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Viswanathan S., Hiew F.L., Siritho S., Apiwattanakul M., Tan K., Quek A.M.L., Estiasari R., Remli R., Bhaskar S., Islam B.M., Aye S.M.M., Ohnmar O., Umapathi T., Keosodsay S.S., Hoang N.T.T., Yeo T., Pasco P.M. |
56372225400;56520422700;15519966800;57195288799;37032197900;13605538000;55240204000;6504090091;57226417398;57194464797;55644071900;57201460031;6602092493;57201460833;57310352700;57310352800;6506559205; |
Impact of Covid-19 on the therapeutic plasma exchange service within the South East Asian region: Consensus recommendations and global perspectives |
2021 |
Journal of Clinical Apheresis |
36 |
6 |
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849 |
863 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117763064&doi=10.1002%2fjca.21937&partnerID=40&md5=3fb4e2326e829716a437226b18f33390 |
Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Department of Neurology, Bumrungrad International Hospital and Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Neurology, Neurological Institute of Thailand, Bangkok, Thailand; Department of Neurology, National Neuroscience Institute, Singapore; Division of Neurology, Department of Medicine, National University Health System, Singapore; Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Neurology, National University of Malaysia, Kuala Lumpur, Malaysia; Department of Medicine, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia; Department of Laboratory Sciences and Services Division, The International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh; Department of Neurology, Aryu International Hospital, Yangon, Myanmar; Department of Neurology, Yangon General Hospital, Yangon, Myanmar; Department of Neurology, Laos General Hospital, Vientiane, Laos; Department of Neurology, Military Hospital 175, Ho Chi Minh City, Viet Nam; Department of Neurosciences, Philippine General Hospital, Manila, Philippines |
Viswanathan, S., Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Hiew, F.L., Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Siritho, S., Department of Neurology, Bumrungrad International Hospital and Siriraj Hospital, Mahidol University, Bangkok, Thailand; Apiwattanakul, M., Department of Neurology, Neurological Institute of Thailand, Bangkok, Thailand; Tan, K., Department of Neurology, National Neuroscience Institute, Singapore; Quek, A.M.L., Division of Neurology, Department of Medicine, National University Health System, Singapore; Estiasari, R., Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Remli, R., Department of Neurology, National University of Malaysia, Kuala Lumpur, Malaysia; Bhaskar, S., Department of Medicine, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia; Islam, B.M., Department of Laboratory Sciences and Services Division, The International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh; Aye, S.M.M., Department of Neurology, Aryu International Hospital, Yangon, Myanmar; Ohnmar, O., Department of Neurology, Yangon General Hospital, Yangon, Myanmar; Umapathi, T., Department of Neurology, National Neuroscience Institute, Singapore; Keosodsay, S.S., Department of Neurology, Laos General Hospital, Vientiane, Laos; Hoang, N.T.T., Department of Neurology, Military Hospital 175, Ho Chi Minh City, Viet Nam; Yeo, T., Department of Neurology, National Neuroscience Institute, Singapore; Pasco, P.M., Department of Neurosciences, Philippine General Hospital, Manila, Philippines |
Introduction: Therapeutic plasma exchange (TPE) for neuroimmunological disorders has played an increasingly important role within the Southeast Asian (SEA) region. The South East Asian Therapeutic Plasma exchange Consortium (SEATPEC) was formed in 2018 to promote education and research on TPE within the region. The advent of the Covid-19 pandemic has produced challenges for the development and expansion of this service. Methodology: A qualitative and semi-quantitative questionnaire-based survey was conducted by SEATPEC member countries from January to June 2020 (Phase 1) and then from July 2020 to January 2021 in (Phase 2) to assess the impact of Covid-19 on regional TPE. Objectives: The study's main objectives were to explore the challenges experienced and adaptations/adjustments taken by SEATPEC countries in order to continue safe and efficient TPE during the Covid-19 pandemic. Results: The pandemic was found to disrupt the delivery of TPE services in all SEATPEC countries. Contributing factors were multifactorial due to overstretched medical services, staff shortages, quarantines and redeployments, fear of acquiring Covid-19, movement restriction orders, and patient's psychological fear of attending hospitals/testing for Covid-19. All SEATPEC countries practiced careful stratification of cases for TPE (electives vs emergencies, Covid-19 vs non-Covid-19 cases). SEATPEC countries had to modify TPE treatment protocols to include careful preprocedure screening of patient's for Covid-19, use of personal protective equipment (PPE) and post-TPE sanitization of machines and TPE suites. Conclusion: Based on the responses of the survey, SEATPEC countries produced a consensus statement with five recommendations for safe and effective TPE within the region. © 2021 Wiley Periodicals LLC. |
Covid-19; impact; South East Asia; therapeutic plasma exchange |
complication; consensus; epidemiology; human; neurologic disease; neurologist; pandemic; plasma exchange; procedures; questionnaire; Southeast Asia; Asia, Southeastern; Consensus; COVID-19; Humans; Nervous System Diseases; Neurologists; Pandemics; Plasma Exchange; SARS-CoV-2; Surveys and Questionnaires |
John Wiley and Sons Inc |
07332459 |
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34694652 |
Article |
Q2 |
697 |
7146 |
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52 |
Nababan S.H.H., Mansjoer A., Fauzi A., Gani R.A. |
57205443199;24335647800;36518523000;23495930300; |
Predictive scoring systems for in-hospital mortality due to acutely decompensated liver cirrhosis in Indonesia |
2021 |
BMC Gastroenterology |
21 |
1 |
392 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117564939&doi=10.1186%2fs12876-021-01972-6&partnerID=40&md5=8028251c29a052e830e58ba7b4786ff1 |
Hepatobiliary Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Clinical Epidemiology Unit, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia; Gastroenterology Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia |
Nababan, S.H.H., Hepatobiliary Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Mansjoer, A., Clinical Epidemiology Unit, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia; Fauzi, A., Gastroenterology Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia; Gani, R.A., Hepatobiliary Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia |
Background: Acutely decompensated liver cirrhosis is associated with high medical costs and negatively affects productivity and quality of life. Data on factors associated with in-hospital mortality due to acutely decompensated liver cirrhosis in Indonesia are scarce. This study aims to identify predictors of in-hospital mortality and develop predictive scoring systems for clinical application in acutely decompensated liver cirrhosis patients. Methods: This was a retrospective cohort study using a hospital database of acutely decompensated liver cirrhosis data at Cipto Mangunkusumo National General Hospital, Jakarta (2016–2019). Bivariate and multivariate logistic regression analyses were performed to identify the predictors of in-hospital mortality. Two scoring systems were developed based on the identified predictors. Results: A total of 241 patients were analysed; patients were predominantly male (74.3%), had hepatitis B (38.6%), and had Child–Pugh class B or C cirrhosis (40% and 38%, respectively). Gastrointestinal bleeding was observed in 171 patients (70.9%), and 29 patients (12.03%) died during hospitalization. The independent predictors of in-hospital mortality were age (adjusted OR: 1.09 [1.03–1.14]; p = 0.001), bacterial infection (adjusted OR: 6.25 [2.31–16.92]; p < 0.001), total bilirubin level (adjusted OR: 3.01 [1.85–4.89]; p < 0.001) and creatinine level (adjusted OR: 2.70 [1.20–6.05]; p = 0.016). The logistic and additive scoring systems, which were developed based on the identified predictors, had AUROC values of 0.899 and 0.868, respectively. Conclusion: The in-hospital mortality rate of acutely decompensated liver cirrhosis in Indonesia is high. We have developed two predictive scoring systems for in-hospital mortality in acutely decompensated liver cirrhosis patients. © 2021, The Author(s). |
Acute decompensation; In-hospital mortality; Liver cirrhosis; Prognosis; Scoring system |
epidemiology; hospital mortality; human; Indonesia; liver cirrhosis; male; prognosis; quality of life; retrospective study; Hospital Mortality; Humans; Indonesia; Liver Cirrhosis; Male; Prognosis; Quality of Life; Retrospective Studies |
BioMed Central Ltd |
1471230X |
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34670501 |
Article |
Q2 |
935 |
4832 |
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53 |
Goenarjo R., Dupuy O., Fraser S., Berryman N., Perrochon A., Bosquet L. |
57192916469;55250097700;56214500000;35602918000;55628941600;6602849323; |
Cardiorespiratory fitness and prefrontal cortex oxygenation during Stroop task in older males |
2021 |
Physiology and Behavior |
242 |
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113621 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117564635&doi=10.1016%2fj.physbeh.2021.113621&partnerID=40&md5=ac7c0401817c51ece69279b94bfe1755 |
Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France; Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa (Ontario), Canada; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; Laboratoire HAVAE (EA 6310), Université de Limoges, Limoges, France; Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada; Département des Sciences de l'activité physique, Université du Québec à Montréal (UQAM), Montréal, Canada |
Goenarjo, R., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Dupuy, O., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada; Fraser, S., Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa (Ontario), Canada; Berryman, N., Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada, Département des Sciences de l'activité physique, Université du Québec à Montréal (UQAM), Montréal, Canada; Perrochon, A., Laboratoire HAVAE (EA 6310), Université de Limoges, Limoges, France; Bosquet, L., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada, Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada |
Aim: The aim of the current study was to assess whether executive function and prefrontal oxygenation are dependent on fitness level and age in older adults. Methods: Twenty-four healthy males aged between 55 and 69 years old were recruited for this study. They were stratified by age, leading to the creation of two groups: 55–60 years old and 61–69 years old. A median split based on CRF created higher- and lower-fit categories of participants. Cerebral oxygenation was assessed using functional near-infrared spectroscopy (fNIRS) during a computerized Stroop task. Accuracy (% of correct responses) and reaction times (ms) were used as behavioural indicators of cognitive performances. Changes in oxygenated (∆[HbO2]) and deoxygenated (∆[HHb]) hemoglobin were measured to capture neural changes. Repeated measures ANOVAs (CRF × Age × Stroop conditions) were performed to test the null hypothesis of an absence of interaction between CRF, Age and executive performance. Results: We also found an interaction between CRF and age on reaction times (p = .001), in which higher fitness levels were related to faster reaction times in the 61–69 year olds but not in the 55–60 year olds. Regarding ΔHHb, the ANOVA revealed a main effect of CRF in the right PFC (p = .04), in which higher-fit participants had a greater Δ[HHb] than the lower-fit (d = 1.5). We also found fitness by age interaction for Δ[HHb] in the right PFC (p = .04). Conclusion: Our results support the positive association of CRF on cerebral oxygenation and Stroop performance in healthy older males. They indicated that high-fit individuals performed better in the 61–69 year olds group, but not in the 55–60 years old group. We also observed a greater PFC oxygenation change (as measured by Δ[HHb]) in the high-fit individuals. © 2021 |
Cardiorespiratory fitness; Cerebral oxygenation; Older adults; Prefrontal cortex; Stroop |
hemoglobin; oxyhemoglobin; adult; age; aged; Article; blood oxygenation; brain oxygen consumption; brain radiography; cardiorespiratory fitness; controlled study; deoxygenation; executive function; functional near-infrared spectroscopy; hemoglobin blood level; human; human experiment; male; measurement accuracy; normal human; peak oxygen uptake; prefrontal cortex; reaction time; Stroop test; executive function; metabolism; middle aged; prefrontal cortex; Stroop test; Aged; Cardiorespiratory Fitness; Executive Function; Humans; Male; Middle Aged; Oxyhemoglobins; Prefrontal Cortex; Stroop Test |
Elsevier Inc. |
00319384 |
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34648819 |
Article |
Q1 |
960 |
4644 |
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54 |
Harefa, Wijaya I.P., Muhadi, Rumende C.M., Nasution S.A., Koesnoe S., Marbun M.B., Shatri H. |
57298868100;57193731572;57189615533;14325966300;57189373134;26028015000;57195201827;28767986500; |
The association between 24-h blood pressure variability and major adverse cardiac events (MACE) in hospitalized patients with acute myocardial infarction: a retrospective cohort study |
2021 |
Egyptian Heart Journal |
73 |
1 |
88 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117340121&doi=10.1186%2fs43044-021-00213-1&partnerID=40&md5=c9f1acb17b55e567ab93cb770f13356a |
Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia |
Harefa, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Muhadi, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Rumende, C.M., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Nasution, S.A., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Koesnoe, S., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Marbun, M.B., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Shatri, H., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia |
Background: Acute myocardial infarction (AMI) is major cardiovascular disease that causes high morbidity and mortality. In AMI, ischemia and necrosis affected some cardiomyocytes leading to a decrease in myocardial contractility which is followed by an acute proinflammation reaction and increased sympathetic tone. Meanwhile, high blood pressure variability (BPV) causing an increased left ventricular workload, heart rate, myocardial oxygen demand and induces proinflamations and endothelial dysfunction. Therefore a high BPV and its associated pathological effects are likely to aggravate the physiological function of the heart and affect the emergence of acute cardiac complications in AMI patients. This study aims to investigate the association’s between short-term BPV and major adverse cardiac events (MACE) in AMI patients. This retrospective cohort study used simple random sampling to identify AMI patients who were hospitalized at Cipto Mangunkusumo National Hospital between January 2018 and December 2019. Mann Withney was performed to investigate the association between BPV and MACE. Results: The average systolic BPV value which was calculated as standard deviation (SD) and average real variability (ARV) was higher in the MACE group than in the non-MACE group. Systolic SD and systolic ARV in the MACE group were 13.28 ± 5.41 mmHg and 9.88 ± 3.81 mmHg respectively. In the non-MACE group, systolic SD and systolic ARV were 10.76 (4.59–26.17) mmHg and 8.65 (3.22–19.35) mmHg respectively. There was no significant association between BPV and MACE. However, there were significant differences between systolic SD and systolic ARV in patients with hypertension who experienced MACE and patients without hypertension who experienced MACE. Conclusions: The BPV of AMI patients who experience MACE was higher than that of non-MACE AMI patients. There was no significant association between BPV ​​and MACE during the acute phase of AMI. © 2021, The Author(s). |
Acute myocardial infarction; Average real variability; Blood pressure variability; Major adverse cardiac events |
acute heart infarction; adult; aged; Article; blood pressure monitoring; blood pressure variability; cohort analysis; controlled study; diastolic blood pressure; female; heart function; hospital patient; human; hypertension; major adverse cardiac event; major clinical study; male; retrospective study; systolic blood pressure |
Springer Science and Business Media Deutschland GmbH |
11102608 |
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Article |
Q3 |
212 |
18617 |
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55 |
Mansyur M., Sagitasari R., Wangge G., Sulistomo A.B., Kekalih A. |
37085506800;57290722900;36497482500;57024018500;55633562200; |
Long working hours, poor sleep quality, and work-family conflict: determinant factors of fatigue among Indonesian tugboat crewmembers |
2021 |
BMC Public Health |
21 |
1 |
1832 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116761265&doi=10.1186%2fs12889-021-11883-6&partnerID=40&md5=4563534bbfe5b850aae54955a11550c5 |
Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Occupational Medicine Post Graduate Study Program, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Mansyur, M., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Sagitasari, R., Occupational Medicine Post Graduate Study Program, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wangge, G., South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Sulistomo, A.B., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kekalih, A., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Tugboat crewmembers are susceptible to fatigue during their 24-h work shifts, despite the availability of rest time. The fatigue experienced by seafarers contributes to marine accidents and metabolic and cardiovascular diseases, which have long-term effects. This study aimed to analyse the association between working hours and fatigue and other possibly related factors in tugboat crewmembers. Method: This comparative cross-sectional study included 127 tugboat crew members from 15 randomly chosen tugboats in Samarinda Harbor, Indonesia. Their fatigue levels while at work were measured using a reaction timer and standardised questionnaire. Personal and occupational data of crewmembers, including age, marital status, rating (job ranking), duration on board, length of seafaring experience, watch system, smoking status, coffee and alcohol consumption, and working hours, were collected. Moreover, sleep quality and stress levels related to work-family conflict were measured and analysed using the Pittsburgh Sleep Quality Index (PSQI) and Work-Family Conflict Scale (WCFS), respectively. Results: The study found that 40.2% of the subjects were classified as having fatigue. The determinant factors were long working hours (> 72 h/week), poor sleep quality, and work-family conflict [adj. OR = 13.32; 95%-CI (4.78–31.23)] and p < 0.001, [adj. OR = 4.49 (1.39–14.52)] and p = 0.012, [adj. OR = 2.87 (1.12–7.33)] and p = 0.028, respectively. However, personal and occupational factors, including age, marital status, duration on board, length of seafaring experience, smoking status, and coffee and alcohol consumption, were not significantly associated with crewmember fatigue. Conclusion: The incidence of fatigue among Indonesian tugboat crewmembers operating on the Mahakam River was considerably high. Working hours, sleep quality, and work-family conflict were strongly associated with fatigue in tugboat crewmembers; therefore, the working hours of tugboat crewmembers need to be improved. Crewmember lifestyle variables need to be studied further. © 2021, The Author(s). |
Fatigue; Seafarer; Sleep quality; Tugboat crewmembers; Work-family conflict; Working hours |
cross-sectional study; family conflict; fatigue; human; Indonesia; sleep; work schedule; Cross-Sectional Studies; Family Conflict; Fatigue; Humans; Indonesia; Sleep; Work Schedule Tolerance |
BioMed Central Ltd |
14712458 |
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34627227 |
Article |
Q1 |
1230 |
3166 |
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56 |
Gunardi E.R., Surya R., Syafitri I., Pasidri Y. |
57192910998;56986345100;57195381844;57226151144; |
Impact of one-rod levonorgestrel implant on the blood chemistry profile |
2021 |
Scientific Reports |
11 |
1 |
20141 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116742568&doi=10.1038%2fs41598-021-99801-z&partnerID=40&md5=604f40cda19708636ac9b97fd82f17a7 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syafitri, I., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The aim of this study was to investigate the effect of a one-rod levonorgestrel implant on the blood chemistry profile, including random blood glucose (RBG), haemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and the lipid profile, including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta, from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated every 6 month up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. p < 0.05 was considered a significant value. The Hb, RBG, AST, and lipid profile levels were significantly different before and 6 months after one-rod implant insertion (p < 0.05). However, for 24 months, all of the parameters were still within normal limits and did not differ clinically. One-rod levonorgestrel implant insertion has a minimal effect on all blood chemistry profiles. © 2021, The Author(s). |
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cholesterol; contraceptive agent; high density lipoprotein cholesterol; levonorgestrel; lipid; low density lipoprotein cholesterol; triacylglycerol; adult; blood; blood analysis; drug implant; female; human; phase 2 clinical trial (topic); procedures; prospective study; young adult; Adult; Blood Chemical Analysis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials, Phase II as Topic; Contraceptive Agents, Female; Drug Implants; Female; Humans; Levonorgestrel; Lipids; Prospective Studies; Triglycerides; Young Adult |
Nature Research |
20452322 |
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34635768 |
Article |
Q1 |
1240 |
3130 |
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57 |
Diptyanusa A., Sari I.P. |
57205340891;57197543698; |
Treatment of human intestinal cryptosporidiosis: A review of published clinical trials |
2021 |
International Journal for Parasitology: Drugs and Drug Resistance |
17 |
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128 |
138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115755098&doi=10.1016%2fj.ijpddr.2021.09.001&partnerID=40&md5=e7d5494025a277d99586bf5f73027625 |
Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia; Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
Diptyanusa, A., Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia, Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis can result in long-term morbidity and high illness costs. The evidence of effective treatments for cryptosporidiosis has been lacking. We reviewed the published clinical trials to bring forward the feasible therapeutic options of human cryptosporidiosis in various populations and settings according to clinical improvement and parasite clearance rates. A total of 42 studies consisting of the use of nitazoxanide, paromomycin, macrolides, somatostatin analogues, letrazuril, albendazole, rifaximin, miltefosine, clofazimine, and colostrum were included in the review. The trials were mostly conducted in small number of individuals infected with human immunodeficiency virus (HIV), and there is inadequate data of controlled trials to suggest the use of these treatment modalities. Nitazoxanide was reported to be highly efficacious only in immunocompetent hosts and was found to be superior to paromomycin in the same group of patients. Macrolides showed no effective results in both clinical and parasitological improvement. Human bovine colostrum should possibly be administered as one of complementary therapeutic modalities along with other antimicrobials to reach optimal parasite eradication. Other trials of therapeutic modalities were terminated due to futility. Currently, available data is intended to aid the development of strategies for improving access to treatments in different clinical settings, as well as to help guide further studies on treatments of human intestinal cryptosporidiosis. © 2021 |
Clearance; Clinical trial; Cryptosporidiosis; Cryptosporidium; Drug; Treatment |
acetylspiramycin; albendazole; alkaline phosphatase; antiparasitic agent; azithromycin; clofazimine; erythromycin; garlicin; immunoglobulin; letrazuril; macrolide; miltefosine; nitazoxanide; octreotide; paromomycin; placebo; probiotic agent; rifaximin; roxithromycin; somatostatin derivative; spiramycin; unclassified drug; vapreotide; antiprotozoal agent; paromomycin; abdominal pain; adolescent; adult; aged; alkaline phosphatase level; alternative medicine; anorexia; antiparasitic therapy; child; cholecystitis; clinical trial (topic); colostrum; constipation; cryptosporidiosis; diarrhea; dizziness; drowsiness; drug efficacy; fatigue; fever; headache; health care access; human; Human immunodeficiency virus infection; hypertransaminasemia; infant; injection site pain; intestine obstruction; k |
Elsevier Ltd |
22113207 |
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34562754 |
Review |
Q1 |
1071 |
3953 |
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58 |
Nugraha R.R., Miranda A.V., Ahmadi A., Lucero-Prisno D.E., III |
57264816700;57222664687;57219362523;56051373800; |
Accelerating Indonesian COVID-19 vaccination rollout: a critical task amid the second wave |
2021 |
Tropical Medicine and Health |
49 |
1 |
76 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115262837&doi=10.1186%2fs41182-021-00367-3&partnerID=40&md5=4ba56c15796323e2ec17398a40768955 |
USAID Health Financing Activity/ThinkWell, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Depok, West Java, Indonesia; Medical Research Center, Kateb University, Kabul, Afghanistan; Department of Public Health, International School of Medicine, Bishkek, Kyrgyzstan; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines (Open University), Los Baños, Laguna, Philippines |
Nugraha, R.R., USAID Health Financing Activity/ThinkWell, Jakarta, Indonesia; Miranda, A.V., Faculty of Medicine, University of Indonesia, Depok, West Java, Indonesia; Ahmadi, A., Medical Research Center, Kateb University, Kabul, Afghanistan, Department of Public Health, International School of Medicine, Bishkek, Kyrgyzstan; Lucero-Prisno, D.E., III, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines (Open University), Los Baños, Laguna, Philippines |
Coronavirus disease-19 (COVID-19) has been spreading in every part of the world, putting nations at risk with its pandemic status, including Indonesia. COVID-19 vaccine has been deemed as one of the most effective interventions to date for mitigating the spread and mortality from COVID-19. Responding to the situation, the Government of Indonesia (GOI) has allocated the means necessary to procure and distribute COVID-19 vaccines; placing into consideration the unique context of the country, recently categorized as a middle-income country and archipelagic with a population over 270 million. This article aims to present the challenges associated with the distribution of COVID-19 vaccination as well as recommendations to mitigate them, to ensure a timely and effective COVID-19 vaccination program in Indonesia. © 2021, The Author(s). |
COVID-19; Indonesia; Pandemic; Recommendations; Second wave; Vaccination |
SARS-CoV-2 vaccine; anti-vaccination movement; coronavirus disease 2019; cryopreservation; decentralization; diplomacy; drug shortage; drug storage; funding; government; human; Indonesia; Letter; pandemic; social responsibility; vaccination; vaccination coverage; vaccine production |
BioMed Central Ltd |
13488945 |
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Letter |
Q2 |
830 |
5753 |
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59 |
Adriansyah I.A., Afriansyah A., Siregar M.A.R., Purnomo N., Mirza H., Seno D.H. |
57255172900;57190688768;57255058200;57255293100;57208513330;57255640300; |
Efficacy of holmium laser enucleation of the prostate in patients with detrusor underactivity: systematic review and meta-analysis |
2021 |
African Journal of Urology |
27 |
1 |
128 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114753119&doi=10.1186%2fs12301-021-00230-1&partnerID=40&md5=a5780c3ae26d7da14412977dd81e01f7 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Salemba, Jakarta Pusat, Jakarta, DKI Jakarta 10430, Indonesia; Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia |
Adriansyah, I.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Salemba, Jakarta Pusat, Jakarta, DKI Jakarta 10430, Indonesia; Afriansyah, A., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Siregar, M.A.R., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Purnomo, N., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Mirza, H., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Seno, D.H., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia |
Background: Benign prostatic hyperplasia (BPH) is commonly found in the aging male. Treatment of BPH can be in form of conservative or surgical intervention. Transurethral resection of the prostate (TURP) is the gold-standard treatment for BPH according to the guideline. However, there is no evidence that there is a benefit for TURP in patients with detrusor underactivity (DUA). Holmium laser enucleation (HoLEP) is theorized to have a better outcome due to its property of complete prostate enucleation. Therefore, this meta-analysis aims to determine the benefit of HoLEP for BPH patients with DUA. Main body: We performed systematic literature searching from five databases including PubMed, Scopus, Embase, Science Direct, and Web of Science for articles up to 31 December 2020 for relevant studies. A total of five articles are eligible for this meta-analysis. A total of 2.180 subjects participated in all of the studies included. Two studies comparing patients with and without DUA that was treated with HoLEP, two studies comparing HoLEP with other surgical approaches for BPH, and one study comparing both parameters. IPSS score reduction is significantly higher in the patients with DUA (Mean Difference = 3.28, 95% CI 1.91 to 4.64, p < 0.01). Qmax and PVR are not significantly different between both groups. HoLEP also showed better improvement in IPSS and Qmax compared to TURP (IPSS: Mean Difference = -4.80, 95% CI − 7.83 to − 1.77, p = 0.002; Qmax: Mean Difference = 4.20, 95% CI 0.58 to 7.82, p = 0.02) and PVP (IPSS: Mean Difference = − 2.47, 95% CI − 4.47 to − 0.47, p = 0.02; Qmax: Mean Difference = 2.31, 95% CI 0.34 to 4.28, p = 0.02). Conclusion: HoLEP showed better improvement in IPSS scores in patients with DUA. HoLEP can be considered to be performed in the BPH patients with DUA for better outcomes for the patients. © 2021, The Author(s). |
Benign prostatic hyperplasia; Detrusor underactivity; HoLEP; Laser enucleation; Surgical outcome |
clinical effectiveness; Embase; enucleation; human; hypotonic bladder; information retrieval; intermethod comparison; International Prostate Symptom Score; laser surgery; male; measurement; Medline; meta analysis; Newcastle-Ottawa scale; postvoid residual urine volume; prostate hypertrophy; prostate surgery; randomized controlled trial (topic); Review; ScienceDirect; Scopus; surgical approach; systematic review; transurethral resection; Web of Science |
Springer Science and Business Media Deutschland GmbH |
11105704 |
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Review |
Q4 |
174 |
21103 |
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60 |
Satjakoesoemah A.I., Alfarissi F., Wahyudi I., Rodjani A., Rasyid N. |
57189614677;57197871808;36341995300;6504653529;56245069300; |
Factors related to the success rate of pediatric extracorporeal shock wave lithotripsy (ESWL) in Cipto Mangunkusumo Hospital: an 8-year single-center experience |
2021 |
African Journal of Urology |
27 |
1 |
92 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114055813&doi=10.1186%2fs12301-021-00187-1&partnerID=40&md5=a186e20e8260339cc3e9b7f5ff9c9867 |
Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia |
Satjakoesoemah, A.I., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia; Alfarissi, F., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia; Wahyudi, I., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia; Rodjani, A., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia |
Background: ESWL is still considered as the first favorable therapeutic option for urinary stone disease with acceptable effectivity. However, factors associated with favorable outcome have not been widely studied in pediatrics due to the small number of urinary stone prevalence. The aim of this study is to evaluate the factors associated with the success rate of pediatric ESWL in our center according to immediate stone-free rate and 3-month stone-free rates. Methods: This is a retrospective cohort study of children less than 18 years who had ESWL for urolithiasis from January 2008 until August 2015. Patient’s characteristics including age, gender, BMI, stone location, stone length, stone burden, stone opacity, and number of ESWL sessions were gathered from the medical record. Nutritional status was determined according to the Centers for Disease Control and Prevention BMI curve. The outcome of this study was the factors related to the success rate in pediatric ESWL. Results: Extracorporeal shock wave lithotripsy was done for 36 patients and 39 renal units (RUs) with mean age of 13.7 ± 4.3 years old, height of 1480 ± 16.0 cm, and BMI of 20.0 ± 3. Of 36 patients included, 39 renoureteral units (RUs) and 46 ESWL sessions were recorded. The mean overall treatment was 1.2 ± 0.5 sessions with mean stone length of 11.1 ± 6.3 mm and stone burden of 116.6 ± 130.3 mm2. Within 3 months of follow-up, we recorded that the overall 3-month success rate was 100%, while the overall 3-month stone-free rate was 66.7%. Stone length (p < 0.001 and p < 0.001), stone perpendicular length (p < 0.001 and p < 0.001), and stone burden (p < 0.001 and p = 0.001) were found to be significantly associated with immediate success and 3-month stone-free status, respectively. Conclusions: ESWL is an effective and safe modality to treat pediatric urolithiasis cases. Stone length, stone perpendicular length, and stone burden were found to be associated with immediate success and 3-month stone-free status after pediatric ESWL treatment. © 2021, The Author(s). |
ESWL; Pediatric; Stone-free rate; Success rate; Urinary stone disease; Urolithiasis |
adolescent; age; Article; body mass; clinical article; cohort analysis; evaluation study; extracorporeal shock wave lithotripsy; factor analysis; female; follow up; gender; hospital; human; male; nutritional status; outcome assessment; public health service; retrospective study; urolithiasis |
Springer Science and Business Media Deutschland GmbH |
11105704 |
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Article |
Q4 |
174 |
21103 |
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