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No records
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255 |
Surachman A.J.D., Yanuarso, Akbar D.L. |
57222404106;57222408215;57219271823; |
Corrigendum to “Emergency decompression and stabilization of 1st thoracic spinal cord injury and sacral fracture in a Covid-19 patient: A case report” [Int. J. Surg. 81 (2021) 105670] (International Journal of Surgery Case Reports (2021) 81, (S221026122100170X), (10.1016/j.ijscr.2021.105670)) |
2021 |
International Journal of Surgery Case Reports |
85 |
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106162 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110716581&doi=10.1016%2fj.ijscr.2021.106162&partnerID=40&md5=d755a2c74f6f517c9ab61ce17d1d60b7 |
Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo National Central General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Surachman, A.J.D., Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Yanuarso, Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Akbar, D.L., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo National Central General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The authors regret: [1] The published sentence should have read: “For the pubic diastasis, we did not put any fixation since the diastasis was 1 cm (Fig. 4). When we did the follow up, there was unstable on the diastasis, then we did internal fixation on it and the result of the post surgery was evaluated by pelvic radiograph (Fig. 5) [9].” [2] Fig. 5 should have been published as follows: [3] The authors wish to add the following acknowledgement: “Nadya Zaragita, resident of neurosurgery department of Faculty of Medicine, Universitas Indonesia for making illustration of sacral fracture fixation method.” The authors would like to apologise for any inconvenience caused. © 2021 |
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erratum |
Elsevier Ltd |
22102612 |
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Erratum |
Q3 |
232 |
17549 |
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257 |
Moegni F., Kouwagam A.D. |
55450456100;57225978823; |
Secondary pyosalpinx after reconstructive surgery of vaginal agenesis patient with bilateral hematosalpinx: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106166 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109875443&doi=10.1016%2fj.ijscr.2021.106166&partnerID=40&md5=3efbc39e25d5804ce8b775670c949c8c |
Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Moegni, F., Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kouwagam, A.D., Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Congenital or hypoplasia vaginal agenesis is a very rare condition caused by the failure of developmental Mullerian ducts. The prevalence is 0.001%–0.025% populations. This condition often misdiagnosed because the symptom does not appear. Acute symptoms such as abdominal pain may occur due to the obstruction of retrograde menstrual flow. In this case, we presented a case complex management of vaginal atresia with pyosalpinx, hematometra and bilateral hematosalpinx. Presentation of case: A 12 years old teenager, non-sexually active, complained cyclic abdominal pain that worsening in seven months before admission. Patient never had menstrual blood flow during her life. Patient was diagnosed with hematometra, hematocolpos, bilateral hematosalpinx and distal vaginal agenesis. Amnion graft neovagina was performed. Five days after surgery, patient started to have fever. On the seventh days after surgery, amnion graft was removed. The next two days patient still had fever. Because of continuous fever, patient was test of COVID 19. The result was positive. On the eleventh days after the first surgery, patient complained abdominal pain VAS 3–4. Patient was diagnosed with pyosalpinx by ultrasound examination. Laparotomy was done performing adhesiolysis, bilateral salpingectomy, and omentectomy. Discussion: In our case vaginal reconstruction surgery from vaginal approach has been done without management of the bilateral hematosalpinx because the consideration of small caliber of bilateral hematosalpinx. But then complications were developed when vaginal canal was opened, bilateral hematosalpinx were transformed into bilateral pyosalpinx and continue to developed into bilateral tubal abscess. We assume during this process, the bacteria from vagina could fastly infecting the blood and transformed it into pus and grew until tubal abscess. Conclusion: The surgical intervention in vaginal agenesis must be considered as a treatment and not only focus on the reconstruction. Laparoscopy or laparotomy may offered as options for combination treatment with vaginal approach reconstructive surgery for vaginal agenesis with obstruction complications such as hematometra and hematosalpinx to prevent the worst condition like ascending infection or misdiagnosed other severe conditions. © 2021 The Authors |
Case report; Hematosalpinx complication; Neovagina; Secondary pyosalpinx; Vaginal agenesis |
antibiotic agent; abdominal pain; abscess; adhesiolysis; amnion graft neovagina; antibiotic therapy; Article; bilateral hematosalpinx; bilateral tubal abscess; case report; child; clinical article; coronavirus disease 2019; echography; female; fever; hematocolpos; hematometra; human; laparotomy; omentectomy; primary amenorrhea; salpingectomy; school child; secondary pyosalpinx; surgical technique; uterine tube disease; vagina aplasia; vagina reconstruction; visual analog scale |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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258 |
Fudla H., Mudjihartini N., Khusun H. |
57225017143;57191055759;6506676401; |
Effect of four weeks of 5:2 intermittent fasting on energy intake and body mass index among obese male students aged 18-25 |
2021 |
Obesity Medicine |
25 |
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100353 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108976093&doi=10.1016%2fj.obmed.2021.100353&partnerID=40&md5=bfa31843d67d60cf7f528e73f28417a9 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional (PKGR) Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Fudla, H., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Mudjihartini, N., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Khusun, H., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional (PKGR) Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Obesity is a consequence of the metabolic morbidities caused by overconsumption and lack of physical activity. Etiologically, obesity should be preventable, but reviews show that no country has yet been successful in reducing obesity, even though many efforts have been taken around the globe. This study aimed to assess effects of two non-consecutive days fasting per week on energy intake and body mass index (BMI) among obese male students aged 18–25 years at Universitas Indonesia. The collected data including demographic data, anthropometric, socio-economic status, and self-perception of obesity were used as additional information about obesity incidence as the descriptive data. A randomized controlled trial study was conducted on 40 obese male students. Their habitual intake six months before the study was measured through a semi-quantitative food frequency questionnaire. The BMI was measured using a bioelectrical impedance analysis (BIA). Intervention group did two non-consecutive days fasting per week, and recorded their fasting intake by food record diary; while control group did their habitual eating as before, and being recorded by three days 24-h recall. After a four-week intervention, the intervention group saw a significant reduction (P < 0.005) in energy intake and BMI. IF that properly followed the 5:2 protocol reduced energy intake and BMI among obese male students aged 18–25 at Universitas Indonesia in a four-week intervention. © 2021 Elsevier Ltd |
Calorie restriction; Diet; Intermittent fasting; Obesity; Weight reduction |
adult; anthropometry; Article; attitude to health; body mass; caloric intake; clinical article; controlled study; demography; food frequency questionnaire; human; impedance spectroscopy; incidence; Indonesia; intermittent fasting; male; obesity; randomized controlled trial; self concept; social status; student; therapy effect; treatment duration |
Elsevier Ltd |
24518476 |
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Article |
Q3 |
256 |
16455 |
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262 |
Uchihara Y., Permata T.B.M., Sato H., Shibata A. |
57221723636;57197808751;55697961900;8323572900; |
Modulation of immune responses by DNA damage signaling |
2021 |
DNA Repair |
104 |
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103135 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106368761&doi=10.1016%2fj.dnarep.2021.103135&partnerID=40&md5=6d7c9e9634795d347738b7c970442465 |
Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Gunma University, Gunma, Japan |
Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan |
An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses. © 2021 Elsevier B.V. |
Cancer therapy; DNA damage signaling; Immune crosstalk; Immune-associated disease; Inflammation |
nucleic acid; DNA; Article; cancer immunotherapy; DNA damage response; down regulation; human; immune response; immunomodulation; immunopathology; immunoregulation; inflammation; priority journal; signal transduction; animal; DNA damage; DNA repair; immunity; immunology; metabolism; neoplasm; signal transduction; Animals; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Immunity; Inflammation; Neoplasms; Signal Transduction |
Elsevier B.V. |
15687864 |
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34029876 |
Article |
Q1 |
2359 |
1004 |
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273 |
Wibowo H., Harbuwono D.S., Tahapary D.L., Kartika R., Pradipta S., Larasati R.A. |
57217690943;36056341600;55944492500;57216548032;57212562643;57212549714; |
Impact of Sodium Butyrate Treatment in LPS-Stimulated Peripheral Blood Mononuclear Cells of Poorly Controlled Type 2 DM |
2021 |
Frontiers in Endocrinology |
12 |
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652942 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112435096&doi=10.3389%2ffendo.2021.652942&partnerID=40&md5=351393601155dbe575078ee467f93e21 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biomedicines, Faculty of Medicine, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia |
Wibowo, H., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harbuwono, D.S., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tahapary, D.L., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kartika, R., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pradipta, S., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Larasati, R.A., Department of Biomedicines, Faculty of Medicine, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia |
Type 2 diabetes mellitus (T2DM) is associated with chronic low-grade inflammation, which is marked by the dysregulation of innate and adaptive immune responses. Therefore, reducing inflammation, possibly through an immunoregulatory agent, may play a role in T2DM treatment. Butyrate is the most potent short-chain fatty acid (SCFA), and it exerts anti-inflammatory properties by inhibiting histone deacetylase activity. As an immunoregulatory agent, sodium butyrate can inhibit nuclear factor kB (NF-kB) activation and reduce the production of pro-inflammatory cytokines in immune cells. The aim of the study was to measure the level of plasma butyrate in poorly controlled T2DM and normoglycemic participants and to compare the response of peripheral blood mononuclear cells (PBMCs) to sodium butyrate treatment between the groups by measuring production of the following cytokines: tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-13, and IL-10. The in vitro study examined the PBMCs of 15 participants with poorly controlled T2DM and 15 normoglycemic participants. PBMCs were cultured with the following stimulations for two days at a temperature of 37°C and 5% CO2: 100 ng/mL lipopolysaccharide (LPS), 1 mM sodium butyrate, or a combination of 100 ng/mL LPS and 1 mM sodium butyrate. Plasma butyrate was measured using gas chromatography-mass spectrometry, and cytokines from culture supernatant were analyzed using magnetic beads multiplex assay. Plasma butyrate levels in participants with poorly controlled T2DM did not significantly differ from those in normoglycemic participants (p = 0.105). Compared to treatment with an LPS-stimulated PBMC culture, treatment with 1 mM sodium butyrate reduced the levels of TNF-α (p < 0.039) and IFN-γ (p < 0.038) in normoglycemic participants. The same general trend was seen in PBMC from participants with poorly controlled T2DM, but higher variability appeared to preclude statistical significance. These data suggest that butyrate may modulate inflammatory cytokine production in human PBMCs, but more research is needed to determine if butyrate is anti-inflammatory in poorly controlled T2DM. © Copyright © 2021 Wibowo, Harbuwono, Tahapary, Kartika, Pradipta and Larasati. |
butyrate; inflammatory response; lipopolysaccharide (LPS); peripheral blood mononuclear cells; poorly controlled type 2 diabetes mellitus |
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Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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278 |
Saroyo Y.B., Harzif A.K., Anisa B.M., Charilda F.E. |
57164888400;57191493435;57195936232;57222329284; |
Thyroid storm in the second stage of labour: A case report |
2021 |
BMJ Case Reports |
14 |
7 |
e243159 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111078258&doi=10.1136%2fbcr-2021-243159&partnerID=40&md5=e3ec18b255c13bcad0e9401bfa44b499 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia |
Saroyo, Y.B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Harzif, A.K., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Anisa, B.M., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Charilda, F.E., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia |
A thyroid storm (or thyroid crisis) is an emergency in endocrinology. It is a form of complication of hyperthyroidism that can be life-threatening. Inadequate control of hyperthyroidism in pregnancy could develop into thyroid storm, especially in the peripartum period. We present a woman came in the second stage of labour, with thyroid storm, superimposed pre-eclampsia, acute lung oedema and impending respiratory failure. Treatment for thyroid storm, pre-eclampsia protocol and corticosteroid was delivered. The baby was born uneventfully, while the mother was discharged after 5 days of hospitalisation. Delivery is an important precipitant in the development of thyroid storm in uncontrolled hyperthyroidism in pregnancy. Although very rare, it can cause severe consequences. Diagnosis and treatment guidelines for thyroid storm were available and should be done aggressively and immediately. Uncontrolled hyperthyroidism should be prevented by adequate control in thyroid hormone levels, especially before the peripartum period. © |
endocrinology; obstetrics and gynaecology; thyroid disease |
alanine aminotransferase; aspartate aminotransferase; bicarbonate; corticosteroid; creatinine; dexamethasone; lactate dehydrogenase; lugol; magnesium sulfate; nifedipine; propranolol; propylthiouracil; thyroid hormone; thyrotropin; thyroxine; adult; alanine aminotransferase blood level; ambient air; amnion fluid; Apgar score; Article; aspartate aminotransferase blood level; auscultation; birth length; birth weight; bleeding; blood carbon dioxide tension; blood gas analysis; blood pressure; body temperature; breathing rate; case report; clinical article; clinical examination; clinical feature; consciousness level; continuous positive airway pressure; coronavirus disease 2019; creatinine blood level; diagnostic procedure; disease course; disease duration; disease severity; electrography; epi |
BMJ Publishing Group |
1757790X |
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34290023 |
Article |
Q4 |
231 |
17583 |
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280 |
Pradita L.W., Kamilla D.N., Soedarsono N., Yunaini L., Auerkari E.I. |
57226576844;57226575340;14049161500;57192911515;10139113000; |
Intron 4 VNTR A/B polymorphism of endothelial nitric oxide synthase gene in periodontitis |
2021 |
Journal of Physics: Conference Series |
1943 |
1 |
012087 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112023901&doi=10.1088%2f1742-6596%2f1943%2f1%2f012087&partnerID=40&md5=a0fb2d74d58911990f7e8f70aaf919b9 |
Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Pradita, L.W., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Kamilla, D.N., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia |
Nitric Oxide (NO) is an important mediator in the inflammatory and immune systems. The eNOS gene is one of the three isoforms of Nitric Oxide Synthase (NOS), which is responsible for synthesizing NO. Periodontitis is an inflammatory disease in periodontal tissue with genetic involvement. Polymorphism in eNOS gene changes the functional aspect of this gene and is associated with several inflammatory diseases including periodontitis. Aim: To detect Endothelial Nitric Oxide Synthase intron 4 gene polymorphism in Indonesian population with periodontitis. Analysis of the Endothelial Nitric Oxide Synthase (eNOS) intron 4 gene polymorphism was observed by carrying out PCR method followed by electrophoresis for the analysis, without the usage of restriction enzyme. The chi-square test and odds ratio were performed for statistical analysis. In this study, there were 34 samples with AA genotype, 3 samples with AB genotype, and 13 samples with BB genotype in periodontitis group. Whereas in the control group, there were 41 samples with AA genotype and 9 samples with BB genotype. AB genotype was absent in the control group. In periodontitis group, there were 71 A alleles and 29 B alleles, and in the control group, 82 A alleles and 18 B alleles were found. Polymorphic genotypes and alleles were found higher in periodontitis sample (32% and 29%) than healthy controls (18%). The polymorphism of eNOS intron 4 was found in periodontitis patients. There is no significant distribution difference was found between the periodontitis patients and the control group. ENOS intron 4 gene polymorphism does not affect the risk of periodontitis. © Published under licence by IOP Publishing Ltd. |
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Electrophoresis; Genes; Nitric oxide; Polymerase chain reaction; Polymorphism; Statistical tests; Endothelial nitric oxide synthase; Endothelial nitric-oxide synthase (eNOS); Functional aspects; Gene polymorphism; Inflammatory disease; Nitric-oxide synthase; Periodontal tissue; Restriction enzymes; Diseases |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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281 |
Gani A.Z., Zahra P.K., Soedarsono N., Yunaini L., Auerkari E.I. |
57222626782;57226565453;14049161500;57192911515;10139113000; |
Vitamin D receptor TaqI (rs731236) gene polymorphism in caries patients |
2021 |
Journal of Physics: Conference Series |
1943 |
1 |
012093 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112014710&doi=10.1088%2f1742-6596%2f1943%2f1%2f012093&partnerID=40&md5=5891ab3c26dbd9bd14c0be24643600b3 |
Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Gani, A.Z., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Zahra, P.K., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia |
Vitamin D receptor (VDR) is included in the type of protein that serves as the biological function regulator of vitamin D. Tooth formation, especially in enamel and dentin calcification, as well as maintaining the balance of phosphate and calcium ions which is an important factor in protecting teeth requires support from vitamin D. The VDR gene will regulate the activity of VDR proteins. Caries is a multifactorial disease in which genetic factors can affect the host susceptibility to caries. Polymorphism in the VDR gene is suspected to affect the host susceptibility to caries through changes in calcium metabolism. This study aims to discover the VDR gene polymorphism and its association with caries patients in Indonesia. 100 DNA samples from 100 blood samples, including 50 dental caries patients and 50 healthy controls, were analyzed using PCR-RFLP technique. PCR products were digested with the TaqI restrictive enzyme, then assessed with statistical analysis using Fisher's exact test and Continuity correction test. In the caries group, there were no samples with CC genotype, 4 samples with CT genotype, and 46 samples with TT genotype. There were also 4 C alleles and 96 T alleles. Polymorphic genotypes and alleles were found higher in the caries group (100% and 96%) than healthy controls (88% and 84%). These results conclude that the polymorphism of VDR TaqI (rs731236) gene was found in patients with dental caries. The distribution of genotypes and allele distributions of VDR TaqI (rs731236) gene between caries and healthy controls significantly differs noticeable (p <0.05). © Published under licence by IOP Publishing Ltd. |
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Biomineralization; Calcium; Polymerase chain reaction; Polymorphism; Proteins; Vitamins; Biological functions; Calcium metabolism; Continuity corrections; Gene polymorphism; Healthy controls; Host susceptibility; Multifactorial disease; Vitamin D receptor; Genes |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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282 |
Lazarus G., Wangsaputra V.K., Christianto, Louisa M., Soetikno V., Hamers R.L. |
57214599425;57215576000;57223348000;41461551400;36769252100;23034345900; |
Safety and Pharmacokinetic Profiles of Long-Acting Injectable Antiretroviral Drugs for HIV-1 Pre-Exposure Prophylaxis: A Systematic Review and Meta-analysis of Randomized Trials |
2021 |
Frontiers in Pharmacology |
12 |
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664875 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111311631&doi=10.3389%2ffphar.2021.664875&partnerID=40&md5=708eaf175b9ad89a98ff6679c222f1c7 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wangsaputra, V.K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Christianto, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Objectives: To investigate the safety and pharmacokinetic profiles of long-acting injectable pre-exposure prophylaxis (LAI PrEP), notably cabotegravir (CAB-LA) and rilpivirine (RPV-LA), for the prevention of human immunodeficiency virus-1 (HIV-1) infection. Methods: Eligible randomized trials of LAI PrEP in HIV-uninfected and/or healthy patients were included and assessed with the Revised Cochrane risk-of-bias tool for randomized trials. Where feasible, a meta-analysis was performed for safety outcomes by using a random-effects model with risk ratios and their 95% confidence intervals as the common effect measure. The protocol was registered with PROSPERO CRD42020154772. Results: Eight studies cumulating a total of 666 participants were included in this systematic review, including five (362 intervention-arm volunteers) and four trials (194 intervention-arm volunteers) that investigated CAB-LA and RPV-LA, respectively. We found that both CAB-LA and RPV-LA were generally well-tolerated as their safety profiles were similar to placebo in terms of any adverse event (AE), serious AE, and AE-related withdrawals. Furthermore, pharmacokinetic analyses revealed favorable prospects in viral inhibitory activity of CAB-LA and RPV-LA. Intramuscular (IM) injection of CAB-LA 600 mg Q8W was superior to CAB-LA 800 mg Q12W in male participants, while the same was true for RPV-LA 1200 mg IM Q8W over other dosing regimens. Although these results are promising, further research is required to confirm the findings on RPV-LA as current evidence is limited. Conclusion: CAB-LA and RPV-LA have promising safety and pharmacokinetic profiles. The preventive efficacy of these agents is being evaluated in Phase 3 trials. © Copyright © 2021 Lazarus, Wangsaputra, Christianto, Louisa, Soetikno and Hamers. |
cabotegravir; HIV-human immunodeficiency virus; long acting injectable (LAI); pre-exposure (PrEP) prophylaxis; rilpivirine |
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Frontiers Media S.A. |
16639812 |
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Review |
Q1 |
1384 |
2619 |
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283 |
Meilia P.D.I., Zeegers M.P., Herkutanto, Freeman M.D. |
57204065074;7003691618;57204069374;34769701500; |
Medicolegal causation investigation of bacterial endocarditis associated with an oral surgery practice using the INFERENCE approach |
2021 |
International Journal of Environmental Research and Public Health |
18 |
14 |
7530 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110118162&doi=10.3390%2fijerph18147530&partnerID=40&md5=c18a2f743bdf484bc116e962d9bb593b |
Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Department of Forensic Medicine and Medicolegal Studies, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 4, Salemba, Jakarta Pusat, 10430, Indonesia |
Meilia, P.D.I., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Zeegers, M.P., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Herkutanto, Department of Forensic Medicine and Medicolegal Studies, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 4, Salemba, Jakarta Pusat, 10430, Indonesia; Freeman, M.D., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands |
Investigating causation is a primary goal in forensic/legal medicine, aiming to establish the connection between an unlawful/negligent act and an adverse outcome. In malpractice litigation involving a healthcare-associated infection due to a failure of infection prevention and control prac-tices, the medicolegal causal analysis needs to quantify the individual causal probabilities to meet the evidentiary requirements of the court. In this paper, we present the investigation of the most probable cause of bacterial endocarditis in a patient who underwent an invasive procedure at a dental/oral surgical practice where an outbreak of bacterial endocarditis had already been identified by the state Department of Health. We assessed the probability that the patient’s endocarditis was part of the outbreak versus that it was an unrelated sporadic infection using the INFERENCE (Integration of Forensic Epidemiology and the Rigorous Evaluation of Causation Elements) approach to medicolegal causation analysis. This paper describes the step-by-step application of the INFERENCE approach to demonstrate its utility in quantifying the probability of causation. The use of INFERENCE provides the court with an evidence-based, transparent, and reliable guide to determine liability, causation, and damages. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Bacterial endocarditis; Infection prevention and control practices; INFERENCE approach; Malpractice litigation; Medicolegal causal analysis; Quantification of causation |
bacterium; disease control; forensic science; health care; infectious disease; medicine; oral health; quantitative analysis; adult; aged; aortic regurgitation; Article; bacteremia; bacterial endocarditis; cardiomegaly; dizziness; dyspnea; electrocardiography; emergency ward; Enterococcus faecalis; female; fever; follow up; hospitalization; human; infection prevention; legal epidemiology; lumpectomy; male; malpractice; night sweat; nuclear magnetic resonance imaging; oral surgery; public health; transesophageal echocardiography; bacterial endocarditis; causality; forensic medicine; malpractice; Bacteria (microorganisms); Causality; Endocarditis, Bacterial; Forensic Medicine; Humans; Malpractice; Oral Surgical Procedures |
MDPI |
16617827 |
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34299979 |
Article |
Q2 |
747 |
6560 |
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