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Auer S., Haelterman N.A., Weissgerber T.L., Erlich J.C., Susilaradeya D., Julkowska M., Gazda M.A., Schwessinger B., Jadavji N.M., Abitua A., Niraulu A., Shahb A., Clyburne-Sherinb A., Guiquel B., Alicea B., Lamanna C., Ganguly D., Perkins E., Jambor H., Li I.M.H., Tsang J., Kamens J., Teytelman L., Paul M., Cronin M., Schmelling N., Crisp P., Kutum R., Phuyal S., Sarabipour S., Roy S., Bachle S.M., Tran T., Ford T., Steeves V., Ilangovan V., Baburamani A., Bachle S. |
57224755481;43961196400;6506688349;54396932600;57208325289;54787902500;57194268384;24438486300;8866064800;57224999223;57224994032;57224999963;57224992543;57224993799;51563211500;57225409050;56514870300;57224997775;25421754600;57224994090;57224992895;57224995287;57205247619;57216221631;57224995069;57193626389;36933973000;56871221600;55388614600;16053538000;57224999908;55516154900;57224994106;57224992308;57092624000;57216037751;26867552100;55516154900; |
Science forum: A community-led initiative for training in reproducible research |
2021 |
eLife |
10 |
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e64719 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108881951&doi=10.7554%2feLife.64719&partnerID=40&md5=86ee0e85a4e402a7d89730773f6396b8 |
Department of Plant Physiology, Institute of Botany, Faculty of Biology, TU Dresden, Dresden, Germany; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center, Berlin, Germany; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China; Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Boyce Thompson Institute, United States; CIBO/InBIOO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Portio, Campus Agrário de Vairão, Porto, Portugal; Departamento de Biologia, Faculdade de Ciências, Universidade do Portio, Porto, Portugal; Research School of Biology, Australian National University, Canberra, Australia; Department of Biomedical Science, Midwestern University, Glendale, United States; Addgene, Boston, United States; Neuroscience Graduate Program, Ohio State UniversityOH, United States; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; Reproducibility for EveryoneNY, United States; Addgene, London, United Kingdom; Orthogonal Research and Education Laboratory, Champaign, United States; Research School of Biology, Australian National University, Canberra, Australia; Centre for Regenerative Therapies Dresden, Dresden, Germany; Massachusetts General Hospital, Harvard University, Boston, United States; Protocols.io, San Francisco, United States; Psychology of Language Group, University of Gottingen, Gottingen, Germany; Institute for Synthetic Microbiology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Plant Biotechnology, Tennessee State University, Nashville, United States; School of Mechanical & Aerospace Engineering, Nanyang Technological University, Nanyang, Singapore; Picture as Portal, San Francisco, United States; Research Data Management and Reproducibility, New York UniversityNY, United States; Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; Centre for the Development of Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom; Department of Neuroscience, Carleton University, Ottawa, Canada |
Auer, S., Department of Plant Physiology, Institute of Botany, Faculty of Biology, TU Dresden, Dresden, Germany; Haelterman, N.A., Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States; Weissgerber, T.L., Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center, Berlin, Germany; Erlich, J.C., NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai, China; Susilaradeya, D., Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Julkowska, M., Boyce Thompson Institute, United States; Gazda, M.A., CIBO/InBIOO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Portio, Campus Agrário de Vairão, Porto, Portugal, Departamento de Biologia, Faculdade de Ciências, Universidade do Portio, Porto, Portugal; Schwessinger, B., Research School of Biology, Australian National University, Canberra, Australia; Jadavji, N.M., Department of Biomedical Science, Midwestern University, Glendale, United States, Department of Neuroscience, Carleton University, Ottawa, Canada; Abitua, A., Addgene, Boston, United States; Niraulu, A., Neuroscience Graduate Program, Ohio State UniversityOH, United States; Shahb, A., The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; Clyburne-Sherinb, A., Reproducibility for EveryoneNY, United States; Guiquel, B., Addgene, London, United Kingdom; Alicea, B., Orthogonal Research and Education Laboratory, Champaign, United States; Lamanna, C., Addgene, Boston, United States; Ganguly, D., Research School of Biology, Australian National University, Canberra, Australia; Perkins, E., Addgene, Boston, United States; Jambor, H., Centre for Regenerative Therapies Dresden, Dresden, Germany; Li, I.M.H., Massachusetts General Hospital, Harvard University, Boston, United States; Tsang, J., Addgene, Boston, United States; Kamens, J., Addgene, Boston, United States; Teytelman, L., Protocols.io, San Francisco, United States; Paul, M., Psychology of Language Group, University of Gottingen, Gottingen, Germany; Cronin, M., Addgene, Boston, United States; Schmelling, N., Institute for Synthetic Microbiology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany; Crisp, P., Research School of Biology, Australian National University, Canberra, Australia; Kutum, R., Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Phuyal, S., Institute of Basic Medical Science, University of Oslo, Oslo, Norway; Sarabipour, S., Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; Roy, S., Plant Biotechnology, Tennessee State University, Nashville, United States; Bachle, S.M., Addgene, Boston, United States, Addgene, Boston, United States; Tran, T., School of Mechanical & Aerospace Engineering, Nanyang Technological University, Nanyang, Singapore; Ford, T., Picture as Portal, San Francisco, United States; Steeves, V., Research Data Management and Reproducibility, New York UniversityNY, United States; Ilangovan, V., Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; Baburamani, A., Centre for the Development of Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom; Bachle, S., Addgene, Boston, United States, Addgene, Boston, United States |
Open and reproducible research practices increase the reusability and impact of scientific research. The reproducibility of research results is influenced by many factors, most of which can be addressed by improved education and training. Here we describe how workshops developed by the Reproducibility for Everyone (R4E) initiative can be customized to provide researchers at all career stages and across most disciplines levels and across disciplines with education and training in reproducible research practices. The R4E initiative, which is led by volunteers, has reached more than 2000 researchers worldwide to date, and all workshop materials, including accompanying resources, are available under a CC-BY 4.0 license at www.repro4everyone.org. © 2021, eLife Sciences Publications Ltd. All rights reserved. |
Accessible protocols; FAIR data; Reproducibility; Rigor; Transparency; Transparent data processing |
biomaterial; Article; bioinformatics; FAIR principles; reproducibility; software; training; education; human; medical research; methodology; personnel; procedures; reproducibility; Biomedical Research; Humans; Reproducibility of Results; Research Design; Research Personnel |
eLife Sciences Publications Ltd |
2050084X |
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34151774 |
Article |
Q1 |
5879 |
219 |
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380 |
Kurniawan R., Nur R.J.B., Yuliyanti S., Nuridzin D.Z., Kartinah N.T. |
57189681782;57222637045;57222633264;57222637716;57192914846; |
Healthy family index assessment through community-based health information system approach |
2021 |
International Journal of Public Health Science |
10 |
2 |
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394 |
400 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103597839&doi=10.11591%2fijphs.v10i2.20751&partnerID=40&md5=fe1ac4f92382153c62ee102a2fadb48f |
Department of Biostatistic and Population Study, Faculty of Public Health, Universitas Indonesia, Indonesia; Research Center for Biostatistics and Health Informatics, Faculty of Public Health, Universitas Indonesia, Indonesia; Department of Physiology Pre-Clinic, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kurniawan, R., Department of Biostatistic and Population Study, Faculty of Public Health, Universitas Indonesia, Indonesia; Nur, R.J.B., Research Center for Biostatistics and Health Informatics, Faculty of Public Health, Universitas Indonesia, Indonesia; Yuliyanti, S., Research Center for Biostatistics and Health Informatics, Faculty of Public Health, Universitas Indonesia, Indonesia; Nuridzin, D.Z., Research Center for Biostatistics and Health Informatics, Faculty of Public Health, Universitas Indonesia, Indonesia; Kartinah, N.T., Department of Physiology Pre-Clinic, Faculty of Medicine, Universitas Indonesia, Indonesia |
The healthy Indonesia program with a family approach (PIS-PK) has not been implemented optimally. There are several obstacles and challenges in this program’s implementation, e.g., human resources. A community-based health information system (CBHIS) is a strategic approach to obtain data and information at the population level by directly involving cadres and the community. A project with the CBHIS approach was implemented in Kasemen Village, Serang, Banten Province, Indonesia to support the PIS-PK program. The study aimed to determine the population’s health status according to the healthy family index through the CBHIS approach. The data of healthy family indicators in the village were collected by cadres using a mHealth application. Overall, 1316 households consisting of 5312 residents were registered. The analysis results of the healthy family index showed that most families in the Kasemen subdistrict were pre-healthy (64.2%), almost one third were unhealthy (27.8%) and only a small proportion were healthy (8%). Assessing the healthy family index through the CBHIS approach can support decision-making at the community level, thereby determining the magnitude of family health problems and providing appropriate interventions to improve community health status. Well-trained cadres equipped with better electronic data collection tools may be an alternative to community-based data collection. © 2021, Institute of Advanced Engineering and Science. All rights reserved. |
Community-based; Family approach; Health information system; Healthy family index |
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Institute of Advanced Engineering and Science |
22528806 |
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Article |
#N/A |
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381 |
Chikih C., Suryokusumo G., Sulistomo A. |
57222637163;57205444996;57024018500; |
Effect of acute submaximal physical exercise before decompression dive on tumor necrosis factor alpha concentration among male trained divers |
2021 |
International Journal of Public Health Science |
10 |
2 |
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289 |
297 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103567616&doi=10.11591%2fijphs.v10i2.20666&partnerID=40&md5=8c8626032d01ce9797442118fb643071 |
Postgraduate Program Occupational Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Klinik Hijau Putih 29, Primary Health Care Provider, Indonesia |
Chikih, C., Postgraduate Program Occupational Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Klinik Hijau Putih 29, Primary Health Care Provider, Indonesia; Suryokusumo, G., Postgraduate Program Occupational Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Sulistomo, A., Postgraduate Program Occupational Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia |
The increase of inflammatory biomarkers due to decompression dive is one of the factors that could cause decompression sickness (DCS), one of them is tumor necrosis alpha (TNFα). According to the preconditioning theory, exercise before dive can reduce amount of gas bubble to prevent DCS. This study aimed to prove that exercise before diving can prevent increase of TNFα. This study employed quasi-experimental design with trained male divers. The subject divided into two groups, treatment and control. The treatment group got submaximal exercise with 70% heart rate intensity, using cycle ergometer with young men's Christian association (YMCA) procedure modify by Guritno, 24 hours before decompression dive 280 kPa bottom time 80 minute with US-NAVY table, whereas the control group only do decompression dive. TNFα expression was checked three times, at beginning of study, before dive and after dive. In treatment group there was insignificant decrease TNFα, from 7.06±1.85pg./ml to 6.75±1.81pg./ml, whereas the control group showed a significant increased TNFα, from 8.22 (1.45 to 13.11)pg./ml to 8.39 (1.73 to 12.18)pg/ml, and significant difference was found between the mean difference for two groups p<0.05. It can be concluded that acute submaximal exercise prevents an increase of TNFα after single dive decompression to prevent possibility occurring DCS). © 2021, Institute of Advanced Engineering and Science. All rights reserved. |
Decompression dive; Physical exercise; Preconditioning; Prevention of DCS; TNFα |
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Institute of Advanced Engineering and Science |
22528806 |
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Article |
#N/A |
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428 |
Soetisna T.W. |
57214887740; |
A new hope of cd133+ bone marrow stem cell for functional exercise capacity improvement in low ejection fraction coronary artery bypass graft patients: A clinical trial |
2021 |
Bali Medical Journal |
10 |
1 |
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229 |
233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106002523&doi=10.15562%2fbmj.v10i1.2255&partnerID=40&md5=80046a217774aa6ef82836d9a524c4ff |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Patients with low ejection fraction who are undergoing coronary artery bypass graft (CABG) only have an insignificant improvement in ejection fraction. This condition will make a little hope to achieve an improvement in physical performance. But now, from a view study, CD133+ stem cells offer new hope for this situation. This study evaluates CD133+ bone marrow stem cells’ role for functional exercise capacity improvement in low ejection fraction coronary artery bypass graft patients. Methods: Thirty patients with ischemic heart disease who had ejection fraction<35% at the National Cardiovascular Center were randomized into 2 groups. The treatment group undergoes the CABG + CD133+ procedure and the control group undergoes the CABG only. All research subjects underwent follow-up before and 6 months after the procedure. Fraction ejection, scar size, wall motion score index, ventricular dimensions, myocardial perfusion measured by cardiac MRI, 6 Minutes Walking Test (6MWT) and Minnesota Living with Heart Failure Questionnaire (MLHFQ) as an additional parameter for physical performance and quality of life. Data was analyzed using SPSS version 21 for Windows. Results: The results of the fraction ejection parameters showed a significant improvement in the treatment group, from 25.88±5.66% to 34.57%±11.31% compared to CABG only 30.18±3.85% to 31.61±7.89% (p=0.040), in the perfusion defect showed improvement but not significant, left ventricular end-systolic volume and left ventricular end-diastolic volume showed improvement with no significant result, scar size was found to be an improvement in the treatment group 10 persons (76.92%) compared to the control group 5 persons (38, 46%) (p=0.040), the wall motion score index and 6MWT showed a significant improvement in the treatment group (p=0.003 and p=0.03, respectively). The MLHFQ parameter showed improvement but not significant. Conclusion: CD 133+ stem cell implantation in patients with low ejection fraction who undergo CABG provides improved myocardial function and indirectly improves functional exercise capacity and patients’ quality of life. © 2021, Sanglah General Hospital. All rights reserved. |
CABG; CD133+ Stem cell; Functional exercise capacity |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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451 |
Christian, Puruhita N., Himawan A., Muis S.F., Fasitasari M., Pangarsa E.A., Panigoro S.S., Sutandyo N. |
57224896360;57224902090;57224910728;57193264578;57192872474;57204907532;56790104300;26028099200; |
Fat intake in Javanese breast cancer patients: Any difference? |
2021 |
Bali Medical Journal |
10 |
1 |
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320 |
324 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108565233&doi=10.15562%2fbmj.v10i1.2173&partnerID=40&md5=7840397cf684896b0d8d5929cbb1e87c |
Resident of Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Faculty of Medicine, Universitas Islam Sultan Agung-Sultan Agung Islamic Hospital Semarang, Indonesia; Hematology-Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Oncology Surgery Division, Surgery Department, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hematology-Oncology Division, Internal Medicine Department, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia |
Christian, Resident of Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Puruhita, N., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Himawan, A., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Muis, S.F., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Fasitasari, M., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Faculty of Medicine, Universitas Islam Sultan Agung-Sultan Agung Islamic Hospital Semarang, Indonesia; Pangarsa, E.A., Hematology-Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Panigoro, S.S., Oncology Surgery Division, Surgery Department, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Sutandyo, N., Hematology-Oncology Division, Internal Medicine Department, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia |
Background: Breast cancer is the second most prevalent women’s malignancy in Central Java. The risk of breast cancer incidence drops by 2.5 times for breast cancer if fat consumption is reduced by 50%, although not all types of fat intake increase the risk of breast cancer incidence. Fat consumption in Indonesia increased by 11% in the last 7 years. The study aims to analyze the differences in fat intake between breast cancer subjects and healthy subjects. Methods: This study is a cross-sectional study. We invited 45 outpatients diagnosed with breast cancer in Kariadi Hospital from January to August 2019 as well as 45 healthy subjects who are relatives or friends of the patients who met the inclusion criteria to participate in this study. Various types of fat intake were measured with quantitative food frequency questionnaires. The statistical analysis employed a chi-square test and Mann-Whitney test for non-parametric tests and an independent t-test for parametric data. Results: There was a significant difference in polyunsaturated fatty acid (PUFA) intake between breast cancer patients and healthy subjects (p=0.022). This study found no significant differences in total fat intake (p=0.677), saturated fatty acid (SFA) (p=0.368), monounsaturated fatty acid (MUFA) (p=0.593), omega 3 (p=0.095), omega 6 (p=0.092), and TFA (p=0.669) between breast cancer patients and healthy subjects. Conclusion: There is a significant difference in PUFA intake, but not in the other types of fat between breast cancer patients and healthy subjects. For further study, more precise and objective fat intake measurements may be achieved in studies with animal models. © 2021, Sanglah General Hospital. All rights reserved. |
Breast cancer; Fat; Intake; Nutrition |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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467 |
Miftahussurur M., Doohan D., Syam A.F., Nusi I.A., Subsomwong P., Waskito L.A., Maulahela H., Akil F., Uwan W.B., Siregar G., Fauzia K.A., Rezkitha Y.A.A., Rahman A., Wibawa I.D.N., Saudale A.M.J., Richardo M., Sugihartono T., Chomariyati A., Bramantoro T., Uchida T., Yamaoka Y. |
56323903000;57204644036;8443384400;56543515200;57113712700;57192177367;57189612709;35191671700;57093988500;56483277100;57204649404;56543533600;57212819255;6504449940;57192179505;57207621686;57194156387;57222871823;57196010143;35286123100;55183784100; |
Cyp2c19 polymorphisms in indonesia: Comparison among ethnicities and the association with clinical outcomes |
2021 |
Biology |
10 |
4 |
300 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104101307&doi=10.3390%2fbiology10040300&partnerID=40&md5=5c1d7696c67d83bbcf546211d5004bf0 |
Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Center of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Department of Internal Medicine, Santo Antonius Hospital, Pontianak, 78243, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, 60113, Indonesia; Department of Internal Medicine, Kolaka General Hospital, Kolaka, 93511, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Udayana, Denpasar, 80232, Indonesia; Department of Internal Medicine, Prof. Dr. W. Z. Johannes General Hospital, Kupang, 85111, Indonesia; Department of Internal Medicine, Merauke City General Hospital, Merauke, 99613, Indonesia; Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia; Department of Molecular Pathology, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, 879-5593, Japan; Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, United States |
Miftahussurur, M., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Syam, A.F., Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Nusi, I.A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Subsomwong, P., Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan, Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Waskito, L.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Akil, F., Center of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Uwan, W.B., Department of Internal Medicine, Santo Antonius Hospital, Pontianak, 78243, Indonesia; Siregar, G., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, 60113, Indonesia; Rahman, A., Department of Internal Medicine, Kolaka General Hospital, Kolaka, 93511, Indonesia; Wibawa, I.D.N., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Udayana, Denpasar, 80232, Indonesia; Saudale, A.M.J., Department of Internal Medicine, Prof. Dr. W. Z. Johannes General Hospital, Kupang, 85111, Indonesia; Richardo, M., Department of Internal Medicine, Merauke City General Hospital, Merauke, 99613, Indonesia; Sugihartono, T., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Chomariyati, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Bramantoro, T., Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia; Uchida, T., Department of Molecular Pathology, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Yamaoka, Y., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan, Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, 879-5593, Japan, Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, United States |
CYP2C19 polymorphisms are important factors for proton pump inhibitor-based therapy. We examined the CYP2C19 genotypes and analyzed the distribution among ethnicities and clinical outcomes in Indonesia. We employed the polymerase chain reaction-restriction fragment length polymorphism method to determine the CYP2C19 genotypes and evaluated inflammation severity with the updated Sydney system. For CYP2C19*2, 46.4% were the homozygous wild-type allele, 14.5% were the homozygous mutated allele, and 39.2% were the heterozygous allele. For CYP2C19*3, 88.6% were the homozygous wild-type allele, 2.4% were the homozygous mutated allele, and 9.0% were the heterozygous allele. Overall, the prevalence of rapid, intermediate, and poor metabolizers in Indonesia was 38.5, 41.6, and 19.9%, respectively. In the poor metabolizer group, the frequency of allele *2 (78.8%) was higher than the frequency of allele *3 (21.2%). The Papuan had a significantly higher likelihood of possessing poor metabolizers than the Balinese (OR 11.0; P = 0.002). The prevalence of poor metabolizers was lower compared with the rapid and intermediate metabolizers among patients with gastritis and gastroesophageal reflux disease. Intermediate metabolizers had the highest prevalence, followed by rapid metabolizers and poor metabolizers. Dosage adjustment should therefore be considered when administering proton pump inhibitor-based therapy in Indonesia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
CYP2C19; Gastritis; H. pylori; Infectious disease; Polymorphism |
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MDPI AG |
20797737 |
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Article |
Q1 |
1731 |
1747 |
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603 |
Clarissa A., Sutandi N., Fath A.A. |
57201653912;57201654034;57257442900; |
Stem-Cell Therapy Following High-Dose Chemotherapy in Advanced Retinoblastoma: A Systematic Review |
2021 |
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) |
10 |
4 |
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397 |
407 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114846321&doi=10.1097%2fAPO.0000000000000372&partnerID=40&md5=bd9b021766dfa6bd6c9f108c62bd4c7c |
Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Clarissa, A., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Sutandi, N.; Fath, A.A. |
PURPOSE: To analyze the risk and benefit of high-dose chemotherapy followed by stem cell transplantation (HDCT-SCT) treatment in patients with advanced retinoblastoma. DESIGN: Systematic review. METHODS: A comprehensive literature search from 4 online databases, including PubMed, Scopus, EBSCO, and Cochrane was done for original studies evaluating the use of HDCT followed by SCT in the treatment of patients with advanced retinoblastoma. The last search was performed on April 15, 2020. RESULTS: A total of 35 studies consisting of 160 patients were considered suitable for inclusion. After HDCT-SCT treatment, 108/160 (67.5%) patients were alive with no evidence of disease at the last follow-up. The incidence of secondary malignancy in our data was also relatively low, which was 16/160 (10%) patients. The side effects were mainly hematological and gastrointestinal toxicities. The prognosis for metastatic cases especially the one to the central nervous system (CNS) remains poor, as shown in our data that 22 of 44 (50%) patients died due to the evidence of disease, and 12 of 44 (27%) patients acquired CNS relapse and died. CONCLUSIONS: HDCT-SCT is a promising treatment option in patients with advanced retinoblastoma. The use of HDCT-SCT in CNS metastases needs to be carefully considered, possibly by adding thiotepa or topotecan to improve tumor control. Further randomized clinical trials are needed to draw firm conclusion regarding its safety and efficacy. Copyright © 2021 Asia-Pacific Academy of Ophthalmology. Published by Wolters Kluwer Health, Inc. on behalf of the Asia-Pacific Academy of Ophthalmology. |
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antineoplastic agent; human; multimodality cancer therapy; retina tumor; retinoblastoma; stem cell transplantation; tumor recurrence; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Humans; Neoplasm Recurrence, Local; Retinal Neoplasms; Retinoblastoma; Stem Cell Transplantation |
NLM (Medline) |
21620989 |
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33481395 |
Article |
#N/A |
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636 |
Wardhani S.O., Fajar J.K., Soegiarto G., Wulandari L., Maliga H.A., Ilmawan M., Merysa R., Simamora A.B., Aini Q., Noviantari K., Lestari A.W., Harnila M.Y., Syafi'i I., Djianzonie J.A.C., Siagian N., Nining S., Hanim R.Z., Wahyuni W., Aulia F., Juliansyah J., Mahmud R., Tamara F., Mahendra A.I., Wowor A.C., Baladraf F., Hadinata P.H., Ikkeputri A., Nadya H., Kartini D.A., Husnah M., Nainu F., Harapan H. |
57193196381;56156139600;57193717004;52464692000;57222334227;57217182580;57412905100;57413600800;57413736700;57412771300;57413600900;57413601000;57412905200;57221505199;57343359200;57413601100;57413182200;57436727400;57413458400;57412905300;57413049000;57192950403;57202301766;57413182300;57412771400;57412905400;57412771500;57413601200;57223337784;57194724156;57120069200;55844857500; |
The association between therapeutic plasma exchange and the risk of mortality among patients critically ill with COVID-19: A meta-analysis. |
2021 |
F1000Research |
10 |
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1280 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122857082&doi=10.12688%2ff1000research.74972.1&partnerID=40&md5=538e74eb0948ed728ed9150f0537f262 |
Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Universitas Indonesia, Jakarta, s10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Wardhani, S.O., Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Soegiarto, G., Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Merysa, R., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Simamora, A.B., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Aini, Q., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Noviantari, K., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Lestari, A.W., Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Harnila, M.Y., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Syafi'i, I., Faculty of Pharmacy, Universitas Indonesia, Jakarta, s10430, Indonesia; Djianzonie, J.A.C., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Siagian, N., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Nining, S., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Hanim, R.Z., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Wahyuni, W., Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Aulia, F., Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Juliansyah, J., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Mahmud, R., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Wowor, A.C., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Baladraf, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Hadinata, P.H., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Ikkeputri, A., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Nadya, H., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Kartini, D.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Husnah, M., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Background: Cytokine storm has been widely known to contribute to the development of the critical condition in patients with coronavirus disease 2019 (COVID-19), and studies had been conducted to assess the potential aspect of cytokine storm elimination by performing therapeutic plasma exchange (TPE). However, contradictory findings were observed. The objective of this study was to assess the association between TPE and the reduction of mortality of critically ill COVID-19 patients. Methods: A meta-analysis was conducted by collecting data from PubMed, Scopus, and Web of Science. Data on the mortality rate of critically ill COVID-19 patients treated with TPE plus standard of care and that of patients treated with standard of care alone were analyzed using a Z test. Results: We included a total of four papers assessing the association between TPE and the risk of mortality among critically ill COVID-19 patients. Our findings suggested that critically ill COVID-19 patients treated with TPE had lower risk of mortality compared to those without TPE treatment. Conclusion: Our study has identified the potential benefits of TPE in reducing the risk of mortality among critically ill COVID-19 patients. © 2021 Wardhani SO et al. |
COVID-19therapeutic plasma exchangecytokine stormtreatment |
coronavirus disease 2019; critically ill patient; cytokine storm; human; meta analysis; mortality rate; plasma exchange; Review; systematic review; critical illness; cytokine release syndrome; plasma exchange; COVID-19; Critical Illness; Cytokine Release Syndrome; Humans; Plasma Exchange; SARS-CoV-2 |
F1000 Research Ltd |
20461402 |
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35083038 |
Review |
Q1 |
1099 |
3793 |
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659 |
Dewi S., Yulhasri Y., Mulyawan W. |
57192904541;57225180520;57192910410; |
The Impact of Intermittent Hypobaric Hypoxia Exposures on Triacylglycerol Synthesis in Rat Liver |
2021 |
Reports of Biochemistry and Molecular Biology |
10 |
3 |
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437 |
444 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120058392&partnerID=40&md5=0ff2179c774f4a9d0d0a1c462ec80dc4 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Aerophysiology, Lakespra Saryanto, Air Force Indonesian National Army, Jakarta, Indonesia |
Dewi, S., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mulyawan, W., Department of Aerophysiology, Lakespra Saryanto, Air Force Indonesian National Army, Jakarta, Indonesia |
Background: In a hypoxic state, fatty acid breakdown reaction may be inhibited due to a lack of oxygen. It is likely that the fatty acids will be stored as triacylglycerol. The aim of this study was to analyse triacylglycerol synthesis in the liver after intermittent hypobaric hypoxia (HH) exposures. Methods: Samples are liver tissues from 25 male Wistar rats were divided into 5 groups: controlgroup (normoxia), group I (once HH exposure), group II (twice HH exposures), group III (three-times HH exposures) and group IV (four-times HH exposures). The triacylglycerol level, mRNA expression of HIF-1α and PPAR-γ were measured in rat liver from each group.Results: We demonstrated that triacylglycerol level, mRNA expression of HIF-1α and PPAR-γ is elevated in group I significantly compared to control group. In the intermittent HH groups (group II, III and IV), mRNA expression of HIF-1α and PPAR-γ tends to downregulate near to control group. However, the triacylglycerol level is still found increased in the intermittent HH exposures groups. Significant increasing of triacylglycerol level was found especially in group IV compared to control group.Conclusions: We conclude that intermittent HH exposures will increase the triacylglycerol level in rat liver, supported by the increasing of HIF-1α and PPAR-γ mRNA expression that act as transcription factor to promote triacylglycerol synthesis © 2021. Reports of Biochemistry & Molecular Biology. All Rights Reserved. |
HIF-1α; Hypoxia; Liver; PPAR-γ; Triacylglycerol |
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Varastegan Institute for Medical Sciences |
23223480 |
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Article |
Q3 |
467 |
10677 |
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688 |
Bachtiar B.M., Theodorea C.F., Tahapary D.L., Astrella C., Natalina, Bachtiar E.W. |
15831189400;57190048861;55944492500;57210793320;57193344580;6507328763; |
A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform |
2021 |
F1000Research |
10 |
|
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1 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117343626&doi=10.12688%2fF1000RESEARCH.28216.4&partnerID=40&md5=67091555cb3a43a5a6d2e958586434d2 |
Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia |
Bachtiar, B.M., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Theodorea, C.F., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Astrella, C., Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Natalina, Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Bachtiar, E.W., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia |
Background: Subgingival niche is one biofilm habitat containing rich microbiota, which plays an active role in maintaining the health of periodontal tissue and determining host response. As such, a study of changing subgingival biofilms is important for understanding the effect of a systemic condition. In this study, we compared the occurrence of six bacteria cohabiting in the subgingival area of periodontitis subjects, with (DP, n = 8) and without (NDP, n = 4) diabetes. Methods: The six genus and species of targeted bacteria were confirmed by 16S rRNA amplicon sequencing on MinION nanopore platform. Descriptive statistic was used to describe the obtained data. Results: We found that the six genus and species of targeted bacteria were detected but in different quantities in either group's periodontal pocket. Our data showed that Tannerella forsythia was the most abundant species in subgingival biofilms of the DP group of the red complex bacteria. In contrast, Aggregatibacter sp., which belongs to the phylum of proteobacteria, was present at a relatively lower level. In contrast, Fusobacterium sp., which belongs to orange complex bacteria, showed relative similarities in subgingival biofilms of both groups tested, while Veillonella sp., were abundant in the DP groups. Conclusions: Our data show that the diversity of classic periodontopathogens increased in the subgingival niche of periodontitis subjects with diabetes. It is the first study in Indonesia to apply MinION-based, full-length 16S rRNA amplicon sequencing in periodontitis patients with and without diabetes. © 2021. Bachtiar BM et al. |
16S rRNA; Diabetes; MinION; Periodontitis; Red Complex bacteria; Subgingival Microbiome |
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F1000 Research Ltd |
20461402 |
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Article |
Q1 |
1099 |
3793 |
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