452 |
Jusuf A.A., Viventius Y., Djaali W. |
57192275719;57223088537;57212479564; |
Comparison between the effectiveness of manual acupuncture and laser acupuncture at ex-b3 weiwanxiashu in a rat model of type 2 diabetes |
2021 |
JAMS Journal of Acupuncture and Meridian Studies |
14 |
2 |
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75 |
81 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107546334&doi=10.51507%2fj.jams.2021.14.2.75&partnerID=40&md5=e5fc6b12ab3bd259eeccdf3c7d1658af |
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Acupuncture, RSUPN Dr. CiptoMangunkusumo, Jakarta, Indonesia; Universitas Negeri Jakarta, Jakarta, Indonesia |
Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Viventius, Y., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Acupuncture, RSUPN Dr. CiptoMangunkusumo, Jakarta, Indonesia; Djaali, W., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Negeri Jakarta, Jakarta, Indonesia |
Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by increased blood sugar levels. The current management of DM to date has a target of controlling blood glucose, but the therapy cannot be separated from long-term drug side effects. Acupuncture can be an option as an adjunct therapy for DM. Objectives: The purpose of this study was to compare the effectiveness between manual acupuncture and laser acupuncture. Methods: This study was a randomized control experimental study with a pretest and posttest design using 24 male Sprague-Dawley rats divided into 4 groups: A normal group, a diabetes group, an acupuncture group, and a laser group. Manual acupuncture and laser acupuncture were performed 6 times in two weeks. Fasting blood glucose (FBG) levels, the cell density of Langerhans islets, and side effects were assessed and compared among the 4 groups. Results: The highest mean cell density of Langerhans islets was found in the laser and acupuncture group, and the lowest was found in the diabetes group. In the post hoc analysis, the normal, acupuncture, and the laser groups had a significantly higher mean cell density than the diabetes group. The lowest mean FBG level was in the laser group, followed by the acupuncture group, and the highest was in the diabetes group, but this difference was not significant. There were no serious side effects from the use of manual acupuncture or laser acupuncture. Conclusion: Both manual acupuncture and laser acupuncture can improve the histological findings of Langerhans islets in type 2 diabetic rats, and both are safe to use. © 2021 Korean Pharmacopuncture Institute. All rights reserved. |
EX-B3; Laser acupuncture; Manual acupuncture; Type 2 diabetes |
glucose; acupuncture; acupuncture point; animal experiment; animal model; Article; cell density; comparative effectiveness; controlled study; erythema; fasting; glucose blood level; laser therapy; male; meichong acupoint; non insulin dependent diabetes mellitus; nonhuman; pancreas islet; post hoc analysis; rat; streptozotocin-induced diabetes mellitus |
Medical Association of pharmacopuncture Institute |
20052901 |
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Article |
Q2 |
374 |
12741 |
|
|
816 |
Pratomo I.P., Ariane A., Tedjo A., Heryanto R., Paramita R.I. |
57192904477;57210643323;57189320451;23392757600;54882436900; |
Xanthine oxidase inhibition in sars-cov-2 infection: The mechanism and potency of allopurinol and febuxostat in covid-19 management |
2021 |
Medical Journal of Indonesia |
30 |
1 |
|
75 |
80 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104949199&doi=10.13181%2fmji.rev.204641&partnerID=40&md5=689e842e1dfa9cde24da9c6f8f7bbee1 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia; Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariane, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Tedjo, A., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia, Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19. © 2020 Authors. |
COVID-19; Free radicals; Uric acid; Xanthine oxidase |
allopurinol; C reactive protein; febuxostat; free radical; gamma interferon; interleukin 2; interleukin 6; reactive oxygen metabolite; uric acid; xanthine oxidase; animal model; coronavirus disease 2019; cytokine production; cytokine storm; drug potency; epithelium; influenza; mouse; neutrophil; nonhuman; oxidative stress; pathogenesis; poultry; respiratory virus; Review; Severe acute respiratory syndrome coronavirus 2; virus infection |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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