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61 |
Sukrisman L. |
8661764000; |
Soluble P-selectin and correlation with Prothrombin Fragment 1 + 2 in myeloid malignancies in Cipto Mangunkusumo general hospital |
2021 |
Thrombosis Journal |
19 |
1 |
51 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111667161&doi=10.1186%2fs12959-021-00307-5&partnerID=40&md5=29949e22d24b9e6bcdb419fb321d6664 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Sukrisman, L., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Myeloid cells express microparticles that could increase the expression of adhesion molecules including P-selectin. We aimed to evaluate the level of soluble P-selectin (sP-selectin) and prothrombin fragment 1 + 2 (F1 + 2), and to determine correlation of sP-selectin with leukocyte count and F1 + 2 levels in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients. Methods: Patients with newly diagnosed AML (n = 25), CML (n = 13), and controls (n = 17) were recruited in this study. The diagnosis of AML and CML is based on 2001 WHO and/or FAB criteria. Levels of sP-selectin and F1 + 2 were determined using enzyme-linked immunosorbent assay kits (Behring ELISA Processor-III® and Behring Enzygnost F1 + 2). Results: sP-selectin was significantly elevated in CML patients compared to AML patients (p = 0.001). Levels of F1 + 2 in AML and CML patients were significantly increased in comparison to controls (p < 0.001 and p = 0.043). Levels of sP-selectin were significantly correlated to leukocyte count (r = 0.437; p = 0.029) and F1 + 2 (r = 0.436; p = 0.029) in AML patients. Conclusions: AML and CML patients had an increased tendency to thrombosis. While CML patients had higher platelet and/or endothelial activation, hypercoagulable state are more pronounced in AML patients. © 2021, The Author(s). |
AML; CML; F1 + 2; sP-selectin |
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BioMed Central Ltd |
14779560 |
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Article |
Q2 |
1004 |
4364 |
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62 |
Prasetyo M., Mongan A.E., Chozie N.A., Prihartono J., Setiawan S.I. |
57192905252;57226385960;57194329830;6602605635;57195939543; |
Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence |
2021 |
Insights into Imaging |
12 |
1 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111352122&doi=10.1186%2fs13244-021-01050-1&partnerID=40&md5=7acc2e0c4841079a7e9e49379be1ff9e |
Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Departement of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Mongan, A.E., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Chozie, N.A., Department of Pediatric, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Prihartono, J., Departement of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia |
Background: Repeated bleeding in hemophilic arthropathy (HA) may result in severe degenerative changes and joint destruction. The gradient-recalled echo (GRE) sequence MR is proved to be the best method to detect hemosiderin deposition. However, MR is not widely available in developing countries, including Indonesia. Some studies have proposed ultrasonography (US) as an alternative tool in evaluating hemophilic joint. However, there is still some disagreement on the ability of US to detect hemosiderin deposition. Objective: To evaluate the association between US and GRE-sequence MR imaging in detecting hemosiderin deposition in hemophilic ankle joint. Material and methods: A total of 102 sites from 17 ankle joints of 11 boys with severe hemophilia A underwent US examination using a high-frequency linear array transducer. GRE-sequence MR examination was performed in sagittal view consistent with the sites scanned by US. Both examinations were performed on the same day, but MR interpretation was performed blindly at different times. The association between US and GRE-sequences in detecting hemosiderin deposition was analyzed using McNemar’s test. Results: Statistical analysis showed a significant association (p value < 0.001) between US and GRE MR in detecting hemosiderin deposition, but the association is weak (R = 0.26). Sensitivity and specificity of US for detecting hemosiderin deposition were 46.84% (95%CI: 35.51–58.40) and 95.65% (95%CI: 78.05–99.89), respectively, with positive predictive value 97.37% (95%CI: 84.29–99.61), negative predictive value 34.38% (95%CI: 29.50–39.60) and accuracy 57.84% (95%CI: 47.66–67.56). Conclusion: There was a weak association between US and GRE-sequences in detecting hemosiderin deposition of hemophilic ankle joint. © 2021, The Author(s). |
GRE MR imaging; Hemophilic arthropathy; Hemosiderin deposition; US |
gadolinium; hemosiderin; accuracy; adolescent; anisotropy; Article; child; clinical article; cross-sectional study; echography; gradient recalled echo; gray matter; hemophilic arthropathy; histopathology; human; image analysis; male; medial malleolus; nuclear magnetic resonance imaging; predictive value; sensitivity and specificity; synovectomy |
Springer Science and Business Media Deutschland GmbH |
18694101 |
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Article |
Q1 |
1405 |
2531 |
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63 |
Irwinda R., Hiksas R., Siregar A.A., Saroyo Y.B., Wibowo N. |
57190855256;57226152029;57226157581;57164888400;15049026900; |
Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study |
2021 |
Scientific Reports |
11 |
1 |
14701 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110662198&doi=10.1038%2fs41598-021-93846-w&partnerID=40&md5=f379da0f3a9e78e16af9cc0ca6bb9968 |
Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Siregar, A.A., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Long-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status. © 2021, The Author(s). |
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unsaturated fatty acid; adult; blood; case control study; cross-sectional study; female; human; Indonesia; male; newborn; nutritional status; pathology; preeclampsia; pregnancy; prematurity; severity of illness index; young adult; Adult; Case-Control Studies; Cross-Sectional Studies; Fatty Acids, Unsaturated; Female; Humans; Indonesia; Infant, Newborn; Male; Nutritional Status; Pre-Eclampsia; Pregnancy; Premature Birth; Severity of Illness Index; Young Adult |
Nature Research |
20452322 |
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34282168 |
Article |
Q1 |
1240 |
3130 |
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64 |
Syam A.F., Waskito L.A., Rezkitha Y.A.A., Simamora R.M., Yusuf F., Danchi K.E., Bakry A.F., Arnelis, Mulya E., Siregar G.A., Sugihartono T., Maulahela H., Doohan D., Miftahussurur M., Yamaoka Y. |
8443384400;57192177367;56543533600;57224324158;57192179254;57224323695;57207620839;46061818500;57224321810;56483277100;57194156387;57189612709;57204644036;56323903000;55183784100; |
Helicobacter pylori in the Indonesian Malay’s descendants might be imported from other ethnicities |
2021 |
Gut Pathogens |
13 |
1 |
36 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107355307&doi=10.1186%2fs13099-021-00432-6&partnerID=40&md5=50dff7290d04b23d89863e54b90dceb8 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-Cipto Mangunkusumo Teaching Hospital, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Dr. Zainoel Abidin General Hospital, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Internal Medicine, Dr. M Thomsen Nias Gunungsitoli General Hospital, Nias, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Internal Medicine, Cimacan General Hospital, Cianjur, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara, Medan, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr Soetomo Teaching Hospital, Universitas Airlangga, Jalan Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, 60286, Indonesia; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama Machi, Yufu City, Oita, 879-5593, Japan; Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States |
Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-Cipto Mangunkusumo Teaching Hospital, University of Indonesia, Jakarta, Indonesia; Waskito, L.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia, Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia; Simamora, R.M., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Yusuf, F., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Dr. Zainoel Abidin General Hospital, Universitas Syiah Kuala, Banda Aceh, Indonesia; Danchi, K.E., Department of Internal Medicine, Dr. M Thomsen Nias Gunungsitoli General Hospital, Nias, Indonesia; Bakry, A.F., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Arnelis, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Mulya, E., Department of Internal Medicine, Cimacan General Hospital, Cianjur, Indonesia; Siregar, G.A., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara, Medan, Indonesia; Sugihartono, T., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr Soetomo Teaching Hospital, Universitas Airlangga, Jalan Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, 60286, Indonesia; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-Cipto Mangunkusumo Teaching Hospital, University of Indonesia, Jakarta, Indonesia; Doohan, D., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Miftahussurur, M., Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr Soetomo Teaching Hospital, Universitas Airlangga, Jalan Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, 60286, Indonesia; Yamaoka, Y., Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama Machi, Yufu City, Oita, 879-5593, Japan, Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States |
Background: Even though the incidence of H. pylori infection among Malays in the Malay Peninsula is low, we observed a high H. pylori prevalence in Sumatra, which is the main residence of Indonesian Malays. H. pylori prevalence among Indonesian Malay descendants was investigated. Results: Using a combination of five tests, 232 recruited participants were tested for H- pylori and participants were considered positive if at least one test positive. The results showed that the overall H. pylori prevalence was 17.2%. Participants were then categorized into Malay (Aceh, Malay, and Minang), Java (Javanese and Sundanese), Nias, and Bataknese groups. The prevalence of H. pylori was very low among the Malay group (2.8%) and no H. pylori was observed among the Aceh. Similarly, no H. pylori was observed among the Java group. However, the prevalence of H. pylori was high among the Bataknese (52.2%) and moderate among the Nias (6.1%). Multilocus sequence typing showed that H. pylori in Indonesian Malays classified as hpEastAsia with a subpopulation of hspMaori, suggesting that the isolated H. pylori were not a specific Malays H. pylori. Conclusions: Even though the ethnic groups live together as a community, we observed an extremely low H. pylori infection rate among Indonesian Malay descendants with no specific Indonesian Malay H. pylori. The results suggest that H. pylori was not originally among these groups and H. pylori was imported from other ethnic groups. © 2021, The Author(s). |
Epidemiology; Helicobacter pylori; Malays; Population genetics; Prevalence; Sumatra |
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BioMed Central Ltd |
17574749 |
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Article |
Q2 |
1026 |
4226 |
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65 |
Setiawan E.A., Rianda D., Kadim M., Meilianawati, Susanto F., Kok F.J., Shankar A.H., Agustina R. |
57214103232;57214119630;26644177600;57224214324;57224212671;56506613800;7005442634;57214141404; |
Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence |
2021 |
Scientific Reports |
11 |
1 |
11860 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107265110&doi=10.1038%2fs41598-021-88819-y&partnerID=40&md5=ffa4a369e5635d1edafff9d5559b7d3c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Setiawan, E.A., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Rianda, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kadim, M., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Meilianawati, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Susanto, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Kok, F.J., Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Shankar, A.H., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Microbiota and its modification with specific probiotics in early life could provide long term health benefits. Probiotics and calcium strengthen intestinal integrity and may support linear growth. This study investigated the long-term effects of childhood probiotics and calcium supplementation on growth in adolescence. We re-enrolled 238 adolescents aged 11–18 years from 494 children 10-years after 6-months of supplementation with either low-lactose milk fortified with low levels of calcium (LC, ∼50 mg/day, n = 53/124), with regular levels of calcium (RC, ∼440 mg/day, n = 70/126), or with regular calcium + 5 x 108 CFU/day Lactobacillus reuteri DSM 17938 (Reuteri, n = 55/124), or regular calcium + 5 x 108 CFU/day L. casei CRL 431 (Casei, n = 60/120). Changes in height-for-age z-score (HAZ) and body mass index-for-age z-score (BMIZ) were determined from the end of intervention to re-enrollment. General linear models were used to assess the effects on HAZ and BMIZ of group, gender, living area, maternal education, family income, physical activity, diet quality, nutritional status, and gut integrity as determined by urinary lactulose/mannitol ratio (L:M). Adolescent mean age was 15.3 years, mean HAZ was − 1.11, mean BMIZ was − 0.2 and median L:M (n = 155) was 0.23. Changes in HAZ and BMIZ were not significantly different between Casei, Reuteri, LC compared to RC. However, a significant decrease in BMIZ was observed among female adolescents in the Casei compared to RC group (− 0.5 SD, 95% CI − 0.8 to − 0.003, p = 0.048). Childhood probiotic and calcium supplementation may therefore selectively affect female adolescents. Clinical trial registration: This follow-up study has been registered at www.clinicaltrials.gov, Registry name: Rina Agustina, Registration number: NCT04046289, First Registration Date 06/08/19. web link: https://www.clinicaltrials.gov/ct2/show/NCT04046289. © 2021, The Author(s). |
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lactulose; mannitol; probiotic agent; administration and dosage; adolescent; body height; body mass; body weight; calcium intake; controlled study; diet therapy; dietary supplement; double blind procedure; epidemiology; female; follow up; fortified food; health auxiliary; human; Indonesia; Lactobacillus casei; Lactobacillus reuteri; male; nutritional status; randomized controlled trial; risk factor; statistical model; Adolescent; Body Height; Body Mass Index; Body Weight; Calcium, Dietary; Community Health Workers; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies; Food, Fortified; Humans; Indonesia; Lactobacillus casei; Lactobacillus reuteri; Lactulose; Linear Models; Male; Mannitol; Nutrition Therapy; Nutritional Status; Probiotics; Risk Factors |
Nature Research |
20452322 |
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34088920 |
Article |
Q1 |
1240 |
3130 |
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66 |
Pranata R., Yonas E., Huang I., Lim M.A., Nasution S.A., Kuswardhani R.A.T. |
57201973901;57201987097;57208576645;57216039756;57189373134;36863900500; |
Fibrosis-4 index and mortality in coronavirus disease 2019: a meta-analysis |
2021 |
European journal of gastroenterology & hepatology |
33 |
1S Suppl 1 |
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e368 |
e374 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107230733&doi=10.1097%2fMEG.0000000000002091&partnerID=40&md5=ea06112f412d95910a1757cc5756c08a |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSIJakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSIJakarta, Indonesia; Huang, I., Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Nasution, S.A., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Kuswardhani, R.A.T., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Indonesia |
BACKGROUND/AIMS: In this meta-analysis, we aimed to evaluate the prognostic value of fibrosis-4 index (FIB-4) in COVID-19. METHODS: We performed a comprehensive literature search of PubMed, Embase, and Scopus databases on 26 November 2020. FIB-4 was calculated by [age (years) × AST (IU/L)]/[platelet count (109/L) × √ALT (U/L)]. A value above cutoff point was considered high and a value below cutoff point was considered low. The main outcome was mortality, the association between high FIB-4 and mortality was reported in odds ratio (OR). Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic OR (DOR), area under the curve (AUC) were generated. RESULTS: There were 963 patients from five studies included in this systematic review and meta-analysis. Meta-analysis showed that high FIB-4 was associated with increased mortality [OR 3.96 (2.16-7.27), P < 0.001; I2: 41.3%]. High FIB-4 was associated mortality with a sensitivity of 0.56 (0.40-0.70), specificity of 0.80 (0.72-0.86), PLR 2.8 (1.8-4.2), NLR 0.55 (0.39-0.78), DOR 5 (2-10), and AUC of 0.77 (0.73-0.81). Fagan's nomogram indicated that for a pre-test probability (mortality) of 30%, a high FIB-4 was associated with 54% post-test probability and a low FIB-4 was associated with 19%, respectively. The funnel-plot analysis was asymmetrical, trim-and-fill analysis by imputation of a study on the left side using linear estimator resulted in an OR of 3.48 (1.97-6.14). Egger's test showed no indication of small-study effects (P = 0.881). CONCLUSION: High FIB-4 was associated with mortality in patients with COVID-19. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. |
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area under the curve; fibrosis; human; meta analysis; platelet count; Area Under Curve; COVID-19; Fibrosis; Humans; Platelet Count; SARS-CoV-2 |
NLM (Medline) |
14735687 |
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35048648 |
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#N/A |
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67 |
Liem J.F., Mansyur M., Soemarko D.S., Kekalih A., Subekti I., Suyatna F.D., Suryandari D.A., Malik S.G., Pangaribuan B. |
57224169741;37085506800;57192889490;55633562200;24336854300;56039633100;6505763338;7402973374;54785015100; |
Cumulative exposure characteristics of vegetable farmers exposed to Chlorpyrifos in Central Java – Indonesia; a cross-sectional study |
2021 |
BMC Public Health |
21 |
1 |
1066 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107125504&doi=10.1186%2fs12889-021-11161-5&partnerID=40&md5=9fb7a1aa16134c6ee9e3e23e6280115f |
Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Liem, J.F., Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Mansyur, M., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Soemarko, D.S., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Kekalih, A., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Subekti, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suyatna, F.D., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Pangaribuan, B., Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Background: Agriculture is a major economic sector in Indonesia. Chemical pesticides are widely being used in agriculture for controlling pest. There is a growing concern that pesticide exposure, particularly chlorpyrifos (CPF) exposure, combined with other occupational characteristics that determine the level of exposure, can lead to further health impacts for farmers. Our objective was to evaluate the cumulative exposure characteristics among farmers exposed to CPF by using a validated algorithm. Methods: We conducted a cross-sectional study of 152 vegetable farmers aged 18–65 who actively used CPF for at least 1 year in Central Java, Indonesia. Subject characteristics were obtained using a structured interviewer-administered questionnaire, addressed for sociodemographic and work-related characteristics. The cumulative exposure level (CEL) was estimated as a function of the intensity level of pesticide exposure (IL), lifetime years of pesticide use and the number of days spraying per year. CEL was subsequently classified into two groups, high and low exposure groups. The difference in characteristics of the study population was measured using Chi-square, independent-t or Mann-Whitney test. Association between CEL and its characteristics variables were performed by multiple linear regression. Results: Seventy-one subjects (46.7%) were classified as the high exposure group. The use of multiple pesticide mixtures was common among our study population, with 94% of them using 2 or more pesticides. 73% reported direct contact with concentrated pesticides product, and over 80% reported being splashed or spilt during preparation or spraying activity. However, we found that the proportion of proper personal protective equipment (PPE) use in our subjects was low. Higher volume of mixture applied (p < 0.001) and broader acres of land (p = 0.001) were associated with higher cumulative exposure level, while using long-sleeved clothes and long pants (p < 0.05) during pesticide spraying were associated with lower cumulative exposure after adjusted for age and gender. Conclusions: These findings indicate an inadequate knowledge of using pesticides properly. Thus, we recommend comprehensive training on pesticide usage and encourage proper PPE to reduce the exposure level. © 2021, The Author(s). |
Exposure assessment; Exposure reduction; Occupational characteristics; Pesticide cumulative exposure; Work practices |
chlorpyrifos; pesticide; adverse event; agricultural worker; agriculture; cross-sectional study; epidemiology; human; Indonesia; occupational exposure; vegetable; Agriculture; Chlorpyrifos; Cross-Sectional Studies; Farmers; Humans; Indonesia; Occupational Exposure; Pesticides; Vegetables |
BioMed Central Ltd |
14712458 |
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34090393 |
Article |
Q1 |
1230 |
3166 |
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68 |
Yunihastuti E., Amelia F., Hapsari A.I., Wicaksana B., Natali V., Widhani A., Sulaiman A.S., Karjadi T.H. |
57221273925;57216937074;57224070662;57216937319;57216936185;57202561455;57216938482;57219422563; |
Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus |
2021 |
Health and Quality of Life Outcomes |
19 |
1 |
154 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106964144&doi=10.1186%2fs12955-021-01777-x&partnerID=40&md5=2f9401a263635d553b2c13c95a895839 |
Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia; HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hepatobilliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yunihastuti, E., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Amelia, F., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hapsari, A.I., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Wicaksana, B., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Natali, V., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Widhani, A., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Sulaiman, A.S., Hepatobilliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karjadi, T.H., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia |
Background: We conducted a real-life study of health-related quality of life (HRQoL) transformation before and 12 weeks after sofosbuvir and daclatasvir therapy in HCV/HIV co-infected patients. Factors related to the significant changes of each HRQoL domain/item were also evaluated. Methods: A prospective study was performed in the HIV integrated clinic at Cipto Mangunkusumo Hospital, Jakarta. HCV/HIV co-infected patients who started sofosbuvir and daclatasvir from government free DAA program in 2017–2019. WHOQoL-HIV BREF and RAND SF-36 questionnaires were recorded at baseline and post-treatment week 12. Results: 145 patients with mean age of 37.8 years (SD = 4.2) were included in the analysis. Most of patients were male (89%), previous IVDU (89%), active smoker (50.4%) and non-cirrhosis (80%). SVR12 was achieved in 95.5% of patients. Sofosbuvir and daclatasvir treatments showed positive impacts on 2 domains and 2 other items of WHOQoL-HIV BREF and 2 domains and 1 item of SF-36. Predicting factors of significant increase in each domain/item were: male and normal body mass index (BMI) for level of independence (RR 4.01,95% CI 1.09–14.74 and 4.80,95% CI 1.79–12.81); higher HCV-RNA for overall perception of QoL (RR 0.42,95% CI 0.18–0.94); non-smoking status for overall perception of health (RR 0.32,95% CI 0.15–0.66); male and fibrosis stage 0–1 for general health (RR 6.21,95% CI 1.69–22.88 and 2.86,95% CI 1.16–7.00); and the use of NNRTI-based ART (RR 5.23, 95% CI 1.16–23.65). Spiritual/personal belief decline was predicted by non-smoking status (RR 0.46, 95% CI 0.23–0.95). Treatment success was not associated with any changes of HR-QoL domain/item. Conclusions: HCV/HIV co-infected patients were successfully treated with sofosbuvir and daclatasvir and experienced improvement of HRQoL 12 weeks after treatment completion. © 2021, The Author(s). |
Daclastavir; HCV; Health-related quality of life; Hepatitis C; HIV; Sofosbuvir |
daclatasvir; efavirenz; nevirapine; nonnucleoside reverse transcriptase inhibitor; sofosbuvir; antivirus agent; carbamic acid derivative; imidazole derivative; pyrrolidine derivative; sofosbuvir; valine; adult; age; antiretroviral therapy; Article; attitude to health; body mass; cohort analysis; coinfection; controlled study; current smoker; drug effect; drug use; female; general condition improvement; government regulation; health program; hepatitis C; Hepatitis C virus; human; Human immunodeficiency virus; Human immunodeficiency virus infection; liver cirrhosis; major clinical study; male; non-smoker; observational study; patient care; prediction; prospective study; quality of life; Short Form 36; sustained virologic response; treatment duration; treatment outcome; chronic hepatitis C; c |
BioMed Central Ltd |
14777525 |
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34039353 |
Article |
Q1 |
1084 |
3877 |
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69 |
Tamara A., Coulson D.J., Latief J.S., Bakhashab S., Weaver J.U. |
57205305387;57219221240;57219224500;56418579000;57203055590; |
Upregulated anti-angiogenic miR-424-5p in type 1 diabetes (model of subclinical cardiovascular disease) correlates with endothelial progenitor cells, CXCR1/2 and other parameters of vascular health |
2021 |
Stem Cell Research and Therapy |
12 |
1 |
249 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105816910&doi=10.1186%2fs13287-021-02332-7&partnerID=40&md5=90e29bc673c4921f95cd1f09971c9525 |
Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 80218, Saudi Arabia; Department of Diabetes, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, NE9 6SH, United Kingdom; Vascular Biology and Medicine Theme, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom |
Tamara, A., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Coulson, D.J., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom; Latief, J.S., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Bakhashab, S., Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 80218, Saudi Arabia; Weaver, J.U., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Department of Diabetes, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, NE9 6SH, United Kingdom, Vascular Biology and Medicine Theme, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom |
Background: In spite of clinical progress, cardiovascular disease (CVD) remains the predominant cause of mortality worldwide. Overexpression studies in animals have proven miR-424-5p to have anti-angiogenic properties. As type 1 diabetes mellitus (T1DM) without CVD displays endothelial dysfunction and reduced circulating endothelial progenitor cells (cEPCs), it offers a model of subclinical CVD. Therefore, we explored miR-424-5p, cytokines and vascular health in T1DM. Methods: Twenty-nine well-controlled T1DM patients with no CVD and 20-matched controls were studied. Cytokines IL8, TNF-α, IL7, VEGF-C, cEPCs/CD45dimCD34+CD133+ cells and ex-vivo proangiogenic cells (PACs)/fibronectin adhesion assay (FAA) were measured. MiR-424-5p in plasma and peripheral blood mononuclear cells (PBMC) along with mRNAs in PBMC was evaluated. Results: We found an elevation of IL7 (p = 0.008), IL8 (p = 0.003), TNF-α (p = 0.041), VEGF-C (p = 0.013), upregulation of mRNA CXCR1 (p = 0.009), CXCR2 (p < 0.001) and reduction of cEPCs (p < 0.001), PACs (p < 0.001) and FAA (p = 0.017) in T1DM. MiR-424-5p was upregulated in T1DM in PBMC (p < 0.001). MiR-424-5p was negatively correlated with cEPCs (p = 0.006), PACs (p = 0.005) and FAA (p < 0.001) and positively with HbA1c (p < 0.001), IL7 (p = 0.008), IL8 (p = 0.017), VEGF-C (p = 0.007), CXCR1 (p = 0.02) and CXCR2 (p = 0.001). ROC curve analyses showed (1) miR-424-5p to be a biomarker for T1DM (p < 0.001) and (2) significant upregulation of miR-424-5p, defining subclinical CVD, occurred at HbA1c of 46.5 mmol/mol (p = 0.002). Conclusion: We validated animal research on anti-angiogenic properties of miR-424-5p in T1DM. MiR-424-5p may be a biomarker for onset of subclinical CVD at HbA1c of 46.5 mmol/mol (pre-diabetes). Thus, miR-424-5p has potential use for CVD monitoring whilst anti-miR-424-5p-based therapies may be used to reduce CVD morbidity/mortality in T1DM. © 2021, The Author(s). |
CD45dimCD34+CD133+, CXCR1/2; IL8; MiR-424-5p; T1DM |
alanine aminotransferase; biological marker; CD133 antigen; CD34 antigen; CD40 antigen; chemokine receptor CXCR1; chemokine receptor CXCR2; complementary DNA; cyclin D1; cyclooxygenase 2; endothelial leukocyte adhesion molecule 1; fibroblast growth factor 2; gamma interferon inducible protein 10; glucose; hemoglobin A1c; interleukin 10; interleukin 16; interleukin 7; interleukin 8; messenger RNA; microRNA; microRNA 424 5p; PADGEM protein; platelet derived growth factor AA; receptor type tyrosine protein phosphatase C; somatomedin C; tissue inhibitor of metalloproteinase 1; triacylglycerol; tumor necrosis factor; unclassified drug; vasculotropin C; microRNA; MIRN424 microrna, human; adult; alanine aminotransferase blood level; Article; cardiovascular disease; cardiovascular risk; clinical a |
BioMed Central Ltd |
17576512 |
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33985567 |
Article |
Q1 |
1599 |
2021 |
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70 |
Hariyanto H., Yahya C.Q., Aritonang R.C.A. |
55906967200;57190857039;57219610092; |
Severe COVID-19 in the intensive care unit: a case series |
2021 |
Journal of Medical Case Reports |
15 |
1 |
259 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105198319&doi=10.1186%2fs13256-021-02799-1&partnerID=40&md5=e5b4ca83dd05aec07a1a292f27fde4db |
Faculty of Medicine, Department of Anesthesiology and Intensive Care, Universitas Pelita Harapan, Jl. M. H. Thamrin Boulevard 1100, Lippo Village Tangerang, Tangerang, Banten 15811, Indonesia; Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No 77, Jakarta Pusat, 10430, Indonesia; Siloam Hospitals Kelapa Dua, Jl. Kelapa Dua Raya No.1001, Kelapa Dua, Tangerang, Banten 15810, Indonesia |
Hariyanto, H., Faculty of Medicine, Department of Anesthesiology and Intensive Care, Universitas Pelita Harapan, Jl. M. H. Thamrin Boulevard 1100, Lippo Village Tangerang, Tangerang, Banten 15811, Indonesia, Siloam Hospitals Kelapa Dua, Jl. Kelapa Dua Raya No.1001, Kelapa Dua, Tangerang, Banten 15810, Indonesia; Yahya, C.Q., Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No 77, Jakarta Pusat, 10430, Indonesia; Aritonang, R.C.A., Faculty of Medicine, Department of Anesthesiology and Intensive Care, Universitas Pelita Harapan, Jl. M. H. Thamrin Boulevard 1100, Lippo Village Tangerang, Tangerang, Banten 15811, Indonesia, Siloam Hospitals Kelapa Dua, Jl. Kelapa Dua Raya No.1001, Kelapa Dua, Tangerang, Banten 15810, Indonesia |
Background: Coronavirus disease 2019 (COVID-19) was first identified in Indonesia in March 2020, and the number of infections has grown exponentially. The situation is at its worst, overwhelming intensive care unit (ICU) resources and capacity. Case presentation: This is a single-center observational case study of 21 confirmed COVID-19 patients admitted to the ICU from March 20, 2020, to April 31, 2020. Demographics, baseline comorbidities, clinical symptoms, laboratory tests, electrocardiogram (ECG) and chest imaging were obtained consecutively during patient care. We identified 21 patients with confirmed COVID-19 severe infection in our ICU. The mean (± standard deviation) age of the patients was 54 ± 10 years; 95% were men, with shortness of breath (90.6%) the most common symptom. Hypertension was identified as a comorbidity in 28.6% of patients. The most common reason for admission to the ICU was hypoxemic respiratory failure, with 80% (17 patients) requiring mechanical ventilation. Half of the patients (10) died between day 1 and day 18, with septic shock as the primary cause of death. Of the 11 surviving patients, five were discharged home, while six were discharged from the ICU but remained in the hospital ward. Even then, the median length of ICU stay amongst survivors was 18 days. Conclusions: To date, there are no known effective antiviral agents or specific therapy to treat COVID-19. As severe systemic inflammatory response and multiple organ failure seems to be the primary cause of death, supportive care in maintaining oxygenation and hemodynamic stability remain the mainstay goals in treating critically ill COVID-19 patients. © 2021, The Author(s). |
Case report; COVID-19; ICU; Mechanical ventilation; Respiratory failure; Septic shock; Severe infection |
alanine aminotransferase; antifungal agent; aspartate aminotransferase; azithromycin; C reactive protein; heparin; hydroxychloroquine; lactate dehydrogenase; meropenem; tocilizumab; adult; aged; alanine aminotransferase blood level; Article; artificial ventilation; aspartate aminotransferase blood level; case study; cause of death; clinical article; clinical feature; comorbidity; computer assisted tomography; coronavirus disease 2019; coughing; critically ill patient; disease duration; disease severity; dyspnea; electrocardiogram; erythrocyte sedimentation rate; fatigue; female; fever; ground glass opacity; hospital admission; hospital discharge; human; hypertension; hypoxemic respiratory failure; Indonesia; intensive care unit; intubation; laboratory test; lactate dehydrogenase blood leve |
BioMed Central Ltd |
17521947 |
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33941249 |
Article |
Q3 |
287 |
15275 |
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