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No records
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286 |
Wijaya I.P. |
57193731572; |
The Importance of Selecting Permanent Pacemaker, Evaluating the Heart and Assessing Quality of Life in Cardiac Patient |
2021 |
Acta medica Indonesiana |
53 |
3 |
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243 |
244 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117859074&partnerID=40&md5=9e57130d3901679cfdd2331bb124a29a |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Wijaya, I.P., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
The use of pacemakers is necessary for patients with symptomatic bradycardia. Pacemaker implantation also acts as a life-saving procedure. However, there are several reports that patients with a pacemaker (the most widely used pacemaker is on the right ventricle, known as single chamber pacemaker) had disturbances in left ventricle contraction lead to left ventricular systolic dysfunction. Global Longitudinal Strain (GLS) Echocardiography can confirm these left ventricular disturbances. Echocardiography examination is best carried out before and after single-chamber PPM implantation. This study compares PPM placement in apical Right Ventricle (RV) and Right Ventricular Outflow Tract (RVOT) and compares paced QRS duration 150 ms and > 150 ms. Pacing burden >40% causes subclinical left ventricular systolic dysfunction after a month of PPM implantation with decreased GLS in apical RV pacing.This study gives additional information that PPM placement is preferably in RVOT with some specific settings. However, there are many ways to reduce the effects of impaired left ventricular function due to lead installation on the PPM single-chamber device. By using the PPM device which has a dual chamber, the leads will be placed in RVOT and also in the right atrium with atrial-ventricle synchronization. The aim is to avoid impaired left ventricular pump function as supported by a systematic review which states the superiority of dual-chamber PPM over single-chamber PPM in reducing atrial fibrillation and pacemaker syndrome. In the importance of quality of life related to heart disease, the Indonesian version of the MacNew questionnaire can be used. This questionnaire seeks the quality of life of patients with coronary heart disease after revascularization surgery and has undergone rehabilitation. Another important thing is the suitability of the adaptation to the original English version. |
cardiac patient; global longitudinal strain; MacNew questionnaire; pacemaker |
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NLM (Medline) |
01259326 |
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34611061 |
Article |
Q3 |
321 |
14162 |
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287 |
Lydia A., Priantono D., Harimurti K., Alwi I. |
8451287200;57219443427;23473513200;15055173800; |
The Relationship between Folic Acid and Vitamin B12 Serum Levels with High Sensitivity C-reactive Protein and Homocysteine in Chronic Hemodialysis Patients: A Cross-sectional Study |
2021 |
Acta medica Indonesiana |
53 |
3 |
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282 |
290 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117858308&partnerID=40&md5=30f4d1e6b0ba005c917362c78562ed5b |
Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo National HospitalJakarta, Indonesia |
Lydia, A., Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo National HospitalJakarta, Indonesia; Priantono, D.; Harimurti, K.; Alwi, I. |
BACKGROUND: Folic acid (FA) and vitamin B12 treatment have been routinely prescribed to lower serum homocysteine levels and to reduce inflammation. However, no study has been conducted to determine serum folic acid (SFA) and vitamin B12 (B12) levels in patients who have twice-weekly hemodialysis. The aim of our study was to assess serum folate and B12 levels in chronic hemodialysis patients and their relationship with hsCRP and homocysteine levels. METHODS: Our study was a cross-sectional study involcing patients who had twice-weekly hemodialysis in Dr Cipto Mangunkusumo National Hospital Jakarta, Indonesia. Predialysis blood samples were taken to measure SFA, B12, homocysteine and hsCRP levels. Patients with medical conditions affecting the assays were excluded. Spearman correlation was used to compare variables. RESULTS: Eighty subjects enrolled in this study. Among those of non-given folic acid and vitamin B-12 supplementation, only 3.85% of subjects had low folic acid levels, and none had low vitamin B12 levels. A moderate negative correlation between serum folic acid and homocysteine level (p≤0.001; r=-0.42) and a weak correlation between serum vitamin B12 and homocysteine level (p=0.009; r=-0.29) was found. Among the high-risk cardiovascular group (CRP>3, n=49), there is a moderate negative correlation between serum folic acid and homocysteine level (p≤0.001; r=-0.561) and a weak negative correlation between vitamin B12 and homocysteine level (p=0.018; r=-0.338). CONCLUSION: There is a significant negative correlation between serum vitamin B12 and folic acid with homocysteine levels, especially in high-risk cardiovascular group. |
cardiovascular; chronic hemodialysis; CKD; Folic acid; hsCRP; morbidity; mortality; vitamin B12 |
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NLM (Medline) |
01259326 |
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34611067 |
Article |
Q3 |
321 |
14162 |
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288 |
Atmakusuma T.D., Kalwani R., Nasution S.A., Rumende C.M. |
57216961785;57310670300;57189373134;14325966300; |
Correlation of Serum Ferritin and Cardiac Iron Toxicity with Cardiac Function in Transfusion Dependent Beta-Thalassemia Major Patients |
2021 |
Acta medica Indonesiana |
53 |
3 |
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291 |
298 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117853935&partnerID=40&md5=508f3a43041f0289262b56448c4ae575 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo HospitalJakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo HospitalJakarta, Indonesia; Kalwani, R.; Nasution, S.A.; Rumende, C.M. |
BACKGROUND: Cardiac iron toxicity is a major cause of mortality in transfusion-dependent beta-thalassemia major patients. The main modality for detecting cardiac iron toxicity is MRI T2* with limited availability. This study aims to obtain iron toxicity profiles in transfusion-dependent beta-thalassemia patients; to see a correlation between iron toxicity and cardiac function. METHODS: We conducted a cross-sectional study at the Adult Thalassemia Polyclinic of Cipto Mangunkusumo Hospital, Indonesia from December 2017 to March 2018. We performed the statistical analysis using Pearson/Spearman Test comparing MRI T2* values with ejection fraction and E/A ratio. RESULTS: The median of 4-months mean of ferritin levels was 5130 ng/mL. The mean for cardiac T2* was 24.96 ms. Severe cardiac hemosiderosis (mean cardiac MRI T2* < 10 ms) occurred in 11.3% of the subjects. There was weak correlation between serum ferritin with cardiac iron toxicity (r=-0.272, p=0.032) and ejection fraction (r=-0.281, p=0.013). But, there was no correlation between cardiac iron toxicity with ejection fraction and E/A ratio. CONCLUSION: Serum ferritin correlated weakly with cardiac iron toxicity and cardiac systolic function. Meanwhile, there was no correlation between cardiac iron toxicity with cardiac systolic and diastolic function. |
cardiac iron toxicity; cardiac MRI T2*; diastolic function; serum ferritin; systolic function |
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NLM (Medline) |
01259326 |
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34611068 |
Article |
Q3 |
321 |
14162 |
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289 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Bardosono S., Sungkar S., Rachmat J., Hediyati M., Silalahi T. |
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;21933841000;57016857300;6507225348;57310558800;56275255400; |
Wound Healing in Diabetic Foot Ulcer Patients Using Combined Use of Platelet Rich Fibrin and Hyaluronic Acid, Platelet Rich Fibrin and Placebo: An Open Label, Randomized Controlled Trial |
2021 |
Acta medica Indonesiana |
53 |
3 |
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268 |
275 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117847076&partnerID=40&md5=089bf13006cbe4a09ad0a915462eec3b |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Kartika, R.W., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Alwi, I.; Suyatna, F.D.; Yunir, E.; Waspadji, S.; Immanuel, S.; Bardosono, S.; Sungkar, S.; Rachmat, J.; Hediyati, M.; Silalahi, T. |
BACKGROUND: Autologous platelet-rich fibrin (A-PRF) is an adjunctive method for diabetic foot ulcer (DFU) in addition to glycaemic control and debridement. This study aimed to evaluate the role of A-PRF + hyaluronic acid (HA), A-PRF and sodium chloride 0.9% (control) in DFU wound healing. Nowaday, the use of PRF autologous consider as adjuvant therapy in DFU treatment. METHODS: This open-label randomized controlled trial was conducted at Koja District Hospital and Gatot Soebroto Hospital from July 2019 to April 2020. DFU patients with wound duration of three months, Wagner-2, and ulcer size < 40 cm2 were recruited and randomly assigned into A-PRF + AH, A-PRF and control group. On day-0, day-3 and day -7, samples and photographs were taken. Samples were analysed with ELISA and photographs were analysed with ImageJ to calculate granulation index (GI). Statistical analysis was performed using SPSS version 20. RESULTS: Topical therapy with A-PRF + AH was associated with a significant increase in VEGF from day 0 (232.8 pg/mg) vs day 7 (544.5 pg/mg) compared to A-PRF on day 0 (185.7 pg/mg) vs day 7 (272.8 pg/mg), and the controls on day 0 (183.7 pg/mg) vs day 7 (167.4 pg/mg). On evaluation of VEGF swab, there is increasing significantly in A-PRF+HA group compare others group in day -3 ( p=0.022) and day -7 (p= 0.001).In the A-PRF + AH group, there was a significant decrease in IL-6 from day 0 (106.4 pg/mg) vs day 7 (88.7 pg/mg) compared with PRF on day 0 (91.9 pg/mg) vs day 7 (48,8 pg/mg). IL-6 was increased in the control group from day 0 (125.3 pg/mg) vs day 7 (167.9 pg/mg). On evaluation of IL-6 swab, there is decreasing significantly in A-PRF+HA group compare others group in day -7 (p= 0.041). CONCLUSION: The PRF + HA combination increased angiogenesis and reduced inflammation in DFUs and may represent a new DFU therapy. |
diabetic foot ulcer; hyaluronic acid; platelet-rich fibrin |
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NLM (Medline) |
01259326 |
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34611065 |
Article |
Q3 |
321 |
14162 |
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292 |
Iman R.P., Junita T., Rachman R.I., Syam A.F. |
57218324172;57310672300;57310137500;8443384400; |
Risk factor, diagnosis, and current treatment of H. pylori Infection in Indonesia: A Literature Review |
2021 |
Acta medica Indonesiana |
53 |
3 |
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331 |
338 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117760916&partnerID=40&md5=ce13806d99f6c0a46477f70903de63ef |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Iman, R.P., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Junita, T.; Rachman, R.I.; Syam, A.F. |
Helicobacter pylori (H. pylori) infection has become an emerging problem in Indonesia despite its relatively low prevalence as opposed to other Southeast Asian and Asian countries. Strains containing less virulent genotypes predominantly found in Indonesia is suggested to be the rationale for why the disease prevalence, as well as its gastric cancer complication, remain inferior in respect of neighboring counterparts. Although endoscopic evaluation is still necessary to determine the gastric mucosal status of those infected with H. pylori, the infection itself can be easily diagnosed with test-and-treat strategy especially in areas with limited resources. Several findings revealed high rates of antibiotic resistance varying among Indonesian regions and ethnicities, suggesting that triple therapy regimen may not be suitable for all population. Whereas treatment should be based on the pattern of resistance in respected region, novel regimens involving furazolidone, rifabutin, and sitafloxacin are proposed as potential drugs of choice to eradicate H. pylori infection. In order to determine the adequate approach for H. pylori infection in Indonesia, further multicenter studies involving larger sample size should be conducted. |
current treatment; diagnosis; Helicobacter pylori; infection; risk factor |
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NLM (Medline) |
01259326 |
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34611074 |
Article |
Q3 |
321 |
14162 |
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295 |
Sugiharto P., Ramlan A.A.W. |
57286412100;57195941841; |
Effectiveness of mindfulness-based intervention technique in reducing stress levels of anesthesiology and intensive therapy residents |
2021 |
Bali Journal of Anesthesiology |
5 |
3 |
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166 |
170 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116416960&doi=10.4103%2fbjoa.bjoa_251_20&partnerID=40&md5=ec537b920b0bac4177ea8de114c87660 |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Sugiharto, P., Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: An anesthesiologist is expected to be able to manage intraoperative crises that can occur at any time. We aimed to determine the effectiveness of mindfulness-based intervention (MBI) technique in reducing stress levels of anesthesiology and intensive therapy residents at the Faculty of Medicine, University of Indonesia. Materials and Methods: This research was an experimental study with paired one group design. The MBI program lasted 4 weeks, consisted of one formal face-to-face training and 4 weeks of informal training (homework). Thirteen study subjects met the inclusion criteria and did not enter the exclusion criteria. One study subject was excluded because the subject did not complete the informal training. Data collection on the Perceived Stress Scale 10-Item (PSS-10) was conducted before and after training. Results: The average age of study subjects was 29.75 years; 75% are women. Four participants were in the 1 st year of education (33%), 3 participants were in the 2 nd year of education (25%), 2 participants were in the 3 rd year of education (16.67%), and 3 participants were in the 4 th year of education (25%). PSS-10 score in the study subjects significantly decreased after applying the MBI technique for 4 weeks (P = 0.001). Conclusion: MBI is effective in reducing stress levels of anesthesiology and intensive therapy residents at the-blinded. © 2020 Bali Journal of Anesthesiology | Published by Wolters Kluwer-Medknow. |
Anesthesiologist; mindfulness; resident; stress |
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Wolters Kluwer Medknow Publications |
25492276 |
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Article |
#N/A |
#N/A |
#N/A |
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296 |
Pudjiadi A.H., Pramesti D.L., Pardede S.O., Djer M.M., Rohsiswatmo R., Kaswandani N. |
18435202300;57286438600;57210394278;12771087900;55533574600;57195941745; |
Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study |
2021 |
International Journal of Critical Illness and Injury Science |
11 |
3 |
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117 |
122 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116401748&doi=10.4103%2fIJCIIS.IJCIIS_98_20&partnerID=40&md5=c4a8675dca5d2e706bb5225b224574e6 |
Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pramesti, D.L., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pardede, S.O., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Djer, M.M., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Rohsiswatmo, R., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Mortality in pediatric septic shock remains very high. Vasoactive-inotropic score (VIS) is widely used to predict prognosis in patients with heart disease. It is a simple method that was initially used as a predictor of morbidity and mortality in postoperative patients with congenital heart diseases. Previous reports showed that high VIS score was associated with high mortality in pediatric sepsis. However, its discriminative value remains unclear. We aim to explore the discriminative value of VIS in predicting mortality in pediatric septic shock patients. Methods: We conducted a retrospective cohort study on medical records of septic shock patients who received care in the pediatric intensive care unit (PICU). We screened medical records of pediatric patients which were diagnosed with septic shock and admitted to the PICU and received vasoactive/inotropic score for more than 8 h. Other supporting examination results were recorded, such as organ function evaluation for calculation of Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. The outcome of patients was recorded. The receiver operating curve was constructed to calculate the area under the curve (AUC), sensitivity, and specificity of each cutoff point. Results: We obtained the optimum cutoff point of VIS > 11 with 78.87% sensitivity and 72.22% specificity. AUC positive was 0.779 (P < 0.001); predictive value and negative predictive value were 91.80% and 46.43%, respectively. Conclusion: VIS > 11 has a good ability to predict mortality in children with septic shock. © 2021 International Journal of Critical Illness and Injury Science | Published by Wolters Kluwer-Medknow. |
Mortality; pediatrics; sepsis; vasoactive-inotropic score |
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Wolters Kluwer Medknow Publications |
22295151 |
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Review |
Q3 |
274 |
15730 |
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298 |
Sutandi N., Lee F. |
57201654034;57262177400; |
Vitreoretinal abnormalities in corona virus disease 2019 patients: What we know so far |
2021 |
Taiwan Journal of Ophthalmology |
11 |
3 |
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232 |
243 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115110995&doi=10.4103%2ftjo.tjo_30_21&partnerID=40&md5=36ea488504463bec350d4e4cb30186ed |
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Sutandi, N., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Lee, F., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
The coronavirus disease 2019 (COVID-19) has become a global pandemic since December 2019. Although COVID-19 primarily affects the respiratory systems, it has become abundantly clear that it involves multiple organs including the heart, kidney, skin, and brain. Neuro-ophthalmic signs and anterior segment inflammation of the eyes were documented in COVID-19 patients recently. Small but growing number of literatures has also reported the cases of new onset vitreoretinal disorders related to COVID-19 infection. A comprehensive search from four online databases was done. Findings show vitreoretinal involvement in COVID-19 patients including the central retinal vein occlusion, central retinal artery occlusion, reactivation of previous uveitis, chorioretinitis, macular hemorrhage, acute macular neuroretinopathy, paracentral acute middle maculopathy, vitritis with outer retinal abnormalities, varicella zoster virus-related acute retinal necrosis in immunocompromised patient, and other posterior segment pathological changes. The hypotheses for potential pathogenesis of these manifestations are direct viral ocular infection and thromboembolic complications secondary to the hyperinflammatory response. This is the first review article, which provides an overview of current evidence regarding the vitreoretinal manifestations in COVID-19 patients. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
COVID-19; funduscopy; posterior segment; SARS-CoV-2; vitreoretinal abnormalities |
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Wolters Kluwer Medknow Publications |
22115056 |
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Review |
Q3 |
519 |
9760 |
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303 |
Samara T., Wibowo H., Liem I., Prijanti A., Andrijono A. |
57208256339;57217690943;55802927800;57190863386;57208264133; |
Cullin 1 as a proangiogenic factor and its relationship with vascular endothelial growth factor and p21 are associated with the length of gestational age of pre-eclampsia |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
2 |
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140 |
144 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111296351&doi=10.4103%2fjnsbm.JNSBM-123-20&partnerID=40&md5=10efc582ba2ed72d7813100c2ebbc2d5 |
Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Samara, T., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Wibowo, H., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Liem, I., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prijanti, A., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andrijono, A., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Cullin 1 (CUL1), vascular endothelial growth factor (VEGF), and p21 are proteins that play a role in pregnancy. CUL1 and VEGF are proangiogenic factors, whereas p21 is an antiangiogenic factor. An imbalance between proangiogenic and antiangiogenic factors is one of the various factors that cause pre-eclampsia (PE). The aim of this study was to analyze CUL1 levels in the relationship with VEGF levels and p21 levels based on gestational age at delivery in PE. Materials and Methods: This was a cross-sectional study of 70 placentas from PE patients divided in two groups of gestational age at delivery: <34 weeks and ≥34 weeks. Levels of CUL1, VEGF, and p21 were examined by the enzyme-linked immunosorbent assay technique. Statistical analysis was assessed by Spearman correlation test and Chi-square test, with a significant P < 0.05. Results: Low levels of CUL1 and low levels of VEGF were related with <34 weeks of gestational age at delivery, whereas high levels of CUL1 and high levels VEGF were related with ≥34 weeks of gestational age at delivery. There was a negative correlation between the high ratios of p21/CUL1 and <34 weeks of gestational age at delivery in PE. Conclusions: Low levels of CUL1 and low levels VEGF and high ratios of p21/CUL1 were associated with <34 weeks of gestational age at delivery in PE. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Cullin 1; gestational age; p21; pre-eclampsia; vascular endothelial growth factor |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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307 |
Wiguna T., Ismail R.I., Kaligis F., Minayati K., Murtani B.J., Wigantara N.A., Pradana K., Bahana R., Dirgantoro B.P., Nugroho E. |
24367785700;55996895500;36604651700;57218681686;57216652176;57218679014;57220165625;56400946100;57202082268;56493037400; |
Developing and feasibility testing of the Indonesian computer-based game prototype for children with attention deficit/hyperactivity disorder |
2021 |
Heliyon |
7 |
7 |
e07571 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110552291&doi=10.1016%2fj.heliyon.2021.e07571&partnerID=40&md5=8eca39aaa9e8ed828955cacd6838b22f |
Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Kummara Game Design Studio, Bandung, West Java, Indonesia |
Wiguna, T., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wigantara, N.A., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pradana, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bahana, R., Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Dirgantoro, B.P., Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Nugroho, E., Kummara Game Design Studio, Bandung, West Java, Indonesia |
The aim of this study was to develop an Indonesian computer-based game prototype, including feasibility testing, targeted on attention deficit/hypersensitivity disorder (ADHD) clinical symptoms and executive function. The study comprised five steps. The first to third steps used an exploratory qualitative research design. The Delphi technique with FGD was applied to collect qualitative data. During the study, seven experts participated in ten FGDs. Feasibility testing was conducted as a one group pre- and post-test design that included ten children with drug-naïve ADHD without other mental or physical disorders. Feasibility data were collected before and after 20 training sessions with the Indonesian computer-based game prototype. The framework analysis was performed for qualitative data. Quantitative data were analyzed using the paired t-test, Pearson's correlation and Spearman's rank-order correlation. Outputs of the exploratory qualitative study were the Indonesian computer-based game prototype constructs and general agreements of the prototype,. The Indonesian computer-based game prototype construct comprised six components: reward-related processing, control inhibition, improved sustained attention, specific timing, increased arousal, and improved emotional regulation. After 20 sessions of training, several indicators decreased significantly, such as CATPRS-teacher rating (18.5 [5.31] vs. 12.9 [5.51], p = 0.047), BRIEF-GEC (64.80 [10.21] vs. 57.50 [7.51], p = 0.02), BRIEF-MI (66.1 [7.61] vs. 58.4 [7.56], p = 0.014), BRIEF-Initiate (66.6 [10.15] vs. 54.1 [6.49], p = 0.008), BRIEF-Working Memory (68.0 [6.89] vs. 60.9 [10.05], p = 0.02), and BRIEF-Organization of Material (60.7 [12.88] vs. 49.3 [11.79], p = 0.04). There was a low to moderate correlation between CATPRS-teacher and -parent rating and several BRIEF domains. Feasibility testing output also included the training procedure guideline. The present study indicated that the Indonesian computer-based game prototype could be used as a framework to develop a fixed computer-based game intervention for children with ADHD. However, further randomized controlled studies need to be conducted to show its effectiveness. © 2021 The Author(s) |
ADHD; Behavioral Rating Inventory for Executive Function; Computer-based game; Connors Abbreviated Teacher; Executive function; Indonesia |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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