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11 |
Tenda E.D., Asaf M.M., Pradipta A., Kumaheri M.A., Susanto A.P. |
57189692101;57216406843;57216644806;56460248100;57221504275; |
The COVID-19 surge in Indonesia: what we learned and what to expect |
2021 |
Breathe |
17 |
4 |
210146 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125813131&doi=10.1183%2f20734735.0146-2021&partnerID=40&md5=e838dc0478f791b7743b4f42a51b2464 |
Division of Respirology and Critical Illness, Dept of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Genomik Solidaritas Indonesia (GSI) Lab, Jakarta, Indonesia |
Tenda, E.D., Division of Respirology and Critical Illness, Dept of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Asaf, M.M., Division of Respirology and Critical Illness, Dept of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pradipta, A., Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Genomik Solidaritas Indonesia (GSI) Lab, Jakarta, Indonesia; Kumaheri, M.A., Genomik Solidaritas Indonesia (GSI) Lab, Jakarta, Indonesia; Susanto, A.P., Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Genomik Solidaritas Indonesia (GSI) Lab, Jakarta, Indonesia |
[No abstract available] |
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European Respiratory Society |
18106838 |
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Editorial |
Q2 |
677 |
7384 |
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12 |
Ramlan A.A.W., Mahri I., Firdaus R., Sugiarto A. |
57195941841;57459772200;57188923555;57189612291; |
Comparison of Efficacy of Premedication between Dexmedetomidine and Midazolam Intranasal for the Prevention of Emergence Delirium in Children Undergoing Ophthalmic Surgery |
2021 |
Turkish Journal of Anaesthesiology and Reanimation |
49 |
6 |
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439 |
444 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124935387&doi=10.5152%2fTJAR.2021.1305&partnerID=40&md5=bd1c40a8ff29473a6db3aa32aacb92ad |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mahri, I., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Firdaus, R., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Emergence delirium (ED) is a condition that can occur when a child recovers from anaesthesia uncomfortably. ED can potentially injure children and indirectly discomforts parents. Various interventions were carried out to reduce ED, but there is no specific standard that has been established to prevent ED. Dexmedetomidine and midazolam are said to be effective in reducing ED. This study aims to determine the effectiveness of intranasal dexmedetomidine premedication compared to intranasal midazolam to prevent ED in children undergoing eye surgery. Methods: This study was a double-blinded randomised clinical trial. Paediatric patients aged 1-12 years with physical status ASA 1 and 2 who underwent eye surgery under general anaesthesia using sevoflurane inhalation were included in the study. There were 64 children obtained by consecutive sampling who underwent eye surgery in our institution between February and May 2019. The subjects were then randomised into the dexmedetomidine group and the midazolam group. Effectiveness was assessed from ED events, recovery time and post-premedication desaturation events. Data analysis was performed using Chi-square test and Mann–Whitney test. Results: ED incidence in the dexmedetomidine group was 11.18% compared to 28.12% in the midazolam group (P = .109). The recovery time was found to be at a median of 6 minutes for both groups, and no desaturation was found in either group. Conclusion: There is statistically no significant difference between the effectiveness of intranasal dexmedetomidine and midazolam premedication 30 minutes before induction to prevent ED occurrence in children undergoing eye surgery. © 2021 by Turkish Society of Anaesthesiology and Reanimation. |
Delirium; Dexmedetomidine; Emergence; Eye surgery; Midazolam |
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AVES |
2667677X |
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Article |
Q3 |
322 |
14155 |
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13 |
Sumapraja K., Hestiantoro A., Liem I.K., Boediono A., Jacoeb T.Z. |
55819683500;8743255100;55802927800;9040094200;57192887569; |
Effect of conditioned medium of umbilical cord-derived mesenchymal stem cells as a culture medium for human granulosa cells: An experimental study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
12 |
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1037 |
1044 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124898321&doi=10.18502%2fijrm.v19i12.10054&partnerID=40&md5=aa14230b44e7cc7c0f12adca3c46c2b5 |
Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Sumapraja, K., Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hestiantoro, A., Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Boediono, A., Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jacoeb, T.Z., Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Background: The umbilical cord-derived mesenchymal stem cells conditioned medium (UC-MSCs-CM) produces secretomes with anti-apoptotic properties, and has the potential to prevent apoptosis of granulosa cells (GC) during controlled ovarian hyperstimulation. Objective: To observe the effect of UC-MSCs-CM on the interaction between pro-and anti-apoptotic proteins and the influence of growth differentiation factor 9 (GDF9) production in GC. Materials and Methods: UC-MSCs-CM was collected from umbilical cord stem cell culture on passage 4. GC from 23 women who underwent in vitro fertilization were cultured and exposed to UC-MSCs-CM for 24 hr. Then RNA of the GC was extracted and the mRNA expression of BCL-2 associated X (BAX), survivin and GDF9 were analysed using quantitative real-time PCR. The spent culture media of the GC were collected for measurement of insulin growth factor 1 using ELISA. Results: The expression of BAX was significantly different after UC-MSCs-CM exposure (4.09E-7 vs. 3.74E-7, p = 0.02). No significant changes occurred in survivin, BAX/survivin ratio, and GDF9 expression after UC-MSCs-CM exposure (p > 0.05). The IGF-1 level of the CM was significantly higher after the CM was used as a culture medium for GC (2.28 vs. 3.07 ± 1.72, p ≤ 0.001). A significant positive correlation was found between survivin and GDF9 (r = 0.966, p ≤ 0.001). Conclusion: IGF-1 produced by UC-MSCs-CM can work in paracrine fashion through the IGF receptor, which can inhibit BAX and maintain GDF9 production. Moreover, under the influence of UC-MSCs-CM, GC are also capable of producing IGF-1, which can impact GC through autocrine processes. © Sumapraja et al. |
BAX; Conditioned medium; GDF9; IGF-1; Survivin |
anti apoptotic protein; baculoviral IAP repeat containing protein 5; complementary DNA; growth differentiation factor 9; Muellerian inhibiting factor; pro apoptotic protein; protein; protein Bax; protein bcl 2; recombinant follitropin; somatomedin; unclassified drug; adult; anesthesia; antiapoptotic activity; antral follicle count; Article; autocrine signaling; cell culture; clinical article; DNA synthesis; enzyme linked immunosorbent assay; female; granulosa cell; human; human cell; in vitro fertilization; information processing; mRNA expression level; oocyte; ovary follicle fluid; real time polymerase chain reaction; RNA extraction; umbilical cord mesenchymal stem cell |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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14 |
Kalaij A.G.I., Dirjayanto V.J., Yusuf S.M., Nelwan E.J. |
57223906853;57404619000;57359274400;14527452900; |
Immunogenicity and safety of adenovirus-based vector vaccines for COVID-19: a systematic review and meta-analysis |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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264 |
278 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123701532&doi=10.13181%2fmji.oa.215559&partnerID=40&md5=480b6760fb0761aee17ad344ee18a3ce |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Infectious Disease and Immunology Research Center, Indonesia Medical and Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kalaij, A.G.I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dirjayanto, V.J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yusuf, S.M., Infectious Disease and Immunology Research Center, Indonesia Medical and Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND Despite various research on vaccine development, severe acute respiratory syndrome coronavirus 2 infection continues to spread. Thus, developing a more effective vaccine for production and clinical efficacy is still in high demand. This review aimed to assess the immunogenicity and safety of adenovirus-based vector vaccines (Ad-vaccines) including Ad5-vectored, ChAdOx1 nCoV-19, rAd26-S or rAd5-S, and Ad26.COV2.S as the promising solutions for COVID-19. METHODS We conducted a systematic review and meta-analysis of clinical trials based on the preferred reporting items for systematic reviews and meta-analyses guidelines through PubMed, Scopus, Cochrane, and EBSCOhost until August 17, 2021. We implemented inclusion and exclusion criteria and assessed the studies using the US National Toxicology Program’s Office of Health Assessment and Translation risk of bias rating tool for human and animal studies. Pooled estimates of odds ratio (OR) were analyzed using fixed-effect model. RESULTS This systematic review yielded 12 clinical studies with a total of 75,105 subjects. Although the studies were heterogeneous, this meta-analysis showed that Ad-vaccine significantly increased protection and immune response against COVID-19 with a pooled efficacy of 84.68% compared to placebo (p<0.00001). Forest plot also indicated that Ad-vaccine conferred protection against moderate to severe COVID-19 with a pooled OR of 0.26 (p<0.00001). Ad-vaccine had also shown a good safety profile with local site pain and fever as the most common side effects. CONCLUSIONS Ad-vaccine had shown a good immunogenicity for COVID-19 with a good pooled efficacy and was proven safe for COVID-19 patients. © 2021 Authors. |
Adenovirus vaccine; COVID-19; Immunogenicity; Safety; SARS-CoV-2 |
adenovirus vaccine; vector vaccine; Article; comparative effectiveness; coronavirus disease 2019; drug delivery system; drug efficacy; drug safety; genetic reassortment; human; immune response; immunogenicity; meta analysis; outcome assessment; practice guideline; risk assessment; sensitivity analysis; seroconversion; systematic review; vaccination |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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15 |
Lukman P.R., Saputra A., Elvira S.D., Heriani, Almasyhur A.F., Putri L.A., Alfonso C.A., Noviasari R.R. |
55981460300;57431501600;57192888533;57431901600;57203618023;57432304200;7004331573;57431697600; |
Efficacy of video-based psychotherapy in reducing psychological distress COVID-19 patients treated in isolation ward |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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250 |
255 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123688789&doi=10.13181%2fmji.oa.215473&partnerID=40&md5=05a78950b452a144715a92b0e790ed60 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry, Columbia University Irving Medical Center, New York, United States; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lukman, P.R., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Saputra, A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Elvira, S.D., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heriani, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Almasyhur, A.F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, L.A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alfonso, C.A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Psychiatry, Columbia University Irving Medical Center, New York, United States; Noviasari, R.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND Hospitalized patients with COVID-19 experience isolation during treatment, which may cause psychological distress. Thus, alternative ways to deliver psychological support are needed when face-to-face therapy is not possible. This study aimed to investigate the efficacy of video-based psychotherapy in reducing distress in COVID-19 patients treated in an isolation ward. METHODS This quasi-experimental trial without a control group included 42 COVID-19 patients aged 20–59 years. Participants were recruited conveniently in the COVID-19 isolation ward in Cipto Mangunkusumo Hospital, Jakarta, Indonesia. They watched three brief psychotherapy videos including relaxation, managing thoughts and emotions, and mindfulness for approximately 30 min. The videos were created by the Department of Psychiatry, Faculty of Medicine, Universitas Indonesia. Subjective units of distress scale (SUDS) was measured before and after watching all videos. Data were analyzed using the Wilcoxon-signed rank test. RESULTS All 42 subjects finished watching the videos. 31 subjects experienced a significant median decrease in SUDS score after the intervention. The effect size of the psychotherapy videos for the SUDS score was 0.485 (95% CI 0.302 to 0.634). CONCLUSIONS Watching psychotherapy videos is effective in reducing the SUDS score for COVID-19 patients in an isolation ward. Our brief video-based psychotherapy intervention has reduced psychological distress in hospitalized COVID-19 patients with limited access to face-to-face consultations due to the risk of disease transmission. © 2021 Authors. |
COVID-19; Instructional film and audio; Patient isolation; Psychological distress; Psychotherapy |
adult; Article; clinical article; coronavirus disease 2019; distress syndrome; emotion; female; human; length of stay; male; middle aged; mindfulness; psychotherapy; quasi experimental study; questionnaire; relaxation sensation; subjective unit of distress scale; video based psychotherapy |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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16 |
Hidayati E.R.N., Suharti A., Suratinoyo A.T., Zahra S.R., Nusdwinuringtyas N. |
57192909138;57430912200;57430912300;57431910100;56608215500; |
Feasibility of the modified 30-second sit-to-stand test in an isolation ward omoderate COVID-19 |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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306 |
310 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123687687&doi=10.13181%2fmji.bc.215477&partnerID=40&md5=46eb378aa55f3d5a5501b012c001442f |
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Hidayati, E.R.N., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Suharti, A., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Suratinoyo, A.T., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Zahra, S.R., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Nusdwinuringtyas, N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND The recovery after prolonged immobilization during hospitalization because of COVID-19 is the primary goal of moderate to severe COVID-19 rehabilitation. Lower extremity muscle function assessment after immobilization is needed before starting mobilization. Hence, this study aimed to evaluate the feasibility of the modified 30-second sit-to-stand test (m30STS) as one of the prospective tools of functional capacity assessment in moderate COVID-19. METHODS This cross-sectional study recruited the subjects consecutively. All eligible subjects with oxygen saturation (SaO2 ) ≥95% with or without oxygen supplementation performed the m30STS following the Bohannon’s guidelines. The score of m30STS was calculated based on the number of stands completed within 30 sec. A higher score of the m30STS indicated better lower extremity function. RESULTS Mean score of m30STS was 13.3. No subjects had oxygen desaturation or increased heart rate, and no fall incidents occurred. CONCLUSIONS The m30STS is feasible and safe to evaluate lower extremity for moderate COVID-19 patients with SaO2 >95%. The absence of oxygen desaturation and increase in heart rate showed no increased oxygen consumption during the test. © 2021 Authors. |
COVID-19; Functional capacity; Modified 30-second sit-to-stand tes |
adult; Article; coronavirus disease 2019; cross-sectional study; female; functional status; heart rate; hospital department; human; isolation; length of stay; major clinical study; male; middle aged; mobilization; muscle strength; oxygen desaturation; oxygen saturation; prospective study; sit-to-stand test |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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17 |
Hidayat R., Asmaniar F., Priambodo A., Mesiano T., Kurniawan M., Rasyid A., Har S. |
57225289998;57219959732;57431511100;57204830976;57432111000;56703146700;57431910000; |
Endovascular treatment of an unruptured ophthalmic artery aneurysm with a flow diverter: A case report |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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297 |
300 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123683324&doi=10.13181%2fmji.cr.204899&partnerID=40&md5=25be03988554b8a69e078a04d109a317 |
Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Hidayat, R., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Asmaniar, F., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priambodo, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mesiano, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kurniawan, M., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Har, S., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
An unruptured aneurysm is often asymptomatic or present without neurological deficits, causing severe morbidity. However, the potential of this defect to rupture requires proper management. Herein, we report a case of an unruptured saccular aneurysm of the ophthalmic artery with initial clinical seizures. The patient was treated by flow diversion which redirects the blood flow that normally leads to the protrusion of the aneurysm back to the main vessel. Flow diversion is chosen because it is less risky and has a faster recovery time than other treatment options, but it is more expensive than others. Although this technology is not new, there is no report on its implementation in Indonesia. The patient was prescribed antiplatelet treatment for at least 6 months post-treatment, then she showed no sign of seizure or new focal neurological deficits 4 months post-treatment. The patients were expected to undergo digital subtraction angiography evaluation 6 months after flow diversion treatment, but it has not been performed due to the coronavirus disease 2019 pandemic. © 2021 Authors. |
Aneurysm; Computed tomography angiography; Digital subtractangiography; Endovascular; Ophthalmic artery; Seizures |
acetylsalicylic acid; candesartan; clopidogrel; phenytoin; adult; aneurysm; Article; blindness; blood flow; case report; clinical article; coil embolization; computed tomographic angiography; computer assisted tomography; coronavirus disease 2019; digital subtraction angiography; electroencephalography; endovascular surgery; epilepsy; female; follow up; human; hypertension; internal carotid artery; middle aged; neurologic disease; nuclear magnetic resonance imaging; ophthalmic artery; pandemic; saccular aneurysm; seizure; stenosis; thorax radiography; thrombocyte; vertebral artery |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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18 |
Firdaus R., Theresia S., Austin R., Tiara R. |
57423039300;57222095380;57422434500;57422587800; |
Propofol effects in rodent models of traumatic brain injury: A systematic review |
2021 |
Asian Biomedicine |
15 |
6 |
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253 |
265 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123275403&doi=10.2478%2fabm-2021-0032&partnerID=40&md5=fdc2eb2da5eaacf73d60546fd4a9fc72 |
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Firdaus, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Theresia, S., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Austin, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Tiara, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Background: Traumatic brain injury (TBI) causes high mortality and disability worldwide. Animal models have been developed to explore the complex processes in TBI. Propofol is used to manage head injuries during surgical intervention and mechanical ventilation in patients with TBI. Many studies have investigated the neuroprotective effect of propofol on TBI. However, other studies have shown neurotoxic effects. Objectives: To review systematically the literature regarding the neuroprotective and neurotoxic effects of propofol in rodent models of TBI. Methods: Data from rodents as models of TBI with propofol as one of the intervention agents, and/or comparing the neuroprotective effects of propofol with the other substances in rodent models of TBI, were obtained from PubMed, EBSCO Host, and ProQuest databases. The PRISMA 2020 statement recommendations were followed and research questions were developed based on PICOS guidelines. Data was extracted from the literature using a standardized Cochrane method. Results: We analyzed data from 12 articles on physiological changes of experimental animals before and after trauma, the effects of propofol administration, and the observed neurotoxic effects. The effects of propofol administration were observed in terms of changes in traumatic lesion volume, the release of antioxidants and inflammatory factors, and the neurological function of rodent models of TBI. Conclusion: Propofol has neuroprotective and neurotoxic effects via several mechanisms, and various doses have been used in research to determine its effects. The timing of administration, the dose administered, and the duration of administration contribute to determine the effect of propofol in rodent models of TBI. However, the doses that produce neuroprotective and neurotoxic effects are not yet clear and further research is needed to determine them. © 2021 Riyadh Firdaus et al., published by Sciendo. |
anesthetics; brain injuries, traumatic; neuroprotection; propofol; Rodentia |
calpain; carbon dioxide; catalase; citicoline; diazepam; erythropoietin; fentanyl; glucose; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; isoflurane; ketamine; malonaldehyde; mitogen activated protein kinase p38; morphine; nitric oxide; oxygen; pentobarbital; propofol; semaphorin; superoxide dismutase; tumor necrosis factor; xanthine oxidase; adult; antiinflammatory activity; antioxidant activity; arterial carbon dioxide tension; arterial oxygen tension; blood pH; brain edema; brain injury; Cochrane Library; combination drug therapy; controlled study; core temperature; diffuse brain injury; dose response; drug megadose; female; glucose blood level; head injury; heart rate; hematocrit; lesion volume; lipid peroxidation; low drug dose; male; mean arterial pressur |
Sciendo |
19057415 |
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Review |
Q4 |
178 |
20816 |
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19 |
Tantri A.R., Sukmono R.B., Atmadja L.S. |
57188933853;57204643526;57422197300; |
Comparison of recovery time with target controlled infusion of propofol with sevoflurane anesthesia using bispectral index monitoring in vitrectomy surgery |
2021 |
Anaesthesia, Pain and Intensive Care |
25 |
6 |
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707 |
712 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123272271&doi=10.35975%2fapic.v25i6.1689&partnerID=40&md5=a8e07d9abeb4fd0d01a1bb03c52954f1 |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia |
Tantri, A.R., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia; Sukmono, R.B., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia; Atmadja, L.S., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia |
Background: Rapid recovery after anesthesia is critical and is associated with the anesthetic agents used. The bispectral index (BIS) monitoring to guide anesthetic agents' doses may play a significant role in the recovery time. This study compared recovery time after Target Controlled Infusion (TCI) of propofol with sevoflurane anesthesia by using BIS monitoring during vitrectomy surgery. Methodology: This was a prospective observational, randomized study on 40 patients aged 18-65 y, physical status ASA I-II, body mass index (BMI) 18-30 kg/m2, who underwent vitrectomy surgery. Subjects were randomly assigned into two groups, Group P - the TCI propofol group, and Group S - the sevoflurane group. Subjects in the Group P received TCI propofol (Schnider), and subjects in the Group S received sevoflurane for anesthesia maintenance, with a targeted BIS score of 40-60. Inj. fentanyl 1 μg/kg was administered if there was an increase in blood pressure, heart rate and/or BIS that could not be overcome by increasing the dose of TCI propofol or sevoflurane. Recovery time was calculated from when the maintenance regimen was stopped until the patient was able to obey simple commands. Recovery time, fentanyl consumption, postoperative agitation, nausea and vomiting incidence were noted and analyzed with SPSS v21.0 for Windows. T-Test or Mann-Whitney U test was performed to analyze the data. Result: Recovery time in the Group P [11.5 (5-25) min)] was not significantly different from the Group S [9 (4-18) min, p = 0.139]. Total fentanyl consumption was higher in the Group P than in the Group S (1.765 vs. 1.428 μg/kg). The frequency of agitation during recovery was higher in the Group S than in the Group P (30% vs. 20%) Conclusion: There was no significant difference in recovery time between TCI propofol and sevoflurane anesthesia using BIS monitoring in vitrectomy. Total fentanyl consumption was higher in the propofol group than in the sevoflurane group. The impact of these anesthetic regimens on postoperative agitation needs further investigation. © 2021 Faculty of Anaesthesia, Pain and Intensive Care, AFMS. All rights reserved. |
BIS; Bispectral index monitoring; Intravenous anesthesia; Propofol; Sevoflurane; Target Controlled Infusion; TCI; Vitrectomy |
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Faculty of Anaesthesia, Pain and Intensive Care, AFMS |
16078322 |
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Article |
Q3 |
170 |
21404 |
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20 |
Kartika R.W., Alwi I., Yunir E., Waspadji S., Bardosono S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Suyatna F.D., Reksodiputro M.H. |
57223447932;15055173800;36520254800;8678136400;21933841000;57272979000;56275255400;57016857300;6507225348;56039633100;35090488800; |
A new innovation in topical diabetic foot ulcer; hyaluronic acid platelet-rich fibrin (HAPRF) gel - a study in inflammation and angiogenesis |
2021 |
Bali Medical Journal |
10 |
3 |
|
901 |
908 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123104761&doi=10.15562%2fbmj.v10i3.2317&partnerID=40&md5=60a98c7a6392eaa4cf35d6bc5c895812 |
Medical Science Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Departement Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kartika, R.W., Medical Science Faculty of Medicine, Universitas Indonesia, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, M.H., Departement Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Indonesia ranks 6th out of ten countries with the highest number of diabetes patients. An increase followed this condition in the prevalence of diabetic foot ulcers by around 15%. This study demonstrated the ability of combination of Platelet Rich Fibrin (PRF) and Hyaluronic Acid (HA) to reduce inflammation in diabetic foot ulcer (DFU) healing. Methods: In the baseline, all patients received the same treatment including wound debridement. There were 20 subjects divided into two groups; HAPRF and PRF. A part of sample was processed into lysate and stored in -80oC. The rest is applied as a topical therapy in DFU base on intervention. We analyzed the inflammation using two methods; swab in DFU and fibrin gel of HAPRF or PRF and ELISA on day-3 and day-7. We also measure the granulation index by digital photograph and analyze use ImageJ at the same time. Result: There were 20 diabetic patients with DFUs, performed analysis of IL-6 lysate gel HAPRF decrease significantly compare with PRF on day 3 (p= 0.038) and day-7 (p = 0.034). Granulation index evaluation, in HAPRF increase on day-3 (p = 0.043), day-7 (p = 0.049), and day-14 (p = 0.041). Conclusion: A-PRF +HA administration leads to reduce IL-6 levels, and accelerated wound healing of DFUs patients. HAPRF directly aids epithelialization and granulation index. © 2021, Sanglah General Hospital. All rights reserved. |
Diabetic foot ulcer; Fibrin; Granulation index; Hyaluronic acid; Inflammation; Platelet |
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Sanglah General Hospital |
20891180 |
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Article |
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