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Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Art No	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Pubmed Id	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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177	Karina K., Ekaputri K., Albert Biben J., Rosadi I., Rosliana I., Sobariah S., Sulaeha A.D., Andrew H., Afini I., Widyastuti T., Jusryanti J., Prestiani S.I., Donna I.M., Mutiara M.S., Habibi H.	57212146678;57285088000;57284643500;57204720098;57186671400;57203547382;57226286645;57226282534;57211068324;57211074403;57284643600;57283770100;57284210300;57284210400;57222314524;	Evaluation of plasma pdgf and vegf levels after systemic administration of activated autologous platelet-rich plasma	2021	Biomedicine (India)	41			409	412		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116318936&doi=10.51248%2f.v41i2.1047&partnerID=40&md5=b63a888f3eb59bb12b87fdd1bfa4f091	Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, 752424, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta Pusat, 10430, Indonesia	Karina, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia, Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia, Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia, Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Ekaputri, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Albert Biben, J., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Rosadi, I., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia, Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, 752424, Indonesia; Rosliana, I., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Sobariah, S., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Sulaeha, A.D., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Andrew, H., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta Pusat, 10430, Indonesia; Afini, I., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Widyastuti, T., Hayandra Lab, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Jusryanti, J., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Prestiani, S.I., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Donna, I.M., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Mutiara, M.S., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia; Habibi, H., Klinik Hayandra, Yayasan Hayandra Peduli, Jl. Kramat VI No. 11, Jakarta Pusat, 10430, Indonesia	Introduction and Aim: Activated autologous platelet-rich plasma (aaPRP) is becoming a popular therapy to accelerate healing in the field of plastic surgery. Platelets, which are abundant in aaPRP, can release many growth factors including platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). This study aims to examine the plasma levels of PDGF and VEGF in healthy subjects after intravenous administration of aaPRP. Materials and Methods: Nine healthy patients with no prior history of metabolic disease were divided into two groups (control and experiment group). The treatment group which consists of six patients received intravenous aaPRP treatment. The preparation of aaPRP starts with the collection of 24 mL of whole blood in sodium citrate tubes followed a two-step centrifugation procedure and subsequent chemical activation. aaPRP was then administered intravenously to patients. Meanwhile, the control group received no intervention. Venous blood samples were taken before and one week after the treatment and the plasma PDGF and VEGF levels were determined by enzyme-linked immunosorbent assay (ELISA). Results: The treatment group showed statistically significant increase in VEGF after 7 days compared to before aaPRP administration. However, the change in PDGF levels of the treatment group was unnotable. Conclusion: The present findings indicate that intravenous administrations of activated aaPRP may increase plasma VEGF level up to 1 week after aaPRP administration. © 2021, Indian Association of Biomedical Scientists. All rights reserved.	Activated autologous platelet-rich plasma (aaPRP); Platelet derived growth factor (PDGF); Vascular endothelial growth factor (VEGF)	activated autologous platelet rich plasma; citrate sodium; platelet derived growth factor; thrombocyte concentrate; unclassified drug; vasculotropin; adult; Article; blood autotransfusion; blood chemistry; blood sampling; case control study; centrifugation; cohort analysis; controlled study; enzyme linked immunosorbent assay; female; human; human cell; male; metabolic disorder; middle aged; observational study; prospective study; protein blood level; thrombocyte rich plasma; venous blood	Indian Association of Biomedical Scientists	09702067		Article	Q4	106	29384	View
441	Sukmawati D., Junaidi H., Syaidah R.	55615650900;57202926303;55418885900;	Human platelet-rich plasma as a biological stimulant for proliferation and differentiation of mesenchymal stem cells	2021	Biomedicine (India)	41	2		168	173		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117427828&doi=10.51248%2f.v41i2.777&partnerID=40&md5=08fabc44956a1de6990d42feb38813ba	Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia	Sukmawati, D., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Junaidi, H., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Syaidah, R., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia	Platelet is one of the cells within the blood that have potential in regenerative therapy. Recently platelet-related products got special attention due to the abundance of growth factors and easy availability and processing. With the robust in cell-based therapy, platelet-rich plasma (PRP) has been intensively studied for its potential to substitute the fetal bovine serum (FBS) as the supplement in cell culture. Our study aimed to investigate the use of human PRP in mesenchymal stem cells (MSC) culture and its related effect on stem cell biology. We searched in vitro studies that used human PRP as a supplementing factor on human MSCs culture. From the initial 172 studies, 14 studies fulfilled the selection criteria and were analysed. The results showed that the sources of MSCs were varied, including adipose tissue, bone marrow, and dental tissue. The PRP concentration showing the best effects was ranged from 10 to 20%. In addition, most of the studies demonstrated the superiority of PRP to FBS in promoting the proliferation and differentiation of MSCs in vitro. Therefore, PRP could be an alternative to FBS in supporting a xeno-free culture system. Studies are needed to reveal the mechanism of PRP in maintaining the physiology of MSCs. © 2021, Indian Association of Biomedical Scientists. All rights reserved.	Cell culture; Differentiation; Mesenchymal stem cells; Platelet-rich plasma; Proliferation; Xeno-free	adipose tissue; Article; bone marrow; cell differentiation; cell proliferation; controlled study; human; human cell; in vitro study; mesenchymal stem cell; thrombocyte rich plasma; tooth tissue; xeno-free culture	Indian Association of Biomedical Scientists	09702067		Article	Q4	106	29384	View
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484	Sumantri S., Rengganis I., Laksmi P.W., Hidayat R., Koesnoe S., Shatri H.	6504606748;8449988000;8448343700;37067327300;26028015000;28767986500;	The impact of low muscle function on health-related quality of life in Indonesian women with systemic lupus erythematosus	2021	Lupus	30	4		680	686		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099752699&doi=10.1177%2f0961203320988595&partnerID=40&md5=98c96d7b7268512fcf94e7eabca204b8	Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Geriatric Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rheumatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Psychosomatic Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia	Sumantri, S., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Rengganis, I., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Laksmi, P.W., Geriatric Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hidayat, R., Rheumatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Koesnoe, S., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Shatri, H., Psychosomatic Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia	Objective: There was no study aimed at evaluating the effect of muscle function on SLE patients' quality of life using the Sarcopenia Quality of Life (SarQoL) questionnaire. Methods: This cross-sectional study recruited 61 women with SLE consecutively, muscle function was measured with Jamar handheld-dynamometer and 6-meter walk test, HRQoL was measured with Sarcopenia Quality of Life (SarQoL) questionnaire. The cut-off point for low muscle strength (<18 kg) and low gait speed (<1.0 m/s) was according to the Asian Working Group on Sarcopenia 2019 criteria. Statistical analysis was conducted with a t-test for mean difference, and linear regression was used to adjust confounders (age, protein intake, physical exercise, and disease activity). Results: The subjects' mean muscle strength was 19.54 kg (6.94), and 44.3% (n = 27) was found to have low muscle strength. The subjects' mean gait speed was 0.77 m/s (0.20), and 90.3% (n = 55) was found to have low gait speed. The difference of total SarQoL score in subjects with normal and low muscle strength was found to be significant; 74.86 (9.48) vs. 65.49 (15.51) (p = 0.009), and still statistically significant after adjustments with age, protein intake, physical exercise level, and disease activity [B 0.56; 95% CI 0.08–1.03; p = 0.022]. The difference of total SarQoL score in subjects with normal and low physical performance was found to be not significant, 70.67 (11.08) vs. 70.72 (13.56) (p = 0.993). Conclusion: There was a significant difference in SarQoL's total score in normal compared with low muscle strength groups of Indonesian women with SLE. © The Author(s) 2021.	health-related quality of life; Muscle function; muscle strength; physical performance; SarQoL; systemic lupus erythematosus	corticosteroid; creatine kinase; prednisone; vitamin D; protein; adult; age; Article; corticosteroid therapy; creatine kinase blood level; cross-sectional study; disease activity; exercise; female; human; Indonesian; kidney function; low drug dose; lupus erythematosus nephritis; major clinical study; muscle function; muscle mass; muscle strength; pain severity; physical activity; physical performance; priority journal; protein intake; quality of life; quality of life assessment; Sarcopenia Quality of Life Questionnaire; six minute walk test; SLEDAI; systemic lupus erythematosus; vitamin blood level; walking speed; comparative study; epidemiology; immunology; Indonesia; muscle; pathophysiology; physiology; procedures; psychology; quality of life; questionnaire; sarcopenia; severity of illne	SAGE Publications Ltd	09612033	33470149	Article	Q2	1069	3961	View
1071(1)
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57	Diptyanusa A., Sari I.P.	57205340891;57197543698;	Treatment of human intestinal cryptosporidiosis: A review of published clinical trials	2021	International Journal for Parasitology: Drugs and Drug Resistance	17			128	138		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115755098&doi=10.1016%2fj.ijpddr.2021.09.001&partnerID=40&md5=e7d5494025a277d99586bf5f73027625	Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia; Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia	Diptyanusa, A., Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia, Study Program of Medical Specialist in Clinical Parasitology, Faculty of Medicine, University of Indonesia, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Indonesia	The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis can result in long-term morbidity and high illness costs. The evidence of effective treatments for cryptosporidiosis has been lacking. We reviewed the published clinical trials to bring forward the feasible therapeutic options of human cryptosporidiosis in various populations and settings according to clinical improvement and parasite clearance rates. A total of 42 studies consisting of the use of nitazoxanide, paromomycin, macrolides, somatostatin analogues, letrazuril, albendazole, rifaximin, miltefosine, clofazimine, and colostrum were included in the review. The trials were mostly conducted in small number of individuals infected with human immunodeficiency virus (HIV), and there is inadequate data of controlled trials to suggest the use of these treatment modalities. Nitazoxanide was reported to be highly efficacious only in immunocompetent hosts and was found to be superior to paromomycin in the same group of patients. Macrolides showed no effective results in both clinical and parasitological improvement. Human bovine colostrum should possibly be administered as one of complementary therapeutic modalities along with other antimicrobials to reach optimal parasite eradication. Other trials of therapeutic modalities were terminated due to futility. Currently, available data is intended to aid the development of strategies for improving access to treatments in different clinical settings, as well as to help guide further studies on treatments of human intestinal cryptosporidiosis. © 2021	Clearance; Clinical trial; Cryptosporidiosis; Cryptosporidium; Drug; Treatment	acetylspiramycin; albendazole; alkaline phosphatase; antiparasitic agent; azithromycin; clofazimine; erythromycin; garlicin; immunoglobulin; letrazuril; macrolide; miltefosine; nitazoxanide; octreotide; paromomycin; placebo; probiotic agent; rifaximin; roxithromycin; somatostatin derivative; spiramycin; unclassified drug; vapreotide; antiprotozoal agent; paromomycin; abdominal pain; adolescent; adult; aged; alkaline phosphatase level; alternative medicine; anorexia; antiparasitic therapy; child; cholecystitis; clinical trial (topic); colostrum; constipation; cryptosporidiosis; diarrhea; dizziness; drowsiness; drug efficacy; fatigue; fever; headache; health care access; human; Human immunodeficiency virus infection; hypertransaminasemia; infant; injection site pain; intestine obstruction; k	Elsevier Ltd	22113207	34562754	Review	Q1	1071	3953	View
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521	Gunardi E.R., Putri R.A., Pasidri Y.	57192910998;57226166006;57226151144;	A prospective study of effectivity, expulsion, and acceptability of post-placental iud cu t380a insertion using clamp in a tertiary hospital	2021	Journal of SAFOG	13	2		92	96		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110568167&doi=10.5005%2fjp-journals-10006-1884&partnerID=40&md5=fce9faf05542751a7f70c62d508122a7	Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Gunardi, E.R., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.A., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Aim: Intrauterine device (IUD) has a high effectivity of long-term contraception method. Post-placental IUD increases the number of contraception use and decreases the unmet need for contraception. The purposes of this study were to evaluate the effectivity, expulsion, acceptability, and side effects of post-placental IUD insertion using a clamp at Dr. Cipto Mangunkusumo National General Hospital. Materials and methods: This prospective longitudinal observational study was conducted at a tertiary teaching hospital (Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) from April 2018 to March 2019. Post-placental IUD was inserted using a clamp. We interviewed the patients at 3 months and 6 months after insertion to evaluate the outcome. A total of 94 women were included in this study. Results: The effectivity was 100%. The expulsion rate was 2.13, 3.45, and 0% at 6 weeks, 3 months, and 6 months, respectively. The total acceptability rate at 6 weeks, 3 months, and 6 months was 96.81, 93.3, and 90.8%, respectively. Most of the subjects were satisfied with the IUD contraception at 3 months and 6 months. Conclusion: Post-placental IUD insertion using a clamp had good safety, effectivity, acceptance, and satisfaction. This data could be used for family planning counseling in daily practice. Post-placentaI IUD insertion should be routinely offered to all eligible postpartum women undergoing institutional deliveries. © Jaypee Brothers Medical Publishers.	Acceptability; Effectivity; Expulsion; Insertion using a clamp; Post-placental IUD	abdominal pain; adult; Article; bleeding; cesarean section; clinical outcome; contraception; controlled study; counseling; dyspareunia; family planning; female; follow up; gestational age; health care facility; human; hysterectomy; intrauterine device expulsion; lactation; longitudinal study; major clinical study; menstrual cycle; menstruation disorder; observational study; patient satisfaction; percutaneous coronary intervention; postpartum hemorrhage; postpartum pain; pregnancy; pregnancy outcome; pulse rate; questionnaire; tablet disintegration time; tertiary care center; unwanted pregnancy; vagina bleeding; vagina discharge (disease); vaginal delivery	Jaypee Brothers Medical Publishers (P) Ltd	09748938		Article	Q4	108	29032	View
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176	Nakhaei P., Margiana R., Bokov D.O., Abdelbasset W.K., Jadidi Kouhbanani M.A., Varma R.S., Marofi F., Jarahian M., Beheshtkhoo N.	57226413840;56685900600;56845561300;57208873763;57219274421;7201793587;57199650994;16241593900;57201547070;	Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol	2021	Frontiers in Bioengineering and Biotechnology	9		705886			4	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115653337&doi=10.3389%2ffbioe.2021.705886&partnerID=40&md5=0d6cee3ed2be3a97e6c2beb3d6c668b5	School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany	Nakhaei, P., School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Jadidi Kouhbanani, M.A., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Varma, R.S., Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Marofi, F., Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany; Beheshtkhoo, N., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic	Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol. © Copyright © 2021 Nakhaei, Margiana, Bokov, Abdelbasset, Jadidi Kouhbanani, Varma, Marofi, Jarahian and Beheshtkhoo.	cholesterol; compounds; lipids; liposome; stability	Automobile manufacture; Chemical stability; Controlled drug delivery; Food products; Liposomes; Medical applications; Phospholipids; Plasma stability; Targeted drug delivery; Application parameters; Biomedical applications; Compound; Hydrophilic heads; Hydrophobic tails; Liposome structures; Multi-layered; Phospholipid membrane; Spherical structures; Stability parameters; Cholesterol	Frontiers Media S.A.	22964185		Review	Q1	1081	3891	View
1084(1)
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68	Yunihastuti E., Amelia F., Hapsari A.I., Wicaksana B., Natali V., Widhani A., Sulaiman A.S., Karjadi T.H.	57221273925;57216937074;57224070662;57216937319;57216936185;57202561455;57216938482;57219422563;	Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus	2021	Health and Quality of Life Outcomes	19	1	154				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106964144&doi=10.1186%2fs12955-021-01777-x&partnerID=40&md5=2f9401a263635d553b2c13c95a895839	Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia; HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hepatobilliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Yunihastuti, E., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Amelia, F., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hapsari, A.I., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Wicaksana, B., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Natali, V., HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Widhani, A., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Sulaiman, A.S., Hepatobilliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karjadi, T.H., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo Hospital, Diponegoro 71, Jakarta, Indonesia, HIV Integrated Services, Ciptomangunkusumo Hospital, Jakarta, Indonesia	Background: We conducted a real-life study of health-related quality of life (HRQoL) transformation before and 12 weeks after sofosbuvir and daclatasvir therapy in HCV/HIV co-infected patients. Factors related to the significant changes of each HRQoL domain/item were also evaluated. Methods: A prospective study was performed in the HIV integrated clinic at Cipto Mangunkusumo Hospital, Jakarta. HCV/HIV co-infected patients who started sofosbuvir and daclatasvir from government free DAA program in 2017–2019. WHOQoL-HIV BREF and RAND SF-36 questionnaires were recorded at baseline and post-treatment week 12. Results: 145 patients with mean age of 37.8 years (SD = 4.2) were included in the analysis. Most of patients were male (89%), previous IVDU (89%), active smoker (50.4%) and non-cirrhosis (80%). SVR12 was achieved in 95.5% of patients. Sofosbuvir and daclatasvir treatments showed positive impacts on 2 domains and 2 other items of WHOQoL-HIV BREF and 2 domains and 1 item of SF-36. Predicting factors of significant increase in each domain/item were: male and normal body mass index (BMI) for level of independence (RR 4.01,95% CI 1.09–14.74 and 4.80,95% CI 1.79–12.81); higher HCV-RNA for overall perception of QoL (RR 0.42,95% CI 0.18–0.94); non-smoking status for overall perception of health (RR 0.32,95% CI 0.15–0.66); male and fibrosis stage 0–1 for general health (RR 6.21,95% CI 1.69–22.88 and 2.86,95% CI 1.16–7.00); and the use of NNRTI-based ART (RR 5.23, 95% CI 1.16–23.65). Spiritual/personal belief decline was predicted by non-smoking status (RR 0.46, 95% CI 0.23–0.95). Treatment success was not associated with any changes of HR-QoL domain/item. Conclusions: HCV/HIV co-infected patients were successfully treated with sofosbuvir and daclatasvir and experienced improvement of HRQoL 12 weeks after treatment completion. © 2021, The Author(s).	Daclastavir; HCV; Health-related quality of life; Hepatitis C; HIV; Sofosbuvir	daclatasvir; efavirenz; nevirapine; nonnucleoside reverse transcriptase inhibitor; sofosbuvir; antivirus agent; carbamic acid derivative; imidazole derivative; pyrrolidine derivative; sofosbuvir; valine; adult; age; antiretroviral therapy; Article; attitude to health; body mass; cohort analysis; coinfection; controlled study; current smoker; drug effect; drug use; female; general condition improvement; government regulation; health program; hepatitis C; Hepatitis C virus; human; Human immunodeficiency virus; Human immunodeficiency virus infection; liver cirrhosis; major clinical study; male; non-smoker; observational study; patient care; prediction; prospective study; quality of life; Short Form 36; sustained virologic response; treatment duration; treatment outcome; chronic hepatitis C; c	BioMed Central Ltd	14777525	34039353	Article	Q1	1084	3877	View
109(1)
No records
590	Ngoo K.S., Fadzli A.N., Amponin M.O.C.S.E., Cho S.Y., Chuang Y.-C., Horiguchi A., Karthikeyan V.S., Morshed M.S., Situmorang G.R., Tan T.C., Teoh J.Y.-C., Thaidumrong T., Ong T.-A.	24577210000;56690508000;57221558858;55686246500;16416810000;21634678200;55320137500;57200423093;57190001213;57221554527;55337855700;44062024500;7102866871;	COVID-19 pandemic impact on urology residencies in Asia - An observational study	2021	Surgical Practice	25	1		10	15	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099476598&doi=10.1111%2f1744-1633.12474&partnerID=40&md5=2f2654abe61580ca20505968f145337d	Department of Surgery, Hospital Angkatan Tentera Tuanku Mizan, Kuala Lumpur, Malaysia; Urology Unit, Department of Surgery, University of Malaya Medical Center, Kuala Lumpur, Malaysia; Department of Surgery, Our Lady of Lourdes Hospital, Manila, Philippines; Department of Urology, Seoul National University Hospital, Seoul, South Korea; Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Urology, National Defense Medical College, Saitama, Japan; Men's Health and Urology, Sri Narayani Hospital and Research Centre, Vellore, India; Department of Urology, Dhaka Medical College Hospital, Dhaka, Bangladesh; Department of Urology, Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Urology C Department, Binh Dan Hospital, Ho Chi Minh City, Viet Nam; Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand	Ngoo, K.S., Department of Surgery, Hospital Angkatan Tentera Tuanku Mizan, Kuala Lumpur, Malaysia; Fadzli, A.N., Urology Unit, Department of Surgery, University of Malaya Medical Center, Kuala Lumpur, Malaysia; Amponin, M.O.C.S.E., Department of Surgery, Our Lady of Lourdes Hospital, Manila, Philippines; Cho, S.Y., Department of Urology, Seoul National University Hospital, Seoul, South Korea; Chuang, Y.-C., Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Horiguchi, A., Department of Urology, National Defense Medical College, Saitama, Japan; Karthikeyan, V.S., Men's Health and Urology, Sri Narayani Hospital and Research Centre, Vellore, India; Morshed, M.S., Department of Urology, Dhaka Medical College Hospital, Dhaka, Bangladesh; Situmorang, G.R., Department of Urology, Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tan, T.C., Urology C Department, Binh Dan Hospital, Ho Chi Minh City, Viet Nam; Teoh, J.Y.-C., Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; Thaidumrong, T., Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand; Ong, T.-A., Urology Unit, Department of Surgery, University of Malaya Medical Center, Kuala Lumpur, Malaysia	Objective: The Coronavirus Disease 2019 (Covid-19) pandemic affected surgical training in many ways. This observational study was carried out to evaluate the impact of Covid-19 on urological residencies across Asia. Methodology: An open-ended survey questionnaire examining key areas in a urology training program was distributed to several urologists in Asia. The survey evaluated seven areas including the burden of Covid-19 disease, the need for re-deployment of residents, the impact on clinical work, the effect on research work for residents, the delivery of teaching to the residents, the impact on training and assessments, the effects on mental, personal health and social welfare of residents. Results: Reports from 11 Asian countries were analysed. There is stark variability in Covid-19 disease burden across Asia. Re-deployment occurred in selected Asian countries. Affected residents reported challenges obtaining personal protective equipment and training. Clinical workload and research were generally reduced except for countries reporting low volume Covid-19 cases. Residents teaching evolved from in-person to online platforms. Almost all residency program postponed their examinations. Mental health disturbance was more pronounced than personal health. Conclusions: The Covid-19 pandemic presented multiple obstacles to Asian urology residencies. The understanding of these challenges will assist program directors in developing mitigating measures. © 2020 College of Surgeons of Hong Kong	Covid-19; pandemic; residency; urology	anxiety; Article; coronavirus disease 2019; health; human; human experiment; learning; medical practice; medical student; mental health; multicenter study; observational study; propensity score; prostate biopsy; questionnaire; residency education; resuscitation; social status; social welfare; surgical training; teaching; teleconsultation; transrectal ultrasonography; urodynamics; uroflowmetry; urologist; urology; workload	Blackwell Publishing Ltd	17441625		Article	Q4	109	28907	View
1099(2)
No records
636	Wardhani S.O., Fajar J.K., Soegiarto G., Wulandari L., Maliga H.A., Ilmawan M., Merysa R., Simamora A.B., Aini Q., Noviantari K., Lestari A.W., Harnila M.Y., Syafi'i I., Djianzonie J.A.C., Siagian N., Nining S., Hanim R.Z., Wahyuni W., Aulia F., Juliansyah J., Mahmud R., Tamara F., Mahendra A.I., Wowor A.C., Baladraf F., Hadinata P.H., Ikkeputri A., Nadya H., Kartini D.A., Husnah M., Nainu F., Harapan H.	57193196381;56156139600;57193717004;52464692000;57222334227;57217182580;57412905100;57413600800;57413736700;57412771300;57413600900;57413601000;57412905200;57221505199;57343359200;57413601100;57413182200;57436727400;57413458400;57412905300;57413049000;57192950403;57202301766;57413182300;57412771400;57412905400;57412771500;57413601200;57223337784;57194724156;57120069200;55844857500;	The association between therapeutic plasma exchange and the risk of mortality among patients critically ill with COVID-19: A meta-analysis.	2021	F1000Research	10		1280				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122857082&doi=10.12688%2ff1000research.74972.1&partnerID=40&md5=538e74eb0948ed728ed9150f0537f262	Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Universitas Indonesia, Jakarta, s10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia	Wardhani, S.O., Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Soegiarto, G., Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Merysa, R., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Simamora, A.B., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Aini, Q., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Noviantari, K., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Lestari, A.W., Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Harnila, M.Y., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Syafi'i, I., Faculty of Pharmacy, Universitas Indonesia, Jakarta, s10430, Indonesia; Djianzonie, J.A.C., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Siagian, N., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Nining, S., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Hanim, R.Z., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Wahyuni, W., Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Aulia, F., Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Juliansyah, J., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Mahmud, R., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Wowor, A.C., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Baladraf, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Hadinata, P.H., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Ikkeputri, A., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Nadya, H., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Kartini, D.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Husnah, M., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia	Background: Cytokine storm has been widely known to contribute to the development of the critical condition in patients with coronavirus disease 2019 (COVID-19), and studies had been conducted to assess the potential aspect of cytokine storm elimination by performing therapeutic plasma exchange (TPE). However, contradictory findings were observed. The objective of this study was to assess the association between TPE and the reduction of mortality of critically ill COVID-19 patients. Methods: A meta-analysis was conducted by collecting data from PubMed, Scopus, and Web of Science. Data on the mortality rate of critically ill COVID-19 patients treated with TPE plus standard of care and that of patients treated with standard of care alone were analyzed using a Z test. Results: We included a total of four papers assessing the association between TPE and the risk of mortality among critically ill COVID-19 patients. Our findings suggested that critically ill COVID-19 patients treated with TPE had lower risk of mortality compared to those without TPE treatment. Conclusion: Our study has identified the potential benefits of TPE in reducing the risk of mortality among critically ill COVID-19 patients. © 2021 Wardhani SO et al.	COVID-19therapeutic plasma exchangecytokine stormtreatment	coronavirus disease 2019; critically ill patient; cytokine storm; human; meta analysis; mortality rate; plasma exchange; Review; systematic review; critical illness; cytokine release syndrome; plasma exchange; COVID-19; Critical Illness; Cytokine Release Syndrome; Humans; Plasma Exchange; SARS-CoV-2	F1000 Research Ltd	20461402	35083038	Review	Q1	1099	3793	View
688	Bachtiar B.M., Theodorea C.F., Tahapary D.L., Astrella C., Natalina, Bachtiar E.W.	15831189400;57190048861;55944492500;57210793320;57193344580;6507328763;	A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform	2021	F1000Research	10			1	23		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117343626&doi=10.12688%2fF1000RESEARCH.28216.4&partnerID=40&md5=67091555cb3a43a5a6d2e958586434d2	Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia	Bachtiar, B.M., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Theodorea, C.F., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Astrella, C., Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Natalina, Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Bachtiar, E.W., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia	Background: Subgingival niche is one biofilm habitat containing rich microbiota, which plays an active role in maintaining the health of periodontal tissue and determining host response. As such, a study of changing subgingival biofilms is important for understanding the effect of a systemic condition. In this study, we compared the occurrence of six bacteria cohabiting in the subgingival area of periodontitis subjects, with (DP, n = 8) and without (NDP, n = 4) diabetes. Methods: The six genus and species of targeted bacteria were confirmed by 16S rRNA amplicon sequencing on MinION nanopore platform. Descriptive statistic was used to describe the obtained data. Results: We found that the six genus and species of targeted bacteria were detected but in different quantities in either group's periodontal pocket. Our data showed that Tannerella forsythia was the most abundant species in subgingival biofilms of the DP group of the red complex bacteria. In contrast, Aggregatibacter sp., which belongs to the phylum of proteobacteria, was present at a relatively lower level. In contrast, Fusobacterium sp., which belongs to orange complex bacteria, showed relative similarities in subgingival biofilms of both groups tested, while Veillonella sp., were abundant in the DP groups. Conclusions: Our data show that the diversity of classic periodontopathogens increased in the subgingival niche of periodontitis subjects with diabetes. It is the first study in Indonesia to apply MinION-based, full-length 16S rRNA amplicon sequencing in periodontitis patients with and without diabetes. © 2021. Bachtiar BM et al.	16S rRNA; Diabetes; MinION; Periodontitis; Red Complex bacteria; Subgingival Microbiome		F1000 Research Ltd	20461402		Article	Q1	1099	3793	View

Publikasi Scopus 926 artikel (Per 14 Maret 2022)