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No records
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101 |
Lazarus G., Nelwan E.J., Hamers R.L. |
57214599425;14527452900;23034345900; |
Transaminases and serum albumin as early predictors of severe dengue |
2021 |
The Lancet Infectious Diseases |
21 |
11 |
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1488 |
1489 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117964341&doi=10.1016%2fS1473-3099%2821%2900583-1&partnerID=40&md5=4f1ea8000ad6ebe270b36045aad4f5b7 |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, United Kingdom |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Nelwan, E.J., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamers, R.L., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, United Kingdom |
[No abstract available] |
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aminotransferase; serum albumin; aminotransferase; serum albumin; human; Letter; meta analysis; protein blood level; severe dengue; systematic review (topic); dengue; liver function test; severe dengue; Dengue; Humans; Liver Function Tests; Serum Albumin; Severe Dengue; Transaminases |
Elsevier Ltd |
14733099 |
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34717802 |
Letter |
Q1 |
7475 |
144 |
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105 |
Akmal M.M., Pabittei D.R., Prapassaro T., Suhartono R., Moll F.L., van Herwaarden J.A. |
57212520722;36722034600;57205214358;57218884615;7103009095;6602663510; |
A systematic review of the current status of interventions for type II endoleak after EVAR for abdominal aortic aneurysms |
2021 |
International Journal of Surgery |
95 |
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106138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117194344&doi=10.1016%2fj.ijsu.2021.106138&partnerID=40&md5=04d622b377ba196029ff5e68c6be3e4c |
Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands; Vascular surgery Division, Departement of Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Indonesia; Departement of Physiology, Hasanudin University, Indonesia; Departement of vascular surgery, Siriraj Hospital, Mahidol UniversityBangkok, Thailand |
Akmal, M.M., Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands, Vascular surgery Division, Departement of Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Indonesia; Pabittei, D.R., Departement of Physiology, Hasanudin University, Indonesia; Prapassaro, T., Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands, Departement of vascular surgery, Siriraj Hospital, Mahidol UniversityBangkok, Thailand; Suhartono, R., Vascular surgery Division, Departement of Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Indonesia; Moll, F.L., Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands; van Herwaarden, J.A., Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands |
Objective: To study the mid- and long-term outcomes of type II endoleak treatment after EVAR and the technical aspects of different techniques to exclude endoleaks which different embolic agents. Methods: A systematic review was performed using the approach recommended by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for meta-analyses of interventional studies. The comprehensive search was conducted using the following database: MEDLINE, EMBASE, and the Cochrane Library. Patient characteristic, intervention approaches, embolic agents, and results at mid and long term follow up were studied. Results: A total of 6 studies corresponding to a total of 141 patients fulfilled the inclusion criteria with a mean age of 73–78.6 years and a mean duration of follow up varying from 25 to 42 months. There were different techniques for embolization used (translumbar, transarterial, and transcaval approach) with various types of embolic agents. In all studies, the indication for embolization of the type II endoleaks was sac enlargement of more than 5 mm. A wide range of technical success rate was reported regardless of the intervention strategy being used (17,6%–100%). The overall technical success rate of all studies was 62%. Conclusion: This systematic review shows that there is a wide variety of techniques to exclude a persistent type II endoleak. Different kinds of embolic agents have be used. Due to a lack of peer reviewed data on longterm follow-up, it was not possible to come to recommendations what treatment would be the best for a durable exclusion of a persistent type II endoleak after an initially successful EVAR. There remains an urgent need for proper executed studies, either randomized or with close observation in relation to longer follow-up. © 2021 The Authors |
Abdominal aorta aneurysm; Aneurysm repair; Endoleaks; Endovascular aneurysm repair; Type |
ethylene vinyl alcohol copolymer; glue; iodinated poppyseed oil; onyx copolymer; thrombin; abdominal aortic aneurysm; aged; artificial embolization; clinical outcome; cohort analysis; conservative treatment; data extraction; endoleak; endovascular aneurysm repair; follow up; human; laparoscopic surgery; major clinical study; meta analysis; outcome assessment; postoperative infection; practice guideline; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; quality control; Review; selective transcaval embolization; surgical approach; systematic review; transarterial embolization; translumbar embolization; treatment duration; treatment indication; type ii endoleak; very elderly; adverse event; artificial embolization; endoleak; endovascular surgery; Aged; Aortic Aneurysm, Abdo |
Elsevier Ltd |
17439191 |
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34637951 |
Review |
Q1 |
1315 |
2831 |
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112 |
Ong J., Ong A.M.L., Ong S., Xin X., Lee Y.Y., Pausawasdi N., De Lusong M.A., Makmun D., Chong V.H., Ho S.H., Lim W., Ong D., Dan Y.Y., Khor C. |
57193716100;36942342000;35741447900;57326122500;56191149300;6602327609;23767987600;16638046900;54790563600;50561284200;57194415809;56013316700;8699022400;8549610200; |
The impact of the coronavirus disease 2019 pandemic on gastroenterologists in Southeast Asia: A mixed-methods study |
2021 |
Journal of Gastroenterology and Hepatology (Australia) |
36 |
11 |
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3056 |
3068 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112680822&doi=10.1111%2fjgh.15594&partnerID=40&md5=3c1bb0505aa3a502aa7cea4abadd518a |
Department of Medicine, National University of Singapore, Singapore; Department of Engineering, University of Cambridge, Cambridge, United Kingdom; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore; Department of Surgical Intensive Care, Singapore General Hospital, Singapore; Department of Anaesthesiology, Sengkang General Hospital, Singapore; Health Services Research Unit, Singapore General Hospital, Singapore; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia; GI Function and Motility Unit, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia; Division of Gastroenterology, Department of Medicine, Mahidol University Faculty of Medicine at Siriraj Hospital, Bangkok, Thailand; Section of Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Philippine General Hospital, Manila, Philippines; Faculty of Medicine, Division of Gastroenterology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Gastroenterology Unit, Department of Medicine, RIPAS Hospital, Bandar Seri Begawan, Brunei Darussalam; Institute of Health Sciences, PAPRSB Universiti of Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam; Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Anaesthesiology, Singapore General Hospital, Singapore; Department of Medicine, Division of Gastroenterology and Hepatology, National University Hospital, Singapore |
Ong, J., Department of Medicine, National University of Singapore, Singapore, Department of Engineering, University of Cambridge, Cambridge, United Kingdom; Ong, A.M.L., Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Duke-NUS Medical School, Singapore; Ong, S., Department of Surgical Intensive Care, Singapore General Hospital, Singapore, Department of Anaesthesiology, Sengkang General Hospital, Singapore; Xin, X., Health Services Research Unit, Singapore General Hospital, Singapore; Lee, Y.Y., School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia, GI Function and Motility Unit, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia; Pausawasdi, N., Division of Gastroenterology, Department of Medicine, Mahidol University Faculty of Medicine at Siriraj Hospital, Bangkok, Thailand; De Lusong, M.A., Section of Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Philippine General Hospital, Manila, Philippines; Makmun, D., Faculty of Medicine, Division of Gastroenterology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Chong, V.H., Gastroenterology Unit, Department of Medicine, RIPAS Hospital, Bandar Seri Begawan, Brunei Darussalam, Institute of Health Sciences, PAPRSB Universiti of Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam; Ho, S.H., Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Lim, W., Department of Anaesthesiology, Sengkang General Hospital, Singapore, Department of Anaesthesiology, Singapore General Hospital, Singapore; Ong, D., Department of Medicine, Division of Gastroenterology and Hepatology, National University Hospital, Singapore; Dan, Y.Y., Department of Medicine, National University of Singapore, Singapore, Department of Medicine, Division of Gastroenterology and Hepatology, National University Hospital, Singapore; Khor, C., Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Duke-NUS Medical School, Singapore |
Background and Aim: The coronavirus disease 2019 pandemic has impacted gastroenterology practices worldwide; however, its protracted effects within Southeast Asia were unknown. The primary aim of the study was to determine the impact of the pandemic on clinical demands including burnout among gastroenterologists within the region. The secondary aim was to identify risk factors for burnout and determine regional stressors. Methods: This was a mixed-methods study. Gastroenterologists were surveyed electronically between September 1 and December 7, 2020, via gastroenterology and endoscopy societies of Brunei, Indonesia, Malaysia, Philippines, Singapore, and Thailand. Quantitative and qualitative data were collected. The 22-item Maslach Burnout Inventory-Human Services Survey (MBI-HSS) was used to detect burnout. Quantitative data were non-parametric; non-parametric methods were used for statistical comparisons. Logistic regression was used to determine risk factors for burnout. Content analysis method was used to analyze qualitative data. Ethical approval was obtained. Results: A total of 73.0% reported that they were still significantly affected by the pandemic. Of these, 40.5% reported increased workload and 59.5% decreased workload. Statistically significant differences in weekly working hours, endoscopy, and inpatient volumes were present. No differences were observed in outpatient volumes, likely because of telemedicine. Burnout was common; however, 50.1% of gastroenterologists were unaware of or did not have access to mental health support. This, as well as depression, being a trainee, and public sector work, increased burnout risk significantly. Conclusion: The effects of the pandemic are multifaceted, and burnout is common among Southeast Asian gastroenterologists. Safeguards for mental health are suboptimal, and improvements are urgently needed. © 2021 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
burnout; COVID-19; gastroenterologists; gastroenterology; pandemic |
adult; Article; Brunei Darussalam; content analysis; controlled study; coronavirus disease 2019; data collection method; depression; endoscopy; female; gastroenterologist; hospital patient; human; Indonesia; job stress; logistic regression analysis; major clinical study; Malaysia; male; Maslach Burnout Inventory-Human Services Survey; mental health; multicenter study; nonparametric test; pandemic; Philippines; professional burnout; public sector; qualitative research; quantitative analysis; risk factor; Singapore; Southeast Asia; telemedicine; Thailand; workload; burnout; epidemiology; gastroenterologist; middle aged; pandemic; psychology; questionnaire; Adult; Asia, Southeastern; Burnout, Professional; COVID-19; Female; Gastroenterologists; Humans; Male; Middle Aged; Pandemics; SARS-CoV-2 |
John Wiley and Sons Inc |
08159319 |
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34159640 |
Article |
Q1 |
1214 |
3242 |
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118 |
Sen L.T., Siste K., Hanafi E., Murtani B.J., Christian H., Limawan A.P., Adrian, Siswidiani L.P. |
57219034101;55644113100;56737010600;57216652176;57209266195;57202712511;57216932703;57219029296; |
Insights Into Adolescents' Substance Use in a Low–Middle-Income Country During the COVID-19 Pandemic |
2021 |
Frontiers in Psychiatry |
12 |
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739698 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118257704&doi=10.3389%2ffpsyt.2021.739698&partnerID=40&md5=9b8aba71c0b6aaab6c7e81012e3c8927 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: The COVID-19 pandemic and its lockdown have been a significant life event for many individuals, particularly adolescents. The immense psychological pressure could drive risky behavior, e.g., substance use, while lockdown might lead to decreased use. This study aimed to observe the change in substance use among adolescents in Indonesia and the moderating variables to consumption during the COVID-19 lockdown period. Methods: This study utilized an online survey from April 28, 2020 to June 30, 2020. The hyperlink was disseminated to school administrators and parenting groups through social media and direct messages. A total of 2,932 adolescents (17.4 ± 2.24 and 78.7% females) submitted valid responses. The survey was comprised of a sociodemographic section, substance use details, and psychometric sections, including the Alcohol Use Disorders Identification Test (AUDIT), Cigarette Dependence Scale 12 (CDS-12), Pittsburgh Sleep Quality Index (PSQI), and Strength and Difficulties Questionnaire (SDQ). Results: Overall, adolescent alcohol use during the pandemic was 5.1%, cigarette smoking was 3.1%, and drug consumption was 0.4%. Over half (53.4%) of alcohol drinkers reported increased drinking, and 33.1% had harmful or dependence-like drinking behavior; in contrast, 44.4% of adolescent smokers disclosed reduced cigarette consumption. Around 37.8% of the drug users indicated increased use. During the pandemic, adolescent alcohol use was associated with higher education [adjusted odds ratio (AOR) = 2.67, 95% confidence interval (CI) 1.02–4.86, p = 0.04], higher AUDIT scores (AOR = 1.33, 95% CI 1.25–1.42, p < 0.001), and very low prosocial behavior (AOR = 2.46, 95% CI 1.52–3.88, p < 0.001). Cigarette smoking was correlated with male sex (AOR = 9.56, 95% CI 5.64–16.62, p < 0.001), age (AOR = 1.40, 95% CI 1.14–1.75, p < 0.001), and higher CDS score (AOR = 1.17, 95% CI 1.13–1.20, p < 0.001). Conclusions: Rates of adolescent substance use were significant, with sizeable proportions reporting higher usage. This appeared to occur predominantly in specific demographics and those with a lower protective psychosocial attribute, i.e., prosocial behavior, during the lockdown. These findings should urge the strengthening of adolescent addiction care during and after the pandemic. © Copyright © 2021 Sen, Siste, Hanafi, Murtani, Christian, Limawan, Adrian and Siswidiani. |
adolescent; alcohol; cigarette; COVID-19; drugs; Indonesia |
adolescent; Alcohol Use Disorders Identification Test; Article; Cigarette Dependence Scale 12; cigarette smoking; controlled study; coronavirus disease 2019; demography; descriptive research; educational status; female; health care survey; human; Indonesia; low income country; major clinical study; male; mental disease assessment; middle income country; online analysis; pandemic; Pittsburgh Sleep Quality Index; prevalence; prosocial behavior; psychometry; sex difference; social media; social status; Strength and Difficulties Questionnaire; substance use |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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122 |
Panigoro S.S., Sutandyo N., Witjaksono F., Siregar N.C., Ramli R., Hariani R., Pangarsa E.A., Prajoko Y.W., Puruhita N., Hamdani W., Bayu D., Madjid M., Yulidar D., Fransiska J.E., Widyawati R., Tripriadi E.S., Wiwit Ade F.W., Yunda D.K., Pranata R. |
56790104300;26028099200;57070455800;6508087790;56126010900;57211658330;57204907532;56050815500;57224902090;57211471316;57193199487;57311861300;57312306100;57197735128;57312525600;57312968000;57312306200;57312748700;57201973901; |
The Association Between Triglyceride-Glucose Index as a Marker of Insulin Resistance and the Risk of Breast Cancer |
2021 |
Frontiers in Endocrinology |
12 |
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745236 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117891585&doi=10.3389%2ffendo.2021.745236&partnerID=40&md5=7c6ce4b0ece5dc9224c11aab644ae33c |
Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Surgical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Nutrition, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Surgical Oncology, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Hasanuddin University General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Nutrition, Faculty of Medicine, Wahidin Sudirohusodo General Hospital, Hasanuddin University, Makassar, Indonesia; Department of Surgical Oncology, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Department of Pathological Anatomy, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Department of Surgical Oncology, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Pathological Anatomy, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Nutrition, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Nutrition, Nutrition Cancer Reaserch Team, Dharmais Hospital National Cancer Center, Jakarta, Indonesia |
Panigoro, S.S., Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sutandyo, N., Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Witjaksono, F., Department of Nutrition, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ramli, R., Department of Surgical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Hariani, R., Department of Nutrition, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Pangarsa, E.A., Department of Hematology and Medical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Prajoko, Y.W., Department of Surgical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Puruhita, N., Department of Nutrition, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Hamdani, W., Department of Surgical Oncology, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Bayu, D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Hasanuddin University General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Madjid, M., Department of Nutrition, Faculty of Medicine, Wahidin Sudirohusodo General Hospital, Hasanuddin University, Makassar, Indonesia; Yulidar, D., Department of Surgical Oncology, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Fransiska, J.E., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Widyawati, R., Department of Pathological Anatomy, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Tripriadi, E.S., Department of Surgical Oncology, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Wiwit Ade, F.W., Department of Pathological Anatomy, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Yunda, D.K., Department of Nutrition, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Pranata, R., Department of Nutrition, Nutrition Cancer Reaserch Team, Dharmais Hospital National Cancer Center, Jakarta, Indonesia |
Background: This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index and breast cancer. Method: This is a multicenter case-control study conducted in six public referral hospitals in Indonesia. Cases are individuals aged 19 years or above who were diagnosed with breast cancer within 1 year of diagnosis, based on histopathology and immunohistochemistry. Controls were recruited from corresponding hospitals. TyG index was determined by the formula: ln (fasting TG [mg/dl] × fasting glucose [mg/dl]). Results: There were 212 participants in the breast cancer group and 212 participants in the control group. TyG index was higher in patients with breast cancer (median 8.65 [7.38, 10.9] vs. 8.30 [7.09, 10.84], p < 0.001). When compared with TyG quartile of Q1, Q4 was associated with an OR of 2.42 (1.77, 3.31), p < 0.001, Q3 was associated with an OR of 1.53 (1.21, 1.93), p < 0.001, Q2 was associated with an OR of 1.39 (1.12, 1.73), p = 0.002 for the risk of breast cancer. The dose-response relationship was nonlinear (p < 0.001). On univariate analysis, smoking (OR 2.15 [1.44, 3.22], p < 0.001), use of contraception (1.73 [1.15, 2.60], p = 0.008), alcohol consumption (OR 2.04 [0.96, 4.35], p = 0.064), and TyG Index >8.87 (OR 3.08 [1.93, 4.93], p < 0.001) were associated with risk of breast cancer. Independently associated with increased risk of breast cancer included smoking (OR 1.93 [1.23, 3.01], p = 0.004), use of contraception (OR 1.59 [1.02, 2.48], p = 0.039), and TyG Index >8.87 (OR 2.93 [1.72, 4.98], p < 0.001) Conclusion: TyG index was associated with breast cancer in a nonlinear dose-response fashion. © Copyright © 2021 Panigoro, Sutandyo, Witjaksono, Siregar, Ramli, Hariani, Pangarsa, Prajoko, Puruhita, Hamdani, Bayu, Madjid, Yulidar, Fransiska, Widyawati, Tripriadi, F. W., Yunda and Pranata. |
breast cancer; glucose; insulin; insulin resistance; triglyceride |
insulin; triacylglycerol; adult; aged; alcohol consumption; Article; breast cancer; breast feeding; case control study; contraception; controlled study; dose response; female; glucose blood level; histopathology; human; human tissue; immunohistochemistry; major clinical study; multicenter study; nutrient uptake; obesity; questionnaire; smoking; triacylglycerol blood level; underweight; univariate analysis |
Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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124 |
Bartlett A.W., Sudjaritruk T., Mohamed T.J., Anugulruengkit S., Kumarasamy N., Phongsamart W., Ly P.S., Truong K.H., Van Nguyen L., Do V.C., Ounchanum P., Puthanakit T., Chokephaibulkit K., Lumbiganon P., Kurniati N., Nik Yusoff N.K., Wati D.K., Sohn A.H., Kariminia A. |
56511395900;36538198800;46961185600;57209773680;7003549856;8885235300;9743902800;35811540200;54396225800;56732729400;57200558813;8071686900;7003974471;35564244800;36473260300;6504631866;55816676300;7006405275;6602745222; |
Identification, Management, and Outcomes of Combination Antiretroviral Treatment Failure in Adolescents With Perinatal Human Immunodeficiency Virus Infection in Asia |
2021 |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
73 |
7 |
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e1919 |
e1926 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118283335&doi=10.1093%2fcid%2fciaa872&partnerID=40&md5=7af8cf47bd95718a30d3277b5797f9ba |
Kirby Institute, University of New South Wales, Sydney, Australia; Department of Pediatrics, Faculty of Medicine, Research Institute for Health Sciences, Chiang Mai UniversityChiang Mai, Thailand; Women and Children Hospital Kuala LumpurKuala Lumpur, Malaysia; Department of Pediatrics, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand; Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand; Chennai Antiviral Research and Treatment Clinical Research Site, VHS-Infectious Diseases Medical Centre, Voluntary Health Services, Chennai, India; Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand; National Centre for HIV/AIDS, Dermatology and Sexually Transmitted DiseasesPhnom Penh, Cambodia; Children's Hospital 1, Ho Chi Minh City, Viet Nam; National Hospital of PediatricsHanoi, Viet Nam; Children's Hospital 2, Ho Chi Minh City, Viet Nam; Chiangrai Prachanukroh HospitalChiang Rai, Thailand; Department of Pediatrics, Faculty of Medicine, Khon Kaen UniversityKhon Kaen, Thailand; Cipto Mangunkusumo-Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Hospital Raja Perempuan Zainab IIKelantan, Malaysia; Sanglah Hospital, Udayana UniversityBali, Indonesia; TREAT Asia, amfAR-the Foundation for AIDS ResearchBangkok, Thailand |
Bartlett, A.W., Kirby Institute, University of New South Wales, Sydney, Australia; Sudjaritruk, T., Department of Pediatrics, Faculty of Medicine, Research Institute for Health Sciences, Chiang Mai UniversityChiang Mai, Thailand; Mohamed, T.J., Women and Children Hospital Kuala LumpurKuala Lumpur, Malaysia; Anugulruengkit, S., Department of Pediatrics, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site, VHS-Infectious Diseases Medical Centre, Voluntary Health Services, Chennai, India; Phongsamart, W., Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand; Ly, P.S., National Centre for HIV/AIDS, Dermatology and Sexually Transmitted DiseasesPhnom Penh, Cambodia; Truong, K.H., Children's Hospital 1, Ho Chi Minh City, Viet Nam; Van Nguyen, L., National Hospital of PediatricsHanoi, Viet Nam; Do, V.C., Children's Hospital 2, Ho Chi Minh City, Viet Nam; Ounchanum, P., Chiangrai Prachanukroh HospitalChiang Rai, Thailand; Puthanakit, T., Department of Pediatrics, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand; Chokephaibulkit, K., Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand; Lumbiganon, P., Department of Pediatrics, Faculty of Medicine, Khon Kaen UniversityKhon Kaen, Thailand; Kurniati, N., Cipto Mangunkusumo-Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Nik Yusoff, N.K., Hospital Raja Perempuan Zainab IIKelantan, Malaysia; Wati, D.K., Sanglah Hospital, Udayana UniversityBali, Indonesia; Sohn, A.H., TREAT Asia, amfAR-the Foundation for AIDS ResearchBangkok, Thailand; Kariminia, A., Kirby Institute, University of New South Wales, Sydney, Australia |
BACKGROUND: Combination antiretroviral therapy (cART) failure is a major threat to human immunodeficiency virus (HIV) programs, with implications for individual- and population-level outcomes. Adolescents with perinatally acquired HIV infection (PHIVA) should be a focus for treatment failure given their poorer outcomes compared to children and adults. METHODS: Data (2014-2018) from a regional cohort of Asian PHIVA who received at least 6 months of continuous cART were analyzed. Treatment failure was defined according to World Health Organization criteria. Descriptive analyses were used to report treatment failure and subsequent management and evaluate postfailure CD4 count and viral load trends. Kaplan-Meier survival analyses were used to compare the cumulative incidence of death and loss to follow-up (LTFU) by treatment failure status. RESULTS: A total 3196 PHIVA were included in the analysis with a median follow-up period of 3.0 years, of whom 230 (7.2%) had experienced 292 treatment failure events (161 virologic, 128 immunologic, 11 clinical) at a rate of 3.78 per 100 person-years. Of the 292 treatment failure events, 31 (10.6%) had a subsequent cART switch within 6 months, which resulted in better immunologic and virologic outcomes compared to those who did not switch cART. The 5-year cumulative incidence of death and LTFU following treatment failure was 18.5% compared to 10.1% without treatment failure. CONCLUSIONS: Improved implementation of virologic monitoring is required to realize the benefits of virologic determination of cART failure. There is a need to address issues related to accessibility to subsequent cART regimens, poor adherence limiting scope to switch regimens, and the role of antiretroviral resistance testing. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. |
adolescent; antiretroviral therapy; HIV; treatment failure |
anti human immunodeficiency virus agent; adolescent; adult; Asia; CD4 lymphocyte count; child; female; human; Human immunodeficiency virus infection; pregnancy; treatment failure; virus load; Adolescent; Adult; Anti-HIV Agents; Asia; CD4 Lymphocyte Count; Child; Female; HIV Infections; Humans; Pregnancy; Treatment Failure; Viral Load |
NLM (Medline) |
15376591 |
|
32589711 |
Article |
Q1 |
3440 |
518 |
|
|
|
140 |
Waters S., Agostino M., Lee S., Ariyanto I., Kresoje N., Leary S., Munyard K., Gaudieri S., Gaff J., Irish A., Keil A.D., Price P., Allcock R.J.N. |
57195514207;34771068500;56272877300;57193538110;55413004800;56906725500;6506851062;56245970200;57193534280;7004314741;57339623900;57201814264;7003764659; |
Sequencing directly from clinical specimens reveals genetic variations in HCMV-encoded chemokine receptor us28 that may influence antibody levels and interactions with human chemokines |
2021 |
Microbiology Spectrum |
9 |
2 |
e00020-21 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119150219&doi=10.1128%2fSpectrum.00020-21&partnerID=40&md5=d943d30d66f9a7de80628f87fcbb3810 |
Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia; Curtin Institute for Computation, Curtin University, Bentley, WA, Australia; Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA, Australia; Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia; School of Human Sciences, University of Western Australia, Perth, WA, Australia; Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States; Department of Nephrology, Fiona Stanley Hospital, Murdoch, WA, Australia; Department of Diagnostic Genomics, PathWest Laboratory Medicine WA, Nedlands, WA, Australia |
Waters, S., Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia; Agostino, M., Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia, Curtin Institute for Computation, Curtin University, Bentley, WA, Australia; Lee, S., Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia, Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA, Australia; Ariyanto, I., Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kresoje, N., School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia; Leary, S., Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia; Munyard, K., Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia; Gaudieri, S., Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia, School of Human Sciences, University of Western Australia, Perth, WA, Australia, Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States; Gaff, J., Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia; Irish, A., Department of Nephrology, Fiona Stanley Hospital, Murdoch, WA, Australia; Keil, A.D., Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA, Australia; Price, P., Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia; Allcock, R.J.N., School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia, Department of Diagnostic Genomics, PathWest Laboratory Medicine WA, Nedlands, WA, Australia |
Human cytomegalovirus (HCMV) is a beta-herpesvirus carried by;80% of the world’s population. Acute infections are asymptomatic in healthy individuals but generate diverse syndromes in neonates, solid organ transplant recipients, and HIV-infected individuals. The HCMV gene US28 encodes a homolog of a human chemokine receptor that is able to bind several chemokines and HIV gp120. Deep sequencing technologies were used to sequence US28 directly from 60 clinical samples from Indonesian HIV patients and Australian renal transplant recipients, healthy adults, and neonates. Molecular modeling approaches were used to predict whether nine nonsynonymous mutations in US28 may alter protein binding to a panel of six chemokines and two variants of HIV gp120. Ninety-two percent of samples contained more than one variant of HCMV, as defined by at least one nonsynonymous mutation. Carriage of these variants differed between neonates and adults, Australian and Indonesian samples, and saliva samples and blood leukocytes. Two nonsynonymous mutations (N170D and R267K) were associated with increased levels of immediate early protein 1 (IE-1) and glycoprotein B (gB) HCMV-reactive antibodies, suggesting a higher viral burden. Seven of the nine mutations were predicted to alter binding of at least one ligand. Overall, HCMV variants are common in all populations and have the potential to affect US28 interactions with human chemokines and/or gp120 and alter responses to the virus. The findings relied on deep sequencing technologies applied directly to clinical samples, so the variants exist in vivo. IMPORTANCE Human cytomegalovirus (HCMV) is a common viral pathogen of solid organ transplant recipients, neonates, and HIV-infected individuals. HCMV encodes homologs of several host genes with the potential to influence viral persistence and/ or pathogenesis. Here, we present deep sequencing of an HCMV chemokine receptor homolog, US28, acquired directly from clinical specimens. Carriage of these variants differed between patient groups and was associated with different levels of circulating HCMV-reactive antibodies. These features are consistent with a role for US28 in HCMV persistence and pathogenesis. This was supported by in silico analyses of the variant sequences demonstrating altered ligand-binding profiles. The data delineate a novel approach to understanding the pathogenesis of HCMV and may impact the development of an effective vaccine. Copyright © 2021 Waters et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Chemokine receptor; Deep sequencing; HIV patients; Human cytomegalovirus; Renal transplant recipients; US28 |
arginine; asparagine; aspartic acid; chemokine; chemokine receptor; chemokine receptor US28; glycoprotein B; glycoprotein gp 120; immediate early protein; immediate early protein 1; lysine; unclassified drug; virus antibody; chemokine; chemokine receptor; protein binding; US28 receptor, Cytomegalovirus; viral protein; virus antibody; adult; Article; Australian; blood; controlled study; genetic variation; graft recipient; human; Human cytomegalovirus; Human immunodeficiency virus infection; Indonesian; kidney transplantation; leukocyte; molecular model; mutation; newborn; nonhuman; protein protein interaction; saliva; virus load; amino acid sequence; blood; Cytomegalovirus; cytomegalovirus infection; genetic variation; genetics; high throughput sequencing; immunology; infant; isolation and |
American Society for Microbiology |
21650497 |
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34704798 |
Article |
Q1 |
2502 |
907 |
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144 |
Susiloretni K.A., Smith E.R., Suparmi, Marsum, Agustina R., Shankar A.H. |
55920057100;55479658700;57201388096;57203690495;57214141404;7005442634; |
The psychological distress of parents is associated with reduced linear growth of children: Evidence from a nationwide population survey |
2021 |
PLoS ONE |
16 |
10 October |
e0246725 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118229642&doi=10.1371%2fjournal.pone.0246725&partnerID=40&md5=e63e172d790e5a4d43ab7ba273dd42d6 |
Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Department of Global Health, George Washington University, Washington, D.C., United States; National Health Institute Research and Development, Jakarta, Indonesia; Faculty of Medicine, Department of Nutrition, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Nuffield Department of Medicine, The Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom |
Susiloretni, K.A., Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Smith, E.R., Department of Global Health, George Washington University, Washington, D.C., United States; Suparmi, National Health Institute Research and Development, Jakarta, Indonesia; Marsum, Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Agustina, R., Faculty of Medicine, Department of Nutrition, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Shankar, A.H., Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Nuffield Department of Medicine, The Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom |
Background Stunting, an indicator of restricted linear growth, has become a primary measure of childhood undernutrition due to its persistent high prevalence globally, and importance for health and development. Although the etiology is recognized as complex, most analyses have focused on social and biomedical determinants, with limited attention on psychological factors affecting care and nurturing in the home. We assessed whether the psychological distress of parents is related to child linear growth and stunting, and documented the associated risk factors, and examined the relationship between parental distress and behavioral and other risk factors for stunting. Methods We used data from the Indonesia National Health Survey 2013, including 46,315 children 6–59 months of age. Multivariate linear, logistic, and multilevel multinomial logistic regression, using survey weights, were used to assess the relationship between parental distress, as assessed by the WHO Self Reporting Questionnaire (SRQ20), with height-for-age z score (HAZ), stunting, and behavioral and other risk factors for stunting. Results Maternal, paternal and parental distress (i.e. both maternal and paternal distress) were associated with reduced linear growth of the children by 0.086 (95% CI -0.17, -0.00), 0.11 (95% CI -0.24, -0.02) and 0.19 (95% CI -0.37, -0.00) HAZ-scores, respectively. Maternal and paternal distress increased the risk of mild stunting (HAZ <-1) by 33% (95% CI 1.17,1.50) and 37% (95% CI 1.18,1.60), and the risk of moderate stunting (HAZ <-2) by 25% (95% CI 1.10,1.43) and 28% (95% CI 1.08,1.51]), respectively. Parental stress increased the risk of moderate stunting by 40% (95% CI 1.06,1.85). Amongst specific groups of risk factors, the proportion of HAZ-score lost was associated with socioeconomic factors (30.3%) including, low wealth, low maternal occupational status, low maternal education, rural residence, and low paternal occupational status; physiological factors (15.5%) including low maternal height, low maternal mid-upper arm circumference, being male, low paternal height; behavioral factors (8.9%) including open garbage disposal, paternal smoking, not using iodized salt; and experiencing at least one infectious diseases episode (1.1%). Conclusions Maternal, paternal and parental stress were associated with reduced linear growth of children. These findings highlight the complex etiology of stunting and suggest nutritional and other biomedical interventions are insufficient, and that promotion of mental and behavioral health programs for parents must be pursued as part of a comprehensive strategy to enhance child growth and development, i.e. improved caretaker capacity, integrated community development, improved parenting skills, as well as reduced gender discrimination, and domestic violence. © 2021 Susiloretni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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sodium chloride; adult; anthropometric parameters; arm circumference; Article; body height; child; child development; child growth; child parent relation; distress syndrome; domestic violence; education; female; health behavior; health program; health survey; height for age z score; human; Indonesia; infant; infection; male; maternal stress; multivariate logistic regression analysis; occupation; parental stress; paternal smoking; paternal stress; physiology; population; risk factor; rural area; Self Reporting Questionnaire 20; sex ratio; sexism; socioeconomics; stunting; waste disposal; wealth distribution; cross-sectional study; distress syndrome; educational status; growth disorder; nutritional status; physiology; preschool child; prevalence; psychology; rural population; Body Height; Ch |
Public Library of Science |
19326203 |
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34699530 |
Article |
Q1 |
990 |
4434 |
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147 |
Merati T.P., Karyana M., Tjitra E., Kosasih H., Aman A.T., Alisjahbana B., Lokida D., Arlinda D., Maldarelli F., Neal A., Arif M., Gasem M.H., Lukman N., Sudarmono P., Lau C.-Y., Hadi U., Lisdawati V., Wulan W.N., Lane H.C., Siddiqui S. |
57203678680;24449083500;57204151009;6507043017;6701594071;6506944516;57190663838;57218444330;57210198407;57220466230;56740206600;6508371601;57190737414;6507855437;16245242000;55804160500;56786334300;57204491118;57197596240;8707129300; |
Prevalence of HIV infection and resistance mutations in patients hospitalized for febrile illness in Indonesia |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
4 |
|
960 |
965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117017901&doi=10.4269%2fajtmh.20-1595&partnerID=40&md5=f52639e32eebbadb71cd505b119b26d4 |
Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia; Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia; National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia; Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia; Indonesia Research Partnership on Infections Disease, Jalan Percetakan Negara No. 29, Jakarta, 10560, Indonesia |
Merati, T.P., Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Karyana, M., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia, Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Tjitra, E., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia; Kosasih, H., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia, Indonesia Research Partnership on Infections Disease, Jalan Percetakan Negara No. 29, Jakarta, 10560, Indonesia; Aman, A.T., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Alisjahbana, B., Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Lokida, D., Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia; Arlinda, D., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia, Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Maldarelli, F., National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Neal, A., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Arif, M., Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia; Gasem, M.H., Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Lukman, N., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Sudarmono, P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lau, C.-Y., National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Hadi, U., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Lisdawati, V., Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia; Wulan, W.N., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Lane, H.C., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Siddiqui, S., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States |
HIV prevalence in Indonesia is increasing, and only 64% of infected individuals know their status. In a prospective cohort of 1,453 hospitalized patients with unexplained fever, 46 (3.2%) had HIV, including 15 (1.1%) patients without a prior HIV diagnosis. Among 31 subjects previously known to have HIV, 21 (68%) had been receiving combination antiretroviral therapy (cART) at the time of enrollment. Of 39 HIV cases with HIV RNA levels $ 100 copies/mL, sequencing for genotype analysis and resistance testing was successful in 30 (77%) subjects. The most common HIV subtypes were AE (90%) and B (10%). Five (16.7%) subjects had resistance mutations to nucleoside and non-nucleoside reverse transcriptase inhibitors, and all of them were on cART. No evidence of transmitted drug resistance was found in newly diagnosed individuals. Hospital-based screening may be an efficient method to expand HIV testing and identify a significant number of new cases. Access to care, close monitoring, expansion of anti-retroviral options, and ensuring availability of CD4 determinations, viral load testing, and genotyping are crucial to control of the epidemic in Indonesia. © 2021 by The American Society of Tropical Medicine and Hygiene |
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nonnucleoside reverse transcriptase inhibitor; RNA directed DNA polymerase inhibitor; virus RNA; anti human immunodeficiency virus agent; adolescent; adult; aged; antiretroviral therapy; Article; child; cohort analysis; combination drug therapy; female; fever; genotype; hospital patient; hospitalization; human; Human immunodeficiency virus infection; Indonesia; major clinical study; male; nonhuman; prevalence; prospective study; virus mutation; virus resistance; antiviral resistance; drug effect; genetics; Human immunodeficiency virus 1; Human immunodeficiency virus infection; infant; middle aged; mutation; preschool child; very elderly; virology; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Child; Child, Preschool; Drug Resistance, Viral; Female; HIV Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
|
34460416 |
Article |
Q1 |
1015 |
4298 |
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150 |
Basrowi R.W., Rahayu E.M., Khoe L.C., Wasito E., Sundjaya T. |
57024210400;57275241200;56586245200;6506940239;57188810826; |
The road to healthy ageing: What has indonesia achieved so far? |
2021 |
Nutrients |
13 |
10 |
3441 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115825022&doi=10.3390%2fnu13103441&partnerID=40&md5=71597249210e18c8c5775dcf67e18dbe |
Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Department of Anthropology, Faculty of Social and Political Science Universitas Indonesia, Depok, 16424, Indonesia; Laboratorium Political Psychology, Faculty of Psychology Universitas Indonesia, Depok, 16424, Indonesia |
Basrowi, R.W., Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Rahayu, E.M., Department of Anthropology, Faculty of Social and Political Science Universitas Indonesia, Depok, 16424, Indonesia, Laboratorium Political Psychology, Faculty of Psychology Universitas Indonesia, Depok, 16424, Indonesia; Khoe, L.C., Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Wasito, E., Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Sundjaya, T., Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia |
The World Health Organization (WHO) has projected that the world should prepare for an aging society. As the fourth most populous country in the world, the elderly population in Indonesia is also continuously growing. In 2010, the proportion of the elderly group was merely 5%, and it is expected to increase to 11% in 2035. Understanding the current situation of the adult population in Indonesia would be crucial to prepare for the future aging population. This article analyzed the current socio-demographic status, nutrition status, nutrient intake, and health profile of the current Indonesian adult population through a literature review. The key issues to prepare for healthy aging in Indonesia are summarized. Acknowledging the profile of the adult and senior adult population in Indonesia will provide beneficial information for all stakeholders in preparing Indonesia for a better healthy aging population with improved quality of life. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Aging population; Demographic; Health profile; Healthy ageing; Nutritional status |
adult; aged; demography; female; healthy aging; human; human experiment; Indonesia; Indonesian; male; nutrient intake; nutritional status; quality of life; review; World Health Organization; epidemiology; health status; health survey; Indonesia; nutritional status; socioeconomics; Health Status; Healthy Aging; Humans; Indonesia; Nutritional Status; Public Health Surveillance; Quality of Life; Socioeconomic Factors |
MDPI |
20726643 |
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34684441 |
Review |
Q1 |
1418 |
2497 |
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