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No records
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921 |
Li S., Tarlac V., Christanto R.B.I., French S.L., Hamilton J.R. |
57211771149;6505711498;57218589212;56115043700;7403703575; |
Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902 |
2021 |
Platelets |
32 |
7 |
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988 |
991 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089693705&doi=10.1080%2f09537104.2020.1810654&partnerID=40&md5=3b941631d42818b3c0eeae356d7833eb |
Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Li, S., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Tarlac, V., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Christanto, R.B.I., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; French, S.L., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Hamilton, J.R., Australian Centre for Blood Diseases, Monash University, Melbourne, Australia |
The thrombin receptor, protease-activated receptor 4 (PAR4), is important for platelet activation and is the target of emerging anti-thrombotic drugs. A frequently occurring single nucleotide polymorphism (SNP; rs773902) causes a function-altering PAR4 sequence variant (NC_000019.10:p.Ala120Thr), whereby platelets from Thr120-expressing individuals are hyper-responsive to PAR4 agonists and hypo-responsive to some PAR4 antagonists than platelets from Ala120-expressing individuals. This altered pharmacology may impact PAR4 inhibitor development, yet the underlying mechanism(s) remain unknown. We tested whether PAR4 surface expression contributes to the altered receptor function. Quantitative flow cytometry was used to determine the absolute number of PAR4 on platelets from individuals subsequently genotyped at rs773902. We detected 539 ± 311 PAR4 per platelet (mean ± SD, n = 84). This number was not different across rs773902 genotypes. This first determination of cellular PAR4 numbers indicates variations in platelet surface expression do not explain the altered pharmacology of the rs773902 PAR4 sequence variant. © 2020 Taylor & Francis Group, LLC. |
Platelets; protease-activated receptors; thrombin |
proteinase activated receptor 4; protease-activated receptor 4; thrombin receptor; adult; Article; cell surface; controlled study; flow cytometry; genetic association; genotype; human; human cell; protein expression; quantitative analysis; sequence analysis; single nucleotide polymorphism; thrombocyte activation; thrombocyte membrane; blood; metabolism; single nucleotide polymorphism; thrombocyte; Blood Platelets; Humans; Polymorphism, Single Nucleotide; Receptors, Thrombin |
Taylor and Francis Ltd. |
09537104 |
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32819173 |
Article |
Q2 |
939 |
4803 |
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922 |
Aman A.T., Wibawa T., Kosasih H., Asdie R.H., Safitri I., Intansari U.S., Mawarti Y., Sudarmono P., Arif M., Puspitasari D., Alisjahbana B., Parwati K.T.M., Gasem M.H., Lokida D., Lukman N., Hartono T.S., Mardian Y., Liang C.J., Siddiqui S., Karyana M., Lau C.-Y. |
6701594071;6507271804;6507043017;23494913500;26647011700;55326687600;57194392139;6507855437;56740206600;37001098000;6506944516;57211545843;6508371601;57190663838;57190737414;57210165041;57196189278;57201642191;8707129300;24449083500;16245242000; |
Etiologies of severe acute respiratory infection (SARI) and misdiagnosis of influenza in Indonesia, 2013-2016 |
2021 |
Influenza and other Respiratory Viruses |
15 |
1 |
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34 |
44 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087868865&doi=10.1111%2firv.12781&partnerID=40&md5=d277f265cec13ab0a49fac5153d6d8ed |
Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Hasanudin / Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; Dr. Soetomo Academic General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Faculty of Medicine, Universitas Padjadjaran / Dr. Hasan Sadikin Hospital, Sumedang, Indonesia; Medical Faculty, Udayana University and Sanglah General Hospital, Denpasar, Indonesia; Dr. Kariadi Hospital / Diponegoro University, Semarang, Indonesia; Tangerang District Hospital, Tangerang, Indonesia; Sulianti Saroso Hospital, Jakarta, Indonesia; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, United States; National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia |
Aman, A.T., Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia, Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Wibawa, T., Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia, Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Kosasih, H., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Asdie, R.H., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Safitri, I., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, Department of Pediatric, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Intansari, U.S., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, Department of Clinical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Mawarti, Y., Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia, Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Sudarmono, P., Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arif, M., Faculty of Medicine, Universitas Hasanudin / Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; Puspitasari, D., Dr. Soetomo Academic General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Alisjahbana, B., Faculty of Medicine, Universitas Padjadjaran / Dr. Hasan Sadikin Hospital, Sumedang, Indonesia; Parwati, K.T.M., Medical Faculty, Udayana University and Sanglah General Hospital, Denpasar, Indonesia; Gasem, M.H., Dr. Kariadi Hospital / Diponegoro University, Semarang, Indonesia; Lokida, D., Tangerang District Hospital, Tangerang, Indonesia; Lukman, N., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Hartono, T.S., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, Sulianti Saroso Hospital, Jakarta, Indonesia; Mardian, Y., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Liang, C.J., National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, United States; Siddiqui, S., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, United States; Karyana, M., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia; Lau, C.-Y., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, United States |
Background: Severe acute respiratory infection (SARI) accounts for a large burden of illness in Indonesia. However, epidemiology of SARI in tertiary hospitals in Indonesia is unknown. This study sought to assess the burden, clinical characteristics, and etiologies of SARI and concordance of clinical diagnosis with confirmed etiology. Methods: Data and samples were collected from subjects presenting with SARI as part of the acute febrile Illness requiring hospitalization study (AFIRE). In tertiary hospitals, clinical diagnosis was ascertained from chart review. Samples were analyzed to determine the “true” etiology of SARI at hospitals and Indonesia Research Partnership on Infectious Diseases (INA-RESPOND) laboratory. Distribution and characteristics of SARI by true etiology and accuracy of clinical diagnosis were assessed. Results: Four hundred and twenty of 1464 AFIRE subjects presented with SARI; etiology was identified in 242 (57.6%), including 121 (28.8%) viruses and bacteria associated with systemic infections, 70 (16.7%) respiratory bacteria and viruses other than influenza virus, and 51 (12.1%) influenza virus cases. None of these influenza patients were accurately diagnosed as having influenza during hospitalization. Conclusions: Influenza was misdiagnosed among all patients presenting with SARI to Indonesian tertiary hospitals in the AFIRE study. Diagnostic approaches and empiric management should be guided by known epidemiology. Public health strategies to address the high burden of influenza should include broad implementation of SARI screening, vaccination programs, clinician education and awareness campaigns, improved diagnostic capacity, and support for effective point-of-care tests. © 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. |
diagnostic accuracy; etiology; Indonesia; influenza; severe acute respiratory infection |
adolescent; adult; Article; child; demography; diagnostic accuracy; diagnostic error; disease burden; female; hospitalization; human; Indonesia; influenza; information processing; major clinical study; male; measurement accuracy; medical record review; middle aged; priority journal; severe acute respiratory syndrome; tertiary care center; diagnostic error; infant; influenza; Orthomyxoviridae; respiratory tract infection; Diagnostic Errors; Hospitalization; Humans; Indonesia; Infant; Influenza, Human; Orthomyxoviridae; Respiratory Tract Infections |
Blackwell Publishing Ltd |
17502640 |
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32666619 |
Article |
Q1 |
1743 |
1724 |
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923 |
Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. |
57200542624;57217291921;55533574600;6504507193; |
Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates |
2021 |
Pediatric Nephrology |
36 |
1 |
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181 |
186 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087002032&doi=10.1007%2fs00467-020-04668-3&partnerID=40&md5=45ca525dfa7a5bd6f6f0c1d995fe7930 |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Hidayati, E.L., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Utami, M.D., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rohsiswatmo, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tridjaja, B., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Acute kidney injury (AKI) is one of the most common causes of neonatal morbidity and mortality. Diagnosing AKI in neonates is challenging as it lacks specific signs, symptoms, and biomarkers. However, detecting AKI in critically ill neonates is crucial to determine appropriate management and prevent complications. Cystatin C (CysC) has been recognized as a superior kidney biomarker reflecting kidney function in neonates. The objective of this study is to evaluate the diagnostic value of CysC as an AKI biomarker in critically ill neonates. Methods: We performed a diagnostic test between cystatin C-based estimated glomerular filtration rate (eGFR-CysC) and serum creatinine-based estimated glomerular filtration rate (eGFR-SCr) as the gold standard to diagnose AKI in 135 critically ill neonates treated in Cipto Mangunkusumo National Hospital from July 2017 to January 2018. Results: Prevalence of AKI was 23.7% predominantly in neonates with a very preterm gestational age, low birthweight, probable sepsis, and those receiving invasive oxygen therapy or nephrotoxic drugs. The proportion of AKI based on neonate RIFLE criteria was 72.7% risk, 18.9% injury, and 9% failure. eGFR-CysC had the following parameters: sensitivity, 84.8%; specificity, 61.8%; PPV, 41.8%; NPV, 89.7%; LR(+), 2.2; LR(−), 0.24; and accuracy, 67.4%. The AUROC for CysC was 84.9%. The optimal cut-off value for CysC was 1.605 mg/l. Conclusions: CysC may be used as a screening biomarker of AKI in critically ill neonates; yet, it was not superior to serum creatinine. [Figure not available: see fulltext.]. © 2020, IPNA. |
Acute kidney injury; Critically ill neonates; Cystatin C; Serum creatinine |
creatinine; cystatin C; biological marker; creatinine; cystatin C; epidermal growth factor receptor; acute kidney failure; area under the curve; Article; controlled study; creatinine blood level; critically ill patient; diagnostic accuracy; diagnostic test; diagnostic test accuracy study; diagnostic value; estimated glomerular filtration rate; extremely low birth weight; female; gestational age; human; low birth weight; major clinical study; male; negative likelihood ratio; newborn; oxygen therapy; positive likelihood ratio; predictive value; prematurity; prevalence; priority journal; receiver operating characteristic; sensitivity and specificity; sepsis; very low birth weight; acute kidney failure; critical illness; prospective study; Acute Kidney Injury; Biomarkers; Creatinine; Critical |
Springer Science and Business Media Deutschland GmbH |
0931041X |
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32594242 |
Article |
Q1 |
831 |
5739 |
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924 |
Alatas F.S., Matsuura T., Yoshimaru K., Kadim M., Taguchi T. |
57217150164;8666654700;42662821300;26644177600;35428570900; |
Alopecia in Children Following Living Related Liver Transplantation |
2021 |
Transplantation Proceedings |
53 |
1 |
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228 |
232 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086940620&doi=10.1016%2fj.transproceed.2020.05.020&partnerID=40&md5=c7023ec7a8f0d0564c7270be5ab42f43 |
Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Alatas, F.S., Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Matsuura, T., Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Yoshimaru, K., Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Kadim, M., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Taguchi, T., Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan |
Introduction: Alopecia is a common complication in patients following kidney transplantation; however, reports regarding liver transplantation patients are still few. Methods: This study followed 111 children who underwent living related liver transplantation. Alopecia patients and its possible risk factors were analyzed. Results: Alopecia occurred in 3 patients (2.7%). Underlying diseases were biliary atresia and Alagille syndrome. Clinically significant alopecia (universal alopecia) occurred in 1 patient with Alagille syndrome. All patients received tacrolimus as their immunosuppression drug. None of the patients who received cyclosporine experienced alopecia. The onset of alopecia ranged from 7 to 28 months after transplantation. Alopecia was treated with a topical corticosteroid and topical tacrolimus, but 1 patient with clinically severe alopecia required conversion from tacrolimus to cyclosporine A. Conclusions: Alopecia is 1 complication seen in children receiving tacrolimus therapy following living donor liver transplant. Prompt management of this cosmetic complication should be done to ensure patients’ compliance to medication regimen. © 2020 Elsevier Inc. |
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corticosteroid; cyclosporine; methylprednisolone; mycophenolate mofetil; prednisolone; tacrolimus; thymocyte antibody; cyclosporine; immunosuppressive agent; tacrolimus; acute graft rejection; Alagille syndrome; alopecia; Article; bile duct atresia; case report; child; clinical article; comorbidity; female; human; immunosuppressive treatment; liver transplantation; living related donor; male; medication compliance; pediatric patient; risk assessment; risk factor; treatment withdrawal; adverse event; alopecia; immunocompromised patient; immunology; infant; living donor; preschool child; Alopecia; Child, Preschool; Cyclosporine; Female; Humans; Immunocompromised Host; Immunosuppression; Immunosuppressive Agents; Infant; Liver Transplantation; Living Donors; Male; Tacrolimus |
Elsevier Inc. |
00411345 |
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32605770 |
Article |
Q3 |
373 |
12773 |
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925 |
Surja S.S., Adawiyah R., Houbraken J., Rozaliyani A., Sjam R., Yunihastuti E., Wahyuningsih R. |
57209258108;57208658742;12770401000;57203065912;23398458200;57221273925;6507268400; |
Talaromyces atroroseus in HIV and non-HIV patient: A first report from Indonesia |
2021 |
Medical Mycology |
58 |
4 |
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560 |
563 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085715396&doi=10.1093%2fMMY%2fMYZ090&partnerID=40&md5=9fec23d3506804c0bc622f42e14314ff |
Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Westerdijk Fungal Biodiversity Institute, Netherlands; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Parasitology, School of Medicine and Health Sciences, Universitas Katolik Indonesia, Atma Jaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Surja, S.S., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Parasitology, School of Medicine and Health Sciences, Universitas Katolik Indonesia, Atma Jaya, Indonesia; Adawiyah, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Houbraken, J., Westerdijk Fungal Biodiversity Institute, Netherlands; Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Sjam, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Yunihastuti, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Wahyuningsih, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia |
We performed morphology, molecular study and antifungal susceptibility test on 10 Talaromyces sp. isolates: eight clinical isolates (human immunodeficiency virus (HIV) and non-HIV-patient) and two isolates from rats. All strains produced red soluble pigment and microscopically showed Penicillium-like structure in room temperature and yeast-like structure in 37â—¦C. Based on molecular analysis, nine isolates were identified as Talaromyces atroroseus (including the isolates from rats) and one as T. marneffei. Our susceptibility result of T. marneffei supports the use of amphotericin B, itraconazole for talaromycosis marneffei management. Talaromyces atroroseus showed variable MIC to echinocandin, azole derivatives, 5-flucytosine and amphotericin B. © The Author(s) 2019. |
BenA; Indonesia; ITS; Talaromyces atroroseus; Talaromyces marneffei |
amphotericin B; anidulafungin; caspofungin; echinocandin; fluconazole; flucytosine; itraconazole; micafungin; posaconazole; pyrrole derivative; voriconazole; antifungal agent; antifungal susceptibility; Article; fungus isolation; human; Human immunodeficiency virus infected patient; Indonesia; mycosis; nonhuman; room temperature; Talaromyces; Talaromyces atroroseus; Talaromyces marneffei; talaromycosis; animal; classification; drug effect; genetics; Human immunodeficiency virus infection; Indonesia; isolation and purification; microbial sensitivity test; microbiology; pigmentation; rat; Talaromyces; Animals; Antifungal Agents; HIV Infections; Humans; Indonesia; Microbial Sensitivity Tests; Mycoses; Pigmentation; Rats; Talaromyces |
Oxford University Press |
13693786 |
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31504774 |
Article |
Q1 |
1004 |
4362 |
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926 |
Pranata R., Tondas A.E., Yonas E., Vania R., Yamin M., Chandra A., Siswanto B.B. |
57201973901;57211111907;57201987097;57208328436;23475706300;37025699200;14422648800; |
Differences in clinical characteristics and outcome of de novo heart failure compared to acutely decompensated chronic heart failure–systematic review and meta-analysis |
2021 |
Acta Cardiologica |
76 |
4 |
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410 |
420 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083567065&doi=10.1080%2f00015385.2020.1747178&partnerID=40&md5=e965cfa89cbc748fb0b3f9ae692b173b |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Sriwijaya, Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, United States; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Tondas, A.E., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Sriwijaya, Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yamin, M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Chandra, A., Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, United States; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Background: Recent evidence showed that the characteristics and outcome of those with de novo heart failure (HF) and acutely decompensated chronic heart failure (ADCHF) were different. We aimed to perform a comprehensive search on the clinical characteristics and outcome of patients with de novo HF and ADCHF. Methods: We performed a comprehensive search on de novo/new onset acute HF vs ADCHF from inception up until December 2019. Results: There were 38320 patients from 15 studies. De novo HF were younger and, had less prevalent hypertension, diabetes mellitus, ischaemic heart disease, chronic obstructive pulmonary disease, atrial fibrillation, and history of stroke/transient ischaemic attack compared to ADCHF. Five studies showed a lower NT-proBNP in de novo HF patients, while one study showed no difference. Valvular heart disease as aetiology of heart failure was less frequent in de novo HF, and upon sensitivity analysis, hypertensive heart disease was more frequent in de novo HF. As for precipitating factors, ACS (OR 2.42; I2:89%) was more frequently seen in de novo HF, whereas infection was less frequently (OR 0.69; I2:32%) in ADCHF. De novo HF was associated with a significantly lower 3-month mortality (OR 0.63; I2:91%) and 1-year (OR 0.59; I2:59%) mortality. Meta-regression showed that 1-year mortality did not significantly vary with age (p =.106), baseline ejection fraction (p =.703), or HF reduced ejection fraction (p =.262). Conclusion: Risk factors, aetiology, and precipitating factors of HF in de novo and ADCHF differ. De novo HF also had lower 1-year mortality and 3-month mortality compared to ADCHF. © 2020 Belgian Society of Cardiology. |
acute decompensated heart failure; acute heart failure; characteristics; De novo heart failure; mortality; new onset heart failure |
amino terminal pro brain natriuretic peptide; creatinine; hemoglobin; acute coronary syndrome; acutely decompensated chronic heart failure; Article; atrial fibrillation; cardiovascular infection; cardiovascular mortality; cerebrovascular accident; Charlson Comorbidity Index; chronic obstructive lung disease; clinical feature; clinical outcome; coronary artery disease; de novo heart failure; diabetes mellitus; estimated glomerular filtration rate; heart arrhythmia; heart ejection fraction; heart failure; heart failure with reduced ejection fraction; hospital mortality; human; hypertension; ischemic heart disease; meta analysis; mortality rate; prevalence; risk factor; sensitivity analysis; smoking; systematic review; transient ischemic attack; valvular heart disease |
Taylor and Francis Ltd. |
00015385 |
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32252602 |
Article |
Q3 |
348 |
13410 |
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