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57	Diptyanusa A., Sari I.P.	57205340891;57197543698;	Treatment of human intestinal cryptosporidiosis: A review of published clinical trials	2021	International Journal for Parasitology: Drugs and Drug Resistance	17		128	138		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115755098&doi=10.1016%2fj.ijpddr.2021.09.001&partnerID=40&md5=e7d5494025a277d99586bf5f73027625	Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia; Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia	Diptyanusa, A., Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia, Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia	The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis can result in long-term morbidity and high illness costs. The evidence of effective treatments for cryptosporidiosis has been lacking. We reviewed the published clinical trials to bring forward the feasible therapeutic options of human cryptosporidiosis in various populations and settings according to clinical improvement and parasite clearance rates. A total of 42 studies consisting of the use of nitazoxanide, paromomycin, macrolides, somatostatin analogues, letrazuril, albendazole, rifaximin, miltefosine, clofazimine, and colostrum were included in the review. The trials were mostly conducted in small number of individuals infected with human immunodeficiency virus (HIV), and there is inadequate data of controlled trials to suggest the use of these treatment modalities. Nitazoxanide was reported to be highly efficacious only in immunocompetent hosts and was found to be superior to paromomycin in the same group of patients. Macrolides showed no effective results in both clinical and parasitological improvement. Human bovine colostrum should possibly be administered as one of complementary therapeutic modalities along with other antimicrobials to reach optimal parasite eradication. Other trials of therapeutic modalities were terminated due to futility. Currently, available data is intended to aid the development of strategies for improving access to treatments in different clinical settings, as well as to help guide further studies on treatments of human intestinal cryptosporidiosis. © 2021	Clearance; Clinical trial; Cryptosporidiosis; Cryptosporidium; Drug; Treatment	acetylspiramycin; albendazole; alkaline phosphatase; antiparasitic agent; azithromycin; clofazimine; erythromycin; garlicin; immunoglobulin; letrazuril; macrolide; miltefosine; nitazoxanide; octreotide; paromomycin; placebo; probiotic agent; rifaximin; roxithromycin; somatostatin derivative; spiramycin; unclassified drug; vapreotide; antiprotozoal agent; paromomycin; abdominal pain; adolescent; adult; aged; alkaline phosphatase level; alternative medicine; anorexia; antiparasitic therapy; child; cholecystitis; clinical trial (topic); colostrum; constipation; cryptosporidiosis; diarrhea; dizziness; drowsiness; drug efficacy; fatigue; fever; headache; health care access; human; Human immunodeficiency virus infection; hypertransaminasemia; infant; injection site pain; intestine obstruction; k	Elsevier Ltd	22113207	34562754	Review	Q1	1071	3953	View
66	Pranata R., Yonas E., Huang I., Lim M.A., Nasution S.A., Kuswardhani R.A.T.	57201973901;57201987097;57208576645;57216039756;57189373134;36863900500;	Fibrosis-4 index and mortality in coronavirus disease 2019: a meta-analysis	2021	European journal of gastroenterology & hepatology	33	1S Suppl 1	e368	e374	8	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107230733&doi=10.1097%2fMEG.0000000000002091&partnerID=40&md5=ea06112f412d95910a1757cc5756c08a	Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSIJakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Indonesia	Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSIJakarta, Indonesia; Huang, I., Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Nasution, S.A., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Kuswardhani, R.A.T., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Indonesia	BACKGROUND/AIMS: In this meta-analysis, we aimed to evaluate the prognostic value of fibrosis-4 index (FIB-4) in COVID-19. METHODS: We performed a comprehensive literature search of PubMed, Embase, and Scopus databases on 26 November 2020. FIB-4 was calculated by [age (years) × AST (IU/L)]/[platelet count (109/L) × √ALT (U/L)]. A value above cutoff point was considered high and a value below cutoff point was considered low. The main outcome was mortality, the association between high FIB-4 and mortality was reported in odds ratio (OR). Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic OR (DOR), area under the curve (AUC) were generated. RESULTS: There were 963 patients from five studies included in this systematic review and meta-analysis. Meta-analysis showed that high FIB-4 was associated with increased mortality [OR 3.96 (2.16-7.27), P < 0.001; I2: 41.3%]. High FIB-4 was associated mortality with a sensitivity of 0.56 (0.40-0.70), specificity of 0.80 (0.72-0.86), PLR 2.8 (1.8-4.2), NLR 0.55 (0.39-0.78), DOR 5 (2-10), and AUC of 0.77 (0.73-0.81). Fagan's nomogram indicated that for a pre-test probability (mortality) of 30%, a high FIB-4 was associated with 54% post-test probability and a low FIB-4 was associated with 19%, respectively. The funnel-plot analysis was asymmetrical, trim-and-fill analysis by imputation of a study on the left side using linear estimator resulted in an OR of 3.48 (1.97-6.14). Egger's test showed no indication of small-study effects (P = 0.881). CONCLUSION: High FIB-4 was associated with mortality in patients with COVID-19. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.		area under the curve; fibrosis; human; meta analysis; platelet count; Area Under Curve; COVID-19; Fibrosis; Humans; Platelet Count; SARS-CoV-2	NLM (Medline)	14735687	35048648	Article	#N/A	#N/A	#N/A	View
71	Tandaju J.R., Li W., Pateras K., Georgiopoulos G.	57222662533;57369633600;57200224369;57188877741;	Deriving cut-off values for continuous predictors of severe outcomes in COVID-19 through meta-analysis of individual studies	2021	American Journal of Emergency Medicine	50		799		1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104938971&doi=10.1016%2fj.ajem.2021.03.029&partnerID=40&md5=b4a3015c95a454387a73134ab5845aa6	Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom; Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athen, Greece	Tandaju, J.R., Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; Li, W., The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Pateras, K., Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Georgiopoulos, G., School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athen, Greece	[No abstract available]		clinical outcome; coronavirus disease 2019; disease severity; human; Letter; COVID-19; Humans; SARS-CoV-2	W.B. Saunders	07356757	33958246	Letter	Q1	725	6828	View
81	Raharja A., Tamara A., Kok L.T.	57192080346;57205305387;57219901696;	Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis	2021	Journal of Racial and Ethnic Health Disparities	8	6	1563	1572	8	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096023866&doi=10.1007%2fs40615-020-00921-5&partnerID=40&md5=139e8ff070e1e792a6383269e01b7342	Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Raharja, A., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Tamara, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kok, L.T., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom	Objectives: This article evaluates if ethnicity is an independent poor prognostic factor in COVID-19 disease. Methods: MEDLINE, EMBASE, Cochrane, WHO COVID-19 databases from inception to 15/06/2020 and medRxiv. No language restriction. Newcastle-Ottawa Scale (NOS) and GRADE framework were utilised to assess the risk of bias and certainty of evidence. PROSPERO CRD42020188421. Results: Seventy-two articles (59 cohort studies with 17,950,989 participants, 13 ecological studies; 54 US-based, 15 UK-based; 41 peer-reviewed) were included for systematic review and 45 for meta-analyses. Risk of bias was low: median NOS 7 of 9 (interquartile range 6–8). Compared to White ethnicity, unadjusted all-cause mortality was similar in Black (RR: 0.96 [95% CI: 0.83–1.08]) and Asian (RR: 0.99 [0.85–1.16]) but reduced in Hispanic ethnicity (RR: 0.69 [0.57–0.84]). Age- and sex-adjusted risks were significantly elevated for Black (HR: 1.38 [1.09–1.75]) and Asian (HR: 1.42 [1.15–1.75]), but not for Hispanic (RR: 1.14 [0.93–1.40]). Further adjusting for comorbidities attenuated these associations to non-significance: Black (HR: 0.95 [0.72–1.25]); Asian (HR: 1.17 [0.84–1.63]); Hispanic (HR: 0.94 [0.63–1.44]). Subgroup analyses showed a trend towards greater disparity in outcomes for UK ethnic minorities, especially hospitalisation risk. Conclusions: This review could not confirm a certain ethnicity as an independent poor prognostic factor for COVID-19. Racial disparities in COVID-19 outcomes may be partially attributed to higher comorbidity rates in certain ethnicity. © 2020, W. Montague Cobb-NMA Health Institute.	Acute kidney injury; COVID-19; Ethnicity; Hospitalisation; Intubation; Mortality	ethnicity; ethnology; human; meta analysis; patient acuity; prognosis; risk factor; therapy; COVID-19; Ethnicity; Humans; Patient Acuity; Prognosis; Risk Factors	Springer Science and Business Media Deutschland GmbH	21973792	33180278	Review	Q1	644	7820	View
82	Amanda G., Tafroji W., Sutoyo D.K., Burhan E., Haryanto B., Safari D.	57193071364;57118271600;6506079672;36058554600;41861500300;23493586700;	Serotype distribution and antimicrobial profile of Streptococcus pneumoniae isolated from adult patients with community-acquired pneumonia in Jakarta, Indonesia	2021	Journal of Microbiology, Immunology and Infection	54	6	1175	1178	2	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094592942&doi=10.1016%2fj.jmii.2020.10.003&partnerID=40&md5=9c2a2f417f1387a35bf85921e1b795f4	Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Microbiology, Persahabatan Hospital, Jakarta, Indonesia	Amanda, G., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sutoyo, D.K., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Burhan, E., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Haryanto, B., Department of Microbiology, Persahabatan Hospital, Jakarta, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia	Streptococcus pneumoniae is one of the primary causes of community-acquired pneumonia. The vaccine serotypes were dominant and could be isolated in 14% of adult patients, with serotype 3 being the most predominant (25%), followed by 6A, 6B, and 7F. Approximately, 44% of the isolates showed resistance to tetracycline. © 2020	Antibiotic resistance profile; Community-acquired pneumonia; Serotype; Streptococcus pneumoniae	antiinfective agent; adolescent; adult; antibiotic resistance; community acquired infection; cross-sectional study; drug effect; female; genetics; human; Indonesia; isolation and purification; male; microbiology; middle aged; pneumonia; serotype; Streptococcus pneumoniae; young adult; Adolescent; Adult; Anti-Bacterial Agents; Community-Acquired Infections; Cross-Sectional Studies; Drug Resistance, Bacterial; Female; Humans; Indonesia; Male; Middle Aged; Pneumonia; Serogroup; Streptococcus pneumoniae; Young Adult	Elsevier Ltd	16841182	33268305	Article	Q1	1223	3210	View
84	Makmun D., Simadibrata M., Abdullah M., Syam A.F., Shatri H., Fauzi A., Renaldi K., Maulahela H., Utari A.P., Pribadi R.R., Muzellina V.N., Nursyirwan S.A.	16638046900;23499598400;7103393434;8443384400;28767986500;36518523000;57190963547;57189612709;57113585900;57194732282;57223968527;57249143800;	Retrospective Study Colorectal cancer patients in a tertiary hospital in Indonesia: Prevalence of the younger population and associated factors	2021	World Journal of Clinical Cases	9	32	9804	9814		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119652838&doi=10.12998%2fwjcc.v9.i32.9804&partnerID=40&md5=75cf4743775cd03169188a4206cb7cb0	Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia	Makmun, D., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Simadibrata, M., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Abdullah, M., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Syam, A.F., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Shatri, H., Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Fauzi, A., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Renaldi, K., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Maulahela, H., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Utari, A.P., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Pribadi, R.R., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Muzellina, V.N., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia	BACKGROUND An increasing trend in colorectal cancer (CRC) occurring at younger ages has been observed worldwide, even though incidence is declining in the general population. Most currently available guidelines still recommend CRC screening for older populations, despite an alarming rise in early-onset CRC incidence. Risk stratification is necessary to further determine the population most at risk for early-onset CRC. However, epidemiological data on related clinical characteristics and potential risk factors, especially in developing countries, have not been widely reported. AIM To investigate the prevalence, demographics, clinicopathologic features, and associated factors of young-onset CRC patients in a tertiary hospital in Indonesia. METHODS Patients undergoing colonoscopy examination between 2008 and 2019, yielding a diagnosis of CRC were identified from medical records. The subjects were classified into two groups according to their age at diagnosis, namely early-onset (18–49 years old) and late-onset (≥ 50-years-old). Demographic data, characteristics, and risk factors of both onset age groups were evaluated using the chisquare and Fisher’s exact test. RESULTS Among 495 CRC patients confirmed by histopathology, 205 (41.4%) were classified as early-onset and 290 (58.6%) as late-onset. Most subjects in the early-onset CRC group were male (53.7%), with 89.8% displaying adenocarcinoma histopathology. A majority (78%) of the early-onset CRC patients had left-sided tumors, with the rectum (41%) and rectosigmoid (17.6%) being the most common sites. Abdominal pain was the most frequent symptom in the early-onset CRC patients (55.6%), which was significantly higher than that in the late-onset CRC patients (43.8%, P > 0.05). Early-onset CRC cases were more likely to be underweight (34.6% vs 20.0%, P < 0.001) compared to late-onset CRC cases. The proportion of subjects with suspected hereditary nonpolyposis colorectal cancer (HNPCC) was also higher in the early-onset CRC group than in the late-onset age group (9.3% vs 4.1%, P < 0.05). However, no difference was observed in the parental or family histories of CRC cases. CONCLUSION Early-onset CRC patients were more likely to have abdominal pain, underweight status, and HNPCC suspicion than late-onset CRC patients. © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.	Associated factors; Colorectal cancer; Early onset; Epidemiology; Indonesia; Tertiary hospital	abdominal pain; adenocarcinoma; adult; aged; Article; body mass; carcinoid; colon; colonoscopy; colorectal cancer; cross-sectional study; diabetes mellitus; familial adenomatous polyposis; female; hereditary nonpolyposis colorectal cancer; histopathology; human; human tissue; hypertension; major clinical study; male; medical record; obesity; prevalence; rectum; rectum hemorrhage; retrospective study; risk factor; smoking; underweight; very elderly	Baishideng Publishing Group Co	23078960		Article	Q3	368	12908	View
87	Miranda E., Bramono K., Rizky L.A., Hayun	57208259598;9843236700;57193502812;37053937800;	Preparation and stability evaluation of ll-37 cream	2021	International Journal of Applied Pharmaceutics	13	6	139	143		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121048883&doi=10.22159%2fIJAP.2021V13I6.39639&partnerID=40&md5=1b6a1a02cc0417196461dd2568afa7d5	Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia	Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rizky, L.A., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hayun, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia	Objective: The present study aimed to prepare LL-37 in a cream formulation (O/W emulsion) and evaluate its stability by determining the physical changes in the cream and concentration of LL-37 using validated high-performance liquid chromatography. Methods: The method was conducted at room temperature using a C18 column (5 µm × 250 mm × 4.6 mm) as a stationary phase, a mixture of 0.1% trifluoroacetic acid (TFA)/water (A) and 0.1% TFA/acetonitrile (B) (85:15) as the mobile phase, a flow rate of 1.0mL/min, an d photodiode array set at 228 nm as the detector. The method was validated in compliance with the Association of Official Analytical Chemists and International Conference on Harmonization guidelines. It demonstrated excellent linearity, accuracy, precision, specificity, the limit of detection, and limit of quantitation. Results: The chromatographic analysis indicated minimal degradation of LL-37 during the 12-week, with a predicted expiry time of 99 and 75 mo stored at 4 °C and 28 °C, respectively. Conclusion: LL-37 cream establishes good physical characteristics and stabilizes the active ingredient, especially at 4 °C and 28 °C storage. Therefore, the emulsion delivery system of LL-37 cream is harmless and stable as a novel alternative vehicle of LL-37. © 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd.	Cream; High-performance liquid chromatography; LL-37; Stability		Innovare Academics Sciences Pvt. Ltd	09757058		Article	Q3	238	17272	View
91	Renaldi K., Simadibrata M., Rahadiani N., Handjari D.R., William A., Sinuraya F., Makmun D.	57190963547;23499598400;16426455700;56160657900;57209025962;57212478117;16638046900;	Prognostic Value of COX-2, NF-κB, and Sp1 Tissue Expressions in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis	2021	The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology	32	11	956	970		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122454127&doi=10.5152%2ftjg.2021.211106&partnerID=40&md5=869f590f4b509a9d15f5495cd1423389	Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia	Renaldi, K., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Simadibrata, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Rahadiani, N., Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; Handjari, D.R., Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; William, A., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Sinuraya, F., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Makmun, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia	BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is deadly cancer with a poor prognosis. Molecular prognostic markers are needed to predict the patient's survival. The cyclooxygenase-2 enzyme (COX-2) and its 2 major transcription factors--nuclear factorkappa B (NF-κB) and specificity protein 1 (Sp1)--are activated during inflammation caused by neoplasia. Several studies have investigated the association between the COX-2, NF-κB, and Sp1 tissue expressions with the patient's overall survival. Therefore, we conducted this systematic review and meta-analysis to evaluate those studies. METHODS: We searched for relevant articles from the MEDLINE database through June 2020. Studies were eligible if they included dichotomized tissue protein expression status and the overall survival as the outcome. We used RevMan and ProMeta programs to perform the meta-analysis. RESULTS: We identified 11 eligible studies. The meta-analysis showed that COX-2 tissue expression was associated with decreased overall survival (crude HR = 1.35; 95% CI, 1.05-1.74), although the result was not significant when controlling for other covariates. The NF-κB tissue expression was associated with decreased overall survival (crude HR = 2.18; 95% CI, 1.49-3.18), although it was not significant when controlling for other covariates. The Sp1 tissue expression showed significantly decreased overall survival even when adjusted with other covariates (aHR = 3.47; 95% CI, 1.52-7.94). The limitations included searching only for English publications and the substantial heterogeneity among the studies. CONCLUSION: COX-2, NF-κB, and Sp1 tissue expressions have the potential to be used as prognostic markers in PDAC. Further studies are still needed to clarify the associations.		cyclooxygenase 2; immunoglobulin enhancer binding protein; Sp1 protein, human; transcription factor Sp1; tumor marker; human; meta analysis; metabolism; pancreas carcinoma; pancreas tumor; prognosis; tissue distribution; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cyclooxygenase 2; Humans; NF-kappa B; Pancreatic Neoplasms; Prognosis; Sp1 Transcription Factor; Tissue Distribution	NLM (Medline)	21485607	34872897	Article	#N/A	#N/A	#N/A	View
92	Habiburrahman M., Ariq H., Handayani R.R.D.	57204537114;57252668400;57394104600;	Combining LAMP and Au-Nanoprobe to detect INH-RIF resistance accurately in tuberculosis: An evidence-based review	2021	Journal of Infection in Developing Countries	15	11	1555	1568		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122149394&doi=10.3855%2fJIDC.15188&partnerID=40&md5=6f29dbd01464318f481e0062398c92a4	Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia	Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariq, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handayani, R.R.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia	Approximately 1.41 million people die annually due to tuberculosis. One of the main problems in Tuberculosis eradication is the development of resistance to various antibiotics. However, current efforts to detect resistances face challenges such as limited equipment, budget, and time. This evidence-based review investigated loop-mediated isothermal amplification, an alternative molecular diagnostic tool with promising performance and applicability in developing countries, and its use combined with Au-Nanoprobe to detect antibiotic resistance in tuberculosis. The literature search was conducted through four databases (Proquest, EBSCOhost, Scopus, and Pubmed) for useful articles on loop-mediated isothermal amplification and Au-Nanoprobe in detecting tuberculosis and tuberculosis resistance. After filtering the result with inclusion and exclusion criteria, the search produced three papers that best answer the clinical question. Loop-mediated isothermal amplification amplifies a target sequence, and Au-Nanoprobe responds to the DNA specific to the target mutant, producing an observable color change. Loop-mediated isothermal amplification and Au-Nanoprobe showed 100% sensitivity and specificity in detecting rifampicin and isoniazid resistance. Another study investigated its viability to detect tuberculosis and found 98.2% sensitivity and 88.2% specificity. Combining loop-mediated isothermal amplification and Au-Nanoprobe had a shorter time to get results and should also be relatively cheaper because it does not need a high temperature to work and requires less equipment. In conclusion, loop-mediated isothermal amplification and Au-Nanoprobe can be used as an efficient and accurate method to detect isoniazid and rifampicin-resistant tuberculosis strains. The new technology is promising for developing countries due to their high disease burden but facing several healthcare barriers. Copyright © 2021 Habiburrahman et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	Au-Nanoprobes; Diagnosis; Isoniazid; Loop-mediated isothermal amplification; Multidrug-resistant tuberculosis; Rifampicin	aflatoxin B1; antibiotic agent; betaine; catalase; gold; gold nanoparticle; isoniazid; isoniazid plus rifampicin; penicillin derivative; rifampicin; rifapentine; bacterial DNA; isoniazid; rifampicin; tuberculostatic agent; antibiotic resistance; blood culture; cost effectiveness analysis; developing country; disease burden; DNA extraction; filtration; gene amplification; genotype; high temperature; human; loop mediated isothermal amplification; Medline; molecular diagnosis; multiplex polymerase chain reaction; Mycobacterium tuberculosis; nonhuman; nucleotide sequence; polymerase chain reaction; Review; rifampicin resistance; Scopus; sputum cytodiagnosis; sputum smear; Streptococcus pneumoniae; surface plasmon resonance; systematic review; temperature; tuberculosis; multidrug resistant tube	Journal of Infection in Developing Countries	20366590	34898479	Review	Q3	322	14136	View
93	Zizlavsky S., Anam K., Suwento R., Rahmawati I.	57195721920;57474576600;55743638800;57372516200;	The effects of Goldenhar Syndrome on hearing and speech development	2021	Medical Journal of Malaysia	76	6	946	949		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121118699&partnerID=40&md5=ccde190cb788d0255d331b7adfe1295c	Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Zizlavsky, S., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Anam, K., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suwento, R., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmawati, I., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Goldenhar syndrome is a congenital abnormality with an incidence of 1 in 5,200 to 26,500 births. This syndrome is characterized by facial asymmetry, ear malformation, and/or defects in the eyes and vertebrae. The hearing disorder manifests as both conductive or sensorineural due to the abnormalities occurring in the inner and outer ear. We report a case of a 1-year-3-month-old child presenting with left anotia and right microtia, severe bilateral conductive hearing loss, and global delayed development. The patient was also found to have a hemifacial microsomia, a secundum atrial septal defect (ASD), and a ventricular septal defect (VSD). The patient was advised to use hearing aids and participate in speech therapy. The management of this Goldenhar syndrome patient should be done comprehensively, appropriate to the abnormalities found to achieve the best result. © 2021, Malaysian Medical Association. All rights reserved.		anterior inferior cerebellar artery; Article; audiology; babbling; blue light; brainstem evoked response audiometry; case report; clinical article; conduction deafness; cranial nerve paralysis; dyspnea; ear malformation; electrophysiological response; face asymmetry; face deformity; Goldenhar syndrome; hearing; hearing disorder; hearing examination; hearing function; heart atrium septum defect; heart disease; heart ventricle septum defect; hemifacial microsomia; human; hyperbilirubinemia; infant; lagophthalmos; loud noise; male; micrognathia; microtia; motor development; nuclear magnetic resonance imaging; parasystolic murmur; perception deafness; ptosis (eyelid); radiodiagnosis; speech development; speech therapy	Malaysian Medical Association	03005283	34806693	Article	Q4	193	19818	View

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