumonia (DRIP) Score in Predicting Infections due to Drug-Resistant Pathogens in Community-acquired Pneumonia at Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
2021 |
Acta medica Indonesiana |
53 |
4 |
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416 |
422 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123567110&partnerID=40&md5=9488cfa84614808f64df6510f7925f6d |
1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Division of Tropical Medicine and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, alas University - M. Djamil Hospital, Padang, Jakarta, Indonesia |
Fadrian, F., 1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Division of Tropical Medicine and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, alas University - M. Djamil Hospital, Padang, Jakarta, Indonesia; Chen, K.; Kumalawati, J.; Rumende, C.M.; Shatri, H.; Nelwan, E.J. |
BACKGROUND: The emergence of drug-resistant pathogens (DRP) in recent years possibly contributes to the common problems associated with community-acquired pneumonia. However, to predict the risk of the ailment, the DRIP score is mainly applied, although no validation study has been reported in Indonesia. Therefore, the score prediction accuracy in the population, patient characteristics and germ patterns appears indefinite, particularly for Cipto Mangunkusumo Hospital, Jakarta. The purpose of this study is to determine the DRIP performance as an instrument in predicting infections due to drug-resistant pathogens (DRP) in community-acquired pneumonia at Cipto Mangunkusumo Hospital. METHODS: This research employed a cross-sectional design, where the subjects were community-acquired pneumonia patients treated between January 2019 and June 2020. In addition, adequate medical records of the participants were obtained. The condition is defined as DRP when the sputum culture results show resistance to non-pseudomonal β-lactam antibiotics, macrolides, and respiratory fluoroquinolones. Furthermore, the score performance was analyzed by determining the calibration and discrimination values, using the Hosmer-Lemeshow test and AUROC, respectively. RESULTS: A total of 254 subjects were known to have satisfied the selection criteria. These participants were categorized into DRP and non-DRP groups, with 103 (40.6%) and 151 (59.4%) patients, correspondingly. The DRIP calibration analysis using the Hosmer-Lemeshow test obtained p-value = 0.001 (p <0.05), while an AUC value of 0.759 (CI 95%, 0.702-0.810) was derived from the ROC curve. However, at a score of ≥ 4, the DRIP showed sensitivity, specificity, positive and negative predictive values of 70.9, 92.7, 86.9, and 82.3%, respectively. CONCLUSION: The DRIP score demonstrated a significant performance in predicting infections due to DRP in community-acquired pneumonia. |
community-acquired pneumonia; DRIP score; resistant pathogens |
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NLM (Medline) |
01259326 |
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35027488 |
Article |
Q3 |
321 |
14162 |
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129 |
Nelwan E.J., Guterres H., Pasaribu A.I., Shakinah S., Limato R., Widodo D. |
14527452900;57223285438;57428543800;57428569400;57196224631;8231822900; |
The Comparison of Point Prevalence Survey (PPS) and Gyssens Flowchart Approach on Antimicrobial Use Surveillance in Indonesian National Referral Hospital |
2021 |
Acta medica Indonesiana |
53 |
4 |
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505 |
511 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123566730&partnerID=40&md5=0eb0821dbbca8a19666af97b0fdd062d |
1. Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia 2. Infection and Immunology Research Cluster, Indonesian Medical Research Institute Faculty of Medicine Universitas Indonesia, Indonesia 3. Member of Antimicrobial Resistance Control Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nelwan, E.J., 1. Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia 2. Infection and Immunology Research Cluster, Indonesian Medical Research Institute Faculty of Medicine Universitas Indonesia, Indonesia 3. Member of Antimicrobial Resistance Control Cipto Mangunkusumo HospitalJakarta, Indonesia; Guterres, H.; Pasaribu, A.I.; Shakinah, S.; Limato, R.; Widodo, D. |
The antimicrobial resistance (AMR) rate in Indonesia is steadily rising, despite the existing national action plan in 2014. In line with the Global Action Plan on AMR, proper surveillance on antimicrobial usage and resistance are needed. At present, antimicrobial surveillance (AMS) data in Indonesia is heterogeneous, fragmented, and localized. The common method of antimicrobial surveillance (AMS) in referral hospitals is by implementing Gyssens flowchart during Antimicrobial Resistance Control Program Committee clinical rounds. However, the recent method of AMS with Point Prevalence Survey (PPS) offers many advantages include its concise and simple protocol, large data collection, shorter required time, comprehensive data outcomes, real-time data, and standardized parameters. In low-middle income countries such as Indonesia with its restricted resources in AMS, PPS is superior compared to the 'traditional' hospital clinical round in generating representative and homogenous outcomes that can be compared to data from other centers worldwide. |
antimicrobial; Gyssens Flowchart; Indonesia; Point Prevalence Survey |
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NLM (Medline) |
01259326 |
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35027501 |
Article |
Q3 |
321 |
14162 |
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130 |
Yulianti M., Johan C., Singh G., Tenda E.D., Herikurniawan H., Wijaya I.P.E.K. |
57216405885;57428554200;57209127773;57189692101;57428567200;57221504958; |
Effectiveness of Convalescent Plasma Therapy in Treating COVID-19: an Evidence-based Case Report |
2021 |
Acta medica Indonesiana |
53 |
4 |
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497 |
504 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123566521&partnerID=40&md5=3ff22c5c237f932569b8171a1ff5221b |
Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Yulianti, M., Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Johan, C.; Singh, G.; Tenda, E.D.; Herikurniawan, H.; Wijaya, I.P.E.K. |
BACKGROUND: Convalescent plasma is a potentially beneficial, tolerable, and available additional treatment option for COVID-19. This study aims to evaluate whether the administration of convalescent plasma therapy leads to improved clinical outcomes in COVID-19 patients compared to standard medical therapy. METHODS: We conducted a search of Pubmed, Cochrane, and EBSCO for studies assessing the clinical question using inclusion and exclusion criteria. Selected studies were critically appraised, and the results were summarized. RESULTS: A meta-analysis of 10 randomized clinical trials (RCTs), an RCT, a case-control clinical study were selected and assessed. Only the case-control clinical study showed that convalescent plasma administration improved the clinical outcomes of patients with COVID-19, including all-cause mortality, hospital length of stay, and the need for mechanical ventilation. On the contrary, the other two studies of a higher level of evidence showed no significant clinical outcome improvement with convalescent plasma therapy. CONCLUSION: The effectiveness of convalescent plasma therapy in improving clinical outcomes of patients with COVID-19 was still inconclusive due to several study limitations and other possible causes. |
convalescent plasma; coronavirus; COVID-19; SARS-CoV-2 |
artificial ventilation; human; meta analysis; passive immunization; randomized controlled trial (topic); therapy; treatment outcome; COVID-19; Humans; Immunization, Passive; Randomized Controlled Trials as Topic; Respiration, Artificial; SARS-CoV-2; Treatment Outcome |
NLM (Medline) |
01259326 |
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35027500 |
Article |
Q3 |
321 |
14162 |
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131 |
Maulahela H., Fauzi A. |
57189612709;36518523000; |
Peripancreatic Tuberculosis Lymphadenopathy: The Role of Endoscopic Ultrasound for Diagnosis |
2021 |
Acta medica Indonesiana |
53 |
4 |
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457 |
459 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123566183&partnerID=40&md5=db2cd4e2d6a90740d0bc3e39263c3c1d |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Fauzi, A. |
Pancreatic and peripancreatic tuberculosis is a rare abdominal tuberculosis. Diagnosis for pancreatic tuberculosis can be challenging. Conventional imaging tools may show mass or malignancy in the pancreas. Endoscopic ultrasound (EUS) is an excellent tools for evaluating pancreas and peri pancreas region. It also allows us to obtain tissue sample for cytology and histopathology. Here we present a case of peripancreatic tuberculosis lymphadenopathy that mimic pancreatic mass. His symptoms were also nonspecific (weight loss, epigastric pain, and irregular fever). From EUS evaluation we found that there was no mass but multiple lymphadenopathy around the pancreas and then performed FNA. The result of the cytology was granuloma inflammation and caseous necrosis which is compatible with tuberculosis infection. From this case illustration we conclude that EUS is an important diagnostic tool for pancreatic lesion to avoid unnecessary surgery. |
endoscopic ultrasound; lymphadenopathy; Pancreas; tuberculosis |
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NLM (Medline) |
01259326 |
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35027493 |
Article |
Q3 |
321 |
14162 |
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132 |
Rajabto W., Priantono D., Mulyadi R. |
36519576100;57219443427;56403164500; |
Pulmonary Embolism in Hospitalized Patient with Coronavirus Disease 2019 (COVID-19) |
2021 |
Acta medica Indonesiana |
53 |
4 |
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493 |
496 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123461861&partnerID=40&md5=389908dacd77633e6cd2254227617a8c |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo General HospitalJakarta, Indonesia |
Rajabto, W., Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo General HospitalJakarta, Indonesia; Priantono, D.; Mulyadi, R. |
Coronavirus disease 2019 (COVID-19) has been a global pandemic for over a year. Meanwhile, thrombosis occurs in up to one-third of hospitalized patients with the disease, while pulmonary embolism has been reported to be the most dangerous thrombosis which greatly increases mortality in COVID-19.Hospitalized patients with COVID-19 are at high risk of thromboembolic complications such as deep vein thrombosis and pulmonary embolism. The hypercoagulable state caused by COVID-19 leads to activation of coagulation cascade, meanwhile, CT pulmonary angiography is used to diagnose or exclude pulmonary embolism. Furthermore, ground-glass opacities are also evaluated using this modality. Low molecular weight heparin is the anticoagulant of choice due to simplicity in administration and low risk of drug-drug interactions.Pulmonary embolism occurs in COVID-19 patients without DVT. Based on the results, parenteral anticoagulant followed by DOAC is the mainstay of treatment in COVID-19 coagulopathy. |
COVID-19; pulmonary embolism; thrombosis |
anticoagulant agent; complication; diagnostic imaging; human; lung embolism; vein thrombosis; virology; Anticoagulants; COVID-19; Humans; Pulmonary Embolism; SARS-CoV-2; Venous Thrombosis |
NLM (Medline) |
01259326 |
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35027499 |
Article |
Q3 |
321 |
14162 |
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133 |
Shatri H., Prasetyaningtyas A., Putranto R., Rinaldi I. |
28767986500;57426347900;56074051000;23475122400; |
Palliative Prognostic Index Validation in Hospitalized Advanced Cancer Patients in Indonesia Tertiary Hospitals |
2021 |
Acta medica Indonesiana |
53 |
4 |
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442 |
449 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123460876&partnerID=40&md5=6a2a641fbdfa3aa8f7eb17fb4fc4458e |
1. Division of Psychosomatic and Pallliative, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo HospitalJakarta, Indonesia |
Shatri, H., 1. Division of Psychosomatic and Pallliative, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo HospitalJakarta, Indonesia; Prasetyaningtyas, A.; Putranto, R.; Rinaldi, I. |
BACKGROUND: Accurate prediction of survival is important for advanced cancer patients to determine medical interventions plan the patient's lives and prepare for their death. The palliative prognostic index (PPI) is most popular scores used worldwide to predict life expectancy in advanced cancer palliative patients. The purpose of this study was to test validity and the performance of PPI in Cipto Mangunkusumo Hospital as a Tertiary Referral Nasional Hospital. METHODS: This retrospective cohort study, uses total subject during study with consecutive sampling. Palliative prognostic index was assessed by a palliative care team (PCT). Demographic data were summarized as n (%) and Chi square for categorical variables and median or mean for continuous variables. Overall survival was calculated using the Kaplan-Meier method with hazard ratios. The performance of PPI analyzed using SPSS version 20.0, includes for Receiving Operator Characteristics (ROC) and Hosmer-Lemeshow calibration test. RESULTS: 160 patients were included in the PPI study. The subjects have an average age of 50.08 years and are mostly women 68.10%. 28 (17.50%) had symptoms of dyspnoea, 22 (14.60%) pneumonia, and 19 (11.90%) had pain. The number of patients who died during hospitalisation was 83 (51.90%). PPI sum score >6 109 (68,10%). Calibration performance PPI score reached x2 = 8.915 (p = 0.259), and showed correlation r 0.799 (p 0.000). The accuracy of PPI scores in predicting survival in advanced cancer patients in studies for survival <3 weeks 81%, with a sensitivity of 85%, specificity 70%, PPV 86%, and NPV 67%. Predictive accuracy of survival within 3-6 weeks had 76%, sensitivity 66%, specificity 88%, PPV 85% and NPV 70%. PPI score discrimination performance is had a AUC value of 0.822 (95% CI 0.749-0.895). CONCLUSION: Palliative Prognostic Index (PPI ) is valid and has good performance in predicting the survival of advanced cancer patients and may be used to help clinicians in palliative care consultation. |
Cancer; palliative prognostic index (PPI); tertiary hospital; validation |
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NLM (Medline) |
01259326 |
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35027491 |
Article |
Q3 |
321 |
14162 |
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160 |
Yulian E.D., Siregar N.C., Bajuadji |
55983956600;6508087790;57318007000; |
Combination of Simvastatin and FAC Improves Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer |
2021 |
Cancer Research and Treatment |
53 |
4 |
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1072 |
1083 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111269220&doi=10.4143%2fcrt.2020.1024&partnerID=40&md5=fe14ed1b791ebc2592f487892c429602 |
Division of Surgical Oncology, Department of Surgery; Department of Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Koja General Hospital, Jakarta, Indonesia |
Yulian, E.D., Division of Surgical Oncology, Department of Surgery; Siregar, N.C., Department of Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bajuadji, Department of Surgery, Koja General Hospital, Jakarta, Indonesia |
Purpose The efficacy of neoadjuvant chemotherapy for locally advanced breast cancer (LABC) is limited due to drug resistance and cardiotoxic effects. Preclinical studies have shown that statin induces apoptosis and decreases breast cancer cell growth. This study aims to evaluate the role of statin in combination with fluorouracil, adriamycin, and cyclophosphamide (FAC) therapy in LABC patients. Materials and Methods We undertook a randomized, double-blinded, placebo-controlled trial in two centers of Indonesia. Patients were randomly assigned to FAC plus simvastatin (40 mg/day orally) or FAC plus placebo (40 mg/day) for 21 days. The FAC regimen was repeated every 3 weeks. We evaluated the clinical response, pathological response, and toxicities. Results The objective response rate (ORR) for FAC plus simvastatin was 90% (95% confidence interval [CI], 0.99 to 1.67) by per-protocol analysis. No complete responses (CR) were recorded, but there were 48 partial responses. No significant difference was observed between the two groups with the ORR (p=0.103). The pathological CR rate was 6.25% (2 in simvastatin group and 1 in placebo group). Adverse events in both arms were generally mild, mainly consisted of myotoxicity. Human epidermal growth factor receptor 2 (HER2) expression was a factor related to the success of therapeutic response (odds ratio, 4.2; 95% CI, 1.121 to 15.731; p=0.033). Conclusion This study suggests that simvastatin combined with FAC shows improvements in ORR and pathological response in patients with LABC. Although no statistically significant difference was documented, there was a trend for better activity and tolerability. The addition of 40 mg simvastatin may improve the efficacy of FAC in LABC patients with HER2 overexpression. Copyright 2021by theKoreanCancerAssociation |
Breast neoplasms; FAC; Neoadjuvant therapy; Simvastatin |
creatine kinase; cyclophosphamide; doxorubicin; epidermal growth factor receptor 2; fluorouracil; simvastatin; antineoplastic agent; cyclophosphamide; doxorubicin; epidermal growth factor receptor 2; ERBB2 protein, human; fluorouracil; simvastatin; adjuvant therapy; adult; advanced breast cancer; aged; alopecia; anemia; Article; blood toxicity; cancer combination chemotherapy; cancer surgery; clinical outcome; constipation; controlled study; creatine kinase blood level; diarrhea; double blind procedure; drug safety; drug tolerability; fatigue; female; gene overexpression; heart ejection fraction; histopathology; human; hypertransaminasemia; immunohistochemistry; Indonesia; invasive lobular breast carcinoma; leukopenia; lung metastasis; major clinical study; modified radical mastectomy; muc |
Korean Cancer Association |
15982998 |
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33705623 |
Article |
Q1 |
1668 |
1870 |
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191 |
Wahdini S., Putra V.P., Sungkar S. |
57203684068;57299060700;57016857300; |
The prevalence of intestinal protozoan infections among children in southwest sumba based on the type of water sources |
2021 |
Infection and Chemotherapy |
53 |
3 |
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519 |
527 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117295741&doi=10.3947%2fic.2021.0067&partnerID=40&md5=f72157a8065763eba10ce0eed22c987b |
Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Wahdini, S., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Putra, V.P., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sungkar, S., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Intestinal protozoan infection is a public health problem in Indonesia, particularly in regions lacking clean water sources such as Perokonda and Perobatang villages, Southwest Sumba Regency, East Nusa Tenggara Province. The residents of Perokonda and Perobatang villages use wells and unprotected open springs respectively. Therefore, this study aims to determine the prevalence of intestinal protozoan infections in these two villages. Materials and Methods: This was a cross-sectional study, carried out in Perokonda and Perobatang from August 2016 to August 2017. A total of 291 children aged 6 months to 18 years were used as subjects. Furthermore, fecal examinations were carried out by preparing smears, which were stained with lugol solution and examined under the microscopes by four experienced technicians. The data were processed using SPSS version 20 and analyzed by chi-square test. Results: Among the 291 samples, the prevalence of intestinal protozoan infections was 20%, with 23.4% in Perokonda and 17.2% in Perobatang. The predominant species found were Blastocystis hominis (34.5%), Giardia lamblia (19.0%), and Entamoeba coli (15.5%). Moreover, approximately 69.0% of single infections were found while 31.0% were mixed and associated with 2 to 3 protozoan species. There were no significant differences between the prevalence of intestinal protozoan infections and the children in Perokonda and Perobatang villages (confidence interval 0.83 - 2.62, P = 0.19). Conclusion: The type of water sources has no relationship with the species of intestinal protozoan infecting children in Perokonda and Perobatang. © 2021 Korean Society for Antimicrobial Therapy. All rights reserved. |
Children 6 months to 18 years old; Intestinal protozoan; Southwest Sumba; Water sources |
adolescent; adult; Article; Blastocystis hominis; child; controlled study; cross-sectional study; Entamoeba coli; feces analysis; female; Giardia intestinalis; human; infant; intestine infection; major clinical study; male; pediatric patient; prevalence; protozoal infection; water supply |
Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS |
20932340 |
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Article |
Q2 |
724 |
6845 |
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286 |
Wijaya I.P. |
57193731572; |
The Importance of Selecting Permanent Pacemaker, Evaluating the Heart and Assessing Quality of Life in Cardiac Patient |
2021 |
Acta medica Indonesiana |
53 |
3 |
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243 |
244 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117859074&partnerID=40&md5=9e57130d3901679cfdd2331bb124a29a |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Wijaya, I.P., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
The use of pacemakers is necessary for patients with symptomatic bradycardia. Pacemaker implantation also acts as a life-saving procedure. However, there are several reports that patients with a pacemaker (the most widely used pacemaker is on the right ventricle, known as single chamber pacemaker) had disturbances in left ventricle contraction lead to left ventricular systolic dysfunction. Global Longitudinal Strain (GLS) Echocardiography can confirm these left ventricular disturbances. Echocardiography examination is best carried out before and after single-chamber PPM implantation. This study compares PPM placement in apical Right Ventricle (RV) and Right Ventricular Outflow Tract (RVOT) and compares paced QRS duration 150 ms and > 150 ms. Pacing burden >40% causes subclinical left ventricular systolic dysfunction after a month of PPM implantation with decreased GLS in apical RV pacing.This study gives additional information that PPM placement is preferably in RVOT with some specific settings. However, there are many ways to reduce the effects of impaired left ventricular function due to lead installation on the PPM single-chamber device. By using the PPM device which has a dual chamber, the leads will be placed in RVOT and also in the right atrium with atrial-ventricle synchronization. The aim is to avoid impaired left ventricular pump function as supported by a systematic review which states the superiority of dual-chamber PPM over single-chamber PPM in reducing atrial fibrillation and pacemaker syndrome. In the importance of quality of life related to heart disease, the Indonesian version of the MacNew questionnaire can be used. This questionnaire seeks the quality of life of patients with coronary heart disease after revascularization surgery and has undergone rehabilitation. Another important thing is the suitability of the adaptation to the original English version. |
cardiac patient; global longitudinal strain; MacNew questionnaire; pacemaker |
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NLM (Medline) |
01259326 |
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34611061 |
Article |
Q3 |
321 |
14162 |
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287 |
Lydia A., Priantono D., Harimurti K., Alwi I. |
8451287200;57219443427;23473513200;15055173800; |
The Relationship between Folic Acid and Vitamin B12 Serum Levels with High Sensitivity C-reactive Protein and Homocysteine in Chronic Hemodialysis Patients: A Cross-sectional Study |
2021 |
Acta medica Indonesiana |
53 |
3 |
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282 |
290 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117858308&partnerID=40&md5=30f4d1e6b0ba005c917362c78562ed5b |
Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo National HospitalJakarta, Indonesia |
Lydia, A., Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo National HospitalJakarta, Indonesia; Priantono, D.; Harimurti, K.; Alwi, I. |
BACKGROUND: Folic acid (FA) and vitamin B12 treatment have been routinely prescribed to lower serum homocysteine levels and to reduce inflammation. However, no study has been conducted to determine serum folic acid (SFA) and vitamin B12 (B12) levels in patients who have twice-weekly hemodialysis. The aim of our study was to assess serum folate and B12 levels in chronic hemodialysis patients and their relationship with hsCRP and homocysteine levels. METHODS: Our study was a cross-sectional study involcing patients who had twice-weekly hemodialysis in Dr Cipto Mangunkusumo National Hospital Jakarta, Indonesia. Predialysis blood samples were taken to measure SFA, B12, homocysteine and hsCRP levels. Patients with medical conditions affecting the assays were excluded. Spearman correlation was used to compare variables. RESULTS: Eighty subjects enrolled in this study. Among those of non-given folic acid and vitamin B-12 supplementation, only 3.85% of subjects had low folic acid levels, and none had low vitamin B12 levels. A moderate negative correlation between serum folic acid and homocysteine level (p≤0.001; r=-0.42) and a weak correlation between serum vitamin B12 and homocysteine level (p=0.009; r=-0.29) was found. Among the high-risk cardiovascular group (CRP>3, n=49), there is a moderate negative correlation between serum folic acid and homocysteine level (p≤0.001; r=-0.561) and a weak negative correlation between vitamin B12 and homocysteine level (p=0.018; r=-0.338). CONCLUSION: There is a significant negative correlation between serum vitamin B12 and folic acid with homocysteine levels, especially in high-risk cardiovascular group. |
cardiovascular; chronic hemodialysis; CKD; Folic acid; hsCRP; morbidity; mortality; vitamin B12 |
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NLM (Medline) |
01259326 |
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34611067 |
Article |
Q3 |
321 |
14162 |
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