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770 |
Saroyo Y.B., Wibowo N., Irwinda R., Prijanti A.R., Yunihastuti E., Bardosono S., Krisnadi S.R., Permata P.I., Wijaya S., Santawi V.P.A. |
57164888400;15049026900;57190855256;57190863386;57221273925;21933841000;56660648900;57225151181;56685332700;57192917419; |
Oxidative Stress Induced Damage and Early Senescence in Preterm Placenta |
2021 |
Journal of Pregnancy |
2021 |
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9923761 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109338598&doi=10.1155%2f2021%2f9923761&partnerID=40&md5=f6580c90345ba249ad3c787766d49062 |
Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Clinical Nutrition, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Prijanti, A.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Yunihastuti, E., Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Bardosono, S., Department of Clinical Nutrition, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Krisnadi, S.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Indonesia; Permata, P.I., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Wijaya, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Santawi, V.P.A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction. Senescent cells have been demonstrated to release High Mobility Group Box 1 (HMGB1) which induces labor through an inflammatory pathway. This research is aimed at demonstrating whether telomere shortening, proinflammatory HMGB1, and oxidative damage marker 8-OHdG play a role in the placenta of preterm birth in comparison to term birth. Method. A cross-sectional study on 67 full thickness of the placenta obtained from mothers with term and preterm birth. Mothers with clinical signs of infection (fever>38°C, leukocytosis>18000/μL, or abnormal vaginal discharge) and other pregnancy complications were excluded. Real-time polymerase chain reaction was performed to measure T/S ratio and ELISA quantification to measure the amount of HMGB1 and 8-OHdG. Result. A total of 34 placentas from preterm and 33 placentas from term birth were examined. Maternal characteristics were comparable between the two groups. There were no statistical difference of T/S ratio (p=0.181), HMGB1 (p=0.119), and 8-OHdG (p=0.144) between the preterm and term groups. HMGB1 was moderately correlated with 8-OHdG (r=0.314). Telomere T/S ratio of the placenta did not differ between preterm and term labor despite difference in gestational age, suggesting earlier shortening in the preterm group. It is possible that critical telomere length has been achieved in both term and preterm placenta that warrants labor through senescence process. The result of our study also showed that HMGB1 was not correlated to telomere length, due to the fact that HMGB1 is not upregulated until the critical length of telomere for senescence is exhibited. Conclusion. Similar telomere length might be exhibited due to early telomere shortening in preterm birth that mimics the term placenta. The relationship between placental telomere shortening and HMGB1 release remains to be uncovered. Further research is needed to discover the factors leading to early telomere shortening in the placenta of preterm birth. © 2021 Yudianto Budi Saroyo et al. |
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cross-sectional study; female; human; metabolism; newborn; oxidative stress; placenta; pregnancy; prematurity; telomere shortening; Cross-Sectional Studies; Female; Humans; Infant, Newborn; Oxidative Stress; Placenta; Pregnancy; Premature Birth; Telomere Shortening |
Hindawi Limited |
20902727 |
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34258068 |
Article |
Q2 |
828 |
5768 |
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774 |
Atmakusuma T.D., Girson R., Koesnoe S. |
57216961785;14324834100;26028015000; |
Correlations between Iron Load and CD4 in Adult Transfusion-Dependent Beta Thalassemia |
2021 |
Anemia |
2021 |
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5549503 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108909049&doi=10.1155%2f2021%2f5549503&partnerID=40&md5=86934d2b70e3a64770f20d2512ea4dfb |
Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Girson, R., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Koesnoe, S., Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Background. Thalassemia is a hereditary disease, and severe anemia is the main phenotype of major thalassemia. Furthermore, the most important method in the management of this disease is red blood cell transfusion. Regular transfusions administered 1 or 2 times every month improve prognosis and survival. However, there is higher risk of infections and iron overload, especially in transfusion-dependent thalassemia (TDT). Infections are the second leading cause of death in adult TDT, after heart failure. Higher risk of infection is also influenced by multiple blood transfusions which causes alteration in immune response due to alloimmunization, transfusion-related infections, and iron overload. Meanwhile, iron overload in TDT alters both innate and specific immune responses. Furthermore, previous studies have shown the correlation between ferritin with CD4, but this has not been carried out in Indonesia. Therefore, this study aims to determine the correlations between iron overload (serum ferritin and transferrin saturation) and specific immune cells (CD4). Methods. This is a cross-sectional study, and a total number of 64 subjects were examined consecutively. Chest X-ray and blood sera were obtained. The total number of subjects was 64. The seromarkers HBsAg, anti-HCV, and anti-HIV were tested using the ELISA method. Serum ferritin and transferrin saturation was tested using ECLIA, and lymphocyte subsets were analyzed using flowcytometry. Meanwhile, the correlation between variables was determined using Spearman's test. Results. The results showed that 4.9% subjects were HBsAg positive, 10.7% were anti-HCV positive, and none were anti-HIV positive. There were 4 subjects with lung tuberculosis based on the 41 chest X-ray. Meanwhile, there was a weak negative and insignificant correlation between serum ferritin with CD4 (p=0.75; r = -0.04) and a weak positive and insignificant correlation between transferrin saturation with CD4 (p=0.133; r = 0.19). Conclusion. There were no correlations between iron overload (ferritin) and cellular immunity (CD4) in adult transfusion-dependent thalassemia. © 2021 Tubagus Djumhana Atmakusuma et al. |
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C reactive protein; ferritin; hemoglobin; hepatitis B surface antigen; hepatitis C antibody; Human immunodeficiency virus antibody; iron chelating agent; transferrin; tuberculostatic agent; adult; antibiotic therapy; antibody detection; antigen detection; Article; beta thalassemia; blood sampling; blood transfusion; CD4 lymphocyte count; cellular immunity; chronic hepatitis; coinfection; cross-sectional study; disease association; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; facies; female; ferritin blood level; flow cytometry; hemoglobin blood level; hemoglobin E-beta thalassemia; hepatitis B; hepatitis C; human; human cell; Human immunodeficiency virus infection; iron overload; leukocyte count; lung tuberculosis; lymphocyte subpopulation; major clinical study; |
Hindawi Limited |
20901267 |
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Article |
Q2 |
921 |
4948 |
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775 |
Estiasari R., Diwyacitta A., Sidik M., Rida Ariarini N.N., Sitorus F., Marwadhani S.S., Maharani K., Imran D., Arpandy R.A., Pangeran D., Hakim M. |
55240204000;57225009324;56252760000;57225009527;57208331594;57203760168;57189235094;57203976849;49361070700;57203764449;57216861859; |
Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
2021 |
Neurology Research International |
2021 |
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5573839 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108905101&doi=10.1155%2f2021%2f5573839&partnerID=40&md5=7aaf49b7f8adca76fa739b0330ba1aff |
Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Estiasari, R., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Diwyacitta, A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sidik, M., Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Rida Ariarini, N.N., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sitorus, F., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Marwadhani, S.S., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Maharani, K., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Imran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Arpandy, R.A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Pangeran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Hakim, M., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes. Methods. This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography. Results. The MS group had lower BCVA (p=0.001), contrast sensitivity (p<0.001), mean GCIPL thickness (p<0.001), and mean RNFL thickness (p<0.001) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly (p=0.007 and p=0.004, respectively). Disease duration and the number of relapses correlated with delayed P100 latency (r = -0.61, p<0.001 and r = -0.46, p=0.02). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS. Conclusions. The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability. © 2021 Riwanti Estiasari et al. |
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Hindawi Limited |
20901852 |
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Article |
Q3 |
365 |
12980 |
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787 |
Rahman I.A., Rasyid N., Birowo P., Atmoko W. |
57211646827;56245069300;6504153311;57193125664; |
Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis |
2021 |
International Journal of Impotence Research |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107770401&doi=10.1038%2fs41443-021-00419-6&partnerID=40&md5=6fab70d2b92ac45bd379994f51e6be3a |
Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rahman, I.A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Erectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function. © 2021, The Author(s). |
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Springer Nature |
09559930 |
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Article |
Q2 |
508 |
9947 |
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809 |
Prabowo Y., Setiawan I., Kamal A.F., Kodrat E., Labib Zufar M.L. |
56682042400;57223371887;56648996700;57191430080;57223359525; |
Correlation between Prognostic Factors and the Histopathological Response to Neoadjuvant Chemotherapy in Osteosarcoma: A Retrospective Study |
2021 |
International Journal of Surgical Oncology |
2021 |
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8843325 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105720428&doi=10.1155%2f2021%2f8843325&partnerID=40&md5=f2aca94957d4723aa31b40e604603c25 |
Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology Cipto, Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prabowo, Y., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Setiawan, I., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kamal, A.F., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kodrat, E., Department of Anatomical Pathology Cipto, Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Labib Zufar, M.L., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background.Multimodality treatment, incorporating neoadjuvant chemotherapy and adjuvant chemotherapy, is the standard management plan for osteosarcoma that increases the overall survival (OS) rate. However, data regarding prognostic factors affecting the histopathological response following neoadjuvant chemotherapy is limited. Patients and Methods. We retrospectively reviewed patients diagnosed with osteosarcoma in our center between 2008 and 2018. We classified patient characteristics according to gender, age, tumor size, site and stage at diagnosis, site of metastasis, type of surgery, necrosis rate based on the Huvos grading system, and the number of neoadjuvant chemotherapy cycles. We divided response to neoadjuvant chemotherapy into poor responder for patients with Huvos grades 1 and 2 and good responder for patients with Huvos grades 3 and 4. We also documented patients' survival and follow-up information. Results. We reviewed 64 patients within 5-65 years of age, dominated by men (62.5%). The distal femur (53.1%) was the most common site of osteosarcoma. Fifteen (23.4%) patients had a good response while 49 (76.6%) patients were poor responders to neoadjuvant chemotherapy based on the Huvos grading system. Based on multivariate analysis, gender (p = 0.012), age (p = 0.029), symptom duration (p = 0.004), and tumor enlargement after neoadjuvant chemotherapy (p < 0.001) were significantly associated with histopathological response. A scoring system was proposed integrating these significant variables (age > 20 years = 1 point, female gender = 1 point, symptom duration > 12 weeks = 1 point, and increased tumor size after neoadjuvant chemotherapy = 2 points). This scoring system divides patients into two groups with a total score of more than two predicting a poor responder to neoadjuvant chemotherapy. Conclusions. Age, gender, symptoms duration, and tumor size after neoadjuvant chemotherapy are the prognostic features that affect the histopathological response to neoadjuvant chemotherapy in patients with osteosarcoma. © 2021 Yogi Prabowo et al. |
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antineoplastic agent; adjuvant chemotherapy; adolescent; adult; aged; bone tumor; child; female; follow up; human; male; middle aged; mortality; neoadjuvant therapy; osteosarcoma; pathology; preschool child; prognosis; retrospective study; survival analysis; young adult; Adolescent; Adult; Aged; Antineoplastic Agents; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Retrospective Studies; Survival Analysis; Young Adult |
Hindawi Limited |
20901402 |
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33996154 |
Article |
Q3 |
432 |
11391 |
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810 |
Suwantika A.A., Zakiyah N., Abdulah R., Sitohang V., Tandy G., Anartati A., Hidayatullah T., Herliana P., Hadinegoro S.R. |
55757798100;56073623400;9244834900;57201802658;57208105012;35602938500;35117792500;57203394399;57226218772; |
Cost-Effectiveness and Budget Impact Analyses of Pneumococcal Vaccination in Indonesia |
2021 |
Journal of Environmental and Public Health |
2021 |
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7494965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105700019&doi=10.1155%2f2021%2f7494965&partnerID=40&md5=bbd858611fb710b7cc2cabf814a8c66b |
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia; Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
Suwantika, A.A., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Zakiyah, N., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Abdulah, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Sitohang, V., Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Tandy, G., Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Anartati, A., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Hidayatullah, T., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Herliana, P., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Hadinegoro, S.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
As a country with the high number of deaths due to pneumococcal disease, Indonesia has not yet included pneumococcal vaccination into the routine program. This study aimed to analyse the cost-effectiveness and the budget impact of pneumococcal vaccination in Indonesia by developing an age-structured cohort model. In a comparison with no vaccination, the use of two vaccines (PCV10 and PCV13) within two pricing scenarios (UNICEF and government contract price) was taken into account. To estimate the cost-effectiveness value, a 5-year time horizon was applied by extrapolating the outcome of the individual in the modelled cohort until 5 years of age with a 1-month analytical cycle. To estimate the affordability value, a 6-year period (2019-2024) was applied by considering the government's strategic plan on pneumococcal vaccination. In a comparison with no vaccination, the results showed that vaccination would reduce pneumococcal disease by 1,702,548 and 2,268,411 cases when using PCV10 and PCV13, respectively. Vaccination could potentially reduce the highest treatment cost from the payer perspective at $53.6 million and $71.4 million for PCV10 and PCV13, respectively. Applying the UNICEF price, the incremental cost-effectiveness ratio (ICER) from the healthcare perspective would be $218 and $162 per QALY-gained for PCV10 and PCV13, respectively. Applying the government contract price, the ICER would be $987 and $747 per QALY-gained for PCV10 and PCV13, respectively. The result confirmed that PCV13 was more cost-effective than PCV10 with both prices. In particular, introduction cost per child was estimated to be $0.91 and vaccination cost of PCV13 per child (3 doses) was estimated to be $16.61 and $59.54 with UNICEF and government contract prices, respectively. Implementation of nationwide vaccination would require approximately $73.3-$75.0 million (13-14% of routine immunization budget) and $257.4-$263.5 million (45-50% of routine immunization budget) with UNICEF and government contract prices, respectively. Sensitivity analysis showed that vaccine efficacy, mortality rate, and vaccine price were the most influential parameters affecting the ICER. In conclusion, pneumococcal vaccination would be a highly cost-effective intervention to be implemented in Indonesia. Yet, applying PCV13 with UNICEF price would give the best cost-effectiveness and affordability values on the routine immunization budget. © 2021 Auliya A. Suwantika et al. |
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pcv 10; Pneumococcus vaccine; Pneumococcus vaccine; Article; budget; budget impact analysis; case control study; case fatality rate; child; cohort analysis; comparative effectiveness; contract; controlled study; cost effectiveness analysis; drug cost; drug efficacy; economic evaluation; government; health care cost; human; incidence; incremental cost effectiveness ratio; Indonesia; infection prevention; mortality rate; outcome assessment; pneumococcal infection; price; quality adjusted life year; sensitivity analysis; strategic planning; Streptococcus pneumonia; United Nations Children's Fund; vaccination; cost benefit analysis; economics; Budgets; Child; Cost-Benefit Analysis; Humans; Indonesia; Pneumococcal Vaccines; Vaccination |
Hindawi Limited |
16879805 |
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33995536 |
Article |
Q2 |
869 |
5372 |
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820 |
Rini I.S., Gunardi A.J., Yashinta, Kevin J., Marsaulina R.P., Aryandono T., Dachlan I., Dwiprahasto I. |
57189690245;57215216664;57223006688;57223012633;57220026579;23495038400;57210391374;6506398126; |
Quality of Life in Palliative Post-mastectomy Reconstruction: Keystone versus Rotational Flap |
2021 |
Plastic and Reconstructive Surgery - Global Open |
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e3457 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104488039&doi=10.1097%2fGOX.0000000000003457&partnerID=40&md5=4e95d37965469db84b820afb28853499 |
Department of Plastic Surgery, Dharmais Cancer Hospital, Jalan Letjen Jend. S. Parman No. 84-86, West Jakarta, DKI Jakarta, 11420, Indonesia; Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Faculty of Medicine, Universitas Kristen Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Rini, I.S., Department of Plastic Surgery, Dharmais Cancer Hospital, Jalan Letjen Jend. S. Parman No. 84-86, West Jakarta, DKI Jakarta, 11420, Indonesia; Gunardi, A.J., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Yashinta, Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Kevin, J., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Marsaulina, R.P., Faculty of Medicine, Universitas Kristen Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Aryandono, T., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Dachlan, I., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Dwiprahasto, I., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Background: Late stage breast cancer presents with malignant wound causing skin infiltration, pain, bleeding, and malodour, which affect quality of life (QoL). Palliative mastectomy aims to eliminate wound symptoms and requires prolonged wound care to improve QoL. This study aimed to prospectively investigate QoL differences in 2 alternative reconstructive methods: keystone flap and rotational flap. Methods: Twenty-four late stage breast cancer patients with symptoms of cancer wounds were included in this study. They were divided into 2 groups: keystone flap and rotational flap. Each patient's QoL was evaluated using EORTC QLQ-C30 and QLQ-BR23 before and 3 weeks after surgery. Results: Global health post-surgery was significantly improved compared with pre-surgery in all patients (P < 0.001), across both the keystone (P = 0.018) and rotational groups (P = 0.007). Breast symptoms post-surgery were also improved compared with pre-surgery in all patients (P = 0.035). However, when analyzed per group, breast symptoms were only improved significantly in the keystone group (P = 0.013) but not in the rotational group (P = 0.575). When compared between 2 groups, future perspective post-surgery in the keystone group [100 (0-100)] was better than the rotational group [66.7 (0-100)], (P = 0.020). Conclusions: Reconstructive surgery after mastectomy improves QoL in late stage breast cancer patients. The keystone flap is superior to the rotational flap in improving global health and breast symptoms. © 2021 Georg Thieme Verlag. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
759 |
6437 |
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842 |
Rahyussalim A.J., Marsetio A.F., Kamal A.F., Supriadi S., Setyadi I., Pribadi P.M., Mubarok W., Kurniawati T. |
55212166100;57192180884;56648996700;16040272500;57216397660;57194227346;57208440063;55213290600; |
Synthesis, Structural Characterization, Degradation Rate, and Biocompatibility of Magnesium-Carbonate Apatite (Mg-Co3Ap) Composite and Its Potential as Biodegradable Orthopaedic Implant Base Material |
2021 |
Journal of Nanomaterials |
2021 |
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6615614 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103563575&doi=10.1155%2f2021%2f6615614&partnerID=40&md5=071473665891e53e20135fe57fd742de |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan; Stem Cells and Tissues Engineering Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, 10340, Indonesia |
Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Marsetio, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Kamal, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Setyadi, I., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Pribadi, P.M., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Mubarok, W., Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan; Kurniawati, T., Stem Cells and Tissues Engineering Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, 10340, Indonesia |
Suitable biomechanical properties with a degradation rate parallel to normal bone healing time are vital characteristics for biodegradable implant material in orthopaedics. Magnesium (Mg) is a natural micronutrient as well as biodegradable metal with biomechanical characteristics close to that of the human bone, while carbonate apatite (CO3Ap) is a biological apatite with good osteoconductivity which allows bone healing without forming fibrotic tissue. We fabricated a Mg-CO3Ap composite with various content ratios by powder metallurgy, various milling times (3, 5, and 7 hours) at 200 RPM, warm compaction at 300°C and pressure of 265 MPa, sintering at 550°C, holding time of 1 hour, heating rate of 5°C/minutes, and room atmosphere cooling. Specimens were successfully created and had a density comparable to that of the human bone (1.95-2.13 g/cm3). Good biocompatibility was found on Mg-10% CO3Ap composite (66.67% of viable cells). Nevertheless, its biomechanical properties and corrosion resistance were inferior to the human bone. Additionally, the materials of the composites make the surrounding environment alkaline. Interparticle consolidation and grain size were dissatisfactory due to microstructural pores presumably formed by the Mg(OH)2 layer and oxidation process during sintering. However, alkaline condition caused by the material corrosion by-product might be beneficial for bone healing and wound healing process. Modifications on fabrication parameters are needed to improve interparticle consolidation, refine grain size, improve biomechanical strength, reduce corrosion products, and improve the degradation rate. © 2021 Ahmad Jabir Rahyussalim et al. |
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Apatite; Biocompatibility; Biomechanics; Composite structures; Corrosion resistance; Degradation; Grain size and shape; Orthopedics; Powder metallurgy; Sintering; Tissue regeneration; Biodegradable implants; Biomechanical characteristics; Biomechanical properties; Fabrication parameters; Magnesium carbonate apatites; Structural characterization; Surrounding environment; Wound healing process; Magnesium metallurgy |
Hindawi Limited |
16874110 |
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463 |
10759 |
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848 |
Gunardi E.R., Susilo S.A. |
57192910998;57191052854; |
Menstrual Pattern and Characteristics of One-Rod and Two-Rod Levonorgestrel Implant Users |
2021 |
Obstetrics and Gynecology International |
2021 |
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2904542 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103051337&doi=10.1155%2f2021%2f2904542&partnerID=40&md5=9c88e8c5346ee41a0b8def57849e05c1 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia; Susilo, S.A., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia |
Introduction. The maternal mortality ratio (MMR) in Indonesia reaches 359 per 100,000 live births. The long-acting reversible contraceptive (LARC) method is an effective contraceptive choice for reducing MMR. The contraceptive implant is one of the LARCs that has low usage due to lack of education about the side effects. This study aims to compare the menstrual pattern and characteristics between one-rod and two-rod levonorgestrel implant users. Methods. A prospective cohort study was performed in patients at Cipto Mangunkusumo Hospital (RSCM) from March 2016 to May 2018. Subject recruitment was done by consecutive sampling. This study was conducted from March 2016 until May 2019. Statistical analysis was performed on the data using the chi-square test to determine the relationship between menstrual pattern and characteristics, and the use of one-rod or two-rod levonorgestrel implants. Results. A total of 140 subjects participated in the study, comprising 70 (50%) one-rod users and 70 (50%) two-rod users. In the first month, 32.9% one-rod users experienced amenorrhea, 22.9% experienced shortened menstrual period, 30% experienced normal menstrual period, and 14,2 % experienced lengthened menstrual period. In comparison, in the first month, 41.4% two-rod users experienced amenorrhea, 15.7% experienced shortened menstrual period, 32.9% experienced normal menstrual period, and 10% experienced lengthened menstrual period. There was no significant difference in menstrual patterns and characteristics between one-rod and two-rod levonorgestrel implant users. Conclusion. There was no significant difference in menstrual patterns and characteristics between one-rod and two-rod levonorgestrel implant users. Implications. Menstrual patterns and characteristics from levonorgestrel implants user can help clinicians to reduce discontinuation rate from the acceptors. Further research should be conducted to know other side effects aside from menstrual bleeding patterns. © 2021 Eka Rusdianto Gunardi and Sulaeman Andrianto Susilo. |
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injectable contraceptive agent; levonorgestrel; oral contraceptive agent; adult; amenorrhea; Article; body mass; breast feeding; cohort analysis; comparative study; controlled study; data analysis software; female; human; long-acting reversible contraception; major clinical study; menstrual cycle; menstruation; obesity; prospective study; underweight |
Hindawi Limited |
16879589 |
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648 |
7760 |
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857 |
Sahar N., Muharam R., Pradhita A.D., Thuffi R., Zulhulaifah W.O., Birowo P. |
57212464367;57191492732;57212471291;57212475033;57222324817;6504153311; |
Expression of E-Cadherin in Pig-Tailed Monkey (Macaca nemestrina) Endometrium after Controlled Ovarian Hyperstimulation |
2021 |
BioMed Research International |
2021 |
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8824614 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102282318&doi=10.1155%2f2021%2f8824614&partnerID=40&md5=174042679bf5a7630610257f7a24b9a7 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Pradhita, A.D., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thuffi, R., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zulhulaifah, W.O., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
An increase of steroid hormones in controlled ovarian hyperstimulation (COH) procedures is reducing the success rate in assisted reproductive technology (ART), and this includes the pregnancy rate and/or implantation rate. Research has found that the decrease in the success rate occurred due to the decreased expression of the protein that is needed to prepare the endometrium so that the embryo could attach. The aim of the study was to analyse the changes in E-chaderin expression due to COH and its relations with increased level of steroid hormones as one of the proteins in the endometrium. There were 13 samples of stored biological tissue from Macaca nemestrina endometrial tissue; came from one group of natural cycles as the control group (n=4) and three groups of stimulated cycles. The first stimulated cycle group was injected by a 30 IU dose of rFSH (n=2). The second stimulated cycle group was injected by a 50 IU dose of rFSH (n=4). The third stimulated cycle group was injected by a 70 IU dose of rFSH (n=3). The expression of E-cadherin was measured by the immunohistochemistry (IHC) technique. Estradiol (E2) and progesterone (P4) levels were assessed using ELISA and have already been done. The IHC staining expression of E-cadherin was found in the cytoplasm of glandular epithelium. Immunostaining measurement used the H_SCORE. We found that the expression of E-cadherin within the group was not significantly different (p value: 0.178). Similarly, both the correlation between the estradiol level with E-cadherin and the correlation between the progesterone level with E-cadherin were not significantly different (p value: 0.872 and p value: 0.836). The conclusion is that the level of E-Cadherin expression in the endometrium that were taken in themiddle secretion phase not affected by the dose regimen that given. In addition, the level of expression is not influenced by the increase of serum E2 and P4 levels. © 2021 Nurhuda Sahar et al. |
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buserelin; chorionic gonadotropin; estradiol; progesterone; recombinant follitropin; uvomorulin; cadherin; animal experiment; animal tissue; Article; comparative study; controlled study; cytoplasm; endometrium; enzyme linked immunosorbent assay; estradiol blood level; female; follicular phase; immunohistochemistry; Macaca nemestrina; mitosis; nonhuman; ovary hyperstimulation; progesterone blood level; protein expression; retrospective study; animal; biosynthesis; endometrium; metabolism; ovulation induction; Animals; Cadherins; Endometrium; Female; Macaca nemestrina; Ovulation Induction |
Hindawi Limited |
23146133 |
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33708995 |
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772 |
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