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105 |
Akmal M.M., Pabittei D.R., Prapassaro T., Suhartono R., Moll F.L., van Herwaarden J.A. |
57212520722;36722034600;57205214358;57218884615;7103009095;6602663510; |
A systematic review of the current status of interventions for type II endoleak after EVAR for abdominal aortic aneurysms |
2021 |
International Journal of Surgery |
95 |
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106138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117194344&doi=10.1016%2fj.ijsu.2021.106138&partnerID=40&md5=04d622b377ba196029ff5e68c6be3e4c |
Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands; Vascular surgery Division, Departement of Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Indonesia; Departement of Physiology, Hasanudin University, Indonesia; Departement of vascular surgery, Siriraj Hospital, Mahidol UniversityBangkok, Thailand |
Akmal, M.M., Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands, Vascular surgery Division, Departement of Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Indonesia; Pabittei, D.R., Departement of Physiology, Hasanudin University, Indonesia; Prapassaro, T., Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands, Departement of vascular surgery, Siriraj Hospital, Mahidol UniversityBangkok, Thailand; Suhartono, R., Vascular surgery Division, Departement of Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Indonesia; Moll, F.L., Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands; van Herwaarden, J.A., Departement of vascular surgery, University Medical Center Utrecht, Utrecht, Netherlands |
Objective: To study the mid- and long-term outcomes of type II endoleak treatment after EVAR and the technical aspects of different techniques to exclude endoleaks which different embolic agents. Methods: A systematic review was performed using the approach recommended by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for meta-analyses of interventional studies. The comprehensive search was conducted using the following database: MEDLINE, EMBASE, and the Cochrane Library. Patient characteristic, intervention approaches, embolic agents, and results at mid and long term follow up were studied. Results: A total of 6 studies corresponding to a total of 141 patients fulfilled the inclusion criteria with a mean age of 73–78.6 years and a mean duration of follow up varying from 25 to 42 months. There were different techniques for embolization used (translumbar, transarterial, and transcaval approach) with various types of embolic agents. In all studies, the indication for embolization of the type II endoleaks was sac enlargement of more than 5 mm. A wide range of technical success rate was reported regardless of the intervention strategy being used (17,6%–100%). The overall technical success rate of all studies was 62%. Conclusion: This systematic review shows that there is a wide variety of techniques to exclude a persistent type II endoleak. Different kinds of embolic agents have be used. Due to a lack of peer reviewed data on longterm follow-up, it was not possible to come to recommendations what treatment would be the best for a durable exclusion of a persistent type II endoleak after an initially successful EVAR. There remains an urgent need for proper executed studies, either randomized or with close observation in relation to longer follow-up. © 2021 The Authors |
Abdominal aorta aneurysm; Aneurysm repair; Endoleaks; Endovascular aneurysm repair; Type |
ethylene vinyl alcohol copolymer; glue; iodinated poppyseed oil; onyx copolymer; thrombin; abdominal aortic aneurysm; aged; artificial embolization; clinical outcome; cohort analysis; conservative treatment; data extraction; endoleak; endovascular aneurysm repair; follow up; human; laparoscopic surgery; major clinical study; meta analysis; outcome assessment; postoperative infection; practice guideline; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; quality control; Review; selective transcaval embolization; surgical approach; systematic review; transarterial embolization; translumbar embolization; treatment duration; treatment indication; type ii endoleak; very elderly; adverse event; artificial embolization; endoleak; endovascular surgery; Aged; Aortic Aneurysm, Abdo |
Elsevier Ltd |
17439191 |
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34637951 |
Review |
Q1 |
1315 |
2831 |
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106 |
Tobing S.D.A.L., Hendriarto A., Wikanjaya R. |
57192893142;57216821517;57211909508; |
Conservative approach for treatment of Grisel's syndrome after resection of lympahadenitis tuberculosis of the neck: A rare case report |
2021 |
International Journal of Surgery Case Reports |
88 |
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106452 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116936259&doi=10.1016%2fj.ijscr.2021.106452&partnerID=40&md5=a61504c984a695791169d7a4a2464b5f |
Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tobing, S.D.A.L., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hendriarto, A., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wikanjaya, R., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Grisel's syndrome is a rare condition characterized by nontraumatic rotatory subluxation of the atlantoaxial joint, which was caused by previous inflammation around the head and neck. It is usually seen in children and signed as torticollis. There was no consensus for management, yet early diagnosis and treatment is paramount. Presentation of case: A 5-year-old girl came to outpatient clinic complaining of wry neck 1 day after surgical excision of her TB lymphadenitis and got worsen by time. There was no history of trauma around the neck. Examination under general anesthesia and CT scan revealed acquired severe torticollis consistent with Grisel's Syndrome Fielding type 3 accompanied by TB lymphadenitis, and TB myositis of the neck. Manipulation under general anesthesia and immobilization using Minerva cast followed by Lerman Cervicothoracal Osthosis was conducted. Discussion: This patient was diagnosed with Grisel's syndrome and underwent conservative treatment consisting of reduction under general anesthesia and immobilization using Minerva cast for 6 weeks. The patient was then applied Lherman Cervical Thoracic Orthosis (CTO) halo brace for another 3 months. Anti-tuberculous drug was given to control tuberculous infection. Eight months follow-up showed neither residual deformity, neck pain, nor movement limitation of the neck. Conclusion: Grisel's syndrome has excellent result that is treated with conservative treatment using reduction under general anesthesia and Minerva cast. © 2021 The Authors |
Acquired torticollis; Conservative; Grisel's syndrome; Minerva cast |
cobamamide; cyproheptadine; tuberculostatic agent; Article; atlantoaxial subluxation; body weight gain; case report; cervical lymph node; child; clinical article; computer assisted tomography; conservative treatment; disease exacerbation; excision; excisional biopsy; female; fever; follow up; general anesthesia; Grisel syndrome; headache; histopathology; hoarseness; human; human tissue; immobilization; infection control; interferon gamma release assay; Langhans giant cell; loss of appetite; lymphadenitis; myositis; nausea; neck malformation; neuroimaging; night sweat; nuclear magnetic resonance imaging; outpatient department; physical examination; preschool child; puncture; range of motion; sternocleidomastoid muscle; torticollis; tuberculin test; tuberculous lymphadenitis |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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107 |
Poerbonegoro N.L., Reksodiputro M.H., Sari D.P., Mufida T., Rahman M.A., Reksodiputro L.A., Audindra S., Yosia M. |
57222574894;35090488800;57292553600;57291865900;57291413400;57292781100;57222006228;57204933098; |
Cross-sectional study on the proportion of smell and taste disturbances in hospitalized COVID-19 patients |
2021 |
Annals of Medicine and Surgery |
71 |
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102909 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116899241&doi=10.1016%2fj.amsu.2021.102909&partnerID=40&md5=96e678393268c92055e16d284f8c40f7 |
Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Poerbonegoro, N.L., Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia; Reksodiputro, M.H., Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia; Sari, D.P., Otorhinolaryngology-Head Neck Surgery Medical Staff Group, Universitas Indonesia Hospital, Depok, West Java, Indonesia; Mufida, T., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rahman, M.A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, L.A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Audindra, S., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yosia, M., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: The number of confirmed Coronavirus Disease-2019 (COVID-19) cases in Indonesia had reached 1.4 million cases from a total population of 270 million. Smell and/or taste disturbances are frequently found as early symptoms of COVID-19 patients. Our study aimed to investigate the proportion and characteristics of anosmia and/or ageusia in COVID-19. Materials and methods: This cross-sectional study identifies the proportion and severity of smell and taste disturbances in COVID-19 patients. Subjects were recruited by consecutive sampling. All subjects were required to fill in the questionnaire modified from the American Academy of Otolaryngology-Head and Neck Surgery Anosmia Reporting Tool (AAO-HNS ART). Symptoms severity was measured with a numerical rating scale of 0–10; 0–3 is defined as mild, 4–6 as moderate, and 7–10 as severe. Results: Out of 51 subjects, 34 (66.7%) suffered from smell and/or taste disturbances. Twenty-nine of 34 subjects (85.3%) suffered from smell disturbance, and 24 of 34 subjects (70.5%) suffered from taste disturbance. Severe smell disturbance occurred in 68.9% of subjects, while severe taste disturbance occurred in 50%. The median onset was three days for smell disturbance and four days for taste disturbance after any symptoms of COVID-19. Conclusion: Smell and/or taste disturbances were early symptoms of COVID-19. These symptoms commonly occurred within the first four days of clinical onset and frequently manifested in severe conditions. © 2021 |
Ageusia; Anosmia; COVID-19; Indonesia |
adult; American Academy of Otolaryngology Head and Neck Surgery Anosmia Reporting Tool; Article; coronavirus disease 2019; cross-sectional study; disease assessment; disease severity; female; human; major clinical study; male; numeric rating scale; questionnaire; real time polymerase chain reaction; retrospective study; risk factor; smelling disorder; taste disorder; visual analog scale |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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108 |
Liberty I.A., Kodim N., Sartika R.A.D., Trihandini I., Tjekyan R.M.S., Zulkarnain, Pane M., Pratisthita L.B., Tahapary D.L., Soewondo P. |
57211435130;57210444174;41862490800;8449988100;57267287700;57267073300;55831164800;57221504201;55944492500;23475336100; |
Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011–2016) |
2021 |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
15 |
6 |
102280 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115349587&doi=10.1016%2fj.dsx.2021.102280&partnerID=40&md5=db55d7f5dcad157ad5a355acd19a0c89 |
Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Department of Public Nutrition, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Department of Biostatistics, Public Health Faculty Universitas Indonesia, Depok, Indonesia; National Institute Health Research and Development, Ministry of Health of the Republic of Indonesia, Indonesia; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Universitas Indonesia Hospital, Depok, Indonesia; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Liberty, I.A., Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia, Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Kodim, N., Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Sartika, R.A.D., Department of Public Nutrition, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Trihandini, I., Department of Biostatistics, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Tjekyan, R.M.S., Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Zulkarnain, Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Pane, M., National Institute Health Research and Development, Ministry of Health of the Republic of Indonesia, Indonesia; Pratisthita, L.B., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Universitas Indonesia Hospital, Depok, Indonesia; Tahapary, D.L., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background and aims: Reproductive-aged women are prone to type 2 diabetes mellitus. This study aims to evaluate the optimal cut off point of Triglyceride/Glucose Index for predicting glucose status conversion among women of reproductive age. Methods: This study involved normoglycemic and prediabetes women aged 20–49 years from the Bogor Non-Communicable Diseases Cohort Study (West Java, Indonesia) conducted from 2011 to 2016. Statistical analysis was performed using Receiver Operating Characteristics curve analysis with STATA version 15. Results: Among prediabetes subjects (n = 371), the cut-off point of TyG index for regression from prediabetes to normoglycemic subjects was <4.51 [sensitivity, specificity, AUC (95%CI) 83.9%, 80.1%, 0.913 (0.875–0.943), respectively] and the cut-off point for progression from prediabetes to diabetes was >4.54 [80.0%, 73.1%, 0.858 (0.807–0.900)]. Among normoglycemic subjects (n = 1300), the cut-off point of TyG index for progression to prediabetes and diabetes were >4.44 [80.1%, 71.1%, 0.834 (0.812–0.854)] and >4.47 [80.6%, 80.8%, 0.909 (0.890–0.926)] respectively. Conclusion: Based on sample of subjects evaluated between 2011 and 2016, TyG index appears to be a promising marker for glucose status conversion among reproductive-aged women in Jakarta, Indonesia. © 2021 |
Conversion; Glucose; Reproductive; TyG index; Women |
biological marker; cholesterol; glucose; hemoglobin A1c; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; adult; Article; cholesterol blood level; cohort analysis; controlled study; data analysis software; diabetes mellitus; evaluation study; female; follow up; glucose blood level; groups by age; human; impaired glucose tolerance; Indonesia; major clinical study; middle aged; oral glucose tolerance test; outcome assessment; predictive value; receiver operating characteristic; reference value; remission; reproduction; retrospective study; sensitivity and specificity; statistical analysis; triacylglycerol blood level; triglyceride glucose index; young adult |
Elsevier Ltd |
18714021 |
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34562866 |
Article |
Q2 |
684 |
7304 |
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111 |
Baskoro J.C., Hadi I.A.N., Ekaputri M., Winarsih N.S. |
57242005500;57242308100;57242005600;57211183552; |
Correlation between duration of untreated psychosis and working memory in early-onset psychotic disorders |
2021 |
Personalized Medicine in Psychiatry |
29-30 |
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100084 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114078676&doi=10.1016%2fj.pmip.2021.100084&partnerID=40&md5=56d11228ab6c85aba3075e3f4f99e800 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia |
Baskoro, J.C., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia; Hadi, I.A.N., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia; Ekaputri, M., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia; Winarsih, N.S., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta Pusat, DKI, Jakarta, 10430, Indonesia |
Psychotic disorders are morbid mental disorders that impair working memory. Theory suggests that longer duration of untreated psychosis (DUP) results in worse working memory. However, results from previous studies are contradictory, with no study having been conducted in children. This study aims at finding out the association between duration of untreated psychosis and working memory in children. This is a cross-sectional study with 45 subjects. DUP was collected from medical records whereas working memory was measured using digit span backward raw score. Average digit span backward scores of subjects was 3.7 ± 1.18. Analysis using Spearman test showed no significant association (p = 0.128) between DUP and working memory. In conclusion, there is no association between DUP and working memory in children, therefore we recommend that psychiatrists pay attention to working memory impairment in all pediatric patients with psychotic disorders, regardless of their DUP. © 2021 Elsevier Inc. |
Children; Duration of untreated psychosis; Psychosis; Working memory |
neuroleptic agent; acute psychosis; adolescent; adult; Article; attention; child; child psychiatry; clinical article; clinical assessment; clinical feature; controlled study; correlation analysis; cross-sectional study; digit span backward raw score; disease association; disease duration; duration of untreated psychosis; female; human; male; medical record; medication compliance; memory test; outcome assessment; patient compliance; pediatric patient; psychosis; schizophrenia; treatment duration; working memory |
Elsevier Inc. |
24681717 |
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Article |
#N/A |
#N/A |
#N/A |
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113 |
Tirtayasa P.M.W., Samuel A.G., Lisnawati, Retnowulan A. |
56245176500;57226642220;24449072000;57226640316; |
Parameatal glans cyst: A case report |
2021 |
Urology Case Reports |
39 |
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101802 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112167978&doi=10.1016%2fj.eucr.2021.101802&partnerID=40&md5=a508fda307bc2bbe4ba2dcbc8048eb84 |
Department of Urology, Faculty of Medicine Universitas Udayana, Bali, Indonesia; Urology Consultant, Pelni General Hospital, Jakarta, Indonesia; Pathology Consultant, Pelni General Hospital, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Tirtayasa, P.M.W., Department of Urology, Faculty of Medicine Universitas Udayana, Bali, Indonesia; Samuel, A.G., Urology Consultant, Pelni General Hospital, Jakarta, Indonesia; Lisnawati, Pathology Consultant, Pelni General Hospital, Jakarta, Indonesia, Department of Pathological Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Retnowulan, A., Pathology Consultant, Pelni General Hospital, Jakarta, Indonesia, Department of Pathological Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Parameatal glans cyst is unusual and only a few cases reported until currently. We presented a four-year-old boy with dysuria and inappropriate appearance of parameatal glans cyst. The cystic mass was slow-growing and was present since birth. Complete surgical excision was performed to prevent recurrencies and to achieve good cosmesis. © 2021 The Authors |
Glans cyst; Parameatal cyst; Urethral cyst |
Article; case report; child; clinical article; cuboidal epithelium; cyst; dysuria; epithelium; esthetic surgery; excision; follow up; general anesthesia; globular cystic swelling; histopathology; human; human tissue; male; parameatal glans cyst; penis glans; physical examination; preschool child; squamous epithelium; swelling; urethra; urethral meatus; urinalysis |
Elsevier Inc. |
22144420 |
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Article |
Q3 |
245 |
16962 |
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114 |
Andrianto, Al-Farabi M.J., Nugraha R.A., Marsudi B.A., Azmi Y. |
57221812919;57210466548;57200701510;57201975146;57200278939; |
Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis |
2021 |
Microvascular Research |
138 |
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104224 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111341102&doi=10.1016%2fj.mvr.2021.104224&partnerID=40&md5=d5cc3fe2a0d5a70658ecff8ad7fa6f8b |
Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia |
Andrianto, Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Al-Farabi, M.J., Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Nugraha, R.A., Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Marsudi, B.A., Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azmi, Y., Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia |
Background: Several studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial dysfunction is often found in severe cases of coronavirus disease 2019 (COVID-19). To better understand the prognostic values of endothelial dysfunction in COVID-19-associated coagulopathy, we conducted a systematic review and meta-analysis to assess biomarkers of endothelial cells in patients with COVID-19. Methods: A literature search was conducted on online databases for observational studies evaluating biomarkers of endothelial dysfunction and composite poor outcomes in COVID-19 patients. Results: A total of 1187 patients from 17 studies were included in this analysis. The estimated pooled means for von Willebrand Factor (VWF) antigen levels in COVID-19 patients was higher compared to healthy control (306.42 [95% confidence interval (CI) 291.37–321.48], p < 0.001; I2:86%), with the highest VWF antigen levels was found in deceased COVID-19 patients (448.57 [95% CI 407.20–489.93], p < 0.001; I2:0%). Meta-analysis showed that higher plasma levels of VWF antigen, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 antigen (PAI-1) antigen, and soluble thrombomodulin (sTM) were associated with composite poor outcome in COVID-19 patients ([standardized mean difference (SMD) 0.74 [0.33–1.16], p < 0.001; I2:80.4%], [SMD 0.55 [0.19–0.92], p = 0.003; I2:6.4%], [SMD 0.33 [0.04–0.62], p = 0.025; I2:7.9%], and [SMD 0.55 [0.10–0.99], p = 0.015; I2:23.6%], respectively). Conclusion: The estimated pooled means show increased levels of VWF antigen in COVID-19 patients. Several biomarkers of endothelial dysfunction, including VFW antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19. PROSPERO registration number: CRD42021228821 © 2021 Elsevier Inc. |
COVID-19; Endothelial dysfunction; Plasminogen activator inhibitor-1; Thrombomodulin; Tissue-type plasminogen activator; von Willebrand Factor |
biological marker; plasminogen activator inhibitor 1; thrombomodulin; tissue plasminogen activator; von Willebrand factor; biological marker; plasminogen activator inhibitor 1; SERPINE1 protein, human; THBD protein, human; thrombomodulin; tissue plasminogen activator; von Willebrand factor; adult; aged; Article; clinical outcome; controlled study; coronavirus disease 2019; endothelial dysfunction; female; human; major clinical study; male; publication bias; systematic review; blood; diagnosis; meta analysis; metabolism; middle aged; pathophysiology; predictive value; prognosis; therapy; vascular endothelium; very elderly; Adult; Aged; Aged, 80 and over; Biomarkers; COVID-19; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Predictive Value of Tes |
Academic Press Inc. |
00262862 |
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34273359 |
Article |
Q2 |
819 |
5848 |
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115 |
Meutia A.P., Yonathan K., Widia F. |
57203368133;57226144513;26028200800; |
Giant urethral caruncle resembling urethral prolapse causing outflow obstruction |
2021 |
Urology Case Reports |
39 |
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101783 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110776549&doi=10.1016%2fj.eucr.2021.101783&partnerID=40&md5=01ebfd6f9c1caac70e9244d1c3ffe391 |
Division of Urogynecology and Reconstruction Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Urogynecology Clinic, Bunda General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Meutia, A.P., Division of Urogynecology and Reconstruction Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Urogynecology Clinic, Bunda General Hospital, Jakarta, Indonesia; Yonathan, K., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Widia, F., Department of Urology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Urethral caruncle is a rare condition primarily affecting elderly. Sometimes, it resembles urethral prolapse or malignancies. It can even cause outflow obstruction or urinary retention. A case of 83-years-old woman with urinary retention since a week prior was presented. Physical examination revealed a bulging mass originating from posterior lip of external urethral meatus. Due to the size, it caused outflow obstruction. The whole mass was excised. Histology examination reported the mass as urethral caruncle. Urethral caruncle is a common problem in elderly which rarely cause outflow obstruction. A thorough examination is required to distinguish it from malignancies and other disorders. © 2021 |
Pelvic organ prolapse; Urethral caruncle; Urethral disease |
aged; Article; blood cell count; case report; clinical article; female; general anesthesia; histology; histopathology; human; human tissue; pelvic examination; physical examination; postmenopause; urethra disease; urethra obstruction; urethral caruncle; urethral prolapse; urine retention; uroflowmetry; urothelium; vital sign |
Elsevier Inc. |
22144420 |
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Article |
Q3 |
245 |
16962 |
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117 |
Umiatin, Indrasari W., Taryudi, Sari P., Mazfufah N.F., Rosadi I. |
57202292099;56069603500;57003576500;55776482300;57215595521;57204720098; |
Effect of pulse electromagnetic field exposure on the expression of lipo protein lipase (LPL) on the differentiation of mesenchymal stem cell |
2021 |
Journal of Physics: Conference Series |
2019 |
1 |
012107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119203085&doi=10.1088%2f1742-6596%2f2019%2f1%2f012107&partnerID=40&md5=cd764de9d9b9c1287f97fb09cfd8eea2 |
Department of Physics, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Indonesia; Department of Electronic Engineering, Faculty of Engineering, Universitas Negeri Jakarta, Indonesia; Department of Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Jl. Rawamangun Muka, Jakarta, 13220, Indonesia; Stem Cells and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, Indonesia |
Umiatin, Department of Physics, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Indonesia; Indrasari, W., Department of Physics, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Indonesia; Taryudi, Department of Electronic Engineering, Faculty of Engineering, Universitas Negeri Jakarta, Indonesia; Sari, P., Department of Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Jl. Rawamangun Muka, Jakarta, 13220, Indonesia; Mazfufah, N.F., Stem Cells and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Indonesia; Rosadi, I., Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, Indonesia |
Pulsed electromagnetic fields (PEMFs) have an important role in cell differentiation. Previous study reported that PEMFs had positive and negative effect towards cell differentiation that depends on their frequencies applied to the cells. Human adipose-derived stem cells (ASCs) are mesenchymal stem cells that have an ability to differentiate into several types of cell including adipocytes, chondrocytes and osteocytes. This study aimed to evaluate the effect of human ASCs towards their adipogenic differentiation during PEMFs exposure. Human ASCs were isolated from adipose tissue. The cells then cultured in specific medium of adipocyte that induced ASCs differentiation along with PEMFs exposure. The maximum magnetic field used is 2 mT with a frequency of 75 Hz. To confirm the effect of PEMFs exposure towards adipogenic differentiation, mRNA expression of lipo protein lipase (LPL) was measured in mRNA expression level. The results showed that ASCs cultured on adipogenic differentiation without PEMFs exposure gradually increased LPL expression until day 14 of observation, while ASCs with PEMFs exposure significantly decreased LPL expression from day 2 to day 14. Based on the results, we concluded that PEMFs exposure can inhibit LPL expression that suppressed adipogenic differentiation. © 2021 Institute of Physics Publishing. All rights reserved. |
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Electromagnetic field effects; Electromagnetic fields; Proteins; Stem cells; Adipogenic differentiations; Adipose derived stem cells; Cell differentiation; Cell-be; Cell/B.E; Electromagnetic field exposure; Human adipose; Lipo proteins; Mesenchymal stem cell; Pulsed electromagnetic fields; Cell culture |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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118 |
Sen L.T., Siste K., Hanafi E., Murtani B.J., Christian H., Limawan A.P., Adrian, Siswidiani L.P. |
57219034101;55644113100;56737010600;57216652176;57209266195;57202712511;57216932703;57219029296; |
Insights Into Adolescents' Substance Use in a Low–Middle-Income Country During the COVID-19 Pandemic |
2021 |
Frontiers in Psychiatry |
12 |
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739698 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118257704&doi=10.3389%2ffpsyt.2021.739698&partnerID=40&md5=9b8aba71c0b6aaab6c7e81012e3c8927 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: The COVID-19 pandemic and its lockdown have been a significant life event for many individuals, particularly adolescents. The immense psychological pressure could drive risky behavior, e.g., substance use, while lockdown might lead to decreased use. This study aimed to observe the change in substance use among adolescents in Indonesia and the moderating variables to consumption during the COVID-19 lockdown period. Methods: This study utilized an online survey from April 28, 2020 to June 30, 2020. The hyperlink was disseminated to school administrators and parenting groups through social media and direct messages. A total of 2,932 adolescents (17.4 ± 2.24 and 78.7% females) submitted valid responses. The survey was comprised of a sociodemographic section, substance use details, and psychometric sections, including the Alcohol Use Disorders Identification Test (AUDIT), Cigarette Dependence Scale 12 (CDS-12), Pittsburgh Sleep Quality Index (PSQI), and Strength and Difficulties Questionnaire (SDQ). Results: Overall, adolescent alcohol use during the pandemic was 5.1%, cigarette smoking was 3.1%, and drug consumption was 0.4%. Over half (53.4%) of alcohol drinkers reported increased drinking, and 33.1% had harmful or dependence-like drinking behavior; in contrast, 44.4% of adolescent smokers disclosed reduced cigarette consumption. Around 37.8% of the drug users indicated increased use. During the pandemic, adolescent alcohol use was associated with higher education [adjusted odds ratio (AOR) = 2.67, 95% confidence interval (CI) 1.02–4.86, p = 0.04], higher AUDIT scores (AOR = 1.33, 95% CI 1.25–1.42, p < 0.001), and very low prosocial behavior (AOR = 2.46, 95% CI 1.52–3.88, p < 0.001). Cigarette smoking was correlated with male sex (AOR = 9.56, 95% CI 5.64–16.62, p < 0.001), age (AOR = 1.40, 95% CI 1.14–1.75, p < 0.001), and higher CDS score (AOR = 1.17, 95% CI 1.13–1.20, p < 0.001). Conclusions: Rates of adolescent substance use were significant, with sizeable proportions reporting higher usage. This appeared to occur predominantly in specific demographics and those with a lower protective psychosocial attribute, i.e., prosocial behavior, during the lockdown. These findings should urge the strengthening of adolescent addiction care during and after the pandemic. © Copyright © 2021 Sen, Siste, Hanafi, Murtani, Christian, Limawan, Adrian and Siswidiani. |
adolescent; alcohol; cigarette; COVID-19; drugs; Indonesia |
adolescent; Alcohol Use Disorders Identification Test; Article; Cigarette Dependence Scale 12; cigarette smoking; controlled study; coronavirus disease 2019; demography; descriptive research; educational status; female; health care survey; human; Indonesia; low income country; major clinical study; male; mental disease assessment; middle income country; online analysis; pandemic; Pittsburgh Sleep Quality Index; prevalence; prosocial behavior; psychometry; sex difference; social media; social status; Strength and Difficulties Questionnaire; substance use |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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