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90 |
Lydia A., Yassir Y., Hidayat R., Suwarto S. |
8451287200;57463407000;37067327300;8443626100; |
The Association Between Uric Acid and Symmetric Dimethylarginine Levels in the Patients Undergoing Twice-weekly Hemodialysis |
2021 |
Nephro-Urology Monthly |
13 |
4 |
e117476 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125057044&doi=10.5812%2fNUMONTHLY.117476&partnerID=40&md5=8d20b0dc3cfeb796c8879fd9e2fd2a30 |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Lydia, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yassir, Y., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hidayat, R., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Suwarto, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Uric acid (UA) levels are associated with increased risk of cardiovascular events and mortality in hemodialysis pa-tients. However, there are still conflicting data on the mechanism of increased risks related to uric acid levels. Objectives: This study assessed the association between uric acid levels and symmetric dimethylarginine (SDMA), as a marker of cardiovascular disease, in the subjects undergoing hemodialysis twice weekly. Methods: This was a cross-sectional study conducted in a tertiary hospital in Jakarta, Indonesia. We included all the adults who underwent hemodialysis twice weekly for at least three months in our hospital. Subjects already on uric acid lowering therapy, pregnant or lactating women and those with a history of malignancy were excluded. Uric acid and SDMA levels were measured at the same time in pre-dialysis venous blood samples. Bivariate analysis was performed using the Mann-Whitney U test or one-way ANOVA. Results: A total of 126 subjects were included. The median level of UA was 8.4 mg/dL (IQR: 2.6, min: 4.1, max: 13.6), and 72 subjects (57.14%) had UA levels of 8 mg/dL or higher. The median SDMA level was 535.5 (312.7) mmol/dL (min: 119.7, max: 1895.5). Subjects with UA levels >8 mg/dL had significantly higher SDMA levels compared to subjects with UA levels < 8 mg/dL (550.1 (IQR: 357.25) vs 491.35 (IQR: 181.1), P: 0.0475). Conclusions: In twice-weekly hemodialysis patients, UA levels above 8 mg/dL were associated with increased SDMA levels. © 2021, Author(s). |
Cardiovascular Risk Factors; Chronic Kidney Disease; Hemodialysis; Hyperuricemia; Uric Acid |
6 n,n' dimethylarginine; uric acid; adult; amino acid blood level; Article; cardiovascular disease; cardiovascular risk factor; cross-sectional study; diabetes mellitus; female; glomerulonephritis; hemodialysis; human; hypertension; major clinical study; male; middle aged; mortality; nutritional assessment; obesity; smoking; tertiary care center; underweight |
Kowsar Medical Institute |
22517006 |
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Article |
Q4 |
150 |
23185 |
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94 |
Subahar R., Susanto L., Aidilla R., Aulia A.P., Yulhasri Y., Winita R., Lubis N.S., Sari I.P. |
6508197883;6507704130;57365800900;57366528800;57225180520;57220782528;57222661567;57197543698; |
In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron microscopic changes in lice |
2021 |
Veterinary World |
14 |
11 |
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3065 |
3075 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120814548&doi=10.14202%2fvetworld.2021.3065-3075&partnerID=40&md5=1d1646983a8b7f7da98a7d4f5896e795 |
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia |
Subahar, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Susanto, L., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Aidilla, R., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Aulia, A.P., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia; Winita, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Lubis, N.S., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia |
Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). Materials and Methods: The adult stages of P. h. capitis were collected from patients exposed to 1% permethrin and three different concentrations of 6-paradol (0.00005%, 0.0001%, and 0.00015%) using a filter paper diffusion bioassay. Healthy P. h. capitis adults served as the control. The in vitro bioassays were conducted after 10, 20, 30, and 60 min of exposure. The activities of acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase were analyzed. Physical changes in the lice were analyzed using SEM. Results: Permethrin and 6-paradol exhibited low toxicity against the lice. At 60 min, 1% permethrin had killed 36.7% of the lice present, while 6-paradol had killed 66.7-86.7%. Permethrin induced significantly elevated AChE, GST, and oxidase activity; 6-paradol also caused significantly elevated AChE, GST, and oxidase activity. Permethrin did not cause any ultrastructural morphological changes on the lice, while 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. Conclusion: This in vitro experimental of P. h. capitis is the first study to report P. h. capitis in East Jakarta shows complete resistance to permethrin and 6-paradol, and to describe the associated increase in AChE, GST, and oxidase activity. It was observed that 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. © 2021 Veterinary World. All rights reserved. |
6-paradol; Detoxifying enzyme; Electron microscopy; Pediculus humanus capitis; Permethrin; Resistance |
6 paradol; acetylcholinesterase; chitin; glutathione transferase; oxidoreductase; permethrin; phenol derivative; unclassified drug; Article; bioassay; controlled study; detoxification; diffusion; enzyme activity; enzyme linked immunosorbent assay; hair loss; LT50; LT90; nonhuman; Pediculus humanus capitis; scanning electron microscopy; ultrastructure |
Veterinary World |
09728988 |
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Article |
Q2 |
550 |
9187 |
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98 |
Yusharyahya S.N., Bramono K., Indriatmi W., Prasetyo M., Ascobat P., Hestiantoro A., Wiraguna A.A.G.P. |
57211780941;9843236700;57189888041;57192905252;55795863600;8743255100;20437026700; |
Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
11 |
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95 |
103 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119480025&doi=10.7324%2fJAPS.2021.1101113&partnerID=40&md5=020217cd5f217dbc98ba3162ac9d99f1 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ascobat, P., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiraguna, A.A.G.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Postmenopausal hypoestrogenism is associated with skin aging, for which phytoestrogen derived from the seeds of Trigonella foenum graecum (fenugreek) is expected to be an alternative solution to reduce wrinkles and increase the thickness of postmenopausal women’s skin. This study was a randomized, double-blind, controlled 12-weeks trial conducted at a general hospital in Jakarta, Indonesia, from January to November 2019. Subjects were 50 postmenopausal women divided into two groups: the intervention group was given 5% fenugreek cream and base cream was given to the placebo group. The results of the independent t-test showed that both groups were able to achieve statistically significant improvement in wrinkle scores on the forehead, crow’s feet, and nasolabial folds which was assessed by photography scoring based on Bazin’s skin aging atlas for Asian skin volume 2 but there was no significant disparity between both groups at all time points. Dermal thickness was assessed by high-resolution ultrasound GE LOGIQ E9 (18 MHz), which showed similar results for both groups with significant improvements in the 8th week compared to baseline and a significant decrease by the 12th week. No significant differences were observed in the skin wrinkle score and skin thickness after the application of fenugreek cream compared to placebo.We suspect that a concentration of 5% was not adequate for the expected antiskin aging effects. Further studies are necessary to determine a more appropriate fenugreek concentration to permit clinical use as an antiskin aging therapy in postmenopausal women. © 2021 Shannaz Nadia Yusharyahya et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License |
Dermal thickness; fenugreek; postmenopausal skin; skin wrinkle |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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99 |
Herawati F., Yulia R., Wiyono H., Massey F.K., Muliani N., Kantono K., Soemantri D., Andrajati R. |
57194722742;56768083700;57321279000;57321051400;57222261946;56580346400;36640659100;9940247700; |
Discordance to ashp therapeutic guidelines increases the risk of surgical site infection |
2021 |
Pharmaceuticals |
14 |
11 |
1088 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118387727&doi=10.3390%2fph14111088&partnerID=40&md5=f3621ba3decf103d84295afa3e55e549 |
Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Food Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Herawati, F., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Yulia, R., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Wiyono, H., Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Massey, F.K., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Muliani, N., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Kantono, K., Department of Food Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand; Soemantri, D., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Andrajati, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia |
Clean surgery without contamination does not require prophylactic antibiotics, but there are high-risk surgical procedures that may cause infection and/or involve vital organs such as the heart, brain, and lungs, and these indeed require the use of antibiotics. This study aimed to determine the quantity of antibiotic use based on the defined daily dose (DDD) per 100 bed days and the quality of antibiotic use based on the percentage of concordance with The American Society of Health-System Pharmacists (ASHP) therapeutic guidelines (i.e., route of administration, time of administration, selection, dose, and duration). This includes the profiles of surgical site infection (SSI) in surgical patients from January through June 2019. The study subjects were 487 surgical patients from two hospitals who met the inclusion criteria. There were 322 patients out of 487 patients who had a clean surgical procedure. Ceftriaxone (J01DD04) was the most used antibiotic, with a total DDD/100 bed days value in hospitals A and B, respectively: pre-surgery: 14.71, 77.65, during surgery: 22.57, 87.31, and postsurgery: 38.34, 93.65. In addition, 35% of antibiotics were given more than 120 min before incision. The lowest concordance to ASHP therapeutic guideline in hospital A (17.6%) and B (1.9%) was antibiotic selection. Two patients experienced SSI with bacterial growths of Proteus spp., Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli. The usage of prophylactic antibiotics for surgical procedures was high and varied between hospitals. Hospital B had significantly lower concordance to antibiotic therapeutic guidelines, resulting to a higher infection rate, compared with hospital A. ASHP adherence components were then further investigated, after which antibiotic dosing interval and injection time was found to be a significant predictor for positive bacterial growth based on logit–logistic regression. Further interventions and strategies to implement antibiotic stewardship is needed to improve antibiotic prescriptions and their use. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Antibiotic stewardship; Defined daily dose; Hospital; Surgical site infection |
amoxicillin; amoxicillin plus clavulanic acid; ampicillin; antibiotic agent; beta lactamase inhibitor; cefadroxil; cefazolin; cefepime; cefixime; cefoperazone; cefotaxime; cefoxitin; ceftazidime; ceftriaxone; chloramphenicol; ciprofloxacin; clindamycin; cotrimoxazole; fosfomycin; gentamicin; levofloxacin; meropenem; metronidazole; moxifloxacin; norfloxacin; ofloxacin; oxacillin; sulbactam; sultamicillin; tetracycline; vancomycin; adult; aged; antibiotic sensitivity; antimicrobial stewardship; Article; bacterial growth; bacterium culture; drug choice; drug use; Escherichia coli; female; human; infection rate; infection risk; intraoperative period; length of stay; major clinical study; male; medical society; middle aged; observational study; postoperative period; practice guideline; preopera |
MDPI |
14248247 |
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Article |
Q1 |
1295 |
2918 |
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100 |
Irawati Y., Paramita C., Daniel H. |
57201260313;57219380835;57316812600; |
Challenging eyelid reconstruction in malignancies: Case reports |
2021 |
Annals of Medicine and Surgery |
71 |
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102987 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118265765&doi=10.1016%2fj.amsu.2021.102987&partnerID=40&md5=d761c9b6bbfe6b7a5a498e07f9e22253 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Paramita, C., Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Daniel, H., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Eye is one of the most crucial organs in need of protection. The most important function of eyelids is designed to protect the eyeball. Despite their small and thin surface area, they are among the most sunlight-exposed area of skins, hence, it is prone to develop eyelid tumors. As the malignant tumors have the tendency of growing aggressively and have a high mortality, we have to meticulously remove the lesion along with its surrounding tissue, if needed, to ensure the clearance of tumor margin. To strike a suitable outcome between the cosmetic and function after tumor removal is a quite challenging task. Compromise on aesthetics and eyelids’ indispensable function of protecting the eyes during management, may lead to unfavorable cosmetic deformity and loss of vision. Therefore, it is imperative that wise selection of appropriate techniques be discussed and managed accordingly. In this article, the authors reported two case scenarios of eyelid reconstruction which was performed to show the management of full-thickness defect after removal of the malignant neoplasms. Skin flaps and graft technique used to reconstruct the eyelid in each patient was different to emphasize that eyelid malignancies require an individualized management. © 2021 |
Eyelid malignancies; Eyelid reconstruction; Full-thickness defect; Skin flaps; Skin graft |
adult,human; Article; case report; clinical article; ectropion; eyelid cancer; eyelid reconstruction; female; follow up; histopathology; human; human tissue; human,clinical article; keratinocyte; lower eyelid; lymph node biopsy; middle aged; muscle graft; palpation; reconstructive surgery; sentinel lymph node biopsy; skin flap; solid mass; squamous cell carcinoma; telangiectasia; tissue flap |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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102 |
Hamid A.R.A.H., Mochtar C.A., Lisnawati, Saraswati M., Matondang S., Affan M.I.F. |
57202054669;6506558321;24449072000;57208472364;57192085914;57312341900; |
Adenocarcinoma mucinosum of extrophy bladder: A rare case report |
2021 |
International Journal of Surgery Case Reports |
88 |
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106493 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117928866&doi=10.1016%2fj.ijscr.2021.106493&partnerID=40&md5=1f53d31ce0245f1e48544663e50eb793 |
Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia |
Hamid, A.R.A.H., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Mochtar, C.A., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Lisnawati, Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Saraswati, M., Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Matondang, S., Department of Radiology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Affan, M.I.F., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Bladder exstrophy is a rare congenital anomaly while, bladder adenocarcinoma mucinous type is a rare type of bladder cancer, with aggressive behavior and inadequate response to radiation and chemotherapy. In extremely rare cases, untreated bladder exstrophy could transform into bladder mucinous adenocarcinoma. Case presentation: We report a case of a 41-year-old male with untreated bladder exstrophy that transformed into mucinous adenocarcinoma. The patient also had epispadias and a right inguinal hernia. Joint procedures were conducted to perform radical cystectomy, total penectomy and W-Pouch continent urostomy, inguinal hernia repair, osteotomy, and keystone and scrotal flap by split-thickness skin graft (STSG) for wound closure. The patient progressed well after surgery, two months after initial procedure, nephrostomies were conducted due to pouches stenosis. Due to the government's limited transportation and lockdown policy, as the Covid-19 pandemic occurred, the patient could not come to the hospital for routine follow-up and died nine-month after surgery. Clinical discussion: Bladder exstrophy is one of the risk factors of bladder cancer. Transformation of bladder exstrophy into mucinous adenocarcinoma is extremely rare, as the case is the first case to be discovered in Indonesia. Surgery, followed with a strict follow-up regime, is mainstay of treatment in this type of malignancy. Conclusion: Adenocarcinoma of mucinous type is a scarce type of bladder exstrophy malignancies. A multidiscipline approach is mandatory in these cases. Strict and regular follow up are suggested for these cases. © 2021 The Authors |
Bladder exstrophy; Epispadias; Inguinal hernia; Mucinous adenocarcinoma |
creatinine; adult; Article; bladder carcinoma; bladder exstrophy; case report; clinical article; colloid carcinoma; coronavirus disease 2019; creatinine blood level; cystectomy; echography; epispadias; excisional biopsy; hernioplasty; histopathology; human; human tissue; hydronephrosis; hydroureter; inguinal hernia; inguinal region; interstitial cystitis; lockdown; male; malignant transformation; multidisciplinary team; nephrostomy; pandemic; pelvis radiography; penis amputation; split thickness skin graft; surgical mortality; wide excision; wound closure; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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104 |
Rustamadji P., Wiyarta E., Anggraeni T.D., Siregar T.P. |
55321572200;57221521342;57192894826;57222017915; |
Adult granulosa cell tumor with minor foci of juvenile granulosa cell tumor in postmenopausal woman: A rare case report |
2021 |
International Journal of Surgery Case Reports |
88 |
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106531 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117387663&doi=10.1016%2fj.ijscr.2021.106531&partnerID=40&md5=b928e465d23286856e05bfdba88bbaad |
Department of Pathological Anatomy, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta 10430, Indonesia; Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia |
Rustamadji, P., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta 10430, Indonesia; Anggraeni, T.D., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia; Siregar, T.P., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia |
Introduction: Granulosa cell tumor (GCT) is a rare neoplasm that is divided into adult GCT (AGCT) and juvenile GCT (JGCT). Generally, a patient will only have the AGCT or JGCT subtypes. Here, we presented the first case of AGTC accompanied by focal JGTC in a postmenopausal woman. Presentation of case: A 63-year-old postmenopausal woman came with distended abdomen accompanied by postmenopausal bleeding. CT scan shows a solid mass with cystic degeneration. Laparotomy found a solid mass from the right ovary measuring 18 × 15 × 14 cm. The pathological results showed a diffuse tumor representing AGCT, accompanied by Call-Exner bodies and nuclear groove. In addition, minor foci were also found, which consist of well-defined margins tumor and follicular-like structures that resemble JGCT. The patient underwent bilateral salpingo-oophorectomy with a total hysterectomy and no recurrence in three months follow-up. Discussion: Age and clinical symptoms cannot be used as specific differentiators between AGTC and JGTC. Radiological imaging also shows a similar appearance of solid masses tumors with hemorrhagic or fibrotic changes, multilocular cystic lesions, or completely cystic tumors. The concomitant findings of JGCT and AGCT could be distinguished very carefully by anatomical pathology examination. It is crucial to differentiate AGCT from JGCT, especially to see the prognosis. Conclusion: The role of pathologists is needed in differentiating AGCT and JGCT, primarily when found simultaneously. © 2021 |
Granulosa cell tumor; Menopause; Ovarium tumor; Pathology; Rare case |
abdominal distension; abdominal radiography; adult; adult disease; Article; ascites; bilateral salpingo-oophorectomy; cancer tissue; case report; cell proliferation; clinical article; contrast enhancement; defecation; drug use; echography; female; follow up; frozen section; granulosa cell; granulosa cell tumor; human; hysterectomy; hysteroscopy; inflammatory cell; International Federation of Gynecology and Obstetrics; juvenile granulosa cell tumor; laboratory test; laparotomy; micturition; middle aged; mitosis; mobilization; myometrium; physical examination; postmenopause; postmenopause bleeding; treatment planning; tumor volume; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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106 |
Tobing S.D.A.L., Hendriarto A., Wikanjaya R. |
57192893142;57216821517;57211909508; |
Conservative approach for treatment of Grisel's syndrome after resection of lympahadenitis tuberculosis of the neck: A rare case report |
2021 |
International Journal of Surgery Case Reports |
88 |
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106452 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116936259&doi=10.1016%2fj.ijscr.2021.106452&partnerID=40&md5=a61504c984a695791169d7a4a2464b5f |
Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tobing, S.D.A.L., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hendriarto, A., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wikanjaya, R., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Grisel's syndrome is a rare condition characterized by nontraumatic rotatory subluxation of the atlantoaxial joint, which was caused by previous inflammation around the head and neck. It is usually seen in children and signed as torticollis. There was no consensus for management, yet early diagnosis and treatment is paramount. Presentation of case: A 5-year-old girl came to outpatient clinic complaining of wry neck 1 day after surgical excision of her TB lymphadenitis and got worsen by time. There was no history of trauma around the neck. Examination under general anesthesia and CT scan revealed acquired severe torticollis consistent with Grisel's Syndrome Fielding type 3 accompanied by TB lymphadenitis, and TB myositis of the neck. Manipulation under general anesthesia and immobilization using Minerva cast followed by Lerman Cervicothoracal Osthosis was conducted. Discussion: This patient was diagnosed with Grisel's syndrome and underwent conservative treatment consisting of reduction under general anesthesia and immobilization using Minerva cast for 6 weeks. The patient was then applied Lherman Cervical Thoracic Orthosis (CTO) halo brace for another 3 months. Anti-tuberculous drug was given to control tuberculous infection. Eight months follow-up showed neither residual deformity, neck pain, nor movement limitation of the neck. Conclusion: Grisel's syndrome has excellent result that is treated with conservative treatment using reduction under general anesthesia and Minerva cast. © 2021 The Authors |
Acquired torticollis; Conservative; Grisel's syndrome; Minerva cast |
cobamamide; cyproheptadine; tuberculostatic agent; Article; atlantoaxial subluxation; body weight gain; case report; cervical lymph node; child; clinical article; computer assisted tomography; conservative treatment; disease exacerbation; excision; excisional biopsy; female; fever; follow up; general anesthesia; Grisel syndrome; headache; histopathology; hoarseness; human; human tissue; immobilization; infection control; interferon gamma release assay; Langhans giant cell; loss of appetite; lymphadenitis; myositis; nausea; neck malformation; neuroimaging; night sweat; nuclear magnetic resonance imaging; outpatient department; physical examination; preschool child; puncture; range of motion; sternocleidomastoid muscle; torticollis; tuberculin test; tuberculous lymphadenitis |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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107 |
Poerbonegoro N.L., Reksodiputro M.H., Sari D.P., Mufida T., Rahman M.A., Reksodiputro L.A., Audindra S., Yosia M. |
57222574894;35090488800;57292553600;57291865900;57291413400;57292781100;57222006228;57204933098; |
Cross-sectional study on the proportion of smell and taste disturbances in hospitalized COVID-19 patients |
2021 |
Annals of Medicine and Surgery |
71 |
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102909 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116899241&doi=10.1016%2fj.amsu.2021.102909&partnerID=40&md5=96e678393268c92055e16d284f8c40f7 |
Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Poerbonegoro, N.L., Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia; Reksodiputro, M.H., Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia; Sari, D.P., Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia; Mufida, T., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rahman, M.A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, L.A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Audindra, S., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yosia, M., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: The number of confirmed Coronavirus Disease-2019 (COVID-19) cases in Indonesia had reached 1.4 million cases from a total population of 270 million. Smell and/or taste disturbances are frequently found as early symptoms of COVID-19 patients. Our study aimed to investigate the proportion and characteristics of anosmia and/or ageusia in COVID-19. Materials and methods: This cross-sectional study identifies the proportion and severity of smell and taste disturbances in COVID-19 patients. Subjects were recruited by consecutive sampling. All subjects were required to fill in the questionnaire modified from the American Academy of Otolaryngology-Head and Neck Surgery Anosmia Reporting Tool (AAO-HNS ART). Symptoms severity was measured with a numerical rating scale of 0–10; 0–3 is defined as mild, 4–6 as moderate, and 7–10 as severe. Results: Out of 51 subjects, 34 (66.7%) suffered from smell and/or taste disturbances. Twenty-nine of 34 subjects (85.3%) suffered from smell disturbance, and 24 of 34 subjects (70.5%) suffered from taste disturbance. Severe smell disturbance occurred in 68.9% of subjects, while severe taste disturbance occurred in 50%. The median onset was three days for smell disturbance and four days for taste disturbance after any symptoms of COVID-19. Conclusion: Smell and/or taste disturbances were early symptoms of COVID-19. These symptoms commonly occurred within the first four days of clinical onset and frequently manifested in severe conditions. © 2021 |
Ageusia; Anosmia; COVID-19; Indonesia |
adult; American Academy of Otolaryngology Head and Neck Surgery Anosmia Reporting Tool; Article; coronavirus disease 2019; cross-sectional study; disease assessment; disease severity; female; human; major clinical study; male; numeric rating scale; questionnaire; real time polymerase chain reaction; retrospective study; risk factor; smelling disorder; taste disorder; visual analog scale |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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111 |
Baskoro J.C., Hadi I.A.N., Ekaputri M., Winarsih N.S. |
57242005500;57242308100;57242005600;57211183552; |
Correlation between duration of untreated psychosis and working memory in early-onset psychotic disorders |
2021 |
Personalized Medicine in Psychiatry |
29-30 |
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100084 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114078676&doi=10.1016%2fj.pmip.2021.100084&partnerID=40&md5=56d11228ab6c85aba3075e3f4f99e800 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia |
Baskoro, J.C., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia; Hadi, I.A.N., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia; Ekaputri, M., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia; Winarsih, N.S., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia |
Psychotic disorders are morbid mental disorders that impair working memory. Theory suggests that longer duration of untreated psychosis (DUP) results in worse working memory. However, results from previous studies are contradictory, with no study having been conducted in children. This study aims at finding out the association between duration of untreated psychosis and working memory in children. This is a cross-sectional study with 45 subjects. DUP was collected from medical records whereas working memory was measured using digit span backward raw score. Average digit span backward scores of subjects was 3.7 ± 1.18. Analysis using Spearman test showed no significant association (p = 0.128) between DUP and working memory. In conclusion, there is no association between DUP and working memory in children, therefore we recommend that psychiatrists pay attention to working memory impairment in all pediatric patients with psychotic disorders, regardless of their DUP. © 2021 Elsevier Inc. |
Children; Duration of untreated psychosis; Psychosis; Working memory |
neuroleptic agent; acute psychosis; adolescent; adult; Article; attention; child; child psychiatry; clinical article; clinical assessment; clinical feature; controlled study; correlation analysis; cross-sectional study; digit span backward raw score; disease association; disease duration; duration of untreated psychosis; female; human; male; medical record; medication compliance; memory test; outcome assessment; patient compliance; pediatric patient; psychosis; schizophrenia; treatment duration; working memory |
Elsevier Inc. |
24681717 |
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