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Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Pubmed Id	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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Asian Pacific Organization for Cancer Prevention(5)
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352	Kristin E., Endarti D., Khoe L.C., Taroeno-Hariadi K.W., Trijayanti C., Armansyah A., Sastroasmoro S.	6504458442;56626162000;56586245200;37012289000;57203727260;57225098604;6507794136;	Economic Evaluation of Adding Bevacizumab to Chemotherapy for Metastatic Colorectal Cancer (mCRC) Patients in Indonesia	2021	Asian Pacific Journal of Cancer Prevention	22	6	1921	1926		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109162811&doi=10.31557%2fAPJCP.2021.22.6.1921&partnerID=40&md5=8b230f77f7dbd1e3652b63db9226b4c0	Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Respira Hospital, Yogyakarta, Indonesia; Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Endarti, D., Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taroeno-Hariadi, K.W., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Trijayanti, C., Respira Hospital, Yogyakarta, Indonesia; Armansyah, A., Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Sastroasmoro, S., Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Objective: Since 2016, bevacizumab has been widely used to treat metastatic colorectal cancer (mCRC) in Indonesia. Nevertheless, the high cost of bevacizumab has raised the question of whether the therapy is considered cost-effective and should be included in the national health insurance system. This study aimed to assess the cost-effectiveness of bevacizumab plus chemotherapy versus chemotherapy alone for the treatment of mCRC patients. Methods: A Markov model was applied using the perspective of the Indonesian healthcare system to assess cost-effectiveness. The health outcomes were expressed in terms of quality-adjusted life years (QALY) using the validated EuroQoL-5D-5L instrument. Data for medical costs were collected from hospital billings in four hospitals located in three different cities in Indonesia. Meanwhile, data for utility were obtained from interviewing 90 patients who came to the hospital. We compared those mCRC patients who received chemotherapy alone either with FOLFOX or FOLFIRI, versus patients who received the addition of bevacizumab. Results: With the perspective of societal, the incremental cost-effectiveness ratio (ICER) of adding bevacizumab was USD 49,312 per QALY gained using secondary data and USD 28,446 per QALY using real world data. Conclusion: Using either a healthcare or societal perspective, the addition of bevacizumab for mCRC treatment was considered not cost-effective. © 2021. All Rights Reserved.	Metastatic colorectal cancer- bevacizumab- chemotherapy	antineoplastic agent; bevacizumab; camptothecin; fluorouracil; folinic acid; platinum complex; colorectal tumor; cost benefit analysis; economics; human; Indonesia; Markov chain; metastasis; pathology; quality adjusted life year; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Cost-Benefit Analysis; Fluorouracil; Humans; Indonesia; Leucovorin; Markov Chains; Neoplasm Metastasis; Organoplatinum Compounds; Quality-Adjusted Life Years	Asian Pacific Organization for Cancer Prevention	15137368	34181352	Article	Q2	512	9866	View
674	Sobri F.B., Bachtiar A., Panigoro S.S., Ayuningtyas D., Gustada H., Yuswar P.W., Nur A.A., Putri R.C.R.A., Widihidayati A.D.	57217500979;56683183900;56790104300;56461361200;57195940157;57253490900;57328088400;57328181200;57328088500;	Factors Affecting Delayed Presentation and Diagnosis of Breast Cancer in Asian Developing Countries Women: A Systematic Review	2021	Asian Pacific Journal of Cancer Prevention	22	10	3081	3092	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118798481&doi=10.31557%2fAPJCP.2021.22.10.3081&partnerID=40&md5=6febc7b64c7dfeddec8aeff299b230ac	Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pondok Indah Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia	Sobri, F.B., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Bachtiar, A., Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Panigoro, S.S., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ayuningtyas, D., Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Gustada, H., Pondok Indah Hospital, Jakarta, Indonesia; Yuswar, P.W., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nur, A.A., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Putri, R.C.R.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Widihidayati, A.D., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia	Background: Advance in screening strategies and management had steadily decreased the mortality rates of breast cancer. In developing countries, conducting screening and early diagnosis of breast cancers may face several problems. This systematic review aims to determine factors affecting the delayed diagnosis of breast cancer in developing countries in Asia. Methods: Literature research was conducted through Pubmed, ScienceDirect, Scopus, EbscoHost, Cochrane Library, and Google Scholar. The main keywords were “breast cancer”, “delayed diagnosis” and “developing countries”. Both quantitative and qualitative studies were included. Results: A total of 26 studies were included. The definition of delayed presentation or diagnosis varied from 1 month to 6 months. Among all the factors from patients and providers, breast symptoms and examinations consistently showed a significant contribution in reducing delayed diagnosis. Strengthened by qualitative studies, patients’ knowledge and perception also had a major role in delayed diagnosis. Conclusion: Among Asian developing countries, breast symptoms and examination, as well as individual knowledge and perception, are the main factors related to delayed diagnosis of breast cancer. © 2021. All Rights Reserved.	Asian developing countries; breast cancer; delayed diagnosis; delayed presentation; examination; knowledge	Asia; Asian; attitude to health; breast tumor; delayed diagnosis; developing country; female; human; symptom assessment; time factor; Asia; Asians; Breast Neoplasms; Delayed Diagnosis; Developing Countries; Female; Health Knowledge, Attitudes, Practice; Humans; Symptom Assessment; Time Factors	Asian Pacific Organization for Cancer Prevention	15137368	34710982	Article	Q2	512	9866	View
675	Anton J., Sudibio S., Handoko H., Permata T.B.M., Kodrat H., Nuryadi E., Sofyan H., Susanto E., Mulyadi R., Aman R.A., Gondhowiardjo S.	57328462500;57283461500;57204105168;57197808751;57210639849;57197806814;57328366500;57204423225;56403164500;36848942500;6508327402;	Overexpression of c-Met is Associated with Poor Prognosis in Glioblastoma Multiforme: A Systematic Review and Meta-Analyses	2021	Asian Pacific Journal of Cancer Prevention	22	10	3075	3080		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118768203&doi=10.31557%2fAPJCP.2021.22.10.3075&partnerID=40&md5=1f49d5bfee87f5293659fdc801e6d63a	Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Anton, J., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudibio, S., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handoko, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sofyan, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Susanto, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mulyadi, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aman, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Objective: The aim of this study is to evaluate the association of c-Met overexpression with survival of glioblastoma multiforme (GBM) patients. Methods: A systematic review with meta-analyses was conducted on related articles from PubMed, EBSCOhost, Scopus, and Cochrane databases with last updated search on October 31, 2020. A total of 7 studies regarding c-Met overexpression and overall survival (OS) and/or progression free survival (PFS) are included in this study. Results: All studies used immunohistochemistry to examine the expression of c-Met protein. The results showed that the positive rate of c-Met overexpression was detected in approximately 33,9% - 60,5% of GBM patients. c-Met overexpression was related to worse OS (HR: 1,74; 95% CI: 1,482-2,043; Z=6,756; p<0,001) and PFS (HR: 1,66; 95% CI: 1,327-2,066; Z=4,464; p<0,001) in GBM patients. Low heterogeneity of subjects was found in both OS and PFS analyses, I2 values were 7,8% and 0,0%, respectively. Conclusion: In conclusion, c-Met overexpression is significantly related to shorter OS and PFS in GBM patients, so c-Met can be considered as a potential prognostic indicator in GBM. © 2021. All Rights Reserved.	c-Met; glioblastoma multiforme; prognosis; survival	MET protein, human; scatter factor receptor; brain tumor; glioblastoma; human; Kaplan Meier method; meta analysis; metabolism; mortality; prognosis; Brain Neoplasms; Glioblastoma; Humans; Kaplan-Meier Estimate; Prognosis; Progression-Free Survival; Proto-Oncogene Proteins c-met	Asian Pacific Organization for Cancer Prevention	15137368	34710981	Article	Q2	512	9866	View
860	Wuyung P.E., Rahadiati F.B., Tjahjadi H., Salinah S., Kusmardi K., Kodariah R., Wiweko B.	57192889605;57222312428;57210953454;57222311659;56966625300;14010667100;43061741400;	Histopathology and Arid1a Expression in Endometriosis-Associated Ovarian Carcinoma (EAOC) Carcinogenesis Model with Endometrial Autoimplantation and DMBA Induction	2021	Asian Pacific Journal of Cancer Prevention	22	2	553	558	3	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102225233&doi=10.31557%2fAPJCP.2021.22.2.553&partnerID=40&md5=0851ed3cc33bf297db42accf77d7988a	Department of Anatomical Pathology, Medicine Universitas Indonesia; Animal Research Facilities, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia; Specialty Programme in Anatomical Pathology, Department of Anatomical Pathology, Medicine Universitas Indonesia; Department of Obstetrics and Gynecology, Medicine Universitas Indonesia; Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia	Wuyung, P.E., Department of Anatomical Pathology, Medicine Universitas Indonesia, Animal Research Facilities, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia; Rahadiati, F.B., Specialty Programme in Anatomical Pathology, Department of Anatomical Pathology, Medicine Universitas Indonesia; Tjahjadi, H., Department of Anatomical Pathology, Medicine Universitas Indonesia; Salinah, S., Department of Anatomical Pathology, Medicine Universitas Indonesia; Kusmardi, K., Department of Anatomical Pathology, Medicine Universitas Indonesia; Kodariah, R., Department of Anatomical Pathology, Medicine Universitas Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Medicine Universitas Indonesia, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia	Background: Ovarian carcinoma is one of the most deadly malignancies in the gynecologic field. The cause is not yet known, and the clinical symptoms are not specific. Endometrioid carcinoma and ovarian clear cell carcinoma can originate from endometriosis and are known as endometriosis-related ovarian carcinoma (EAOC). Development of EAOC experimental animal models is needed for basic research and clinical preparation of human tissue tests. This study aimed to determine the role of the Arid1a gene mutation in the carcinogenetic process of EAOC in experimental animal models induced with DMBA. Methods: In this study, the EAOC experimental model was developed using the autoimplantation technique and DMBA induction. This study involved placebo surgery mice (sham), endometrial autoimplantation, and a combination of endometrial autoimplantation and DMBA induction, which were sacrificed at weeks 5, 10, and 20, respectively. Histopathological assessment and immunohistochemical Arid1a staining with an assessment of positive percentages were carried out on 200 cells. Results: This study produced 1 (20%) atypical endometriosis and 1 (20%) clear cell carcinoma at implantation and after 10 weeks of DMBA induction, and 100% endometrioid carcinoma in the DMBA-induced group. Arid1a staining did not show any significant difference (p = 0.313) in all groups. Conclusion: The combination of endometrial autoimplantation techniques and DMBA induction in the ovary produced atypical endometriosis, clear cell carcinoma, and endometrioid carcinoma, where time is an important factor. There was no significant difference in Arid1a expression between the treatment and control groups. © 2021. All Rights Reserved.	Arid1a; DMBA; EAOC; Endometriosis; experimental animal model	ARID1A protein, human; DNA binding protein; transcription factor; animal; autotransplantation; carcinoma; complication; disease model; endometriosis; endometrium; female; metabolism; ovary tumor; pathology; rat; transplantation; Animals; Carcinoma; Disease Models, Animal; DNA-Binding Proteins; Endometriosis; Endometrium; Female; Ovarian Neoplasms; Rats; Transcription Factors; Transplantation, Autologous	Asian Pacific Organization for Cancer Prevention	15137368	33639673	Article	Q2	512	9866	View
862	Putri M.I.A., Panigoro S.S., Harahap A.S., Pakasi T.A., Brahma B.	57222261965;56790104300;57218511857;23980778600;55675752700;	Acetic Acid and Iodine Staining for Determining Malignancy in Solid Tumors	2021	Asian Pacific Journal of Cancer Prevention	22	2	463	469		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102041256&doi=10.31557%2fAPJCP.2021.22.2.463&partnerID=40&md5=a2eb3a6ba0cc657be963217a4e5d6cce	Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais Cancer Hospital, National Cancer Center, Jakarta, Indonesia	Putri, M.I.A., Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Panigoro, S.S., Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.S., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pakasi, T.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Brahma, B., Department of Surgical Oncology, Dharmais Cancer Hospital, National Cancer Center, Jakarta, Indonesia	Objective: Surgical margin is an important prognostic factor in solid cancer surgery. Frozen section (FS), the gold standard for intraoperative surgical margin evaluation, requires extensive waiting time and expensive FS devices. The purpose of this diagnostic study was to verify whether multi-staining (MS) method with acetic acid and iodine could be used to differentiate malignant and non-malignant lesions of solid tumor. Methods: The study was conducted on patients with solid tumor who underwent surgery in the Surgical Oncology Division of Dr. Cipto Mangunkusumo General Hospital from December 2017 to April 2018. Samples measuring less than 5 mm, necrotic tissue sample, and patients who did not agree to participate in the study were excluded. Every specimen was divided into two, one side as unstained control and the other side as MS samples. MS samples were sprayed with 10% acetic acid combined with iodine. MS samples and unstained controls were sent for histopathologic results and the pathologist was blinded to group assignment. Acetowhitening reaction in the sample was an indication of a positive MS result, and the presence of malignant foci in the histopathology examination was classified as positive pathological results. Results: Five-hundredand-twenty samples were obtained from 150 patients. MS method was found to have sensitivity and specificity of 82%, and 63.5%, respectively. In subgroup analysis, we found that MS method has a sensitivity and specificity of 100% and 79.3%, respectively for epithelial breast tumor; 65.7% and 83.3%, respectively for thyroid nodules; and 94.1% and 33.3%, respectively for oral cavity tumors. MS method reacts positively to solid malignant tumor and negatively to benign tumor and normal tissue (from margin samples). Highest sensitivity was found for breast and oral cavity malignancy, and high specificity was found for thyroid cancers. Conclusion: This study provided an alternative staining method for intraoperative macroscopic surgical margin evaluation, especially for rural areas without frozen section facilities. © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.	Acetic acid; breast cancer; frozen section; iodine; oral cancer; solid tumor; thyroid cancer; vital staining	acetic acid; coloring agent; dyes, reagents, indicators, markers and buffers; iodide; Lugol's solution; adolescent; adult; aged; child; cross-sectional study; female; frozen section; human; male; middle aged; neoplasm; pathology; sensitivity and specificity; staining; surgical margin; young adult; Acetic Acid; Adolescent; Adult; Aged; Child; Coloring Agents; Cross-Sectional Studies; Female; Frozen Sections; Humans; Indicators and Reagents; Iodides; Male; Margins of Excision; Middle Aged; Neoplasms; Sensitivity and Specificity; Staining and Labeling; Young Adult	Asian Pacific Organization for Cancer Prevention	15137368	33639661	Article	Q2	512	9866	View
Associacao Arquivos de Neuro-Psiquiatria(1)
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772	Maryam R.S., Sahar J., Hastono S.P., Harimurti K.	57209730009;6508226729;57211434645;23473513200;	Common symptoms of alzheimer’s dementia that are easily recognizable by families [Sintomas comuns da demência de alzheimer facilmente reconhecíveis pelas famílias]	2021	Dementia e Neuropsychologia	15	2	186	191		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109080999&doi=10.1590%2f1980-57642021dn15-020005&partnerID=40&md5=7d8636011b9ebdb60c6dd608e999cc16	Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Faculty of Medicine, Universitas Indonesia, Jawa Barat, Indonesia; Faculty of Public Health, Universitas Indonesia, Jawa Barat, Indonesia	Maryam, R.S., Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Sahar, J., Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Hastono, S.P., Faculty of Medicine, Universitas Indonesia, Jawa Barat, Indonesia; Harimurti, K., Faculty of Public Health, Universitas Indonesia, Jawa Barat, Indonesia	The increase in dementia incidence among the elderly is directly related to aging, which is associated with changes in bodily functions and other health-related risk factors. Alzheimer’s dementia is the most prevalent form of dementia, and individuals in the late stages are predominantly dependent on other family members. Therefore, it is important for families, as the closest support group, to recognize common symptoms early. Objective: To provide a family-friendly guide to the ten common symptoms of Alzheimer’s dementia. Methods: This is a descriptive survey-based research that included 354 families comprising elderly people (≥60 years) residing in Jakarta. The instrument aimed at identifying ten common Alzheimer’s dementia symptoms in Indonesia. Descriptive statistical analysis based on frequency tables was used. Results: The participant’s major characteristics were age ≥66 years (52.3%), female sex (70.3%) and primary school education (87.3%). The predominant symptoms experienced by 42.4% of the elderly included forgetting recent events and asking questions and narrating a particular detail repeatedly. The remaining 35.6% demonstrated signs of forgetting where an item was placed and frequently suspecting others of theft and concealment of personal items. Conclusion: The symptoms of frequently forgetting new events and the location of personal belongings are of particular concern for families, as they have a propensity to progress and interfere with daily activities. Therefore, the families of affected individuals are expected to identify this symptom early on and present the affected individual for screening or examination at a health care facility. © 2021, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.	Alzheimer disease; Dementia; Family; Memory disorders		Associacao Arquivos de Neuro-Psiquiatria	19805764		Article	Q3	540	9365	View
Atlantis Press(1)
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657	Irawan C., Benbella L.G., Rachman A., Mansjoer A.	28767651600;57357413600;15056701600;24335647800;	Factors that Influence 2-Year Progression-Free Survival Among Head and Neck Cancer Patients	2021	Journal of Epidemiology and Global Health						https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120335157&doi=10.1007%2fs44197-021-00016-2&partnerID=40&md5=eae0237d32c525daedf560529a50ad64	Hematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jl. Diponegoro no. 71, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jakarta, Indonesia; Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jakarta, Indonesia	Irawan, C., Hematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jl. Diponegoro no. 71, Jakarta, 10430, Indonesia; Benbella, L.G., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jakarta, Indonesia; Rachman, A., Hematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jl. Diponegoro no. 71, Jakarta, 10430, Indonesia; Mansjoer, A., Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jakarta, Indonesia	Objectives: The majority of patients with head and neck cancer (HNC) come to the hospital at advanced stages. This research was conducted to determine the mortality, 2-year progression-free survival (PFS) and factors that influenced PFS of HNC patients. Methods: A retrospective cohort study was conducted among locally advanced HNC patients who underwent chemoradiation for the first time at RSCM from January 2015 to December 2017. Data were retrieved through medical records. Laboratory data were taken 2–4 weeks prior and 2–4 weeks after chemoradiation. PFS observation started from the first day of chemoradiation until disease progression or death. PFS data were recorded in two groups: ≤ 2 years and > 2 years. The Chi-square test was used for bivariate analysis with the Fischer-exact test as an alternative. Variables will be further tested using multivariate logistic regression tests. Results: Among 216 subjects, there were 103 (47.69%) patients who did not reach overall survival (OS) > 2 years. There were 108 (50%) patients who had PFS > 2 years. Based on the results of multivariate analysis, it was found that smoking, hemoglobin level ≤ 12 g/dl, ECOG (Eastern Cooperative Oncology Group) 1–2, and negative therapeutic response were associated with poor PFS. Hazard ratio (HR) for 2-year PFS for Brinkman index > 250 was 1.36 (95% CI 0.93–2.00; p = 0.02); HR for Hb ≤ 12 g/dl was 1.65 (95% CI 1.13–2.42; p = 0.01); HR for ECOG 1–2 was 4.05 (95% CI 1.49–11.00; p < 0.01); and HR for negative therapeutic response was 2.37 (95% CI 1.43–3.94; p < 0.01). Conclusion: Mortality of HNC patients within 2 years is 47.69%, with a 2-year PFS reaching 50%. Cigarette smoking, low hemoglobin levels, poor performance status, and negative therapeutic response (non-responders) negatively affect the 2-year PFS. © 2021, The Author(s).	Factor; Head and neck cancer; Mortality; Progression-free survival		Atlantis Press	22106006		Article	Q3	665	7531	View
AVES(1)
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12	Ramlan A.A.W., Mahri I., Firdaus R., Sugiarto A.	57195941841;57459772200;57188923555;57189612291;	Comparison of Efficacy of Premedication between Dexmedetomidine and Midazolam Intranasal for the Prevention of Emergence Delirium in Children Undergoing Ophthalmic Surgery	2021	Turkish Journal of Anaesthesiology and Reanimation	49	6	439	444		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124935387&doi=10.5152%2fTJAR.2021.1305&partnerID=40&md5=bd1c40a8ff29473a6db3aa32aacb92ad	Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mahri, I., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Firdaus, R., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Objective: Emergence delirium (ED) is a condition that can occur when a child recovers from anaesthesia uncomfortably. ED can potentially injure children and indirectly discomforts parents. Various interventions were carried out to reduce ED, but there is no specific standard that has been established to prevent ED. Dexmedetomidine and midazolam are said to be effective in reducing ED. This study aims to determine the effectiveness of intranasal dexmedetomidine premedication compared to intranasal midazolam to prevent ED in children undergoing eye surgery. Methods: This study was a double-blinded randomised clinical trial. Paediatric patients aged 1-12 years with physical status ASA 1 and 2 who underwent eye surgery under general anaesthesia using sevoflurane inhalation were included in the study. There were 64 children obtained by consecutive sampling who underwent eye surgery in our institution between February and May 2019. The subjects were then randomised into the dexmedetomidine group and the midazolam group. Effectiveness was assessed from ED events, recovery time and post-premedication desaturation events. Data analysis was performed using Chi-square test and Mann–Whitney test. Results: ED incidence in the dexmedetomidine group was 11.18% compared to 28.12% in the midazolam group (P = .109). The recovery time was found to be at a median of 6 minutes for both groups, and no desaturation was found in either group. Conclusion: There is statistically no significant difference between the effectiveness of intranasal dexmedetomidine and midazolam premedication 30 minutes before induction to prevent ED occurrence in children undergoing eye surgery. © 2021 by Turkish Society of Anaesthesiology and Reanimation.	Delirium; Dexmedetomidine; Emergence; Eye surgery; Midazolam		AVES	2667677X		Article	Q3	322	14155	View
Avicena Publishing(1)
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743	Soeroso N.N., Ananda F.R., Pradana A., Tarigan S.P., Syahruddin E., Noor D.R.	57201670271;57201666959;57202578193;6602815057;6507688750;57214096801;	The absence of mutations in the exon 2 kras gene in several ethnic groups in north sumatra may not the main factor for lung cancer	2021	Acta Informatica Medica	29	2	108	112		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111477707&doi=10.5455%2fAIM.2021.29.108-112&partnerID=40&md5=4854ca99a072394cbd039b5f66172820	Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia	Soeroso, N.N., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Ananda, F.R., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Pradana, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Tarigan, S.P., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Syahruddin, E., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia; Noor, D.R., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia	Background: Rat Sarcoma (RAS) protein encoded Guanosine Triphosphate (GTP-ase) activity, known as a switch of cell proliferation. The mutation of this protein alters the early stage of carcinogenesis and along with the interaction with other oncogene drivers and environmental factors affect the clinical characteristics and prognosis in cancer patients, particularly lung cancer. Objective: This study aims to determine the Kristen Rat Sarcoma (KRAS) mutation in lung cancer patients in North Sumatera and evaluate factors that might contribute in the development of lung cancer in the absence of KRAS mutation. Methods: This was a retrospective cohort study enrolled 44 subjects age > 18 year with the diagnosis of lung cancer. Histopathology preparation was obtained from surgery, bronchoscopy, and percutaneus needle biopsy then formed as paraffin-block. KRAS mutation was analyzed using Polymerase Chain Reaction (PCR) method with specific primer of exon 2 for evaluating the expression of RAS protein then continued with Sanger Sequencing Method at 12th and 13th codon. Results: The majority of subjects were male, age > 40 years old, bataknese, heavy smoker, with Adenocarcinoma. Almost all the subjects showed the expression of exon 2 of RAS protein in PCR examinations. However, Sequencing analysis using Bioedit Software, BLASTs and Finch T showed GGT GGC as protein base 219-224 which represented 12th and 13th Codon 12 and 13. The results interpreted there was no mutations of exon 2 of KRAS in North Sumatera Population. Conclusion: The absence of KRAS mutation in exon 2 in several ethnics in North Sumatera populations was not the main factors of lung cancer. © 2021 Noni Novisari Soeroso, Fannie Rizki Ananda, Andika Pradana, Setia Putra Tarigan, Elisna Syahruddin, Dimas Ramadhian Noor	Ethnic variation; Exon 2; Indonesian; KRAS mutation; Lung cancer	K ras protein; adult; age; Article; bronchoscopy; cancer diagnosis; cancer patient; cancer surgery; clinical article; cohort analysis; controlled study; ethnic difference; female; gender; gene expression; gene mutation; histopathology; human; lung adenocarcinoma; lung cancer; male; needle biopsy; polymerase chain reaction; retrospective study; Sanger sequencing; smoking	Avicena Publishing	03538109		Article	Q3	267	15980	View
Avicenna Research Institute(1)
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769	Birowo P., Tendi W., Rasyid N., Turek P.J., Sini I.R., Rizal M.	6504153311;57208641745;56245069300;7006101528;56013404300;57225198196;	Successful targeted testicular sperm extraction using microsurgical technique (microtese) following fine needle aspiration (FNA) mapping in a non-obstructive azoospermia (NOA) patient: A case report	2021	Journal of Reproduction and Infertility	22	1	65	69	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109425367&doi=10.18502%2fjri.v22i1.4997&partnerID=40&md5=fa081e0db7b5deb36d248beb2dcda6dd	Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia; Turek Clinic, San Francisco, United States	Birowo, P., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia; Tendi, W., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Turek, P.J., Turek Clinic, San Francisco, United States; Sini, I.R., Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia; Rizal, M., Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia	Background: Management for male infertility can be difficult for some cases. Surgical intervention has long been thought as the last resort to help married couples to conceive. The current guideline recommends testicular sperm extraction with microsurgery technique (microTESE) in severe cases of male infertility. However, the success rate still varies. Thus, a new strategy was needed to further increase the sperm retrieval success rate. Case Presentation: A 39-year-old male with a history of failed sperm extraction, non-obstructive azoospermia (NOA) and Y-chromosomal microdeletion came to the fertility center to undergo sperm retrieval. Fine needle aspiration (FNA) Mapping was performed prior to microTESE to increase the accuracy of sperm retrieval. After further examination with laser assisted immotile sperm selection (LAISS), five spermatozoa were found. Conclusion: The combination of FNA Mapping and microTESE increases the chance of a successful sperm extraction. © 2021 Avicenna Research Institute. All rights reserved.	Fna mapping; Laiss; Microtese; Noa; Y-chromosomal microdeletion	chorionic gonadotropin; clomifene citrate; follitropin; ovutrig; testosterone; adult; Article; azoospermia; case report; chromosome deletion; clinical article; clinical effectiveness; echography; fine needle aspiration biopsy; fine needle aspiration mapping; human; human tissue; intracytoplasmic sperm injection; laser assisted immotile sperm selection; male; male infertility; microsurgical epididymal sperm aspiration; microsurgical testicular sperm extraction; percutaneous epididymal sperm aspiration; physical examination; pronucleus; sperm retrieval; spermatid; spermatocyte; spermatozoon; testicular sperm extraction; testis biopsy; testis size; varicocele; Y chromosome	Avicenna Research Institute	22285482		Article	Q3	495	10168	View

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