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No records
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234 |
Nugroho S.W., Pradhana I., Gunawan K. |
57460519700;57373805000;57195935319; |
New adaptation of neurosurgical practice and residency programs during the Covid-19 pandemic and their effects on neurosurgery resident satisfaction and welfare at the National General Hospital, Jakarta, Indonesia |
2021 |
Heliyon |
7 |
8 |
e07757 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121271314&doi=10.1016%2fj.heliyon.2021.e07757&partnerID=40&md5=09cbd414f0eefb36b6d98b642efa84cf |
Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Nugroho, S.W., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pradhana, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gunawan, K., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Many institutions in numerous countries have made changes in their health care services during the COVID-19 pandemic. One change has been to reduce elective neurosurgery cases, which has impacted neurosurgery education. Published literature is lacking about the healthcare services, education, and residents’ well-being during adaptation to the pandemic, especially in national referral hospitals in developing countries. Methods: We conducted a cross-sectional study on current neurosurgical services during 2020. We evaluated 34 neurosurgery residents in Cipto Mangunkusumo National General Hospital using a self-made questionnaire to determine the effects of the COVID-19 pandemic on their surroundings, education process, and satisfaction with the currently adapted education program. We used the modified Maslach Burnout Inventory to assess burnout in the residents before and during the pandemic. Results: Neurosurgical residents spent more time studying neurosurgical theory (Mode 1–1.5h/day, p < 0.05) but spent less time learning neurosurgical skills (Mode 30 min–1 h/day, p < 0.05) compared to before the pandemic. The resident satisfaction mean score (scale 0–10) was 7.58 for live surgery and 8.53 for the microsurgical skills lab training program. On a scale of 1–10, the residents’ stress level increased after the pandemic but the change was not statistically significant (6.61 ± 1.87, p > 0.05). The Modified Maslach Burnout inventory score was 3.02 ± 3.74 during the pandemic, and increased from before the pandemic (2.41 ± 3.18), but the difference was not statistically significant. Conclusion: The COVID-19 pandemics have reduced the working hours and the clinical exposure of neurosurgical residents. Fortunately, this pandemic has led to a new opportunity to find many suitable learning methods which may decrease the risk of burnout. The psychological burden of residents is still worrisome, and planned management is necessary to sustain resident performance. © 2021 |
COVID-19; Education; Neurosurgery; Neurosurgical residency; Pandemic; Residency |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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236 |
Lancaster K.E., Mollan K.R., Hanscom B.S., Shook-Sa B.E., Ha T.V., Dumchev K., Djoerban Z., Rose S.M., Latkin C.A., Metzger D.S., Go V.F., Dvoriak S., Reifeis S.A., Piwowar-Manning E.M., Richardson P., Hudgens M.G., Hamilton E.L., Eshleman S.H., Susami H., Chu V.A., Djauzi S., Kiriazova T., Nhan D.T., Burns D.N., Miller W.C., Hoffman I.F. |
55503210000;26659057900;6603650318;55990940100;36988527800;8923601900;23472548200;12544917400;57235096800;35944632400;7102536801;57205192774;57193208279;35783326900;57203639655;6603567044;56450237600;7004740977;57202642757;57195576444;23495847800;55757875500;57317058700;7403171278;7406061778;7006682600; |
Engaging People Who Inject Drugs Living with HIV in Antiretroviral Treatment and Medication for Opioid Use Disorder: Extended Follow-up of HIV Prevention Trials Network (HPTN) 074 |
2021 |
Open Forum Infectious Diseases |
8 |
8 |
ofab281 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118242331&doi=10.1093%2fofid%2fofab281&partnerID=40&md5=6133eea6e10cff9e76240789c9b5b783 |
Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; UNC Vietnam, Hanoi, Viet Nam; Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Science Facilitation Department, FHI 360, Durham, NC, United States; Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; HIV Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Academy of Labor, Social Relations and Tourism, Kyiv, Ukraine; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Vietnam Administration of HIV/AIDS Control, Hanoi, Viet Nam; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
Lancaster, K.E., Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Mollan, K.R., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Hanscom, B.S., Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Shook-Sa, B.E., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Ha, T.V., Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, UNC Vietnam, Hanoi, Viet Nam; Dumchev, K., Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Djoerban, Z., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rose, S.M., Science Facilitation Department, FHI 360, Durham, NC, United States; Latkin, C.A., Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; Metzger, D.S., HIV Prevention Research Division, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Go, V.F., Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Dvoriak, S., Academy of Labor, Social Relations and Tourism, Kyiv, Ukraine; Reifeis, S.A., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Piwowar-Manning, E.M., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Richardson, P., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Hudgens, M.G., Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Hamilton, E.L., Science Facilitation Department, FHI 360, Durham, NC, United States; Eshleman, S.H., Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Susami, H., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Chu, V.A., UNC Vietnam, Hanoi, Viet Nam; Djauzi, S., Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kiriazova, T., Ukrainian Institute on Public Health Policy, Kyiv, Ukraine; Nhan, D.T., Vietnam Administration of HIV/AIDS Control, Hanoi, Viet Nam; Burns, D.N., Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Miller, W.C., Division of Epidemiology, College of Public Health, Ohio State University, 1841 Neil Ave, 334 Cunz Hall, Columbus, OH 43210-1351, United States; Hoffman, I.F., Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States |
Background: People who inject drugs (PWID) living with HIV experience inadequate access to antiretroviral treatment (ART) and medication for opioid use disorders (MOUD). HPTN 074 showed that an integrated intervention increased ART use and viral suppression over 52 weeks. To examine durability of ART, MOUD, and HIV viral suppression, participants could re-enroll for an extended follow-up period, during which standard-of-care (SOC) participants in need of support were offered the intervention. Methods: Participants were recruited from Ukraine, Indonesia and Vietnam and randomly allocated 3:1 to SOC or intervention. Eligibility criteria included: HIV-positive; active injection drug use; 18-60 years of age; ≥1 HIV-uninfected injection partner; and viral load ≥1,000 copies/mL. Re-enrollment was offered to all available intervention and SOC arm participants, and SOC participants in need of support (off-ART or off-MOUD) were offered the intervention. Results: The intervention continuation group re-enrolled 89 participants, and from week 52 to 104, viral suppression (<40 copies/mL) declined from 41% to 29% (estimated 9.4% decrease per year, 95% CI-17.0%;-1.8%). The in need of support group re-enrolled 94 participants and had increased ART (re-enrollment: 55%, week 26: 69%) and MOUD (re-enrollment: 16%, week 26: 25%) use, and viral suppression (re-enrollment: 40%, week 26: 49%). Conclusions: Viral suppression declined in year 2 for those who initially received the HPTN 074 intervention and improved maintenance support is warranted. Viral suppression and MOUD increased among in need participants who received intervention during the study extension. Continued efforts are needed for widespread implementation of this scalable, integrated intervention. © 2021 The Author(s). |
antiretroviral therapy; HIV infection; injection drug use; methadone/therapeutic use; viral load |
antiretrovirus agent; buprenorphine; methadone; adult; Article; CD4 lymphocyte count; Consolidated Standards of Reporting Trial; controlled study; disease transmission; epidemic; evaluation and follow up; female; health care quality; health education; hepatitis C; human; Human immunodeficiency virus infection; incidence; injection drug user; integrated health care system; intervention study; interview; major clinical study; male; medication compliance; medication for opioid use disorder; medication for opioid use disorder; middle aged; opiate addiction; outcome assessment; paramedical personnel; practice guideline; psychosocial development; randomized controlled trial; telephone interview; viral suppression; virus load; World Health Organization; young adult |
Oxford University Press |
23288957 |
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Article |
Q1 |
1546 |
2161 |
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237 |
Suhaeri M., Kim Y.-M., Yunarti R.T., Song S.-C. |
56183087500;57294592700;56086215900;7403350156; |
Thermoresponsive and suspension forming cyclotriphosphazene conjugate for delivery vehicle of antitumor drug camptothecin |
2021 |
Journal of Drug Delivery Science and Technology |
64 |
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102049 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116958285&doi=10.1016%2fj.jddst.2020.102049&partnerID=40&md5=e52dca3896e5c2ec2892116e880dc19c |
Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Depok, 16424, Indonesia; Medical Technology Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea; Inorganic Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI Baru, Depok, Jawa Barat 16424, Indonesia; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea |
Suhaeri, M., Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Depok, 16424, Indonesia, Medical Technology Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Kim, Y.-M., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea; Yunarti, R.T., Inorganic Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI Baru, Depok, Jawa Barat 16424, Indonesia; Song, S.-C., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea |
Camptothecin (CPT) has been used as antitumor drug against a wide range of cancer cells. However, its clinical application is greatly hindered by insolubility and instability issues under physiological condition. Therefore, an appropriate CPT administration technique directed for living system is greatly anticipated. In this study, a delivery method for CPT in the form of thermoresponsive system was prescribed. A conjugate of cyclotriphosphazene and CPT was synthesized by substituting hexachlorocyclotriphosphazene with sodium salt of methoxy-poly (ethylene glycol) (Mw = 350), 20-O-trifluoroglycinylCPT, and isoleucine ethyl ester, respectively. The resulting cyclotriphosphazene-CPT was characterized via multinuclear (1H and 31P) NMR as well as FT-IR. The current conjugate showed temperature induced phase transition (solution to suspension) with a lower critical solution temperature at 31 °C. Our result indicated that the stability issue related to the use of CPT in aqueous solution could be handled by acylation at 20-OH moiety. Additionally, antitumor activity of cyclotriphosphazene-CPT, to some extent, was found to be more profound than that of CPT alone as evaluated against human colorectal cancer cell HCT-116. Altogether, the current cyclotriphosphazene-CPT conjugate might offer a facile method in delivering CPT as a minimally invasive system for treating cancer. © 2020 Elsevier B.V. |
Antitumor; Camptothecin; Conjugate; Cyclotriphosphazene; Drug delivery; Thermoresponsive |
camptothecin; hexachlorocyclotriphosphazene; isoleucine; macrogol; polymer; sodium; unclassified drug; antineoplastic activity; Article; critical solution temperature; drug conjugation; drug delivery system; drug structure; drug synthesis; Fourier transform infrared spectroscopy; HCT 116 cell line; human; human cell; phase transition; phosphorus nuclear magnetic resonance; proton nuclear magnetic resonance; temperature |
Editions de Sante |
17732247 |
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Article |
Q2 |
663 |
7562 |
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241 |
Dharmawan Y., Fuady A., Korfage I., Richardus J.H. |
57189353850;37085331400;6506984424;7003977198; |
Individual and community factors determining delayed leprosy case detection: A systematic review |
2021 |
PLoS Neglected Tropical Diseases |
15 |
8 |
e0009651 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114085346&doi=10.1371%2fjournal.pntd.0009651&partnerID=40&md5=cd44ee5b8798b15d9e0def1be72603ab |
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dharmawan, Y., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia; Fuady, A., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Korfage, I., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Richardus, J.H., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands |
Background The number of new leprosy cases is declining globally, but the disability caused by leprosy remains an important disease burden. The chance of disability is increased by delayed case detection. This review focusses on the individual and community determinants of delayed leprosy case detection. Methods This study was conducted according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). The study protocol is registered in PROS-PERO (code: CRD42020189274). To identify determinants of delayed detection, data was collected from five electronic databases: Embase.com, Medline All Ovid, Web of Science, Cochrane CENTRAL, and the WHO Global Health Library. Results We included 27 papers from 4315 records assessed. They originated in twelve countries, had been published between January 1, 2000, and January 31, 2021, and described the factors related to delayed leprosy case detection, the duration of the delayed case, and the percentage of Grade 2 Disability (G2D). The median delay in detection ranged from 12 to 36 months, the mean delay ranged from 11.5 to 64.1 months, and the percentage of G2D ranged from 5.6 to 43.2%. Health-service-seeking behavior was the most common factor associated with delayed detection. The most common individual factors were older age, being male, having a lower disease-symptom perception, having multibacillary leprosy, and lack of knowledge. The most common socioeconomic factors were living in a rural area, perform-ing agricultural labor, and being unemployed. Stigma was the most common social and community factor. Conclusions Delayed leprosy case detection is clearly correlated with increased disability and should therefore be a priority of leprosy programs. Interventions should focus on determinants of delayed case detection such as health-service-seeking behavior, and should consider rele-vant individual, socioeconomic, and community factors, including stigmatization. Further study is required of the health service-related factors contributing to delay. : © 2021 Dharmawan et al. |
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age distribution; attitude to health; awareness; delayed diagnosis; diagnosis time; disability; educational status; geographic distribution; help seeking behavior; human; leprosy; multibacillary leprosy; occupation; Review; risk perception; sex ratio; social belief; social determinants of health; social stigma; socioeconomics; systematic review; unemployment; complication; delayed diagnosis; disabled person; leprosy; patient attitude; psychology; risk factor; time to treatment; Delayed Diagnosis; Disabled Persons; Humans; Leprosy; Patient Acceptance of Health Care; Risk Factors; Social Stigma; Socioeconomic Factors; Time-to-Treatment |
Public Library of Science |
19352727 |
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34383768 |
Review |
Q1 |
1990 |
1322 |
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245 |
Yunihastuti E., Hariyanto R., Sulaiman A.S., Harimurti K. |
57221273925;57226819413;57216938482;23473513200; |
Hepatitis C continuum of care: Experience of integrative hepatitis C treatment within a human immunodeficiency virus clinic in Indonesia |
2021 |
PLoS ONE |
16 |
8 August |
e0256164 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112781600&doi=10.1371%2fjournal.pone.0256164&partnerID=40&md5=97994b56bdf101c196e7c76dcd7be446 |
Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yunihastuti, E., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hariyanto, R., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sulaiman, A.S., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harimurti, K., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction Direct-acting antiviral drugs (DAAs) have changed the paradigm of hepatitis C therapy for both HCV/HIV co-infected and HCV mono-infected patients. We aimed to describe the HCV continuum of care of HIV-infected patients treated in an HIV clinic after a free DAA program in Indonesia and identify factors correlated with sofosbuvir-daclatasvir (SOF-DCV) treatment failure. Methods We did a retrospective cohort study of adult HIV/HCV co-infected patients under routine HIV-care from November 2019 to April 2020 in the HIV integrated clinic of Cipto Mangunkusumo Hospital, Jakarta, Indonesia. We evaluated some factors correlated with sofosbuvir-daclatasvir treatment failure: gender, diabetes mellitus, previous IFN failure, cirrhosis, concomitant ribavirin use, high baseline HCV-RNA, and low CD4 cell count. Results and discussion Overall, 640 anti-HCV positive patients were included in the study. Most of them were male (88.3%) and former intravenous drug users (76.6%) with a mean age of 40.95 (SD 4.60) years old. Numbers and percentages for the stages of the HCV continuum of care were as follows: HCV-RNA tested (411; 64.2%), pre-therapeutic evaluation done (271; 42.3%), HCV treatment initiated (210; 32.8%), HCV treatment completed (207; 32.2%), but only 178 of these patients had follow-up HCV-RNA tests to allow SVR assessment; and finally SVR12 achieved (178; 27.8%). For the 184 who completed SOF-DCV treatment, SVR12 was achieved by 95.7%. In multivariate analysis, diabetes mellitus remained a significant factor correlated with SOF-DCV treatment failure (adjusted RR 17.0, 95%CI: 3.28–88.23, p = 0.001). Conclusions This study found that in the HCV continuum of care for HIV/HCV co-infected patients, gaps still exist at all stages. As the most commonly used DAA combination, sofosbuvir daclatasvir treatment proved to be effective and well-tolerated in HIV/HCV co-infected patients. Diabetes mellitus was significant factor correlated with not achieving SVR12 in this population. © 2021 Yunihastuti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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antiretrovirus agent; daclatasvir; efavirenz; elbasvir plus grazoprevir; interferon; lopinavir plus ritonavir; nevirapine; ribavirin; simeprevir; sofosbuvir; virus RNA; antivirus agent; adult; Article; CD4 lymphocyte count; cohort analysis; coinfection; controlled study; diabetes mellitus; drug withdrawal; fatigue; female; fever; follow up; gastrointestinal disease; gender; headache; hepatitis C; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; Indonesia; injection drug user; liver cirrhosis; major clinical study; male; multivariate analysis; myalgia; nausea; patient care; pruritus; retrospective study; RNA analysis; sleep disorder; sustained virologic response; university hospital; virus load; coinfection; drug effect; Hepacivirus; hepatitis C; |
Public Library of Science |
19326203 |
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34383853 |
Article |
Q1 |
990 |
4434 |
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249 |
Kamal A.F., Ramang D.S. |
56648996700;57195942455; |
A simple management of massive bone defect after en-bloc resection of osteofibrous dysplasia of tibial shaft: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106213 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111724269&doi=10.1016%2fj.ijscr.2021.106213&partnerID=40&md5=fd1f09e882e103495b845ed8ef9477e1 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Kamal, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ramang, D.S., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Osteofibrous dysplasia is a relatively rare disease, exclusively found in children, affecting the tibial diaphysis. Various management approaches are already available, but an internationally approved management guideline is not yet established. There is a major concern in the current management of wide excision technique as it frequently results in massive bone defect. Case presentation: Here we present a case of osteofibrous dysplasia on a 10-year-old girl in Cipto Mangunkusumo Hospital with chief complaint of mild persistent pain of her lower leg since two years before with slight bowing deformity. The radiograph and histopathological examination support the diagnosis of osteofibrous dysplasia. She was managed with en-bloc resection (wide excision) of the tumor, followed with reconstruction using biomaterials substitute; combination between demineralized bone matrix (BonegenerR) and bone substitute “hydroxyapatite and calcium sulphate” and internal fixation using plate and screw. Results: Clinical and radiological evaluation showed successful improvement and outcome. The patient showed progressive functional outcomes and achieved functional score of 100% LEFS at 3 years follow-up. The plate and screw was removed at 48 weeks after adequate callus formation andradiological union was achieved. Conclusion: Simple reconstruction using biomaterial bone substitute not only created new bone formation with good stability, but also enabled patient to have an improved quality of life. This method is recommended to overcome the massive bone defect after tumor resection in osteofibrous dysplasia patient. © 2021 The Author(s) |
Biomaterial; Massive bone defect; Osteofibrous dyplasia; Wide excision |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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250 |
Miraj F., Nugroho A., Dalitan I.M., Setyarani M. |
56471854400;57211502355;57226482440;55883575900; |
The efficacy of ilizarov method for management of long tibial bone and soft tissue defect |
2021 |
Annals of Medicine and Surgery |
68 |
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102645 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111624016&doi=10.1016%2fj.amsu.2021.102645&partnerID=40&md5=90add1d384d132f92b578c2bb65882ad |
Pediatrics Orthopaedics and Limb Reconstruction Division, Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Miraj, F., Pediatrics Orthopaedics and Limb Reconstruction Division, Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Nugroho, A., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dalitan, I.M., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyarani, M., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Patients with open fracture Gustillo-Anderson grade 3 had undergone several surgical procedures, but still ended up with expose long dead bone or infected. Illizarov method was used to address long bone and soft tissue defect after re-debridement with radical resection of long dead bone or infected segment. Methods: We included 14 patients (mean age: 30.86 ± 11.49) with non-union tibial fracture with long dead and infected bone segment who had undergone several debridement, bone grafting or spacer and soft tissue closure procedure due to open fracture of tibia grade 3. The subjects underwent re-debridement with radical resection of dead or infected bone segment followed by Illizarov method to perform bone transport procedure for bone defect filling and simultaneously restore severe soft tissue loss and bone lengthening procedure. Results: All subjects had achieved satisfactory results with mean docking period of bone transport 3.78 ± 0.54 months, union time at the docking side 7 (5.5–9) months. Soft tissue was covered and no recurrence of infection. Three subjects had Leg Length Discrepancy (LLD) of 1 cm, whereas the remaining had zero discrepancy. No significant pain was observed at final follow-up and 4 patients had ankle joint stiffness. Conclusion: The Illizarov method can effectively address long bone and soft tissue defects by distraction osteogenesis through bone transport procedure that filling the defect gradually without bone graft and simultaneously enhancing soft tissue closure without tertiary soft tissue procedure subsequently followed with bone lengthening procedure to correct the limb length discrepancy. © 2021 |
Illizarov method; Long tibial bone defect; Non-union fracture of tibia; Soft tissue defect |
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Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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251 |
Purwoto G., Surya I.U., Saroyo Y.B., Rustamadji P., Harzif A.K. |
14720170400;57226288663;57164888400;55321572200;57191493435; |
Massive obstetric haemorrhage on post caesarean subtotal hysterectomy due to late detection of occult placenta percreta: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106225 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111073049&doi=10.1016%2fj.ijscr.2021.106225&partnerID=40&md5=8fb12792281a054a4a64365989402d15 |
Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia; Department Anatomical Pathology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo, Indonesia |
Purwoto, G., Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia; Surya, I.U., Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia; Saroyo, Y.B., Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia; Rustamadji, P., Department Anatomical Pathology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo, Indonesia; Harzif, A.K., Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Placenta accreta syndrome is a significant cause of maternal mortality and morbidity. Therefore, a multidiscipline approach is essential to overcome this life-threatening disorder for the mother and fetus. Presentation of case: A 32-year-old women gravida 3 parity 2, 34 weeks gestation come due to recurrent antepartum haemorrhage. She had twice prior caesarean section. Ultrasound assessment suggests total placenta previa and elevating suspicion to placenta accreta. However, intraoperatively its sign is unavailable. Although we have done subtotal hysterectomy, massive bleeding still occurring. Therefore, we present management of unexpected placenta percreta. Discussion: Management of unexpected placenta percreta involves prenatal diagnosis, haemoglobin optimization, surgical management anticipating haemorrhage, dedicated maternal ICU, blood bank providing massive transfusion and blood component. Conclusion: Close monitoring is important in catastrophe management of Placenta Accreta Syndrome. © 2021 The Authors |
Case report; Focal placenta accreta; Hypogastric artery ligation; Placenta previa; Villi chorion |
C reactive protein; creatinine; fresh frozen plasma; hemoglobin; procalcitonin; thrombocyte concentrate; urea; adult; amnion fluid; antepartum hemorrhage; artery ligation; Article; blood cell count; breech presentation; broad ligament; case report; cervicotomy; cesarean section; clinical article; diastolic blood pressure; dissection; echography; emergency surgery; erythrocyte count; erythrocyte transfusion; female; fetus heart rate; fetus weight; follow up; hematocrit; hemoglobin blood level; human; hysterectomy; internal iliac artery; intraoperative period; laparotomy; leukocyte count; neutrophil lymphocyte ratio; placenta accreta; placenta previa; plasma transfusion; recurrent disease; round ligament; systolic blood pressure; umbilical artery; uterine atony; uterus contraction; vagina bl |
Elsevier Ltd |
22102612 |
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Q3 |
232 |
17549 |
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253 |
Reksodiputro M.H., Hutauruk S.M., Koento T., Fardizza F., Hakim R.Y.R., Audindra S., Yosia M. |
35090488800;57205105620;35090124600;55091031700;57226286398;57222006228;57204933098; |
Randomised clinical trial: Effect of administering platelet-rich fibrin to autologous fat tissue in injection laryngoplasty for vocal cord paralysis |
2021 |
Annals of Medicine and Surgery |
68 |
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102564 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111006340&doi=10.1016%2fj.amsu.2021.102564&partnerID=40&md5=55d6b3d1b486bec46a872ef4e755dd23 |
Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia |
Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Hutauruk, S.M., Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Koento, T., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Fardizza, F., Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Hakim, R.Y.R., Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Audindra, S., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia |
The vocal cord in humans is essential in producing voice used in communication and interaction between us. Vocal cord paralysis causes dysphonia, which interferes with communication, causing disruptions towards social activity and daily activities. One of the managements for vocal cord paralysis is medialization and augmentation of the vocal cord through injection laryngoplasty. Autologous fat is one of the best fillers used in this procedure, but it is highly absorbable and can be reabsorbed very quickly when injected into body tissues. Platelet Rich Fibrin (PRF) is a biomaterial consisting of growth factors that are thought to improve fat tissue viability by increasing adipogenesis and angiogenesis. Improvement in fat viability will improve clinical outcomes after the laryngoplasty procedure, potentially reducing the number of repeated injections needed to achieve a satisfactory resolution to vocal cord paralysis. The study evaluates a combination of PRF and autologous microlobular fat compared with autologous microlobular fat alone on laryngoplasty. This single-blinded randomised control trial recruit a total of 18 patients, which are then randomised into the treatment and control groups. The evaluation was done via computerized acoustic analysis/Multidimensional Voice Program (MDVP) parameters and maximum phonation time. The MDVP results and maximum phonation time in both groups showed clinical improvement after the operation with no statistically significant differences. © 2021 The Authors |
Autologous fat; Injection laryngoplasty; Platelet-rich fibrin; Vocal cord paralysis |
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Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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254 |
Wahyudi M., Alaztha Z. |
57053464800;57219572320; |
Chondrosarcoma arising in monostotic fibrous dysplasia treated with total femur resection and megaprothesis: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106194 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110717734&doi=10.1016%2fj.ijscr.2021.106194&partnerID=40&md5=45372bc574217c458407b12ac52c18ba |
Department of Orthopaedic and Traumatology, Fatmawati General Hospital, Indonesia; Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia |
Wahyudi, M., Department of Orthopaedic and Traumatology, Fatmawati General Hospital, Indonesia; Alaztha, Z., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Fibrous dysplasia is tumor like lesions of bone which develop as substitution of bone by an expansion of fibrous connective tissue mixed with hard trabeculae. Chondrosarcomas is one of common malignant primary bone tumor derived from heterogenous group of neoplasm producing chondroid matrix. Chondrosarcoma arising in fibrous dysplasia, especially in monostotic fibrous dysplasia is a very rare case. Case report: A 54-year-old male presented with chief complaint of pain on left thigh. Patient with history of pathological fracture on left femoral diaphysis 3 years ago due to fibrous dysplasia and had underwent curettage, open reduction, and internal fixation at other hospital. Plain radiography revealed expansive lytic lesion, interrupted periosteal reaction with plate and screw attached to the lesion, and soft tissue mass. MRI T2FS sequence showed hyperintense mass extending from subtrochanteric to distal of left femoral diaphysis. Histopathological result from biopsy suggested chondrosarcoma. Conclusions: Malignant transformation of monostotic type was less frequently compared to polyostotic type. Among all malignant transformation cases, alteration to chondrosarcoma was more scarce than other malignancy such as osteosarcoma and fibrosarcoma. Wide surgical margin and reconstruction in chondrosarcoma provide good local control and functional outcome. © 2021 The Authors |
Chondrosarcoma; Malignant transformation; Monostotic fibrous dysplasia; Total femur resection |
polyethylene terephthalate; abduction; adult; anamnesis; Article; blood examination; bone biopsy; bone radiography; cancer surgery; cartilage matrix; case report; chondrocyte; chondrosarcoma; clinical article; curettage; femoral shaft; femoral vein; femur; femur diaphysis; femur fracture; femur shaft fracture; follow up; general hospital; greater trochanter; histopathology; human; human cell; incision; laboratory; leg pain; length of stay; male; middle aged; monostotic fibrous dysplasia; nuclear magnetic resonance imaging; open fracture reduction; operative blood loss; orthopedic surgery; osteosynthesis; pathologic fracture; physical examination; psoas muscle; rectus femoris muscle; sartorius muscle; superficial femoral artery; supine position; surgical margin; thigh; tibial tuberosity; va |
Elsevier Ltd |
22102612 |
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Q3 |
232 |
17549 |
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