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864 |
Indriyani, Liem I.K., Wuyung P.E., Adnindya M.R., Nasution A.A., Wardiansah, Jusuf A.A. |
57195988823;55802927800;57192889605;57195990858;57195984460;57222188547;57192275719; |
The dynamic of afamin and alpha-fetoprotein expression during rat liver development |
2021 |
OnLine Journal of Biological Sciences |
21 |
1 |
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26 |
32 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101833482&doi=10.3844%2fojbsci.2021.26.32&partnerID=40&md5=63694adea4e7ba46c95652e49c319ed0 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Indonesia; Departement of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Bengkulu, Bengkulu, Indonesia; Departement of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Indriyani, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Indonesia; Wuyung, P.E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Departement of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adnindya, M.R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Nasution, A.A., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Bengkulu, Bengkulu, Indonesia; Wardiansah, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Jusuf, A.A., Departement of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liver has a high level of Alpha-fetoprotein which is assumed to be important for mammalian development. However, Alpha-fetoprotein knockout studies in mice suggested that despite the absence of Alpha-fetoprotein, mice developed normally; the only abnormality observed was infertility in female mice. There are indications that Afamin, a protein that has a gene sequence located on the same chromosome as Alpha-fetoprotein, may compensate for the absence of Alpha-fetoprotein during embryonic development. Nevertheless, research on the dynamics of Afamin expression and its correlation with Alpha-fetoprotein has not been reported. Therefore, it has been done a baseline study to determine the pattern and distribution of Alpha-fetoprotein expression and its correlation with Afamin expression in the developing rat liver. An analytic observational study was performed to study the expression of Afamin and Alpha-fetoprotein in the rat embryos (embryonic day/ED12.5, ED14.5, ED16.5, ED18.5), neonates and adults using an immunohistochemistry technique by assessing the location and intensity of expression using the Immunohistochemistry Optical density score. Afamin started to express in ED18.5 and was evenly distributed in the hepatocytes and was maintained until adulthood. Whereas, Alpha-fetoprotein has been seen at ED12.5 and was distributed evenly in the hepatoblast. At ED18.5, Alpha-fetoprotein expression reached a peak and decreased dramatically after birth. Spearman correlation test showed that both proteins' expressions were correlated in the opposite direction (P<0.05 and r =-0.695). In conclusion, Afamin and Alpha-fetoprotein have an opposite expression during development. The time point of intersection was ED18.5; implying the peak of hepatoblast proliferation to enter the differentiation process. © 2021 Indriyani, Isabella Kurnia Liem, Puspita Eka Wuyung, Msy Rulan Adnindya, Ahmad Azmi Nasution, Wardiansah and Ahmad Aulia Jusuf. |
Afamin; Alpha-Fetoprotein; Hepatoblast; Hepatocytes; Liver Development |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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868 |
Adhimulia K.J., Alfariq L., Kamal A.F. |
57222107905;57222109165;56648996700; |
Atypical telangiectatic osteosarcoma |
2021 |
Formosan Journal of Surgery |
54 |
1 |
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28 |
31 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101461287&doi=10.4103%2ffjs.fjs_63_20&partnerID=40&md5=455cb3287eb4bb8748ca09335f8c6946 |
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, University of Indonesia, Jakarta, Indonesia; Division of Orthopedic Oncology, Department of Orthopedic and Traumatology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, University of Indonesia, Jakarta, Indonesia |
Adhimulia, K.J., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Alfariq, L., Department of Orthopedic and Traumatology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, University of Indonesia, Jakarta, Indonesia; Kamal, A.F., Division of Orthopedic Oncology, Department of Orthopedic and Traumatology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, University of Indonesia, Jakarta, Indonesia |
Telangiectatic osteosarcoma (TOS) is a rare malignant bone tumor. The main clinical and radiological significance of the case presentation is TOS can be easily misdiagnosed as a benign lesion such as an aneurysmal bone cyst (ABC). In this case, we present 63-year-old male with a large mass in the left leg. Imaging modalities were obtained in this patient to define the diagnosis. In this atypical case of TOS, relatively old age presentation, slow-progressing lesion, well-demarcated lesion, and lack of periosteal reaction further accentuate the similarity between TOS and ABC or other benign lesion causing high rate misdiagnosis of TOS. The histopathological examination will finally differentiate TOS from ABC. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Aneurysmal bone cyst; atypical presentation; telangiectatic osteosarcoma |
bone cement; lactate dehydrogenase; adult; aneurysmal bone cyst; arthrodesis; Article; atypical telangiectatic osteosarcoma; bone radiography; case report; clinical article; clinical assessment; clinical feature; comparative study; computer assisted tomography; diagnostic accuracy; diagnostic error; diaphysis; disease exacerbation; epiphysis; erythrocyte sedimentation rate; histopathology; hospital admission; human; knee; laboratory test; male; medical history; metaphysis; middle aged; mitosis; multimodal imaging; neoadjuvant chemotherapy; nuclear magnetic resonance imaging; osteosarcoma; patient referral; periosteum; physical examination; priority journal; proximal tibia; skin edema; skin induration; soft tissue; stroma cell; telangiectasia; thorax radiography; tibialis anterior muscle; t |
Wolters Kluwer Medknow Publications |
1682606X |
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Article |
Q4 |
135 |
24781 |
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869 |
Fabiani H., Mudjihartini N., Lestari W. |
57222097497;57191055759;57222081857; |
Dietary Omega-6 to Omega-3 Fatty Acids Ratio is Correlated with High Molecular Weight Adiponectin Level in Indonesian Office Workers |
2021 |
International Journal of Nutrition, Pharmacology, Neurological Diseases |
11 |
1 |
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64 |
70 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101380278&doi=10.4103%2fijnpnd.ijnpnd-89-20&partnerID=40&md5=7be1b049e89a83256f279f76e4645583 |
Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta, Indonesia; 3Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Fabiani, H., Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta, Indonesia; Mudjihartini, N., 3Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Lestari, W., Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Context: Adiponectin is an adipokine that is secreted by adipocytes and acts to prevent obesity and obesity-related disorders. The high ratio of omega-6 to omega-3 fatty acids in modern dietary habits in working-Age populations, urban areas in particular, is known to play a role in adiponectin secretion. However, previous studies showed inconclusive results. Aim: The study aims to determine the association of the dietary omega-6 to omega-3 fatty acids ratio with adiponectin levels in office workers in Jakarta, Indonesia. Settings and Design: This cross-sectional study included 55 office workers in East Jakarta, Indonesia. Methods: Data were collected via questionnaire, 3-day food record, anthropometric measurement, and serum collection. Statistical analysis used: Independent t test was applied to assess the relationship between subjects characteristics and dietary intake with high molecular weight adiponectin levels. Association of dietary omega-6/omega-3 fatty acids ratio and adiponectin were evaluated using Pearson correlation test (P < 0.05). Results: There is no statistically significant difference in adiponectin levels based on waist circumference category, as well as categories of physical activity, household income levels, total energy, and total fat intake. Conversely, in female subjects (P = 0.000), subjects with normal body mass index (P = 0.000), higher education levels (P = 0.031), and nonsmoking subjects (P = 0.019), significantly higher adiponectin levels are obtained. The ratio of dietary omega-6/omega-3 fatty acids is negatively correlated with adiponectin (P = 0.004, r =-0.383). Conclusions: The decrease in the ratio of omega-6/omega-3 fatty acids is inversely related to higher level of adiponectin, indicating that dietary changes may potentially play a role in prevention strategies for obesity and obesity-related diseases. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
HMW adiponectin; obesity; omega-3 fatty acid; omega-6 fatty acid; workers |
adiponectin; omega 3 fatty acid; omega 6 fatty acid; adult; Article; body mass; caloric intake; cross-sectional study; cytokine release; data analysis software; dietary intake; educational status; fat intake; female; food frequency questionnaire; household income; human; Indonesia; male; metabolic equivalent; molecular weight; non-smoker; obesity; office worker; physical activity; protein expression; sex difference; waist circumference |
Wolters Kluwer Medknow Publications |
22310738 |
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Article |
Q4 |
177 |
20903 |
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877 |
Negara J.D.K., Mudjianto S., Budikayanti A., Adhitya Nugraha P.P. |
57221389254;57193794731;57194713932;57221981778; |
The effect of gamma wave optimization and attention on hitting skills in softball |
2021 |
International Journal of Human Movement and Sports Sciences |
9 |
1 |
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103 |
109 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100846277&doi=10.13189%2fsaj.2021.090114&partnerID=40&md5=572b9a6bf2d4f86222486dfb5b12188a |
Department of Sport Education, Faculty of Sport Education and Health, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
Negara, J.D.K., Department of Sport Education, Faculty of Sport Education and Health, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia; Mudjianto, S., Department of Sport Education, Faculty of Sport Education and Health, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia; Budikayanti, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia; Adhitya Nugraha, P.P., Department of Sport Education, Faculty of Sport Education and Health, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia |
Hitting the ball is a complicated ability in softball academicie, because in appreciation to prioritizing movement skills, cognitive appearances additionally need to be investigated, one of which is attention. Meanwhile, going to hit the ball requires excellent attention for an individual student. Exhibiting gamma waves further influence arrangements of hitting performance. The objectives of this study were first, to determine the negative functional correlation between gamma brain waves and hitting skills, then second to know the positive functional correlation between attention and hitting skills and third to determine the effect of attention on increasing hitting skills. The method used in this research is an experimental method with a one-group pretest-posttest design research design. The sampling technique in this study was using a saturated sampling technique. This investigation amounted to 20 subjects, in the calculation of the Pearson product-moment correlation test using SPSS v.23. The first results collected were p-value 0.026 with an r square value of 0.25, so there is a significant negative functional correlation between gamma brain waves and hitting skills in softball learning of 25%. The second issue obtained p-value 0.017 with an r square value of 0.28, so there is a significant positive functional correlation between attention and hitting skills in softball learning by 28%. Furthermore, thirdly, the results obtained p-value 0.0001 between pre-test and post-test, with a significant increase in skills of 70.17%, so there is a significant influence between attention and hitting skills. © 2021 by authors, all rights reserved. |
Attention; Gamma Brain Waves; Hitting Skills; Softball Games |
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Horizon Research Publishing |
23814381 |
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Article |
Q4 |
132 |
25155 |
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880 |
Putri T.P., Dewi I.A.T.K., Permata T.B.M., Nuryadi E., Kodrat H., Wibowo H., Louisa M., Gondhowiardjo S.A. |
57221919322;57221917792;57197808751;57197806814;57210639849;57217690943;41461551400;6508327402; |
A mini systematic review: Eucheuma cottonii, a red algae, as a radiosensitizer? |
2021 |
Tropical Journal of Natural Product Research |
5 |
1 |
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7 |
15 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100549316&doi=10.26538%2ftjnpr%2fv5i1.2&partnerID=40&md5=0849f73cb51c327672dca7dbaca3460f |
Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Diagnostic and Research Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Putri, T.P., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dewi, I.A.T.K., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wibowo, H., Diagnostic and Research Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutic, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Radiosensitizers assist radiotherapy in providing greater tumor inactivation. Currently there is a search for natural radiosensitizer components which are expected to provide lesser side effects than chemical radiosensitizers. Eucheuma cottonii is a plant with antioxidant and anti-tumor effects. This review aims to search for the potential use of Eucheuma cottonii as a radiosensitizer. This is a mixed review study, where the main component is a systematic review and then followed by a narrative review. This review suggests that Eucheuma cottonii has the potential to become a radiosensitizer, by interfering with the cell cycle control mechanisms and reactivation of p53. Further research is needed to explore the synergistic effect of the combined use of radiotherapy and Eucheuma cottonii. © 2021 Putri et al. |
Anti-tumour; Eucheuma cottonii; Immunomodulator; Radiosensitizer |
antineoplastic agent; birc5 protein; carrageenan; CD4 antigen; CD8 antigen; checkpoint kinase 1; cyclin dependent kinase inhibitor; Eucheuma cottonii extract; gamma interferon; immunomodulating agent; interleukin 4; mouse double minute 2 homolog; plant extract; programmed death 1 ligand 1; protein bcl 2; protein p21; protein p53; radiosensitizing agent; survivin; unclassified drug; antiapoptotic activity; antineoplastic activity; antioxidant activity; antiproliferative activity; apoptosis; cancer cell line; cell cycle regulation; cytotoxicity; gene expression; human; IC50; in vitro study; in vivo study; Kappaphycus alvarezii; MTT assay; neoplasm; nonhuman; phagocytosis; protein expression; radiosensitization; randomized controlled trial (topic); Review; synergistic effect; systematic revie |
Faculty of Pharmacy, University of Benin |
26160684 |
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Review |
Q4 |
127 |
25832 |
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892 |
Dwinata M., Putera D.D., Hasan I., Raharjo M. |
57209231012;57210288025;12776850800;57212400550; |
SGLT2 inhibitors for improving hepatic fibrosis and steatosis in non-alcoholic fatty liver disease complicated with type 2 diabetes mellitus: a systematic review |
2021 |
Clinical and Experimental Hepatology |
6 |
4 |
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339 |
346 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099931230&doi=10.5114%2fceh.2020.102173&partnerID=40&md5=628a477d8f6d02f9de989db2ce816c8c |
Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Dwinata, M., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Putera, D.D., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Raharjo, M., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Aim of the study: To evaluate the efficacy of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in improving hepatic fibrosis and steatosis of non-alcoholic fatty liver disease (NAFLD) patients with type 2 diabetes mellitus (T2DM). Material and methods: We searched CENTRAL, MEDLINE, and EMBASE and included any clinical trials involving patients with NAFLD and T2DM aged ≥ 18 years comparing efficacy of SGLT2i and other antidiabetic drugs in improving fibrosis and steatosis, irrespective of publication status, year of publication, and language. Results: Five clinical trials were included. One study reported significant improvements in the controlled attenuation parameter 314.6 ±61.0 dB/m to 290.3 ±72.7 dB/m (p = 0.04) in the SGLT2i group measured by transient elastography. In patients with significant fibrosis, dapagliflozin treatment significantly decreased the liver stiffness measurement from 14.7 ±5.7 kPa at baseline to 11.0 ±7.3 kPa after 24 weeks (p = 0.02). One study reported a significant decrease in liver fat content 16.2% to 11.3% (p < 0.001) in the SGLT2i group compared to the control (p < 0.001). Three studies reported significant improvement in the liver-to-spleen ratio in the SGLT2i group after treatment 0.96 (0.86-1.07) to 1.07 (0.98-1.14), p < 0.01, 0.80 ±0.24 to 1.00 ±0.18, p < 0.001, and 0.91 (0.64-1.04) to 1.03 (0.80-1.20), p < 0.001 respectively. All studies reported a significant decrease in alanine aminotransferase with SGLT2i. Conclusions: SGLT2i is associated with positive effects on hepatic steatosis measured by non-invasive modalities. Further studies are needed to confirm the impact of SGLT2i on hepatic fibrosis and steatosis. © 2020 Termedia Publishing House Ltd.. All rights reserved. |
Diabetes mellitus; Fibrosis; NAFLD; SGLT2 inhibitor; Steatosis |
alanine aminotransferase; dapagliflozin; empagliflozin; ipragliflozin; luseogliflozin; metformin; pioglitazone; sodium glucose cotransporter 2 inhibitor; adult; aged; alanine aminotransferase blood level; Article; comparative effectiveness; controlled study; diabetic patient; drug efficacy; elastography; female; human; liver fibrosis; liver stiffness; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; quasi experimental study; randomized controlled trial; systematic review; transient elastography; treatment outcome |
Termedia Publishing House Ltd. |
23921099 |
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Article |
Q4 |
394 |
12273 |
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