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94 |
Subahar R., Susanto L., Aidilla R., Aulia A.P., Yulhasri Y., Winita R., Lubis N.S., Sari I.P. |
6508197883;6507704130;57365800900;57366528800;57225180520;57220782528;57222661567;57197543698; |
In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron microscopic changes in lice |
2021 |
Veterinary World |
14 |
11 |
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3065 |
3075 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120814548&doi=10.14202%2fvetworld.2021.3065-3075&partnerID=40&md5=1d1646983a8b7f7da98a7d4f5896e795 |
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia |
Subahar, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Susanto, L., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Aidilla, R., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Aulia, A.P., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia; Winita, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Lubis, N.S., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia |
Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). Materials and Methods: The adult stages of P. h. capitis were collected from patients exposed to 1% permethrin and three different concentrations of 6-paradol (0.00005%, 0.0001%, and 0.00015%) using a filter paper diffusion bioassay. Healthy P. h. capitis adults served as the control. The in vitro bioassays were conducted after 10, 20, 30, and 60 min of exposure. The activities of acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase were analyzed. Physical changes in the lice were analyzed using SEM. Results: Permethrin and 6-paradol exhibited low toxicity against the lice. At 60 min, 1% permethrin had killed 36.7% of the lice present, while 6-paradol had killed 66.7-86.7%. Permethrin induced significantly elevated AChE, GST, and oxidase activity; 6-paradol also caused significantly elevated AChE, GST, and oxidase activity. Permethrin did not cause any ultrastructural morphological changes on the lice, while 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. Conclusion: This in vitro experimental of P. h. capitis is the first study to report P. h. capitis in East Jakarta shows complete resistance to permethrin and 6-paradol, and to describe the associated increase in AChE, GST, and oxidase activity. It was observed that 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. © 2021 Veterinary World. All rights reserved. |
6-paradol; Detoxifying enzyme; Electron microscopy; Pediculus humanus capitis; Permethrin; Resistance |
6 paradol; acetylcholinesterase; chitin; glutathione transferase; oxidoreductase; permethrin; phenol derivative; unclassified drug; Article; bioassay; controlled study; detoxification; diffusion; enzyme activity; enzyme linked immunosorbent assay; hair loss; LT50; LT90; nonhuman; Pediculus humanus capitis; scanning electron microscopy; ultrastructure |
Veterinary World |
09728988 |
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Article |
Q2 |
550 |
9187 |
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95 |
Laksmita Y.A., Sidik M., Siregar N.C., Nusanti S. |
57209279067;57257519600;6508087790;57189727162; |
Neuroprotective Effects of Citicoline on Methanol-Intoxicated Retina Model in Rats |
2021 |
Journal of Ocular Pharmacology and Therapeutics |
37 |
9 |
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534 |
541 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120545903&doi=10.1089%2fjop.2021.0018&partnerID=40&md5=cfe07289839f2866220d3438db7fac57 |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Laksmita, Y.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Sidik, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nusanti, S., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia |
Purpose: This study aims to evaluate the effect of citicoline administration in suppressing retinal damage due to methanol intoxication. This study hypothesizes that citicoline will minimize the loss of retinal ganglion cells (RGCs), minimize disruption of photoreceptors, suppress ganglion layer edema, increase expression of bcl-2 as the antiapoptotic protein, and decrease expression of caspase-3 as the proapoptotic protein. Methods: Fifteen Sprague-Dawley rats were divided into 5 groups, including the control group (A); methanol groups, observed on day 3 (B1) and day 7 (B2); and methanol+citicoline groups, observed on day 3 (C1) and day 7 (C2). Rats in groups B and C were placed in an inhalation chamber filled with N2O:O2 during the experiment, then methanol was administered orally. Citicoline, 1 g/kg every 24 h, was orally administered for group C. Enucleation was performed and retinas of rats were prepared for histology and immunohistochemistry examination to evaluate photoreceptor morphology and RGC density, as well as bcl-2 and caspase-3 expression. Results: RGC density of citicoline-treated intoxicated rats was higher than no-citicoline methanol-intoxicated rats on both day 3 (P < 0.001) and day 7 (P < 0.001). The ganglion layer thickness of citicoline-treated intoxicated rats was thinner than no-citicoline intoxicated rats, which means citicoline-treated rats had milder ganglion layer edema. Citicoline-treated rats showed higher bcl-2 and lower caspase-3 expression than no-citicoline rats. No differences were found in photoreceptor findings among groups. Conclusions: This study demonstrated citicoline's potential benefits for management of ocular methanol intoxication. However, more preclinical and clinical trials are needed to obtain a preferred dosage and timing of citicoline administration. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
citicoline; methanol intoxication; methanol optic neuropathy; neuroprotector; retina; toxic optic neuropathy |
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Mary Ann Liebert Inc. |
10807683 |
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34495749 |
Article |
Q2 |
727 |
6812 |
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96 |
Irwinda R., Hiksas R., Lokeswara A.W., Wibowo N. |
57190855256;57226152029;57200937543;15049026900; |
Maternal and fetal characteristics to predict c-section delivery: A scoring system for pregnant women |
2021 |
Women's Health |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120494500&doi=10.1177%2f17455065211061969&partnerID=40&md5=24bd3b15eeeb46e6e6583c50495d671b |
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lokeswara, A.W., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Cesarean section is one of the most common obstetrical interventions that has been performed at an increasing rate globally, due to both medical and non-medical reasons. This study aims to develop a prediction tool for pregnant women potentially needing c-section, such that necessary preparations from the mothers, families, and health providers can be made. Methods: A total of 603 pregnant women were recruited in the first phase of c-section prediction tool development. The association between the maternal and fetal factors on the risk of c-section were analyzed, followed by a stepwise multivariate regression analysis. In the next phase, 61 pregnant women were enrolled for external validation. Discrimination was assessed using area under the curve. The calibration plot was then made and assessed using the Hosmer–Lemeshow test. Results: There were 251 (41.6%) cases of vaginal delivery and 352 (58.4%) of c-section assessed. Multivariate analysis showed that gestational age < 37 wg (OR: 1.66, 95% CI: 1.10–2.51), pre-pregnancy body mass index (underweight) (OR: 0.40, 95% CI: 0.22–0.76), no history of vaginal delivery (OR: 2.66, 95% CI: 1.76–4.02), history of uterine surgery (OR: 8.34, 95% CI: 4.54–15.30), obstetrical complications (OR: 5.61, 95% CI: 3.53–8.90), birthweight ⩾ 3500 g (OR: 4.28, 95% CI: 2.16–8.47), and non-cephalic presentation (OR: 2.74, 95% CI: 1.53–4.89) were independently associated with c-section delivery. Those parameters were included in a 7-item scoring tool, with consecutive predictive scores of 1,–1,2,3,3,2,2,1. The area under the curve result was 0.813 (95% CI: 0.779–0.847), indicating a good predictive ability. The external validation showed AUC: 0.806, 95% CI: 0.694–0.917, Hosmer–Lemeshow test p = 0.666 and calibration plot coefficient of r = 0.939. Conclusion: A total of 7 maternal-fetal factors were found to be strongly associated with c-section delivery, including gestational age < 37, maternal underweight body mass index, previous uterine surgery, obstetrical complications, birthweight ⩾ 3500, history of vaginal delivery, and non-cephalic presentation. Using these factors, a prediction tool was developed and validated with good quality. © The Author(s) 2021. |
cesarean section; maternal-fetal characteristics; mode of delivery; prediction; scoring system |
7 point scoring system; abdominal circumference; adult; area under the curve; Article; biological activity; birth weight; body mass; cesarean section; clinical examination; cohort analysis; diagnostic test accuracy study; exploratory factor analysis; female; fetus weight; forceps delivery; gestational age; human; major clinical study; maternal fetal characteristics; mortality; myomectomy; non cephalic presentation; obstetrical complication; prediction; pregnancy complication; pregnant woman; prenatal care; questionnaire; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; underweight; urologic surgery; vaginal delivery; obstetric delivery; pregnancy; Cesarean Section; Delivery, Obstetric; Female; Gestational Age; Humans; Pregnan |
SAGE Publications Ltd |
17455057 |
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34818932 |
Article |
Q1 |
1363 |
2670 |
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97 |
Miranda A.V., Wiyono L., Rocha I.C.N., Cedeño T.D.D., Lucero-Prisno D.E., III |
57222664687;57207889054;57223283646;57224097138;56051373800; |
Strengthening virology research in the association of Southeast Asian nations: Preparing for future pandemics |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
5 |
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1141 |
1143 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119604704&doi=10.4269%2fajtmh.21-0589&partnerID=40&md5=98ad7364acccdc95ee57ef0ea9e65ed9 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
Miranda, A.V., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyono, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Cedeño, T.D.D., School of Medicine, Centro Escolar University, Manila, Philippines; Lucero-Prisno, D.E., III, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
The Association of Southeast Asian Nations (ASEAN) region is known to be a global hotspot to viral outbreaks because of many factors. To limit the impact of future outbreaks, it is crucial for the ASEAN governments to strengthen regional virology research capacity. The ASEAN governments have collaborated in several virology initiatives, with the most recent being the establishment of the ASEAN Regional Center for Public Health Emergencies and Emerging Diseases. However, several challenges, including technology disparities, nationalistic tendencies, and the lack of public acceptance toward virus sharing, need to be addressed to maximize the region’s collaboration potential in virology research. We recommend the governments to 1) prioritize the strengthening of research capacities; 2) develop stronger cooperation and possible centralization of efforts on top of national capacities; 3) develop an equitable and secure research framework; and 4) improve the public awareness regarding the importance of regional public health responses. Copyright © 2021 by The American Society of Tropical Medicine and Hygiene |
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epidemic; human; medical research; organization and management; pandemic; Southeast Asia; virology; Asia, Southeastern; Biomedical Research; Disease Outbreaks; Humans; Pandemics; Virology |
American Society of Tropical Medicine and Hygiene |
00029637 |
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34506300 |
Article |
Q1 |
1015 |
4298 |
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98 |
Yusharyahya S.N., Bramono K., Indriatmi W., Prasetyo M., Ascobat P., Hestiantoro A., Wiraguna A.A.G.P. |
57211780941;9843236700;57189888041;57192905252;55795863600;8743255100;20437026700; |
Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
11 |
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95 |
103 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119480025&doi=10.7324%2fJAPS.2021.1101113&partnerID=40&md5=020217cd5f217dbc98ba3162ac9d99f1 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ascobat, P., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiraguna, A.A.G.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Postmenopausal hypoestrogenism is associated with skin aging, for which phytoestrogen derived from the seeds of Trigonella foenum graecum (fenugreek) is expected to be an alternative solution to reduce wrinkles and increase the thickness of postmenopausal women’s skin. This study was a randomized, double-blind, controlled 12-weeks trial conducted at a general hospital in Jakarta, Indonesia, from January to November 2019. Subjects were 50 postmenopausal women divided into two groups: the intervention group was given 5% fenugreek cream and base cream was given to the placebo group. The results of the independent t-test showed that both groups were able to achieve statistically significant improvement in wrinkle scores on the forehead, crow’s feet, and nasolabial folds which was assessed by photography scoring based on Bazin’s skin aging atlas for Asian skin volume 2 but there was no significant disparity between both groups at all time points. Dermal thickness was assessed by high-resolution ultrasound GE LOGIQ E9 (18 MHz), which showed similar results for both groups with significant improvements in the 8th week compared to baseline and a significant decrease by the 12th week. No significant differences were observed in the skin wrinkle score and skin thickness after the application of fenugreek cream compared to placebo.We suspect that a concentration of 5% was not adequate for the expected antiskin aging effects. Further studies are necessary to determine a more appropriate fenugreek concentration to permit clinical use as an antiskin aging therapy in postmenopausal women. © 2021 Shannaz Nadia Yusharyahya et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License |
Dermal thickness; fenugreek; postmenopausal skin; skin wrinkle |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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101 |
Lazarus G., Nelwan E.J., Hamers R.L. |
57214599425;14527452900;23034345900; |
Transaminases and serum albumin as early predictors of severe dengue |
2021 |
The Lancet Infectious Diseases |
21 |
11 |
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1488 |
1489 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117964341&doi=10.1016%2fS1473-3099%2821%2900583-1&partnerID=40&md5=4f1ea8000ad6ebe270b36045aad4f5b7 |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, United Kingdom |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Nelwan, E.J., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamers, R.L., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, United Kingdom |
[No abstract available] |
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aminotransferase; serum albumin; aminotransferase; serum albumin; human; Letter; meta analysis; protein blood level; severe dengue; systematic review (topic); dengue; liver function test; severe dengue; Dengue; Humans; Liver Function Tests; Serum Albumin; Severe Dengue; Transaminases |
Elsevier Ltd |
14733099 |
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34717802 |
Letter |
Q1 |
7475 |
144 |
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109 |
Patelis N., Bisdas T., Jing Z., Feng J., Trenner M., Tri Nugroho N., Ocke Reis P.E., Elkouri S., Lecis A., Karam L., Roux D.L., Ionac M., Berczeli M., Jongkind V., Yeung K.K., Katsargyris A., Avgerinos E., Moris D., Choong A., Ng J.J., Cvjetko I., Antoniou G.A., Ghibu P., Svetlikov A., Pedrajas F.G., Ebben H., Stepak H., Chornuy A., Kostiv S., Ancetti S., Tadayon N., Mekkar A., Magnitskiy L., Fidalgo-Domingos L., Matheiken S., Sarutte Rosello E.S., Isik A., Kirkilesis G., Kakavia K., Georgopoulos S. |
55998488300;33467522500;57262125800;57261537000;56798307500;57211452795;57261833800;6604020673;55309720700;36504221700;57261537100;57262413400;57204192771;22937335300;15926593800;15923092600;6701829526;39661222400;57217303517;57226512691;7801457268;36086125600;57261833900;6508177128;6504474654;56115588600;55760251500;57262413500;57222182796;56703428400;35182045900;57261687200;57262413600;57197759620;36834063300;57261982900;57159146500;56201755100;57191724932;7003934555; |
Vascular e-Learning During the COVID-19 Pandemic: The EL-COVID Survey |
2021 |
Annals of Vascular Surgery |
77 |
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63 |
70 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115056401&doi=10.1016%2fj.avsg.2021.08.001&partnerID=40&md5=f50ec7bdac85163ad44fb75c200c67b8 |
Third Department of Vascular Surgery, Athens Medical Center, Greece; National & Kapodistrian University of Athens, Greece; Vascular surgery department, First affiliated hospital to Navy medical universityShanghai, China; Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; Faculty of Medicine University of Indonesia - Cipto Mangunkusumo National Hospital, Indonesia; Federal University Fluminense, Brazil; Centre Hospitalier de l'Université de Montréal, Canada; Centre Hospitalier de Troyes, France; Hotel Dieu de France Hospital, Lebanon; University of the Witwatersrand, South Africa; University of Medicine and Pharmacy, Romania; Semmelweis University, Hungary; Amsterdam University Medical Center, Netherlands; VU Medical Center, Netherlands; Paracelsus Medical University, Klinikum Nurenberg, Germany; University of Pittsburgh Medical Center, United States; Duke University Medical Center, United States; National University of Singapore, Singapore; University Hospital Merkur, Croatia; Pennine Acute Hospitals NHS TrustUK, United Kingdom; University Hospital HairmyresUK, United Kingdom; Vascular & endovascular surgery Center, National Scientific-Clinical Memorial Hospital, "Professor I.I. Mechnikov", North-Western Medical University, Russian Federation; Hospital Quironsalud Málaga, Spain; Poznan University of Medical Sciences, Poland; Ternopil University Clinic, Ukraine; University of Bologna, Italy; Shahid Beheshti University of Medical Sciences, Iran; CHU Titi Ouzou, Algeria; Pirogov City Hospital No1, Russian Federation; Hospital Clínico Universitario de Valladolid, Spain; Bedford Hospital NHS TrustUK, United Kingdom; Universidad de la Republica, Uruguay; Erzincan Binali Yildirim University, Turkey |
Patelis, N., Third Department of Vascular Surgery, Athens Medical Center, Greece, National & Kapodistrian University of Athens, Greece; Bisdas, T., Third Department of Vascular Surgery, Athens Medical Center, Greece; Jing, Z., Vascular surgery department, First affiliated hospital to Navy medical universityShanghai, China; Feng, J., Vascular surgery department, First affiliated hospital to Navy medical universityShanghai, China; Trenner, M., Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; Tri Nugroho, N., Faculty of Medicine University of Indonesia - Cipto Mangunkusumo National Hospital, Indonesia; Ocke Reis, P.E., Federal University Fluminense, Brazil; Elkouri, S., Centre Hospitalier de l'Université de Montréal, Canada; Lecis, A., Centre Hospitalier de Troyes, France; Karam, L., Hotel Dieu de France Hospital, Lebanon; Roux, D.L., University of the Witwatersrand, South Africa; Ionac, M., University of Medicine and Pharmacy, Romania; Berczeli, M., Semmelweis University, Hungary; Jongkind, V., Amsterdam University Medical Center, Netherlands; Yeung, K.K., VU Medical Center, Netherlands; Katsargyris, A., National & Kapodistrian University of Athens, Greece, Paracelsus Medical University, Klinikum Nurenberg, Germany; Avgerinos, E., National & Kapodistrian University of Athens, Greece, University of Pittsburgh Medical Center, United States; Moris, D., Duke University Medical Center, United States; Choong, A., National University of Singapore, Singapore; Ng, J.J., National University of Singapore, Singapore; Cvjetko, I., University Hospital Merkur, Croatia; Antoniou, G.A., Pennine Acute Hospitals NHS TrustUK, United Kingdom; Ghibu, P., University Hospital HairmyresUK, United Kingdom; Svetlikov, A., Vascular & endovascular surgery Center, National Scientific-Clinical Memorial Hospital, "Professor I.I. Mechnikov", North-Western Medical University, Russian Federation; Pedrajas, F.G., Hospital Quironsalud Málaga, Spain; Ebben, H., Semmelweis University, Hungary; Stepak, H., Poznan University of Medical Sciences, Poland; Chornuy, A., Ternopil University Clinic, Ukraine; Kostiv, S., Ternopil University Clinic, Ukraine; Ancetti, S., University of Bologna, Italy; Tadayon, N., Shahid Beheshti University of Medical Sciences, Iran; Mekkar, A., CHU Titi Ouzou, Algeria; Magnitskiy, L., Pirogov City Hospital No1, Russian Federation; Fidalgo-Domingos, L., Hospital Clínico Universitario de Valladolid, Spain; Matheiken, S., Bedford Hospital NHS TrustUK, United Kingdom; Sarutte Rosello, E.S., Universidad de la Republica, Uruguay; Isik, A., Erzincan Binali Yildirim University, Turkey; Kirkilesis, G., National & Kapodistrian University of Athens, Greece; Kakavia, K., National & Kapodistrian University of Athens, Greece; Georgopoulos, S., National & Kapodistrian University of Athens, Greece |
Background: The corona virus disease (COVID-19) pandemic has radically changed the possibilities for vascular surgeons and trainees to exchange knowledge and experience. The aim of the present survey is to inventorize the e-learning needs of vascular surgeons and trainees as well as the strengths and weaknesses of vascular e-Learning. Methods: An online survey consisting of 18 questions was created in English, with a separate bilingual English-Mandarin version. The survey was dispersed to vascular surgeons and trainees worldwide through social media and via direct messaging from June 15, 2020 to October 15, 2020. Results: Eight hundred and fifty-six records from 84 different countries could be included. Most participants attended several online activities (>4: n = 461, 54%; 2–4: n = 300, 35%; 1: n = 95, 11%) and evaluated online activities as positive or very positive (84.7%). In deciding upon participation, the topic of the activity was most important (n = 440, 51.4%), followed by the reputation of the presenter or the panel (n = 178, 20.8%), but not necessarily receiving accreditation or certification (n = 52, 6.1%). The survey identified several shortcomings in vascular e-Learning during the pandemic: limited possibility to attend due to lack of time and increased workload (n = 432, 50.5%), no protected/allocated time (n = 488, 57%) and no accreditation or certification, while technical shortcomings were only a minor problem (n = 25, 2.9%). Conclusions: During the COVID-19 pandemic vascular e-Learning has been used frequently and was appreciated by vascular professionals from around the globe. The survey identified strengths and weaknesses in current e-Learning that can be used to further improve online learning in vascular surgery. © 2021 |
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accreditation; Article; certification; controlled study; coronavirus disease 2019; distance learning; e-learning; English (language); geographic distribution; health survey; human; information dissemination; Internet; Mandarin (language); pandemic; social media; surgical training; vascular surgeon; vascular surgery; workload; workplace; clinical trial; comorbidity; education; follow up; learning; medical education; multicenter study; pandemic; procedures; questionnaire; retrospective study; surgery; teaching; vascular disease; vascular surgery; Comorbidity; Computer-Assisted Instruction; COVID-19; Education, Medical, Graduate; Follow-Up Studies; Humans; Learning; Pandemics; Retrospective Studies; SARS-CoV-2; Specialties, Surgical; Surveys and Questionnaires; Vascular Diseases; Vascular Sur |
Elsevier Inc. |
08905096 |
|
34478845 |
Article |
Q2 |
635 |
7940 |
|
|
|
110 |
Abdullah M., Sukartini N., Nursyirwan S.A., Pribadi R.R., Maulahela H., Utari A.P., Muzellina V.N., Wiraatmadja A., Renaldi K. |
7103393434;6505680329;57249143800;57194732282;57189612709;57113585900;57223968527;57249709700;57190963547; |
Gut Microbiota Profiles in Early-and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future |
2021 |
Digestion |
102 |
6 |
|
823 |
832 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114428104&doi=10.1159%2f000516689&partnerID=40&md5=b8c0c7b633dbb180aa40d5f20e5481d7 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Abdullah, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sukartini, N., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pribadi, R.R., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Utari, A.P., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Muzellina, V.N., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Wiraatmadja, A., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Renaldi, K., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background: Researchers believe the role of gut microbiota dysbiosis in the raised incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be associated with microbiota dysbiosis either dependently or independently (combined with other risk factors). Summary: Recently, the rising of incidence and mortality of EOCRC have been noted. Some researchers are looking for risk factors influencing this fact. They hypothesize that it may be because of microbiota dysbiosis. Microbiota dysbiosis has been known to promote cancer development through immunity dysregulation and chronic inflammation. Microbiomes profile in late-onset colorectal cancer (LOCRC) among older patients has been documented, but there is still lack of data about microbial profiles among younger colorectal cancer (CRC) patients. This review tries to explain microbial profiles differences between EOCRC and LOCRC as a potential diagnostic biomarker in the future, and whether microbiota can have a role in EOCRC genesis. Key Messages: Microbiota does vary with age, and EOCRC may be associated with colonization of some specific bacteria. Further studies about gut microbiota profiles in EOCRC and LOCRC may provide a new insight on diagnostic biomarker of CRC. © 2021 S. Karger AG, Basel. Copyright: All rights reserved. |
Colorectal cancer; Diagnostic biomarker; Early-onset colorectal cancer; Gut microbiota; Microbiota dysbiosis |
biological marker; colorectal tumor; dysbiosis; human; incidence; intestine flora; Biomarkers; Colorectal Neoplasms; Dysbiosis; Gastrointestinal Microbiome; Humans; Incidence |
S. Karger AG |
00122823 |
|
34433172 |
Review |
Q2 |
882 |
5279 |
|
|
|
112 |
Ong J., Ong A.M.L., Ong S., Xin X., Lee Y.Y., Pausawasdi N., De Lusong M.A., Makmun D., Chong V.H., Ho S.H., Lim W., Ong D., Dan Y.Y., Khor C. |
57193716100;36942342000;35741447900;57326122500;56191149300;6602327609;23767987600;16638046900;54790563600;50561284200;57194415809;56013316700;8699022400;8549610200; |
The impact of the coronavirus disease 2019 pandemic on gastroenterologists in Southeast Asia: A mixed-methods study |
2021 |
Journal of Gastroenterology and Hepatology (Australia) |
36 |
11 |
|
3056 |
3068 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112680822&doi=10.1111%2fjgh.15594&partnerID=40&md5=3c1bb0505aa3a502aa7cea4abadd518a |
Department of Medicine, National University of Singapore, Singapore; Department of Engineering, University of Cambridge, Cambridge, United Kingdom; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore; Department of Surgical Intensive Care, Singapore General Hospital, Singapore; Department of Anaesthesiology, Sengkang General Hospital, Singapore; Health Services Research Unit, Singapore General Hospital, Singapore; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia; GI Function and Motility Unit, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia; Division of Gastroenterology, Department of Medicine, Mahidol University Faculty of Medicine at Siriraj Hospital, Bangkok, Thailand; Section of Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Philippine General Hospital, Manila, Philippines; Faculty of Medicine, Division of Gastroenterology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Gastroenterology Unit, Department of Medicine, RIPAS Hospital, Bandar Seri Begawan, Brunei Darussalam; Institute of Health Sciences, PAPRSB Universiti of Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam; Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Anaesthesiology, Singapore General Hospital, Singapore; Department of Medicine, Division of Gastroenterology and Hepatology, National University Hospital, Singapore |
Ong, J., Department of Medicine, National University of Singapore, Singapore, Department of Engineering, University of Cambridge, Cambridge, United Kingdom; Ong, A.M.L., Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Duke-NUS Medical School, Singapore; Ong, S., Department of Surgical Intensive Care, Singapore General Hospital, Singapore, Department of Anaesthesiology, Sengkang General Hospital, Singapore; Xin, X., Health Services Research Unit, Singapore General Hospital, Singapore; Lee, Y.Y., School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia, GI Function and Motility Unit, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia; Pausawasdi, N., Division of Gastroenterology, Department of Medicine, Mahidol University Faculty of Medicine at Siriraj Hospital, Bangkok, Thailand; De Lusong, M.A., Section of Advanced Endoscopy, Division of Gastroenterology, Department of Medicine, Philippine General Hospital, Manila, Philippines; Makmun, D., Faculty of Medicine, Division of Gastroenterology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Chong, V.H., Gastroenterology Unit, Department of Medicine, RIPAS Hospital, Bandar Seri Begawan, Brunei Darussalam, Institute of Health Sciences, PAPRSB Universiti of Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam; Ho, S.H., Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Lim, W., Department of Anaesthesiology, Sengkang General Hospital, Singapore, Department of Anaesthesiology, Singapore General Hospital, Singapore; Ong, D., Department of Medicine, Division of Gastroenterology and Hepatology, National University Hospital, Singapore; Dan, Y.Y., Department of Medicine, National University of Singapore, Singapore, Department of Medicine, Division of Gastroenterology and Hepatology, National University Hospital, Singapore; Khor, C., Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Duke-NUS Medical School, Singapore |
Background and Aim: The coronavirus disease 2019 pandemic has impacted gastroenterology practices worldwide; however, its protracted effects within Southeast Asia were unknown. The primary aim of the study was to determine the impact of the pandemic on clinical demands including burnout among gastroenterologists within the region. The secondary aim was to identify risk factors for burnout and determine regional stressors. Methods: This was a mixed-methods study. Gastroenterologists were surveyed electronically between September 1 and December 7, 2020, via gastroenterology and endoscopy societies of Brunei, Indonesia, Malaysia, Philippines, Singapore, and Thailand. Quantitative and qualitative data were collected. The 22-item Maslach Burnout Inventory-Human Services Survey (MBI-HSS) was used to detect burnout. Quantitative data were non-parametric; non-parametric methods were used for statistical comparisons. Logistic regression was used to determine risk factors for burnout. Content analysis method was used to analyze qualitative data. Ethical approval was obtained. Results: A total of 73.0% reported that they were still significantly affected by the pandemic. Of these, 40.5% reported increased workload and 59.5% decreased workload. Statistically significant differences in weekly working hours, endoscopy, and inpatient volumes were present. No differences were observed in outpatient volumes, likely because of telemedicine. Burnout was common; however, 50.1% of gastroenterologists were unaware of or did not have access to mental health support. This, as well as depression, being a trainee, and public sector work, increased burnout risk significantly. Conclusion: The effects of the pandemic are multifaceted, and burnout is common among Southeast Asian gastroenterologists. Safeguards for mental health are suboptimal, and improvements are urgently needed. © 2021 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
burnout; COVID-19; gastroenterologists; gastroenterology; pandemic |
adult; Article; Brunei Darussalam; content analysis; controlled study; coronavirus disease 2019; data collection method; depression; endoscopy; female; gastroenterologist; hospital patient; human; Indonesia; job stress; logistic regression analysis; major clinical study; Malaysia; male; Maslach Burnout Inventory-Human Services Survey; mental health; multicenter study; nonparametric test; pandemic; Philippines; professional burnout; public sector; qualitative research; quantitative analysis; risk factor; Singapore; Southeast Asia; telemedicine; Thailand; workload; burnout; epidemiology; gastroenterologist; middle aged; pandemic; psychology; questionnaire; Adult; Asia, Southeastern; Burnout, Professional; COVID-19; Female; Gastroenterologists; Humans; Male; Middle Aged; Pandemics; SARS-CoV-2 |
John Wiley and Sons Inc |
08159319 |
|
34159640 |
Article |
Q1 |
1214 |
3242 |
|
|
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116 |
Munadzilah S., Hegar B., Sekartini R., Vandenplas Y. |
57346126700;6506273944;57224503576;57223670656; |
Association between milk consumption and lactose malabsorption in Indonesian children |
2021 |
Chinese Journal of Contemporary Pediatrics |
23 |
10 |
|
975 |
980 |
|
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119440135&doi=10.7499%2fj.issn.1008-8830.2105030&partnerID=40&md5=80626db7ac7feaae0925a1057b4f77eb |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kidz Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium |
Munadzilah, S., Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hegar, B., Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekartini, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Vandenplas, Y., Kidz Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium |
Objective To study the association between milk consumption and lactose malabsorption in Indonesian children aged 3-12 years. Methods This cross sectional study was conducted in randomly selected presumed healthy children with good nutritional status aged 3-12 years in Central Jakarta, Indonesia (n=174), including 72 children aged 3-5 years and 102 children aged 6-12 years. Results The prevalence of lactose malabsorption in children aged 3-5 years and children aged 6-12 years was 20.8% (15/72) and 35.3% (36/102), respectively. There was no association between milk or milk product consumption and lactose malabsorption (P>0.05). In the 51 children with lactose malabsorption, the predominant clinical symptoms were diarrhea (62%), abdominal pain (52%), and nausea (5%) during the hydrogen breath test. Conclusions There is no association between milk consumption and lactose malabsorption in Indonesian children aged 3-12 years, suggesting that genetic predisposition may be more important than adaptive mechanisms to lactose consumption. © 2021 Xiangya Hospital of CSU. All rights reserved. |
Child; Hydrogen breath test; Lactose malabsorption; Milk consumption; Prevalence |
abdominal pain; adult; Article; child; cross-sectional study; dairy product; diarrhea; disease association; female; genetic predisposition; human; hydrogen breath test; lactose intolerance; male; milk; nausea; prevalence; animal; breath analysis; Indonesia; lactose intolerance; milk; Animals; Breath Tests; Child; Cross-Sectional Studies; Humans; Indonesia; Lactose Intolerance; Milk |
Central South University |
10088830 |
|
34719410 |
Article |
Q3 |
174 |
21112 |
|
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