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69 |
Tamara A., Coulson D.J., Latief J.S., Bakhashab S., Weaver J.U. |
57205305387;57219221240;57219224500;56418579000;57203055590; |
Upregulated anti-angiogenic miR-424-5p in type 1 diabetes (model of subclinical cardiovascular disease) correlates with endothelial progenitor cells, CXCR1/2 and other parameters of vascular health |
2021 |
Stem Cell Research and Therapy |
12 |
1 |
249 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105816910&doi=10.1186%2fs13287-021-02332-7&partnerID=40&md5=90e29bc673c4921f95cd1f09971c9525 |
Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 80218, Saudi Arabia; Department of Diabetes, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, NE9 6SH, United Kingdom; Vascular Biology and Medicine Theme, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom |
Tamara, A., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Coulson, D.J., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom; Latief, J.S., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Bakhashab, S., Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 80218, Saudi Arabia; Weaver, J.U., Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom, Department of Diabetes, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, NE9 6SH, United Kingdom, Vascular Biology and Medicine Theme, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom |
Background: In spite of clinical progress, cardiovascular disease (CVD) remains the predominant cause of mortality worldwide. Overexpression studies in animals have proven miR-424-5p to have anti-angiogenic properties. As type 1 diabetes mellitus (T1DM) without CVD displays endothelial dysfunction and reduced circulating endothelial progenitor cells (cEPCs), it offers a model of subclinical CVD. Therefore, we explored miR-424-5p, cytokines and vascular health in T1DM. Methods: Twenty-nine well-controlled T1DM patients with no CVD and 20-matched controls were studied. Cytokines IL8, TNF-α, IL7, VEGF-C, cEPCs/CD45dimCD34+CD133+ cells and ex-vivo proangiogenic cells (PACs)/fibronectin adhesion assay (FAA) were measured. MiR-424-5p in plasma and peripheral blood mononuclear cells (PBMC) along with mRNAs in PBMC was evaluated. Results: We found an elevation of IL7 (p = 0.008), IL8 (p = 0.003), TNF-α (p = 0.041), VEGF-C (p = 0.013), upregulation of mRNA CXCR1 (p = 0.009), CXCR2 (p < 0.001) and reduction of cEPCs (p < 0.001), PACs (p < 0.001) and FAA (p = 0.017) in T1DM. MiR-424-5p was upregulated in T1DM in PBMC (p < 0.001). MiR-424-5p was negatively correlated with cEPCs (p = 0.006), PACs (p = 0.005) and FAA (p < 0.001) and positively with HbA1c (p < 0.001), IL7 (p = 0.008), IL8 (p = 0.017), VEGF-C (p = 0.007), CXCR1 (p = 0.02) and CXCR2 (p = 0.001). ROC curve analyses showed (1) miR-424-5p to be a biomarker for T1DM (p < 0.001) and (2) significant upregulation of miR-424-5p, defining subclinical CVD, occurred at HbA1c of 46.5 mmol/mol (p = 0.002). Conclusion: We validated animal research on anti-angiogenic properties of miR-424-5p in T1DM. MiR-424-5p may be a biomarker for onset of subclinical CVD at HbA1c of 46.5 mmol/mol (pre-diabetes). Thus, miR-424-5p has potential use for CVD monitoring whilst anti-miR-424-5p-based therapies may be used to reduce CVD morbidity/mortality in T1DM. © 2021, The Author(s). |
CD45dimCD34+CD133+, CXCR1/2; IL8; MiR-424-5p; T1DM |
alanine aminotransferase; biological marker; CD133 antigen; CD34 antigen; CD40 antigen; chemokine receptor CXCR1; chemokine receptor CXCR2; complementary DNA; cyclin D1; cyclooxygenase 2; endothelial leukocyte adhesion molecule 1; fibroblast growth factor 2; gamma interferon inducible protein 10; glucose; hemoglobin A1c; interleukin 10; interleukin 16; interleukin 7; interleukin 8; messenger RNA; microRNA; microRNA 424 5p; PADGEM protein; platelet derived growth factor AA; receptor type tyrosine protein phosphatase C; somatomedin C; tissue inhibitor of metalloproteinase 1; triacylglycerol; tumor necrosis factor; unclassified drug; vasculotropin C; microRNA; MIRN424 microrna, human; adult; alanine aminotransferase blood level; Article; cardiovascular disease; cardiovascular risk; clinical a |
BioMed Central Ltd |
17576512 |
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33985567 |
Article |
Q1 |
1599 |
2021 |
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70 |
Hariyanto H., Yahya C.Q., Aritonang R.C.A. |
55906967200;57190857039;57219610092; |
Severe COVID-19 in the intensive care unit: a case series |
2021 |
Journal of Medical Case Reports |
15 |
1 |
259 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105198319&doi=10.1186%2fs13256-021-02799-1&partnerID=40&md5=e5b4ca83dd05aec07a1a292f27fde4db |
Faculty of Medicine, Department of Anesthesiology and Intensive Care, Universitas Pelita Harapan, Jl. M. H. Thamrin Boulevard 1100, Lippo Village Tangerang, Tangerang, Banten 15811, Indonesia; Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No 77, Jakarta Pusat, 10430, Indonesia; Siloam Hospitals Kelapa Dua, Jl. Kelapa Dua Raya No.1001, Kelapa Dua, Tangerang, Banten 15810, Indonesia |
Hariyanto, H., Faculty of Medicine, Department of Anesthesiology and Intensive Care, Universitas Pelita Harapan, Jl. M. H. Thamrin Boulevard 1100, Lippo Village Tangerang, Tangerang, Banten 15811, Indonesia, Siloam Hospitals Kelapa Dua, Jl. Kelapa Dua Raya No.1001, Kelapa Dua, Tangerang, Banten 15810, Indonesia; Yahya, C.Q., Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No 77, Jakarta Pusat, 10430, Indonesia; Aritonang, R.C.A., Faculty of Medicine, Department of Anesthesiology and Intensive Care, Universitas Pelita Harapan, Jl. M. H. Thamrin Boulevard 1100, Lippo Village Tangerang, Tangerang, Banten 15811, Indonesia, Siloam Hospitals Kelapa Dua, Jl. Kelapa Dua Raya No.1001, Kelapa Dua, Tangerang, Banten 15810, Indonesia |
Background: Coronavirus disease 2019 (COVID-19) was first identified in Indonesia in March 2020, and the number of infections has grown exponentially. The situation is at its worst, overwhelming intensive care unit (ICU) resources and capacity. Case presentation: This is a single-center observational case study of 21 confirmed COVID-19 patients admitted to the ICU from March 20, 2020, to April 31, 2020. Demographics, baseline comorbidities, clinical symptoms, laboratory tests, electrocardiogram (ECG) and chest imaging were obtained consecutively during patient care. We identified 21 patients with confirmed COVID-19 severe infection in our ICU. The mean (± standard deviation) age of the patients was 54 ± 10 years; 95% were men, with shortness of breath (90.6%) the most common symptom. Hypertension was identified as a comorbidity in 28.6% of patients. The most common reason for admission to the ICU was hypoxemic respiratory failure, with 80% (17 patients) requiring mechanical ventilation. Half of the patients (10) died between day 1 and day 18, with septic shock as the primary cause of death. Of the 11 surviving patients, five were discharged home, while six were discharged from the ICU but remained in the hospital ward. Even then, the median length of ICU stay amongst survivors was 18 days. Conclusions: To date, there are no known effective antiviral agents or specific therapy to treat COVID-19. As severe systemic inflammatory response and multiple organ failure seems to be the primary cause of death, supportive care in maintaining oxygenation and hemodynamic stability remain the mainstay goals in treating critically ill COVID-19 patients. © 2021, The Author(s). |
Case report; COVID-19; ICU; Mechanical ventilation; Respiratory failure; Septic shock; Severe infection |
alanine aminotransferase; antifungal agent; aspartate aminotransferase; azithromycin; C reactive protein; heparin; hydroxychloroquine; lactate dehydrogenase; meropenem; tocilizumab; adult; aged; alanine aminotransferase blood level; Article; artificial ventilation; aspartate aminotransferase blood level; case study; cause of death; clinical article; clinical feature; comorbidity; computer assisted tomography; coronavirus disease 2019; coughing; critically ill patient; disease duration; disease severity; dyspnea; electrocardiogram; erythrocyte sedimentation rate; fatigue; female; fever; ground glass opacity; hospital admission; hospital discharge; human; hypertension; hypoxemic respiratory failure; Indonesia; intensive care unit; intubation; laboratory test; lactate dehydrogenase blood leve |
BioMed Central Ltd |
17521947 |
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33941249 |
Article |
Q3 |
287 |
15275 |
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72 |
Fitriana I., Setiati S., Rizal E.W., Istanti R., Rinaldi I., Kojima T., Akishita M., Azwar M.K. |
55486095900;14325991900;57223021639;23496653300;23475122400;55240575700;7004867426;57202798959; |
Malnutrition and depression as predictors for 30-day unplanned readmission in older patient: a prospective cohort study to develop 7-point scoring system |
2021 |
BMC Geriatrics |
21 |
1 |
256 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104539861&doi=10.1186%2fs12877-021-02198-7&partnerID=40&md5=38aa06ca8c7777764cff2096359b93e7 |
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan |
Fitriana, I., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia, Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rizal, E.W., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Istanti, R., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Rinaldi, I., Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kojima, T., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Akishita, M., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Azwar, M.K., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Background: Readmission is related to high cost, high burden, and high risk for mortality in geriatric patients. A scoring system can be developed to predict the readmission of older inpatients to perform earlier interventions and prevent readmission. Methods: We followed prospectively inpatients aged 60 years and older for 30 days, with initial comprehensive geriatric assessment (CGA) on admission in a tertiary referral centre. Patients were assessed with CGA tools consisting of FRAIL scale (fatigue, resistance, ambulation, illness, loss of weight), the 15-item Geriatric Depression Scale, Mini Nutritional Assessment short-form (MNA-SF), the Barthel index for activities of daily living (ADL), Charlson Comorbidity Index (CCI), caregiver burden based on 4-item Zarit Burden Index (ZBI), and cognitive problem with Abbreviated Mental Test (AMT). Demographic data, malignancy diagnosis, and number of drugs were also recorded. We excluded data of deceased patients and patients transferred to other hospitals. We conducted stepwise multivariate regression analysis to develop the scoring system. Results: Thirty-day unplanned readmission rate was 37.6 %. Among 266 patients, 64.7 % of them were malnourished, and 46.5 % of them were readmitted. About 24 % were at risk for depression or having depressed mood, and 53.1 % of them were readmitted. In multivariate analysis, nutritional status (OR 2.152, 95 %CI 1.151–4.024), depression status (OR 1.884, 95 %CI 1.071–3.314), malignancy (OR 1.863 95 %CI 1.005–3.451), and functional status (OR 1.584, 95 %CI 0.885–2.835) were included in derivation of 7 score system. The scoring system had maximum score of 7 and incorporated malnutrition (2 points), depression (2 points), malignancy (2 points), and dependent functional status (1 point). A score of 3 or higher suggested 82 % probability of readmission within 30 days following discharge. Area under the curve (AUC) was 0.694 (p = 0.001). Conclusions: Malnutrition, depression, malignancy and functional problem are predictors for 30-day readmission. A practical CGA-based 7 scoring system had moderate accuracy and strong calibration in predicting 30-day unplanned readmission for older patients. © 2021, The Author(s). |
Comprehensive geriatric assessment; Depression; Malnutrition; Predictive score; Readmission |
aged; daily life activity; depression; geriatric assessment; hospital readmission; human; malnutrition; middle aged; nutritional assessment; nutritional status; prospective study; risk factor; Activities of Daily Living; Aged; Depression; Geriatric Assessment; Humans; Malnutrition; Middle Aged; Nutrition Assessment; Nutritional Status; Patient Readmission; Prospective Studies; Risk Factors |
BioMed Central Ltd |
14712318 |
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33865312 |
Article |
Q1 |
1414 |
2506 |
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73 |
Kosasih A., Koepfli C., Dahlan M.S., Hawley W.A., Baird J.K., Mueller I., Lobo N.F., Sutanto I. |
56584346800;26536294400;57195937625;7004280510;15921267800;7006910183;35392948100;6603791639; |
Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study |
2021 |
Malaria Journal |
20 |
1 |
177 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104141748&doi=10.1186%2fs12936-021-03709-y&partnerID=40&md5=9c099fec0d8bce6347bf112092d4561b |
PhD Programme in Biomedical Sciences, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; PT Epidemiologi Indonesia, Jakarta, Indonesia; UNICEF, Jakarta, Indonesia; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Department of Parasitology, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Kosasih, A., PhD Programme in Biomedical Sciences, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Koepfli, C., Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States, Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Dahlan, M.S., PT Epidemiologi Indonesia, Jakarta, Indonesia; Hawley, W.A., UNICEF, Jakarta, Indonesia; Baird, J.K., Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Mueller, I., Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Lobo, N.F., Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; Sutanto, I., Indonesian Medical Education and Research Institute, Jakarta, Indonesia, Department of Parasitology, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Background: A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas—an activity that is expected to reduce local transmission. Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia. Methods: RT-qPCR targeting pfs25 and pvs25 transcripts—gametocyte molecular markers for Plasmodium falciparum and Plasmodium vivax, respectively, was performed to detect and quantify gametocytes in blood samples of P. falciparum and P. vivax-infected subjects over the course of the MST study. The presence of both asexual and sexual parasites in microscopic and submicroscopic infections was compared from the start and end of the MST, using proportion tests as well as parametric and non-parametric tests. Results: Parasite prevalence remained unchanged for P. falciparum (6% = 52/811 versus 7% = 50/740, p = 0.838), and decreased slightly for P. vivax (24% = 192/811 versus 19% = 142/740, p = 0.035) between the MST baseline and endpoint. No significant difference was observed in gametocyte prevalence for either P. falciparum (2% = 19/803 versus 3% = 23/729, p = 0.353, OR = 1.34, 95%CI = 0.69–2.63), or P. vivax (7% = 49/744 versus 5% = 39/704, p = 0.442, OR = 0.83, 95%CI = 0.52–1.31). Even though there was an insignificant difference between the two time points, the majority of parasite positive subjects at the endpoint had been negative at baseline (P. falciparum: 66% = 29/44, P. vivax: 60% = 80/134). This was similarly demonstrated for the transmissible stage—where the majority of gametocyte positive subjects at the endpoint were negative at baseline (P. falciparum: 95% = 20/21, P. vivax: 94% = 30/32). These results were independent of treatment provided during MST activities. No difference was demonstrated in parasite and gametocyte density between both time points either in P. falciparum or P. vivax. Conclusion: In this study area, similar prevalence rates of P. falciparum and P. vivax parasites and gametocytes before and after MST, although in different individuals, points to a negligible impact on the parasite reservoir. Treatment administration based on parasite positivity as implemented in the MST should be reevaluated for the elimination strategy in the community. Trial registration Clinical trials registration NCT01878357. Registered 14 June 2013, https://www.clinicaltrials.gov/ct2/show/NCT01878357. © 2021, The Author(s). |
Gametocyte; Mass screening and treatment; Pfs25; Pvs25 |
dihydroartemisinin plus piperaquine; primaquine; adolescent; Article; blood sampling; cell density; controlled study; disease reservoir; endemic disease; female; gametocyte; gene; gene targeting; genetic transcription; human; Indonesia; longitudinal study; major clinical study; malaria falciparum; male; mass screening; microscopy; parasite clearance; parasite transmission; pfs25 gene; Plasmodium vivax malaria; population structure; prevalence; prospective study; pvs25 gene; randomized controlled trial; real time polymerase chain reaction; adult; aged; child; heterozygote; infant; isolation and purification; malaria falciparum; middle aged; parasitology; Plasmodium falciparum; Plasmodium vivax; Plasmodium vivax malaria; preschool child; very elderly; young adult; Adolescent; Adult; Aged; Ag |
BioMed Central Ltd |
14752875 |
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33836772 |
Article |
Q1 |
1718 |
1764 |
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74 |
Darmadi J., Batubara R.R., Himawan S., Azizah N.N., Audah H.K., Arsianti A., Kurniawaty E., Ismail I.S., Batubara I., Audah K.A. |
57222431230;57220745212;57222422725;57191927056;57222432027;36124567000;57214889313;7103005751;26031903000;15119028200; |
Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug |
2021 |
Scientific Reports |
11 |
1 |
6080 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102715983&doi=10.1038%2fs41598-021-85383-3&partnerID=40&md5=0ea6644166c67e4defd273cae7f6aa43 |
Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia; Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Darmadi, J., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Batubara, R.R., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Himawan, S., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Azizah, N.N., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Audah, H.K., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Arsianti, A., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia, Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Kurniawaty, E., Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Ismail, I.S., Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Batubara, I., Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia, Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Audah, K.A., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia, Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug. © 2021, The Author(s). |
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acetic acid; antineoplastic agent; plant extract; adipose tissue; animal; Artemia; chemistry; drug screening; HeLa cell line; HT-29 cell line; human; MCF-7 cell line; Meliaceae; metabolism; neoplasm; plant leaf; stem cell; Acetates; Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Artemia; Drug Screening Assays, Antitumor; HeLa Cells; HT29 Cells; Humans; MCF-7 Cells; Meliaceae; Neoplasms; Plant Extracts; Plant Leaves; Stem Cells |
Nature Research |
20452322 |
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33727582 |
Article |
Q1 |
1240 |
3130 |
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75 |
Lydia A., Setiati S., Soejono C.H., Istanti R., Marsigit J., Azwar M.K. |
8451287200;14325991900;24472241900;23496653300;57218912589;57202798959; |
Prevalence of prehypertension and its risk factors in midlife and late life: Indonesian family life survey 2014–2015 |
2021 |
BMC Public Health |
21 |
1 |
493 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102501346&doi=10.1186%2fs12889-021-10544-y&partnerID=40&md5=ca5ddee24de31f31b2409c6356d7d7e6 |
Department of Internal Medicine, Division of Nephrology and Hypertension, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Lydia, A., Department of Internal Medicine, Division of Nephrology and Hypertension, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Setiati, S., Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soejono, C.H., Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Istanti, R., Department of Internal Medicine, Division of Geriatric Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Marsigit, J., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Azwar, M.K., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Early detection of prehypertension is important to prevent hypertension-related complications, such as cardiovascular disease, cerebrovascular disease and all-cause mortality. Data regarding the prevalence of prehypertension among mid- and late-life population in Indonesia were lacking. It is crucial to obtain the prevalence data and identify the risk factors for prehypertension in Indonesia, which may differ from that of other countries. Methods: The cross-sectional analysis utilized multicenter data from Indonesian Family Life Survey-5 (IFLS-5) from 13 provinces in 2014–2015. We included all subjects at mid-and late-life (aged ≥40 years old) from IFLS-5 with complete blood pressure data and excluded those with prior diagnosis of hypertension. Prehypertension was defined as high-normal blood pressure according to International Society of Hypertension (ISH) 2020 guideline (systolic 130–139 mmHg and/or diastolic 85–89 mmHg). Sociodemographic factors, chronic medical conditions, physical activity, waist circumference and nutritional status were taken into account. Statistical analyses included bivariate and multivariate analyses. Results: There were 5874 subjects included. The prevalence of prehypertension among Indonesian adults aged > 40 years old was 32.5%. Age ≥ 60 years (adjusted OR 1.68, 95% CI 1.41–2.01, p < 0.001), male sex (adjusted OR 1.65, 95% CI 1.45–1.88, p < 0.001), overweight (adjusted OR 1.44, 95% CI 1.22–1.70, p < 0.001), obesity (adjusted OR 1.77, 95% CI 1.48–2.12, p < 0.001), and raised waist circumference (adjusted OR 1.32, 95% CI 1.11–1.56, p = 0.002) were the significant risk factors associated with prehypertension. Prehypertension was inversely associated with being underweight (adjusted OR 0.74, 95% CI 0.59–0.93, p = 0.009). Conclusions: The prevalence of prehypertension in Indonesian mid- and late-life populations is 32.5%. Age ≥ 60 years, male sex, overweight, obesity, and raised waist circumference are risk factors for prehypertension. © 2021, The Author(s). |
Indonesia; Mid- and late-life; Prehypertension; Risk factors |
adult; blood pressure; clinical trial; cross-sectional study; family size; human; hypertension; Indonesia; male; middle aged; multicenter study; prehypertension; prevalence; risk factor; Adult; Blood Pressure; Cross-Sectional Studies; Family Characteristics; Humans; Hypertension; Indonesia; Male; Middle Aged; Prehypertension; Prevalence; Risk Factors |
BioMed Central Ltd |
14712458 |
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33711980 |
Article |
Q1 |
1230 |
3166 |
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76 |
Lazarus G., Findyartini A., Putera A.M., Gamalliel N., Nugraha D., Adli I., Phowira J., Azzahra L., Ariffandi B., Widyahening I.S. |
57214599425;56543777300;57222064804;57222183873;57221389984;57222181089;57221489618;57222184743;57222178259;54893154400; |
Willingness to volunteer and readiness to practice of undergraduate medical students during the COVID-19 pandemic: a cross-sectional survey in Indonesia |
2021 |
BMC Medical Education |
21 |
1 |
138 |
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14 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101797052&doi=10.1186%2fs12909-021-02576-0&partnerID=40&md5=fe743e7efa2199d87c6345360ad4e627 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Salemba 6, Central, Jakarta, 10430, Indonesia; Medical Education Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Salemba 6, Central, Jakarta, 10430, Indonesia, Medical Education Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putera, A.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gamalliel, N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nugraha, D., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Adli, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Phowira, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azzahra, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariffandi, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widyahening, I.S., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The question to involve or restrict medical students’ involvement in the coronavirus disease 2019 (COVID-19) pandemic response remains contentious. As their state of preparation and perceptions in volunteering during this pandemic have yet to be investigated, this study aims to evaluate Indonesian medical students’ willingness to volunteer and readiness to practice during the COVID-19 pandemic. Methods: A web-based survey was conducted among undergraduate medical students throughout Indonesia. Socio-demographic and social interaction information, in addition to willingness to volunteer and readiness to practice, were obtained using a self-reported questionnaire. The significance level was set at 5%. Results: Among 4870 participants, 2374 (48.7%) expressed their willingness to volunteer, while only 906 (18.6%) had adequate readiness to practice. Male students, students with prior volunteering experience in health or non-health sectors, and students from public universities or living in Central Indonesia (vs Java) had higher scores of willingness and readiness to volunteer. Students from Sumatra also had better preparedness (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.15–2.12, p = 0.004), while the opposite occurred for students from Eastern Indonesia (OR 0.63, 95% CI: 0.44–0.89, p = 0.002)–when compared to students from Java. In addition, compared to students with high family income, students from lower-middle income families were less willing to volunteer (OR 0.76, 95% CI: 0.59–0.98, p = 0.034), though those with low family income had better readiness (OR 1.51, 95% CI: 1.10–2.08, p = 0.011). Shortage of medical personnel, sense of duty, and solicitation by stakeholders were the main reasons increasing the students’ willingness to volunteer; whereas contrarily fear for own’s health, absence of a cure, and fear of harming patients were the primary factors diminishing their willingness to volunteer. Conclusion: Our findings indicated that many Indonesian medical students are willing to volunteer, yet only few of them were ready to practice, indicating that further preparations are required to maximize their potentials and minimize their exposure to hazards. We suggest that their potentials as a firm support system during the pandemic should not be overlooked, and that the integration of relevant courses to the medical curricula are imperative to prepare for future public health emergencies. © 2021, The Author(s). |
COVID-19; Indonesia; Medical students; Readiness to practice; Willingness to volunteer |
clinical competence; curriculum; demography; epidemiology; fear; female; human; income; Indonesia; male; medical education; medical student; motivation; pandemic; psychology; self report; sex factor; volunteer; young adult; Clinical Competence; COVID-19; Curriculum; Education, Medical, Undergraduate; Fear; Female; Humans; Income; Indonesia; Male; Motivation; Pandemics; Residence Characteristics; SARS-CoV-2; Self Report; Sex Factors; Students, Medical; Volunteers; Young Adult |
BioMed Central Ltd |
14726920 |
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33648516 |
Article |
Q1 |
809 |
5954 |
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77 |
Findyartini A., Greviana N., Putera A.M., Sutanto R.L., Saki V.Y., Felaza E. |
56543777300;57197709749;57222064804;57222060277;57222061848;57217487889; |
The relationships between resilience and student personal factors in an undergraduate medical program |
2021 |
BMC Medical Education |
21 |
1 |
113 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101258190&doi=10.1186%2fs12909-021-02547-5&partnerID=40&md5=a9759408209ed0c6e18f2a706196b0ae |
Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Findyartini, A., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Putera, A.M., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sutanto, R.L., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saki, V.Y., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Felaza, E., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Resilience is an essential aspect of wellbeing that plays a major role in undergraduate medical education. Various personal and social factors are known to affect resilience. Empirical evidence remains limited regarding resilience and the personal factors that affect it among undergraduate medical students in an Asian setting. Therefore, this study aims to identify undergraduate medical students’ level of resilience and its relationships to personal factors in Indonesia. Methods: This cross-sectional study was conducted among undergraduate medical students in years 1–6. Respondents were asked to complete three validated questionnaires: the Connor-Davidson Resilience Scale (CD-RISC) to measure resilience, the Brief-COPE to assess coping mechanisms, and the Big Five Personality Test to measure five personality dimensions. Descriptive and Pearson’s correlation analyses were completed to explore relationships between each variable. Regression analysis was completed to analyze the extent to which coping mechanisms, personality, and academic achievement explained the variation in resilience scores. Results: A total of 1040 respondents completed the questionnaires (a 75.42% response rate). Students in both preclinical and clinical stages had quite good levels of resilience and higher scores on adaptive coping mechanisms than on maladaptive coping mechanisms. Adaptive and maladaptive coping mechanisms, Big Five Personality traits (extraversion, agreeableness, conscientiousness, neuroticism, and openness), and students’ academic achievement explained 46.9% of students’ resilience scores. Conclusions: Although the resilience scores in this study were comparable to resilience scores among undergraduate medical students in other settings, we found that coping mechanisms, personality traits, and academic performance may predict resilience among medical students. © 2021, The Author(s). |
Coping mechanism; Medical students; Personality traits; Resilience; Undergraduate |
cross-sectional study; human; Indonesia; medical education; medical student; personality; Cross-Sectional Studies; Education, Medical, Undergraduate; Humans; Indonesia; Personality; Students, Medical |
BioMed Central Ltd |
14726920 |
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33602176 |
Article |
Q1 |
809 |
5954 |
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80 |
Paramita R.I., Nelwan E.J., Fadilah F., Renesteen E., Puspandari N., Erlina L. |
54882436900;14527452900;56966708600;57216633036;56786591900;57190181680; |
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing |
2021 |
PLoS ONE |
15 |
12 December |
e0244358 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099074536&doi=10.1371%2fjournal.pone.0244358&partnerID=40&md5=4997d32055c7a3e5834f747ae4be685e |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, DKI Jakarta, Indonesia |
Paramita, R.I., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Renesteen, E., Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, DKI Jakarta, Indonesia; Erlina, L., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia |
Escherichia coli are one of the commonest bacteria causing bloodstream infection (BSI). The aim of the research was to identify the serotypes, MLST (Multi Locus Sequence Type), virulence genes, and antimicrobial resistance of E. coli isolated from bloodstream infection hospitalized patients in Cipto Mangunkusumo National Hospital Jakarta. We used whole genome sequencing methods rather than the conventional one, to characterized the serotypes, MLST (Multi Locus Sequence Type), virulence genes, and antimicrobial resistance (AMR) of E. coli. The composition of E. coli sequence types (ST) was as follows: ST131 (n=5), ST38 (n=3), ST405 (n=3), ST69 (n=3), and other STs (ST1057, ST127, ST167, ST3033, ST349, ST40, ST58, ST6630). Enteroaggregative E. coli (EAEC) and Extra-intestinal pathogenic E. coli (ExPEC) groups were found dominant in our samples. Twenty isolates carried virulence genes for host cells adherence and 15 for genes that encourage E. coli immune evasion by enhancing survival in serum. ESBL-genes were present in 17 E. coli isolates. Other AMR genes also encoded resistance against aminoglycosides, quinolones, chloramphenicol, macrolides and trimethoprim. The phylogeny analysis showed that phylogroup D is dominated and followed by phylogroup B2. The E. coli isolated from 22 patients in Cipto Mangunkusumo National Hospital Jakarta showed high diversity in serotypes, sequence types, virulence genes, and AMR genes. Based on this finding, routinely screening all bacterial isolates in health care facilities can improve clinical significance. By using Whole Genome Sequencing for laboratory-based surveillance can be a valuable early warning system for emerging pathogens and resistance mechanisms. © 2020 Paramita et al. |
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aminoglycoside antibiotic agent; beta lactam antibiotic; chloramphenicol; macrolide; quinoline derived antiinfective agent; trimethoprim; virulence factor; antibiotic resistance; Article; bacterial gene; bacterial genome; bacterial virulence; bacterium isolate; bloodstream infection; cell adhesion; clinical article; DNA isolation; enteroaggregative Escherichia coli; Escherichia coli; extraintestinal pathogenic Escherichia coli; gene isolation; gene sequence; genetic code; high throughput sequencing; hospital patient; host cell; human; Indonesia; multilocus sequence typing; nonhuman; nuclear magnetic resonance; phylogeny; serotype; virulence gene; whole genome sequencing; bacteremia; bacterial genome; classification; Escherichia coli; Escherichia coli infection; genetics; high throughput se |
Public Library of Science |
19326203 |
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33362261 |
Article |
Q1 |
990 |
4434 |
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82 |
Amanda G., Tafroji W., Sutoyo D.K., Burhan E., Haryanto B., Safari D. |
57193071364;57118271600;6506079672;36058554600;41861500300;23493586700; |
Serotype distribution and antimicrobial profile of Streptococcus pneumoniae isolated from adult patients with community-acquired pneumonia in Jakarta, Indonesia |
2021 |
Journal of Microbiology, Immunology and Infection |
54 |
6 |
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1175 |
1178 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094592942&doi=10.1016%2fj.jmii.2020.10.003&partnerID=40&md5=9c2a2f417f1387a35bf85921e1b795f4 |
Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Microbiology, Persahabatan Hospital, Jakarta, Indonesia |
Amanda, G., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sutoyo, D.K., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Burhan, E., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Haryanto, B., Department of Microbiology, Persahabatan Hospital, Jakarta, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Streptococcus pneumoniae is one of the primary causes of community-acquired pneumonia. The vaccine serotypes were dominant and could be isolated in 14% of adult patients, with serotype 3 being the most predominant (25%), followed by 6A, 6B, and 7F. Approximately, 44% of the isolates showed resistance to tetracycline. © 2020 |
Antibiotic resistance profile; Community-acquired pneumonia; Serotype; Streptococcus pneumoniae |
antiinfective agent; adolescent; adult; antibiotic resistance; community acquired infection; cross-sectional study; drug effect; female; genetics; human; Indonesia; isolation and purification; male; microbiology; middle aged; pneumonia; serotype; Streptococcus pneumoniae; young adult; Adolescent; Adult; Anti-Bacterial Agents; Community-Acquired Infections; Cross-Sectional Studies; Drug Resistance, Bacterial; Female; Humans; Indonesia; Male; Middle Aged; Pneumonia; Serogroup; Streptococcus pneumoniae; Young Adult |
Elsevier Ltd |
16841182 |
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33268305 |
Article |
Q1 |
1223 |
3210 |
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