No records
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143 |
Djaali W., Mihardja H., Viventius Y., Teja Y., Bunawan H.L., Setiawan M., Yunita L. |
57212479564;57195721818;57223088537;57325017200;57324454000;57324269700;57324454100; |
The Role of Acupuncture in Interventional Pain Management |
2021 |
Medical Acupuncture |
33 |
5 |
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329 |
334 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118530798&doi=10.1089%2facu.2021.0004&partnerID=40&md5=7d65d90740d49223d9332a2572c084c0 |
Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Negeri Jakarta, East Jakarta, DKI Jakarta, Indonesia; Center for the Development and Application of Traditional Medicine of DKI Jakarta, Jakarta, Indonesia |
Djaali, W., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Negeri Jakarta, East Jakarta, DKI Jakarta, Indonesia; Mihardja, H., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Center for the Development and Application of Traditional Medicine of DKI Jakarta, Jakarta, Indonesia; Viventius, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Teja, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bunawan, H.L., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, M., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yunita, L., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Interventional pain management has been recognized over the last couple of decades for treating chronic-pain syndromes. Acupuncture is a nonpharmacologic therapeutic option for pain management and may be an option for different patients with contraindications for interventional pain management. This review explores this options. Method: This limited review examines the role of acupuncture for managing head-and-neck pain and lower-back pain, according to interventional pain management. Conclusions: Acupuncture at various points, corresponding to the stellate ganglion, which is ST 10 Shuitu, and corresponding to the splanchnic nerve and the facet joint of the lumbar vertebra - which are Ex-B2 paravertebra - can be applied for pain management in the head-and-neck area and in the lower-back area. According to various research findings, acupuncture is effective and safe for reducing pain in the head and neck area, as well as in the lower back. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
acupuncture; head-and-neck pain; interventional pain management; lower-back pain |
acupuncture analgesia; headache; human; interventional pain management; intervertebral articulation; low back pain; neck pain; nerve block; neuroanatomy; paraspinal muscle; Review; shuitu acupoint; splanchnic nerve; stellate ganglion; stellate ganglion block |
Mary Ann Liebert Inc. |
19336586 |
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Review |
Q2 |
281 |
15498 |
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145 |
Hansur L., Pawitan J.A. |
57296411600;6508348067; |
The potential of hydroxysafflor yellow a as an adjuvant in covid-19 patients with acute respiratory distress syndrome |
2021 |
International Medical Journal |
28 |
5 |
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527 |
531 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117118067&partnerID=40&md5=caa56a92d25ef57cc5e5c3533887adf1 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Makassar, Makassar, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Hansur, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Muhammadiyah Makassar, Makassar, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To discuss the potential and molecular mechanism of Carthamus tincorius derived hydroxysafflor yellow A (HSYA) as an alternative herbal adjuvant that may regulate various signaling pathways that might be related to the regulatory effects in COVID-19 patients with ALI and ARDS. Methods: We search Web of Science, PubMed, and Scopus using keywords: Carthamus tinctorius, adjuvant, cytokine storm, COVID-19, SARS-Cov-2, acute lung injury (ALI), and Acute Respiratory Distress Syndrome (ARDS), on 11 September 2020, and 18 December 2020. Results and Discussions: In COVID-19 patients, SARS-CoV-2 replication might be associated with hyper induction of pro-in-flammatory cytokine, which is known as a cytokine storm, and may cause acute lung injury (ALI) that leads to Acute Respiratory Distress Syndrome (ARDS). Carthamus tincorius derived HSYA were used in many studies, in vivo in animal models or in vitro in cell lines and showed inhibition of multiple inflammatory pathways that were involved in ALI and ARDS, which might occur in covid-19 patients. HSYA showed pleiotropic effects in regulating cytokine levels. It regulated TNF-α, IL-1β, IL-6, IFN-β, and showed protective effect by blocking TLR4, MyD88, TRIF, IRF3, NF-κB to avoid cytokine storm and prevent tissue damage. HSYA was showed to reduce oxidative stress-mediated damage, and down-regulate inflammatory cytokines. Further, it was relatively safe when studied as an adjuvant in HIV and cancer patients. Conclusion: We supposed that HSYA could be used as an alternative adjuvant in COVID-19 patients with ARDS. However, clinical trials are needed to prove its efficacy in COVID-19 patients with ARDS. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Carthamus tinctorius; COVID-19; Cytokine storm; HSYA; SARS-Cov-2 |
adjuvant; curcumin; hydroxysafflor yellow a; interleukin 1beta; interleukin 6; interleukin 8; myeloid differentiation factor 88; natural product; pathogen associated molecular pattern; toll like receptor 4; tumor necrosis factor; unclassified drug; acute lung injury; adult respiratory distress syndrome; antiinflammatory activity; apoptosis; Article; binding affinity; brain ischemia; cancer patient; coronavirus disease 2019; cytokine production; cytokine storm; down regulation; dyspnea; endothelial dysfunction; endothelium cell; enzyme activity; human; Human immunodeficiency virus; immune response; inflammation; lung edema; nonhuman; pleiotropy; protein expression; protein function; reperfusion injury; respiratory failure; Severe acute respiratory syndrome coronavirus 2; signal transduction |
Japan International Cultural Exchange Foundation |
13412051 |
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Article |
Q4 |
183 |
20490 |
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146 |
Dwijayanti A., Pawitan J.A. |
55743787900;6508348067; |
Mesenchymal stem cell aging, their environment and methods to restore their quality |
2021 |
International Medical Journal |
28 |
5 |
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520 |
523 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117117062&partnerID=40&md5=e4cc00f4efb942f9321160eff1b790a8 |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dwijayanti, A., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: This article aims to explore the aging of mesenchymal stem cells (MSCs) during cell expansion and available methods to restore their quality. Materials and methods: we searched articles in PubMed/Medline and our library to collect relevant publications of MSC aging, their microenvironment (niche), and various approaches to prevent MSC aging. Results and Discussion: MSC expansion during culture may cause cell aging, which is reflected by change in growth, geno-type, and phenotype that can be seen in morphology and function. There are various approaches that can be used to prevent MSC aging. Approaches to prevent MSC aging in culture can be done by various methods, including by determining donor characteristics, genetic engineering approaches, regulating stem cells microenvironment in vitro, and in vitro physical modification Conclusion: Prevention of MSC aging during culture can be done by selection of MSC sources, genetic modification, and microenvironment and physical adjustments. ©2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Aging; Cell culture; Mesenchymal stem cells; Micro environment; Propagation |
adult; article; cell aging; cell culture; DNA modification; genetic engineering; human; human cell; Medline; mesenchymal stem cell; microenvironment; phenotype; stem cell expansion |
Japan International Cultural Exchange Foundation |
13412051 |
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Article |
Q4 |
183 |
20490 |
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147 |
Merati T.P., Karyana M., Tjitra E., Kosasih H., Aman A.T., Alisjahbana B., Lokida D., Arlinda D., Maldarelli F., Neal A., Arif M., Gasem M.H., Lukman N., Sudarmono P., Lau C.-Y., Hadi U., Lisdawati V., Wulan W.N., Lane H.C., Siddiqui S. |
57203678680;24449083500;57204151009;6507043017;6701594071;6506944516;57190663838;57218444330;57210198407;57220466230;56740206600;6508371601;57190737414;6507855437;16245242000;55804160500;56786334300;57204491118;57197596240;8707129300; |
Prevalence of HIV infection and resistance mutations in patients hospitalized for febrile illness in Indonesia |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
4 |
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960 |
965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117017901&doi=10.4269%2fajtmh.20-1595&partnerID=40&md5=f52639e32eebbadb71cd505b119b26d4 |
Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia; Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia; National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia; Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia; Indonesia Research Partnership on Infections Disease, Jalan Percetakan Negara No. 29, Jakarta, 10560, Indonesia |
Merati, T.P., Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Karyana, M., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia, Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Tjitra, E., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia; Kosasih, H., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia, Indonesia Research Partnership on Infections Disease, Jalan Percetakan Negara No. 29, Jakarta, 10560, Indonesia; Aman, A.T., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Alisjahbana, B., Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Lokida, D., Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia; Arlinda, D., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia, Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Maldarelli, F., National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Neal, A., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Arif, M., Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia; Gasem, M.H., Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Lukman, N., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Sudarmono, P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lau, C.-Y., National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Hadi, U., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Lisdawati, V., Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia; Wulan, W.N., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Lane, H.C., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Siddiqui, S., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States |
HIV prevalence in Indonesia is increasing, and only 64% of infected individuals know their status. In a prospective cohort of 1,453 hospitalized patients with unexplained fever, 46 (3.2%) had HIV, including 15 (1.1%) patients without a prior HIV diagnosis. Among 31 subjects previously known to have HIV, 21 (68%) had been receiving combination antiretroviral therapy (cART) at the time of enrollment. Of 39 HIV cases with HIV RNA levels $ 100 copies/mL, sequencing for genotype analysis and resistance testing was successful in 30 (77%) subjects. The most common HIV subtypes were AE (90%) and B (10%). Five (16.7%) subjects had resistance mutations to nucleoside and non-nucleoside reverse transcriptase inhibitors, and all of them were on cART. No evidence of transmitted drug resistance was found in newly diagnosed individuals. Hospital-based screening may be an efficient method to expand HIV testing and identify a significant number of new cases. Access to care, close monitoring, expansion of anti-retroviral options, and ensuring availability of CD4 determinations, viral load testing, and genotyping are crucial to control of the epidemic in Indonesia. © 2021 by The American Society of Tropical Medicine and Hygiene |
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nonnucleoside reverse transcriptase inhibitor; RNA directed DNA polymerase inhibitor; virus RNA; anti human immunodeficiency virus agent; adolescent; adult; aged; antiretroviral therapy; Article; child; cohort analysis; combination drug therapy; female; fever; genotype; hospital patient; hospitalization; human; Human immunodeficiency virus infection; Indonesia; major clinical study; male; nonhuman; prevalence; prospective study; virus mutation; virus resistance; antiviral resistance; drug effect; genetics; Human immunodeficiency virus 1; Human immunodeficiency virus infection; infant; middle aged; mutation; preschool child; very elderly; virology; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Child; Child, Preschool; Drug Resistance, Viral; Female; HIV Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
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34460416 |
Article |
Q1 |
1015 |
4298 |
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152 |
Oswari H., Alatas F.S., Hegar B., Cheng W., Pramadyani A., Benninga M.A., Rajindrajith S. |
12777323800;57217150164;6506273944;57204068621;57204063138;7003532912;23475357200; |
Aerophagia Study in Indonesia: Prevalence and Association with Family-related Stress |
2021 |
Journal of Clinical Gastroenterology |
55 |
9 |
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772 |
777 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115434505&doi=10.1097%2fMCG.0000000000001434&partnerID=40&md5=6e63f2b47973c55f30df2a8a6c98489f |
Department of Child Health, Gastrohepatology Division, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Paediatric Gastroenterology and Nutrition, Emma children'S, Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands; Department of Paediatrics, University of Colombo, Colombo, Sri Lanka |
Oswari, H., Department of Child Health, Gastrohepatology Division, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Alatas, F.S., Department of Child Health, Gastrohepatology Division, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Hegar, B., Department of Child Health, Gastrohepatology Division, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Cheng, W., Department of Child Health, Gastrohepatology Division, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pramadyani, A., Department of Child Health, Gastrohepatology Division, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Benninga, M.A., Department of Paediatric Gastroenterology and Nutrition, Emma children'S, Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands; Rajindrajith, S., Department of Paediatrics, University of Colombo, Colombo, Sri Lanka |
Background: Aerophagia is a functional gastrointestinal disorder characterized by repeated air swallowing leading to chronic abdominal distension. Symptoms can be long lasting, lead to frustration, and distress. This study describes prevalence, related factors, and symptomatology of aerophagia, together with its relationship with emotional stress. Materials and Methods: Cross-sectional study. Adolescents aged 10 to 17 years from selected state schools by convenient sampling from Jakarta, Indonesia, were recruited. Rome III self-administered questionnaire was used to compile data on gastrointestinal symptoms. Data on sociodemographic characteristics, intestinal and extraintestinal symptoms, and stressful life events were collected using a separate questionnaire. Results: A total of 1796 questionnaires were included in the analysis [males 732 (40.8%), mean age 13.58 (SD 0.992) years]. There were 81 (4.5%) subjects diagnosed with aerophagia. When the criterion of belching was removed from the diagnosis of aerophagia, the prevalence drops to only 2 (0.1%). subjects. Bivariate analysis showed that sociodemographic factors have no correlation with aerophagia. In subjects with aerophagia, among the intestinal-related and extraintestinal symptoms, only loss of appetite was significantly more common in the aerophagia population (33.3%) when compared with controls (22.8%). Death of a close family member [adjusted odds ratio (OR), 2.78; 95% confidence interval (CI), 1.46-5.31; P=0.002], divorce or separation of parents (adjusted OR, 2.54; 95% CI, 1.38-4.66; P=0.003), and divorce followed by separate individual remarriage of parents (adjusted OR, 2.01; 95% CI, 1.01-3.98; P=0.046) were found to be significantly associated with aerophagia by multivariate analysis. Conclusions: The prevalence of aerophagia was found in 4.5% of Indonesian school-aged children according to Rome III criteria, but the prevalence was found only 0.1% if the belching is removed from the criteria. Besides the main symptoms, only loss of appetite was significantly more common in aerophagia among intestinal-related and extraintestinal symptoms. Family-related stress showed a significant correlation with aerophagia. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
adolescent; aerophagia; emotional stress; loss of appetite |
abdominal distension; abdominal pain; adolescent; aerophagia; air; Article; bivariate analysis; child; clinical feature; constipation; controlled study; cross-sectional study; death; demography; divorce; dizziness; emotional stress; eructation; family; family stress; female; fever; flatulence; gastrointestinal symptom; headache; human; Indonesia; life event; limb pain; loss of appetite; major clinical study; male; nausea; photophobia; prevalence; questionnaire; sampling; school; sensitivity analysis; separated parent; swallowing; vomiting; anxiety; Indonesia; Adolescent; Aerophagy; Anxiety; Child; Cross-Sectional Studies; Humans; Indonesia; Male; Prevalence; Surveys and Questionnaires |
Lippincott Williams and Wilkins |
01920790 |
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33009193 |
Article |
Q2 |
1141 |
3580 |
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155 |
Blom I.M., Campos L.N., El Amine Youcef Ali M., Asyura M.M.A.Z., von Metnitz D.Z., Limann B., JanušonytÄ— E. |
57218125715;57256325100;57257173900;57256325200;57257174000;57257030900;57211896142; |
Youth versus pandemics: the role of future generations in the pandemic treaty |
2021 |
The Lancet Global Health |
9 |
10 |
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e1361 |
e1362 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114832726&doi=10.1016%2fS2214-109X%2821%2900307-7&partnerID=40&md5=8425b6166dd6fbd88fa21d99ef4c5772 |
International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark; University of Amsterdam, Amsterdam, Netherlands; Faculty of Medical Sciences, Universidade de Pernambuco, Recife, Brazil; Faculty of Medicine, University of Constantine 3, Constantine, Algeria; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sigmund Freud University Vienna, Vienna, Austria; University of Ghana Medical School, Accra, Ghana; Faculty of Medicine, Vilnius University, Vilnius, Lithuania |
Blom, I.M., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, University of Amsterdam, Amsterdam, Netherlands; Campos, L.N., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Faculty of Medical Sciences, Universidade de Pernambuco, Recife, Brazil; El Amine Youcef Ali, M., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Faculty of Medicine, University of Constantine 3, Constantine, Algeria; Asyura, M.M.A.Z., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; von Metnitz, D.Z., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Sigmund Freud University Vienna, Vienna, Austria; Limann, B., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, University of Ghana Medical School, Accra, Ghana; JanušonytÄ—, E., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Faculty of Medicine, Vilnius University, Vilnius, Lithuania |
[No abstract available] |
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awareness; government; health care organization; health care policy; human; leadership; Note; pandemic; public health; work environment; adult; disaster planning; female; global health; legislation and jurisprudence; male; organization and management; pandemic; social responsibility; World Health Organization; young adult; Adult; Disaster Planning; Female; Global Health; Humans; Male; Pandemics; Social Responsibility; World Health Organization; Young Adult |
Elsevier Ltd |
2214109X |
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34331865 |
Note |
Q1 |
7970 |
126 |
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156 |
Yoanita R., Gunardi H., Rohsiswatmo R., Setyanto D.B. |
57257403000;56510252700;55533574600;57203009929; |
Effect of tactile–kinesthetic stimulation on growth, neurobehavior and development among preterm neonates |
2021 |
Journal of Bodywork and Movement Therapies |
28 |
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180 |
186 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114826873&doi=10.1016%2fj.jbmt.2021.06.023&partnerID=40&md5=42e65f10f1f437b31aaa9dd4fdb3559e |
Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Developmental Behavioural & Community Pediatrics Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Neonatology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Pediatric Respirology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Yoanita, R., Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Gunardi, H., Developmental Behavioural & Community Pediatrics Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Setyanto, D.B., Pediatric Respirology Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Background: Preterm neonates are at risk of delayed growth and development. Hence, early tactile–kinesthetic stimulation (TKS) is required to improve their growth and development. Objective: To evaluate the effect of TKS on growth, neurobehavior and development among preterm neonates. Method: An interventional study was conducted from August 2015 to July 2017 in the neonatal unit of Dr. Cipto Mangunkusumo Hospital. Preterm neonates were recruited via random sampling and divided into two groups (the intervention group and control group). TKS was performed for 15 min, three times a day, for 10 days. The anthropometric measurements, neurobehavior (Dubowitz score) and development (Capute Scale score) of neonates in both groups were assessed. Results: There were 126 preterm neonates (n = 63 in each group). During the 10-day TKS period, the intervention group had a significant increment in weight and length compared to the control group (p < 0.05) at 11–14 days, at term and 3 months. Moreover, increased tone, reflexes, and improvement in behavior based on the Dubowitz score were observed during monitoring. However, the result did not differ significantly (p > 0.05). There was no significant difference in terms of cognitive and language development in both groups (Developmental Quotient of Clinical Linguistic Adaptive Milestone Scale, Developmental Quotient of Clinical Adaptive Test and Full Scale Developmental Quotient scores, p > 0.05). Conclusion: TKS was significantly effective in promoting growth, particularly weight and length, among preterm neonates. However, it did not significantly influence neurobehavior and development at 3 months of chronological age. © 2021 Elsevier Ltd |
Growth; Infant behavior; Infant development; Preterm infants; Tactile perception |
human; kinesthesia; newborn; prematurity; touch; Humans; Infant, Newborn; Infant, Premature; Kinesthesis; Touch |
Churchill Livingstone |
13608592 |
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34776139 |
Article |
Q1 |
467 |
10672 |
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160 |
Yulian E.D., Siregar N.C., Bajuadji |
55983956600;6508087790;57318007000; |
Combination of Simvastatin and FAC Improves Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer |
2021 |
Cancer Research and Treatment |
53 |
4 |
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1072 |
1083 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111269220&doi=10.4143%2fcrt.2020.1024&partnerID=40&md5=fe14ed1b791ebc2592f487892c429602 |
Division of Surgical Oncology, Department of Surgery; Department of Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Koja General Hospital, Jakarta, Indonesia |
Yulian, E.D., Division of Surgical Oncology, Department of Surgery; Siregar, N.C., Department of Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bajuadji, Department of Surgery, Koja General Hospital, Jakarta, Indonesia |
Purpose The efficacy of neoadjuvant chemotherapy for locally advanced breast cancer (LABC) is limited due to drug resistance and cardiotoxic effects. Preclinical studies have shown that statin induces apoptosis and decreases breast cancer cell growth. This study aims to evaluate the role of statin in combination with fluorouracil, adriamycin, and cyclophosphamide (FAC) therapy in LABC patients. Materials and Methods We undertook a randomized, double-blinded, placebo-controlled trial in two centers of Indonesia. Patients were randomly assigned to FAC plus simvastatin (40 mg/day orally) or FAC plus placebo (40 mg/day) for 21 days. The FAC regimen was repeated every 3 weeks. We evaluated the clinical response, pathological response, and toxicities. Results The objective response rate (ORR) for FAC plus simvastatin was 90% (95% confidence interval [CI], 0.99 to 1.67) by per-protocol analysis. No complete responses (CR) were recorded, but there were 48 partial responses. No significant difference was observed between the two groups with the ORR (p=0.103). The pathological CR rate was 6.25% (2 in simvastatin group and 1 in placebo group). Adverse events in both arms were generally mild, mainly consisted of myotoxicity. Human epidermal growth factor receptor 2 (HER2) expression was a factor related to the success of therapeutic response (odds ratio, 4.2; 95% CI, 1.121 to 15.731; p=0.033). Conclusion This study suggests that simvastatin combined with FAC shows improvements in ORR and pathological response in patients with LABC. Although no statistically significant difference was documented, there was a trend for better activity and tolerability. The addition of 40 mg simvastatin may improve the efficacy of FAC in LABC patients with HER2 overexpression. Copyright 2021by theKoreanCancerAssociation |
Breast neoplasms; FAC; Neoadjuvant therapy; Simvastatin |
creatine kinase; cyclophosphamide; doxorubicin; epidermal growth factor receptor 2; fluorouracil; simvastatin; antineoplastic agent; cyclophosphamide; doxorubicin; epidermal growth factor receptor 2; ERBB2 protein, human; fluorouracil; simvastatin; adjuvant therapy; adult; advanced breast cancer; aged; alopecia; anemia; Article; blood toxicity; cancer combination chemotherapy; cancer surgery; clinical outcome; constipation; controlled study; creatine kinase blood level; diarrhea; double blind procedure; drug safety; drug tolerability; fatigue; female; gene overexpression; heart ejection fraction; histopathology; human; hypertransaminasemia; immunohistochemistry; Indonesia; invasive lobular breast carcinoma; leukopenia; lung metastasis; major clinical study; modified radical mastectomy; muc |
Korean Cancer Association |
15982998 |
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33705623 |
Article |
Q1 |
1668 |
1870 |
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161 |
Ramlan A.A., Lestari M.I., Banadji Y., Arif S.K. |
57195941841;57219312983;57225895278;57189846423; |
A national survey of capnography utilization among anaesthesiologists in Indonesia |
2021 |
Trends in Anaesthesia and Critical Care |
40 |
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9 |
13 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109639916&doi=10.1016%2fj.tacc.2021.06.004&partnerID=40&md5=b17959a3c3b317991ee9e2a914ec9547 |
Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National HospitalJakarta, Indonesia; Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Sriwijaya, Palembang, Indonesia; Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Hasanuddin, Makassar, Indonesia; Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia |
Ramlan, A.A., Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National HospitalJakarta, Indonesia, Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia; Lestari, M.I., Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Sriwijaya, Palembang, Indonesia, Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia; Banadji, Y., Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia; Arif, S.K., Department of Anaesthesiology and Intensive Care, Faculty of Medicine Universitas Hasanuddin, Makassar, Indonesia, Indonesian Society of Anaesthesiology and Intensive CareJakarta, Indonesia |
Background: Capnography allows health-care providers to continuously monitor the concentration or partial pressure of carbon dioxide in respiratory gas. The American Society of Anaesthesiologists includes end-tidal carbon dioxide monitoring as mandatory monitoring for patients under sedation and anaesthesia. However, capnography is not widely considered for standard patient monitoring in Indonesia. We aim to investigate the utilization of capnography and reasons for lack of use among anaesthesiologists in Indonesia. Methods: An internet-based questionnaire was distributed to participants of an online anaesthesiology national meeting. Data was collected and managed using REDCap electronic data capture tools hosted at Faculty of Medicine Universitas Indonesia. Results: We received 421 respondents' replies nationwide. Replies from anaesthesiologists (n = 367) was used for data analysis. 55.3% (n = 203) reported the availability of capnography in their hospitals. Approximately 77 (21%) of respondents utilize capnography routinely for intraoperative monitoring, 132 (36%) never use capnography. Only 59 (16%) routinely use capnography for intubation confirmation. The utilization of capnography outside the operating theatre was even lower. As many of 249 (67.9%) never use capnography for monitoring during procedural sedation, while 278 (75.8%) do not utilize capnography during patient transfer. Conclusion: The utilization of capnography for intraoperative monitoring is adopted only by half of anaesthesiologists in Indonesia. Outside the operating theatre capnography use is still limited. Capnography as a standard of care should be implemented in all health care institutions in Indonesia. © 2021 Elsevier Ltd |
Capnography; Intra-operative monitoring; Standard monitoring |
anesthesiologist; Article; capnometry; controlled study; health care quality; health care utilization; human; Indonesia; Internet; intraoperative monitoring; patient safety; patient transport; sedation |
Churchill Livingstone |
22108440 |
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Article |
Q3 |
213 |
18603 |
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162 |
Sylvawani M., Setyohadi B., Purnamasari D., Abdullah M., Kurniawan M.R. |
57225078775;6504721711;36519537700;7103393434;57192808936; |
Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus |
2021 |
Journal of Taibah University Medical Sciences |
16 |
5 |
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719 |
723 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109109686&doi=10.1016%2fj.jtumed.2021.05.007&partnerID=40&md5=4f913f9e9865492b0cdd9860adfea935 |
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sylvawani, M., Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Setyohadi, B., Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Purnamasari, D., Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Abdullah, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kurniawan, M.R., Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia |
Objectives: This study assesses the serum levels of insulin-like growth factor-1 (IGF-1) and sclerostin as markers of decreased bone formation in premenopausal women with type 2 diabetes mellitus. Methods: A cross-sectional study was conducted to measure serum levels of IGF-1 and sclerostin in 40 premenopausal women with and without diabetes mellitus using an enzyme-linked immunosorbent assay. The levels of IGF-1 and sclerostin were compared between the groups using the Mann Whitney test and unpaired t-test, respectively. Results: The median IGF-1 serum levels were 40.60 ng/mL and 42.7 ng/mL in the diabetic and non-diabetic groups, respectively, with no significant difference. The serum levels of sclerostin were significantly higher in the diabetic group than in the non-diabetic group (132.1 pg/mL and 96.0 pg/mL, respectively; p < 0.001). Conclusion: The levels of sclerostin were significantly higher in premenopausal women with diabetes mellitus than in the non-diabetic group. Since sclerostin influences the differentiation and maturation of osteoblasts, serum sclerostin might potentially be useful as a marker of decreased bone formation in premenopausal women with diabetes. © 2021 The Authors |
Diabetes mellitus; IGF-1; Osteoblasts; Premenopause; Sclerostin |
alanine aminotransferase; collagen type 1; creatinine; hemoglobin A1c; insulin; oral antidiabetic agent; sclerostin; somatomedin C; adult; aged; Article; body mass; bone metabolism; cell differentiation; cell maturation; civil servant; comparative study; controlled study; cross-sectional study; diabetic patient; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; housewife; human; major clinical study; non insulin dependent diabetes mellitus; obesity; ossification; osteoblast; premenopause; private sector; protein blood level |
Elsevier B.V. |
16583612 |
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Article |
Q3 |
269 |
15910 |
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