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Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Art No	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Publisher	Issn	Isbn	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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194	Mansyur M.	37085506800;	Occupational health, productivity and evidence-based workplace health intervention	2021	Acta Medica Philippina	55	6		602	603		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116680924&doi=10.47895%2fAMP.V55I6.4273&partnerID=40&md5=e8cf11e83c91edd4e2dccb08e749b070	Department of Community Medicine, Faculty of Medicine, Universitas Indonesia	Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia	[No abstract available]		University of the Philippines Manila	00016071		Editorial	Q4	128	25603	View
195	Habiburrahman M., Lesmana E., Harmen F., Gratia N., Mirtha L.T.	57320844200;57208440285;57288593800;57288763400;57193201450;	The impact of sleep deprivation on work performance towards night-shift healthcare workers: An evidence-based case report	2021	Acta Medica Philippina	55	6		650	664		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116676334&doi=10.47895%2fAMP.V55I6.3157&partnerID=40&md5=279c9c6f812ba7d9e6cf09363847268d	Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hospital of Universitas Indonesia, Depok, Indonesia	Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lesmana, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harmen, F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gratia, N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mirtha, L.T., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Hospital of Universitas Indonesia, Depok, Indonesia	Background. Poor sleep and excessive fatigue among workers can reduce well-being and physical fitness. However, not many studies have mentioned how sleeping deprivation among night-shift healthcare workers impacted their work performance in multiple aspects. Method. We conducted an evidence-based case report (EBCR) of a night shift nurse who was worried about the impact of her sleep deprivation on her work performance in the future due to prior history of needle-stick injuries. We aimed to determine whether sleeping deprivation caused by regular night shifts leads to decreased work performance among night-shift healthcare workers by formulating a clinical question. Evidence was searched systematically using five major journal databases (Proquest, EBSCO-Host, PubMed, ScienceDirect, and Cochrane) and was assessed thoroughly using inclusion and exclusion criteria. Results. Eleven eligible studies were obtained with a medium level of evidence (III-IV), three systematic reviews with meta-analyses (SR-MA), three SR without MA, and five observational studies. All of them were analyzed and critically appraised using Oxford Evidence-Based Medicine and Joanna Briggs Institute tools. We found that reduced quantity and quality of sleep impacted all dimensions of work performance among healthcare professionals, be it in task performance (e.g., skill proficiency), contextual performance (e.g., communication skill and mental health issues), and patient and health worker safety (accident and medication error). It could also encourage counterproductive work behavior, such as absenteeism. Furthermore, sleep deprivation changes circadian rhythms, causing decreased information processing and affective recognition functions in some vital brain areas, ultimately affecting several work dimensions. Conclusion. In conclusion, stakeholders need to adjust proper shift scheduling for health care workers, practice sleep hygiene, maintain physical fitness, and consume nutritional food, positively correlated to health and productivity. © 2021 University of the Philippines Manila. All rights reserved.	Evidence-based medicine; Healthcare worker; Night shift; Sleep deprivation; Work performance	University of the Philippines Manila	00016071		Article	Q4	128	25603	View
196	Alie I.R., Andriantoro H., Timan I.S., Sulistomo A.W., Illyas E.I., Mansyur M.	57288933200;55037171500;6602793366;57024018500;57288423500;37085506800;	Potency biomarker effect of endothelial microparticles (emps) for early prediction of cardiovascular risk in shift worker nurses	2021	Acta Medica Philippina	55	6		616	620		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116671512&doi=10.47895%2fAMP.V55I6.3142&partnerID=40&md5=10ceaf9c58aabc0ce93083d831644fe1	Program of Universitas Indonesia; Department of Cardiology and Vascular Faculty of Medicine, Universitas Indonesia; Department of Pathology Clinic, Faculty of Medicine, Universitas Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia; Department of Physiology, Faculty of Medicine, Universitas Indonesia	Alie, I.R., Program of Universitas Indonesia; Andriantoro, H., Department of Cardiology and Vascular Faculty of Medicine, Universitas Indonesia; Timan, I.S., Department of Pathology Clinic, Faculty of Medicine, Universitas Indonesia; Sulistomo, A.W., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia; Illyas, E.I., Department of Physiology, Faculty of Medicine, Universitas Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia	Objectives. Shift work results in changing worker's behavior, food, and sleep patterns, which can cause circadian rhythm disturbance, which is a cardiovascular risk. Until now, a biomarker of early prediction of cardiovascular risk on shift workers is still not developed. This study aimed to assess the cardiovascular risk of shift worker nurses by detecting endothelial microparticles (EMPs). Methods. This longitudinal study compared six shift nurses and five non-shift nurses by measuring the EMPs using antigen CD31+ flow cytometry. All met the inclusion criteria consisting of 28 blood samples followed in one week shift. Results. EMPs among non-shift nurses were below 200 μL. However, shift nurses' EMPs increased above 200 μL with Man-Whitney U p = 0.000 on days 4 and 7 following a one shift per week schedule. Conclusion. There was an increase in shift workers' endothelial microparticles (EMP) which was a sign of cardiovascular risk. © 2021 University of the Philippines Manila. All rights reserved.	Cardiovascular risk; CD31+; Endothelial microparticles (EMPs); Nurse; Shift work	University of the Philippines Manila	00016071		Article	Q4	128	25603	View
198	Kartika R.W., Alwi I., Yunir E., Waspadji S., Suyatna F.D., Bardosono S., Immanuel S., Sungkar S., Rachmat J., Silalahi T., Reksodiputro M.H.	57223447932;15055173800;36520254800;8678136400;56039633100;21933841000;57272979000;57016857300;6507225348;56275255400;35090488800;	Efficacy of Combining Hyaluronic Acid and Platelet-Rich Fibrin in Diabetic Foot Ulcer	2021	Jordan Journal of Biological Sciences	14	3		607	611	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115791952&partnerID=40&md5=76c1dc1bbdde331f901d412f6b6a83ba	Doctoral Program in Medical Science Faculty of Medicine Universitas Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine Krida Wacana Christian University, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Indonesia; Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Jakarta, Indonesia; Department of Otorhinolaryngology, Facial Plastic Reconstructive Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Kartika, R.W., Doctoral Program in Medical Science Faculty of Medicine Universitas Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine Krida Wacana Christian University, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Indonesia; Bardosono, S., Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sungkar, S., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Jakarta, Indonesia; Reksodiputro, M.H., Department of Otorhinolaryngology, Facial Plastic Reconstructive Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Objectives: A chronic complication of type-2 diabetes mellitus (DMT-2) is Diabetic Foot Ulcer (DFU). The main treatment used in DFU is wound cleansing, followed by dressing the wound as a local control to increase tissue granulation and epithelialization. This study aims to compare the efficacy of the combination of Hyaluronic Acid with Platelet Rich Fibrin (HAPRF) and Platelet Rich Fibrin alone in DFU. Methods: We conducted a randomized controlled trial from July 2019 to April 2020. The study was approved by the Ethics Committee of the Faculty of Medicine of Universitas Indonesia ID 0855 / UN2.F1 / ETIK / 2018. Informed consent was obtained from the patients. This was a randomized clinical study to compare the efficacy of HAPRF and PRF in DFU one week post debridement. Twenty DFU samples were collected divided into 2 treatment groups: topical treatment using HAPRF compare with PRF alone. Assessment for wounds improvement was recorded using a digital camera 48 mega pixel with an accuracy of 0.1% on day-0, 3, 7, and 14. The results of the wound photographs were processed using ImageJ software. The granulation area (GA) and wound area (WA) were evaluated by IBM SPSS software v.20. The general data description was presented in median (range) value and parameter’s differences were conducted using Mann–Whitney test Results: The two treatment groups showed insignificant difference in characteristics between both group before intervention. The mean granulation width after two weeks of use HAPRF was 97.4% and PRF was 81.9%. Statistical analysis using Mann Whitney test showed granulation area of HAPRF group was significantly different compared with PRF group on day-3(p=0.047), day-7 ( p = 0.004) and day-14 ( p < 0.001). At the end of the wound healing process, the HAPRF group was significantly different compared with PRF group on Δ day 0−3 ( p=0.048), Δ day 0−7 ( p = 0.039), and Δ day 0−14 ( p = 0.023). Conclusions: HAPRF improves wound healing rate through increasing granulation tissue and epithelialization compared with PRF only in diabetic foot ulcer after 2 weeks post debridement compared to PRF. © 2021, Jordan Journal of Biological Sciences. All Rights Reserved.	Delta Wound Area; Diabetic ulcer; Granulation Area; Hyaluronic Acid; Platelet Rich Fibrin	Hashemite University	19956673		Article	Q3	216	18398	View
199	Tunjungputri R.N., Tetrasiwi E.N., Veronica M., Pandelaki J., Ibrahim F., Nelwan E.J.	56342194400;57267704700;57268337000;35759266900;57226400046;14527452900;	Vaccine-associated disease enhancement: a case report of post-vaccination COVID-19	2021	International Journal of Antimicrobial Agents	58		21003575				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115401929&doi=10.1016%2fj.ijantimicag.2021.106421.86&partnerID=40&md5=46457ba71f5610aae7b204755fcef50d	Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Infectious Disease and Immunology Research Center—IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Tunjungputri, R.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tetrasiwi, E.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Veronica, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ibrahim, F., Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Infectious Disease and Immunology Research Center—IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	[No abstract available]		Elsevier B.V.	09248579		Article	Q1	1454	2387	View
200	Fadrian F., Nelwan E.J., Kurniawan J., Pohan H.T.	57268114000;14527452900;57193251655;23474782900;	Risk of infection with multiple pathogen in post liver transplantation patient in referral centre in Jakarta, Indonesia	2021	International Journal of Antimicrobial Agents	58		21003320				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115366248&doi=10.1016%2fj.ijantimicag.2021.106421.61&partnerID=40&md5=e23afb1d78408e73580d689f6327bb02	Department of Internal Medicine;; Division of Tropical and Infectious Disease;; Division of Hepatology Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia	Fadrian, F., Department of Internal Medicine;; Nelwan, E.J., Department of Internal Medicine;, Division of Tropical and Infectious Disease;; Kurniawan, J., Department of Internal Medicine;, Division of Hepatology Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Pohan, H.T., Department of Internal Medicine;, Division of Tropical and Infectious Disease;	[No abstract available]	aspergillosis.; biloma; CMV; post liver transplantation infection	Elsevier B.V.	09248579		Article	Q1	1454	2387	View
201	Tunjungputri R.N., Tetrasiwi E.N., Rizqa T., Mulansari N.A., Harimurti K.	56342194400;57267704700;57268337300;36519326000;23473513200;	Parenteral and oral anticoagulant treatment for hospitalized and post-discharge patients with COVID-19: A systematic review	2021	International Journal of Antimicrobial Agents	58		21003587				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115349747&doi=10.1016%2fj.ijantimicag.2021.106421.87&partnerID=40&md5=c258c13fa4bd248528cd36e04d4d4fd4	Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Division of Hematology and Medical Oncology, Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital	Tunjungputri, R.N., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Tetrasiwi, E.N., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Rizqa, T., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Mulansari, N.A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital; Harimurti, K., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;	[No abstract available]	anticoagulant; COVID-19; thromboprophylaxis.; VTE	Elsevier B.V.	09248579		Article	Q1	1454	2387	View
204	Heltty H., Sitorus R., Martha E., Nusdwinuringtyas N.	57262112500;57194329674;55841280100;56608215500;	Experience of the patient's success in facing post-stroke urinary incontinence: The patient's perspective	2021	Frontiers of Nursing	8	3		291	301	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115061619&doi=10.2478%2ffon-2021-0030&partnerID=40&md5=9c066e6d2b1fc65cd5adc1fc8034247d	Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia	Heltty, H., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Sitorus, R., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Martha, E., Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Nusdwinuringtyas, N., Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia	Objective: Post-stroke urinary incontinence (UI) is one of the sequelae of stroke. This situation affects all aspects of the patient's life - physically, psychologically, socially, and spiritually. This study aimed to investigate the experience of patients' success in facing a post-stroke UI. Methods: A qualitative study using the Rapid Assessment Procedure (RAP) approach was used in this study. Informants were selected using purposive sampling. In-depth interviews with as many as 8 patients who had recovered from post-stroke UI and living in the greater area of Southeast Sulawesi (Indonesia) were conducted. In-depth interviews were also conducted with 8 caregivers and 2 nurses. Data were analyzed using a thematic analysis approach and interpretation of data was based on Humanbecoming theory and Self-care deficit theory of nursing. Results: Five successful things the patients experienced during post-stroke UI were identified. The five successes were as follows: they provided information to get to know and understand post-stroke UI, followed the procedures to overcome post-stroke UI, conducted self-control exercises and stayed motivated, performed daily activities independently according to ability, and made use of family support and peers' attention. Conclusions: These findings indicated that persistence, belief, independence, and social support (family and peer) made patients to successfully face their post-stroke UI and improved their quality of life. These findings also became the basis for developing a post-stroke UI management model based on Humanbecoming theory and Self-care deficit theory of nursing. © 2021 Heltty Heltty et al., published by Sciendo.	experience of patient's success; patient's perspective; post-stroke urinary incontinence	Sciendo	25448994		Review	Q4	152	22962	View
205	Krisanti E.A., Gofara T.Z., Rahyussalim A.J., Mulia K.	14019920500;57260804700;55212166100;6507666535;	Polyvinyl alcohol (PVA)/chitosan/sodium tripolyphosphate (STPP) hydrogel formulation with freeze-thaw method for anti-tuberculosis drugs extended release	2021	AIP Conference Proceedings	2370		020010				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115001335&doi=10.1063%2f5.0063175&partnerID=40&md5=a3c9afce6e9d9f6305976a87eb3a4790	Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia	Krisanti, E.A., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Gofara, T.Z., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Rahyussalim, A.J., Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Mulia, K., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia	Tuberculosis (TB) is one of the infectious diseases which must be routinely oral treated with anti-tuberculosis drugs performed 12-24 months. With treatment using drug implans that can release TB drugs in a longer time in the target location, it will be more effective, because the drug will be close to the target and go directly into the blood. In this study, the PVA / chitosan / STPP hydrogel formulation loaded with 4 types of anti-tuberculosis drugs (isoniazid, ethambutol, pirazinamide, and rifampicin) made using the freeze-thaw method. It is obtained that chitosan addition up until 20% could reduce drug's release rate and hold drug's release until 30 days, but the effect of STPP addition could not be seen because the ammount added is too small which is also shown from FTIR study that there is no STPP in the hydrogel detected. 80% PVA-20% Chitosan- 2% STPP hydrogel formulation release TB drugs the slowest and extended on Isoniazid, Ethambutol, and Rifampicin. SEM study shown that chitosan addition in PVA hydrogel resulted a homogen solution, and hydrogel with densely folded surface. 2% STPP addition resulted in smoother, more homogenous, and smaller pores morphology. © 2021 Author(s).		American Institute of Physics Inc.	0094243X	9780735441262	Conference Paper	-	177	20880	View
210	Nurhayati R.W., Cahyo R.D., Pratama G., Anggraini D., Mubarok W., Kobayashi M., Antarianto R.D.	55748436600;57212460506;57195959221;57221606578;57208440063;20835016200;57190862806;	Alginate-chitosan microencapsulated cells for improving cd34+ progenitor maintenance and expansion	2021	Applied Sciences (Switzerland)	11	17	7887				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114106674&doi=10.3390%2fapp11177887&partnerID=40&md5=8aa18a5d52c69e6eb72dcb38252f4489	Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia; Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia; Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia	Nurhayati, R.W., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia, Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Cahyo, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Pratama, G., Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia, Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Anggraini, D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Mubarok, W., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Kobayashi, M., Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Antarianto, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia	Protocols for isolation, characterization, and transplantation of hematopoietic stem cells (HSCs) have been well established. However, difficulty in finding human leucocyte antigens (HLA)-matched donors and scarcity of HSCs are still the major obstacles of allogeneic transplanta-tion. In this study, we developed a double-layered microcapsule to deliver paracrine factors from non-matched or low-matched HSCs to other cells. The umbilical cord blood-derived hematopoietic progenitor cells, identified as CD34+ cells, were entrapped in alginate polymer and further protected by chitosan coating. The microcapsules showed no toxicity for surrounding CD34+ cells. When CD34+ cells-loaded microcapsules were co-cultured with bare CD34+ cells that have been collected from unrelated donors, the microcapsules affected surrounding cells and increased the percentage of CD34+ cell population. This study is the first to report the potency of alginate-chitosan microcap-sules containing non-HLA-matched cells for improving proliferation and progenitor maintenance of CD34+ cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.	Alginate; CD34; Chitosan; Hematopoietic; Megakaryocyte; Microencapsulation; Progenitor; Proliferation; Stem cells	MDPI	20763417		Article	Q2	435	11324	View

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