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222 |
Sirait B., Wiweko B., Jusuf A.A., Iftitah D., Muharam R. |
57222720264;43061741400;57192275719;57195199068;57191492732; |
Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review |
2021 |
Frontiers in Cell and Developmental Biology |
9 |
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710292 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114781833&doi=10.3389%2ffcell.2021.710292&partnerID=40&md5=0430c11851bd72e4085a2092ee2bfda4 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia; Morula IVF Jakarta Clinic, Jakarta, Indonesia; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sirait, B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia, Morula IVF Jakarta Clinic, Jakarta, Indonesia; Wiweko, B., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iftitah, D., Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Oocyte developmental competence is one of the determining factors that influence the outcomes of an IVF cycle regarding the ability of a female gamete to reach maturation, be fertilized, and uphold an embryonic development up until the blastocyst stage. The current approach of assessing the competency of an oocyte is confined to an ambiguous and subjective oocyte morphological evaluation. Over the years, a myriad of biomarkers in the cumulus-oocyte-complex has been identified that could potentially function as molecular predictors for IVF program prognosis. This review aims to describe the predictive significance of several cumulus-oocyte complex (COC) biomarkers in evaluating oocyte developmental competence. A total of eight acclaimed cumulus biomarkers are examined in the study. RT-PCR and microarray analysis were extensively used to assess the significance of these biomarkers in foreseeing oocyte developmental competence. Notably, these biomarkers regulate vital processes associated with oocyte maturation and were found to be differentially expressed in COC encapsulating oocytes of different maturity. The biomarkers were reviewed according to the respective oocyte maturation events namely: nuclear maturation, apoptosis, and extracellular matrix remodeling, and steroid metabolism. Although substantial in vitro evidence was presented to justify the potential use of cumulus biomarkers in predicting oocyte competency and IVF outcomes, the feasibility of assessing these biomarkers as an add-on prognostic procedure in IVF is still restricted due to study challenges. © Copyright © 2021 Sirait, Wiweko, Jusuf, Iftitah and Muharam. |
biomarker; cumulus-oocyte complex (COC); in-vitro fertilization; oocyte competence; oocyte maturation |
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Frontiers Media S.A. |
2296634X |
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Review |
Q1 |
2452 |
946 |
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223 |
Razeghian E., Margiana R., Chupradit S., Bokov D.O., Abdelbasset W.K., Marofi F., Shariatzadeh S., Tosan F., Jarahian M. |
57223052224;56685900600;57211329338;56845561300;57208873763;57199650994;57225946579;57216155951;16241593900; |
Mesenchymal Stem/Stromal Cells as a Vehicle for Cytokine Delivery: An Emerging Approach for Tumor Immunotherapy |
2021 |
Frontiers in Medicine |
8 |
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721174 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114747651&doi=10.3389%2ffmed.2021.721174&partnerID=40&md5=eb488365f37edbafb0ec0a51d29dbfc9 |
Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Razeghian, E., Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Shariatzadeh, S., Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Tosan, F., Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Pro-inflammatory cytokines can effectively be used for tumor immunotherapy, affecting every step of the tumor immunity cycle. Thereby, they can restore antigen priming, improve the effector immune cell frequencies in the tumor microenvironment (TME), and eventually strengthen their cytolytic function. A renewed interest in the anticancer competencies of cytokines has resulted in a substantial promotion in the number of trials to address the safety and efficacy of cytokine-based therapeutic options. However, low response rate along with the high toxicity associated with high-dose cytokine for reaching desired therapeutic outcomes negatively affect their clinical utility. Recently, mesenchymal stem/stromal cells (MSCs) due to their pronounced tropism to tumors and also lower immunogenicity have become a promising vehicle for cytokine delivery for human malignancies. MSC-based delivery of the cytokine can lead to the more effective immune cell-induced antitumor response and provide sustained release of target cytokines, as widely evidenced in a myriad of xenograft models. In the current review, we offer a summary of the novel trends in cytokine immunotherapy using MSCs as a potent and encouraging carrier for antitumor cytokines, focusing on the last two decades' animal reports. © Copyright © 2021 Razeghian, Margiana, Chupradit, Bokov, Abdelbasset, Marofi, Shariatzadeh, Tosan and Jarahian. |
cytokine; cytokine delivery; gene therapy; mesenchymal stem/stromal cells; tumor-immunotherapy |
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Frontiers Media S.A. |
2296858X |
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Review |
Q1 |
1388 |
2608 |
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228 |
Reksodiputro M.H., Harahap A.R., Setiawan L., Yosia M. |
35090488800;6507325543;57053036100;57204933098; |
A Modified Preparation Method of Ideal Platelet-Rich Fibrin Matrix From Whole Blood |
2021 |
Frontiers in Medicine |
8 |
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724488 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114628863&doi=10.3389%2ffmed.2021.724488&partnerID=40&md5=2a784dc8d442d97efac9d34d1c6769cc |
Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Reksodiputro, M.H., Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.R., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Setiawan, L., Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
One bioproduct that is widely used in the wound healing process is platelet-rich plasma (PRP). PRP is a liquid solution with high autologous platelet concentration, making it a good source of growth factors to accelerate wound healing. Recent development in PRP had created a new product called platelet-rich fibrin matrix (PRFM), which has a denser and more flexible structure. PRFM is the newest generation of platelet concentrate with a fibrin matrix that holds platelet in it. The key concept in creating PRFM from PRP is the addition of CaCl2 followed by centrifugation, which converts fibrinogen to fibrin, and the fibrin cross-links to form a matrix that contains viable platelets. There are many commercially available kits to create PRFM, but they are often expensive and uneconomical. This research will test a modified method of making ideal PRFM from PRP without any commercial kits. The modified method will include determining the minimum level of CaCl2 used, the type of centrifuge, and the speed and duration of centrifugation. By performing a modified preparation method on five samples of whole blood, it was found that the ideal PRFM could be made by mixing PRP with 25 mM CaCl2 and centrifuging it at a speed of 2,264 × g for 25 min at room temperature. The PRP and PRFM platelet counts of this method tend to be lower than the platelet counts found in other studies. Although visually comparable, further study is needed to compare the performance of PRFMs made with this method and PRFMs made with commercial kits. © Copyright © 2021 Reksodiputro, Harahap, Setiawan and Yosia. |
CaCl2; centrifugation; fibrin matrix; platelet concentrate; platelet rich fibrin matrix; platelet rich plasma |
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Frontiers Media S.A. |
2296858X |
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Article |
Q1 |
1388 |
2608 |
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229 |
Nadhif M.H., Irsyad M., Rahyussalim A.J., Utomo M.S. |
57189057498;57220935587;55212166100;56180933900; |
Geometrical evaluation of CAM-configured thermoplastic polyurethane lattices for intervertebral disc replacements |
2021 |
AIP Conference Proceedings |
2382 |
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030006 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114011637&doi=10.1063%2f5.0060049&partnerID=40&md5=894c1cbce6bdc985a2b86b40dcf80e06 |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Central Hospital, Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Banten, 15310, Indonesia |
Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Rahyussalim, A.J., Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Central Hospital, Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Banten, 15310, Indonesia |
Intervertebral discs (IVD) are prone to deformation due to higher stress that the discs can endure. Treatments for deformed IVDs include total disc replacements. Some studies concluded the superiority of spinal fusion compared to total disc replacement devices, either in the lumbar or cervical region. In current study, cuboid scaffolds made of thermoplastic polyurethane with lattice architecture were designed and configured using computer-aided manufacturing (CAM). The scaffolds were fabricated using fused filament fabrication. Process parameters were characterized and optimized to obtain scaffolds with uniform cells distribution. The struts at the top surface had average width values closer to the setpoints than the struts at the bottom surface, indicated by lower RMSE values for the struts at the top surface. However, the printing consistency in the same extrusion ratio at the bottom surface was higher than at the top surface, indicated by lower standard deviation values. Statistical analysis using standard deviation, RMSE, and Tukey's test showed that current scaffolds had non-uniform distribution between layers, which required further improvement. © 2021 Author(s). |
Computer-aided manufacturing; intervertebral disc; lattice structure; polyurethane |
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American Institute of Physics Inc. |
0094243X |
9780735441156 |
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Conference Paper |
- |
177 |
20880 |
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234 |
Nugroho S.W., Pradhana I., Gunawan K. |
57460519700;57373805000;57195935319; |
New adaptation of neurosurgical practice and residency programs during the Covid-19 pandemic and their effects on neurosurgery resident satisfaction and welfare at the National General Hospital, Jakarta, Indonesia |
2021 |
Heliyon |
7 |
8 |
e07757 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121271314&doi=10.1016%2fj.heliyon.2021.e07757&partnerID=40&md5=09cbd414f0eefb36b6d98b642efa84cf |
Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Nugroho, S.W., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pradhana, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gunawan, K., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Many institutions in numerous countries have made changes in their health care services during the COVID-19 pandemic. One change has been to reduce elective neurosurgery cases, which has impacted neurosurgery education. Published literature is lacking about the healthcare services, education, and residents’ well-being during adaptation to the pandemic, especially in national referral hospitals in developing countries. Methods: We conducted a cross-sectional study on current neurosurgical services during 2020. We evaluated 34 neurosurgery residents in Cipto Mangunkusumo National General Hospital using a self-made questionnaire to determine the effects of the COVID-19 pandemic on their surroundings, education process, and satisfaction with the currently adapted education program. We used the modified Maslach Burnout Inventory to assess burnout in the residents before and during the pandemic. Results: Neurosurgical residents spent more time studying neurosurgical theory (Mode 1–1.5h/day, p < 0.05) but spent less time learning neurosurgical skills (Mode 30 min–1 h/day, p < 0.05) compared to before the pandemic. The resident satisfaction mean score (scale 0–10) was 7.58 for live surgery and 8.53 for the microsurgical skills lab training program. On a scale of 1–10, the residents’ stress level increased after the pandemic but the change was not statistically significant (6.61 ± 1.87, p > 0.05). The Modified Maslach Burnout inventory score was 3.02 ± 3.74 during the pandemic, and increased from before the pandemic (2.41 ± 3.18), but the difference was not statistically significant. Conclusion: The COVID-19 pandemics have reduced the working hours and the clinical exposure of neurosurgical residents. Fortunately, this pandemic has led to a new opportunity to find many suitable learning methods which may decrease the risk of burnout. The psychological burden of residents is still worrisome, and planned management is necessary to sustain resident performance. © 2021 |
COVID-19; Education; Neurosurgery; Neurosurgical residency; Pandemic; Residency |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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235 |
Widaty S., Menaldi S.L., Rihatmadja R., Miranda E., Marissa M., Kekalih A., Friska D., Oktarina C., Surya D. |
57208261546;57192918198;56427016700;57208259598;57210795916;55633562200;57202805330;57208263598;57210797458; |
Involvement of non-medical personnel in management of scabies at a boarding school in Indonesia |
2021 |
Southeast Asian Journal of Tropical Medicine and Public Health |
52 |
4 |
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527 |
537 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119906461&partnerID=40&md5=3b9a6a331f595bc79905a0e28fbc7d70 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Menaldi, S.L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Rihatmadja, R., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Kekalih, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktarina, C., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Surya, D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
One of the most common neglected tropical skin diseases in Indonesia is scabies, commonly associated with overcrowding, poor hygiene and poor nutritional status. Boarding schools are at risk of harboring infected populations. As recurrence is common, non-medical personnel need to be involved in management of scabies. This study aimed to investigate how non-medical personnel, in this case, the boarding school teachers, could manage scabies in a boarding school in Indonesia. We trained the teachers using the education module for early scabies detection approach, namely DeSkab program, to be able to identify three major signs of scabies in the students. Impact of this approach was evaluated in 2017 and 2018 at a religious boarding school in Bogor, Indonesia involving 127 and 202 students, consecutively. An education module was given to 16 boarding school teachers expecting them to be able to examine students prior to school admission and before and after mid-semester break. Teachers’ knowledge increased significantly after the training (p <0.001). This knowledge improvement is an important basis for teachers as non-medical personnel to implement independent scabies monitoring process during the educational year to find students with suspected scabies. Those suspected scabies students were directly referred to nearby public health clinic and treated with 5% permethrin and re-treated one week later. Prevalence of scabies decreased from 76% in 2017 to 49% in 2018 in 69 students who can be followed-up in two consecutive years (p-value = 0.014). In conclusion, involvement of non-medical personnel is an essential and effective strategy to improve management of scabies. © 2021, SEAMEO TROPMED Network. All rights reserved. |
Boarding school; DeSkab; Non-medical personnel; Prevention; Scabies |
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SEAMEO TROPMED Network |
01251562 |
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Article |
Q4 |
214 |
18533 |
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238 |
Heltty H., Sitorus R., Nusdwinuringtyas N., Martha E. |
57262112500;57194329674;56608215500;55841280100; |
Effect of Self-Regulation and Social Support Intervention on the Life Quality in Patients with Post-Stroke Urinary Incontinence |
2021 |
Korean Journal of Adult Nursing |
33 |
4 |
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399 |
405 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115059615&doi=10.7475%2fkjan.2021.33.4.399&partnerID=40&md5=167ab64de29a0974bb46e8b9444819a3 |
Doctoral Student of Nursing Faculty, Universitas Indonesia, Depok Indonesia, Jl. Prof. Dr. Bahder Djohan, Kampus UI Depok Jawa Barat, Indonesia; Professor of Nursing, Faculty of Nursing, Universitas Indonesia, Jl. Prof. Dr. Bahder Djohan, Kampus UI Depok Jawa Barat, Indonesia; Associate Professor Ph.D, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Associate Professor Ph.D M.Kes (health), Faculty of Public Health, Universitas Indonesia, Depok, Indonesia |
Heltty, H., Doctoral Student of Nursing Faculty, Universitas Indonesia, Depok Indonesia, Jl. Prof. Dr. Bahder Djohan, Kampus UI Depok Jawa Barat, Indonesia; Sitorus, R., Professor of Nursing, Faculty of Nursing, Universitas Indonesia, Jl. Prof. Dr. Bahder Djohan, Kampus UI Depok Jawa Barat, Indonesia; Nusdwinuringtyas, N., Associate Professor Ph.D, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Martha, E., Associate Professor Ph.D M.Kes (health), Faculty of Public Health, Universitas Indonesia, Depok, Indonesia |
Purpose: This study aimed to determine the effect of self-regulation and social support on post-stroke patients experiencing urinary incontinence. Methods: This quasi-experimental study was conducted in Kota Kendari, Indonesia. Through consecutive sampling, 53 participants were selected: 26 in the experimental groups and 27 in the control group, studied over a period of four weeks. The self-regulation intervention included education about properly following recommended exercises to overcome urinary incontinence, focusing on goals, being optimistic, and having emotional control. The social support intervention included the provision of family and peer support during patient care. Differences in participants' quality of life was measured at three different stages during the study, using the Incontinence Quality of Life instrument. Data were analyzed using descriptive statistics, independent t-tests, and repeated measures ANOVA. Results: There was homogeneity of variance in both groups. Significant differences in quality of life were seen in the second and third measurements (p<.001). The interventions improved patients' quality of life by 6.43 times at 4 weeks, and 13 times at 8 weeks. Conclusion: Self-regulation and social support played an important role in improving the quality of life of post-stroke urinary incontinence patients. Further studies with longer intervention periods are required to validate our results and contribute to better patient experiences. © 2021. All Rights Reserved. |
Emotional regulation; Quality of life; Social support; Stroke; Urinary incontinence |
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Korean Society of Adult Nursing |
12254886 |
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Article |
Q3 |
253 |
16577 |
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239 |
Sobri F.B., Bachtiar A., Panigoro S.S., Rahmaania J.C., Yuswar P.W., Krisnuhoni E., Tandiari N. |
57217500979;56683183900;56790104300;57252632900;57253490900;35310982200;57252633000; |
Strategy for diagnosing breast cancer in Indonesia during the COVID-19 pandemic: Switching to ultrasound-guided percutaneous core needle biopsy |
2021 |
Kesmas |
16 |
3 |
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151 |
157 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114650507&doi=10.21109%2fkesmas.v16i3.4359&partnerID=40&md5=dbf4756507a59d7c2f87cc7eb69f6787 |
Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgical Oncology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pathology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Department of Radiology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia |
Sobri, F.B., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia, Department of Surgical Oncology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Bachtiar, A., Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Panigoro, S.S., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmaania, J.C., Department of Surgery, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Yuswar, P.W., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Pathology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia; Tandiari, N., Department of Radiology, Metropolitan Medical Centre Hospital, Jakarta, Indonesia |
In this era of COVID-19, suspected breast cancer patients experience delay in diagnosis due to the fear of contracting the virus and reduction of non-COVID-19 health services. Furthermore, it may lead to potential increase in the incidence of advanced cancers in the future. Ultrasound-guided (US-guided) percutaneous core needle biopsy (CNB) is a great option for the diagnosis of cancer but it is poorly utilized. This study aimed to prove that the US-guided CNB is accurate when performed in a local setting and a potential solution for diagnosing breast cancer patients in this pandemic. In addition, it was a single health center cross-sectional study, and the participants were all breast cancer patients that had US-guided CNB from 2013-2019. The pathology results from US-guided CNB were compared to specimens from post-CNB surgeries. The data were collected from medical records and the immunohistochemistry (IHC) examinations were carried out for malignancy. There were 163 patients who were included in this study, 86 had malignancies and 77 had benign tumor reported in their CNB results. The US-guided CNB had 100% sensitivity and specificity compared to surgery. With its lower cost, time usage, and patient exposure to the hospital environment, US-guided CNB should replace open surgery biopsy for diagnosing suspicious breast cancers during the pandemic in Indonesia. Copyright © 2021, Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal). |
Breast cancer; Core needle biopsy; COVID-19; Health cost; Resources |
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Universitas Indonesia, Faculty of public health |
19077505 |
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Article |
Q4 |
146 |
23606 |
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240 |
Nathania M., Sunardi D. |
57245860300;57192075078; |
The importance of balanced nutrition to fortify the immune system during the covid-19 outbreak [La importancia de una nutrición equilibrada para aumentar el sistema inmunológico durante el brote de covid-19] |
2021 |
Revista Chilena de Nutricion |
48 |
4 |
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620 |
629 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114246311&doi=10.4067%2fS0717-75182021000400620&partnerID=40&md5=c999acae5c75b659b516d0fbb8b1815b |
Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia |
Nathania, M., Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia; Sunardi, D., Department of Nutrition, Faculty of Medicine, University of Indonesia-Ciptomangunkusumo National Hospital, Jakarta Pusat, 10430, Indonesia |
COVID-19, first reported in December 2019 in Wuhan, China, quickly spread worldwide and was announced as a pandemic in March 2020. As symptoms and outcomes are varied, the elderly and those who have at least one comorbidity (diabetes, cardiovascular disorders or other chronic diseases) are considered to be at high risk and are generally have lower immunity. An optimal immune system is critical for survival, as it protects the body against infectious agents. Nutrition is an essential factor in the immune system, contributing to components in physical barriers, biochemical, innate and adaptive immunity. Research advances show that nutritional deficiencies, namely the inadequacy of energy, macronutrients and micronutrients, affect the immune system and increase infection risk. The following discussion explains the comprehensive role of nutrition in the immune system, nutrition recommendations that can be used as precautions and the need for supplementation during this outbreak. © 2021, Sociedad Chilena de Nutricion Bromatologia y Toxilogica. All rights reserved. |
COVID-19; Immune; Nutrition; Pandemic; Supplementation |
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Sociedad Chilena de Nutricion Bromatologia y Toxilogica |
07177518 |
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Review |
Q4 |
182 |
20570 |
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246 |
Ichwan S., Ningsih H.L., Aman R.A., Tandian D., Ashari S., Gunawan K., Nugroho S.W. |
57192906639;57226696258;36848942500;57192891173;57195942105;57195935319;57460519700; |
O6-methylguanine-dna methyltransferase (Mgmt) promoter methylation status of high-grade and low-grade gliomas |
2021 |
Bali Medical Journal |
10 |
2 |
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644 |
647 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112380308&doi=10.15562%2fbmj.v10i2.2316&partnerID=40&md5=c8e8a17690a11b9cc2f1729ff7a40de8 |
Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Ichwan, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ningsih, H.L., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aman, R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tandian, D., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ashari, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gunawan, K., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nugroho, S.W., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background: O6-methylguanine-DNA methyltransferase (MGMT) is a DNA-repair enzyme that correlates with tumor resistance mechanism to chemotherapy. Methylation of the MGMT promoter inhibits the cells from producing MGMT and is useful to predict chemotherapy’s effectiveness with alkylating agents. This study aims to evaluate the MGMT promoter methylation of low-grade and high-grade glioma in the Neurosurgery Department of Cipto Mangunkusumo National General Hospital. Methods: We evaluated MGMT promoter methylation status using methylation-specific polymerase chain reaction in low and high-grade glioma patients who underwent surgical resection in the Neurosurgery Department of Cipto Mangunkusomo Hospital Jakarta. The result then correlated with age, sex, Karnofsky Performance Scale (KPS), and glioma grading. Data were analyzed using SPSS version 20 for Windows. Results: MGMT promoter methylation was observed more often in patients diagnosed with age more than 40 years old than in patients less than 40 years old (85.7% vs. 50.0%), also more in men than women (77.7% vs. 50.0%). In patients with KPS more than 70 and KPS 70 or less, methylation of MGMT promoter was observed in 70.0% and 57.1%, respectively. Based on tumor grading, MGMT promoter methylation was observed more often in low-grade gliomas (WHO grade II) than high-grade gliomas (WHO grade II and IV) (85.7% vs. 50.0%). There was no significant relationship between gender, age, KPS, malignancy degree, and Overall Survival (OS) to the MGMT promoter methylation (p>0.05). Conclusion: MGMT promoter methylation was observed less in the higher grade of tumors (grade IV), lower KPS, younger age at the time of diagnosis, and female patients, although the differences were not statistically significant. MGMT promoter methylation was observed more often in gliomas with oligodendroglioma components. © 2021, Sanglah General Hospital. All rights reserved. |
High-grade glioma; Low-grade glioma; Methylation; MGMT; Promoter |
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Sanglah General Hospital |
20891180 |
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Article |
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