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No records
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46 |
Martika W., Dilogo I.H., Setyawan R. |
57221741247;56161962800;57206249736; |
Functional outcome in scapular fracture treatment evaluation with 2-year follow-up in Cipto Mangunkusumo Hospital |
2021 |
International Journal of Surgery Open |
37 |
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100425 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119256972&doi=10.1016%2fj.ijso.2021.100425&partnerID=40&md5=b50a45ce664d7aea0b7dc9549bdde380 |
Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adult Reconstruction, Hip, and Knee Division, Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Martika, W., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dilogo, I.H., Adult Reconstruction, Hip, and Knee Division, Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyawan, R., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Standard treatment of scapular fractures is still controversial. There was no consensus for the best indication in surgical management and therapeutic choice of the scapular fracture. This study aim is to evaluate both radiological characteristics and functional outcomes between patients with scapular fracture treated with conservative and operative management. Methods: We did a case series study of 19 patients with scapular fractures between 2012 and 2017. Nine patients were treated with open reduction internal fixation and 10 patients were treated conservatively. We evaluated radiological outcome using degree of Glenopolar Angle (GPA), angulation, and medialization through anteroposterior, lateral, and scapular Y projection, functional outcome using DASH scores, and complications in 2-year follow-up. Result: The mean patient age was 46.3 ± 18.4 years in the conservative group and 42.7 ± 11.5 years in the operative group. Fracture pattern was classified using Zdravkovic and Damholt (ZD) classification. DASH Score was excellent with 9.5 ± 2.1 points in conservative group and 6.0 ± 2.5 points in operative group with insignificant difference. There was significant difference in GPA and medialization. This is supported by functional outcome of operative group which is higher compared to conservative treatment insignificantly. Conclusion: Operative treatment resulted high functional outcome and minimal complications compared to the conservative group. Operative treatment was recommended for scapular fractures that are displaced more than 9 mm and/or angulated more than 40°. Level of evidence: II, therapeutic study. © 2021 The Authors |
Conservative treatment; DASH score; Glenopolar angle; Scapular fracture; Surgical treatment; Zdravkovic and damholt classification |
adult; clinical article; clinical outcome; conservative treatment; controlled study; Disabilities of the Arm, Shoulder and Hand (score); female; follow up; functional status; human; intermethod comparison; intraoperative period; male; open reduction (procedure); orthopedic surgery; osteosynthesis; outcome assessment; preoperative evaluation; scapula fracture; Short Survey; shoulder radiography; treatment indication; x-ray computed tomography |
Elsevier Ltd |
24058572 |
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Short Survey |
Q4 |
187 |
20224 |
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53 |
Goenarjo R., Dupuy O., Fraser S., Berryman N., Perrochon A., Bosquet L. |
57192916469;55250097700;56214500000;35602918000;55628941600;6602849323; |
Cardiorespiratory fitness and prefrontal cortex oxygenation during Stroop task in older males |
2021 |
Physiology and Behavior |
242 |
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113621 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117564635&doi=10.1016%2fj.physbeh.2021.113621&partnerID=40&md5=ac7c0401817c51ece69279b94bfe1755 |
Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France; Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa (Ontario), Canada; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; Laboratoire HAVAE (EA 6310), Université de Limoges, Limoges, France; Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada; Département des Sciences de l'activité physique, Université du Québec à Montréal (UQAM), Montréal, Canada |
Goenarjo, R., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Dupuy, O., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada; Fraser, S., Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa (Ontario), Canada; Berryman, N., Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada, Département des Sciences de l'activité physique, Université du Québec à Montréal (UQAM), Montréal, Canada; Perrochon, A., Laboratoire HAVAE (EA 6310), Université de Limoges, Limoges, France; Bosquet, L., Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada, Ecole de Kinésiologie et des Sciences de l'Activité Physique (EKSAP), Faculté de Médecine, Université de Montreal, Montreal, Canada |
Aim: The aim of the current study was to assess whether executive function and prefrontal oxygenation are dependent on fitness level and age in older adults. Methods: Twenty-four healthy males aged between 55 and 69 years old were recruited for this study. They were stratified by age, leading to the creation of two groups: 55–60 years old and 61–69 years old. A median split based on CRF created higher- and lower-fit categories of participants. Cerebral oxygenation was assessed using functional near-infrared spectroscopy (fNIRS) during a computerized Stroop task. Accuracy (% of correct responses) and reaction times (ms) were used as behavioural indicators of cognitive performances. Changes in oxygenated (∆[HbO2]) and deoxygenated (∆[HHb]) hemoglobin were measured to capture neural changes. Repeated measures ANOVAs (CRF × Age × Stroop conditions) were performed to test the null hypothesis of an absence of interaction between CRF, Age and executive performance. Results: We also found an interaction between CRF and age on reaction times (p = .001), in which higher fitness levels were related to faster reaction times in the 61–69 year olds but not in the 55–60 year olds. Regarding ΔHHb, the ANOVA revealed a main effect of CRF in the right PFC (p = .04), in which higher-fit participants had a greater Δ[HHb] than the lower-fit (d = 1.5). We also found fitness by age interaction for Δ[HHb] in the right PFC (p = .04). Conclusion: Our results support the positive association of CRF on cerebral oxygenation and Stroop performance in healthy older males. They indicated that high-fit individuals performed better in the 61–69 year olds group, but not in the 55–60 years old group. We also observed a greater PFC oxygenation change (as measured by Δ[HHb]) in the high-fit individuals. © 2021 |
Cardiorespiratory fitness; Cerebral oxygenation; Older adults; Prefrontal cortex; Stroop |
hemoglobin; oxyhemoglobin; adult; age; aged; Article; blood oxygenation; brain oxygen consumption; brain radiography; cardiorespiratory fitness; controlled study; deoxygenation; executive function; functional near-infrared spectroscopy; hemoglobin blood level; human; human experiment; male; measurement accuracy; normal human; peak oxygen uptake; prefrontal cortex; reaction time; Stroop test; executive function; metabolism; middle aged; prefrontal cortex; Stroop test; Aged; Cardiorespiratory Fitness; Executive Function; Humans; Male; Middle Aged; Oxyhemoglobins; Prefrontal Cortex; Stroop Test |
Elsevier Inc. |
00319384 |
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34648819 |
Article |
Q1 |
960 |
4644 |
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57 |
Diptyanusa A., Sari I.P. |
57205340891;57197543698; |
Treatment of human intestinal cryptosporidiosis: A review of published clinical trials |
2021 |
International Journal for Parasitology: Drugs and Drug Resistance |
17 |
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128 |
138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115755098&doi=10.1016%2fj.ijpddr.2021.09.001&partnerID=40&md5=e7d5494025a277d99586bf5f73027625 |
Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia; Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
Diptyanusa, A., Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia, Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia |
The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis can result in long-term morbidity and high illness costs. The evidence of effective treatments for cryptosporidiosis has been lacking. We reviewed the published clinical trials to bring forward the feasible therapeutic options of human cryptosporidiosis in various populations and settings according to clinical improvement and parasite clearance rates. A total of 42 studies consisting of the use of nitazoxanide, paromomycin, macrolides, somatostatin analogues, letrazuril, albendazole, rifaximin, miltefosine, clofazimine, and colostrum were included in the review. The trials were mostly conducted in small number of individuals infected with human immunodeficiency virus (HIV), and there is inadequate data of controlled trials to suggest the use of these treatment modalities. Nitazoxanide was reported to be highly efficacious only in immunocompetent hosts and was found to be superior to paromomycin in the same group of patients. Macrolides showed no effective results in both clinical and parasitological improvement. Human bovine colostrum should possibly be administered as one of complementary therapeutic modalities along with other antimicrobials to reach optimal parasite eradication. Other trials of therapeutic modalities were terminated due to futility. Currently, available data is intended to aid the development of strategies for improving access to treatments in different clinical settings, as well as to help guide further studies on treatments of human intestinal cryptosporidiosis. © 2021 |
Clearance; Clinical trial; Cryptosporidiosis; Cryptosporidium; Drug; Treatment |
acetylspiramycin; albendazole; alkaline phosphatase; antiparasitic agent; azithromycin; clofazimine; erythromycin; garlicin; immunoglobulin; letrazuril; macrolide; miltefosine; nitazoxanide; octreotide; paromomycin; placebo; probiotic agent; rifaximin; roxithromycin; somatostatin derivative; spiramycin; unclassified drug; vapreotide; antiprotozoal agent; paromomycin; abdominal pain; adolescent; adult; aged; alkaline phosphatase level; alternative medicine; anorexia; antiparasitic therapy; child; cholecystitis; clinical trial (topic); colostrum; constipation; cryptosporidiosis; diarrhea; dizziness; drowsiness; drug efficacy; fatigue; fever; headache; health care access; human; Human immunodeficiency virus infection; hypertransaminasemia; infant; injection site pain; intestine obstruction; k |
Elsevier Ltd |
22113207 |
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34562754 |
Review |
Q1 |
1071 |
3953 |
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71 |
Tandaju J.R., Li W., Pateras K., Georgiopoulos G. |
57222662533;57369633600;57200224369;57188877741; |
Deriving cut-off values for continuous predictors of severe outcomes in COVID-19 through meta-analysis of individual studies |
2021 |
American Journal of Emergency Medicine |
50 |
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799 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104938971&doi=10.1016%2fj.ajem.2021.03.029&partnerID=40&md5=b4a3015c95a454387a73134ab5845aa6 |
Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom; Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athen, Greece |
Tandaju, J.R., Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; Li, W., The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Pateras, K., Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Georgiopoulos, G., School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athen, Greece |
[No abstract available] |
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clinical outcome; coronavirus disease 2019; disease severity; human; Letter; COVID-19; Humans; SARS-CoV-2 |
W.B. Saunders |
07356757 |
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33958246 |
Letter |
Q1 |
725 |
6828 |
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85 |
Wiguna T., Minayati K., Kaligis F., Ismail R.I., Wijaya E., Murtani B.J., Pradana K. |
24367785700;57218681686;36604651700;55996895500;57358945000;57216652176;57220165625; |
The Effect of Cyberbullying, Abuse, and Screen Time on Non-suicidal Self-Injury Among Adolescents During the Pandemic: A Perspective From the Mediating Role of Stress |
2021 |
Frontiers in Psychiatry |
12 |
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743329 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120410832&doi=10.3389%2ffpsyt.2021.743329&partnerID=40&md5=721d9aa51662421c0092a11d6eaf48a8 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Psychology, Universitas Tarumanegara, Jakarta, Indonesia |
Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wijaya, E., Faculty of Psychology, Universitas Tarumanegara, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pradana, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Adolescence is often a period of turmoil. The COVID-19 pandemic has increased adolescents' difficulty due to mental health consequences that may affect their developmental milestones. This study constructed and empirically tested a theoretical model of three predictive factors (cyberbullying, abuse, and screen time) and stress as the mediating factor in adolescent non-suicidal self-injury (NSSI). Structural equation model (SEM) analysis was applied to investigate stress as a mediating factor in the relationship between adolescent NSSI and cyberbullying, abuse, and screen time. This cross-sectional study used a “crowdsourcing” sample collection method to recruit 464 adolescents aged 11–17 years who were administered a questionnaire comprising scales on cyberbullying, abuse, screen time, stress, and NSSI. All scales had construct reliabilities ranging from 0.759 to 0.958. SEM statistical analysis was performed using Lisrel version 8.8 (Scientific Software International, USA) for Windows (Microsoft Corporation, Redmond, WA, USA). The mean (± SD) age of the cohort was 14.61 ± 1.65 years, and consisted of 66.7% females. Secondary high school was the highest educational background (58%). The study found that cyberbullying and abuse were direct positive predictors (critical t-value for the path > 1.96; p < 0.05) of adolescent NSSI; however, screen time did not have any direct relationship. Furthermore, stress was a significant full mediating factor of screen time and a partial mediating factor of cyberbullying and abuse in the relationship with adolescent NSSI (critical t-value of the path = 5.27; p < 0.05). Cyberbullying, screen time, and abuse with the mediating effect of stress could explain 48% of the variance in adolescent NSSI (R2 = 0.48). Adolescent mental health prevention and promotion programs need to be redesigned during the current COVID-19 pandemic to manage their stress and minimize the mental health consequences of cyberbullying, abuse, and inappropriately increased screen time. Copyright © 2021 Wiguna, Minayati, Kaligis, Ismail, Wijaya, Murtani and Pradana. |
abuse; adolescents; COVID-19; cyberbullying; Indonesia; non-suicidal self-injury; screen time; stress |
abuse; adolescent; Article; automutilation; coronavirus disease 2019; cross-sectional study; cyberbullying; educational status; female; health program; human; male; mental health; pandemic; physiological stress; prediction; questionnaire; screen time |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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88 |
Lokeswara A.W., Hiksas R., Irwinda R., Wibowo N. |
57200937543;57226152029;57205713130;15049026900; |
Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition |
2021 |
Frontiers in Cell and Developmental Biology |
9 |
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726513 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119532670&doi=10.3389%2ffcell.2021.726513&partnerID=40&md5=38456382efeb541572619e5bed470318 |
Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Lokeswara, A.W., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Preeclampsia is one of the most common obstetrical complications worldwide. The pathomechanism of this disease begins with abnormal placentation in early pregnancy, which is associated with inappropriate decidualization, vasculogenesis, angiogenesis, and spiral artery remodeling, leading to endothelial dysfunction. In these processes, appropriate cellular deaths have been proposed to play a pivotal role, including apoptosis and autophagy. The proper functioning of these physiological cell deaths for placentation depends on the wellbeing of the trophoblasts, affected by the structural and functional integrity of each cellular component including the cell membrane, mitochondria, endoplasmic reticulum, genetics, and epigenetics. This cellular wellness, which includes optimal cellular integrity and function, is heavily influenced by nutritional adequacy. In contrast, nutritional deficiencies may result in the alteration of plasma membrane, mitochondrial dysfunction, endoplasmic reticulum stress, and changes in gene expression, DNA methylation, and miRNA expression, as well as weakened defense against environmental contaminants, hence inducing a series of inappropriate cellular deaths such as abnormal apoptosis and necrosis, and autophagy dysfunction and resulting in abnormal trophoblast invasion. Despite their inherent connection, the currently available studies examined the functions of each organelle, the cellular death mechanisms and the nutrition involved, both physiologically in the placenta and in preeclampsia, separately. Therefore, this review aims to comprehensively discuss the relationship between each organelle in maintaining the physiological cell death mechanisms and the nutrition involved, and the interconnection between the disruptions in the cellular organelles and inappropriate cell death mechanisms, resulting in poor trophoblast invasion and differentiation, as seen in preeclampsia. Copyright © 2021 Lokeswara, Hiksas, Irwinda and Wibowo. |
apoptosis; autophagy; cell death; cellular wellness; nutrition; preeclampsia |
aneuploidy; cell death; cell differentiation; cell invasion; cell membrane; cell organelle; endoplasmic reticulum; endoplasmic reticulum stress; environmental factor; epigenetics; gene expression; human; mitochondrion; nonhuman; nutrition; preeclampsia; pregnancy; Review; trophoblast; vascular remodeling |
Frontiers Media S.A. |
2296634X |
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Review |
Q1 |
2452 |
946 |
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89 |
Elbarbary N.S., dos Santos T.J., de Beaufort C., Wiltshire E., Pulungan A., Scaramuzza A.E. |
35725405100;37080460700;55346159500;6603809910;57192905981;6602617288; |
The Challenges of Managing Pediatric Diabetes and Other Endocrine Disorders During the COVID-19 Pandemic: Results From an International Cross-Sectional Electronic Survey |
2021 |
Frontiers in Endocrinology |
12 |
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735554 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119406902&doi=10.3389%2ffendo.2021.735554&partnerID=40&md5=0764f19be86686d381fa20013b41f50b |
Diabetes Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Instituto Hispalense de Pediatría, Vithas Almería, Almería, Spain; Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain; Diabetes Endocrine Care Clinique Pédiatrique (DECCP), Clinique Pédiatrique/Centre Hospitalier (CH) de Luxembourg, Luxembourg; Department Pediatric Endocrinology, Free University Hospital Brussels, Brussels, Belgium; Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand; Department of Child Health, Capital and Coast District Health Board, Wellington, New Zealand; Child Health Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Diabetes and Endocrinology Nutrition, Division of Pediatrics, Azienda Socio Sanitaria Territoriale (ASST) Cremona, “Ospedale Maggiore di Cremona”, Cremona, Italy |
Elbarbary, N.S., Diabetes Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; dos Santos, T.J., Instituto Hispalense de Pediatría, Vithas Almería, Almería, Spain, Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain; de Beaufort, C., Diabetes Endocrine Care Clinique Pédiatrique (DECCP), Clinique Pédiatrique/Centre Hospitalier (CH) de Luxembourg, Luxembourg, Department Pediatric Endocrinology, Free University Hospital Brussels, Brussels, Belgium; Wiltshire, E., Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand, Department of Child Health, Capital and Coast District Health Board, Wellington, New Zealand; Pulungan, A., Child Health Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Scaramuzza, A.E., Diabetes and Endocrinology Nutrition, Division of Pediatrics, Azienda Socio Sanitaria Territoriale (ASST) Cremona, “Ospedale Maggiore di Cremona”, Cremona, Italy |
Background: Frequency, dimensions, management, and outcomes of the COVID-19 pandemic in children with endocrine disorders and diabetes were assessed. Methods: A cross-sectional electronic survey was distributed to the global network of endocrine societies. Respondents’ professional and practice profiles, clinic sizes, their country of practice, and the impact of COVID-19 on endocrine diseases were investigated. Results: Respondents from 131 pediatric endocrine centers in 51 countries across all continents completed the survey. Routine check-ups and education were altered in most pediatric endocrine clinics. Over 20% of clinics experienced a shortage of critical medications or essential supplies. ICU treatment was required for patients with diabetes and COVID-19 in 21.2% of centers. In diabetes, 44% of respondents reported increased diabetic ketoacidosis episodes in newly diagnosed cases and 30% in established cases. Biopsychosocial and behavioral changes were explicitly reported to be occurring among pediatric patients with endocrine disorders. Conclusions: This large global survey conducted during the COVID-19 pandemic highlights that diabetes is more challenging to manage than any other pediatric endocrine disorder, with an increased risk of morbidity. Psychological distress due to COVID-19 needs to be recognized and addressed. The importance of close contact with healthcare professionals should be emphasized, and medical supplies should be readily available to all patients. © Copyright © 2021 Elbarbary, dos Santos, de Beaufort, Wiltshire, Pulungan and Scaramuzza. |
adrenal; children; COVID-19; diabetes; growth; obesity and metabolic syndrome; puberty; thyroid |
anemia; anxiety; Article; behavior change; bone metabolism; child; clinical practice; coronavirus disease 2019; cross-sectional study; depression; diabetes mellitus; diabetic ketoacidosis; eating disorder; education; endocrine disease; female; gender dysphoria; genetic screening; glucose blood level; glycemic control; human; insulin dependent diabetes mellitus; insulin treatment; major clinical study; male; mental stress; metabolic syndrome X; morbidity; pandemic; pediatric patient; pharmacist; physical activity; preschool child; questionnaire; school child; suicide attempt; teleconsultation; thyroid disease |
Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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96 |
Irwinda R., Hiksas R., Lokeswara A.W., Wibowo N. |
57190855256;57226152029;57200937543;15049026900; |
Maternal and fetal characteristics to predict c-section delivery: A scoring system for pregnant women |
2021 |
Women's Health |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120494500&doi=10.1177%2f17455065211061969&partnerID=40&md5=24bd3b15eeeb46e6e6583c50495d671b |
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lokeswara, A.W., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Cesarean section is one of the most common obstetrical interventions that has been performed at an increasing rate globally, due to both medical and non-medical reasons. This study aims to develop a prediction tool for pregnant women potentially needing c-section, such that necessary preparations from the mothers, families, and health providers can be made. Methods: A total of 603 pregnant women were recruited in the first phase of c-section prediction tool development. The association between the maternal and fetal factors on the risk of c-section were analyzed, followed by a stepwise multivariate regression analysis. In the next phase, 61 pregnant women were enrolled for external validation. Discrimination was assessed using area under the curve. The calibration plot was then made and assessed using the Hosmer–Lemeshow test. Results: There were 251 (41.6%) cases of vaginal delivery and 352 (58.4%) of c-section assessed. Multivariate analysis showed that gestational age < 37 wg (OR: 1.66, 95% CI: 1.10–2.51), pre-pregnancy body mass index (underweight) (OR: 0.40, 95% CI: 0.22–0.76), no history of vaginal delivery (OR: 2.66, 95% CI: 1.76–4.02), history of uterine surgery (OR: 8.34, 95% CI: 4.54–15.30), obstetrical complications (OR: 5.61, 95% CI: 3.53–8.90), birthweight ⩾ 3500 g (OR: 4.28, 95% CI: 2.16–8.47), and non-cephalic presentation (OR: 2.74, 95% CI: 1.53–4.89) were independently associated with c-section delivery. Those parameters were included in a 7-item scoring tool, with consecutive predictive scores of 1,–1,2,3,3,2,2,1. The area under the curve result was 0.813 (95% CI: 0.779–0.847), indicating a good predictive ability. The external validation showed AUC: 0.806, 95% CI: 0.694–0.917, Hosmer–Lemeshow test p = 0.666 and calibration plot coefficient of r = 0.939. Conclusion: A total of 7 maternal-fetal factors were found to be strongly associated with c-section delivery, including gestational age < 37, maternal underweight body mass index, previous uterine surgery, obstetrical complications, birthweight ⩾ 3500, history of vaginal delivery, and non-cephalic presentation. Using these factors, a prediction tool was developed and validated with good quality. © The Author(s) 2021. |
cesarean section; maternal-fetal characteristics; mode of delivery; prediction; scoring system |
7 point scoring system; abdominal circumference; adult; area under the curve; Article; biological activity; birth weight; body mass; cesarean section; clinical examination; cohort analysis; diagnostic test accuracy study; exploratory factor analysis; female; fetus weight; forceps delivery; gestational age; human; major clinical study; maternal fetal characteristics; mortality; myomectomy; non cephalic presentation; obstetrical complication; prediction; pregnancy complication; pregnant woman; prenatal care; questionnaire; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; underweight; urologic surgery; vaginal delivery; obstetric delivery; pregnancy; Cesarean Section; Delivery, Obstetric; Female; Gestational Age; Humans; Pregnan |
SAGE Publications Ltd |
17455057 |
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34818932 |
Article |
Q1 |
1363 |
2670 |
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|
100 |
Irawati Y., Paramita C., Daniel H. |
57201260313;57219380835;57316812600; |
Challenging eyelid reconstruction in malignancies: Case reports |
2021 |
Annals of Medicine and Surgery |
71 |
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102987 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118265765&doi=10.1016%2fj.amsu.2021.102987&partnerID=40&md5=d761c9b6bbfe6b7a5a498e07f9e22253 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Paramita, C., Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Daniel, H., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Eye is one of the most crucial organs in need of protection. The most important function of eyelids is designed to protect the eyeball. Despite their small and thin surface area, they are among the most sunlight-exposed area of skins, hence, it is prone to develop eyelid tumors. As the malignant tumors have the tendency of growing aggressively and have a high mortality, we have to meticulously remove the lesion along with its surrounding tissue, if needed, to ensure the clearance of tumor margin. To strike a suitable outcome between the cosmetic and function after tumor removal is a quite challenging task. Compromise on aesthetics and eyelids’ indispensable function of protecting the eyes during management, may lead to unfavorable cosmetic deformity and loss of vision. Therefore, it is imperative that wise selection of appropriate techniques be discussed and managed accordingly. In this article, the authors reported two case scenarios of eyelid reconstruction which was performed to show the management of full-thickness defect after removal of the malignant neoplasms. Skin flaps and graft technique used to reconstruct the eyelid in each patient was different to emphasize that eyelid malignancies require an individualized management. © 2021 |
Eyelid malignancies; Eyelid reconstruction; Full-thickness defect; Skin flaps; Skin graft |
adult,human; Article; case report; clinical article; ectropion; eyelid cancer; eyelid reconstruction; female; follow up; histopathology; human; human tissue; human,clinical article; keratinocyte; lower eyelid; lymph node biopsy; middle aged; muscle graft; palpation; reconstructive surgery; sentinel lymph node biopsy; skin flap; solid mass; squamous cell carcinoma; telangiectasia; tissue flap |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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102 |
Hamid A.R.A.H., Mochtar C.A., Lisnawati, Saraswati M., Matondang S., Affan M.I.F. |
57202054669;6506558321;24449072000;57208472364;57192085914;57312341900; |
Adenocarcinoma mucinosum of extrophy bladder: A rare case report |
2021 |
International Journal of Surgery Case Reports |
88 |
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106493 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117928866&doi=10.1016%2fj.ijscr.2021.106493&partnerID=40&md5=1f53d31ce0245f1e48544663e50eb793 |
Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia |
Hamid, A.R.A.H., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Mochtar, C.A., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Lisnawati, Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Saraswati, M., Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Matondang, S., Department of Radiology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Affan, M.I.F., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Bladder exstrophy is a rare congenital anomaly while, bladder adenocarcinoma mucinous type is a rare type of bladder cancer, with aggressive behavior and inadequate response to radiation and chemotherapy. In extremely rare cases, untreated bladder exstrophy could transform into bladder mucinous adenocarcinoma. Case presentation: We report a case of a 41-year-old male with untreated bladder exstrophy that transformed into mucinous adenocarcinoma. The patient also had epispadias and a right inguinal hernia. Joint procedures were conducted to perform radical cystectomy, total penectomy and W-Pouch continent urostomy, inguinal hernia repair, osteotomy, and keystone and scrotal flap by split-thickness skin graft (STSG) for wound closure. The patient progressed well after surgery, two months after initial procedure, nephrostomies were conducted due to pouches stenosis. Due to the government's limited transportation and lockdown policy, as the Covid-19 pandemic occurred, the patient could not come to the hospital for routine follow-up and died nine-month after surgery. Clinical discussion: Bladder exstrophy is one of the risk factors of bladder cancer. Transformation of bladder exstrophy into mucinous adenocarcinoma is extremely rare, as the case is the first case to be discovered in Indonesia. Surgery, followed with a strict follow-up regime, is mainstay of treatment in this type of malignancy. Conclusion: Adenocarcinoma of mucinous type is a scarce type of bladder exstrophy malignancies. A multidiscipline approach is mandatory in these cases. Strict and regular follow up are suggested for these cases. © 2021 The Authors |
Bladder exstrophy; Epispadias; Inguinal hernia; Mucinous adenocarcinoma |
creatinine; adult; Article; bladder carcinoma; bladder exstrophy; case report; clinical article; colloid carcinoma; coronavirus disease 2019; creatinine blood level; cystectomy; echography; epispadias; excisional biopsy; hernioplasty; histopathology; human; human tissue; hydronephrosis; hydroureter; inguinal hernia; inguinal region; interstitial cystitis; lockdown; male; malignant transformation; multidisciplinary team; nephrostomy; pandemic; pelvis radiography; penis amputation; split thickness skin graft; surgical mortality; wide excision; wound closure; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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