No records
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281 |
Gani A.Z., Zahra P.K., Soedarsono N., Yunaini L., Auerkari E.I. |
57222626782;57226565453;14049161500;57192911515;10139113000; |
Vitamin D receptor TaqI (rs731236) gene polymorphism in caries patients |
2021 |
Journal of Physics: Conference Series |
1943 |
1 |
012093 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112014710&doi=10.1088%2f1742-6596%2f1943%2f1%2f012093&partnerID=40&md5=5891ab3c26dbd9bd14c0be24643600b3 |
Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Gani, A.Z., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Zahra, P.K., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia |
Vitamin D receptor (VDR) is included in the type of protein that serves as the biological function regulator of vitamin D. Tooth formation, especially in enamel and dentin calcification, as well as maintaining the balance of phosphate and calcium ions which is an important factor in protecting teeth requires support from vitamin D. The VDR gene will regulate the activity of VDR proteins. Caries is a multifactorial disease in which genetic factors can affect the host susceptibility to caries. Polymorphism in the VDR gene is suspected to affect the host susceptibility to caries through changes in calcium metabolism. This study aims to discover the VDR gene polymorphism and its association with caries patients in Indonesia. 100 DNA samples from 100 blood samples, including 50 dental caries patients and 50 healthy controls, were analyzed using PCR-RFLP technique. PCR products were digested with the TaqI restrictive enzyme, then assessed with statistical analysis using Fisher's exact test and Continuity correction test. In the caries group, there were no samples with CC genotype, 4 samples with CT genotype, and 46 samples with TT genotype. There were also 4 C alleles and 96 T alleles. Polymorphic genotypes and alleles were found higher in the caries group (100% and 96%) than healthy controls (88% and 84%). These results conclude that the polymorphism of VDR TaqI (rs731236) gene was found in patients with dental caries. The distribution of genotypes and allele distributions of VDR TaqI (rs731236) gene between caries and healthy controls significantly differs noticeable (p <0.05). © Published under licence by IOP Publishing Ltd. |
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Biomineralization; Calcium; Polymerase chain reaction; Polymorphism; Proteins; Vitamins; Biological functions; Calcium metabolism; Continuity corrections; Gene polymorphism; Healthy controls; Host susceptibility; Multifactorial disease; Vitamin D receptor; Genes |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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282 |
Lazarus G., Wangsaputra V.K., Christianto, Louisa M., Soetikno V., Hamers R.L. |
57214599425;57215576000;57223348000;41461551400;36769252100;23034345900; |
Safety and Pharmacokinetic Profiles of Long-Acting Injectable Antiretroviral Drugs for HIV-1 Pre-Exposure Prophylaxis: A Systematic Review and Meta-analysis of Randomized Trials |
2021 |
Frontiers in Pharmacology |
12 |
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664875 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111311631&doi=10.3389%2ffphar.2021.664875&partnerID=40&md5=708eaf175b9ad89a98ff6679c222f1c7 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wangsaputra, V.K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Christianto, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Objectives: To investigate the safety and pharmacokinetic profiles of long-acting injectable pre-exposure prophylaxis (LAI PrEP), notably cabotegravir (CAB-LA) and rilpivirine (RPV-LA), for the prevention of human immunodeficiency virus-1 (HIV-1) infection. Methods: Eligible randomized trials of LAI PrEP in HIV-uninfected and/or healthy patients were included and assessed with the Revised Cochrane risk-of-bias tool for randomized trials. Where feasible, a meta-analysis was performed for safety outcomes by using a random-effects model with risk ratios and their 95% confidence intervals as the common effect measure. The protocol was registered with PROSPERO CRD42020154772. Results: Eight studies cumulating a total of 666 participants were included in this systematic review, including five (362 intervention-arm volunteers) and four trials (194 intervention-arm volunteers) that investigated CAB-LA and RPV-LA, respectively. We found that both CAB-LA and RPV-LA were generally well-tolerated as their safety profiles were similar to placebo in terms of any adverse event (AE), serious AE, and AE-related withdrawals. Furthermore, pharmacokinetic analyses revealed favorable prospects in viral inhibitory activity of CAB-LA and RPV-LA. Intramuscular (IM) injection of CAB-LA 600 mg Q8W was superior to CAB-LA 800 mg Q12W in male participants, while the same was true for RPV-LA 1200 mg IM Q8W over other dosing regimens. Although these results are promising, further research is required to confirm the findings on RPV-LA as current evidence is limited. Conclusion: CAB-LA and RPV-LA have promising safety and pharmacokinetic profiles. The preventive efficacy of these agents is being evaluated in Phase 3 trials. © Copyright © 2021 Lazarus, Wangsaputra, Christianto, Louisa, Soetikno and Hamers. |
cabotegravir; HIV-human immunodeficiency virus; long acting injectable (LAI); pre-exposure (PrEP) prophylaxis; rilpivirine |
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Frontiers Media S.A. |
16639812 |
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Review |
Q1 |
1384 |
2619 |
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283 |
Meilia P.D.I., Zeegers M.P., Herkutanto, Freeman M.D. |
57204065074;7003691618;57204069374;34769701500; |
Medicolegal causation investigation of bacterial endocarditis associated with an oral surgery practice using the INFERENCE approach |
2021 |
International Journal of Environmental Research and Public Health |
18 |
14 |
7530 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110118162&doi=10.3390%2fijerph18147530&partnerID=40&md5=c18a2f743bdf484bc116e962d9bb593b |
Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Department of Forensic Medicine and Medicolegal Studies, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 4, Salemba, Jakarta Pusat, 10430, Indonesia |
Meilia, P.D.I., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Zeegers, M.P., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Herkutanto, Department of Forensic Medicine and Medicolegal Studies, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 4, Salemba, Jakarta Pusat, 10430, Indonesia; Freeman, M.D., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands |
Investigating causation is a primary goal in forensic/legal medicine, aiming to establish the connection between an unlawful/negligent act and an adverse outcome. In malpractice litigation involving a healthcare-associated infection due to a failure of infection prevention and control prac-tices, the medicolegal causal analysis needs to quantify the individual causal probabilities to meet the evidentiary requirements of the court. In this paper, we present the investigation of the most probable cause of bacterial endocarditis in a patient who underwent an invasive procedure at a dental/oral surgical practice where an outbreak of bacterial endocarditis had already been identified by the state Department of Health. We assessed the probability that the patient’s endocarditis was part of the outbreak versus that it was an unrelated sporadic infection using the INFERENCE (Integration of Forensic Epidemiology and the Rigorous Evaluation of Causation Elements) approach to medicolegal causation analysis. This paper describes the step-by-step application of the INFERENCE approach to demonstrate its utility in quantifying the probability of causation. The use of INFERENCE provides the court with an evidence-based, transparent, and reliable guide to determine liability, causation, and damages. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Bacterial endocarditis; Infection prevention and control practices; INFERENCE approach; Malpractice litigation; Medicolegal causal analysis; Quantification of causation |
bacterium; disease control; forensic science; health care; infectious disease; medicine; oral health; quantitative analysis; adult; aged; aortic regurgitation; Article; bacteremia; bacterial endocarditis; cardiomegaly; dizziness; dyspnea; electrocardiography; emergency ward; Enterococcus faecalis; female; fever; follow up; hospitalization; human; infection prevention; legal epidemiology; lumpectomy; male; malpractice; night sweat; nuclear magnetic resonance imaging; oral surgery; public health; transesophageal echocardiography; bacterial endocarditis; causality; forensic medicine; malpractice; Bacteria (microorganisms); Causality; Endocarditis, Bacterial; Forensic Medicine; Humans; Malpractice; Oral Surgical Procedures |
MDPI |
16617827 |
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34299979 |
Article |
Q2 |
747 |
6560 |
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284 |
Rustamadji P., Takbir M., Wuyung P.E., Kusmardi K., Wiyarta E. |
55321572200;57318063000;57192889605;56966625300;57221521342; |
Correlation between CD 34 and CD 68 expression in placental malaria with maternal anemia |
2021 |
Tropical Parasitology |
11 |
2 |
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92 |
96 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118308075&doi=10.4103%2ftp.TP_108_20&partnerID=40&md5=a57c3187c0926ddc2e00415c87f7f7bb |
Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Labuha Hospital, North Maluku, South Halmahera, Indonesia |
Rustamadji, P., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Takbir, M., Department of Anatomical Pathology, Labuha Hospital, North Maluku, South Halmahera, Indonesia; Wuyung, P.E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Malaria is the second most life-threatening infectious disease in Indonesia, causing approximately 1-3 million deaths annually. Histopathologic studies assessing CD 68 and CD 34 protein expression in placental malaria and its association with maternal anemia are essential to determine the prognosis of malaria in pregnancy. Materials and Methods: This cross-sectional study was carried out in 2017. Thirty biopsy samples of human placental tissue were obtained from Timika and Sumba, and ten normal biopsy samples were taken from the Pathological Anatomy Department of Cipto Mangunkusumo General Hospital as comparisons. CD 34 and CD 68 protein expressions were determined using immunohistochemistry, and the resulting data were analyzed using SPSS. Results: Average hemoglobin (Hb) level was 9.5 mg/dL, 11.5 mg/dL, and 9.9 mg/dL in acute infection, chronic infection, and latent infection, respectively. A positive correlation was found between CD 68 protein expression and maternal Hb level. No correlation was found between CD34 expression and maternal anemia. Conclusions: CD 68 expression in placental tissue biopsy from Timika and Sumba residents with placental malaria was shown to be positively correlated with maternal anemia. Immunohistochemical examination of CD 68 may play a role in the early diagnosis of malaria. © 2021 Tropical Parasitology | Published by Wolters Kluwer - Medknow. |
CD 34; CD 68; Maternal anemia; Placental malaria |
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Wolters Kluwer Medknow Publications |
22295070 |
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Article |
Q3 |
418 |
11707 |
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285 |
MANSYUR A.S., WIDYAHENING I.S., SUDARSONO N.C. |
57312107800;54893154400;57201862518; |
Incidence of musculoskeletal injuries among Indonesian volleyball athletes during a national training and championship |
2021 |
Gazzetta Medica Italiana Archivio per le Scienze Mediche |
180 |
7-8 |
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374 |
379 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117904317&doi=10.23736%2fS0393-3660.20.04382-X&partnerID=40&md5=706fa0522bf3dbc8cae2b23a407d416b |
Sports Medicine Study Program, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Family Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Sports Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
MANSYUR, A.S., Sports Medicine Study Program, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; WIDYAHENING, I.S., Division of Family Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; SUDARSONO, N.C., Division of Sports Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: This study aimed to find out the incidence and characteristics of musculoskeletal injuries among Indonesian volleyball athletes during a national volleyball training and championship. METHODS: A prospective cohort study involving 34 Indonesian volleyball national team athletes (18 male and 16 female) during one volleyball national training and championship in July-September 2019 was conducted. All athletes were observed for 11 weeks and the incidence and the characteristics (duration, pain level, severity in loss time, nature, recurrence, anatomical location and types) of the injuries were documented. Some etiological factors of the injuries such as the court zone (back, front/net, and un-specified) time of injury (practice, competition or both), injury mechanism (ball contact, player contact, surface contact, non-contact or overuse), biomechanics (bending, compression, repetitive or traction) and movements (blocking, digging, passing, serving, spiking, or not specific) were also recorded. Incidence of injuries was presented in 1000 player hours. RESULTS: The incidence of injuries was 20.4/1000 player hours. Only one out of the 34 athletes did not have injury. Injuries occurred most frequently in the knee (36%), followed by the ankle (18%) and waist (16%). The most common type of injuries was sprain (21%) and tendinitis (21%) followed by low back pain (13%). The overuse and recurrence type of injuries were much more dominant to the acute one. CONCLUSIONS: Musculoskeletal injuries were common among Indonesian volleyball athletes. This adds information to the limited available evidence concerning the incidence, prevalence and etiology of volleyball-specific injuries which were needed to prevent its occurrence. © 2021 Edizioni Minerva Medica. All rights reserved. |
Athletes; Cumulative trauma disorders; Sports medicine; Volleyball |
adult; ankle; Article; athlete; beep test; biomechanics; body mass; bursitis; cardiopulmonary endurance; clinical article; cohort analysis; compression; concussion; court; elbow; female; hand-grip strength test; head; human; incidence; Indonesian; knee; low back pain; male; maximal oxygen uptake; muscle exercise; muscle strength; musculoskeletal injury; nuclear magnetic resonance imaging; patellofemoral pain syndrome; physical examination; prospective study; shoulder; shuttle run test; situp test; sprain; tendinitis; training; volleyball; x-ray computed tomography |
Edizioni Minerva Medica |
03933660 |
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Article |
Q4 |
114 |
27889 |
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286 |
Wijaya I.P. |
57193731572; |
The Importance of Selecting Permanent Pacemaker, Evaluating the Heart and Assessing Quality of Life in Cardiac Patient |
2021 |
Acta medica Indonesiana |
53 |
3 |
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243 |
244 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117859074&partnerID=40&md5=9e57130d3901679cfdd2331bb124a29a |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Wijaya, I.P., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
The use of pacemakers is necessary for patients with symptomatic bradycardia. Pacemaker implantation also acts as a life-saving procedure. However, there are several reports that patients with a pacemaker (the most widely used pacemaker is on the right ventricle, known as single chamber pacemaker) had disturbances in left ventricle contraction lead to left ventricular systolic dysfunction. Global Longitudinal Strain (GLS) Echocardiography can confirm these left ventricular disturbances. Echocardiography examination is best carried out before and after single-chamber PPM implantation. This study compares PPM placement in apical Right Ventricle (RV) and Right Ventricular Outflow Tract (RVOT) and compares paced QRS duration 150 ms and > 150 ms. Pacing burden >40% causes subclinical left ventricular systolic dysfunction after a month of PPM implantation with decreased GLS in apical RV pacing.This study gives additional information that PPM placement is preferably in RVOT with some specific settings. However, there are many ways to reduce the effects of impaired left ventricular function due to lead installation on the PPM single-chamber device. By using the PPM device which has a dual chamber, the leads will be placed in RVOT and also in the right atrium with atrial-ventricle synchronization. The aim is to avoid impaired left ventricular pump function as supported by a systematic review which states the superiority of dual-chamber PPM over single-chamber PPM in reducing atrial fibrillation and pacemaker syndrome. In the importance of quality of life related to heart disease, the Indonesian version of the MacNew questionnaire can be used. This questionnaire seeks the quality of life of patients with coronary heart disease after revascularization surgery and has undergone rehabilitation. Another important thing is the suitability of the adaptation to the original English version. |
cardiac patient; global longitudinal strain; MacNew questionnaire; pacemaker |
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NLM (Medline) |
01259326 |
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34611061 |
Article |
Q3 |
321 |
14162 |
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287 |
Lydia A., Priantono D., Harimurti K., Alwi I. |
8451287200;57219443427;23473513200;15055173800; |
The Relationship between Folic Acid and Vitamin B12 Serum Levels with High Sensitivity C-reactive Protein and Homocysteine in Chronic Hemodialysis Patients: A Cross-sectional Study |
2021 |
Acta medica Indonesiana |
53 |
3 |
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282 |
290 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117858308&partnerID=40&md5=30f4d1e6b0ba005c917362c78562ed5b |
Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo National HospitalJakarta, Indonesia |
Lydia, A., Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo National HospitalJakarta, Indonesia; Priantono, D.; Harimurti, K.; Alwi, I. |
BACKGROUND: Folic acid (FA) and vitamin B12 treatment have been routinely prescribed to lower serum homocysteine levels and to reduce inflammation. However, no study has been conducted to determine serum folic acid (SFA) and vitamin B12 (B12) levels in patients who have twice-weekly hemodialysis. The aim of our study was to assess serum folate and B12 levels in chronic hemodialysis patients and their relationship with hsCRP and homocysteine levels. METHODS: Our study was a cross-sectional study involcing patients who had twice-weekly hemodialysis in Dr Cipto Mangunkusumo National Hospital Jakarta, Indonesia. Predialysis blood samples were taken to measure SFA, B12, homocysteine and hsCRP levels. Patients with medical conditions affecting the assays were excluded. Spearman correlation was used to compare variables. RESULTS: Eighty subjects enrolled in this study. Among those of non-given folic acid and vitamin B-12 supplementation, only 3.85% of subjects had low folic acid levels, and none had low vitamin B12 levels. A moderate negative correlation between serum folic acid and homocysteine level (p≤0.001; r=-0.42) and a weak correlation between serum vitamin B12 and homocysteine level (p=0.009; r=-0.29) was found. Among the high-risk cardiovascular group (CRP>3, n=49), there is a moderate negative correlation between serum folic acid and homocysteine level (p≤0.001; r=-0.561) and a weak negative correlation between vitamin B12 and homocysteine level (p=0.018; r=-0.338). CONCLUSION: There is a significant negative correlation between serum vitamin B12 and folic acid with homocysteine levels, especially in high-risk cardiovascular group. |
cardiovascular; chronic hemodialysis; CKD; Folic acid; hsCRP; morbidity; mortality; vitamin B12 |
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NLM (Medline) |
01259326 |
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34611067 |
Article |
Q3 |
321 |
14162 |
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288 |
Atmakusuma T.D., Kalwani R., Nasution S.A., Rumende C.M. |
57216961785;57310670300;57189373134;14325966300; |
Correlation of Serum Ferritin and Cardiac Iron Toxicity with Cardiac Function in Transfusion Dependent Beta-Thalassemia Major Patients |
2021 |
Acta medica Indonesiana |
53 |
3 |
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291 |
298 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117853935&partnerID=40&md5=508f3a43041f0289262b56448c4ae575 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo HospitalJakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo HospitalJakarta, Indonesia; Kalwani, R.; Nasution, S.A.; Rumende, C.M. |
BACKGROUND: Cardiac iron toxicity is a major cause of mortality in transfusion-dependent beta-thalassemia major patients. The main modality for detecting cardiac iron toxicity is MRI T2* with limited availability. This study aims to obtain iron toxicity profiles in transfusion-dependent beta-thalassemia patients; to see a correlation between iron toxicity and cardiac function. METHODS: We conducted a cross-sectional study at the Adult Thalassemia Polyclinic of Cipto Mangunkusumo Hospital, Indonesia from December 2017 to March 2018. We performed the statistical analysis using Pearson/Spearman Test comparing MRI T2* values with ejection fraction and E/A ratio. RESULTS: The median of 4-months mean of ferritin levels was 5130 ng/mL. The mean for cardiac T2* was 24.96 ms. Severe cardiac hemosiderosis (mean cardiac MRI T2* < 10 ms) occurred in 11.3% of the subjects. There was weak correlation between serum ferritin with cardiac iron toxicity (r=-0.272, p=0.032) and ejection fraction (r=-0.281, p=0.013). But, there was no correlation between cardiac iron toxicity with ejection fraction and E/A ratio. CONCLUSION: Serum ferritin correlated weakly with cardiac iron toxicity and cardiac systolic function. Meanwhile, there was no correlation between cardiac iron toxicity with cardiac systolic and diastolic function. |
cardiac iron toxicity; cardiac MRI T2*; diastolic function; serum ferritin; systolic function |
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NLM (Medline) |
01259326 |
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34611068 |
Article |
Q3 |
321 |
14162 |
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289 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Bardosono S., Sungkar S., Rachmat J., Hediyati M., Silalahi T. |
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;21933841000;57016857300;6507225348;57310558800;56275255400; |
Wound Healing in Diabetic Foot Ulcer Patients Using Combined Use of Platelet Rich Fibrin and Hyaluronic Acid, Platelet Rich Fibrin and Placebo: An Open Label, Randomized Controlled Trial |
2021 |
Acta medica Indonesiana |
53 |
3 |
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268 |
275 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117847076&partnerID=40&md5=089bf13006cbe4a09ad0a915462eec3b |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Kartika, R.W., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Alwi, I.; Suyatna, F.D.; Yunir, E.; Waspadji, S.; Immanuel, S.; Bardosono, S.; Sungkar, S.; Rachmat, J.; Hediyati, M.; Silalahi, T. |
BACKGROUND: Autologous platelet-rich fibrin (A-PRF) is an adjunctive method for diabetic foot ulcer (DFU) in addition to glycaemic control and debridement. This study aimed to evaluate the role of A-PRF + hyaluronic acid (HA), A-PRF and sodium chloride 0.9% (control) in DFU wound healing. Nowaday, the use of PRF autologous consider as adjuvant therapy in DFU treatment. METHODS: This open-label randomized controlled trial was conducted at Koja District Hospital and Gatot Soebroto Hospital from July 2019 to April 2020. DFU patients with wound duration of three months, Wagner-2, and ulcer size < 40 cm2 were recruited and randomly assigned into A-PRF + AH, A-PRF and control group. On day-0, day-3 and day -7, samples and photographs were taken. Samples were analysed with ELISA and photographs were analysed with ImageJ to calculate granulation index (GI). Statistical analysis was performed using SPSS version 20. RESULTS: Topical therapy with A-PRF + AH was associated with a significant increase in VEGF from day 0 (232.8 pg/mg) vs day 7 (544.5 pg/mg) compared to A-PRF on day 0 (185.7 pg/mg) vs day 7 (272.8 pg/mg), and the controls on day 0 (183.7 pg/mg) vs day 7 (167.4 pg/mg). On evaluation of VEGF swab, there is increasing significantly in A-PRF+HA group compare others group in day -3 ( p=0.022) and day -7 (p= 0.001).In the A-PRF + AH group, there was a significant decrease in IL-6 from day 0 (106.4 pg/mg) vs day 7 (88.7 pg/mg) compared with PRF on day 0 (91.9 pg/mg) vs day 7 (48,8 pg/mg). IL-6 was increased in the control group from day 0 (125.3 pg/mg) vs day 7 (167.9 pg/mg). On evaluation of IL-6 swab, there is decreasing significantly in A-PRF+HA group compare others group in day -7 (p= 0.041). CONCLUSION: The PRF + HA combination increased angiogenesis and reduced inflammation in DFUs and may represent a new DFU therapy. |
diabetic foot ulcer; hyaluronic acid; platelet-rich fibrin |
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NLM (Medline) |
01259326 |
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34611065 |
Article |
Q3 |
321 |
14162 |
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290 |
Shatri H., Prabu O.G., Tetrasiwi E.N., Faisal E., Putranto R., Ismail R.I. |
28767986500;57194132172;57267704700;57218497073;56074051000;57311408800; |
The Role of Online Psychotherapy in COVID-19: An Evidence Based Clinical Review |
2021 |
Acta medica Indonesiana |
53 |
3 |
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352 |
359 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117834929&partnerID=40&md5=ace8f85c837d6a06647336cc35e3f051 |
Division of Psychosomatic and Palliative, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Shatri, H., Division of Psychosomatic and Palliative, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Prabu, O.G.; Tetrasiwi, E.N.; Faisal, E.; Putranto, R.; Ismail, R.I. |
BACKGROUND: COVID-19 is an infectious disease that is easily widespread and has clinical manifestations as mild, moderate, or severe disease. COVID-19 patients are required to be isolated during treatment to reduce transmission. This can cause anxiety and depression, which in turn worsens the patient's illness. Providing supportive psychotherapy can help provide a feeling of safety, comfort and calm for patients. The choice of method in providing supportive psychotherapy can be done online/teleconsultation or internet-based. This clinical review aims to determine the effect of online teleconsultation or internet-based psychotherapy on COVID-19 patients. METHODS: A systematic search was performed using online databases, such as PubMed, Cochrane, EBSCO/CINAHL and ProQuest. The identified articles were screened using eligibility criteria. There were 2 studies (Zhou et al, and Wei et al) which were analyzed critically using the Newcastle Ottawa Scale. RESULTS: Both studies showed that management of psychotherapy through teleconsultation or internet-based on COVID-19 patients can help relieve the patient's psychological symptoms. Zhou et al studied 63 suspected COVID-19 with 23.8% (n = 15) having a Hospital Anxiety Depression Scale (HADS) score of 8 or more. There was a significant decrease in HADS-A nxiety (HADS-A) scores (p <0.01) and HADS-Depression (HADS-D) scores (p <0.01) in 15 patients, and from the overall HADS scores (p < 0.01). Wei et al. Showed 17-HAMD and HAMA scores in the online psychological intervention group also showed a significant reduction in symptoms of depression and anxiety compared to controls. CONCLUSION: Psychotherapy through online teleconsultation or internet-based on COVID-19 patients can help relieve symptoms of anxiety and depression and teleconsultation and also effective in dealing with psychological complications in patients with COVID-19. |
anxiety; COVID-19; depression; online; teleconsultation |
anxiety; communicable disease control; depression; epidemiology; human; prevention and control; procedures; psychology; psychotherapy; teleconsultation; Anxiety; Communicable Disease Control; COVID-19; Depression; Humans; Internet-Based Intervention; Psychotherapy; Remote Consultation; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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34611077 |
Article |
Q3 |
321 |
14162 |
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