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Lee C.-C., Kwa A.L.H., Apisarnthanarak A., Feng J.-Y., Gluck E.H., Ito A., Karuniawati A., Periyasamy P., Pratumvinit B., Sharma J., Solante R., Swaminathan S., Tyagi N., Vu D.M., Zirpe K., Schuetz P. |
57216571107;57277379200;6603905554;24168534700;7003341685;37007598100;54886816200;57218573063;35722893000;12545686500;8728553100;56354453600;56471440500;57214066572;56521747700;35235208800; |
Erratum: Procalcitonin (PCT)guided antibiotic stewardship in Asia-Pacific countries: Adaptation based on an expert consensus meeting. (Clin Chem Lab Med (2020) 58:12 (1983–91) Doi:10.1515/cclm-2019-1122) |
2021 |
Clinical Chemistry and Laboratory Medicine |
59 |
3 |
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632 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100458517&doi=10.1515%2fcclm-2020-1724&partnerID=40&md5=b517d7656483da02741274bbd916bf57 |
Singapore General Hospital, Singapore, Singapore; Emerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore; Division of Infectious Diseases, Thammasart University Hospital, Bangkok, Thailand; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Critical Care Services, Swedish Covenant Hospital, Chicago, IL, United States; Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Department of Microbiology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Infectious Disease Unit, PPUKM (HCTM), Hospital Canselor Tuanku Muhriz UKM (HCTM), Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia; Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Artemis Hospital Critical Care Medicine, Gurgaon, India; Adult Infectious Diseases and Tropical Medicine, San Lazaro Hospital, Manila, Philippines; Infectious Diseases, Gleneagles Global Hospitals, Chennai and Bengaluru, India; Institute of Critical Care and Emergency Medicine, Sir Ganga Ram Hospital, Delhi, India; Critical Care Department, National Hospital of Tropical Diseases, Hanoi, Viet Nam; Department of Neuro Critical Care, Ruby Hall Clinic, Grant Medical Foundation, Pune, India; Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland; University of Basel, Basel, Switzerland |
Lee, C.-C., Singapore General Hospital, Singapore, Singapore; Kwa, A.L.H., Emerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore, Division of Infectious Diseases, Thammasart University Hospital, Bangkok, Thailand; Apisarnthanarak, A., Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Feng, J.-Y., Critical Care Services, Swedish Covenant Hospital, Chicago, IL, United States; Gluck, E.H., Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Ito, A., Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Karuniawati, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Periyasamy, P., Infectious Disease Unit, PPUKM (HCTM), Hospital Canselor Tuanku Muhriz UKM (HCTM), Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia; Pratumvinit, B., Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Sharma, J., Artemis Hospital Critical Care Medicine, Gurgaon, India; Solante, R., Adult Infectious Diseases and Tropical Medicine, San Lazaro Hospital, Manila, Philippines; Swaminathan, S., Infectious Diseases, Gleneagles Global Hospitals, Chennai and Bengaluru, India; Tyagi, N., Institute of Critical Care and Emergency Medicine, Sir Ganga Ram Hospital, Delhi, India; Vu, D.M., Critical Care Department, National Hospital of Tropical Diseases, Hanoi, Viet Nam; Zirpe, K., Department of Neuro Critical Care, Ruby Hall Clinic, Grant Medical Foundation, Pune, India; Schuetz, P., Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland, University of Basel, Basel, Switzerland |
There is typo in Figure 1 and Figure 2 of this article. Instead of “… repeated testing or monitoring for discontinuation …” it should read “… repeated testing for monitoring and discontinuation …” (see corrected Figures). © 2021 De Gruyter. All rights reserved. |
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De Gruyter Open Ltd |
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33554531 |
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626 |
Rachman A., Shatri H., Salamat R. |
15056701600;28767986500;57475263300; |
Correlation Between Higher Cumulative Dose of Cisplatin for Concurrent Chemoradiation and Acute Kidney Disease Incidence Among Nasopharyngeal Carcinoma Patients: A Comparative Study |
2021 |
International Journal of General Medicine |
14 |
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10527 |
10539 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125417489&doi=10.2147%2fIJGM.S343644&partnerID=40&md5=5d12476bf92d703d5d6a77517d01d345 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Psychosomatic and Palliative Care, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Shatri, H., Division of Psychosomatic and Palliative Care, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Salamat, R., Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Nasopharyngeal carcinoma (NPC) is the most malignant cancer in the head and neck area. According to the stage, the management of NPC includes radiation, chemotherapy, or a combination of both. The standard agent for radiosensitizing chemotherapy is cisplatin. Among the several effects of cisplatin administration, nephrotoxicity raises the most concern, especially in high doses. Acute kidney disease (AKD) is a condition in which an acute kidney injury occurs at >7 days but <90 days. This study aimed to assess whether there is a significant difference in the incidence of AKD between NPC patients who received a cumulative dose of cisplatin up to (≤) 200 mg/m2 and patients who received more than (>) 200 mg/m2. Methods: This is a cohort retrospective study conducted in the radiotherapy unit of Cipto Mangunkusumo General Hospital. Medical records of 540 patients from January 2014 to December 2018 were collected and sorted. After sorting, 120 of the records were analyzed. Results: The analysis showed that 38.4% of patients who received >200 mg/m2 cumulative dose of cisplatin experienced AKD, whereas 38.3% of the patients who received ≤200 mg/m2 cumulative dose of cisplatin experienced AKD. Conclusion: This study found that in patients with locally advanced NPC who received cisplatin chemoradiation, there was no significant difference in the incidence of AKD, recovery of renal function, or progression of chronic kidney disease between patients receiving a cumulative dose of cisplatin ≤200 mg/m2 and those receiving >200 mg/m2 . © 2021 Rachman et al. |
Acute kidney disease; Chemoradiation; Cisplatin; Nasopharyngeal cancer |
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Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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635 |
Rahayu G.R., Findyartini A., Riskiyana R., Thadeus M.S., Meidianawaty V., Sari S.M., Puspadewi N., Bekti R.S., Hermasari B.K., Sudarso S., Utami A.E., Kusumawati W. |
56357905400;56543777300;57201674808;57226238484;57205473406;57428214600;57215214003;57195687179;57211539313;57195505857;57427895500;57160948400; |
Stakeholders’ Views and Confidence Towards Indonesian Medical Doctor National Competency Examination: A Qualitative Study |
2021 |
Journal of Multidisciplinary Healthcare |
14 |
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3411 |
3420 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123507676&doi=10.2147%2fJMDH.S336965&partnerID=40&md5=95b31f286039f9e750174fa41df7c1f1 |
Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Faculty of Medicine, Universitas Mulawarman, Samarinda, Indonesia; Ministry of Research, Technology, and Higher Education, Jakarta, Indonesia; Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia |
Rahayu, G.R., Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Findyartini, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Riskiyana, R., Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Thadeus, M.S., Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Meidianawaty, V., Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Sari, S.M., Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia; Puspadewi, N., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Bekti, R.S., Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Hermasari, B.K., Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Sudarso, S., Faculty of Medicine, Universitas Mulawarman, Samarinda, Indonesia; Utami, A.E., Ministry of Research, Technology, and Higher Education, Jakarta, Indonesia; Kusumawati, W., Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia |
Introduction: Indonesia is a huge country consisting of 33 provinces with different characteristics. There are 83 medical schools across Indonesia with different accreditation statuses. The Indonesia Medical Doctor National Competency Examination (IMDNCE) has been established to control the quality of medical school graduates. The implementation of IMDNCE needed to be evaluated to determine its impact. To date, there has not been any research in Indonesia that explores the stakeholders’ perceptions toward IMDNCE. This study aimed to explore how the stakeholders in Indonesia perceived the impact of IMDNCE towards performances of medical school graduates in clinical practice. Methods and Study Participants: A qualitative study with phenomenological approach was conducted to investigate perceptions of stakeholders including representatives from consumer organizations, the National Health Coverage, the Ministry of Health, the Indonesian Medical Association, employers (hospital and health center directors), clinical supervisors as well as patients across Indonesia. Data were obtained through focus group discussions (FGDs) and interviews. The study used thematic analysis methods to obtain the results. Results: A total of 90 study participants participated in the study including 10 representatives of consumer watchdog organizations, the National Health Coverage, the Ministry of Health, the Indonesian Medical Association, 31 employers, 32 professionals, and 17 patients. The study found three general themes which represent the perceptions of the stakeholders towards performances of medical school graduates in clinical practice: IMDNCE as an effort to standardize doctor graduates in Indonesia, the results of IMDNCE as a mean to reflect the quality of medical education in Indonesia, and IMDNCE as an effort to improve health services in Indonesia through the quality of graduates. Conclusion: In general, the stakeholders perceived that the IMDNCE was able to standardize medical school graduates from various medical schools across Indonesia. However, the IMDNCE needs to be further developed to maximize its potential in improving the competences of Indonesian medical students. © 2021 Rahayu et al. |
Medical education; Medical school graduates; National competency examination; Stakeholder view |
adult; article; clinical practice; consumer organization; employer; female; guard dog; health center; human; Indonesia; interview; major clinical study; male; medical education; medical school; medical society; medical student; nonhuman; perception; physician; public health; qualitative research; thematic analysis |
Dove Medical Press Ltd |
11782390 |
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Article |
Q1 |
650 |
7731 |
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653 |
Atmakusuma T.D., Saragih E.Y.P., Rajabto W. |
57216961785;57366253000;36519576100; |
Achievement of pre-and post-transfusion hemoglobin levels in adult transfusion-dependent beta thalassemia: Associated factors and relationship to reduction of spleen enlargement |
2021 |
International Journal of General Medicine |
14 |
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7515 |
7521 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120785623&doi=10.2147%2fIJGM.S338114&partnerID=40&md5=2c1002de475a8646609051daf96840ae |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Tangerang Regional Public Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saragih, E.Y.P., Division of Hematology-Medical Oncology, Department of Internal Medicine, Tangerang Regional Public Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rajabto, W., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: The achievement of blood transfusion hemoglobin targets in transfusiondependent beta-thalassemia patients is influenced by several factors such as genotype, hypersplenism, blood compatibility, donor blood adequacy, and transfusion interval. Failure to achieve these targets leads to an increase in the size of the spleen. Meanwhile, the post-transfusion hemoglobin of thalassemia patients that is not regularly evaluated has made it difficult to determine donor adequacy. Therefore, this study aims to determine the proportion of patients who achieve optimal pre-and post-transfusion hemoglobin levels, determine the factors involved, and the relationship between achieving hemoglobin levels with spleen enlargement in adult transfusion-dependent betathalassemia patients. Methods: This retrospective cohort study was conducted using total sampling of adult thalassemia transfusion-dependent patients at Cipto Mangunkusumo Hospital. Data were obtained through medical records. Results: A hundred and ten study subjects fulfilled inclusion criteria. The results showed that the blood transfusion deficit <30 mL/kg/year was associated with achieving pre-and post-transfusion hemoglobin targets (p = 0.008). Furthermore, there were significant differences between the groups that achieved the pre-and post-transfusion target hemoglobin levels on the reduction of spleen enlargement in centimeters (p < 0.001). However, thalassemia genotype, blood compatibility, and transfusion interval did not correlate with the achievement of pre-and post-transfusion hemoglobin. Conclusion: The achievement of pre-and post-transfusion hemoglobin levels in adult transfusion-dependent beta-thalassemia patients significantly reduced spleen enlargement and contributed to better patient outcomes. © 2021 Atmakusuma et al. This work is published and licensed by Dove Medical Press Limited. |
Risk factors; Spleen enlargement; Target hemoglobin level; Transfusion-dependent beta-thalassemia |
hemoglobin; adult; Article; beta thalassemia; blood compatibility; blood transfusion; cohort analysis; correlation analysis; educational status; employment status; female; genotype; hemoglobin blood level; human; hypersplenism; Indonesia; leukopenia; major clinical study; male; medical record review; retrospective study; spleen size; splenomegaly; thrombocytopenia; treatment outcome; young adult |
Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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654 |
Librianto D., Dilogo I.H., Kamal A.F., Saleh I., Ipang F., Aprilya D. |
57192894799;56161962800;56648996700;57191511801;57226749417;57193710642; |
Effectiveness of kyphosis reduction using cantilever method in thoracolumbar spondylitis tuberculosis: A short-term follow-up |
2021 |
Orthopedic Research and Reviews |
13 |
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275 |
280 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120573379&doi=10.2147%2fORR.S342365&partnerID=40&md5=36fe8c2722165f6ab5ec3cc315858d37 |
Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Librianto, D., Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kamal, A.F., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saleh, I., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ipang, F., Orthopedic Spine Surgeon, Fatmawati General Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Kyphosis in spondylitis tuberculosis (STb) is more than just a cosmetic issue. It has a potentially detrimental effect on both spine-associated structures and cardiopulmonary function. It can be corrected in any stage of STb; however, the corrective surgery is challenging, especially in the late case, in which the additional stiffness of the spine can come into consideration. To date, the cantilever technique is still a gold standard for sagittal plane deformity correction. However, no study to date has explored its effectiveness for thoracolumbar kyphotic deformity, especially that caused by spondylitis tuberculosis. Methods: This is a retrospective study of 16 consecutive cases of spondylitis tuberculosis with thoracolumbar kyphosis that underwent corrective surgery in our center in the period of 2020–2021. We aim to evaluate the effectiveness of the cantilever technique that we use for kyphotic correction in thoracolumbar STb patients. Results: At the 3-months follow-up, the mean Cobb angle was 14.6°±10.27°, with the mean gain of 20.90°±12.00° and positively correlate with the thoracolumbar kyphosis (TLK) correction (68.69%, r = 0.654, p = 0.001). The mean thoracic kyphosis, lumbar lordosis, and sagittal vertebral axis were 30.6°±13.08°, 39.4°±16.02°, and 1.4±4.09 cm, respectively, with sagittal Cobb difference of 12.70±9.85. Conclusion: The kyphotic Cobb angle reduction by cantilever technique in the thoracolumbar area significantly improved the thoracolumbar kyphosis and realign the spinal sagittal axis. Thus, the cantilever technique remains the gold standard for sagittal plane deformity correction which can be applied for kyphotic deformity correction in thoracolumbar STb cases. © 2021 Librianto et al. |
Cantilever technique; Deformity correction; Kyphotic deformity; Spondylitis tuberculosis; Thoracolumbar spine |
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Dove Medical Press Ltd |
11791462 |
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Article |
Q2 |
707 |
7037 |
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658 |
Gatam A.R., Gatam L., Mahadhipta H., Ajiantoro A., Luthfi O., Aprilya D. |
57189987623;57197708604;57210642162;57357077400;57356571700;57193710642; |
Unilateral biportal endoscopic lumbar interbody fusion: A technical note and an outcome comparison with the conventional minimally invasive fusion |
2021 |
Orthopedic Research and Reviews |
13 |
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229 |
239 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120168036&doi=10.2147%2fORR.S336479&partnerID=40&md5=975bbbda77330a970b9d9c16d7f501be |
Orthopaedic Spine Division, Fatmawati General Hospital, Jakarta, Indonesia; Orthopaedic Spine Division, Tangerang General Hospital, Banten, Indonesia; Orthopaedic Spine Division, Premier Bintaro Hospital, Banten, Indonesia; Orthopedic Spine Division, Adhyaksa General Hospital, Jakarta, Indonesia; Orthopedic and Traumatology Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Gatam, A.R., Orthopaedic Spine Division, Fatmawati General Hospital, Jakarta, Indonesia; Gatam, L., Orthopaedic Spine Division, Fatmawati General Hospital, Jakarta, Indonesia; Mahadhipta, H., Orthopaedic Spine Division, Tangerang General Hospital, Banten, Indonesia; Ajiantoro, A., Orthopaedic Spine Division, Premier Bintaro Hospital, Banten, Indonesia; Luthfi, O., Orthopedic Spine Division, Adhyaksa General Hospital, Jakarta, Indonesia; Aprilya, D., Orthopedic and Traumatology Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: In the past few decades, the minimally invasive technique for spine surgery has developed extensively from the scope of decompression until fusion surgeries to reduce damages to the normal anatomical structure. Unilateral biportal endoscopic lumbar interbody fusion (ULIF) is one of the fusion options which is readily available without a sophisticated minimal invasive instrument. Our aim is to introduce ULIF experience in our center and comparing the result with conventional minimally invasive lumbar interbody fusion (MIS-TLIF). Methods: This is a retrospective cohort study of 145 lumbar spondylolisthesis cases that underwent fusion surgery with either ULIF or the conventional MIS-TLIF. All of the patients were observed within a 12-month follow-up period to evaluate the back pain and leg pain Visual Analogue Score (VAS), the Oswestry Disability Index (ODI), the 36-Item Short Form Health Survey (SF-36), and fusion rate. Results: The leg pain VAS was similarly improved in both groups. ULIF has a significant back pain improvement on direct post operation and at the 3-months follow-up (p value 0.032 and 0.046 respectively). ULIF group also had a significantly better improvement of ODI scores on the early post-operative period (p=0.045). However, both groups similarly showed improvement of ODI score and the SF-36 at the 3-, 6-, and 12-months follow up. Conclusion: Full endoscopic fusion surgery with ULIF offers a comparable long-term outcome and a significantly better back pain VAS reduction in short-term follow up compared to the conventional MIS-TLIF. ULIF, with further improvement, can be the next gold standard in managing degenerative lumbar spine conditions. © 2021 Gatam et al. |
Degenerative spondylolisthesis; Full endoscopic spine surgery; Lumbar interbody fusion; Lumbar spine; Minimally invasive spine surgery; MISS; Unilateral biportal endoscopy |
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Dove Medical Press Ltd |
11791462 |
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Article |
Q2 |
707 |
7037 |
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665 |
Atmakusuma T.D., Nasution I.R., Sutandyo N. |
57216961785;8259214700;26028099200; |
Oxidative stress (Malondialdehyde) in adults beta-thalassemia major and intermedia: Comparison between before and after blood transfusion and its correlation with iron overload |
2021 |
International Journal of General Medicine |
14 |
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6455 |
6462 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119614825&doi=10.2147%2fIJGM.S336805&partnerID=40&md5=31da8ca15b655debd14557088a36df4a |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Gatot Soebroto Army Hospital Jakarta/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital Jakarta/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nasution, I.R., Division of Hematology-Medical Oncology, Department of Internal Medicine, Gatot Soebroto Army Hospital Jakarta/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sutandyo, N., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital Jakarta/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Iron overload is a major problem in both transfusion-dependent (TDT) and non-transfusion-dependent thalassemia (NTDT). It has been known to increase oxidative stress. Meanwhile, blood transfusion as main therapy for thalassemia increases iron overload. One of the markers of oxidative stress is malondialdehyde (MDA). This study aims to provide data on MDA levels in adult thalassemia patients, and to compare the levels before and after transfusion in patients with TDT and NTDT. Methods: This is a cross-sectional, pre-post study in adult patients with thalassemia major and intermedia that received blood transfusion with or without iron-chelating agents in Cipto Mangunkusumo Hospital. Blood samples were taken immediately before the transfusion and one day after. Serum ferritin (SF) assays were conducted by electrochemiluminescence immunoassay method, while transferrin saturation (TS) was calculated by dividing serum iron by the binding capacity. Subsequently, plasma MDA levels assays were performed using the Wills method, and data analysis was conducted using the t-test/Mann–Whitney and Pearson/Spearman correlation test, depending on the data distribution. Results: The 63 respondents recruited consist of 51 TDT and 12 NTDT patients, and their median plasma MDA level before and after transfusion was 0.49 µmol/L and 0.45 µmol/L, respectively. Before transfusion, there was no correlation between SF and MDA, and TS and MDA levels. After the transfusion, there was no correlation between, SF and MDA, or TS and MDA levels. Conclusion: There is no significant difference in MDA levels before and after transfusion. Although blood transfusion increases the iron load in thalassemia patients, there was no increase in median MDA level after transfusion. Meanwhile, there was no correlation between markers of iron overload and MDA level in thalassemia patients both before and after transfusion. © 2021 Atmakusuma et al. This work is published and licensed by Dove Medical Press Limited. |
Iron overload; Malondialdehyde; Non-transfusion dependent thalassemia; Oxidative stress; Transfusion-dependent thalassemia |
deferasirox; deferiprone; deferoxamine; ferritin; malonaldehyde; adult; aged; Article; blood transfusion; controlled study; cross-sectional study; female; ferritin blood level; hemoglobin E-beta thalassemia; human; Indonesia; iron chelation; iron overload; major clinical study; male; non transfusion dependent thalassemia; oxidative stress; thalassemia major; transferrin saturation; transfusion dependent thalassemia |
Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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673 |
Kaaffah S., Soewondo P., Riyadina W., Renaldi F.S., Sauriasari R. |
57331465300;23475336100;57208470391;57331465400;16246507200; |
Adherence to treatment and glycemic control in patients with type 2 diabetes mellitus: A 4-year follow-up ptm bogor cohort study, indonesia |
2021 |
Patient Preference and Adherence |
15 |
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2467 |
2477 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118951660&doi=10.2147%2fPPA.S318790&partnerID=40&md5=079f3b92c2c91638e7785757da719eff |
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr.Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; National Institute of Health Research and Development, Ministry of Health Republic of Indonesia, Jakarta, Indonesia |
Kaaffah, S., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Soewondo, P., Division of Endocrinology, Department of Internal Medicine, Dr.Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Riyadina, W., National Institute of Health Research and Development, Ministry of Health Republic of Indonesia, Jakarta, Indonesia; Renaldi, F.S., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia |
Purpose: Large-scale evaluation of the treatment adherence in patients with type 2 diabetes mellitus (DM) in Indonesian is limited. We aim to evaluate the treatment adherence of Indonesian type 2 DM patients using national “big data” and investigate its association with glycemic parameters. Patients and Methods: We analyzed baseline and fourth-year data sets from 2011 to 2018 obtained from the Indonesian Ministry of Health Cohort Study of Non-Communicable Disease Risk Factors in Bogor, West Java (the PTM Bogor Cohort Study). This was a retrospective cohort study in which the sample was divided into two groups. One group adhered to treatment from primary health centers and followed the prescribed medicine/ treatment regimen (treated group), while the other did not follow the treatment (untreated group). We evaluated changes in fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) by controlling for other variables. Results: From 5690 subjects, 593 were type 2 DM diagnosed and 342 were eligible at the baseline. At 4-year observation, 212 eligible patients remained, consisting of 62 subjects who adhered to treatment, and more than double that number who were untreated (150 subjects). More significant decreases in FBG and PPBG were found in the treated group (FBG 80.6%, PPBG 90.3%) than in the untreated group (FBG 42.0%, PPBG 67.3%). The results of the multivariate analysis showed that after 4 years observation, treated patients have reduced FBG 3.304 times more and PPBG 3.064 times more than untreated patients, with control factors such as decrease in LDL levels and use of oral drugs. Conclusion: There were less than half as many treated patients as untreated patients involved in the PTM Bogor Study Group. At the fourth-year follow-up, treated patients experienced three times more significant decreases in FBG and PPBG than those who were untreated, even after being controlled by several confounding factors. Given the importance of these findings, it is suggested that immediate strategic action be taken to improve Indonesian patients’ adherence to treatment. © 2021 Kaaffah et al. |
Cohort; Diabetes mellitus; Fasting blood glucose; Post-prandial blood glucose; Treatment adherence |
glibenclamide; glimepiride; glucose; insulin; low density lipoprotein; metformin; sulfonylurea; adult; Article; big data; cohort analysis; controlled study; fasting; female; follow up; glucose blood level; glycemic control; human; Indonesia; major clinical study; male; medication compliance; middle aged; non insulin dependent diabetes mellitus; patient compliance; prescription; primary health care; retrospective study |
Dove Medical Press Ltd |
1177889X |
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885 |
5263 |
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677 |
Vandenplas Y., Brough H.A., Fiocchi A., Miqdady M., Munasir Z., Salvatore S., Thapar N., Venter C., Vieira M.C., Meyer R. |
57223670656;37064383600;7006595735;26664817800;7801694370;55390678300;8337607800;35944268900;8270521000;7404078956; |
Current guidelines and future strategies for the management of cow’s milk allergy |
2021 |
Journal of Asthma and Allergy |
14 |
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1244 |
1256 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118723222&doi=10.2147%2fJAA.S276992&partnerID=40&md5=2b3b3cbc9500f0760551157f099bf4c4 |
Vrije Universiteit Brussel (VUB), UZ Brussel, KidZ Health Castle, Brussels, Belgium; Department Women and Children’s Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom; Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St, Thomas’s NHS Foundation Trust, London, United Kingdom; Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children’s Hospital, IRCCS, Piazza Sant’Onofrio, Rome, Italy; Department of Pediatrics, Sheikh Khalifa Medical City, College of Medicine & Health Sciences, Khalifa University, Khalifa, United Arab Emirates; Department of Child Health, Ciptomangunkusumo Hospital-Medical Faculty Universitas Indonesia, Jakarta, Indonesia; Pediatric Department, Hospital “F. Del Ponte”, University of Insubria, Varese, Italy; Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital, Brisbane, QLD, Australia; University of Colorado, Children’s Hospital Colorado, Denver, CO, United States; Center for Pediatric Gastroenterology-Hospital Pequeno Príncipe, Curitiba, Brazil; Department of Paediatrics, Imperial College, London, United Kingdom; Department Nutrition and Dietetics, University of Winchester, Winchester, United Kingdom |
Vandenplas, Y., Vrije Universiteit Brussel (VUB), UZ Brussel, KidZ Health Castle, Brussels, Belgium; Brough, H.A., Department Women and Children’s Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom, Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St, Thomas’s NHS Foundation Trust, London, United Kingdom; Fiocchi, A., Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children’s Hospital, IRCCS, Piazza Sant’Onofrio, Rome, Italy; Miqdady, M., Department of Pediatrics, Sheikh Khalifa Medical City, College of Medicine & Health Sciences, Khalifa University, Khalifa, United Arab Emirates; Munasir, Z., Department of Child Health, Ciptomangunkusumo Hospital-Medical Faculty Universitas Indonesia, Jakarta, Indonesia; Salvatore, S., Pediatric Department, Hospital “F. Del Ponte”, University of Insubria, Varese, Italy; Thapar, N., Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital, Brisbane, QLD, Australia; Venter, C., University of Colorado, Children’s Hospital Colorado, Denver, CO, United States; Vieira, M.C., Center for Pediatric Gastroenterology-Hospital Pequeno Príncipe, Curitiba, Brazil; Meyer, R., Department of Paediatrics, Imperial College, London, United Kingdom, Department Nutrition and Dietetics, University of Winchester, Winchester, United Kingdom |
Exclusive breast feeding is recommended in all guidelines as the first choice feeding. Cow milk allergy (CMA) can be diagnosed by a diagnostic elimination diet for 2 to 4 weeks with a hypo-allergenic formula, followed by a challenge test with intact cow milk protein. The most often used hypo-allergenic formula for the diagnostic elimination diet and the therapeutic diet is a CM based extensive hydrolysate. CM-based partial hydrolysates cannot be recommended in the management of CMA because of insufficient efficacy and possible reactions, but about half of the infants with CMA may tolerate a partial hydrolysate. The pros and cons of other dietary options are discussed in this paper. The use of an amino acid-based formula and/or rice based hydrolysate formula during the diagnostic elimination and therapeutic diet is debated. When available, there is sufficient evidence to consider rice hydrolysates as an adequate alternative to CM-based hydrolysates, since some infants will still react to the CM hydrolysate. The pros and cons of dietary options such as soy formula, buckwheat, almond, pea or other plant based dietary products are discussed. Although the majority of the plant-based beverages are nutritionally inadequate, some are nutritionally adapted for toddlers. However, accessibility and content vary by country and, thus far there is insufficient evidence on the efficacy and tolerance of these plant-based drinks (except for soy formula and rice hydrolysates) to provide an opinion on them. Conclusion: A diagnostic elimination diet, followed by a challenge remains the diagnostic standard. The use of an awareness tool may result in a decrease of delayed diagnosis. Breastmilk remains the ideal source of nutrition and when not available a CM extensively hydrolyzed formula, rice hydrolysate or amino acid formula should be recommended. More evidence is needed regarding plant-based drinks. © 2021 Vandenplas et al. |
Amino acid formula; Challenge test; Cow milk allergy; Hydrolysate; Plant-based drink; Rice hydrolysate; Soy formula |
alpha 1 antitrypsin; amino acid based formula; beta defensin; beta lactoglobulin; calcium; calgranulin; casein hydrolysate; cyanocobalamin; folic acid; food allergen; immunoglobulin A; immunoglobulin E; immunoglobulin G4; iodine; partial hydrolysate formula; prebiotic agent; probiotic agent; short chain fatty acid; soybean protein; tumor necrosis factor; unclassified drug; vitamin; allergenicity; almond; asthma; awareness; beverage; Bifidobacteriaceae; breast feeding; buckwheat; buffalo milk; camel milk; child growth; Clinical awareness score; colic; cow milk; Cow’s Milk related Symptom Score; dietary compliance; dietary fiber; donkey milk; double blind procedure; eczema; elimination diet; eosinophilic esophagitis; evidence based practice; facial angioedema; food intake; futurology; health |
Dove Medical Press Ltd |
11786965 |
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Review |
Q1 |
1162 |
3475 |
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684 |
Sukrisman L., Sinto R., Priantono D. |
8661764000;36099377100;57219443427; |
Hematologic profiles and correlation between absolute lymphocyte count and neutrophil/ lymphocyte ratio with markers of inflammation of covid-19 in an indonesian national referral hospital |
2021 |
International Journal of General Medicine |
14 |
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6919 |
6924 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117751905&doi=10.2147%2fIJGM.S337440&partnerID=40&md5=3dd70fba2ee4c7395a09b7807a9e5c42 |
Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Sukrisman, L., Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sinto, R., Division of Tropical and Infectious Disease, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Priantono, D., Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: COVID-19 is a pandemic with significant mortality and it is important to differentiate severe and non-severe cases. We conducted a study to evaluate hematologic profiles with inflammation markers in COVID-19 patients and to determine the correlation of neutrophil-lymphocyte ratio (NLR) with disease severity. Methods: A cross-sectional study involving hospitalized COVID-19 patients confirmed with a positive SARS-CoV-2 PCR test in Dr. Cipto Mangunkusumo Hospital. Lymphocyte count, NLR, C-reactive protein (CRP) and ferritin were evaluated in severe and non-severe COVID-19 cases at hospital admission. Data was analyzed using Spearman correlation. Results: There were 41 patients aged 20 to 79 years with COVID-19; 33 (80.5%) were nonsevere, and 8 (19.5%) were severe cases. There is a statistically significant difference in WBC, relative neutrophils and lymphocytes, NLR, and CRP between non-severe and severe cases. There is a strong correlation between NLR and CRP (r = 0.738; p < 0.001). Our findings show that NLR and absolute lymphocyte count, but not ferritin, play a role in differentiating between non-severe and severe COVID-19 cases. Conclusion: In COVID-19 cases, a strong correlation between NLR and CRP might suggest the use of NLR to differentiate between non-severe and severe cases, especially in a remote healthcare facility. © 2021 Sukrisman et al. This work is published and licensed by Dove Medical Press Limited. |
COVID-19; Hematologic profiles; Inflammation; Lymphocyte; NLR |
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Dove Medical Press Ltd |
11787074 |
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