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Triwidodo A., Rahyussalim A.J., Yulisa N.D., Pandelaki J., Huraiby L.S., Hadi I.A.N., Liosha F.Y., Dilogo I.H. |
57222626174;55212166100;57191033188;35759266900;57410470800;57345259600;57195941059;56161962800; |
Sacrum morphometry and spinopelvic parameters among the Indonesian population using computed tomography scans |
2021 |
Medicine (United States) |
100 |
47 |
e27955 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122758150&doi=10.1097%2fMD.0000000000027955&partnerID=40&md5=fcef27e030576bfa693c1f9a81c6abd9 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Triwidodo, A., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yulisa, N.D., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Huraiby, L.S., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hadi, I.A.N., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Liosha, F.Y., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
This is a cross-sectional study. This study aims to describe the characteristics of sacrum vertebrae and spinopelvic parameters among the Indonesian population and compare them with studies from other populations. This study also intends to determine the sexual dimorphism of sacrum vertebrae and find the correlations between spinopelvic parameters. Morphometry of the sacrum is necessary for designing sacral prosthesis and instrumentations. Knowledge of spinopelvic parameters further supports the prosthesis installation procedure to restore the physiological spinal alignment of the patients. However, previous studies showed varied results among different populations. This is the first study to be conducted among the Indonesian population. Morphometric dimensions of sacrum vertebrae and the spinopelvic parameters (pelvic incidence, pelvic tilt, sacral slope, lumbar lordosis) were analyzed using thin-cut (1 mm) computed tomography images in 150 males and 150 females, aged 25 to 50 years without any spinal pathology. Generally, the size of the sacrum vertebrae was greater in males (P < .05). The sacral index, curvature index, and corporo-basal index were statistically different between genders (P < .001). Lumbar lordosis was the only spinopelvic parameter found significantly greater in females (P < .001). Significant positive correlations between all spinopelvic parameters, except for lumbar lordosis and pelvic tilt, were found in the present study (P < .001). The study serves as the first large series database of sacrum morphometric characteristics and spinopelvic parameters of the Indonesian population. There was significant gender-associated differences in various dimensions of sacrum vertebrae. The sacral index was found to be the most useful parameter for sex determination. There were strong significant positive correlations between various spinopelvic parameters. A comparison of populations revealed morphometric characteristic differences, which is proved to be critical in surgical implications. Copyright © 2021 the Author(s). |
Computed tomography scans; Indonesian population; Morphometry; Sacrum vertebrae; Spinopelvic parameters |
adult; cross-sectional study; diagnostic imaging; female; human; Indonesia; lumbar vertebra; male; middle aged; pelvis; sacrum; sexual characteristics; x-ray computed tomography; Adult; Cross-Sectional Studies; Female; Humans; Indonesia; Lumbar Vertebrae; Male; Middle Aged; Pelvis; Sacrum; Sex Characteristics; Tomography, X-Ray Computed |
Lippincott Williams and Wilkins |
00257974 |
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34964781 |
Article |
Q2 |
590 |
8573 |
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84 |
Makmun D., Simadibrata M., Abdullah M., Syam A.F., Shatri H., Fauzi A., Renaldi K., Maulahela H., Utari A.P., Pribadi R.R., Muzellina V.N., Nursyirwan S.A. |
16638046900;23499598400;7103393434;8443384400;28767986500;36518523000;57190963547;57189612709;57113585900;57194732282;57223968527;57249143800; |
Retrospective Study Colorectal cancer patients in a tertiary hospital in Indonesia: Prevalence of the younger population and associated factors |
2021 |
World Journal of Clinical Cases |
9 |
32 |
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9804 |
9814 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119652838&doi=10.12998%2fwjcc.v9.i32.9804&partnerID=40&md5=75cf4743775cd03169188a4206cb7cb0 |
Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia |
Makmun, D., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Simadibrata, M., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Abdullah, M., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Syam, A.F., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Shatri, H., Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Fauzi, A., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Renaldi, K., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Maulahela, H., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Utari, A.P., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Pribadi, R.R., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Muzellina, V.N., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia |
BACKGROUND An increasing trend in colorectal cancer (CRC) occurring at younger ages has been observed worldwide, even though incidence is declining in the general population. Most currently available guidelines still recommend CRC screening for older populations, despite an alarming rise in early-onset CRC incidence. Risk stratification is necessary to further determine the population most at risk for early-onset CRC. However, epidemiological data on related clinical characteristics and potential risk factors, especially in developing countries, have not been widely reported. AIM To investigate the prevalence, demographics, clinicopathologic features, and associated factors of young-onset CRC patients in a tertiary hospital in Indonesia. METHODS Patients undergoing colonoscopy examination between 2008 and 2019, yielding a diagnosis of CRC were identified from medical records. The subjects were classified into two groups according to their age at diagnosis, namely early-onset (18–49 years old) and late-onset (≥ 50-years-old). Demographic data, characteristics, and risk factors of both onset age groups were evaluated using the chisquare and Fisher’s exact test. RESULTS Among 495 CRC patients confirmed by histopathology, 205 (41.4%) were classified as early-onset and 290 (58.6%) as late-onset. Most subjects in the early-onset CRC group were male (53.7%), with 89.8% displaying adenocarcinoma histopathology. A majority (78%) of the early-onset CRC patients had left-sided tumors, with the rectum (41%) and rectosigmoid (17.6%) being the most common sites. Abdominal pain was the most frequent symptom in the early-onset CRC patients (55.6%), which was significantly higher than that in the late-onset CRC patients (43.8%, P > 0.05). Early-onset CRC cases were more likely to be underweight (34.6% vs 20.0%, P < 0.001) compared to late-onset CRC cases. The proportion of subjects with suspected hereditary nonpolyposis colorectal cancer (HNPCC) was also higher in the early-onset CRC group than in the late-onset age group (9.3% vs 4.1%, P < 0.05). However, no difference was observed in the parental or family histories of CRC cases. CONCLUSION Early-onset CRC patients were more likely to have abdominal pain, underweight status, and HNPCC suspicion than late-onset CRC patients. © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
Associated factors; Colorectal cancer; Early onset; Epidemiology; Indonesia; Tertiary hospital |
abdominal pain; adenocarcinoma; adult; aged; Article; body mass; carcinoid; colon; colonoscopy; colorectal cancer; cross-sectional study; diabetes mellitus; familial adenomatous polyposis; female; hereditary nonpolyposis colorectal cancer; histopathology; human; human tissue; hypertension; major clinical study; male; medical record; obesity; prevalence; rectum; rectum hemorrhage; retrospective study; risk factor; smoking; underweight; very elderly |
Baishideng Publishing Group Co |
23078960 |
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Article |
Q3 |
368 |
12908 |
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85 |
Wiguna T., Minayati K., Kaligis F., Ismail R.I., Wijaya E., Murtani B.J., Pradana K. |
24367785700;57218681686;36604651700;55996895500;57358945000;57216652176;57220165625; |
The Effect of Cyberbullying, Abuse, and Screen Time on Non-suicidal Self-Injury Among Adolescents During the Pandemic: A Perspective From the Mediating Role of Stress |
2021 |
Frontiers in Psychiatry |
12 |
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743329 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120410832&doi=10.3389%2ffpsyt.2021.743329&partnerID=40&md5=721d9aa51662421c0092a11d6eaf48a8 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Psychology, Universitas Tarumanegara, Jakarta, Indonesia |
Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wijaya, E., Faculty of Psychology, Universitas Tarumanegara, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pradana, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Adolescence is often a period of turmoil. The COVID-19 pandemic has increased adolescents' difficulty due to mental health consequences that may affect their developmental milestones. This study constructed and empirically tested a theoretical model of three predictive factors (cyberbullying, abuse, and screen time) and stress as the mediating factor in adolescent non-suicidal self-injury (NSSI). Structural equation model (SEM) analysis was applied to investigate stress as a mediating factor in the relationship between adolescent NSSI and cyberbullying, abuse, and screen time. This cross-sectional study used a “crowdsourcing” sample collection method to recruit 464 adolescents aged 11–17 years who were administered a questionnaire comprising scales on cyberbullying, abuse, screen time, stress, and NSSI. All scales had construct reliabilities ranging from 0.759 to 0.958. SEM statistical analysis was performed using Lisrel version 8.8 (Scientific Software International, USA) for Windows (Microsoft Corporation, Redmond, WA, USA). The mean (± SD) age of the cohort was 14.61 ± 1.65 years, and consisted of 66.7% females. Secondary high school was the highest educational background (58%). The study found that cyberbullying and abuse were direct positive predictors (critical t-value for the path > 1.96; p < 0.05) of adolescent NSSI; however, screen time did not have any direct relationship. Furthermore, stress was a significant full mediating factor of screen time and a partial mediating factor of cyberbullying and abuse in the relationship with adolescent NSSI (critical t-value of the path = 5.27; p < 0.05). Cyberbullying, screen time, and abuse with the mediating effect of stress could explain 48% of the variance in adolescent NSSI (R2 = 0.48). Adolescent mental health prevention and promotion programs need to be redesigned during the current COVID-19 pandemic to manage their stress and minimize the mental health consequences of cyberbullying, abuse, and inappropriately increased screen time. Copyright © 2021 Wiguna, Minayati, Kaligis, Ismail, Wijaya, Murtani and Pradana. |
abuse; adolescents; COVID-19; cyberbullying; Indonesia; non-suicidal self-injury; screen time; stress |
abuse; adolescent; Article; automutilation; coronavirus disease 2019; cross-sectional study; cyberbullying; educational status; female; health program; human; male; mental health; pandemic; physiological stress; prediction; questionnaire; screen time |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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86 |
Gde Putra Semara Jaya A.A., Tantri A.R., Heriwardito A., Mansjoer A. |
57352086800;57188933853;57195378515;24335647800; |
Single-centre, double-blind, randomised, parallel-group, superiority study to evaluate the effectiveness of general anaesthesia and ultrasound-guided transversus thoracis muscle plane block combination in adult cardiac surgery for reducing the surgical stress response: Clinical trial protocol |
2021 |
BMJ Open |
11 |
11 |
e051008 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119887424&doi=10.1136%2fbmjopen-2021-051008&partnerID=40&md5=0586982ad2f206c40847d8ac96911ca0 |
Department of Anesthesiology and Intensive Care, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Indonesia |
Gde Putra Semara Jaya, A.A., Department of Anesthesiology and Intensive Care, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Tantri, A.R., Department of Anesthesiology and Intensive Care, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Heriwardito, A., Department of Anesthesiology and Intensive Care, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Mansjoer, A., Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Indonesia |
Introduction Adult open-heart surgery is a major surgery that causes surgical stress response and activation of the immune system, contributing further to postoperative complications. Transversus thoracis muscle plane block (TTPB) may potentially benefit in reducing the surgical stress response. This study aims to know the effectiveness of preoperative TTPB in adult open-heart surgery for reducing the surgical stress response. Methods and analysis This study is a prospective, double-blind, randomised control trial comparing the combination of general anaesthesia and TTPB versus general anaesthesia only in adult open-heart surgery. Forty-two eligible subjects will be randomly assigned to the TTPB group or control group. The primary outcomes are the difference between the two groups in the means of postoperative cortisol and interleukin-6 plasma levels at 24 hours and 48 hours after cardiac intensive care unit admission. The secondary outcomes are the difference between the two groups in the means of total 24-hour postoperative morphine consumption and time of first postoperative patient-controlled analgesia (PCA) dose. Ethics and dissemination The study protocol and informed consent forms have been reviewed and approved by the Ethics Committee of Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital. The result will be released to the medical community through presentation and publication in peer-reviewed journals. Trial registration number NCT04544254. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
adult anaesthesia; anaesthesia in cardiology; cardiothoracic surgery; pain management |
bupivacaine; fentanyl; hydrocortisone; interleukin 6; midazolam; morphine; paracetamol; rocuronium; sevoflurane; narcotic analgesic agent; adult; aged; Article; clinical article; comparative effectiveness; controlled study; coronary care unit; endotracheal intubation; enzyme linked immunosorbent assay; female; general anesthesia; heart surgery; hospital admission; human; male; nerve block; open heart surgery; oxygen therapy; patient controlled analgesia; postoperative period; protein blood level; randomized controlled trial (topic); surgical stress; transversus thoracis muscle plane block; double blind procedure; general anesthesia; interventional ultrasonography; muscle; postoperative pain; prospective study; Adult; Analgesics, Opioid; Anesthesia, General; Cardiac Surgical Procedures; Dou |
BMJ Publishing Group |
20446055 |
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34764171 |
Article |
Q1 |
1132 |
3624 |
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87 |
Miranda E., Bramono K., Rizky L.A., Hayun |
57208259598;9843236700;57193502812;37053937800; |
Preparation and stability evaluation of ll-37 cream |
2021 |
International Journal of Applied Pharmaceutics |
13 |
6 |
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139 |
143 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121048883&doi=10.22159%2fIJAP.2021V13I6.39639&partnerID=40&md5=1b6a1a02cc0417196461dd2568afa7d5 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rizky, L.A., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hayun, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Objective: The present study aimed to prepare LL-37 in a cream formulation (O/W emulsion) and evaluate its stability by determining the physical changes in the cream and concentration of LL-37 using validated high-performance liquid chromatography. Methods: The method was conducted at room temperature using a C18 column (5 µm × 250 mm × 4.6 mm) as a stationary phase, a mixture of 0.1% trifluoroacetic acid (TFA)/water (A) and 0.1% TFA/acetonitrile (B) (85:15) as the mobile phase, a flow rate of 1.0mL/min, an d photodiode array set at 228 nm as the detector. The method was validated in compliance with the Association of Official Analytical Chemists and International Conference on Harmonization guidelines. It demonstrated excellent linearity, accuracy, precision, specificity, the limit of detection, and limit of quantitation. Results: The chromatographic analysis indicated minimal degradation of LL-37 during the 12-week, with a predicted expiry time of 99 and 75 mo stored at 4 °C and 28 °C, respectively. Conclusion: LL-37 cream establishes good physical characteristics and stabilizes the active ingredient, especially at 4 °C and 28 °C storage. Therefore, the emulsion delivery system of LL-37 cream is harmless and stable as a novel alternative vehicle of LL-37. © 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd. |
Cream; High-performance liquid chromatography; LL-37; Stability |
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Innovare Academics Sciences Pvt. Ltd |
09757058 |
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Article |
Q3 |
238 |
17272 |
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89 |
Elbarbary N.S., dos Santos T.J., de Beaufort C., Wiltshire E., Pulungan A., Scaramuzza A.E. |
35725405100;37080460700;55346159500;6603809910;57192905981;6602617288; |
The Challenges of Managing Pediatric Diabetes and Other Endocrine Disorders During the COVID-19 Pandemic: Results From an International Cross-Sectional Electronic Survey |
2021 |
Frontiers in Endocrinology |
12 |
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735554 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119406902&doi=10.3389%2ffendo.2021.735554&partnerID=40&md5=0764f19be86686d381fa20013b41f50b |
Diabetes Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Instituto Hispalense de Pediatría, Vithas Almería, Almería, Spain; Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain; Diabetes Endocrine Care Clinique Pédiatrique (DECCP), Clinique Pédiatrique/Centre Hospitalier (CH) de Luxembourg, Luxembourg; Department Pediatric Endocrinology, Free University Hospital Brussels, Brussels, Belgium; Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand; Department of Child Health, Capital and Coast District Health Board, Wellington, New Zealand; Child Health Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Diabetes and Endocrinology Nutrition, Division of Pediatrics, Azienda Socio Sanitaria Territoriale (ASST) Cremona, “Ospedale Maggiore di Cremona”, Cremona, Italy |
Elbarbary, N.S., Diabetes Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; dos Santos, T.J., Instituto Hispalense de Pediatría, Vithas Almería, Almería, Spain, Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain; de Beaufort, C., Diabetes Endocrine Care Clinique Pédiatrique (DECCP), Clinique Pédiatrique/Centre Hospitalier (CH) de Luxembourg, Luxembourg, Department Pediatric Endocrinology, Free University Hospital Brussels, Brussels, Belgium; Wiltshire, E., Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand, Department of Child Health, Capital and Coast District Health Board, Wellington, New Zealand; Pulungan, A., Child Health Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Scaramuzza, A.E., Diabetes and Endocrinology Nutrition, Division of Pediatrics, Azienda Socio Sanitaria Territoriale (ASST) Cremona, “Ospedale Maggiore di Cremona”, Cremona, Italy |
Background: Frequency, dimensions, management, and outcomes of the COVID-19 pandemic in children with endocrine disorders and diabetes were assessed. Methods: A cross-sectional electronic survey was distributed to the global network of endocrine societies. Respondents’ professional and practice profiles, clinic sizes, their country of practice, and the impact of COVID-19 on endocrine diseases were investigated. Results: Respondents from 131 pediatric endocrine centers in 51 countries across all continents completed the survey. Routine check-ups and education were altered in most pediatric endocrine clinics. Over 20% of clinics experienced a shortage of critical medications or essential supplies. ICU treatment was required for patients with diabetes and COVID-19 in 21.2% of centers. In diabetes, 44% of respondents reported increased diabetic ketoacidosis episodes in newly diagnosed cases and 30% in established cases. Biopsychosocial and behavioral changes were explicitly reported to be occurring among pediatric patients with endocrine disorders. Conclusions: This large global survey conducted during the COVID-19 pandemic highlights that diabetes is more challenging to manage than any other pediatric endocrine disorder, with an increased risk of morbidity. Psychological distress due to COVID-19 needs to be recognized and addressed. The importance of close contact with healthcare professionals should be emphasized, and medical supplies should be readily available to all patients. © Copyright © 2021 Elbarbary, dos Santos, de Beaufort, Wiltshire, Pulungan and Scaramuzza. |
adrenal; children; COVID-19; diabetes; growth; obesity and metabolic syndrome; puberty; thyroid |
anemia; anxiety; Article; behavior change; bone metabolism; child; clinical practice; coronavirus disease 2019; cross-sectional study; depression; diabetes mellitus; diabetic ketoacidosis; eating disorder; education; endocrine disease; female; gender dysphoria; genetic screening; glucose blood level; glycemic control; human; insulin dependent diabetes mellitus; insulin treatment; major clinical study; male; mental stress; metabolic syndrome X; morbidity; pandemic; pediatric patient; pharmacist; physical activity; preschool child; questionnaire; school child; suicide attempt; teleconsultation; thyroid disease |
Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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90 |
Lydia A., Yassir Y., Hidayat R., Suwarto S. |
8451287200;57463407000;37067327300;8443626100; |
The Association Between Uric Acid and Symmetric Dimethylarginine Levels in the Patients Undergoing Twice-weekly Hemodialysis |
2021 |
Nephro-Urology Monthly |
13 |
4 |
e117476 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125057044&doi=10.5812%2fNUMONTHLY.117476&partnerID=40&md5=8d20b0dc3cfeb796c8879fd9e2fd2a30 |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Lydia, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yassir, Y., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hidayat, R., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Suwarto, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Uric acid (UA) levels are associated with increased risk of cardiovascular events and mortality in hemodialysis pa-tients. However, there are still conflicting data on the mechanism of increased risks related to uric acid levels. Objectives: This study assessed the association between uric acid levels and symmetric dimethylarginine (SDMA), as a marker of cardiovascular disease, in the subjects undergoing hemodialysis twice weekly. Methods: This was a cross-sectional study conducted in a tertiary hospital in Jakarta, Indonesia. We included all the adults who underwent hemodialysis twice weekly for at least three months in our hospital. Subjects already on uric acid lowering therapy, pregnant or lactating women and those with a history of malignancy were excluded. Uric acid and SDMA levels were measured at the same time in pre-dialysis venous blood samples. Bivariate analysis was performed using the Mann-Whitney U test or one-way ANOVA. Results: A total of 126 subjects were included. The median level of UA was 8.4 mg/dL (IQR: 2.6, min: 4.1, max: 13.6), and 72 subjects (57.14%) had UA levels of 8 mg/dL or higher. The median SDMA level was 535.5 (312.7) mmol/dL (min: 119.7, max: 1895.5). Subjects with UA levels >8 mg/dL had significantly higher SDMA levels compared to subjects with UA levels < 8 mg/dL (550.1 (IQR: 357.25) vs 491.35 (IQR: 181.1), P: 0.0475). Conclusions: In twice-weekly hemodialysis patients, UA levels above 8 mg/dL were associated with increased SDMA levels. © 2021, Author(s). |
Cardiovascular Risk Factors; Chronic Kidney Disease; Hemodialysis; Hyperuricemia; Uric Acid |
6 n,n' dimethylarginine; uric acid; adult; amino acid blood level; Article; cardiovascular disease; cardiovascular risk factor; cross-sectional study; diabetes mellitus; female; glomerulonephritis; hemodialysis; human; hypertension; major clinical study; male; middle aged; mortality; nutritional assessment; obesity; smoking; tertiary care center; underweight |
Kowsar Medical Institute |
22517006 |
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Article |
Q4 |
150 |
23185 |
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91 |
Renaldi K., Simadibrata M., Rahadiani N., Handjari D.R., William A., Sinuraya F., Makmun D. |
57190963547;23499598400;16426455700;56160657900;57209025962;57212478117;16638046900; |
Prognostic Value of COX-2, NF-κB, and Sp1 Tissue Expressions in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis |
2021 |
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology |
32 |
11 |
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956 |
970 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122454127&doi=10.5152%2ftjg.2021.211106&partnerID=40&md5=869f590f4b509a9d15f5495cd1423389 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Renaldi, K., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Simadibrata, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Rahadiani, N., Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; Handjari, D.R., Division of Gastroenterology and Hepato Billiary Pathology, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral HospitalJakarta, Indonesia; William, A., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Sinuraya, F., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Makmun, D., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo National General HospitalJakarta, Indonesia |
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is deadly cancer with a poor prognosis. Molecular prognostic markers are needed to predict the patient's survival. The cyclooxygenase-2 enzyme (COX-2) and its 2 major transcription factors--nuclear factorkappa B (NF-κB) and specificity protein 1 (Sp1)--are activated during inflammation caused by neoplasia. Several studies have investigated the association between the COX-2, NF-κB, and Sp1 tissue expressions with the patient's overall survival. Therefore, we conducted this systematic review and meta-analysis to evaluate those studies. METHODS: We searched for relevant articles from the MEDLINE database through June 2020. Studies were eligible if they included dichotomized tissue protein expression status and the overall survival as the outcome. We used RevMan and ProMeta programs to perform the meta-analysis. RESULTS: We identified 11 eligible studies. The meta-analysis showed that COX-2 tissue expression was associated with decreased overall survival (crude HR = 1.35; 95% CI, 1.05-1.74), although the result was not significant when controlling for other covariates. The NF-κB tissue expression was associated with decreased overall survival (crude HR = 2.18; 95% CI, 1.49-3.18), although it was not significant when controlling for other covariates. The Sp1 tissue expression showed significantly decreased overall survival even when adjusted with other covariates (aHR = 3.47; 95% CI, 1.52-7.94). The limitations included searching only for English publications and the substantial heterogeneity among the studies. CONCLUSION: COX-2, NF-κB, and Sp1 tissue expressions have the potential to be used as prognostic markers in PDAC. Further studies are still needed to clarify the associations. |
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cyclooxygenase 2; immunoglobulin enhancer binding protein; Sp1 protein, human; transcription factor Sp1; tumor marker; human; meta analysis; metabolism; pancreas carcinoma; pancreas tumor; prognosis; tissue distribution; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cyclooxygenase 2; Humans; NF-kappa B; Pancreatic Neoplasms; Prognosis; Sp1 Transcription Factor; Tissue Distribution |
NLM (Medline) |
21485607 |
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34872897 |
Article |
#N/A |
#N/A |
#N/A |
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93 |
Zizlavsky S., Anam K., Suwento R., Rahmawati I. |
57195721920;57474576600;55743638800;57372516200; |
The effects of Goldenhar Syndrome on hearing and speech development |
2021 |
Medical Journal of Malaysia |
76 |
6 |
|
946 |
949 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121118699&partnerID=40&md5=ccde190cb788d0255d331b7adfe1295c |
Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Zizlavsky, S., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Anam, K., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suwento, R., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmawati, I., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Goldenhar syndrome is a congenital abnormality with an incidence of 1 in 5,200 to 26,500 births. This syndrome is characterized by facial asymmetry, ear malformation, and/or defects in the eyes and vertebrae. The hearing disorder manifests as both conductive or sensorineural due to the abnormalities occurring in the inner and outer ear. We report a case of a 1-year-3-month-old child presenting with left anotia and right microtia, severe bilateral conductive hearing loss, and global delayed development. The patient was also found to have a hemifacial microsomia, a secundum atrial septal defect (ASD), and a ventricular septal defect (VSD). The patient was advised to use hearing aids and participate in speech therapy. The management of this Goldenhar syndrome patient should be done comprehensively, appropriate to the abnormalities found to achieve the best result. © 2021, Malaysian Medical Association. All rights reserved. |
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anterior inferior cerebellar artery; Article; audiology; babbling; blue light; brainstem evoked response audiometry; case report; clinical article; conduction deafness; cranial nerve paralysis; dyspnea; ear malformation; electrophysiological response; face asymmetry; face deformity; Goldenhar syndrome; hearing; hearing disorder; hearing examination; hearing function; heart atrium septum defect; heart disease; heart ventricle septum defect; hemifacial microsomia; human; hyperbilirubinemia; infant; lagophthalmos; loud noise; male; micrognathia; microtia; motor development; nuclear magnetic resonance imaging; parasystolic murmur; perception deafness; ptosis (eyelid); radiodiagnosis; speech development; speech therapy |
Malaysian Medical Association |
03005283 |
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34806693 |
Article |
Q4 |
193 |
19818 |
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94 |
Subahar R., Susanto L., Aidilla R., Aulia A.P., Yulhasri Y., Winita R., Lubis N.S., Sari I.P. |
6508197883;6507704130;57365800900;57366528800;57225180520;57220782528;57222661567;57197543698; |
In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron microscopic changes in lice |
2021 |
Veterinary World |
14 |
11 |
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3065 |
3075 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120814548&doi=10.14202%2fvetworld.2021.3065-3075&partnerID=40&md5=1d1646983a8b7f7da98a7d4f5896e795 |
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia |
Subahar, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Susanto, L., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Aidilla, R., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Aulia, A.P., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia; Winita, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Lubis, N.S., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia |
Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). Materials and Methods: The adult stages of P. h. capitis were collected from patients exposed to 1% permethrin and three different concentrations of 6-paradol (0.00005%, 0.0001%, and 0.00015%) using a filter paper diffusion bioassay. Healthy P. h. capitis adults served as the control. The in vitro bioassays were conducted after 10, 20, 30, and 60 min of exposure. The activities of acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase were analyzed. Physical changes in the lice were analyzed using SEM. Results: Permethrin and 6-paradol exhibited low toxicity against the lice. At 60 min, 1% permethrin had killed 36.7% of the lice present, while 6-paradol had killed 66.7-86.7%. Permethrin induced significantly elevated AChE, GST, and oxidase activity; 6-paradol also caused significantly elevated AChE, GST, and oxidase activity. Permethrin did not cause any ultrastructural morphological changes on the lice, while 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. Conclusion: This in vitro experimental of P. h. capitis is the first study to report P. h. capitis in East Jakarta shows complete resistance to permethrin and 6-paradol, and to describe the associated increase in AChE, GST, and oxidase activity. It was observed that 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. © 2021 Veterinary World. All rights reserved. |
6-paradol; Detoxifying enzyme; Electron microscopy; Pediculus humanus capitis; Permethrin; Resistance |
6 paradol; acetylcholinesterase; chitin; glutathione transferase; oxidoreductase; permethrin; phenol derivative; unclassified drug; Article; bioassay; controlled study; detoxification; diffusion; enzyme activity; enzyme linked immunosorbent assay; hair loss; LT50; LT90; nonhuman; Pediculus humanus capitis; scanning electron microscopy; ultrastructure |
Veterinary World |
09728988 |
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Article |
Q2 |
550 |
9187 |
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