548 |
Pranata R., Henrina J., Lim M.A., Lawrensia S., Yonas E., Vania R., Huang I., Lukito A.A., Suastika K., Kuswardhani R.A.T., Setiati S. |
57201973901;57218482646;57216039756;57219781613;57201987097;57208328436;57208576645;57213835420;8736266500;36863900500;14325991900; |
Clinical frailty scale and mortality in COVID-19: A systematic review and dose-response meta-analysis: Clinical Frailty Scale in COVID-19 |
2021 |
Archives of Gerontology and Geriatrics |
93 |
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104324 |
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53 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098467342&doi=10.1016%2fj.archger.2020.104324&partnerID=40&md5=f9eef93f03ae5cb88ddf255820cbd190 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Siloam Heart Institute, Jakarta, Indonesia; Ken Saras General Hospital, Semarang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University Denpasar, Bali, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Denpasar - Bali, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Henrina, J., Siloam Heart Institute, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lawrensia, S., Ken Saras General Hospital, Semarang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Lukito, A.A., Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Suastika, K., Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University Denpasar, Bali, Indonesia; Kuswardhani, R.A.T., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Denpasar - Bali, Indonesia; Setiati, S., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: National Institute for Health and Care Excellence (NICE) endorsed clinical frailty scale (CFS) to help with decision-making. However, this recommendation lacks an evidence basis and is controversial. This meta-analysis aims to quantify the dose-response relationship between CFS and mortality in COVID-19 patients, with a goal of supplementing the evidence of its use. Methods: We performed a systematic literature search from several electronic databases up until 8 September 2020. We searched for studies investigating COVID-19 patients and reported both (1) CFS and its distribution (2) CFS and its association with mortality. The outcome of interest was mortality, defined as clinically validated death or non-survivor. The odds ratio (ORs) will be reported per 1% increase in CFS. The potential for a non-linear relationship based on ORs of each quantitative CFS was examined using restricted cubic splines with a three-knots model. Results: There were a total of 3817 patients from seven studies. Mean age was 80.3 (SD 8.2), and 53% (48–58%) were males. The pooled prevalence for CFS 1–3 was 34% (32–36%), CFS 4–6 was 42% (40–45%), and CFS 7–9 was 23% (21–25%). Each 1-point increase in CFS was associated with 12% increase in mortality (OR 1.12 (1.04, 1.20), p = 0.003; I2: 77.3%). The dose-response relationship was linear (Pnon-linearity=0.116). The funnel-plot analysis was asymmetrical; Trim-and-fill analysis by the imputation of two studies on the left side resulted in OR of 1.10 [1.03, 1.19]. Conclusion: This meta-analysis showed that increase in CFS was associated with increase in mortality in a linear fashion. © 2020 Elsevier B.V. |
Age; Coronavirus; COVID-19; Frailty; Prognosis; Risk stratification |
Article; Clinical Frailty Scale; coronavirus disease 2019; data analysis; functional status assessment; human; medical research; mortality; odds ratio; outcome assessment; prevalence; priority journal; quantitative analysis; systematic error; systematic review; frailty; male; meta analysis; very elderly; Aged, 80 and over; COVID-19; Frailty; Humans; Male; Prevalence; SARS-CoV-2 |
Elsevier Ireland Ltd |
01674943 |
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33352430 |
Article |
Q1 |
985 |
4466 |
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