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685 |
Lubis A.M.T., Reksoprodjo A.Y., Kuncoro M.W., Ifran N.N. |
15122639800;57208385626;57214136871;56091403800; |
Post-acl reconstruction graft failure in severe gout arthritis patient |
2021 |
International Medical Case Reports Journal |
14 |
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725 |
730 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117588489&doi=10.2147%2fIMCRJ.S325642&partnerID=40&md5=7d6c96304b0f081df9890285db073149 |
Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lubis, A.M.T., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Reksoprodjo, A.Y., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kuncoro, M.W., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ifran, N.N., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Pain and instability following an anterior cruciate ligament (ACL) reconstruction remain a significant issue. Common causes include infection and inflammation, and mechanical issues such as graft failure. Case Presentation: A 36-year-old male with an ACL reconstruction six years prior was admitted due to pain and swelling. The ACL graft that had ruptured was found arthrosco-pically. Numerous gout crystals and tophus were observed inside. This finding is suggested as a cause of this kind of complication. Discussion: Biological failure is one of the causes of graft failure. Gout arthritis is associated with internal derangement of the joint structures, which is reported in advanced case. Conclusion: Severe gouty arthritis, even though rare, could be an etiology of graft failure following ACL reconstruction and cause significant morbidity. © 2021 Lubis et al. |
ACL reconstruction; Gout; Graft failure; Tophus |
urate; adult; anterior cruciate ligament reconstruction; arthroscopic debridement; Article; case report; clinical article; gout; graft failure; hamstring graft; human; human tissue; hyperuricemia; joint effusion; joint limitation; joint stiffness; joint swelling; knee arthroscopy; knee instability; knee pain; knee radiography; male; muscle graft |
Dove Medical Press Ltd |
1179142X |
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Article |
Q4 |
198 |
19482 |
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705 |
Muharam R., Sumapraja K., Pratama G., Azyati M., Prabowo K.A. |
57191492732;55819683500;57195959221;57274785700;57224859187; |
Impact of ivf on the timing and symptoms of menopause |
2021 |
International Journal of Women's Health |
13 |
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889 |
893 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115838581&doi=10.2147%2fIJWH.S322718&partnerID=40&md5=6d1216144e47b8cdba986eef18fc94e5 |
Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Muharam, R., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Sumapraja, K., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Pratama, G., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Azyati, M., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Prabowo, K.A., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Background: Age-related loss of female fertility is characterized by a decline in both the quantity and quality of ovarian follicles. Symptoms of ovarian stimulation, which is part of the process of in vitro fertilization (IVF), vary among women. This study was conducted to analyze the differences in menopausal timing and symptoms in women who had undergone IVF compared to those who had natural pregnancies. Methodology: In this cross-sectional study, menopausal women were categorized into two groups: those who had undergone IVF (n = 50) and those who had not (n = 50). Clinical data were obtained from the participants’ medical records, and patient interviews were conducted using the menopause rating scale (MRS) questionnaires. Results: The IVF had no significant impact on psychological or somatic symptoms in either group (p>0.05). However, it affected urogenital symptoms (p<0.05). Additionally, there was a significant difference in the age of onset of menopause between the groups (p<0.05). Conclusion: There is a significant correlation between IVF treatment, urogenital symptoms in menopause, and the age of onset of menopause. © 2021 Muharam et al. This work is published and licensed by Dove Medical Press Limited. |
In vitro fertilization; Infertility; Menopause; Psychological symptoms; Urogenital |
adult; anxiety; arthralgia; Article; bladder dysfunction; clinical article; cross-sectional study; depression; exhaustion; female; hot flush; human; in vitro fertilization; irritability; menopause; menopause rating scale; middle aged; myalgia; onset age; rating scale; risk factor; sexual dysfunction; sleep disorder; vaginal dryness |
Dove Medical Press Ltd |
11791411 |
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Article |
Q1 |
1136 |
3603 |
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706 |
Wardhani B.W.K., Louisa M., Watanabe Y., Setiabudy R., Kato M. |
57194342020;41461551400;56040433300;6602316235;57222489115; |
Tgf-β-induced tmepai promotes epithelial– mesenchymal transition in doxorubicin-treated triple-negative breast cancer cells via smad3 and pi3k/akt pathway alteration |
2021 |
Breast Cancer: Targets and Therapy |
13 |
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529 |
538 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115827526&doi=10.2147%2fBCTT.S325429&partnerID=40&md5=0fe888a00b703b194e1cca6235180684 |
Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Faculty of Military Pharmacy, Indonesia Defense University, West Java, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
Wardhani, B.W.K., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pharmacology, Faculty of Military Pharmacy, Indonesia Defense University, West Java, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Watanabe, Y., Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kato, M., Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
Introduction: Epithelial–mesenchymal transition (EMT) and overexpression of drug efflux transporters have been reported to cause doxorubicin resistance. Our previous study indicated that TMEPAI (transmembrane prostate androgen-induced protein) attenuated doxorubicin sensitivity in triple-negative breast cancer cells. However, how TMEPAI contributes to doxorubicin resistance in TNBC remains unclear. Thus, the present study aimed to elucidate the mechanism of TMEPAI in doxorubicin resistance in triple-negative breast cancer cells. Methods: We used BT549, triple-negative cells wild type (WT), and BT549 TMEPAI knock-out. Both cells were treated with TGF-β 2 ng/mL for 24 hours, followed by TGF-β 2 ng/mL and doxorubicin 12.9 nM for another 24 hours. Afterward, the cells were harvested and counted. Cells were further lysed and used for RT-PCR and Western blot analysis. We determined the expression levels of proliferation, apoptosis, EMT markers, and drug efflux transporters. Additionally, we investigated the expressions of PI3K as well as SMAD3 and AKT phosphorylation. Results: TNBC cells were shown to be less sensitive to doxorubicin in the presence of TMEPAI. TMEPAI was shown to alleviate the mRNA expressions of apoptosis markers: Bax, Bcl2, Caspase-3, and Caspase-9. Our results indicated that the presence of TMEPAI greatly amplifies EMT and increases drug efflux transporter expressions after doxorubicin treatment. Furthermore, our findings demonstrated that TMEPAI reduced the action of doxorubicin in inhibiting SMAD3 phosphorylation. TMEPAI was also shown to modify the effect of doxorubicin by reducing PI3K expressions and Akt phosphorylation in triple-negative breast cancer cells. Conclusion: Our findings indicate that TMEPAI promotes EMT and drug efflux transporters at least in part by shifting doxorubicin action from SMAD3 phosphorylation reduction to PI3K/AKT inhibition in triple-negative breast cancer cells. © 2021 Wardhani et al. |
Drug efflux transporters; E-cadherin; PMEPAI; SMAD3; TGF-β; Vimentin |
ABC transporter subfamily B; caspase 3; caspase 9; complementary DNA; doxorubicin; Ki 67 antigen; membrane protein; protein Bax; Smad3 protein; transforming growth factor beta; transmembrane prostate androgen induced protein; unclassified drug; uvomorulin; vimentin; apoptosis; Article; breast cancer cell line; cell proliferation; cell viability; chemoluminescence; controlled study; CRISPR-CAS9 system; down regulation; epithelial mesenchymal transition; gene expression; gene overexpression; human; human cell; mRNA expression level; Pi3K/Akt signaling; protein expression; protein phosphorylation; real time polymerase chain reaction; RNA extraction; signal transduction; upregulation; Western blotting |
Dove Medical Press Ltd |
11791314 |
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Article |
Q2 |
1190 |
3344 |
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711 |
Atmakusuma T.D., Tenggara J.B. |
57216961785;26028154300; |
Correlation of transferrin saturation and serum ferritin with bone mass density in adult transfusion dependent beta-thalassemia patients |
2021 |
Journal of Blood Medicine |
12 |
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827 |
832 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115292368&doi=10.2147%2fJBM.S328547&partnerID=40&md5=136e30d4eafe0cf460ffe633d41e4fd8 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tenggara, J.B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Hematology-Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Background: The use of regular blood transfusions and iron chelation therapy to treat thalassemia has improved survival and increased the incidence of osteoporosis. Moreover, iron toxicity is one of the contributing factors that reduce bone mass density in adult transfusion-dependent beta-thalassemia patients. Therefore, this study aims to determine the proportion of low bone mass density in adult thalassemia patients and transferrin saturation, as well as serum ferritin, which correlates to the skeletal condition. Methods: This is a cross-sectional study conducted in Thalassemia and Hematology Medical Oncology Clinics of Cipto Mangunkusumo Hospital in March 2016. The anthropo-metric data and hemoglobin levels were obtained before transfusion. Subsequently, the average ferritin levels, bone mineral density, and radiographic results were obtained. Results: The percentage of adult thalassemia major and intermedia patients with low bone mass density was 68%. Also, there was a weak inverse correlation between bone mass density and transferrin saturation (r = −0.329, p = 0.01), while no correlation was shown between bone mass density and ferritin (r = −0.088, p = 0.504). The transferrin saturation cutoff point value used to distinguish the incidence of low and normal bone density in patients with transfusion-dependent beta-thalassemia was 89.5%. In addition, there was weak correlation between Singh index and bone mass density (r = 0.273, p = 0.038). Conclusion: Among the transfusion-dependent beta-thalassemia patients, 68% had low bone mass density, which inversely correlated to transferrin saturation. Furthermore, the cutoff value of transferrin saturation to differentiate the incidence of low and normal bone density in thalassemia major compared to thalassemia intermedia was 89.5%. Singh Index correlates weakly with bone mass density and might be used to detect low bone mass density in remote healthcare facilities. © 2021 Atmakusuma and Tenggara. |
Bone mass density; Ferritin; Thalassemia; Transferrin; Transfusion dependent beta |
C reactive protein; calcium; chloride; magnesium; phosphate; potassium; sodium; adult; aged; anthropometry; Article; beta thalassemia; blood transfusion; bone densitometry; bone density; correlational study; cross-sectional study; dual energy X ray absorptiometry; female; ferritin blood level; hemoglobin blood level; human; major clinical study; male; radiography; receiver operating characteristic; scoring system; sensitivity and specificity; singh index; transferrin saturation |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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715 |
Puspita F.M., Yunir E., Agustina P.S., Sauriasari R. |
57257264000;36520254800;57217065969;16246507200; |
Effect of angiotensin receptor blocker and angiotensin converting enzyme inhibitor on kidney function and blood potassium level in indonesian type 2 diabetes mellitus with hypertension: A three-month cohort study |
2021 |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
14 |
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3841 |
3849 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114809524&doi=10.2147%2fDMSO.S310091&partnerID=40&md5=4d027eb31fcf71d05393ccf9ca3738b6 |
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Puspita, F.M., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Agustina, P.S., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia |
Purpose: National formulary restrictions in Indonesia (2019) require estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m2 to be able to prescribe telmisartan and valsartan and ACE-I intolerance to be able to prescribe irbesartan and candesartan. These restrictions are based on economic considerations and differ from American Diabetes Association (ADA) (2020) guidelines which allow equal use of angiotensin II receptor blockers (ARB) and angiotensin-converting enzyme inhibitors (ACE-I) without restriction. Since there is a need to evaluate the different effects of ACE-I and ARB in the Indonesian hypertensive type 2 diabetes mellitus (T2DM) population, we compare their effects on urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and blood potassium level. Patients and Methods: A prospective cohort study at RSUPN Dr. Cipto Mangunkusumo Hospital was conducted in 123 T2DM patients. We followed the study subjects prospectively for three months using a validated questionnaire, health record, and laboratory data. Results: After 3 months of observation, there were no significant changes, except increased BMI values (p = 0.046) in the ACE-I group, and decreased LDL value (p = 0.016) and HDL value (p = 0.004) in the ARB group. Multivariate analysis showed that the consumption of ACE-I or ARB was not associated with a decrease/constant of UACR or increase potassium level, even after adjusting by confounding variables. Interestingly, we found ARB was more likely to increase eGFR, but the significance was lost once the duration of ACE-I/ARB use was entered into the model. In addition, BMI >25 kg/m2 was a significant factor associated with decreased/constant UACR, maleness was significant for increased eGFR, and declining systolic blood pressure for increase in potassium level. Conclusion: ACE-I and ARB have a similar effect on UACR and blood potassium level, but ARB slightly increased eGFR compared to ACE-I within three months of consumption. © 2021 Puspita et al. |
Angiotensin II receptor blockers; Angiotensin-converting enzyme inhibitors; Chronic kidney disease; EGFR; Type 2 diabetes mellitus; UACR |
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Dove Medical Press Ltd |
11787007 |
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Article |
Q2 |
853 |
5525 |
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724 |
Gunawan H., Kamilia A., Menaldi S.L., Marissa M., Prakoeswa C.R.S., Alinda M.D., Widasmara D., Basuki S., Anum Q., Ariani T., Mamuaja E.H., Rusyati L.M.M. |
55553742589;57201077194;57192918198;57210795916;57189894608;57202009260;57191841830;57221775070;57246220800;57246220900;57246221000;35724714700; |
Characteristics of grade 2 disability in indonesian children with leprosy: A five-year multicenter retrospective study |
2021 |
Clinical, Cosmetic and Investigational Dermatology |
14 |
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1149 |
1153 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114228929&doi=10.2147%2fCCID.S325858&partnerID=40&md5=d2179cc77df886c28de43e2ca3ed6dd3 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia; Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia; Indonesian College of Dermatology and Venereology, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Soetomo Hospital, Surabaya, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sam Ratulangi, Prof. R. D. Kandou Hospital, Manado, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia |
Gunawan, H., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia, Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Indonesian College of Dermatology and Venereology, Jakarta, Indonesia; Kamilia, A., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia, Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia; Menaldi, S.L., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Indonesian College of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marissa, M., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prakoeswa, C.R.S., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Indonesian College of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Soetomo Hospital, Surabaya, Indonesia; Alinda, M.D., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Soetomo Hospital, Surabaya, Indonesia; Widasmara, D., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Basuki, S., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Anum, Q., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Ariani, T., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Mamuaja, E.H., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sam Ratulangi, Prof. R. D. Kandou Hospital, Manado, Indonesia; Rusyati, L.M.M., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia |
Background: One of the indicators of achieved leprosy control is lower new cases of leprosy with grade 2 disability (G2D), while zero new pediatric case with G2D is one of the targets of The Global Leprosy Strategy. This study aimed to describe the characteristics of leprosy in children with G2D from seven provincial hospitals in Indonesia, spanning a period of five years. Methods: This was a descriptive and retrospective study with cross-sectional design. Data were obtained from the medical records of leprosy-affected children in seven provincial hospitals in Indonesia between January 2014 and December 2019 using a total sampling method. Data obtained include characteristics of patients, clinical manifestations, and profile of leprosy in children with G2D. Results: From the 132 data of childhood leprosy retrieved, male (58.33%), age group of 13– 14 years (47.73%), and borderline tuberculoid leprosy (34.09%) comprised the majority of patients. Most of the patients had anesthetic macules as the initial manifestation. The results showed 20 (15.15%) children had G2D. Hands were the most common site affected (50.00%), manifested as claw hands, contractures, atrophy of thenar and hypothenar muscles, and pseudomutilation. Foot drop was seen in five (62.50%) children, and lagophthalmos was seen in one child with leprosy. Conclusion: This study shows that G2D is observed in 15.15% Indonesian children with leprosy at the time of diagnosis, which mostly occurs on the hands in the form of claw hands. Foot disabilities were also observed, most commonly as foot drop, while lagophthalmos was present with disabilities in the eyes. Disability due to leprosy in children really exists. The commitment of all health care services and related institutions is needed in order to reduce the incidence of disability due to leprosy in children. © 2021 Gunawan et al. |
Children; Grade 2 disability; Leprosy |
adolescent; Article; borderline leprosy; child; claw hand; contracture; cross-sectional study; disability; female; grade 2 disability; human; lagophthalmos; leprosy; major clinical study; male; medical record review; muscle atrophy; peroneus nerve paralysis; preschool child; retrospective study; school child; tuberculoid leprosy |
Dove Medical Press Ltd |
11787015 |
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Article |
Q2 |
730 |
6764 |
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730 |
Atmakusuma T.D., Hasibuan F.D., Purnamasari D. |
57216961785;57227028400;36519537700; |
The correlation between iron overload and endocrine function in adult transfusion-dependent beta-thalassemia patients with growth retardation |
2021 |
Journal of Blood Medicine |
12 |
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749 |
753 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113290577&doi=10.2147%2fJBM.S325096&partnerID=40&md5=dd85b4afdd08b0c54b3857a4d69f80f1 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Yarsi Hospital, Jakarta, Indonesia; Endocrine and Metabolic Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hasibuan, F.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Yarsi Hospital, Jakarta, Indonesia; Purnamasari, D., Endocrine and Metabolic Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Iron overload is a major problem in patients with transfusion-dependent beta-thalassemia (TDT). Reports on the correlation between iron overload and endocrine function with growth retardation in such a population in Indonesia have not been established. Therefore, this study aims to obtain a profile of iron load and endocrine function of adult transfusion dependent beta-thalassemia patients and their correlation with growth retardation. Methods: A cross-sectional study was performed, involving adult homozygous and HbE beta-thalassemia patients receiving blood transfusions at the Cipto Mangunkusumo Hospital, Jakarta. Iron overload was represented by serum ferritin (FS) and transferrin saturation (TS), while the endocrine function was examined by the Thyroid Stimulating Hormone-sensitive (TSHs), free T4 (fT4), and insulin-like growth factor-1 (IGF-1). The results were analyzed using bivariate analysis plus Pearson and Spearman correlation tests. Results: In general, 58 subjects were selected from 224 adult transfusion dependent beta-thalassemia patients, consisting of 31 males (53.4%) and 27 females (46.6%). Furthermore, their median age was 21 (18–24) years, while the subclinical hypothyroid proportion was 32.7% and low IGF-1 levels were detected in 79.3% of the total population. There was a weak negative correlation between FS and fT4 (Spearman rho=−0.361; p=0.003), as well as IGF-1 (Spearman rho=−0.313; p=0.008), but FS and TSHs had no correlation (Spearman rho=0.074; p=0.29). Also, there was no correlation between ST with TSHs (Spearman rho=0.003; p=0.492), fT4 (Spearman rho=0.018; p=0.448), and IGF-1 (Spearman rho= −0.142; p=0.143). Conclusion: Based on serum ferritin, iron overload is discovered to have a negative correlation with free T4 and insulin-like growth factor-1. © 2021 Atmakusuma et al. |
FT4; IGF-1; Serum ferritin; Transferrin saturation; Transfusion-dependent thalassemia; TSHs |
ferritin; hemoglobin; somatomedin C; thyroid antibody; thyroid stimulating immunoglobulin; thyrotropin; transferrin; adult; Article; body mass; chemiluminescence immunoassay; controlled study; correlation analysis; cross-sectional study; endocrine disease; endocrine function; female; ferritin blood level; free thyroxine index; gene expression; hemoglobin E-beta thalassemia; high performance liquid chromatography; human; human tissue; hypothyroidism; iron binding capacity; iron load; iron overload; major clinical study; male; nuclear magnetic resonance imaging; prevalence; protein expression; subclinical hypothyroidism; thyroid function; transferrin saturation; transfusion dependent thalassemia |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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732 |
Wahyudi I., Tendi W., Rahman F., Situmorang G.R., Rodjani A. |
36341995300;57208641745;57194287568;57190001213;6504653529; |
Minimal invasive treatment in pelvic-ureteric junction obstruction: A comprehensive review |
2021 |
Research and Reports in Urology |
13 |
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573 |
580 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113146330&doi=10.2147%2fRRU.S268569&partnerID=40&md5=f261d4ed92d593ac62f22ee1c4284d26 |
Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wahyudi, I., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tendi, W., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahman, F., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Situmorang, G.R., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pelvic-ureteric junction obstruction (PUJO) is a common condition, and one of the lead causes of hydronephrosis in children. Currently, the gold standard treatment of PUJO is open surgery using the Anderson–Hynes-modified dismembered pyeloplasty technique. However, with the advancement of medical technology, several minimal invasive approaches were developed, including endoscopic, laparoscopic, and robotic approach, from which the best choice of surgical technique was yet to be determined. Considering the advantages and disadvantages of these methods, the recommended option is to tailor the best surgical approach to each individual patient, and to the surgeons’ preference and experience. Considering these recent advances, a new algorithm is proposed to choose the best minimal invasive modalities invasive treatment to treat PUJO. © 2021 Wahyudi et al. |
Anderson–Hynes dismembered pyeloplasty; Hydronephrosis; Minimal invasive; PUJO |
child; endoscopic surgery; human; hydronephrosis; laparoscopic surgery; minimally invasive surgery; open surgery; pyeloplasty; Review; robot assisted surgery; surgeon; surgical approach; ureteropelvic junction obstruction |
Dove Medical Press Ltd |
22532447 |
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Review |
Q2 |
506 |
9983 |
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735 |
Librianto D., Suwarto S., Imran D., Pramukti H., Saleh I., Ipang F., Utami W.S., Aprilya D. |
57192894799;8443626100;57226756146;57223395589;57191511801;57226749417;57226736196;57193710642; |
An extremely rare case of upper thoracic salmonella infection |
2021 |
Orthopedic Research and Reviews |
13 |
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107 |
112 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112502092&doi=10.2147%2fORR.S319616&partnerID=40&md5=02436420140f9c1ad84a7f2eb880eee2 |
Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Department of Neurology, Pondok Indah Hospital, Jakarta, Indonesia |
Librianto, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Suwarto, S., Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Imran, D., Department of Neurology, Pondok Indah Hospital, Jakarta, Indonesia; Pramukti, H., Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Saleh, I., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ipang, F., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Utami, W.S., Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Vertebral osteomyelitis is rare. Finding the right etiological agent is important to administer antibiotic regimen accordingly. The occurrence of this disease in endemic countries raises the susceptibility of a more common infection such as tuberculosis and pyogenic bacteria. Salmonella spp. infection is also common in endemic countries; however, extra-intestinal manifestation is very rare. Methods: We present an extremely rare case of salmonella vertebral osteomyelitis (SVO) in the upper thoracic vertebrae of a 64-year-old patient with history of cardiac surgery and other pre-existing comorbidities. SVO was treated by antibiotics, surgical debridement and spinal stabilization. Results: Three weeks after surgery and intravenous antibiotics, the patient recovered and was discharged without fever and back pain, with excellent motoric improvement. Conclusion: Salmonella infection must be considered to be one of possible etiological agents in patients with suggestive spondylitis in emerging countries, especially in those with comorbidities. © 2021 Librianto et al. |
Osteomyelitis; Salmonella; Spondylitis; Thoracic spine |
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Dove Medical Press Ltd |
11791462 |
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Article |
Q2 |
707 |
7037 |
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744 |
Rinaldi I., Sari R.M., Tedhy V.U., Winston K. |
23475122400;57208474079;57226362042;57224165400; |
Leukapheresis does not improve early survival outcome of acute myeloid leukemia with leukostasis patients – A dual-center retrospective cohort study |
2021 |
Journal of Blood Medicine |
12 |
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623 |
633 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111261844&doi=10.2147%2fJBM.S312140&partnerID=40&md5=ef2e5f0e39b0ea908c07e71bba0bf1a4 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari, R.M., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tedhy, V.U., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Leukostasis is a medical emergency with high mortality which often occurs in acute myeloid leukemia patients with hyperleukocytosis. One of the therapies that can be used for leukostasis in acute myeloid leukemia is leukapheresis. However, whether leukapheresis can provide better survival benefit when compared with patients not receiving leukapheresis is still unclear. Hence, we aimed to evaluate the effect of chemotherapy plus leukapheresis combination versus chemotherapy only on 28-day survival of acute myeloid leukemia patients with leukostasis. Methods: This study was a dual-center retrospective cohort using secondary data from medical records collected from November 2018 to March 2019. Inclusion criteria were adult patients aged 18 years old or above, diagnosed with acute leukemia with hyperleukocytosis status defined by WBC count greater than 100,000/uL, and with symptoms of leukostasis. One-month survival analysis was conducted using Kaplan–Meier curve method. Univariate and multivariate analyses were then conducted using Cox proportional hazards model to obtain value of hazard ratio (HR) with a 95% confidence interval (CI). Results: A total of 38 patients were obtained for analysis. The median overall survival was 25 days (95% CI: 17.001–32.999 days) in the chemotherapy only group and 20 days (95% CI: 1.497–38.503) in the chemotherapy with leukapheresis group. The use of leukapheresis did not affect 28-day survival (HR: 1.140; 95% CI: 0.396–3.283; p value: 0.809) and 7-day survival (HR: 1.073; 95% CI: 0.277–4.152; p value: 0.919). In the multivariate analysis, age ≥60 years, blast percentage ≥90%, creatinine ≥1.4 mg/dL, and presence of disseminated intravascular coagulation were associated with worse 28-day survival. Conclusion: AML patients with leukostasis who received both chemotherapy and leuka-pheresis did not have better 28-day survival and 7-day survival when compared with patients receiving chemotherapy only. Old age, high blast percentage, high creatinine, and presence of disseminated intravascular coagulation were prognostic factors for worse 28-day survival. © 2021 Rinaldi et al. |
Chemotherapy; Hyperleukocytosis; Leukapheresis; Leukemia; Leukostasis; Survival |
creatinine; gluconate calcium; hemoglobin; lactate dehydrogenase; vascular cell adhesion molecule 1; acute myeloid leukemia; adult; allogeneic hematopoietic stem cell transplantation; Article; blood transfusion; cancer prognosis; chronic myeloid leukemia; clinical article; cohort analysis; de novo acute myeloid leukemia; dyspnea; female; heart failure; human; hypertension; hypocalcemia; Kaplan Meier method; leukapheresis; leukocyte count; leukocytosis; leukostasis; lymphocyte count; male; mean corpuscular hemoglobin; mean corpuscular volume; mean platelet volume; observational study; overall survival; platelet count; platelet lymphocyte ratio; pneumothorax; red blood cell distribution width; retrospective study; risk factor; thrombocyte aggregation |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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