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Castro-Calvo J., King D.L., Stein D.J., Brand M., Carmi L., Chamberlain S.R., Demetrovics Z., Fineberg N.A., Rumpf H.-J., Yücel M., Achab S., Ambekar A., Bahar N., Blaszczynski A., Bowden-Jones H., Carbonell X., Chan E.M.L., Ko C.-H., de Timary P., Dufour M., Grall-Bronnec M., Lee H.K., Higuchi S., Jimenez-Murcia S., Király O., Kuss D.J., Long J., Müller A., Pallanti S., Potenza M.N., Rahimi-Movaghar A., Saunders J.B., Schimmenti A., Lee S.-Y., Siste K., Spritzer D.T., Starcevic V., Weinstein A.M., Wölfling K., Billieux J. |
55883443800;57214845145;55769747595;7202584047;56059576800;24723599200;55882733400;35413253200;7004528536;7006258831;43860942100;35749590300;56118752900;57220353000;15834239200;35232657000;35344453600;8716479100;25821757600;7103106444;57209334001;8600274900;7202930847;7801631922;57000322900;41762055600;57190689045;56472199900;57207496581;7006591634;8696686900;7402341830;36089370500;36760834000;55644113100;24463790800;7005374306;7201680411;23973806500;57220421868; |
Expert appraisal of criteria for assessing gaming disorder: an international Delphi study |
2021 |
Addiction |
116 |
9 |
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2463 |
2475 |
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24 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099942594&doi=10.1111%2fadd.15411&partnerID=40&md5=284445a20e0a947af8166f3091d96aea |
Department of Personality, Assessment, and Psychological Treatments, University of Valencia, Spain; College of Education, Psychology, and Social Work, Flinders University, Australia; SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa; General Psychology: Cognition and Center for Behavioral Addiction Research (CeBAR), University Duisburg-Essen, Germany; The Data Science Institute, Inter-disciplinary Center, Herzliya, Israel; Department of Psychiatry, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Southern Health NHS Foundation Trust, Southampton, United Kingdom; Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary; University of Hertfordshire, Hatfield, UK, Hertfordshire Partnership University NHS Foundation Trust, Welwyn Garden City, United Kingdom; University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany; BrainPark, School of Psychological Sciences, Turner Institute for Brain and Mental Health and Monash Biomedical Imaging Facility, Monash University, Melbourne, VIC, Australia; Specialized Facility In Behavioral Addictions, ReConnecte, Department of Psychiatry, University Hospitals of Geneva, Generva, Switzerland; Faculty of Medicine, Geneva University, Geneva, Switzerland; National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India; Department of Psychiatry and Mental Health, Hospital Selayang, Ministry of Health, Malaysia; Faculty of Science, Brain and Mind Centre, School of Psychology, University of Sydney, Sydney, Australia; National Centre for Gaming Disorders, London, United Kingdom; University College London, London, United Kingdom; Faculty of Psychology, Education and Sports Sciences Blanquerna, Ramon Llull University, Barcelona, Spain; St John's Cathedral Counselling Service, and Division on Addiction, Hong Kong; Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan; Department of Adult Psychiatry, Institute of Neuroscience, UCLouvain and Cliniques Universitaires Saint-Luc, Brussels, Belgium; Université du Québec à Montréal, Montréal, QC, Canada; CHU Nantes, Department of Addictology and Psychiatry, Nantes, France; Universités de Nantes et Tours, UMR 1246, Nantes, France; Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; National Hospital Organization, Kurihama Medical and Addiction Center, Japan; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain; Ciber Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain; International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, United Kingdom; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Laboratory for Experimental Psychopathology, Psychological Science Research Institute, Université Catholique de Louvain, Louvain, Belgium; Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hanover, Germany; Neuroscience Institute, University of Florence, Italy; Departments of Psychiatry and Neuroscience and the Child Study Center, Yale School of Medicine and Connecticut Mental Health Center, New Haven, CT, United States; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Centre for Youth Substance Abuse Research, University of Queensland, Brisbane, QLD, Australia; Faculty of Human and Social Sciences, Kore University of Enna, Enna, Italy; Department of Psychiatry, Eunpyeong St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Postgraduate Program in Psychiatry and Behavioral Sciences, Federal University of Rio Grande do Sul, Brazil; Faculty of Medicine and Health, Sydney Medical School, Nepean Clinical School, University of Sydney, Sydney, Australia; Department of Behavioral Science, Ariel University, Israel; Outpatient Clinic for Behavioral Addictions, Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Institute of Psychology, University of Lausanne, Lausanne, Switzerland; Health and Behaviour Institute, University of Luxembourg, Esch-sur-Alzette, Luxembourg |
Castro-Calvo, J., Department of Personality, Assessment, and Psychological Treatments, University of Valencia, Spain; King, D.L., College of Education, Psychology, and Social Work, Flinders University, Australia; Stein, D.J., SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa; Brand, M., General Psychology: Cognition and Center for Behavioral Addiction Research (CeBAR), University Duisburg-Essen, Germany; Carmi, L., The Data Science Institute, Inter-disciplinary Center, Herzliya, Israel; Chamberlain, S.R., Department of Psychiatry, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, Southern Health NHS Foundation Trust, Southampton, United Kingdom; Demetrovics, Z., Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary; Fineberg, N.A., University of Hertfordshire, Hatfield, UK, Hertfordshire Partnership University NHS Foundation Trust, Welwyn Garden City, United Kingdom, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Rumpf, H.-J., Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany; Yücel, M., BrainPark, School of Psychological Sciences, Turner Institute for Brain and Mental Health and Monash Biomedical Imaging Facility, Monash University, Melbourne, VIC, Australia; Achab, S., Specialized Facility In Behavioral Addictions, ReConnecte, Department of Psychiatry, University Hospitals of Geneva, Generva, Switzerland, Faculty of Medicine, Geneva University, Geneva, Switzerland; Ambekar, A., National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India; Bahar, N., Department of Psychiatry and Mental Health, Hospital Selayang, Ministry of Health, Malaysia; Blaszczynski, A., Faculty of Science, Brain and Mind Centre, School of Psychology, University of Sydney, Sydney, Australia; Bowden-Jones, H., National Centre for Gaming Disorders, London, United Kingdom, University College London, London, United Kingdom; Carbonell, X., Faculty of Psychology, Education and Sports Sciences Blanquerna, Ramon Llull University, Barcelona, Spain; Chan, E.M.L., St John's Cathedral Counselling Service, and Division on Addiction, Hong Kong; Ko, C.-H., Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan; de Timary, P., Department of Adult Psychiatry, Institute of Neuroscience, UCLouvain and Cliniques Universitaires Saint-Luc, Brussels, Belgium; Dufour, M., Université du Québec à Montréal, Montréal, QC, Canada; Grall-Bronnec, M., CHU Nantes, Department of Addictology and Psychiatry, Nantes, France, Universités de Nantes et Tours, UMR 1246, Nantes, France; Lee, H.K., Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Higuchi, S., National Hospital Organization, Kurihama Medical and Addiction Center, Japan; Jimenez-Murcia, S., Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain, Ciber Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain; Király, O., Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary; Kuss, D.J., International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, United Kingdom; Long, J., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Laboratory for Experimental Psychopathology, Psychological Science Research Institute, Université Catholique de Louvain, Louvain, Belgium; Müller, A., Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hanover, Germany; Pallanti, S., Neuroscience Institute, University of Florence, Italy; Potenza, M.N., Departments of Psychiatry and Neuroscience and the Child Study Center, Yale School of Medicine and Connecticut Mental Health Center, New Haven, CT, United States; Rahimi-Movaghar, A., Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Saunders, J.B., Centre for Youth Substance Abuse Research, University of Queensland, Brisbane, QLD, Australia; Schimmenti, A., Faculty of Human and Social Sciences, Kore University of Enna, Enna, Italy; Lee, S.-Y., Department of Psychiatry, Eunpyeong St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Spritzer, D.T., Postgraduate Program in Psychiatry and Behavioral Sciences, Federal University of Rio Grande do Sul, Brazil; Starcevic, V., Faculty of Medicine and Health, Sydney Medical School, Nepean Clinical School, University of Sydney, Sydney, Australia; Weinstein, A.M., Department of Behavioral Science, Ariel University, Israel; Wölfling, K., Outpatient Clinic for Behavioral Addictions, Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Billieux, J., Institute of Psychology, University of Lausanne, Lausanne, Switzerland, Health and Behaviour Institute, University of Luxembourg, Esch-sur-Alzette, Luxembourg |
Background and aims: Following the recognition of ‘internet gaming disorder’ (IGD) as a condition requiring further study by the DSM-5, ‘gaming disorder’ (GD) was officially included as a diagnostic entity by the World Health Organization (WHO) in the 11th revision of the International Classification of Diseases (ICD-11). However, the proposed diagnostic criteria for gaming disorder remain the subject of debate, and there has been no systematic attempt to integrate the views of different groups of experts. To achieve a more systematic agreement on this new disorder, this study employed the Delphi expert consensus method to obtain expert agreement on the diagnostic validity, clinical utility and prognostic value of the DSM-5 criteria and ICD-11 clinical guidelines for GD. Methods: A total of 29 international experts with clinical and/or research experience in GD completed three iterative rounds of a Delphi survey. Experts rated proposed criteria in progressive rounds until a pre-determined level of agreement was achieved. Results: For DSM-5 IGD criteria, there was an agreement both that a subset had high diagnostic validity, clinical utility and prognostic value and that some (e.g. tolerance, deception) had low diagnostic validity, clinical utility and prognostic value. Crucially, some DSM-5 criteria (e.g. escapism/mood regulation, tolerance) were regarded as incapable of distinguishing between problematic and non-problematic gaming. In contrast, ICD-11 diagnostic guidelines for GD (except for the criterion relating to diminished non-gaming interests) were judged as presenting high diagnostic validity, clinical utility and prognostic value. Conclusions: This Delphi survey provides a foundation for identifying the most diagnostically valid and clinically useful criteria for GD. There was expert agreement that some DSM-5 criteria were not clinically relevant and may pathologize non-problematic patterns of gaming, whereas ICD-11 diagnostic guidelines are likely to diagnose GD adequately and avoid pathologizing. © 2021 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. |
Delphi; diagnosis; DSM; gaming disorder; ICD; internet gaming disorder |
addiction; Delphi study; Diagnostic and Statistical Manual of Mental Disorders; human; impulse control disorder; Internet; video game; Behavior, Addictive; Delphi Technique; Diagnostic and Statistical Manual of Mental Disorders; Disruptive, Impulse Control, and Conduct Disorders; Humans; Internet; Video Games |
John Wiley and Sons Inc |
09652140 |
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33449441 |
Article |
Q1 |
2424 |
961 |
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7 |
Wisnu W., Alwi I., Nafrialdi N., Harimurti K., Pemayun T.G.D., Jusman S.W.A., Santoso D.I.S., Harahap A.R., Suwarto S., Subekti I. |
57200425452;15055173800;57395824800;23473513200;57208091289;36518792100;6604001213;57395521700;8443626100;24336854300; |
The Differential Effects of Propylthiouracil and Methimazole as Graves’ Disease Treatment on Vascular Atherosclerosis Markers: A Randomized Clinical Trial |
2021 |
Frontiers in Endocrinology |
12 |
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796194 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122186237&doi=10.3389%2ffendo.2021.796194&partnerID=40&md5=f92b3a12a849c6a2e102b7358c8abd20 |
Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Endocrine, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Wisnu, W., Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nafrialdi, N., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harimurti, K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pemayun, T.G.D., Division of Endocrine, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Santoso, D.I.S., Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harahap, A.R., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Suwarto, S., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Subekti, I., Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Hyperthyroidism is related to vascular atherosclerosis. Propylthiouracil (PTU) and methimazole, other than their antithyroid effects, may have different mechanisms in preventing atherogenesis in Graves’ disease. Objective: This study aimed to investigate the effect of antithyroid drugs on markers of vascular atherosclerosis in Graves’ hyperthyroidism. Methods: This study was a single-blind, randomized clinical trial conducted on 36 patients with Graves’ disease in Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from June 2019 until July 2020. Graves’ disease was diagnosed from clinical manifestation of hyperthyroidism with diffuse goiter and then confirmed by thyroid stimulation hormone (TSH), free T4 (fT4), and TSH-receptor antibody (TRAb) measurements. Participants were randomly assigned to either a PTU or a methimazole treatment group and followed up for 3 months. Markers of vascular atherosclerosis were represented by adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin], carotid artery stiffness [pulse wave velocity (PWV)], and thickness [carotid intima media thickness (cIMT)]. Results: By the end of the study, 24 participants reached euthyroid condition (13 from the PTU group and 11 from the methimazole group). After 3 months of follow-up, in the PTU group, we noticed an improvement of ICAM-1 [pretreatment: 204.1 (61.3) vs. posttreatment: 141.6 (58.4) ng/ml; p = 0.001], VCAM-1 [837 (707–977) vs. 510 (402–630) ng/ml; p < 0.001] and E-selectin [32.1 (24.1–42.7) vs. 28.2 (21.6–36.8) ng/ml; p = 0.045] in the PTU group. In the methimazole group, only VCAM-1 improvement [725 (565–904) vs. 472 (367–590); p = 0.001] was observed. Meanwhile, we found no significant changes in PWV or cIMT in either group. Conclusion: Antithyroid treatment in Graves’ disease leads to improvement in adhesion molecules, with a lesser effect on methimazole, whereas there were no significant changes in PWV or cIMT. PTU may have a better mechanism compared with methimazole in terms of improving adhesion molecules. Copyright © 2021 Wisnu, Alwi, Nafrialdi, Harimurti, Pemayun, Jusman, Santoso, Harahap, Suwarto and Subekti. |
adhesion molecules; carotid intima media thickness; Graves’ disease; hyperthyroidism; methimazole; propylthiouracil; pulse wave velocity; vascular atherosclerosis |
cell adhesion molecule 1; endothelial leukocyte adhesion molecule 1; propylthiouracil; thiamazole; thyrotropin; adolescent; adult; arterial stiffness; Article; atherosclerosis; blood pressure; clinical article; controlled study; coronavirus disease 2019; echography; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; female; follow up; Graves disease; human; hyperthyroidism; inflammation; male; middle aged; physical examination; pregnancy; pulse wave velocity; randomized controlled trial; young adult |
Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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39 |
Marofi F., Kozlitina I.A., Margiana R., Bahramali M., Suksatan W., Abdelbasset W.K., Chupradit S., Nasimi M., Maashi M.S. |
57199650994;57428645300;56685900600;57365531600;57219950613;57208873763;57211329338;57189347372;57220613490; |
MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy |
2021 |
Stem Cell Research and Therapy |
12 |
1 |
597 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120732728&doi=10.1186%2fs13287-021-02662-6&partnerID=40&md5=1bb65103a59b38f350d6be8213b4dad8 |
Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Sechenov First Moscow State Medical University, Moscow, Russian Federation; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biotechnology Department, University of Tehran, Tehran, Iran; Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Tehran University of Medical Sciences, Tehran, Iran; Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Kozlitina, I.A., Sechenov First Moscow State Medical University, Moscow, Russian Federation; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bahramali, M., Biotechnology Department, University of Tehran, Tehran, Iran; Suksatan, W., Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Nasimi, M., Tehran University of Medical Sciences, Tehran, Iran; Maashi, M.S., Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regeneration. Further, due to their great potential to stimulate angiogenesis and also facilitate matrix remodeling, MSCs hold substantial potential as future therapeutic strategies in this context. The MSCs-induced wound healing is thought to mainly rely on the secretion of a myriad of paracrine factors in addition to their direct differentiation to skin-resident cells. Besides, MSCs-derived exosomes as nanoscale and closed membrane vesicles have recently been suggested as an effective and cell-free approach to support skin regeneration, circumventing the concerns respecting direct application of MSCs. The MSCs-derived exosomes comprise molecular components including lipid, proteins, DNA, microRNA, and also mRNA, which target molecular pathways and also biological activities in recipient cells (e.g., endothelial cell, keratinocyte, and fibroblast). The secreted exosome modifies macrophage activation, stimulates angiogenesis, and instigates keratinocytes and dermal fibroblast proliferations as well as migrations concurrently regulate inherent potential of myofibroblast for adjustment of turnover of the ECM. In the present review, we will focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports. © 2021, The Author(s). |
Cutaneous wounds; Differentiation; Exosome; Mesenchymal stem/stromal stem cell (MSC); Paracrine factors |
angiopoietin 1; angiopoietin 2; biomaterial; chemokine receptor CCR2; chemokine receptor CCR3; chemokine receptor CXCR1; chemokine receptor CXCR4; collagen type 1; collagen type 3; elastin; fibroblast growth factor 2; gelatinase B; immunoglobulin enhancer binding protein; interleukin 1; interleukin 6; microRNA; microRNA 21 5p; mitogen activated protein kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; platelet derived growth factor beta receptor; platelet endothelial cell adhesion molecule 1; stromal cell derived factor 1; toll like receptor 4; tumor necrosis factor; unclassified drug; vasculotropin; vasculotropin C; angiogenesis; biogenesis; cell differentiation; cell migration; cell proliferation; diabetic foot; endothelium cell; exosome; extracellular matrix; fibroblast; h |
BioMed Central Ltd |
17576512 |
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34863308 |
Review |
Q1 |
1599 |
2021 |
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62 |
Prasetyo M., Mongan A.E., Chozie N.A., Prihartono J., Setiawan S.I. |
57192905252;57226385960;57194329830;6602605635;57195939543; |
Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence |
2021 |
Insights into Imaging |
12 |
1 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111352122&doi=10.1186%2fs13244-021-01050-1&partnerID=40&md5=7acc2e0c4841079a7e9e49379be1ff9e |
Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Departement of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Mongan, A.E., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Chozie, N.A., Department of Pediatric, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Prihartono, J., Departement of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia |
Background: Repeated bleeding in hemophilic arthropathy (HA) may result in severe degenerative changes and joint destruction. The gradient-recalled echo (GRE) sequence MR is proved to be the best method to detect hemosiderin deposition. However, MR is not widely available in developing countries, including Indonesia. Some studies have proposed ultrasonography (US) as an alternative tool in evaluating hemophilic joint. However, there is still some disagreement on the ability of US to detect hemosiderin deposition. Objective: To evaluate the association between US and GRE-sequence MR imaging in detecting hemosiderin deposition in hemophilic ankle joint. Material and methods: A total of 102 sites from 17 ankle joints of 11 boys with severe hemophilia A underwent US examination using a high-frequency linear array transducer. GRE-sequence MR examination was performed in sagittal view consistent with the sites scanned by US. Both examinations were performed on the same day, but MR interpretation was performed blindly at different times. The association between US and GRE-sequences in detecting hemosiderin deposition was analyzed using McNemar’s test. Results: Statistical analysis showed a significant association (p value < 0.001) between US and GRE MR in detecting hemosiderin deposition, but the association is weak (R = 0.26). Sensitivity and specificity of US for detecting hemosiderin deposition were 46.84% (95%CI: 35.51–58.40) and 95.65% (95%CI: 78.05–99.89), respectively, with positive predictive value 97.37% (95%CI: 84.29–99.61), negative predictive value 34.38% (95%CI: 29.50–39.60) and accuracy 57.84% (95%CI: 47.66–67.56). Conclusion: There was a weak association between US and GRE-sequences in detecting hemosiderin deposition of hemophilic ankle joint. © 2021, The Author(s). |
GRE MR imaging; Hemophilic arthropathy; Hemosiderin deposition; US |
gadolinium; hemosiderin; accuracy; adolescent; anisotropy; Article; child; clinical article; cross-sectional study; echography; gradient recalled echo; gray matter; hemophilic arthropathy; histopathology; human; image analysis; male; medial malleolus; nuclear magnetic resonance imaging; predictive value; sensitivity and specificity; synovectomy |
Springer Science and Business Media Deutschland GmbH |
18694101 |
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Article |
Q1 |
1405 |
2531 |
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69 |
Tamara A., Coulson D.J., Latief J.S., Bakhashab S., Weaver J.U. |
57205305387;57219221240;57219224500;56418579000;57203055590; |
Upregulated anti-angiogenic miR-424-5p in type 1 diabetes (model of subclinical cardiovascular disease) correlates with endothelial progenitor cells, CXCR1/2 and other parameters of vascular health |
2021 |
Stem Cell Research and Therapy |
12 |
1 |
249 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105816910&doi=10.1186%2fs13287-021-02332-7&partnerID=40&md5=90e29bc673c4921f95cd1f09971c9525 |
Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 80218, Saudi Arabia; Department of Diabetes, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, NE9 6SH, United Kingdom; Vascular Biology and Medicine Theme, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom |
Tamara, A., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Coulson, D.J., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom; Latief, J.S., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Bakhashab, S., Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 80218, Saudi Arabia; Weaver, J.U., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Department of Diabetes, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, NE9 6SH, United Kingdom, Vascular Biology and Medicine Theme, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom |
Background: In spite of clinical progress, cardiovascular disease (CVD) remains the predominant cause of mortality worldwide. Overexpression studies in animals have proven miR-424-5p to have anti-angiogenic properties. As type 1 diabetes mellitus (T1DM) without CVD displays endothelial dysfunction and reduced circulating endothelial progenitor cells (cEPCs), it offers a model of subclinical CVD. Therefore, we explored miR-424-5p, cytokines and vascular health in T1DM. Methods: Twenty-nine well-controlled T1DM patients with no CVD and 20-matched controls were studied. Cytokines IL8, TNF-α, IL7, VEGF-C, cEPCs/CD45dimCD34+CD133+ cells and ex-vivo proangiogenic cells (PACs)/fibronectin adhesion assay (FAA) were measured. MiR-424-5p in plasma and peripheral blood mononuclear cells (PBMC) along with mRNAs in PBMC was evaluated. Results: We found an elevation of IL7 (p = 0.008), IL8 (p = 0.003), TNF-α (p = 0.041), VEGF-C (p = 0.013), upregulation of mRNA CXCR1 (p = 0.009), CXCR2 (p < 0.001) and reduction of cEPCs (p < 0.001), PACs (p < 0.001) and FAA (p = 0.017) in T1DM. MiR-424-5p was upregulated in T1DM in PBMC (p < 0.001). MiR-424-5p was negatively correlated with cEPCs (p = 0.006), PACs (p = 0.005) and FAA (p < 0.001) and positively with HbA1c (p < 0.001), IL7 (p = 0.008), IL8 (p = 0.017), VEGF-C (p = 0.007), CXCR1 (p = 0.02) and CXCR2 (p = 0.001). ROC curve analyses showed (1) miR-424-5p to be a biomarker for T1DM (p < 0.001) and (2) significant upregulation of miR-424-5p, defining subclinical CVD, occurred at HbA1c of 46.5 mmol/mol (p = 0.002). Conclusion: We validated animal research on anti-angiogenic properties of miR-424-5p in T1DM. MiR-424-5p may be a biomarker for onset of subclinical CVD at HbA1c of 46.5 mmol/mol (pre-diabetes). Thus, miR-424-5p has potential use for CVD monitoring whilst anti-miR-424-5p-based therapies may be used to reduce CVD morbidity/mortality in T1DM. © 2021, The Author(s). |
CD45dimCD34+CD133+, CXCR1/2; IL8; MiR-424-5p; T1DM |
alanine aminotransferase; biological marker; CD133 antigen; CD34 antigen; CD40 antigen; chemokine receptor CXCR1; chemokine receptor CXCR2; complementary DNA; cyclin D1; cyclooxygenase 2; endothelial leukocyte adhesion molecule 1; fibroblast growth factor 2; gamma interferon inducible protein 10; glucose; hemoglobin A1c; interleukin 10; interleukin 16; interleukin 7; interleukin 8; messenger RNA; microRNA; microRNA 424 5p; PADGEM protein; platelet derived growth factor AA; receptor type tyrosine protein phosphatase C; somatomedin C; tissue inhibitor of metalloproteinase 1; triacylglycerol; tumor necrosis factor; unclassified drug; vasculotropin C; microRNA; MIRN424 microrna, human; adult; alanine aminotransferase blood level; Article; cardiovascular disease; cardiovascular risk; clinical a |
BioMed Central Ltd |
17576512 |
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33985567 |
Article |
Q1 |
1599 |
2021 |
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85 |
Wiguna T., Minayati K., Kaligis F., Ismail R.I., Wijaya E., Murtani B.J., Pradana K. |
24367785700;57218681686;36604651700;55996895500;57358945000;57216652176;57220165625; |
The Effect of Cyberbullying, Abuse, and Screen Time on Non-suicidal Self-Injury Among Adolescents During the Pandemic: A Perspective From the Mediating Role of Stress |
2021 |
Frontiers in Psychiatry |
12 |
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743329 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120410832&doi=10.3389%2ffpsyt.2021.743329&partnerID=40&md5=721d9aa51662421c0092a11d6eaf48a8 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Psychology, Universitas Tarumanegara, Jakarta, Indonesia |
Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wijaya, E., Faculty of Psychology, Universitas Tarumanegara, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pradana, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Adolescence is often a period of turmoil. The COVID-19 pandemic has increased adolescents' difficulty due to mental health consequences that may affect their developmental milestones. This study constructed and empirically tested a theoretical model of three predictive factors (cyberbullying, abuse, and screen time) and stress as the mediating factor in adolescent non-suicidal self-injury (NSSI). Structural equation model (SEM) analysis was applied to investigate stress as a mediating factor in the relationship between adolescent NSSI and cyberbullying, abuse, and screen time. This cross-sectional study used a “crowdsourcing” sample collection method to recruit 464 adolescents aged 11–17 years who were administered a questionnaire comprising scales on cyberbullying, abuse, screen time, stress, and NSSI. All scales had construct reliabilities ranging from 0.759 to 0.958. SEM statistical analysis was performed using Lisrel version 8.8 (Scientific Software International, USA) for Windows (Microsoft Corporation, Redmond, WA, USA). The mean (± SD) age of the cohort was 14.61 ± 1.65 years, and consisted of 66.7% females. Secondary high school was the highest educational background (58%). The study found that cyberbullying and abuse were direct positive predictors (critical t-value for the path > 1.96; p < 0.05) of adolescent NSSI; however, screen time did not have any direct relationship. Furthermore, stress was a significant full mediating factor of screen time and a partial mediating factor of cyberbullying and abuse in the relationship with adolescent NSSI (critical t-value of the path = 5.27; p < 0.05). Cyberbullying, screen time, and abuse with the mediating effect of stress could explain 48% of the variance in adolescent NSSI (R2 = 0.48). Adolescent mental health prevention and promotion programs need to be redesigned during the current COVID-19 pandemic to manage their stress and minimize the mental health consequences of cyberbullying, abuse, and inappropriately increased screen time. Copyright © 2021 Wiguna, Minayati, Kaligis, Ismail, Wijaya, Murtani and Pradana. |
abuse; adolescents; COVID-19; cyberbullying; Indonesia; non-suicidal self-injury; screen time; stress |
abuse; adolescent; Article; automutilation; coronavirus disease 2019; cross-sectional study; cyberbullying; educational status; female; health program; human; male; mental health; pandemic; physiological stress; prediction; questionnaire; screen time |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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89 |
Elbarbary N.S., dos Santos T.J., de Beaufort C., Wiltshire E., Pulungan A., Scaramuzza A.E. |
35725405100;37080460700;55346159500;6603809910;57192905981;6602617288; |
The Challenges of Managing Pediatric Diabetes and Other Endocrine Disorders During the COVID-19 Pandemic: Results From an International Cross-Sectional Electronic Survey |
2021 |
Frontiers in Endocrinology |
12 |
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735554 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119406902&doi=10.3389%2ffendo.2021.735554&partnerID=40&md5=0764f19be86686d381fa20013b41f50b |
Diabetes Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Instituto Hispalense de Pediatría, Vithas Almería, Almería, Spain; Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain; Diabetes Endocrine Care Clinique Pédiatrique (DECCP), Clinique Pédiatrique/Centre Hospitalier (CH) de Luxembourg, Luxembourg; Department Pediatric Endocrinology, Free University Hospital Brussels, Brussels, Belgium; Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand; Department of Child Health, Capital and Coast District Health Board, Wellington, New Zealand; Child Health Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Diabetes and Endocrinology Nutrition, Division of Pediatrics, Azienda Socio Sanitaria Territoriale (ASST) Cremona, “Ospedale Maggiore di Cremona”, Cremona, Italy |
Elbarbary, N.S., Diabetes Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; dos Santos, T.J., Instituto Hispalense de Pediatría, Vithas Almería, Almería, Spain, Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain; de Beaufort, C., Diabetes Endocrine Care Clinique Pédiatrique (DECCP), Clinique Pédiatrique/Centre Hospitalier (CH) de Luxembourg, Luxembourg, Department Pediatric Endocrinology, Free University Hospital Brussels, Brussels, Belgium; Wiltshire, E., Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand, Department of Child Health, Capital and Coast District Health Board, Wellington, New Zealand; Pulungan, A., Child Health Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Scaramuzza, A.E., Diabetes and Endocrinology Nutrition, Division of Pediatrics, Azienda Socio Sanitaria Territoriale (ASST) Cremona, “Ospedale Maggiore di Cremona”, Cremona, Italy |
Background: Frequency, dimensions, management, and outcomes of the COVID-19 pandemic in children with endocrine disorders and diabetes were assessed. Methods: A cross-sectional electronic survey was distributed to the global network of endocrine societies. Respondents’ professional and practice profiles, clinic sizes, their country of practice, and the impact of COVID-19 on endocrine diseases were investigated. Results: Respondents from 131 pediatric endocrine centers in 51 countries across all continents completed the survey. Routine check-ups and education were altered in most pediatric endocrine clinics. Over 20% of clinics experienced a shortage of critical medications or essential supplies. ICU treatment was required for patients with diabetes and COVID-19 in 21.2% of centers. In diabetes, 44% of respondents reported increased diabetic ketoacidosis episodes in newly diagnosed cases and 30% in established cases. Biopsychosocial and behavioral changes were explicitly reported to be occurring among pediatric patients with endocrine disorders. Conclusions: This large global survey conducted during the COVID-19 pandemic highlights that diabetes is more challenging to manage than any other pediatric endocrine disorder, with an increased risk of morbidity. Psychological distress due to COVID-19 needs to be recognized and addressed. The importance of close contact with healthcare professionals should be emphasized, and medical supplies should be readily available to all patients. © Copyright © 2021 Elbarbary, dos Santos, de Beaufort, Wiltshire, Pulungan and Scaramuzza. |
adrenal; children; COVID-19; diabetes; growth; obesity and metabolic syndrome; puberty; thyroid |
anemia; anxiety; Article; behavior change; bone metabolism; child; clinical practice; coronavirus disease 2019; cross-sectional study; depression; diabetes mellitus; diabetic ketoacidosis; eating disorder; education; endocrine disease; female; gender dysphoria; genetic screening; glucose blood level; glycemic control; human; insulin dependent diabetes mellitus; insulin treatment; major clinical study; male; mental stress; metabolic syndrome X; morbidity; pandemic; pediatric patient; pharmacist; physical activity; preschool child; questionnaire; school child; suicide attempt; teleconsultation; thyroid disease |
Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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118 |
Sen L.T., Siste K., Hanafi E., Murtani B.J., Christian H., Limawan A.P., Adrian, Siswidiani L.P. |
57219034101;55644113100;56737010600;57216652176;57209266195;57202712511;57216932703;57219029296; |
Insights Into Adolescents' Substance Use in a Low–Middle-Income Country During the COVID-19 Pandemic |
2021 |
Frontiers in Psychiatry |
12 |
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739698 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118257704&doi=10.3389%2ffpsyt.2021.739698&partnerID=40&md5=9b8aba71c0b6aaab6c7e81012e3c8927 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: The COVID-19 pandemic and its lockdown have been a significant life event for many individuals, particularly adolescents. The immense psychological pressure could drive risky behavior, e.g., substance use, while lockdown might lead to decreased use. This study aimed to observe the change in substance use among adolescents in Indonesia and the moderating variables to consumption during the COVID-19 lockdown period. Methods: This study utilized an online survey from April 28, 2020 to June 30, 2020. The hyperlink was disseminated to school administrators and parenting groups through social media and direct messages. A total of 2,932 adolescents (17.4 ± 2.24 and 78.7% females) submitted valid responses. The survey was comprised of a sociodemographic section, substance use details, and psychometric sections, including the Alcohol Use Disorders Identification Test (AUDIT), Cigarette Dependence Scale 12 (CDS-12), Pittsburgh Sleep Quality Index (PSQI), and Strength and Difficulties Questionnaire (SDQ). Results: Overall, adolescent alcohol use during the pandemic was 5.1%, cigarette smoking was 3.1%, and drug consumption was 0.4%. Over half (53.4%) of alcohol drinkers reported increased drinking, and 33.1% had harmful or dependence-like drinking behavior; in contrast, 44.4% of adolescent smokers disclosed reduced cigarette consumption. Around 37.8% of the drug users indicated increased use. During the pandemic, adolescent alcohol use was associated with higher education [adjusted odds ratio (AOR) = 2.67, 95% confidence interval (CI) 1.02–4.86, p = 0.04], higher AUDIT scores (AOR = 1.33, 95% CI 1.25–1.42, p < 0.001), and very low prosocial behavior (AOR = 2.46, 95% CI 1.52–3.88, p < 0.001). Cigarette smoking was correlated with male sex (AOR = 9.56, 95% CI 5.64–16.62, p < 0.001), age (AOR = 1.40, 95% CI 1.14–1.75, p < 0.001), and higher CDS score (AOR = 1.17, 95% CI 1.13–1.20, p < 0.001). Conclusions: Rates of adolescent substance use were significant, with sizeable proportions reporting higher usage. This appeared to occur predominantly in specific demographics and those with a lower protective psychosocial attribute, i.e., prosocial behavior, during the lockdown. These findings should urge the strengthening of adolescent addiction care during and after the pandemic. © Copyright © 2021 Sen, Siste, Hanafi, Murtani, Christian, Limawan, Adrian and Siswidiani. |
adolescent; alcohol; cigarette; COVID-19; drugs; Indonesia |
adolescent; Alcohol Use Disorders Identification Test; Article; Cigarette Dependence Scale 12; cigarette smoking; controlled study; coronavirus disease 2019; demography; descriptive research; educational status; female; health care survey; human; Indonesia; low income country; major clinical study; male; mental disease assessment; middle income country; online analysis; pandemic; Pittsburgh Sleep Quality Index; prevalence; prosocial behavior; psychometry; sex difference; social media; social status; Strength and Difficulties Questionnaire; substance use |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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122 |
Panigoro S.S., Sutandyo N., Witjaksono F., Siregar N.C., Ramli R., Hariani R., Pangarsa E.A., Prajoko Y.W., Puruhita N., Hamdani W., Bayu D., Madjid M., Yulidar D., Fransiska J.E., Widyawati R., Tripriadi E.S., Wiwit Ade F.W., Yunda D.K., Pranata R. |
56790104300;26028099200;57070455800;6508087790;56126010900;57211658330;57204907532;56050815500;57224902090;57211471316;57193199487;57311861300;57312306100;57197735128;57312525600;57312968000;57312306200;57312748700;57201973901; |
The Association Between Triglyceride-Glucose Index as a Marker of Insulin Resistance and the Risk of Breast Cancer |
2021 |
Frontiers in Endocrinology |
12 |
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745236 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117891585&doi=10.3389%2ffendo.2021.745236&partnerID=40&md5=7c6ce4b0ece5dc9224c11aab644ae33c |
Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Surgical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Nutrition, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Surgical Oncology, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Hasanuddin University General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Nutrition, Faculty of Medicine, Wahidin Sudirohusodo General Hospital, Hasanuddin University, Makassar, Indonesia; Department of Surgical Oncology, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Department of Pathological Anatomy, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Department of Surgical Oncology, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Pathological Anatomy, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Nutrition, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Nutrition, Nutrition Cancer Reaserch Team, Dharmais Hospital National Cancer Center, Jakarta, Indonesia |
Panigoro, S.S., Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sutandyo, N., Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Witjaksono, F., Department of Nutrition, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ramli, R., Department of Surgical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Hariani, R., Department of Nutrition, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Pangarsa, E.A., Department of Hematology and Medical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Prajoko, Y.W., Department of Surgical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Puruhita, N., Department of Nutrition, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Hamdani, W., Department of Surgical Oncology, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Bayu, D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Hasanuddin University General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Madjid, M., Department of Nutrition, Faculty of Medicine, Wahidin Sudirohusodo General Hospital, Hasanuddin University, Makassar, Indonesia; Yulidar, D., Department of Surgical Oncology, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Fransiska, J.E., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Widyawati, R., Department of Pathological Anatomy, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Tripriadi, E.S., Department of Surgical Oncology, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Wiwit Ade, F.W., Department of Pathological Anatomy, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Yunda, D.K., Department of Nutrition, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Pranata, R., Department of Nutrition, Nutrition Cancer Reaserch Team, Dharmais Hospital National Cancer Center, Jakarta, Indonesia |
Background: This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index and breast cancer. Method: This is a multicenter case-control study conducted in six public referral hospitals in Indonesia. Cases are individuals aged 19 years or above who were diagnosed with breast cancer within 1 year of diagnosis, based on histopathology and immunohistochemistry. Controls were recruited from corresponding hospitals. TyG index was determined by the formula: ln (fasting TG [mg/dl] × fasting glucose [mg/dl]). Results: There were 212 participants in the breast cancer group and 212 participants in the control group. TyG index was higher in patients with breast cancer (median 8.65 [7.38, 10.9] vs. 8.30 [7.09, 10.84], p < 0.001). When compared with TyG quartile of Q1, Q4 was associated with an OR of 2.42 (1.77, 3.31), p < 0.001, Q3 was associated with an OR of 1.53 (1.21, 1.93), p < 0.001, Q2 was associated with an OR of 1.39 (1.12, 1.73), p = 0.002 for the risk of breast cancer. The dose-response relationship was nonlinear (p < 0.001). On univariate analysis, smoking (OR 2.15 [1.44, 3.22], p < 0.001), use of contraception (1.73 [1.15, 2.60], p = 0.008), alcohol consumption (OR 2.04 [0.96, 4.35], p = 0.064), and TyG Index >8.87 (OR 3.08 [1.93, 4.93], p < 0.001) were associated with risk of breast cancer. Independently associated with increased risk of breast cancer included smoking (OR 1.93 [1.23, 3.01], p = 0.004), use of contraception (OR 1.59 [1.02, 2.48], p = 0.039), and TyG Index >8.87 (OR 2.93 [1.72, 4.98], p < 0.001) Conclusion: TyG index was associated with breast cancer in a nonlinear dose-response fashion. © Copyright © 2021 Panigoro, Sutandyo, Witjaksono, Siregar, Ramli, Hariani, Pangarsa, Prajoko, Puruhita, Hamdani, Bayu, Madjid, Yulidar, Fransiska, Widyawati, Tripriadi, F. W., Yunda and Pranata. |
breast cancer; glucose; insulin; insulin resistance; triglyceride |
insulin; triacylglycerol; adult; aged; alcohol consumption; Article; breast cancer; breast feeding; case control study; contraception; controlled study; dose response; female; glucose blood level; histopathology; human; human tissue; immunohistochemistry; major clinical study; multicenter study; nutrient uptake; obesity; questionnaire; smoking; triacylglycerol blood level; underweight; univariate analysis |
Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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187 |
Utami T.W., Suwartono H., Umami E.A., Mahardika A., Surya R., Nurana L. |
57195720528;57218391609;57353182200;57352623800;56986345100;57352963000; |
Management of ovarian yolk sac tumor in pregnancy in a limited resource setting: Case report |
2021 |
Middle East Journal of Cancer |
12 |
4 |
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597 |
601 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119909750&doi=10.30476%2fmejc.2021.84039.1195&partnerID=40&md5=272b65775967af66a20f779444cac466 |
Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Utami, T.W., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suwartono, H., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Umami, E.A., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mahardika, A., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Surya, R., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nurana, L., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Ovarian yolk sac tumor in pregnancy is a very rare case (<5%). The management could be very challenging since studies regarding the disease are very limited. This case report is written in order to report a rare case of yolk sac tumor in pregnancy and its management. A 29-year-old woman with a 16 weeks gestational age (WGA) in her first pregnancy presented in the emergency room with severe lower abdominal pain. Next, she underwent exploratory laparotomy, and a biopsy was performed, which indicated an ovarian yolk sac tumor. The patient was then given neoadjuvant chemotherapy with carboplatin and paclitaxel. The pregnancy resulted in an intrauterine growth restriction (IUGR) baby, delivered on 33 WGA. The baby was delivered through C-section and the mother continued to undergo optimally debulked laparotomy, total hysterectomy, bilateral salphingo-oophorectomy, omentectomy, and rectosigmoid tumor resection. In dealing with a rare case with limited resources, tailor-made management is required. The most ideal treatment may not be performed, but the clinician should be more adaptive for the patient to have a better outcome. © 2021. |
Intrauterine growth restriction; Neoadjuvant chemotherapy; Ovarian yolk sac tumor |
bleomycin; carboplatin; cisplatin; etoposide; Ki 67 antigen; paclitaxel; abdominal pain; abdominal tenderness; adjuvant therapy; adult; Apgar score; Article; bilateral salpingo-oophorectomy; biometry; biopsy; bleeding; body mass; cancer surgery; case report; cesarean section; clinical article; echography; ectopic pregnancy; emergency ward; endometriosis; female; fetus weight; gestational age; human; human experiment; human tissue; hysterectomy; intrauterine growth retardation; laparotomy; liver metastasis; lower abdominal pain; multiple cycle treatment; neoadjuvant chemotherapy; omentectomy; physical examination; pregnancy; pregnant woman; prenatal care; salpingooophorectomy; scoring system; yolk sac tumor |
Shriaz University of Medical Sciences |
20086709 |
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Article |
Q4 |
227 |
17796 |
|
|
