No records
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87 |
Miranda E., Bramono K., Rizky L.A., Hayun |
57208259598;9843236700;57193502812;37053937800; |
Preparation and stability evaluation of ll-37 cream |
2021 |
International Journal of Applied Pharmaceutics |
13 |
6 |
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139 |
143 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121048883&doi=10.22159%2fIJAP.2021V13I6.39639&partnerID=40&md5=1b6a1a02cc0417196461dd2568afa7d5 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rizky, L.A., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hayun, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Objective: The present study aimed to prepare LL-37 in a cream formulation (O/W emulsion) and evaluate its stability by determining the physical changes in the cream and concentration of LL-37 using validated high-performance liquid chromatography. Methods: The method was conducted at room temperature using a C18 column (5 µm × 250 mm × 4.6 mm) as a stationary phase, a mixture of 0.1% trifluoroacetic acid (TFA)/water (A) and 0.1% TFA/acetonitrile (B) (85:15) as the mobile phase, a flow rate of 1.0mL/min, an d photodiode array set at 228 nm as the detector. The method was validated in compliance with the Association of Official Analytical Chemists and International Conference on Harmonization guidelines. It demonstrated excellent linearity, accuracy, precision, specificity, the limit of detection, and limit of quantitation. Results: The chromatographic analysis indicated minimal degradation of LL-37 during the 12-week, with a predicted expiry time of 99 and 75 mo stored at 4 °C and 28 °C, respectively. Conclusion: LL-37 cream establishes good physical characteristics and stabilizes the active ingredient, especially at 4 °C and 28 °C storage. Therefore, the emulsion delivery system of LL-37 cream is harmless and stable as a novel alternative vehicle of LL-37. © 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd. |
Cream; High-performance liquid chromatography; LL-37; Stability |
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Innovare Academics Sciences Pvt. Ltd |
09757058 |
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Article |
Q3 |
238 |
17272 |
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95 |
Laksmita Y.A., Sidik M., Siregar N.C., Nusanti S. |
57209279067;57257519600;6508087790;57189727162; |
Neuroprotective Effects of Citicoline on Methanol-Intoxicated Retina Model in Rats |
2021 |
Journal of Ocular Pharmacology and Therapeutics |
37 |
9 |
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534 |
541 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120545903&doi=10.1089%2fjop.2021.0018&partnerID=40&md5=cfe07289839f2866220d3438db7fac57 |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Laksmita, Y.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Sidik, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nusanti, S., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia |
Purpose: This study aims to evaluate the effect of citicoline administration in suppressing retinal damage due to methanol intoxication. This study hypothesizes that citicoline will minimize the loss of retinal ganglion cells (RGCs), minimize disruption of photoreceptors, suppress ganglion layer edema, increase expression of bcl-2 as the antiapoptotic protein, and decrease expression of caspase-3 as the proapoptotic protein. Methods: Fifteen Sprague-Dawley rats were divided into 5 groups, including the control group (A); methanol groups, observed on day 3 (B1) and day 7 (B2); and methanol+citicoline groups, observed on day 3 (C1) and day 7 (C2). Rats in groups B and C were placed in an inhalation chamber filled with N2O:O2 during the experiment, then methanol was administered orally. Citicoline, 1 g/kg every 24 h, was orally administered for group C. Enucleation was performed and retinas of rats were prepared for histology and immunohistochemistry examination to evaluate photoreceptor morphology and RGC density, as well as bcl-2 and caspase-3 expression. Results: RGC density of citicoline-treated intoxicated rats was higher than no-citicoline methanol-intoxicated rats on both day 3 (P < 0.001) and day 7 (P < 0.001). The ganglion layer thickness of citicoline-treated intoxicated rats was thinner than no-citicoline intoxicated rats, which means citicoline-treated rats had milder ganglion layer edema. Citicoline-treated rats showed higher bcl-2 and lower caspase-3 expression than no-citicoline rats. No differences were found in photoreceptor findings among groups. Conclusions: This study demonstrated citicoline's potential benefits for management of ocular methanol intoxication. However, more preclinical and clinical trials are needed to obtain a preferred dosage and timing of citicoline administration. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
citicoline; methanol intoxication; methanol optic neuropathy; neuroprotector; retina; toxic optic neuropathy |
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Mary Ann Liebert Inc. |
10807683 |
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34495749 |
Article |
Q2 |
727 |
6812 |
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98 |
Yusharyahya S.N., Bramono K., Indriatmi W., Prasetyo M., Ascobat P., Hestiantoro A., Wiraguna A.A.G.P. |
57211780941;9843236700;57189888041;57192905252;55795863600;8743255100;20437026700; |
Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
11 |
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95 |
103 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119480025&doi=10.7324%2fJAPS.2021.1101113&partnerID=40&md5=020217cd5f217dbc98ba3162ac9d99f1 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ascobat, P., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiraguna, A.A.G.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Postmenopausal hypoestrogenism is associated with skin aging, for which phytoestrogen derived from the seeds of Trigonella foenum graecum (fenugreek) is expected to be an alternative solution to reduce wrinkles and increase the thickness of postmenopausal women’s skin. This study was a randomized, double-blind, controlled 12-weeks trial conducted at a general hospital in Jakarta, Indonesia, from January to November 2019. Subjects were 50 postmenopausal women divided into two groups: the intervention group was given 5% fenugreek cream and base cream was given to the placebo group. The results of the independent t-test showed that both groups were able to achieve statistically significant improvement in wrinkle scores on the forehead, crow’s feet, and nasolabial folds which was assessed by photography scoring based on Bazin’s skin aging atlas for Asian skin volume 2 but there was no significant disparity between both groups at all time points. Dermal thickness was assessed by high-resolution ultrasound GE LOGIQ E9 (18 MHz), which showed similar results for both groups with significant improvements in the 8th week compared to baseline and a significant decrease by the 12th week. No significant differences were observed in the skin wrinkle score and skin thickness after the application of fenugreek cream compared to placebo.We suspect that a concentration of 5% was not adequate for the expected antiskin aging effects. Further studies are necessary to determine a more appropriate fenugreek concentration to permit clinical use as an antiskin aging therapy in postmenopausal women. © 2021 Shannaz Nadia Yusharyahya et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License |
Dermal thickness; fenugreek; postmenopausal skin; skin wrinkle |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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128 |
Fadrian F., Chen K., Kumalawati J., Rumende C.M., Shatri H., Nelwan E.J. |
57268114000;57428620500;6504406695;14325966300;28767986500;14527452900; |
The Validation of Drug Resistance in Pneumonia (DRIP) Score in Predicting Infections due to Drug-Resistant Pathogens in Community-acquired Pneumonia at Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
2021 |
Acta medica Indonesiana |
53 |
4 |
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416 |
422 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123567110&partnerID=40&md5=9488cfa84614808f64df6510f7925f6d |
1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Division of Tropical Medicine and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, alas University - M. Djamil Hospital, Padang, Jakarta, Indonesia |
Fadrian, F., 1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Division of Tropical Medicine and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, alas University - M. Djamil Hospital, Padang, Jakarta, Indonesia; Chen, K.; Kumalawati, J.; Rumende, C.M.; Shatri, H.; Nelwan, E.J. |
BACKGROUND: The emergence of drug-resistant pathogens (DRP) in recent years possibly contributes to the common problems associated with community-acquired pneumonia. However, to predict the risk of the ailment, the DRIP score is mainly applied, although no validation study has been reported in Indonesia. Therefore, the score prediction accuracy in the population, patient characteristics and germ patterns appears indefinite, particularly for Cipto Mangunkusumo Hospital, Jakarta. The purpose of this study is to determine the DRIP performance as an instrument in predicting infections due to drug-resistant pathogens (DRP) in community-acquired pneumonia at Cipto Mangunkusumo Hospital. METHODS: This research employed a cross-sectional design, where the subjects were community-acquired pneumonia patients treated between January 2019 and June 2020. In addition, adequate medical records of the participants were obtained. The condition is defined as DRP when the sputum culture results show resistance to non-pseudomonal β-lactam antibiotics, macrolides, and respiratory fluoroquinolones. Furthermore, the score performance was analyzed by determining the calibration and discrimination values, using the Hosmer-Lemeshow test and AUROC, respectively. RESULTS: A total of 254 subjects were known to have satisfied the selection criteria. These participants were categorized into DRP and non-DRP groups, with 103 (40.6%) and 151 (59.4%) patients, correspondingly. The DRIP calibration analysis using the Hosmer-Lemeshow test obtained p-value = 0.001 (p <0.05), while an AUC value of 0.759 (CI 95%, 0.702-0.810) was derived from the ROC curve. However, at a score of ≥ 4, the DRIP showed sensitivity, specificity, positive and negative predictive values of 70.9, 92.7, 86.9, and 82.3%, respectively. CONCLUSION: The DRIP score demonstrated a significant performance in predicting infections due to DRP in community-acquired pneumonia. |
community-acquired pneumonia; DRIP score; resistant pathogens |
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NLM (Medline) |
01259326 |
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35027488 |
Article |
Q3 |
321 |
14162 |
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129 |
Nelwan E.J., Guterres H., Pasaribu A.I., Shakinah S., Limato R., Widodo D. |
14527452900;57223285438;57428543800;57428569400;57196224631;8231822900; |
The Comparison of Point Prevalence Survey (PPS) and Gyssens Flowchart Approach on Antimicrobial Use Surveillance in Indonesian National Referral Hospital |
2021 |
Acta medica Indonesiana |
53 |
4 |
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505 |
511 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123566730&partnerID=40&md5=0eb0821dbbca8a19666af97b0fdd062d |
1. Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia 2. Infection and Immunology Research Cluster, Indonesian Medical Research Institute Faculty of Medicine Universitas Indonesia, Indonesia 3. Member of Antimicrobial Resistance Control Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nelwan, E.J., 1. Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia 2. Infection and Immunology Research Cluster, Indonesian Medical Research Institute Faculty of Medicine Universitas Indonesia, Indonesia 3. Member of Antimicrobial Resistance Control Cipto Mangunkusumo HospitalJakarta, Indonesia; Guterres, H.; Pasaribu, A.I.; Shakinah, S.; Limato, R.; Widodo, D. |
The antimicrobial resistance (AMR) rate in Indonesia is steadily rising, despite the existing national action plan in 2014. In line with the Global Action Plan on AMR, proper surveillance on antimicrobial usage and resistance are needed. At present, antimicrobial surveillance (AMS) data in Indonesia is heterogeneous, fragmented, and localized. The common method of antimicrobial surveillance (AMS) in referral hospitals is by implementing Gyssens flowchart during Antimicrobial Resistance Control Program Committee clinical rounds. However, the recent method of AMS with Point Prevalence Survey (PPS) offers many advantages include its concise and simple protocol, large data collection, shorter required time, comprehensive data outcomes, real-time data, and standardized parameters. In low-middle income countries such as Indonesia with its restricted resources in AMS, PPS is superior compared to the 'traditional' hospital clinical round in generating representative and homogenous outcomes that can be compared to data from other centers worldwide. |
antimicrobial; Gyssens Flowchart; Indonesia; Point Prevalence Survey |
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NLM (Medline) |
01259326 |
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35027501 |
Article |
Q3 |
321 |
14162 |
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131 |
Maulahela H., Fauzi A. |
57189612709;36518523000; |
Peripancreatic Tuberculosis Lymphadenopathy: The Role of Endoscopic Ultrasound for Diagnosis |
2021 |
Acta medica Indonesiana |
53 |
4 |
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457 |
459 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123566183&partnerID=40&md5=db2cd4e2d6a90740d0bc3e39263c3c1d |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Fauzi, A. |
Pancreatic and peripancreatic tuberculosis is a rare abdominal tuberculosis. Diagnosis for pancreatic tuberculosis can be challenging. Conventional imaging tools may show mass or malignancy in the pancreas. Endoscopic ultrasound (EUS) is an excellent tools for evaluating pancreas and peri pancreas region. It also allows us to obtain tissue sample for cytology and histopathology. Here we present a case of peripancreatic tuberculosis lymphadenopathy that mimic pancreatic mass. His symptoms were also nonspecific (weight loss, epigastric pain, and irregular fever). From EUS evaluation we found that there was no mass but multiple lymphadenopathy around the pancreas and then performed FNA. The result of the cytology was granuloma inflammation and caseous necrosis which is compatible with tuberculosis infection. From this case illustration we conclude that EUS is an important diagnostic tool for pancreatic lesion to avoid unnecessary surgery. |
endoscopic ultrasound; lymphadenopathy; Pancreas; tuberculosis |
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NLM (Medline) |
01259326 |
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35027493 |
Article |
Q3 |
321 |
14162 |
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133 |
Shatri H., Prasetyaningtyas A., Putranto R., Rinaldi I. |
28767986500;57426347900;56074051000;23475122400; |
Palliative Prognostic Index Validation in Hospitalized Advanced Cancer Patients in Indonesia Tertiary Hospitals |
2021 |
Acta medica Indonesiana |
53 |
4 |
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442 |
449 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123460876&partnerID=40&md5=6a2a641fbdfa3aa8f7eb17fb4fc4458e |
1. Division of Psychosomatic and Pallliative, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo HospitalJakarta, Indonesia |
Shatri, H., 1. Division of Psychosomatic and Pallliative, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo HospitalJakarta, Indonesia; Prasetyaningtyas, A.; Putranto, R.; Rinaldi, I. |
BACKGROUND: Accurate prediction of survival is important for advanced cancer patients to determine medical interventions plan the patient's lives and prepare for their death. The palliative prognostic index (PPI) is most popular scores used worldwide to predict life expectancy in advanced cancer palliative patients. The purpose of this study was to test validity and the performance of PPI in Cipto Mangunkusumo Hospital as a Tertiary Referral Nasional Hospital. METHODS: This retrospective cohort study, uses total subject during study with consecutive sampling. Palliative prognostic index was assessed by a palliative care team (PCT). Demographic data were summarized as n (%) and Chi square for categorical variables and median or mean for continuous variables. Overall survival was calculated using the Kaplan-Meier method with hazard ratios. The performance of PPI analyzed using SPSS version 20.0, includes for Receiving Operator Characteristics (ROC) and Hosmer-Lemeshow calibration test. RESULTS: 160 patients were included in the PPI study. The subjects have an average age of 50.08 years and are mostly women 68.10%. 28 (17.50%) had symptoms of dyspnoea, 22 (14.60%) pneumonia, and 19 (11.90%) had pain. The number of patients who died during hospitalisation was 83 (51.90%). PPI sum score >6 109 (68,10%). Calibration performance PPI score reached x2 = 8.915 (p = 0.259), and showed correlation r 0.799 (p 0.000). The accuracy of PPI scores in predicting survival in advanced cancer patients in studies for survival <3 weeks 81%, with a sensitivity of 85%, specificity 70%, PPV 86%, and NPV 67%. Predictive accuracy of survival within 3-6 weeks had 76%, sensitivity 66%, specificity 88%, PPV 85% and NPV 70%. PPI score discrimination performance is had a AUC value of 0.822 (95% CI 0.749-0.895). CONCLUSION: Palliative Prognostic Index (PPI ) is valid and has good performance in predicting the survival of advanced cancer patients and may be used to help clinicians in palliative care consultation. |
Cancer; palliative prognostic index (PPI); tertiary hospital; validation |
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NLM (Medline) |
01259326 |
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35027491 |
Article |
Q3 |
321 |
14162 |
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134 |
Gamalliel N., Sutanto R.L., Wardhani A.N.H. |
57222183873;57222060277;57409481900; |
To involve or not to involve: youth participation in Indonesia's pandemic campaign |
2021 |
The Lancet Regional Health - Western Pacific |
15 |
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100290 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122707972&doi=10.1016%2fj.lanwpc.2021.100290&partnerID=40&md5=fd7cc1adaa04029c8ef04d93e3a955e5 |
National COVID-19 Volunteer, Indonesian Medical Students’ Executive Boards Association, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Gamalliel, N., National COVID-19 Volunteer, Indonesian Medical Students’ Executive Boards Association, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sutanto, R.L., National COVID-19 Volunteer, Indonesian Medical Students’ Executive Boards Association, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wardhani, A.N.H., National COVID-19 Volunteer, Indonesian Medical Students’ Executive Boards Association, Jakarta, Indonesia, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
[No abstract available] |
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Elsevier Ltd |
26666065 |
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Note |
#N/A |
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138 |
Gunardi T.H., Susantono D.P., Victor A.A., Sitompul R. |
57195939686;57353411000;57191055282;8312163900; |
Atopobiosis and dysbiosis in ocular diseases: Is fecal microbiota transplant and probiotics a promising solution? |
2021 |
Journal of Ophthalmic and Vision Research |
16 |
4 |
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631 |
643 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119915775&doi=10.18502%2fJOVR.V16I4.9754&partnerID=40&md5=8d0e2b295a398c85ff1c28564276103b |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Gunardi, T.H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Susantono, D.P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Victor, A.A., Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sitompul, R., Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: To highlight the role of atopobiosis and dysbiosis in the pathomechanism of autoimmune uveitis, therefore supporting fecal microbiota transplant (FMT) and probiotics as potential targeted-treatment for uveitis. Methods: This review synthesized literatures upon the relation between gut microbiota, autoimmune uveitis, FMT, and probiotics, published from January 2001 to March 2021 and indexed in PubMed, Google Scholar, CrossRef. Results: The basis of the gut-eye axis revolves around occurrences of molecular mimicry, increase in pro-inflammatory cytokines, gut epithelial barrier disruption, and translocation of microbes to distant sites. In patients with autoimmune uveitis, an increase of gut Fusobacterium and Enterobacterium were found. With current knowledge of aforementioned mechanisms, studies modifying the gut microbiome and restoring the physiologic gut barrier has been the main focus for pathomechanism-based therapy. In mice models, FMT and probiotics targeting repopulation of gut microbiota has shown significant improvement in clinical manifestations of uveitis. Consequently, a better understanding in the homeostasis of gut microbiome along with their role in the gut-eye axis is needed to develop practical targeted treatment. Conclusion: Current preliminary studies are promising in establishing a causative gut-eye axis relationship and the possibility of conducting FMT and probiotics as targeted treatment to mitigate autoimmune uveitis, to shorten disease duration, and to prevent further complications. © 2021 GUNARDI ET AL. THIS IS AN OPEN ACCESS ARTICLE DISTRIBUTED UNDER THE CREATIVE COMMONS ATTRIBUTION LICENSE | PUBLISHED BY KNOWLEDGE E |
Atopobiosis; Autoimmune; Dysbiosis; Gut-Eye Axis; Uveitis |
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Knowledge E |
20082010 |
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Review |
Q3 |
557 |
9058 |
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141 |
Findyartini A., Raharjanti N.W., Greviana N., Prajogi G.B., Setyorini D. |
56543777300;57226872499;57197709749;57221911632;57218906783; |
Development of an app-based e-portfolio in postgraduate medical education using entrustable professional activities (Epa) framework: Challenges in a resource-limited setting |
2021 |
Asia Pacific Scholar |
6 |
4 |
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92 |
106 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119047428&doi=10.29060%2fTAPS.2021-6-4%2fOA2459&partnerID=40&md5=6cdd410ca553690d4851ccd981856007 |
Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Oncology Radiation, Faculty of Medicine, Universitas Indonesia, Indonesia |
Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Raharjanti, N.W., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Greviana, N., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Prajogi, G.B., Department of Oncology Radiation, Faculty of Medicine, Universitas Indonesia, Indonesia; Setyorini, D., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction: E-portfolio may facilitate the entrustment process from supervisors to residents in postgraduate medical education. The present study was aimed at identifying necessary features of an e-portfolio application and to conduct pilot study in a teaching hospital. Methods: Six programs participated. Eight interviews with education directors and six focus group discussions with residents and supervisors were completed for the needs analysis stage. The application was developed based on the thematic analysis of the needs analysis stage. The mobile-app e-portfolio pilot was conducted for four weeks and a modified version of the System Usability Scale (SUS) was distributed to participants following the pilot program. Results: Key features of the e-portfolio were identified. A total of 45 supervisors and 66 residents participated in the pilot study. The residents utilised the application according to the clinical activities and supervision level, and the information was fed to the supervisors as per the application design. Challenges during the pilot study in terms of feedback provision and residents’ workload which influence the e-portfolio use for entrustment decisions are discussed. Conclusion: Current e-portfolio features were created for supervision and are potential to facilitate the entrustment process in Entrustable Professional Activities (EPA) implementation. The pilot study highlighted challenges of the implementation which should be considered for future improvement. © 2021 TAPS. All rights reserved. |
E-Portfolio; Entrustable Professional Activities; Needs Analysis; Pilot Study; Postgraduate Medical Education; Supervision |
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National University of Singapore, Faculty of Law |
24249335 |
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#N/A |
#N/A |
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