No records
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446 |
Damanik J., Yunir E. |
57211582841;36520254800; |
Type 2 Diabetes Mellitus and Cognitive Impairment |
2021 |
Acta medica Indonesiana |
53 |
2 |
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213 |
220 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111560209&partnerID=40&md5=8b6a3af63f3b7bd6c8c50f2cf6ec2509 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Damanik, J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Yunir, E. |
Type 2 diabetes mellitus (T2DM) is strongly associated with lower performance on multiple domains of cognitive function and with structural abnormalities of the brain. With the growing epidemic of diabetes and aging population, neural complications of diabetes are expected to rise and becoming a challenge for future health implications. Understanding pathophysiology, factors associated with this complication, manifestation of cognitive impairment and various metabolic and neuroradiologic markers suggestive of this pathologic condition is crucial for proper management of this potentially debilitating complication of T2DM. This review will discuss briefly important aspects of cognitive impairment in T2DM. |
cognitive impairment; type 2 diabetes mellitus |
biological marker; aged; brain; cognition; human; non insulin dependent diabetes mellitus; pathology; pathophysiology; Aged; Biomarkers; Brain; Cognition; Diabetes Mellitus, Type 2; Humans |
NLM (Medline) |
01259326 |
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34251351 |
Review |
Q3 |
321 |
14162 |
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447 |
Nugroho P., Lydia A., Suhardjono S., Harimurti K. |
55987056300;8451287200;57218776121;23473513200; |
Association of BsmI Polymorphisms in the Vitamin D Receptor Gene Among Indonesian Population with Diabetic Kidney Disease |
2021 |
Acta medica Indonesiana |
53 |
2 |
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149 |
155 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111468637&partnerID=40&md5=791ec67dac5f5065a522a04484329da4 |
Division of Nephrology and Hypertension, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nugroho, P., Division of Nephrology and Hypertension, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo HospitalJakarta, Indonesia; Lydia, A.; Suhardjono, S.; Harimurti, K. |
BACKGROUND: Diabetic kidney disease (DKD), as a common cause of end-stage renal disease (ESRD), is a chronic complication of diabetes mellitus (DM). It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. This study aimed to analyze the association between VDR polymorphisms and DKD in Indonesian population, also risk factors that influence it. METHODS: a cross-sectional study was conducted in Type 2 DM patients who visited internal medicine outpatient clinic at Dr. Cipto Mangunkusumo Hospital, Jakarta, from November 2014 until March 2015. Data collection includes characteristics of subjects and laboratory examination, including BsmI polymorphisms in the vitamin D receptor gene. Patients with acute and severe disease were excluded from the study. Bivariate and multivariate analyses were done. RESULTS: of 93 DM subjects, 42 (45.2%) subjects were without DKD and 51 (54.8%) subjects had DKD. Most of the subjects had the Bb genotype (89.2%), with no subject having the BB genotype. The proportions of the B and b alleles were 44.6% and 55.4%, respectively. There is no association between BsmI polymorphisms in the vitamin D receptor gene and DKD (OR = 1.243; CI 95% 0.334-4.621; p value = 0.751). CONCLUSION: the profile of BsmI polymorphisms in the vitamin D receptor gene in the Indonesian population were genotypes Bb (89.2%) and bb (10.8%). There was no association between BsmI polymorphisms in the vitamin D receptor gene and DKD. Duration of DM more than five years influenced the association between those variables. |
BsmI; diabetic kidney disease; Indonesia-Malay race; polymorphisms; vitamin D receptor (VDR) gene |
calcitriol receptor; VDR protein, human; aged; blood; case control study; complication; cross-sectional study; diabetic nephropathy; female; genetic polymorphism; genetics; genotype; human; Indonesia; male; middle aged; non insulin dependent diabetes mellitus; risk factor; very elderly; Aged; Aged, 80 and over; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Genotype; Humans; Indonesia; Male; Middle Aged; Polymorphism, Genetic; Receptors, Calcitriol; Risk Factors |
NLM (Medline) |
01259326 |
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34251342 |
Article |
Q3 |
321 |
14162 |
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448 |
Syam A.F., Pitoyo C.W., Suhendro S., Zulkarnain B., Indrasari N.D., Aditianingsih D., Irawan C., Susilo A., Rumende C.M., Wijaya I.P., Ibrahim F., Rasmin M., Alwi I., Makmun D. |
8443384400;26022606900;8443626100;57226403717;6506289872;56312263600;28767651600;57217867079;14325966300;57221504958;57226400046;15754578700;15055173800;16638046900; |
Tocilizumab as a Treatment for 'Cytokine Storm Syndrome' in COVID-19: A Case Report |
2021 |
Acta medica Indonesiana |
53 |
2 |
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194 |
201 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111460182&partnerID=40&md5=9fddc7ae8a7dbf93ea0a07158c0ab2b2 |
Fellow of the American College of Physicians; Division of Gastroenterology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Syam, A.F., Fellow of the American College of Physicians; Division of Gastroenterology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pitoyo, C.W.; Suhendro, S.; Zulkarnain, B.; Indrasari, N.D.; Aditianingsih, D.; Irawan, C.; Susilo, A.; Rumende, C.M.; Wijaya, I.P.; Ibrahim, F.; Rasmin, M.; Alwi, I.; Makmun, D. |
Coronavirus disease 19 (COVID-19) which is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been a problem worldwide, particularly due to the high rate of transmission and wide range of clinical manifestations. Acute respiratory distress syndrome (ARDS) and multiorgan failure are the most common events observed in severe cases and can be fatal. Cytokine storm syndrome emerges as one of the possibilities for the development of ARDS and multiorgan failure in severe cases of COVID-19. This case report describes a case of a 53-year-old male patient who has been diagnosed with COVID-19. Further evaluation in this patient showed that there was a marked increase in IL-6 level in blood accompanied with hyperferritinemia, which was in accordance with the characteristic of cytokine storm syndrome. Patient was treated with tocilizumab, a monoclonal antibody and is an antagonist to IL-6 receptor. The binding between tocilizumab and IL-6 receptors effectively inhibit and manage cytokine storm syndrome. Although this case report reported the efficacy of tocilizumab in managing cytokine storm syndrome, tocilizumab has several adverse effects requiring close monitoring. Further clinical randomized control trial is required to evaluate the efficacy and safety of tocilizumab administration in participants with various clinical characteristics and greater number of subjects. |
acute respiratory distress syndrome (ARDS); COVID-19; SARS-CoV-2; Tocilizumab |
biological marker; interleukin 6; monoclonal antibody; tocilizumab; blood; case report; complication; cytokine release syndrome; human; male; middle aged; Antibodies, Monoclonal, Humanized; Biomarkers; COVID-19; Cytokine Release Syndrome; Humans; Interleukin-6; Male; Middle Aged; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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34251348 |
Article |
Q3 |
321 |
14162 |
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449 |
Rumende C.M. |
14325966300; |
Pulmonary Fibrosis Caused by Severe COVID-19 Infection: Discharge May Not Be The End of Treatment |
2021 |
Acta medica Indonesiana |
53 |
2 |
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141 |
142 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111424385&partnerID=40&md5=313ffbbdaf35e6b4ca2305e0cfcfa1a4 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Rumende, C.M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Since December 2019, COVID-19 caused by SARS-CoV-2 infection has been spread rapidly in the world. Beside acute respiratory distress syndrome found in acute phase of infection, there is also pulmonary fibrosis as a chronic complication due to COVID-19. With the global pandemic of COVID-19, more and more autopsy and puncture histopathological results have been published.Until now there is no specific therapy to handle post-inflammatory pulmonary fibrosis due to COVID-19 infection. Several studies are ongoing to determine an effective treatment for this chronic complication. While ARDS appears to be the main cause of pulmonary fibrosis in COVID-19, the pathogenesis of ARDS caused by SARS-CoV-2 is different from the typical ARDS. Some therapies may be considered for reducing the fibrosis process in lung after COVI-19 infection namely pirfenidone, nintedanib and mesenchymal stem cells. Many patients are still recovering spontaneously in the first six weeks after acute COVID-19 infection and do not generally require fast-track entry into a pulmonary rehabilitation programme. However, those who have significantly persistent respiratory illness may need to be supported by pulmonary rehabilitation. Multidisciplinary intervention based on personalized evaluation and treatment which includes exercise training, education and behavioral modification can be given to improve the physical and psychological condition of patients with post-COVID pulmonary fibrosis. |
COVID-19; Indonesia; pulmonary fibrosis |
complication; hospital discharge; human; lung fibrosis; pandemic; virology; virus pneumonia; COVID-19; Humans; Pandemics; Patient Discharge; Pneumonia, Viral; Pulmonary Fibrosis; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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34251340 |
Editorial |
Q3 |
321 |
14162 |
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486 |
Irdam G.A., Raharja P.A.R., Sutojo B., Situmorang G.R. |
57194729795;57201013616;57218247988;57190001213; |
Predictive Model of Ureteral Obstruction of Allograft Kidney Following Living Donor Kidney Transplantation |
2021 |
Transplantation Proceedings |
53 |
3 |
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1064 |
1069 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097068797&doi=10.1016%2fj.transproceed.2020.10.022&partnerID=40&md5=bf23ded4b9ef76b3a0dac07ece50cf93 |
Department of Urology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irdam, G.A., Department of Urology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sutojo, B., Department of Urology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Situmorang, G.R., Department of Urology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Ureteral obstruction is one of the most frequent urologic complications of kidney transplantation. This study aimed to analyze independent factors that contribute to ureteral obstruction following kidney transplantation and develop predictive models form those factors. Methods: As many as 545 kidney transplantations were analyzed. Patients underwent transplantation between January 2014 and December 2018. Logistic regression analysis was used to develop the predictive model. Both donor and recipient demographic characteristics and operative parameters were analyzed and presented. Results: There were 37 (6.8%) subjects who developed ureteral obstruction. The independent risk factors for ureteral obstruction were multiple allograft renal arteries, older donor ages (>38 years), and older recipient age (>60 years). From the receiver operating characteristic (ROC) curve analysis, the area under the ROC curve of the predictive model was 0.843 (P < .001). Subjects with >2 renal allograft arteries, recipient age >60 years, and donor age >38 years had 83.8% probability of developing ureteral stenosis after kidney transplantation. Conclusion: Donor age, recipient age, and multiple renal arteries were independent risk factors of graft ureteral obstruction. Probability of developing ureteral obstruction should be considered pre-operatively in our population, using the proposed predictive model. © 2020 Elsevier Inc. |
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adult; allograft; Article; demography; female; graft recipient; groups by age; human; kidney donor; kidney graft; kidney transplantation; living donor; major clinical study; male; middle aged; prediction; priority journal; retrospective study; risk factor; ureter obstruction; adverse event; age; allograft; kidney; kidney artery; kidney transplantation; living donor; postoperative complication; procedures; receiver operating characteristic; statistical model; transplantation; ureter obstruction; vascularization; Adult; Age Factors; Allografts; Clinical Decision Rules; Female; Humans; Kidney; Kidney Transplantation; Living Donors; Logistic Models; Male; Middle Aged; Postoperative Complications; Renal Artery; Retrospective Studies; Risk Factors; ROC Curve; Ureteral Obstruction |
Elsevier Inc. |
00411345 |
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33248722 |
Article |
Q3 |
373 |
12773 |
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526 |
Pudjiadi A.H., Antonjaya U., Myint K.S., Alatas F.S. |
18435202300;36016109600;7003758970;57217150164; |
Echovirus-7 infection in children with unusual severe manifestation: A case report |
2021 |
Infection and Chemotherapy |
53 |
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141 |
145 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104262436&doi=10.3947%2fIC.2020.0081&partnerID=40&md5=80e71bfc568af5c4cf2736e907d992fe |
Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Eijkman Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Emerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Antonjaya, U., Eijkman Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S., Emerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Alatas, F.S., Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
We report a rare laboratory-confirmed, clinical case of Echovirus-7 infection in an immunocompetent child with central nervous system and systemic manifestation. Echovirus infection is usually mild, however in this case we identified echovirus-7 infection with 91% homology with the Echovirus-7 strain previously isolated in neighbouring country with severe manifestation. Copyright © 2021 by The Korean Society of Infectious Diseases, |
Echovirus-7; Encephalitis; Enterovirus; QRT-PCR; Sepsis |
cephalosporin; phenobarbital; procalcitonin; thromboplastin; valproic acid; Article; blood gas analysis; breathing rate; case report; cerebrospinal fluid; childhood disease; clinical article; differential diagnosis; digestive system injury; disease severity; disseminated intravascular clotting; echovirus 7 infection; Echovirus infection; ego development; emergency ward; family history; fever; Glasgow coma scale; heart rate; hemoglobin blood level; hospital admission; hospitalization; human; hypokalemia; infant; laboratory test; leukopenia; lung auscultation; male; nose smear; nucleotide sequence; physical examination; platelet count; prothrombin time; Pseudomonas aeruginosa; real time reverse transcription polymerase chain reaction; rectal swab; rectal temperature; seizure; sepsis; sputum |
Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS |
20932340 |
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Article |
Q2 |
724 |
6845 |
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668 |
Soebandrio A., Kusumaningrum T., Yudhaputri F.A., Oktavianthi S., Safari D., Malik S.G., Myint K.S.A. |
8602893200;55533156000;56464244900;38361976900;23493586700;7402973374;7003758970; |
COVID-19 prevalence among healthcare workers in Jakarta and neighbouring areas in Indonesia during early 2020 pandemic |
2021 |
Annals of Medicine |
53 |
1 |
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1896 |
1904 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119260631&doi=10.1080%2f07853890.2021.1975309&partnerID=40&md5=1449d652b75cc7277061a388d5491234 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kusumaningrum, T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Yudhaputri, F.A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Oktavianthi, S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S.A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Background: The COVID-19 disease has overwhelmed and disrupted healthcare services worldwide, particularly healthcare workers (HCW). HCW are essential workers performing any job in a healthcare setting who are potentially directly or indirectly exposed to infectious materials. Our retrospective cohort study aimed to determine the prevalence of COVID-19 infections among HCW in Jakarta and neighbouring areas during the first three months of the pandemic. Methods: Nasopharyngeal/oropharyngeal swab specimens from HCW working at private and public hospitals in Jakarta and neighbouring areas were screened for SARS-CoV-2 between March and May 2020. Data on demography, clinical symptoms, contact history, and personal protective equipment (PPE) use were collected using standardised forms. Results: Among 1201 specimens, 7.9% were confirmed positive for SARS-CoV-2 with the majority coming from medical doctors (48.4%) and nurses (44.2%). 64.2% of the positive cases reported to have contact with suspect/confirmed COVID-19 cases, including 32 (52.2%) with patient and 3 (6.6%) with co-worker. The symptomatic HCW had a significantly lower median Ct value as compared to their asymptomatic counterpart (p <.001). Tendency to have a higher prevalence of pneumonia was observed in the age group of 40–49 and ≥50 years old. Conclusion: Our findings highlighted the necessity to implement proper preventive and surveillance strategies for this high-risk population including adherence to strict PPE protocol and appropriate training.Key Message Healthcare workers (HCW), defined as those handling any job in a healthcare setting, are at the frontline of risk of infection as SARS-CoV-2 is easily transmitted through airborne droplets and direct contact with contaminated surfaces. The aim of our study is to attain a more comprehensive and accurate picture of the impact of COVID-19 on HCW during the earlier phase of the outbreak in Indonesia to develop effective strategies that protect the health and safety of this workforce. Our findings highlighted that COVID-19 infections in HCW were mostly acquired in healthcare settings, with significant consequences of pneumonia and hospitalisation occurring across all age groups. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
COVID-19; healthcare workers; Indonesia; transmission |
abdominal pain; adult; Article; cohort analysis; contact examination; controlled study; coronavirus disease 2019; coughing; demography; diarrhea; dizziness; dyspnea; female; headache; health care personnel; health status; human; Indonesia; major clinical study; malaise; male; medical history; myalgia; nasopharyngeal swab; neurologist; oropharyngeal swab; pandemic; pharmacist; physiotherapist; prevalence; private hospital; prospective study; public hospital; retrospective study; reverse transcription polymerase chain reaction; rhinorrhea; shivering; sore throat; thorax radiography; vomiting; aged; epidemiology; health care personnel; middle aged; prevalence; Adult; Aged; COVID-19; Female; Health Personnel; Humans; Indonesia; Male; Middle Aged; Pandemics; Prevalence; Retrospective Studies; S |
Taylor and Francis Ltd. |
07853890 |
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34783269 |
Article |
Q1 |
1150 |
3535 |
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828 |
Suryana K.D., Simadibrata M., Renaldi K. |
57222750873;23499598400;57190963547; |
Impact of COVID-19 on the Gut: A Review of the Manifestations, Pathology, Management, and Challenges |
2021 |
Acta medica Indonesiana |
53 |
1 |
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96 |
104 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103994291&partnerID=40&md5=8f9253303dd7921abe223346263c353b |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital National HospitalJakarta, Indonesia |
Suryana, K.D., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital National HospitalJakarta, Indonesia; Simadibrata, M.; Renaldi, K. |
SARS-CoV-2 is a virus that can enter its hosts through the Angiotensin Converting Enzyme-2 (ACE2) receptor. ACE2 is mainly expressed in cells of the gastrointestinal tract, such as the esophageal epithelium and enterocytes from the ileum-colon. Coronavirus Disease 2019 (COVID-19) has varying clinical symptoms and presents differently in individuals, ranging from asymptomatic carriers to moderate clinical spectrum with mild pneumonia clinical features, and to a severe clinical presentation with dyspnea and hypoxia, leading to death due to respiratory or multi-organ failure. COVID-19 infection can also manifest themselves in the form of gastrointestinal symptoms such as diarrhea, vomiting, nausea, and abdominal pain. Severe complications of gastrointestinal COVID-19 infections include hemorrhage or perforation of the gastrointestinal tract and severe inflammation, which can adversely affect the intestinal immune system, and therefore the systemic immune system of the host. Furthermore, COVID-19 has also shown to affect microbiota homeostasis in the digestive tract. To date, no clear explanation is available regarding the pathophysiology of gastrointestinal SARS-CoV-2 infection, fecal RNA detection, and the possibility of fecal-oral transmission of SARS-CoV-2. This review aims to discuss the effects of SARS-CoV-2 infection on the digestive tract, microbiota, and lung, and the possibility of fecal-oral transmission in COVID-19. |
Gastroenterology; Hepatology; Infection; Internal medicine; Pulmonology; Tropical disease |
feces; gastrointestinal disease; gastrointestinal tract; human; immunology; isolation and purification; pathogenicity; pathophysiology; physiology; prevention and control; virology; COVID-19; Feces; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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33818412 |
Review |
Q3 |
321 |
14162 |
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829 |
Azwar M.K., Setiati S. |
57202798959;14325991900; |
Modifiable Risk Factors for Dementia in Indonesia's Urban Population |
2021 |
Acta medica Indonesiana |
53 |
1 |
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31 |
41 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993731&partnerID=40&md5=7f5fcb58c59d74fc45c0cac2c49add86 |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Azwar, M.K., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Setiati, S. |
BACKGROUND: Indonesia is one of ten countries in the world with estimated number of dementia case exceeding a million. The number of elderly population living in Indonesian cities has exceeded the number in rural areas, but the country lacks data representing the urban population better related to modifiable risk factors for dementia, prevention of which is crucial. We aimed to identify the modifiable risk factors for dementia in Indonesia's urban population. METHODS: this case-control study used five-year data in Indonesia's national general hospital by tracing back medical record books of individuals aged 60 years and above in geriatric medicine outpatient clinic to the first hospital visit. Statistical analyses included bivariate and multivariate analyses to adjust for confounding factors appropriately. RESULTS: data from 345 patients suggested that the significant risk factors for dementia were history of smoking (adjusted OR 2.860, 95% CI 1.559-5.246), history of hearing loss (adjusted OR 7.962, 95% CI 3.534-17.941), history of depression (adjusted OR 12.473, 95% CI 2.533-61.417), hypertension (adjusted OR 1.751, 95% CI 1.006-3.048), and diabetes mellitus (adjusted OR 2.561, 95% CI 1.482-4.425). Dementia patients had longer median duration of diabetes mellitus (12 years) than elderly without dementia (9 years) before the diagnosis of dementia. Single point late-life underweight condition and low educational attainment were not associated with dementia in Indonesia's urban setting. The risk factors for vascular dementia were largely similar to those of dementia. CONCLUSION: in Indonesian urban population, history of smoking, hearing loss, depression, hypertension, and diabetes mellitus are associated with dementia. |
city; dementia; Indonesia; Jakarta; risk factor; urban |
adverse event; aged; case control study; complication; dementia; depression; diabetes mellitus; female; hearing impairment; human; hypertension; Indonesia; male; middle aged; multivariate analysis; risk factor; smoking; statistical model; urban population; very elderly; Aged; Aged, 80 and over; Case-Control Studies; Dementia; Depression; Diabetes Mellitus; Female; Hearing Loss; Humans; Hypertension; Indonesia; Logistic Models; Male; Middle Aged; Multivariate Analysis; Risk Factors; Smoking; Urban Population |
NLM (Medline) |
01259326 |
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33818405 |
Article |
Q3 |
321 |
14162 |
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830 |
Wicaksono I., Rahardjo H.E. |
57217251974;37762030000; |
Diagnostic Value of PCR compared to Urine Culture for Urinary Tuberculosis in Adult Women: An Evidence-Based Case Report |
2021 |
Acta medica Indonesiana |
53 |
1 |
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108 |
118 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993519&partnerID=40&md5=7a612f7f41fa8ec9b31840cc9700f185 |
Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Wicaksono, I., Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Rahardjo, H.E. |
BACKGROUND: genitourinary tuberculosis (GUTB) refers to a Mycobacterium tuberculosis infection of the urinary tract with clinical manifestation masquerading as various urological diagnostic entities. With an incidence rate of 192-232 per 100,000 individuals, current diagnoses have fallen short in comparison to the total incidence. Combined with an atypical and non-specific manifestation, a high false negative rate of acid-fast bacilli (AFB) staining, and long AFB culture duration has made diagnosis difficult. We aim to gather current available evidence regarding the diagnostic performance of polymerase chain reaction (PCR) in the diagnosis of GUTB. METHODS: a literature search was conducted in four different, well-known databases using a predetermined PICO, keywords, and Boolean operators. All included articles will be subjected to rigorous appraisal according the University of Oxford's Centre for Evidence-Based Medicine (CEBM) Diagnostic Variability Criteria. Review and meta-analysis will be subjected to the QFAITH appraisal checklist to assess its quality. RESULTS: out of a total of 243 initial search results, 11 relevant studies were determined after title and abstract screening. Additionally, nine articles were excluded based on the predetermined criteria. Two fully appraised articles were included in the study: one systematic review article, revealing a heterogenous (I2 = unstated; p = unstated) result of sensitivity mean above 85% and specificity above 75%; and one cross-sectional diagnostic study that reported the use of two different PCR primers: IS6110-PCR and 16SrRNA-PCR primer with a sensitivity of 95.99% and 87.05% and specificity of 98.11% and 98.9%, respectively. CONCLUSION: current limited evidence showed that PCR could not be solely used for the diagnosis of GUTB, but its use is recommended to guide patient treatment and monitoring. |
acid-fast bacilli; diagnosis; genitourinary tuberculosis; polymerase chain reaction; urine culture |
adult; case report; comparative study; evidence based practice; female; genetics; human; isolation and purification; meta analysis; microbiology; Mycobacterium tuberculosis; polymerase chain reaction; sensitivity and specificity; urine; urogenital tuberculosis; Adult; Evidence-Based Practice; Female; Humans; Mycobacterium tuberculosis; Polymerase Chain Reaction; Sensitivity and Specificity; Tuberculosis, Urogenital; Urine |
NLM (Medline) |
01259326 |
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33818414 |
Article |
Q3 |
321 |
14162 |
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