Per Artikel

Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Art No	Page Start	Page End	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
Display # Page 8 of 93 Start Prev 3 4 5 6 7 8 9 10 11 12 Next End
(10)
No records
135	Pujianto D., Permatasari S.	8745734300;57408686700;	Mouse CD52 is predominantly expressed in the cauda epididymis, regulated by androgen and lumicrine factors	2021	Journal of Human Reproductive Sciences	14	4		350	355	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122693572&doi=10.4103%2fjhrs.jhrs_29_21&partnerID=40&md5=442cc066428b3f1038737d1f1d81f1cc	Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Medicine, Universitas Palangka Raya, Indonesia	Pujianto, D., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, 10430, Indonesia; Permatasari, S., Department of Biology, Faculty of Medicine, Universitas Palangka Raya, Indonesia	Background: Sperm maturation takes place through contact between sperm and proteins produced in the epididymal lumen. CD52 had been characterised in the sperm; however, the expression and its regulation in the epididymis are mostly unknown. Aim: This study aimed to analyse the expression and regulation of CD52 in the mouse epididymis. Setting and Design: Experimental design was used in this study. Materials and Methods: Epididymis tissues from mice strain Deutch Democratic Yokohama were used as sources of total RNA. Bioinformatic tool was used to predict signal peptides. Quantitative real-Time reverse transcription-polymerase chain reaction was used to analyse tissue distribution, androgen, testicular factors dependency and postnatal development. Statistical Analysis: One-way analysis of variance was used to analyse differences between treatment and control untreated group. P < 0.05 was determined as a significant difference. Results: CD52 amino acid sequence contains a signal peptide, indicating it is a secretory protein. CD52 exhibited region-specific expression in the epididymis, with the highest level being in the cauda. CD52 expression was regulated by androgen indicated by a significant downregulation at day 1 and day 3 following a castration (P < 0.05). Dependency on androgen was confirmed by injection of exogenous testosterone which prevented downregulation by 50%. Moreover, lumicrine factors also influenced CD52 expression indicated by ligation of efferent duct which also reduced expression at day 1 to day 5 following the ligation (P < 0.05). CD52 expression was developmentally regulated. This was shown by increase in the level of expression starting at day 15 postnatally. Conclusion: CD52 shows characteristics of genes involved in sperm maturation in the epididymis. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.	Androgen; CD52; Epididymis; Lumicrine; Sperm maturation	androgen; bromethol; CD52 antigen; hormone; lumicrine; RNA; signal peptide; testosterone; unclassified drug; amino acid sequence; androgen therapy; animal experiment; animal tissue; antigen expression; Article; castration; cauda epididymis; controlled study; down regulation; epididymis; male; mouse; nonhuman; postnatal development; quantitative analysis; real time reverse transcription polymerase chain reaction; spermatozoon maturation; tissue distribution	Wolters Kluwer Medknow Publications	09741208	Article	Q3	484	10359	View
136	Daulay R.S., Saragih R.A.C., Daulay R.M., Ganie R.A., Tann G., Supriyatno B.	57201677329;57204321772;6504644320;57193788722;57213061716;37068046400;	Role of interferon-gamma +874 a/t single-nucleotide polymorphism and tuberculosis susceptibility of pediatric population in north sumatera, indonesia	2021	Open Access Macedonian Journal of Medical Sciences	9			1057	1060	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121721756&doi=10.3889%2foamjms.2021.7441&partnerID=40&md5=490f692392638585ec48409e7140509b	Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Daulay, R.S., Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Saragih, R.A.C., Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Daulay, R.M., Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Ganie, R.A., Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Tann, G., Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Supriyatno, B., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	BACKGROUND: Tuberculosis (TB) remains to be a leading cause of morbidity and mortality worldwide. The immune defense against Mycobacterium tuberculosis is complicated. Interferon-gamma (IFN-γ) is the main cytokine involved in the immune response of TB. To date, the role of +874 A/T single-nucleotide polymorphism (SNP) and TB disease susceptibility continues to be controversial. AIM: The aim of this study was to investigate the role of +874 A/T SNP and TB disease susceptibility of pediatric population in North Sumatera, Indonesia. METHODS: A case–control study was conducted in Medan and Batubara, North Sumatera, Indonesia, from January to December 2016. A total of 51 children with TB and 51 healthy controls were enrolled in this study. Subjects were 2 months–14 years old age children diagnosed with TB and written informed consent from the parents or the caregivers to participate. Subjects were withdrawn from the study when immunodeficiency condition was found or suffered from other infection disease. DNA samples were obtained from all of the subjects. +874 A/T SNP was identified by performing the amplification refractory mutational system-polymerase chain reaction method. IFN-γ levels were measured using human enzyme-linked immunosorbent assay. Data analysis was performed using Chi-square and Mann–Whitney test. P < 0.05 was considered statistically significant. RESULTS: The result of this study reveals that the presence of AA, AT, and TT genotype in TB patients was 31 (60.8%), 20 (39.2%), and 0 (0%), respectively (p = 0.023). Significant decreased production of IFN-γ levels (p = 0.042) was found in TB patients 9.41 (1.10–28.06) pg/ml. CONCLUSION: Our study demonstrated significant evidence of the role of +874 A/T SNP and TB disease susceptibility of pediatric population in North Sumatera, Indonesia, predominantly AA genotype. Significant decreased production of IFN-γ reported among pediatric TB. © 2021 Rini Savitri Daulay, Rina Amalia C. Saragih, Ridwan Muchtar Daulay, Ratna Akbari Ganie, Gino Tann, Bambang Supriyatno.	+874 A/T; Indonesia; Interferon-gamma; Pediatric; Single-nucleotide polymorphism; Tuberculosis	gamma interferon; adolescent; amplification refractory mutation system polymerase chain reaction; Article; case control study; child; controlled study; cytokine production; disease predisposition; DNA isolation; enzyme linked immunosorbent assay; female; fine needle aspiration biopsy; gene frequency; genotype; human; immune deficiency; infant; major clinical study; male; newborn; preschool child; school child; single nucleotide polymorphism; thorax radiography; tuberculin test; tuberculosis	Scientific Foundation SPIROSKI	18579655	Article	Q3	288	15252	View
137	Aditianingsih D., Hidayat J., Ginting V.M.	56312263600;57221444286;57377973500;	Comparison of bioimpedance versus pulse contour analysis for intraoperative cardiac index monitoring in patients undergoing kidney transplantation	2021	Anesthesiology and Pain Medicine	11	5	e117918			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121465922&doi=10.5812%2fAAPM.117918&partnerID=40&md5=cc44c95f4c7c6f8cc3dd0d4b279457ff	Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia	Aditianingsih, D., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hidayat, J., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ginting, V.M., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia	Background: Cardiac index (CI; cardiac output indexed to body surface area) is routinely measured during kidney transplant surgery. Bioimpedance cardiometry is a transthoracic impedance as the non-invasive alternative for hemodynamic monitoring, using semi-invasive uncalibrated pulse wave or contour (UPC) analysis. Objectives: We performed a cross-sectional observational study on 50 kidney transplant patients to compare the CI measurement agreement, concordance rate, and trending ability between bioimpedance and UPC analysis. Methods: For each patient, CI was measured by bioimpedance analysis (ICON™) and UPC analysis (EV1000™) devices at three time points: after induction, during incision, and at reperfusion. The device measurement accuracy was assessed by the bias value, limit of agreement (LoA), and percentage error (PE) using Bland-Altman analyses. Trending ability was assessed by angular bias and polar concordance through four-quadrant and polar plot analyses. Results: From each time point and pooled measurement, the correlation coefficients were 0.267, 0.327, 0.321, and 0.348. BlandAltman analyses showed mean bias values of 1.18, 1.06, 1.48, and 1.30, LoA of-1.35 to 3.72,-1.39 to 3.51,-1.07 to 4.04, and-1.17 to 3.78, and PE of 82.21, 78.50, 68.74, and 74.58%, respectively. Polar plot analyses revealed angular bias values of-10.37º,-15.01º,-18.68º, and-12.62º, with radial LoA of 89.79º, 85.86º, 83.38º, and 87.82º, respectively. The four-quadrant plot concordance rates were 70.77, 67.35, 65.90, and 69.79%. These analyses showed poor agreement, weak concordance, and low trending ability of bioimpedance cardiometry to UPC analysis. Conclusions: Bioimpedance and UPC analysis for CI measurements were not interchangeable in patients undergoing kidney transplant surgery. Cardiac index monitoring using bioimpedance cardiometry during kidney transplantation should be interpreted cautiously because it showed poor reliability due to low accuracy, precision, and trending ability for CI measurement. © 2021, Author(s).	Cardiac Output; Intraoperative Monitoring; Kidney Transplantation; Pulse Wave Analysis; Transthoracic Impedance	atracurium besilate; dobutamine; fentanyl; noradrenalin; propofol; sevoflurane; adult; aged; agitation; anesthesia induction; arterial pressure; Article; body mass; bradycardia; cardiac index; cardiopulmonary bypass; central venous pressure; chronic kidney failure; correlation coefficient; cross-sectional study; female; heart arrhythmia; heart output; heart rate; heart stroke volume; hemodynamic monitoring; human; hypertension; intraoperative monitoring; kidney transplantation; major clinical study; male; mean arterial pressure; measurement accuracy; nausea and vomiting; observational study; outcome assessment; pleura effusion; prospective cost; prospective study; pulse oximetry; pulse wave; systolic blood pressure; tachycardia; transesophageal echocardiography; uncalibrated pulse contour	Kowsar Medical Institute	22287523	Article	Q2	438	11251	View
138	Gunardi T.H., Susantono D.P., Victor A.A., Sitompul R.	57195939686;57353411000;57191055282;8312163900;	Atopobiosis and dysbiosis in ocular diseases: Is fecal microbiota transplant and probiotics a promising solution?	2021	Journal of Ophthalmic and Vision Research	16	4		631	643	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119915775&doi=10.18502%2fJOVR.V16I4.9754&partnerID=40&md5=8d0e2b295a398c85ff1c28564276103b	Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Gunardi, T.H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Susantono, D.P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Victor, A.A., Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sitompul, R., Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Purpose: To highlight the role of atopobiosis and dysbiosis in the pathomechanism of autoimmune uveitis, therefore supporting fecal microbiota transplant (FMT) and probiotics as potential targeted-treatment for uveitis. Methods: This review synthesized literatures upon the relation between gut microbiota, autoimmune uveitis, FMT, and probiotics, published from January 2001 to March 2021 and indexed in PubMed, Google Scholar, CrossRef. Results: The basis of the gut-eye axis revolves around occurrences of molecular mimicry, increase in pro-inflammatory cytokines, gut epithelial barrier disruption, and translocation of microbes to distant sites. In patients with autoimmune uveitis, an increase of gut Fusobacterium and Enterobacterium were found. With current knowledge of aforementioned mechanisms, studies modifying the gut microbiome and restoring the physiologic gut barrier has been the main focus for pathomechanism-based therapy. In mice models, FMT and probiotics targeting repopulation of gut microbiota has shown significant improvement in clinical manifestations of uveitis. Consequently, a better understanding in the homeostasis of gut microbiome along with their role in the gut-eye axis is needed to develop practical targeted treatment. Conclusion: Current preliminary studies are promising in establishing a causative gut-eye axis relationship and the possibility of conducting FMT and probiotics as targeted treatment to mitigate autoimmune uveitis, to shorten disease duration, and to prevent further complications. © 2021 GUNARDI ET AL. THIS IS AN OPEN ACCESS ARTICLE DISTRIBUTED UNDER THE CREATIVE COMMONS ATTRIBUTION LICENSE \| PUBLISHED BY KNOWLEDGE E	Atopobiosis; Autoimmune; Dysbiosis; Gut-Eye Axis; Uveitis		Knowledge E	20082010	Review	Q3	557	9058	View
139	Harzif A., Anggraeni T., Syaharutsa D., Hellyanti T.	57191493435;57192894826;57204145265;57217993236;	Hysteroscopy role for female genital tuberculosis	2021	Gynecology and Minimally Invasive Therapy	10	4		243	246	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119285063&doi=10.4103%2fGMIT.GMIT_151_20&partnerID=40&md5=2dea6cbfe3f4a65bb9bc6b632d3cc573	Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Harzif, A., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Anggraeni, T., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syaharutsa, D., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hellyanti, T., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Female genital tuberculosis affects the quality of women's lives. One of the symptoms is amenorrhea. In our country, it is still underdiagnosed due to limited resources. Hysteroscopy is known as one of the diagnostic tools for this condition. We performed hysteroscopy and endometrial biopsy in four cases. Hysteroscopy findings show various signs. Histopathological examination showed typical features of tuberculosis in some cases. We also learned that hysteroscopy could evaluate the condition of the endometrium when ongoing and after treatment is accomplished. It is useful for further explanation to the client. Hysteroscopy can be utilized as a diagnostic tool for endometrial sampling, evaluate intracavity condition after treatment, and prognostic tool for future reproductive function. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.	Amenorrhea; caseous necrosis; genital tuberculosis; hysteroscopy	tuberculostatic agent; adolescent; adult; Article; case report; caseation; chronic inflammation; clinical article; clinical feature; diagnostic value; echography; endometritis; endometrium; endometrium biopsy; female; female genital tuberculosis; granulomatous inflammation; histopathology; human; human tissue; hysteroscopy; laparotomy; primary amenorrhea; secondary amenorrhea; sister; tuberculous peritonitis; tuberculous spondylitis	Wolters Kluwer Medknow Publications	22133070	Article	Q3	441	11202	View
141	Findyartini A., Raharjanti N.W., Greviana N., Prajogi G.B., Setyorini D.	56543777300;57226872499;57197709749;57221911632;57218906783;	Development of an app-based e-portfolio in postgraduate medical education using entrustable professional activities (Epa) framework: Challenges in a resource-limited setting	2021	Asia Pacific Scholar	6	4		92	106	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119047428&doi=10.29060%2fTAPS.2021-6-4%2fOA2459&partnerID=40&md5=6cdd410ca553690d4851ccd981856007	Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Oncology Radiation, Faculty of Medicine, Universitas Indonesia, Indonesia	Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Raharjanti, N.W., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Greviana, N., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Prajogi, G.B., Department of Oncology Radiation, Faculty of Medicine, Universitas Indonesia, Indonesia; Setyorini, D., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia	Introduction: E-portfolio may facilitate the entrustment process from supervisors to residents in postgraduate medical education. The present study was aimed at identifying necessary features of an e-portfolio application and to conduct pilot study in a teaching hospital. Methods: Six programs participated. Eight interviews with education directors and six focus group discussions with residents and supervisors were completed for the needs analysis stage. The application was developed based on the thematic analysis of the needs analysis stage. The mobile-app e-portfolio pilot was conducted for four weeks and a modified version of the System Usability Scale (SUS) was distributed to participants following the pilot program. Results: Key features of the e-portfolio were identified. A total of 45 supervisors and 66 residents participated in the pilot study. The residents utilised the application according to the clinical activities and supervision level, and the information was fed to the supervisors as per the application design. Challenges during the pilot study in terms of feedback provision and residents’ workload which influence the e-portfolio use for entrustment decisions are discussed. Conclusion: Current e-portfolio features were created for supervision and are potential to facilitate the entrustment process in Entrustable Professional Activities (EPA) implementation. The pilot study highlighted challenges of the implementation which should be considered for future improvement. © 2021 TAPS. All rights reserved.	E-Portfolio; Entrustable Professional Activities; Needs Analysis; Pilot Study; Postgraduate Medical Education; Supervision		National University of Singapore, Faculty of Law	24249335	Article	#N/A	#N/A	#N/A	View
142	Teja Y., Nareswari I.	57325017200;57194336586;	Acupuncture Therapies for Addressing Post Odontectomy Neuropathy	2021	Medical Acupuncture	33	5		358	363	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118590707&doi=10.1089%2facu.2020.1472&partnerID=40&md5=28463ebc7dc0a38e9601eb0cf906c286	Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Daerah Istimewa Jakarta, Jakarta, Indonesia	Teja, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Daerah Istimewa Jakarta, Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Daerah Istimewa Jakarta, Jakarta, Indonesia	Background: Third-molar extraction is a common oral surgical procedure that can cause complications. Although rare, nerve injuries that result in permanent neuropathy can occur and include a variety of complaints such as sensory disorders, taste-sensation disorders, speech articulation disorders, etc. Acupuncture is one of several nonpharmacologic therapies that has played a role in managing neuropathic lesions and has been proven to produce good results. Case: A 44-year-old woman with postodontectomy neuropathy developed paresthesia, dysarthria, xerostomia, dysgeusia, pain in the gums and lower right jaw, a chewing disorder, and cephalgia. Her numerical rating scale (NRS) results were: lower right gum pain, 3/10; numbness of the tongue, 4/10; and headache, 1/10. A physical examination revealed dysarthria, a decreased sense of sharpness and dullness in the right mandibular nerve branches, decreased right masseter muscle contractions, and tenderness on the right GB 20 point. Electromyography revealed partial functional lesions in the postganglion at the right fifth cranial nerve. She had body acupuncture therapy at GV 20, GB 20, ST 5, ST 6, ST 7, CV 23, LI 4, HT 5, ST 36, LU 7, and KI 6; ear acupuncture at the Parotid and Shenmen points; and treatment with the Tan Balance Method. Results: After 3 consecutive sessions of acupuncture therapy, this patient's symptoms were reduced. Conclusions: Acupuncture was helpful for reducing paresthesia, dysarthria, xerostomia, dysgeusia, gum and lower right jaw pain, a chewing disorder, and cephalgia in this patient with postodontectomy neuropathy. Clinical trials are needed to support the findings in this case. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.	acupuncture; dysarthria; dysgeusia; neuropathy; odontectomy; paresthesia	paracetamol; acupuncture; adult; analgesia; Article; baihui acupoint; case report; clinical article; daying acupoint; dysarthria; dysgeusia; electromyography; female; fengchi acupoint; gingiva pain; hegu acupoint; human; hypesthesia; jaw pain; jiache acupoint; lianquan acupoint; lieque acupoint; mandibular nerve; masseter muscle; mastication; muscle contraction; neuropathy; numeric rating scale; paresthesia; parotid gland; physical examination; postoperative complication; tongli acupoint; tongue; tooth extraction; trigeminal nerve; xerostomia; xiaguan acupoint; zhaohai acupoint; zusanli acupoint	Mary Ann Liebert Inc.	19336586	Article	Q2	281	15498	View
143	Djaali W., Mihardja H., Viventius Y., Teja Y., Bunawan H.L., Setiawan M., Yunita L.	57212479564;57195721818;57223088537;57325017200;57324454000;57324269700;57324454100;	The Role of Acupuncture in Interventional Pain Management	2021	Medical Acupuncture	33	5		329	334	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118530798&doi=10.1089%2facu.2021.0004&partnerID=40&md5=7d65d90740d49223d9332a2572c084c0	Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Negeri Jakarta, East Jakarta, DKI Jakarta, Indonesia; Center for the Development and Application of Traditional Medicine of DKI Jakarta, Jakarta, Indonesia	Djaali, W., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Negeri Jakarta, East Jakarta, DKI Jakarta, Indonesia; Mihardja, H., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Center for the Development and Application of Traditional Medicine of DKI Jakarta, Jakarta, Indonesia; Viventius, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Teja, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bunawan, H.L., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, M., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yunita, L., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Objective: Interventional pain management has been recognized over the last couple of decades for treating chronic-pain syndromes. Acupuncture is a nonpharmacologic therapeutic option for pain management and may be an option for different patients with contraindications for interventional pain management. This review explores this options. Method: This limited review examines the role of acupuncture for managing head-and-neck pain and lower-back pain, according to interventional pain management. Conclusions: Acupuncture at various points, corresponding to the stellate ganglion, which is ST 10 Shuitu, and corresponding to the splanchnic nerve and the facet joint of the lumbar vertebra - which are Ex-B2 paravertebra - can be applied for pain management in the head-and-neck area and in the lower-back area. According to various research findings, acupuncture is effective and safe for reducing pain in the head and neck area, as well as in the lower back. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.	acupuncture; head-and-neck pain; interventional pain management; lower-back pain	acupuncture analgesia; headache; human; interventional pain management; intervertebral articulation; low back pain; neck pain; nerve block; neuroanatomy; paraspinal muscle; Review; shuitu acupoint; splanchnic nerve; stellate ganglion; stellate ganglion block	Mary Ann Liebert Inc.	19336586	Review	Q2	281	15498	View
145	Hansur L., Pawitan J.A.	57296411600;6508348067;	The potential of hydroxysafflor yellow a as an adjuvant in covid-19 patients with acute respiratory distress syndrome	2021	International Medical Journal	28	5		527	531	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117118067&partnerID=40&md5=caa56a92d25ef57cc5e5c3533887adf1	Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Makassar, Makassar, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Hansur, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Muhammadiyah Makassar, Makassar, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Objective: To discuss the potential and molecular mechanism of Carthamus tincorius derived hydroxysafflor yellow A (HSYA) as an alternative herbal adjuvant that may regulate various signaling pathways that might be related to the regulatory effects in COVID-19 patients with ALI and ARDS. Methods: We search Web of Science, PubMed, and Scopus using keywords: Carthamus tinctorius, adjuvant, cytokine storm, COVID-19, SARS-Cov-2, acute lung injury (ALI), and Acute Respiratory Distress Syndrome (ARDS), on 11 September 2020, and 18 December 2020. Results and Discussions: In COVID-19 patients, SARS-CoV-2 replication might be associated with hyper induction of pro-in-flammatory cytokine, which is known as a cytokine storm, and may cause acute lung injury (ALI) that leads to Acute Respiratory Distress Syndrome (ARDS). Carthamus tincorius derived HSYA were used in many studies, in vivo in animal models or in vitro in cell lines and showed inhibition of multiple inflammatory pathways that were involved in ALI and ARDS, which might occur in covid-19 patients. HSYA showed pleiotropic effects in regulating cytokine levels. It regulated TNF-α, IL-1β, IL-6, IFN-β, and showed protective effect by blocking TLR4, MyD88, TRIF, IRF3, NF-κB to avoid cytokine storm and prevent tissue damage. HSYA was showed to reduce oxidative stress-mediated damage, and down-regulate inflammatory cytokines. Further, it was relatively safe when studied as an adjuvant in HIV and cancer patients. Conclusion: We supposed that HSYA could be used as an alternative adjuvant in COVID-19 patients with ARDS. However, clinical trials are needed to prove its efficacy in COVID-19 patients with ARDS. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation.	Carthamus tinctorius; COVID-19; Cytokine storm; HSYA; SARS-Cov-2	adjuvant; curcumin; hydroxysafflor yellow a; interleukin 1beta; interleukin 6; interleukin 8; myeloid differentiation factor 88; natural product; pathogen associated molecular pattern; toll like receptor 4; tumor necrosis factor; unclassified drug; acute lung injury; adult respiratory distress syndrome; antiinflammatory activity; apoptosis; Article; binding affinity; brain ischemia; cancer patient; coronavirus disease 2019; cytokine production; cytokine storm; down regulation; dyspnea; endothelial dysfunction; endothelium cell; enzyme activity; human; Human immunodeficiency virus; immune response; inflammation; lung edema; nonhuman; pleiotropy; protein expression; protein function; reperfusion injury; respiratory failure; Severe acute respiratory syndrome coronavirus 2; signal transduction	Japan International Cultural Exchange Foundation	13412051	Article	Q4	183	20490	View
146	Dwijayanti A., Pawitan J.A.	55743787900;6508348067;	Mesenchymal stem cell aging, their environment and methods to restore their quality	2021	International Medical Journal	28	5		520	523	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117117062&partnerID=40&md5=e4cc00f4efb942f9321160eff1b790a8	Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Dwijayanti, A., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Objective: This article aims to explore the aging of mesenchymal stem cells (MSCs) during cell expansion and available methods to restore their quality. Materials and methods: we searched articles in PubMed/Medline and our library to collect relevant publications of MSC aging, their microenvironment (niche), and various approaches to prevent MSC aging. Results and Discussion: MSC expansion during culture may cause cell aging, which is reflected by change in growth, geno-type, and phenotype that can be seen in morphology and function. There are various approaches that can be used to prevent MSC aging. Approaches to prevent MSC aging in culture can be done by various methods, including by determining donor characteristics, genetic engineering approaches, regulating stem cells microenvironment in vitro, and in vitro physical modification Conclusion: Prevention of MSC aging during culture can be done by selection of MSC sources, genetic modification, and microenvironment and physical adjustments. ©2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation.	Aging; Cell culture; Mesenchymal stem cells; Micro environment; Propagation	adult; article; cell aging; cell culture; DNA modification; genetic engineering; human; human cell; Medline; mesenchymal stem cell; microenvironment; phenotype; stem cell expansion	Japan International Cultural Exchange Foundation	13412051	Article	Q4	183	20490	View

Publikasi Scopus 926 artikel (Per 14 Maret 2022)