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482 |
Siste K., Wiguna T., Bardasono S., Sekartini R., Pandelaki J., Sarasvita R., Suwartono C., Murtani B.J., Damayanti R., Christian H., Sen L.T., Nasrun M.W. |
55644113100;24367785700;57222151719;57224503576;35759266900;50462352200;15078359800;57216652176;57215770702;57209266195;57219034101;57196216137; |
Internet addiction in adolescents: Development and validation of Internet Addiction Diagnostic Questionnaire (KDAI) |
2021 |
Psychiatry Research |
298 |
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113829 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101721252&doi=10.1016%2fj.psychres.2021.113829&partnerID=40&md5=57d16e1d74c98eda3345bc1ba9eca18e |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Indonesia National Narcotics Board, Jakarta, Indonesia; Department of Psychology, Soegijapranata Catholic University, Semarang, Central Java, Indonesia; Faculty of Psychology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bardasono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sekartini, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sarasvita, R., Indonesia National Narcotics Board, Jakarta, Indonesia, Department of Psychology, Soegijapranata Catholic University, Semarang, Central Java, Indonesia; Suwartono, C., Faculty of Psychology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Damayanti, R., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nasrun, M.W., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia- dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Internet addiction (IA) is an emerging behavioral problem that constitutes a major health threat to vulnerable populations, including adolescents. However, there is a paucity of IA screening tools specifically designed for adolescents, especially in Indonesia. Therefore, the current study developed and validated the IA Diagnostic Questionnaire (KDAI) in adolescents while acknowledging local cultural influences. The KDAI was conceived through extensive literature reviews, expert discussions based on Delphi methods, a face validity study, focus group discussion (N = 31) for initial reliability testing, and a recruited pilot study (N = 385) and main study (N = 643) for exploratory and confirmatory factor analyses, respectively. The multi-sample analyses demonstrated that the KDAI model with the best fit and reliability comprised a seven-factor structure, including withdrawal, loss of control, increase of priority, negative consequences, mood modification, salience, and impairment. These factors were scrutinized against domains of IA Test, and concurrent validity was ascertained. Subsequently, a receiver operating characteristic curve and area under the curve determined a cutoff score of 108 to discern adolescents with IA. Taken together, the KDAI displayed excellent psychometric indices and sensitivity as a screening tool for IA in adolescents. © 2021 |
Behavioral addiction; Psychometric characteristic; Screening instrument; Self-report |
adolescent; adult; Article; child; concurrent validity; confirmatory factor analysis; controlled study; cultural anthropology; Delphi study; diagnostic accuracy; diagnostic test accuracy study; exploratory research; face validity; female; human; internet addiction; Internet Addiction Diagnostic Questionnaire; major clinical study; male; mood; pilot study; psychometry; questionnaire; receiver operating characteristic; reference value; reliability; scoring system; self report; sensitivity and specificity; validation study; addiction; Internet; internet addiction; questionnaire; reproducibility; Adolescent; Behavior, Addictive; Humans; Internet; Internet Addiction Disorder; Pilot Projects; Reproducibility of Results; Surveys and Questionnaires |
Elsevier Ireland Ltd |
01651781 |
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33662841 |
Article |
Q1 |
1224 |
3201 |
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No records
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47 |
Craddock N., Garbett K.M., Haywood S., Nasution K., White P., Saraswati L.A., Rizkiah C., Medise B.E., Diedrichs P.C. |
57204036842;56901034200;57339654700;57339654800;55730025700;55842541900;57339370700;57194679894;6504448191; |
‘Dove Confident Me Indonesia: Single Session’: study protocol for a randomised controlled trial to evaluate a school-based body image intervention among Indonesian adolescents |
2021 |
BMC Public Health |
21 |
1 |
2102 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119148188&doi=10.1186%2fs12889-021-11770-0&partnerID=40&md5=081ebeb058ffd74b7c5312132c820642 |
Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; University of Hawaiʻi at Mānoa, Honolulu, United States; Lazuardi Al Falah Depok Junior High School Indonesia, Kota Depok, Indonesia |
Craddock, N., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Garbett, K.M., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Haywood, S., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Nasution, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; White, P., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Saraswati, L.A., University of Hawaiʻi at Mānoa, Honolulu, United States; Rizkiah, C., Lazuardi Al Falah Depok Junior High School Indonesia, Kota Depok, Indonesia; Medise, B.E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Diedrichs, P.C., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom |
Background: Due to the prevalence and associated adverse health consequences of negative body image among adolescents globally, there is a need to develop acceptable, effective, and scalable interventions. School-based body image interventions delivered by trained teachers show promise in reducing negative body image in adolescents. However, there is currently a lack of evidenced-based body image interventions for use in low- and middle-income countries (LMICs). This paper outlines a protocol for the development and evaluation of Dove Confident Me Indonesia: Single Session, a single-session, teacher-led body image intervention for Indonesian adolescents. Method: The effectiveness of the intervention will be evaluated using a cluster randomised controlled trial design. Due to the COVID-19 pandemic, the trial will be conducted online. Trained teachers or school guidance counsellors will deliver the intervention. Self-report questionnaires will be collected at three time points: baseline, post-intervention, and two-month follow-up. The primary outcome is body esteem. Secondary outcomes are internalisation of appearance ideals, mood, engagement in life activities, tendency to engage in appearance comparisons, and skin shade satisfaction. A minimum of 1000 participants will provide 95% power to detect small-to-medium intervention effects. To account for attrition and potential internet issues, the sample will comprise of 2000 Indonesian adolescents in grades 7–9, attending state junior high schools in Surabaya, East Java. Quantitative and qualitative data on acceptability of the intervention will also be collected from teachers and students. Additionally, fidelity of lesson implementation will be assessed. This project received ethical approval from the Universitas Indonesia and the University of the West of England. The intervention will be disseminated in junior high schools throughout Indonesia via UNICEF’s Life Skills Education (LSE) programme, which will be freely available for teachers to download. Discussion: This paper presents Dove Confident Me Indonesia: Single Session, a culturally adapted school-based intervention designed to improve Indonesian adolescents’ body image. It details the plan for evaluation, highlighting the strengths and limitations of the proposed study design. It will be informative for others aiming to adapt evidence-based school curricula to promote well-being among adolescents in LMICs. Trial registration: NCT04665557. Registered 11th December 2020. © 2021, The Author(s). |
Adolescent mental health; Body image; Indonesia; Life skills education; Low- and middle-income countries; Randomised controlled trial; School-based intervention; Single-session intervention; Southeast Asia; Study protocol |
adolescent; body image; human; Indonesia; pandemic; randomized controlled trial (topic); school; school health service; Adolescent; Body Image; COVID-19; Humans; Indonesia; Pandemics; Randomized Controlled Trials as Topic; SARS-CoV-2; School Health Services; Schools |
BioMed Central Ltd |
14712458 |
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34784916 |
Article |
Q1 |
1230 |
3166 |
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55 |
Mansyur M., Sagitasari R., Wangge G., Sulistomo A.B., Kekalih A. |
37085506800;57290722900;36497482500;57024018500;55633562200; |
Long working hours, poor sleep quality, and work-family conflict: determinant factors of fatigue among Indonesian tugboat crewmembers |
2021 |
BMC Public Health |
21 |
1 |
1832 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116761265&doi=10.1186%2fs12889-021-11883-6&partnerID=40&md5=4563534bbfe5b850aae54955a11550c5 |
Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Occupational Medicine Post Graduate Study Program, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Mansyur, M., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Sagitasari, R., Occupational Medicine Post Graduate Study Program, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wangge, G., South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Sulistomo, A.B., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kekalih, A., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Tugboat crewmembers are susceptible to fatigue during their 24-h work shifts, despite the availability of rest time. The fatigue experienced by seafarers contributes to marine accidents and metabolic and cardiovascular diseases, which have long-term effects. This study aimed to analyse the association between working hours and fatigue and other possibly related factors in tugboat crewmembers. Method: This comparative cross-sectional study included 127 tugboat crew members from 15 randomly chosen tugboats in Samarinda Harbor, Indonesia. Their fatigue levels while at work were measured using a reaction timer and standardised questionnaire. Personal and occupational data of crewmembers, including age, marital status, rating (job ranking), duration on board, length of seafaring experience, watch system, smoking status, coffee and alcohol consumption, and working hours, were collected. Moreover, sleep quality and stress levels related to work-family conflict were measured and analysed using the Pittsburgh Sleep Quality Index (PSQI) and Work-Family Conflict Scale (WCFS), respectively. Results: The study found that 40.2% of the subjects were classified as having fatigue. The determinant factors were long working hours (> 72 h/week), poor sleep quality, and work-family conflict [adj. OR = 13.32; 95%-CI (4.78–31.23)] and p < 0.001, [adj. OR = 4.49 (1.39–14.52)] and p = 0.012, [adj. OR = 2.87 (1.12–7.33)] and p = 0.028, respectively. However, personal and occupational factors, including age, marital status, duration on board, length of seafaring experience, smoking status, and coffee and alcohol consumption, were not significantly associated with crewmember fatigue. Conclusion: The incidence of fatigue among Indonesian tugboat crewmembers operating on the Mahakam River was considerably high. Working hours, sleep quality, and work-family conflict were strongly associated with fatigue in tugboat crewmembers; therefore, the working hours of tugboat crewmembers need to be improved. Crewmember lifestyle variables need to be studied further. © 2021, The Author(s). |
Fatigue; Seafarer; Sleep quality; Tugboat crewmembers; Work-family conflict; Working hours |
cross-sectional study; family conflict; fatigue; human; Indonesia; sleep; work schedule; Cross-Sectional Studies; Family Conflict; Fatigue; Humans; Indonesia; Sleep; Work Schedule Tolerance |
BioMed Central Ltd |
14712458 |
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34627227 |
Article |
Q1 |
1230 |
3166 |
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67 |
Liem J.F., Mansyur M., Soemarko D.S., Kekalih A., Subekti I., Suyatna F.D., Suryandari D.A., Malik S.G., Pangaribuan B. |
57224169741;37085506800;57192889490;55633562200;24336854300;56039633100;6505763338;7402973374;54785015100; |
Cumulative exposure characteristics of vegetable farmers exposed to Chlorpyrifos in Central Java – Indonesia; a cross-sectional study |
2021 |
BMC Public Health |
21 |
1 |
1066 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107125504&doi=10.1186%2fs12889-021-11161-5&partnerID=40&md5=9fb7a1aa16134c6ee9e3e23e6280115f |
Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Liem, J.F., Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Mansyur, M., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Soemarko, D.S., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Kekalih, A., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Subekti, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suyatna, F.D., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Pangaribuan, B., Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Background: Agriculture is a major economic sector in Indonesia. Chemical pesticides are widely being used in agriculture for controlling pest. There is a growing concern that pesticide exposure, particularly chlorpyrifos (CPF) exposure, combined with other occupational characteristics that determine the level of exposure, can lead to further health impacts for farmers. Our objective was to evaluate the cumulative exposure characteristics among farmers exposed to CPF by using a validated algorithm. Methods: We conducted a cross-sectional study of 152 vegetable farmers aged 18–65 who actively used CPF for at least 1 year in Central Java, Indonesia. Subject characteristics were obtained using a structured interviewer-administered questionnaire, addressed for sociodemographic and work-related characteristics. The cumulative exposure level (CEL) was estimated as a function of the intensity level of pesticide exposure (IL), lifetime years of pesticide use and the number of days spraying per year. CEL was subsequently classified into two groups, high and low exposure groups. The difference in characteristics of the study population was measured using Chi-square, independent-t or Mann-Whitney test. Association between CEL and its characteristics variables were performed by multiple linear regression. Results: Seventy-one subjects (46.7%) were classified as the high exposure group. The use of multiple pesticide mixtures was common among our study population, with 94% of them using 2 or more pesticides. 73% reported direct contact with concentrated pesticides product, and over 80% reported being splashed or spilt during preparation or spraying activity. However, we found that the proportion of proper personal protective equipment (PPE) use in our subjects was low. Higher volume of mixture applied (p < 0.001) and broader acres of land (p = 0.001) were associated with higher cumulative exposure level, while using long-sleeved clothes and long pants (p < 0.05) during pesticide spraying were associated with lower cumulative exposure after adjusted for age and gender. Conclusions: These findings indicate an inadequate knowledge of using pesticides properly. Thus, we recommend comprehensive training on pesticide usage and encourage proper PPE to reduce the exposure level. © 2021, The Author(s). |
Exposure assessment; Exposure reduction; Occupational characteristics; Pesticide cumulative exposure; Work practices |
chlorpyrifos; pesticide; adverse event; agricultural worker; agriculture; cross-sectional study; epidemiology; human; Indonesia; occupational exposure; vegetable; Agriculture; Chlorpyrifos; Cross-Sectional Studies; Farmers; Humans; Indonesia; Occupational Exposure; Pesticides; Vegetables |
BioMed Central Ltd |
14712458 |
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34090393 |
Article |
Q1 |
1230 |
3166 |
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75 |
Lydia A., Setiati S., Soejono C.H., Istanti R., Marsigit J., Azwar M.K. |
8451287200;14325991900;24472241900;23496653300;57218912589;57202798959; |
Prevalence of prehypertension and its risk factors in midlife and late life: Indonesian family life survey 2014–2015 |
2021 |
BMC Public Health |
21 |
1 |
493 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102501346&doi=10.1186%2fs12889-021-10544-y&partnerID=40&md5=ca5ddee24de31f31b2409c6356d7d7e6 |
Department of Internal Medicine, Division of Nephrology and Hypertension, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Lydia, A., Department of Internal Medicine, Division of Nephrology and Hypertension, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Setiati, S., Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soejono, C.H., Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Istanti, R., Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Marsigit, J., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Azwar, M.K., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Early detection of prehypertension is important to prevent hypertension-related complications, such as cardiovascular disease, cerebrovascular disease and all-cause mortality. Data regarding the prevalence of prehypertension among mid- and late-life population in Indonesia were lacking. It is crucial to obtain the prevalence data and identify the risk factors for prehypertension in Indonesia, which may differ from that of other countries. Methods: The cross-sectional analysis utilized multicenter data from Indonesian Family Life Survey-5 (IFLS-5) from 13 provinces in 2014–2015. We included all subjects at mid-and late-life (aged ≥40 years old) from IFLS-5 with complete blood pressure data and excluded those with prior diagnosis of hypertension. Prehypertension was defined as high-normal blood pressure according to International Society of Hypertension (ISH) 2020 guideline (systolic 130–139 mmHg and/or diastolic 85–89 mmHg). Sociodemographic factors, chronic medical conditions, physical activity, waist circumference and nutritional status were taken into account. Statistical analyses included bivariate and multivariate analyses. Results: There were 5874 subjects included. The prevalence of prehypertension among Indonesian adults aged > 40 years old was 32.5%. Age ≥ 60 years (adjusted OR 1.68, 95% CI 1.41–2.01, p < 0.001), male sex (adjusted OR 1.65, 95% CI 1.45–1.88, p < 0.001), overweight (adjusted OR 1.44, 95% CI 1.22–1.70, p < 0.001), obesity (adjusted OR 1.77, 95% CI 1.48–2.12, p < 0.001), and raised waist circumference (adjusted OR 1.32, 95% CI 1.11–1.56, p = 0.002) were the significant risk factors associated with prehypertension. Prehypertension was inversely associated with being underweight (adjusted OR 0.74, 95% CI 0.59–0.93, p = 0.009). Conclusions: The prevalence of prehypertension in Indonesian mid- and late-life populations is 32.5%. Age ≥ 60 years, male sex, overweight, obesity, and raised waist circumference are risk factors for prehypertension. © 2021, The Author(s). |
Indonesia; Mid- and late-life; Prehypertension; Risk factors |
adult; blood pressure; clinical trial; cross-sectional study; family size; human; hypertension; Indonesia; male; middle aged; multicenter study; prehypertension; prevalence; risk factor; Adult; Blood Pressure; Cross-Sectional Studies; Family Characteristics; Humans; Hypertension; Indonesia; Male; Middle Aged; Prehypertension; Prevalence; Risk Factors |
BioMed Central Ltd |
14712458 |
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33711980 |
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Q1 |
1230 |
3166 |
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No records
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418 |
Ariyanto I.A., Lee S., Estiasari R., Edmands J., Bela B., Soebandrio A., Price P. |
57193538110;56272877300;55240204000;57207355582;24723637900;8602893200;57201814264; |
Understanding the effects of CMV on γδ T-cell populations in HIV patients starting antiretroviral therapy |
2021 |
Clinical Immunology |
226 |
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108696 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103343868&doi=10.1016%2fj.clim.2021.108696&partnerID=40&md5=537b6ce49573252250340726edc3d07d |
Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Pathwest Laboratory Medicine, Perth, Australia; School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Ariyanto, I.A., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lee, S., Department of Microbiology, Pathwest Laboratory Medicine, Perth, Australia, School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Estiasari, R., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Edmands, J., School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Bela, B., Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Price, P., Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia |
Cytomegalovirus (CMV) affects γδ T-cell profiles in healthy individuals and transplant recipients, but the effects of HIV and CMV have not been distinguished in HIV patients. CMV-seropositive Indonesian HIV patients (n = 40) were studied before ART and after six months, alongside healthy controls (n = 20). 50% of patients started ART with detectable CMV DNA. Proportions of Vδ2− γδ T-cells were high in patients and declined on ART, whilst proportions of Vδ2+ γδ T-cells were uniformly low, and correlated inversely with levels of CMV DNA and CMV-reactive antibody. Residual Vδ2+ cells were enriched for markers of terminal differentiation, but this did not associate with CMV metrics. Patients with CMV DNA at baseline showed a direct correlation between CMV reactive-antibody and CD8+ γδ T-cells. Our data are consistent with a role for CMV in the depletion of Vδ2+ γδ T-cells in HIV patients beginning ART, with no consistent evidence of a role for CMV in γδ T-cell activation or differentiation. © 2021 |
Antiretroviral therapy; CMV; HIV; γδ T-cells |
adult; antiretroviral therapy; article; cell population; clinical article; controlled study; Cytomegalovirus; female; gamma delta T lymphocyte; human; human cell; Human immunodeficiency virus infected patient; male; nonhuman; T lymphocyte activation; adolescent; Cytomegalovirus; cytomegalovirus infection; graft recipient; Human immunodeficiency virus infection; immunology; intraepithelial lymphocyte; lymphocyte activation; middle aged; young adult; antiretrovirus agent; lymphocyte antigen receptor; virus antibody; Adolescent; Adult; Anti-Retroviral Agents; Antibodies, Viral; Cytomegalovirus; Cytomegalovirus Infections; Female; HIV Infections; Humans; Intraepithelial Lymphocytes; Lymphocyte Activation; Male; Middle Aged; Receptors, Antigen, T-Cell, gamma-delta; Transplant Recipients; Young |
Academic Press Inc. |
15216616 |
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33621667 |
Article |
Q2 |
1236 |
3138 |
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No records
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56 |
Gunardi E.R., Surya R., Syafitri I., Pasidri Y. |
57192910998;56986345100;57195381844;57226151144; |
Impact of one-rod levonorgestrel implant on the blood chemistry profile |
2021 |
Scientific Reports |
11 |
1 |
20141 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116742568&doi=10.1038%2fs41598-021-99801-z&partnerID=40&md5=604f40cda19708636ac9b97fd82f17a7 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syafitri, I., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The aim of this study was to investigate the effect of a one-rod levonorgestrel implant on the blood chemistry profile, including random blood glucose (RBG), haemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and the lipid profile, including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta, from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated every 6 month up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. p < 0.05 was considered a significant value. The Hb, RBG, AST, and lipid profile levels were significantly different before and 6 months after one-rod implant insertion (p < 0.05). However, for 24 months, all of the parameters were still within normal limits and did not differ clinically. One-rod levonorgestrel implant insertion has a minimal effect on all blood chemistry profiles. © 2021, The Author(s). |
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cholesterol; contraceptive agent; high density lipoprotein cholesterol; levonorgestrel; lipid; low density lipoprotein cholesterol; triacylglycerol; adult; blood; blood analysis; drug implant; female; human; phase 2 clinical trial (topic); procedures; prospective study; young adult; Adult; Blood Chemical Analysis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials, Phase II as Topic; Contraceptive Agents, Female; Drug Implants; Female; Humans; Levonorgestrel; Lipids; Prospective Studies; Triglycerides; Young Adult |
Nature Research |
20452322 |
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34635768 |
Article |
Q1 |
1240 |
3130 |
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63 |
Irwinda R., Hiksas R., Siregar A.A., Saroyo Y.B., Wibowo N. |
57190855256;57226152029;57226157581;57164888400;15049026900; |
Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study |
2021 |
Scientific Reports |
11 |
1 |
14701 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110662198&doi=10.1038%2fs41598-021-93846-w&partnerID=40&md5=f379da0f3a9e78e16af9cc0ca6bb9968 |
Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Siregar, A.A., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Long-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status. © 2021, The Author(s). |
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unsaturated fatty acid; adult; blood; case control study; cross-sectional study; female; human; Indonesia; male; newborn; nutritional status; pathology; preeclampsia; pregnancy; prematurity; severity of illness index; young adult; Adult; Case-Control Studies; Cross-Sectional Studies; Fatty Acids, Unsaturated; Female; Humans; Indonesia; Infant, Newborn; Male; Nutritional Status; Pre-Eclampsia; Pregnancy; Premature Birth; Severity of Illness Index; Young Adult |
Nature Research |
20452322 |
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34282168 |
Article |
Q1 |
1240 |
3130 |
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65 |
Setiawan E.A., Rianda D., Kadim M., Meilianawati, Susanto F., Kok F.J., Shankar A.H., Agustina R. |
57214103232;57214119630;26644177600;57224214324;57224212671;56506613800;7005442634;57214141404; |
Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence |
2021 |
Scientific Reports |
11 |
1 |
11860 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107265110&doi=10.1038%2fs41598-021-88819-y&partnerID=40&md5=ffa4a369e5635d1edafff9d5559b7d3c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Setiawan, E.A., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Rianda, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kadim, M., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Meilianawati, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Susanto, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Kok, F.J., Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Shankar, A.H., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Microbiota and its modification with specific probiotics in early life could provide long term health benefits. Probiotics and calcium strengthen intestinal integrity and may support linear growth. This study investigated the long-term effects of childhood probiotics and calcium supplementation on growth in adolescence. We re-enrolled 238 adolescents aged 11–18 years from 494 children 10-years after 6-months of supplementation with either low-lactose milk fortified with low levels of calcium (LC, ∼50 mg/day, n = 53/124), with regular levels of calcium (RC, ∼440 mg/day, n = 70/126), or with regular calcium + 5 x 108 CFU/day Lactobacillus reuteri DSM 17938 (Reuteri, n = 55/124), or regular calcium + 5 x 108 CFU/day L. casei CRL 431 (Casei, n = 60/120). Changes in height-for-age z-score (HAZ) and body mass index-for-age z-score (BMIZ) were determined from the end of intervention to re-enrollment. General linear models were used to assess the effects on HAZ and BMIZ of group, gender, living area, maternal education, family income, physical activity, diet quality, nutritional status, and gut integrity as determined by urinary lactulose/mannitol ratio (L:M). Adolescent mean age was 15.3 years, mean HAZ was − 1.11, mean BMIZ was − 0.2 and median L:M (n = 155) was 0.23. Changes in HAZ and BMIZ were not significantly different between Casei, Reuteri, LC compared to RC. However, a significant decrease in BMIZ was observed among female adolescents in the Casei compared to RC group (− 0.5 SD, 95% CI − 0.8 to − 0.003, p = 0.048). Childhood probiotic and calcium supplementation may therefore selectively affect female adolescents. Clinical trial registration: This follow-up study has been registered at www.clinicaltrials.gov, Registry name: Rina Agustina, Registration number: NCT04046289, First Registration Date 06/08/19. web link: https://www.clinicaltrials.gov/ct2/show/NCT04046289. © 2021, The Author(s). |
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lactulose; mannitol; probiotic agent; administration and dosage; adolescent; body height; body mass; body weight; calcium intake; controlled study; diet therapy; dietary supplement; double blind procedure; epidemiology; female; follow up; fortified food; health auxiliary; human; Indonesia; Lactobacillus casei; Lactobacillus reuteri; male; nutritional status; randomized controlled trial; risk factor; statistical model; Adolescent; Body Height; Body Mass Index; Body Weight; Calcium, Dietary; Community Health Workers; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies; Food, Fortified; Humans; Indonesia; Lactobacillus casei; Lactobacillus reuteri; Lactulose; Linear Models; Male; Mannitol; Nutrition Therapy; Nutritional Status; Probiotics; Risk Factors |
Nature Research |
20452322 |
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34088920 |
Article |
Q1 |
1240 |
3130 |
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