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251 |
Purwoto G., Surya I.U., Saroyo Y.B., Rustamadji P., Harzif A.K. |
14720170400;57226288663;57164888400;55321572200;57191493435; |
Massive obstetric haemorrhage on post caesarean subtotal hysterectomy due to late detection of occult placenta percreta: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106225 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111073049&doi=10.1016%2fj.ijscr.2021.106225&partnerID=40&md5=8fb12792281a054a4a64365989402d15 |
Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia; Department Anatomical Pathology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo, Indonesia |
Purwoto, G., Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia; Surya, I.U., Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia; Saroyo, Y.B., Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia; Rustamadji, P., Department Anatomical Pathology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo, Indonesia; Harzif, A.K., Department of Obstetric and Gynecology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Placenta accreta syndrome is a significant cause of maternal mortality and morbidity. Therefore, a multidiscipline approach is essential to overcome this life-threatening disorder for the mother and fetus. Presentation of case: A 32-year-old women gravida 3 parity 2, 34 weeks gestation come due to recurrent antepartum haemorrhage. She had twice prior caesarean section. Ultrasound assessment suggests total placenta previa and elevating suspicion to placenta accreta. However, intraoperatively its sign is unavailable. Although we have done subtotal hysterectomy, massive bleeding still occurring. Therefore, we present management of unexpected placenta percreta. Discussion: Management of unexpected placenta percreta involves prenatal diagnosis, haemoglobin optimization, surgical management anticipating haemorrhage, dedicated maternal ICU, blood bank providing massive transfusion and blood component. Conclusion: Close monitoring is important in catastrophe management of Placenta Accreta Syndrome. © 2021 The Authors |
Case report; Focal placenta accreta; Hypogastric artery ligation; Placenta previa; Villi chorion |
C reactive protein; creatinine; fresh frozen plasma; hemoglobin; procalcitonin; thrombocyte concentrate; urea; adult; amnion fluid; antepartum hemorrhage; artery ligation; Article; blood cell count; breech presentation; broad ligament; case report; cervicotomy; cesarean section; clinical article; diastolic blood pressure; dissection; echography; emergency surgery; erythrocyte count; erythrocyte transfusion; female; fetus heart rate; fetus weight; follow up; hematocrit; hemoglobin blood level; human; hysterectomy; internal iliac artery; intraoperative period; laparotomy; leukocyte count; neutrophil lymphocyte ratio; placenta accreta; placenta previa; plasma transfusion; recurrent disease; round ligament; systolic blood pressure; umbilical artery; uterine atony; uterus contraction; vagina bl |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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253 |
Reksodiputro M.H., Hutauruk S.M., Koento T., Fardizza F., Hakim R.Y.R., Audindra S., Yosia M. |
35090488800;57205105620;35090124600;55091031700;57226286398;57222006228;57204933098; |
Randomised clinical trial: Effect of administering platelet-rich fibrin to autologous fat tissue in injection laryngoplasty for vocal cord paralysis |
2021 |
Annals of Medicine and Surgery |
68 |
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102564 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111006340&doi=10.1016%2fj.amsu.2021.102564&partnerID=40&md5=55d6b3d1b486bec46a872ef4e755dd23 |
Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia |
Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Hutauruk, S.M., Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Koento, T., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Fardizza, F., Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Hakim, R.Y.R., Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Audindra, S., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia |
The vocal cord in humans is essential in producing voice used in communication and interaction between us. Vocal cord paralysis causes dysphonia, which interferes with communication, causing disruptions towards social activity and daily activities. One of the managements for vocal cord paralysis is medialization and augmentation of the vocal cord through injection laryngoplasty. Autologous fat is one of the best fillers used in this procedure, but it is highly absorbable and can be reabsorbed very quickly when injected into body tissues. Platelet Rich Fibrin (PRF) is a biomaterial consisting of growth factors that are thought to improve fat tissue viability by increasing adipogenesis and angiogenesis. Improvement in fat viability will improve clinical outcomes after the laryngoplasty procedure, potentially reducing the number of repeated injections needed to achieve a satisfactory resolution to vocal cord paralysis. The study evaluates a combination of PRF and autologous microlobular fat compared with autologous microlobular fat alone on laryngoplasty. This single-blinded randomised control trial recruit a total of 18 patients, which are then randomised into the treatment and control groups. The evaluation was done via computerized acoustic analysis/Multidimensional Voice Program (MDVP) parameters and maximum phonation time. The MDVP results and maximum phonation time in both groups showed clinical improvement after the operation with no statistically significant differences. © 2021 The Authors |
Autologous fat; Injection laryngoplasty; Platelet-rich fibrin; Vocal cord paralysis |
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Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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254 |
Wahyudi M., Alaztha Z. |
57053464800;57219572320; |
Chondrosarcoma arising in monostotic fibrous dysplasia treated with total femur resection and megaprothesis: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106194 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110717734&doi=10.1016%2fj.ijscr.2021.106194&partnerID=40&md5=45372bc574217c458407b12ac52c18ba |
Department of Orthopaedic and Traumatology, Fatmawati General Hospital, Indonesia; Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia |
Wahyudi, M., Department of Orthopaedic and Traumatology, Fatmawati General Hospital, Indonesia; Alaztha, Z., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Fibrous dysplasia is tumor like lesions of bone which develop as substitution of bone by an expansion of fibrous connective tissue mixed with hard trabeculae. Chondrosarcomas is one of common malignant primary bone tumor derived from heterogenous group of neoplasm producing chondroid matrix. Chondrosarcoma arising in fibrous dysplasia, especially in monostotic fibrous dysplasia is a very rare case. Case report: A 54-year-old male presented with chief complaint of pain on left thigh. Patient with history of pathological fracture on left femoral diaphysis 3 years ago due to fibrous dysplasia and had underwent curettage, open reduction, and internal fixation at other hospital. Plain radiography revealed expansive lytic lesion, interrupted periosteal reaction with plate and screw attached to the lesion, and soft tissue mass. MRI T2FS sequence showed hyperintense mass extending from subtrochanteric to distal of left femoral diaphysis. Histopathological result from biopsy suggested chondrosarcoma. Conclusions: Malignant transformation of monostotic type was less frequently compared to polyostotic type. Among all malignant transformation cases, alteration to chondrosarcoma was more scarce than other malignancy such as osteosarcoma and fibrosarcoma. Wide surgical margin and reconstruction in chondrosarcoma provide good local control and functional outcome. © 2021 The Authors |
Chondrosarcoma; Malignant transformation; Monostotic fibrous dysplasia; Total femur resection |
polyethylene terephthalate; abduction; adult; anamnesis; Article; blood examination; bone biopsy; bone radiography; cancer surgery; cartilage matrix; case report; chondrocyte; chondrosarcoma; clinical article; curettage; femoral shaft; femoral vein; femur; femur diaphysis; femur fracture; femur shaft fracture; follow up; general hospital; greater trochanter; histopathology; human; human cell; incision; laboratory; leg pain; length of stay; male; middle aged; monostotic fibrous dysplasia; nuclear magnetic resonance imaging; open fracture reduction; operative blood loss; orthopedic surgery; osteosynthesis; pathologic fracture; physical examination; psoas muscle; rectus femoris muscle; sartorius muscle; superficial femoral artery; supine position; surgical margin; thigh; tibial tuberosity; va |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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255 |
Surachman A.J.D., Yanuarso, Akbar D.L. |
57222404106;57222408215;57219271823; |
Corrigendum to “Emergency decompression and stabilization of 1st thoracic spinal cord injury and sacral fracture in a Covid-19 patient: A case report” [Int. J. Surg. 81 (2021) 105670] (International Journal of Surgery Case Reports (2021) 81, (S221026122100170X), (10.1016/j.ijscr.2021.105670)) |
2021 |
International Journal of Surgery Case Reports |
85 |
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106162 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110716581&doi=10.1016%2fj.ijscr.2021.106162&partnerID=40&md5=d755a2c74f6f517c9ab61ce17d1d60b7 |
Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo National Central General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Surachman, A.J.D., Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Yanuarso, Orthopaedics and Traumatology Department, Indonesia Army Central Hospital, Jakarta, Indonesia; Akbar, D.L., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo National Central General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The authors regret: [1] The published sentence should have read: “For the pubic diastasis, we did not put any fixation since the diastasis was 1 cm (Fig. 4). When we did the follow up, there was unstable on the diastasis, then we did internal fixation on it and the result of the post surgery was evaluated by pelvic radiograph (Fig. 5) [9].” [2] Fig. 5 should have been published as follows: [3] The authors wish to add the following acknowledgement: “Nadya Zaragita, resident of neurosurgery department of Faculty of Medicine, Universitas Indonesia for making illustration of sacral fracture fixation method.” The authors would like to apologise for any inconvenience caused. © 2021 |
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erratum |
Elsevier Ltd |
22102612 |
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Erratum |
Q3 |
232 |
17549 |
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257 |
Moegni F., Kouwagam A.D. |
55450456100;57225978823; |
Secondary pyosalpinx after reconstructive surgery of vaginal agenesis patient with bilateral hematosalpinx: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106166 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109875443&doi=10.1016%2fj.ijscr.2021.106166&partnerID=40&md5=3efbc39e25d5804ce8b775670c949c8c |
Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Moegni, F., Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kouwagam, A.D., Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Congenital or hypoplasia vaginal agenesis is a very rare condition caused by the failure of developmental Mullerian ducts. The prevalence is 0.001%–0.025% populations. This condition often misdiagnosed because the symptom does not appear. Acute symptoms such as abdominal pain may occur due to the obstruction of retrograde menstrual flow. In this case, we presented a case complex management of vaginal atresia with pyosalpinx, hematometra and bilateral hematosalpinx. Presentation of case: A 12 years old teenager, non-sexually active, complained cyclic abdominal pain that worsening in seven months before admission. Patient never had menstrual blood flow during her life. Patient was diagnosed with hematometra, hematocolpos, bilateral hematosalpinx and distal vaginal agenesis. Amnion graft neovagina was performed. Five days after surgery, patient started to have fever. On the seventh days after surgery, amnion graft was removed. The next two days patient still had fever. Because of continuous fever, patient was test of COVID 19. The result was positive. On the eleventh days after the first surgery, patient complained abdominal pain VAS 3–4. Patient was diagnosed with pyosalpinx by ultrasound examination. Laparotomy was done performing adhesiolysis, bilateral salpingectomy, and omentectomy. Discussion: In our case vaginal reconstruction surgery from vaginal approach has been done without management of the bilateral hematosalpinx because the consideration of small caliber of bilateral hematosalpinx. But then complications were developed when vaginal canal was opened, bilateral hematosalpinx were transformed into bilateral pyosalpinx and continue to developed into bilateral tubal abscess. We assume during this process, the bacteria from vagina could fastly infecting the blood and transformed it into pus and grew until tubal abscess. Conclusion: The surgical intervention in vaginal agenesis must be considered as a treatment and not only focus on the reconstruction. Laparoscopy or laparotomy may offered as options for combination treatment with vaginal approach reconstructive surgery for vaginal agenesis with obstruction complications such as hematometra and hematosalpinx to prevent the worst condition like ascending infection or misdiagnosed other severe conditions. © 2021 The Authors |
Case report; Hematosalpinx complication; Neovagina; Secondary pyosalpinx; Vaginal agenesis |
antibiotic agent; abdominal pain; abscess; adhesiolysis; amnion graft neovagina; antibiotic therapy; Article; bilateral hematosalpinx; bilateral tubal abscess; case report; child; clinical article; coronavirus disease 2019; echography; female; fever; hematocolpos; hematometra; human; laparotomy; omentectomy; primary amenorrhea; salpingectomy; school child; secondary pyosalpinx; surgical technique; uterine tube disease; vagina aplasia; vagina reconstruction; visual analog scale |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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258 |
Fudla H., Mudjihartini N., Khusun H. |
57225017143;57191055759;6506676401; |
Effect of four weeks of 5:2 intermittent fasting on energy intake and body mass index among obese male students aged 18-25 |
2021 |
Obesity Medicine |
25 |
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100353 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108976093&doi=10.1016%2fj.obmed.2021.100353&partnerID=40&md5=bfa31843d67d60cf7f528e73f28417a9 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional (PKGR) Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Fudla, H., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Mudjihartini, N., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Khusun, H., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional (PKGR) Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Obesity is a consequence of the metabolic morbidities caused by overconsumption and lack of physical activity. Etiologically, obesity should be preventable, but reviews show that no country has yet been successful in reducing obesity, even though many efforts have been taken around the globe. This study aimed to assess effects of two non-consecutive days fasting per week on energy intake and body mass index (BMI) among obese male students aged 18–25 years at Universitas Indonesia. The collected data including demographic data, anthropometric, socio-economic status, and self-perception of obesity were used as additional information about obesity incidence as the descriptive data. A randomized controlled trial study was conducted on 40 obese male students. Their habitual intake six months before the study was measured through a semi-quantitative food frequency questionnaire. The BMI was measured using a bioelectrical impedance analysis (BIA). Intervention group did two non-consecutive days fasting per week, and recorded their fasting intake by food record diary; while control group did their habitual eating as before, and being recorded by three days 24-h recall. After a four-week intervention, the intervention group saw a significant reduction (P < 0.005) in energy intake and BMI. IF that properly followed the 5:2 protocol reduced energy intake and BMI among obese male students aged 18–25 at Universitas Indonesia in a four-week intervention. © 2021 Elsevier Ltd |
Calorie restriction; Diet; Intermittent fasting; Obesity; Weight reduction |
adult; anthropometry; Article; attitude to health; body mass; caloric intake; clinical article; controlled study; demography; food frequency questionnaire; human; impedance spectroscopy; incidence; Indonesia; intermittent fasting; male; obesity; randomized controlled trial; self concept; social status; student; therapy effect; treatment duration |
Elsevier Ltd |
24518476 |
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Article |
Q3 |
256 |
16455 |
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260 |
Saharman Y.R., Karuniawati A., Sedono R., Aditianingsih D., Qi H., Verbrugh H.A., Severin J.A. |
55980934300;54886816200;56660590500;56312263600;57200516838;7103296623;8700385500; |
Multimodal intervention to reduce acquisition of carbapenem-non-susceptible Gram-negative bacteria in intensive care units in the National Referral Hospital of Indonesia: An interrupted time series study |
2021 |
Journal of Critical Care |
64 |
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237 |
244 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107783916&doi=10.1016%2fj.jcrc.2021.04.016&partnerID=40&md5=5958a3646b6b7e60f517ca3456c7f72a |
Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
Saharman, Y.R., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sedono, R., Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Aditianingsih, D., Critical Care Division, Department of Anesthesia and Intensive Care, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Qi, H., Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Verbrugh, H.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Severin, J.A., Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands |
Purpose: To evaluate a low-cost multimodal intervention on the acquisition of carbapenem-non-susceptible Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa by patients in low-resource intensive care units. Materials and methods: We performed a quasi-experimental study in a referral hospital in Jakarta, Indonesia: pre-intervention phase 1 (2013–2014), intervention phase 2 (2014–2015) and post-intervention phase 3 (2015–2016). The intervention was hand hygiene promotion and environmental cleaning and disinfection combined with patient disinfection and cohorting. The primary outcome was acquisition of resistant bacteria per 100 patient-days at risk, which was assessed by active microbiological surveillance and analysed with a multilevel Poisson segmented regression model. Results: In phase 1 (387 patients), the acquisition rate was 4.3/100 days for carbapenem-non-susceptible A. baumannii versus 1.1/100 days for both K. pneumoniae and P. aeruginosa. There was a significant step change from phase 1 to phase 3 (361 patients) in the acquisition of carbapenem-non-susceptible strains, the incidence rate ratio (IRR) was 0.343 (99%CI: 0.164–0.717). This significant change was mainly due to reduced acquisitions of resistant A. baumannii (IRR 0.4, 99%CI: 0.181–1.061). Negative confounding was observed. Conclusion: A multimodal intervention to prevent acquisition of resistant pathogens is feasible and may be effective in ICUs in lower-middle income countries. © 2021 The Authors |
Acinetobacter baumannii-calcoaceticus complex; Acquisition rate; Carbapenem-non-susceptible; ICU; Indonesia; Klebsiella pneumoniae; Multimodal interventions; Pseudomonas aeruginosa |
carbapenem; antiinfective agent; carbapenem derivative; Acinetobacter baumannii; Acinetobacter calcoaceticus-baumannii complex; adult; aged; antibiotic sensitivity; Article; artificial ventilation; bacterium isolation; cleaning; controlled study; disease surveillance; disinfection; emergency ward; female; human; hygiene; incidence; infection control; information processing; intensive care unit; Klebsiella pneumoniae; length of stay; major clinical study; male; multidrug resistance; outcome assessment; phase 1 clinical trial; phase 2 clinical trial; phase 3 clinical trial; Pseudomonas aeruginosa; quasi experimental study; remission; Sequential Organ Failure Assessment Score; systemic inflammatory response syndrome; time series analysis; cross infection; Gram negative bacterium; hospital; In |
W.B. Saunders |
08839441 |
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34044188 |
Article |
Q1 |
1149 |
3541 |
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262 |
Uchihara Y., Permata T.B.M., Sato H., Shibata A. |
57221723636;57197808751;55697961900;8323572900; |
Modulation of immune responses by DNA damage signaling |
2021 |
DNA Repair |
104 |
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103135 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106368761&doi=10.1016%2fj.dnarep.2021.103135&partnerID=40&md5=6d7c9e9634795d347738b7c970442465 |
Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Gunma University, Gunma, Japan |
Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan |
An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses. © 2021 Elsevier B.V. |
Cancer therapy; DNA damage signaling; Immune crosstalk; Immune-associated disease; Inflammation |
nucleic acid; DNA; Article; cancer immunotherapy; DNA damage response; down regulation; human; immune response; immunomodulation; immunopathology; immunoregulation; inflammation; priority journal; signal transduction; animal; DNA damage; DNA repair; immunity; immunology; metabolism; neoplasm; signal transduction; Animals; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Immunity; Inflammation; Neoplasms; Signal Transduction |
Elsevier B.V. |
15687864 |
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34029876 |
Article |
Q1 |
2359 |
1004 |
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271 |
Yonas E., Alwi I., Pranata R., Huang I., Lim M.A., Gutierrez E.J., Yamin M., Siswanto B.B., Virani S.S. |
57201987097;15055173800;57201973901;57208576645;57216039756;57200435964;23475706300;14422648800;6701757915; |
Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review |
2021 |
American Journal of Emergency Medicine |
46 |
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204 |
211 |
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43 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090893264&doi=10.1016%2fj.ajem.2020.07.009&partnerID=40&md5=08c8139ca7f811f915c445cf5c2e3f1c |
Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Gutierrez, E.J., Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Yamin, M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Virani, S.S., Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States |
Background: Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease. Purpose: In this systematic review and meta-analysis, we attempted to investigate the association between heart failure (HF) and poor outcome in patients with COVID-19. Methods: We performed a systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and medRxiv with the search terms, “Heart failure” and “COVID-19”. The outcome of interest was mortality and poor prognosis (defined by incidence of severe COVID-19 infection, admission to ICU, and use of ventilator) in patients with preexisting heart failure with coronavirus disease. Results: We identified 204 potential articles from our search, and 22 duplicates were removed. After screening of the titles and abstracts of the remaining 182 articles we identified 92 potentially relevant articles. We excluded 74 studies due to the following reasons: four studies were systematic reviews, two studies were meta-analyses, three articles were literature reviews, and 65 articles did not report on the outcome of interest. Finally, we included the remaining 18 studies in our qualitative synthesis and meta-analysis. There were 21,640 patients from 18 studies. HF was associated with hospitalization in COVID19 HR was 2.37 [1.48, 3.79; p < 0.001], high heterogeneity [I2, 82%; p < 0.001]. HF was associated with a poor outcome demonstrated by an OR of 2.86 [2.07; 3.95; p < 0.001] high heterogeneity [I2, 80%; p < 0.001]. Patient with preexisting HF was associated with higher mortality OR of 3.46 [2.52, 4.75; p < 0.001] moderately high heterogeneity [I2, 77%; p < 0.001]. Conclusion: Patients with heart failure are at increased risk for hospitalization, poor outcome, and death from COVID-19. A significant difference in mortality between patients with and without heart failure was observed, patients with heart failure having a higher mortality. © 2020 Elsevier Inc. |
Coronavirus disease 2019; Heart failure; Poor outcomes |
apnea hypopnea index; Article; artificial ventilation; coronavirus disease 2019; heart failure; hospitalization; human; incidence; meta analysis; mortality; outcome assessment; prevalence; prognosis; questionnaire; risk factor; systematic review; comorbidity; global health; heart failure; pandemic; procedures; risk assessment; survival rate; Comorbidity; COVID-19; Global Health; Heart Failure; Humans; Pandemics; Risk Assessment; Risk Factors; SARS-CoV-2; Survival Rate |
W.B. Saunders |
07356757 |
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33071085 |
Article |
Q1 |
725 |
6828 |
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273 |
Wibowo H., Harbuwono D.S., Tahapary D.L., Kartika R., Pradipta S., Larasati R.A. |
57217690943;36056341600;55944492500;57216548032;57212562643;57212549714; |
Impact of Sodium Butyrate Treatment in LPS-Stimulated Peripheral Blood Mononuclear Cells of Poorly Controlled Type 2 DM |
2021 |
Frontiers in Endocrinology |
12 |
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652942 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112435096&doi=10.3389%2ffendo.2021.652942&partnerID=40&md5=351393601155dbe575078ee467f93e21 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biomedicines, Faculty of Medicine, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia |
Wibowo, H., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harbuwono, D.S., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tahapary, D.L., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kartika, R., Division of Metabolic Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pradipta, S., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Larasati, R.A., Department of Biomedicines, Faculty of Medicine, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia |
Type 2 diabetes mellitus (T2DM) is associated with chronic low-grade inflammation, which is marked by the dysregulation of innate and adaptive immune responses. Therefore, reducing inflammation, possibly through an immunoregulatory agent, may play a role in T2DM treatment. Butyrate is the most potent short-chain fatty acid (SCFA), and it exerts anti-inflammatory properties by inhibiting histone deacetylase activity. As an immunoregulatory agent, sodium butyrate can inhibit nuclear factor kB (NF-kB) activation and reduce the production of pro-inflammatory cytokines in immune cells. The aim of the study was to measure the level of plasma butyrate in poorly controlled T2DM and normoglycemic participants and to compare the response of peripheral blood mononuclear cells (PBMCs) to sodium butyrate treatment between the groups by measuring production of the following cytokines: tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-13, and IL-10. The in vitro study examined the PBMCs of 15 participants with poorly controlled T2DM and 15 normoglycemic participants. PBMCs were cultured with the following stimulations for two days at a temperature of 37°C and 5% CO2: 100 ng/mL lipopolysaccharide (LPS), 1 mM sodium butyrate, or a combination of 100 ng/mL LPS and 1 mM sodium butyrate. Plasma butyrate was measured using gas chromatography-mass spectrometry, and cytokines from culture supernatant were analyzed using magnetic beads multiplex assay. Plasma butyrate levels in participants with poorly controlled T2DM did not significantly differ from those in normoglycemic participants (p = 0.105). Compared to treatment with an LPS-stimulated PBMC culture, treatment with 1 mM sodium butyrate reduced the levels of TNF-α (p < 0.039) and IFN-γ (p < 0.038) in normoglycemic participants. The same general trend was seen in PBMC from participants with poorly controlled T2DM, but higher variability appeared to preclude statistical significance. These data suggest that butyrate may modulate inflammatory cytokine production in human PBMCs, but more research is needed to determine if butyrate is anti-inflammatory in poorly controlled T2DM. © Copyright © 2021 Wibowo, Harbuwono, Tahapary, Kartika, Pradipta and Larasati. |
butyrate; inflammatory response; lipopolysaccharide (LPS); peripheral blood mononuclear cells; poorly controlled type 2 diabetes mellitus |
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Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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