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511 |
Zakaria H., Valentine O., Mayza A. |
24465810100;57210969043;57211585788; |
Analysis of quantitative EEG (QEEG) parameters on the effect of transcranial direct current stimulation (TDCS) on post-stroke patients |
2021 |
AIP Conference Proceedings |
2344 |
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050001 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103483309&doi=10.1063%2f5.0047216&partnerID=40&md5=c64c2b06ed2088913d8d35589059c49a |
School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Senen, Central Jakarta, 10430, Indonesia |
Zakaria, H., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Valentine, O., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Mayza, A., Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Senen, Central Jakarta, 10430, Indonesia |
Cerebrovascular accident (CVA) or stroke is a condition where the blood flow to the brain is impaired, which can be caused by a blockage (ischemic stroke) or rupture of blood vessels (hemorrhagic stroke), resulting in cell death in some brain areas. Stroke can cause significant impairment in motoric, cognitive, and coordination skills of limbs and muscles. One of the non-invasive stimuli that can be applied in post-stroke patient rehabilitation is Transcranial Direct Current Stimulation (TDCS), aiming to improve the frequency spectrum towards normal. This study aimed to find the Quantitative Electroenchepalograph (QEEG) parameters that characterize the improvement of post-stroke patients' brain signals after the administration of TDCS. QEEG parameters included absolute power, relative power, ratio power Delta Theta Alpha Beta (DTAB), Delta Alpha (DA), and the percentage of each frequency wave band in the brain. EEG signals were recorded for 5 minutes before and after TDCS administration from 23 subjects, consisted of 12 post-stroke patients and 11 healthy subjects as a control. The result showed that there were significant differences in QEEG parameters before and after TDCS administration to both post-stroke patients and healthy subjects. The alpha frequency was dominant for healthy subjects, with the average of 25.67% before stimulus then increased by 1.91% after the stimulus. For post-stroke patients, delta frequency before the stimulus was dominant, with an average percentage of 43.03% then decreased by 10.44% after the stimulus. These results show that with TDCS, there is a change in the EEG wave pattern in post-stroke patients, which followed the profile pattern of healthy subjects. © 2021 Author(s). |
Quantitative EEG (QEEG); Stroke; Transcranial Direct Current Stimulation (TDCS) |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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512 |
Inayati R., Suhaeri M., Fahdia N., Remelia M., Antarianto R.D. |
57222623427;56183087500;57222625988;57209653885;57190862806; |
Optimization of hybrid PVA/hFDM scaffold preparation |
2021 |
AIP Conference Proceedings |
2344 |
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020012 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103481516&doi=10.1063%2f5.0049156&partnerID=40&md5=d049606831bf9a961d70f9a9c49ec7bf |
Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Rumah Sakit Universitas Indonesia, Kampus Universitas Indonesia, Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Department of Basic Biomedicine, Faculty of Medicine, Universitas Kristen Indonesia, Jl Mayjen Sutoyo No 2, DKI Jakarta, 13630, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Inayati, R., Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Suhaeri, M., Rumah Sakit Universitas Indonesia, Kampus Universitas Indonesia, Depok, West Java, 16424, Indonesia; Fahdia, N., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Remelia, M., Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Department of Basic Biomedicine, Faculty of Medicine, Universitas Kristen Indonesia, Jl Mayjen Sutoyo No 2, DKI Jakarta, 13630, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Osteogenic differentiation from Mesenchymal Stem Cell (MSC) to osteoblast has a clinical significance which is very important for treating bone injuries, in the form of femoral fractures with the most cases in Indonesia. Various studies have been conducted to find the best scaffold that can improve osteogenic differentiation, one of which is the development of a hybrid scaffold made from natural biomaterials in the form of the extracellular matrix, and from synthetic biomaterials. The discovery of the best scaffold is not only focused on the source of the scaffold but also requires optimization of the method in making the scaffold. Therefore, the aim of this study is to find out the optimum method for making hybrid scaffolds that support osteogenic differentiation from MSC. Materials and methods: human Fibroblast-derived Matrix (hFDM) as a hybrid scaffold material collected from decellularized fibroblasts cultures from post-cleft-surgery reconstruction palatal skin. Fibroblast cell cultures were divided into two groups of cultures, cultures without Platelet Rich Plasma (PRP), and cultures with the addition of PRP. For decellularization, we performed optimization at the preparation stage of the decellularization solution, and the time of culture for decellularization. In the preparation of the decellularization solution, we divided it into two groups, NH4OH as material from the decellularization solution was diluted with PBS before mixing with 0.25% Triton X-100, and NH4OH was diluted directly in 0.25% Triton X-100. In optimizing the culture time for decellularization, we divided it into three groups, decellularization on the day when cell growth reached 100% confluent, decellularization on the 3rd day after 100% confluent (H + 3) cells, and decellularization on the 4th day after 100% confluent (H + 4) cells. Next, the hFDM matrix is collected and added Polyvinyl Alcohol (PVA) solutions to form a hybrid PVA / hFDM scaffold in the form of a hydrogel. Observations on hybrid PVA / hFDM scaffolds were made using an inversion microscope. Results and discussion: Optimization of methods for culture techniques found that the addition of PRP to fibroblast culture medium increased the rate of fibroblast proliferation. For the decellularization technique, it is known that the preparation of the decellular solution by diluting NH4OH directly in 0.25% Triton X-100 to obtain a final concentration of 50mM NH4OH is known to be effectively used in decellularizing fibroblasts. The optimum culture time is also known that a thicker hFDM matrix can be obtained on day 4 after 100% confluent (H + 4) cells. Conclusion: Making a good hFDM hybrid PVA scaffold requires method optimization, ranging from fibroblast culture techniques and decellularization techniques. Proper optimization can produce a hybrid PVA / hFDM scaffold which is suitable for bone tissue engineering applications. © 2021 Author(s). |
decellularization; fibroblast culture; hybrid PVA/hFDM scaffold |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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513 |
Rizal, Syaidah R., Aqsha Z.M., Josephin A., Pakpahan V.M. |
57222623832;55418885900;57222626455;57222619624;57222621602; |
Characterization, differentiation, and population doubling time of Wharton's jelly mesenchymal stem cells (WJ-MSCs) in passage 5 and 8 |
2021 |
AIP Conference Proceedings |
2344 |
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040002 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103479666&doi=10.1063%2f5.0047340&partnerID=40&md5=346f0fd284692390adaef1a8feae20b2 |
Biomedical Engineering Program, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Rizal, Biomedical Engineering Program, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Syaidah, R., Department of Histology, Faculty of Medicine, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Aqsha, Z.M., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Josephin, A., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Pakpahan, V.M., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Wharton's jelly mesenchymal stem cells (WJ-MSCs) is proposed to be the best source of mesenchymal stem cells (MSCs). It has better self-renewal and differentiation capacity compare to adult stem cells such as bone marrow- derived stem cells (BM-MSCs). However, their characteristics in different passages do not yet well described. This research aims to isolate and characterize WJ-MSCs with regard to their proliferation capacity, immunophenotypes, and differentiation capacity. The WJ-MSCs were isolated by the explant method. The cultured WJ-MSCs at P5 and P8 were then characterized using flow cytometric analysis with regard to its surface marker, which are CD44, CD90, CD105, CD73, and negative lineages. The proliferation capacity of WJ-MSCs was analyzed with the population doubling time method and the characterized cells were differentiated into three different lineages. The result revealed that the isolated cells highly express MSCs surface marker with >98% for all surface markers and 0.00% for negative lineages. Isolated WJ-MSCs also exhibited a high proliferation capacity with a range of 1.06 to 1.59 days. Both passages revealed excellent differentiation capacity into chondrocytes, adipocytes, and osteocytes. © 2021 Author(s). |
characterization; differentiation; Mesenchymal stem cells; proliferation; Wharton's jelly |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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620 |
Setyawan H.B., Yulianto R., Santoso W.D., Suryandari N. |
57221951849;57214720503;6506080422;57221947574; |
Fern plant (Pteris vittata) as a phytoremediator of arsenic heavy metal and its effect to the growth and quality of Kale (Ipomea reptans Poir) |
2021 |
IOP Conference Series: Earth and Environmental Science |
637 |
1 |
012066 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100756752&doi=10.1088%2f1755-1315%2f637%2f1%2f012066&partnerID=40&md5=39224fc2c888c20765d655154da66bc5 |
Animal Husbandry Department, Faculty of Agriculture, University of Jember, Indonesia; Internal Medicine Department, Faculty of Medicine, University of Indonesia, Indonesia; Agrotechnology Departement, Faculty of Agriculture, University of Jember, Indonesia |
Setyawan, H.B., Animal Husbandry Department, Faculty of Agriculture, University of Jember, Indonesia; Yulianto, R., Animal Husbandry Department, Faculty of Agriculture, University of Jember, Indonesia; Santoso, W.D., Internal Medicine Department, Faculty of Medicine, University of Indonesia, Indonesia; Suryandari, N., Agrotechnology Departement, Faculty of Agriculture, University of Jember, Indonesia |
Kale (Ipomea reptans Poir) has high nutrition such as vitamin A, B and C as well as various minerals especially iron. Quality of animal feed must be clean from diseases and heavy metal contamination such as Arsenic. Arsenic in the soil can be reduced naturally using phytoremediator plants, one of which is Pteris vittata. The experiment was conducted at the Antirogo Green House, Sumbersari Distric, Jember Regency. Arsenic metal analysis was conducted in BARISTAND, Surabaya and BALITTANAH, Bogor on June 2019 to January 2020. The experimental design used Factorial Complete Random Design consist of 2 factors. The first factor consists of 4 levels of heavy metal arsenic treatment on the fern plant growth media, namely was 0 ppm (D1), 5 ppm (D2), 10 ppm (D3) and 15 ppm (D4). The second factor consists of 2 levels of treatment time of fern: 1 month (P1) and 2 weeks (P2). Each of treatment repeated 4 times. The results showed that the interaction between planting time of fern and arsenic dosage showed no significant effect. The absorption power of ferns reaches 0.27 ppm to 4.589 ppm higher compared to the scale absorptions reaching 0,006 ppm to 0.155 ppm. © 2021 Institute of Physics Publishing. All rights reserved. |
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Agriculture; Arsenic; Heavy metals; Metal analysis; Sustainable development; 2-factors; Absorption power; Animal feed; Heavy metal contamination; Plant growth; Pteris vittata; Treatment time; Vitamin A; Chemical contamination |
IOP Publishing Ltd |
17551307 |
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Conference Paper |
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179 |
20770 |
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865 |
Silitonga P., Dewi B.E., Bustamam A., Al-Ash H.S. |
57219406661;24076058600;36815737800;57205062769; |
Evaluation of Dengue Model Performances Developed Using Artificial Neural Network and Random Forest Classifiers |
2021 |
Procedia Computer Science |
179 |
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135 |
143 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101780236&doi=10.1016%2fj.procs.2020.12.018&partnerID=40&md5=bf5f6b6b59db9e4a155ff56ac22ceeaf |
Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.5, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Computer Science, Faculty of Computer Science, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia |
Silitonga, P., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Dewi, B.E., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.5, Jakarta Pusat, Jakarta, 10430, Indonesia; Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Al-Ash, H.S., Department of Computer Science, Faculty of Computer Science, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia |
Dengue is one of the endemic diseases in Indonesia. Dengue is being suffered by many people, regardless of their gender and age. Therefore, research about dengue based on dengue patients' data was conducted. There was a lot of information written in that data regarding the corresponding patients and the dengue they had suffered, such as gender, age, how long the patients were hospitalized, the symptoms they experienced, and laboratory characteristics results. Diagnosis of each of the corresponding patients based on their symptoms and laboratory characteristics results were also written in that data. The diagnoses were classified into three different clinical degrees according to the severity level, which is DF as the mild level, DHF grade 1 as the intermediate level, and DHF grade 2 as the severe level. In this research, data of the patients on the third day of being hospitalized was analyzed, because, on the third day, dengue is entering a critical phase. The objectives of this research were: to evaluate the performance of the models that were used to predict the correct class within the given dataset developed using Artificial Neural Network (ANN) classifier and Random Forest (RF) classifier separately, and to find a classifier that yielded the best performance. The results obtained from this research will be used in the development of a Machine Learning model that can predict the clinical degree of dengue in the critical phase, if the laboratory characteristics results are known, using a classifier that yielded the best performance. © 2021 Elsevier B.V.. All rights reserved. |
Artificial Neural Network; Dengue; Random Forest |
Classification (of information); Clinical research; Decision trees; Diagnosis; Intelligent computing; Random forests; Turing machines; Indonesia; Intermediate level; Machine learning models; Model performance; Random forest classifier; Neural networks |
Elsevier B.V. |
18770509 |
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Conference Paper |
- |
334 |
13810 |
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874 |
Gondhowiardjo S., Christina N., Ganapati N.P.D., Hawariy S., Radityamurti F., Jayalie V.F., Octavianus S., Putra A.P., Sekarutami S.M., Prajogi G.B., Giselvania A., Adham M., Hamid A.R.A.H., Widyastuti E., Prabowo Y., Aninditha T., Purwoto G., Aman R.A., Siregar T.P., Siswoyo A.D., Lisnawati, Handjari D.R., Atmakusuma D., Rajabto W., Mulansari N.A., Ratna N., Pitoyo C.W., Panigoro S.S., Kartini D., Yulian E.D., Andrisa R.S., Jeo W.S., Wardhani R.K., Tambunan T.F.U., Agianda F., Priyambodho |
6508327402;57217200193;57222017707;57222032883;57222015964;57195939736;57217198334;57222391312;56576294500;57221911632;57217201891;14024202100;57202054669;57222381718;56682042400;57189611205;14720170400;36848942500;57222017915;57210639278;24449072000;56160657900;23472246000;36519576100;36519326000;57222024187;26022606900;56790104300;57215490523;55983956600;57222018745;57201257973;57222033979;57222024180;57222019146;57222384319; |
Five-year cancer epidemiology at the nationa referral hospital: Hospital-based cancer registry data in Indonesia |
2021 |
JCO Global Oncology |
7 |
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190 |
203 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101027387&doi=10.1200%2fGO.20.00155&partnerID=40&md5=60ffa9d74a039cb3543813b399bd6492 |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Hemato-Oncology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Orthopedics, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Neuro-Oncology, Department of Neurology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Hematology-Oncology Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition Science Clinic, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Oncology Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Eye Oncology, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Christina, N., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ganapati, N.P.D., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hawariy, S., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Radityamurti, F., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jayalie, V.F., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Octavianus, S., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, A.P., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prajogi, G.B., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Giselvania, A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adham, M., Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamid, A.R.A.H., Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Widyastuti, E., Division of Hemato-Oncology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prabowo, Y., Department of Orthopedics, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aninditha, T., Division of Neuro-Oncology, Department of Neurology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Purwoto, G., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aman, R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Siregar, T.P., Department of Radiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Siswoyo, A.D., Department of Radiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lisnawati, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Handjari, D.R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Atmakusuma, D., Division of Hematology-Oncology Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rajabto, W., Division of Hematology-Oncology Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mulansari, N.A., Division of Hematology-Oncology Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ratna, N., Department of Nutrition Science Clinic, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pitoyo, C.W., Division of Respirology and Critical Illness, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Panigoro, S.S., Division of Oncology Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kartini, D., Division of Oncology Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yulian, E.D., Division of Oncology Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Andrisa, R.S., Division of Eye Oncology, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jeo, W.S., Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wardhani, R.K., Department of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tambunan, T.F.U., Department of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Agianda, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priyambodho, Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
PURPOSE In 2016, there were 1,308,061 cases of cancer being treated in Indonesia, with 2.2 trillion rupiahs spent, amounting to $486,960,633 in US dollars (purchasing power parity 2016). The high burden of cancers in Indonesia requires a valid data collection to inform future cancer-related policies. The purpose of this study is to report cancer epidemiological data from 2008 to 2012 based on Hospital-Based Cancer Registry (HBCR) data from Cipto Mangunkusumo Hospital, Indonesia. METHODS This was a descriptive study with cross-sectional design. Data were collected from Cipto Mangunkusumo Hospital HBCR 2008-2012. Demographical, diagnostic, stages of cancer, and histopathological types of cancer data were extracted. RESULTS After screening, 18,216 cases were included. A total of 12,438 patients were older than 39 years of age (68.3%), with a female-to-male ratio of 9:5. Most patients have cancers at advanced stages (stages III and IV, 10.2%). The most common sites of cancer were cervix uteri (2,878 cases, 15.8%), breast (2,459 cases, 13.5%), hematopoietic and reticuloendothelial systems (1,422 cases, 7.8%), nasopharynx (1,338 cases, 7.4%), and lymph nodes (1,104 cases, 6.1%). CONCLUSION From this HBCR, cancer incidence in female was almost twice the incidence in male, largely because of the burden of cervical and breast cancers. The cervix uteri as one of the top five cancer sites based on this HBCR, 2008-2012, are still approximately consistent with Global Cancer Incidence, Mortality and Prevalence 2018, which portrayed that Indonesia has been severely afflicted by cervical cancer cases more than any other Association of Southeast Asian Nations countries. The HBCR could serve as a robust database of epidemiological data for cancer cases in Indonesia. © 2021 by American Society of Clinical Oncology |
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adrenal cancer; adult; anus cancer; Article; articular cartilage; autonomic nervous system; bile duct cancer; bladder cancer; bone cancer; brain cancer; breast cancer; bronchus cancer; cancer diagnosis; cancer epidemiology; cancer incidence; cancer localization; cancer mortality; cancer of unknown primary site; cancer registry; cancer staging; cartilage cancer; central nervous system cancer; clinical examination; colon cancer; connective tissue cancer; cranial nerve cancer; cross-sectional study; demography; descriptive research; endocrine cancer; esophagus cancer; eye cancer; female; female genital tract cancer; gallbladder cancer; gingiva tumor; heart cancer; hematologic malignancy; hepatobiliary system cancer; histopathology; human; hypopharynx cancer; Indonesia; intrahepatic bile duct; |
American Society of Clinical Oncology |
26878941 |
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33539173 |
Article |
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0 |
32782 |
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875 |
Lim M.A., Kurniawan A.A. |
57216039756;57222011563; |
Dreadful Consequences of Sarcopenia and Osteoporosis due to COVID-19 Containment |
2021 |
Geriatric Orthopaedic Surgery and Rehabilitation |
12 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101012807&doi=10.1177%2f2151459321992746&partnerID=40&md5=a0f3b09ec242d45be8f989650cec89a9 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Eminence Sports Medicine and Human Performance Center, Jakarta, Indonesia; Department of Sports Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Eminence Sports Medicine and Human Performance Center, Jakarta, Indonesia; Kurniawan, A.A., Eminence Sports Medicine and Human Performance Center, Jakarta, Indonesia, Department of Sports Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
[No abstract available] |
Fragility Fractures; Geriatric Trauma; Metabolic Bone disorders; Osteoporosis; Sarcopenia |
vitamin D; absorptiometry; anthropometry; bone density; bone fragility; coronavirus disease 2019; dietary intake; dual energy X ray absorptiometry; fracture nonunion; fracture risk assessment; fragility fracture; health care personnel; hip fracture; Letter; lifestyle modification; musculoskeletal injury; osteomyelitis; osteopenia; osteoporosis; physical activity; physical performance; quality of life; sarcopenia; vitamin supplementation |
SAGE Publications Inc. |
21514585 |
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Letter |
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0 |
32716 |
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No records
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5 |
Rahmat B., Dwita N.U., Arya Wardana P.W., Lilyasari O. |
57192273755;57402910300;57403605200;57192914838; |
Preoperative Left Ventricle End Diastolic Volume Index as a Predictor for Low Cardiac Output Syndrome After Surgical Closure of Secundum Atrial Septal Defect With Small-Sized Left Ventricle |
2021 |
Frontiers in Pediatrics |
9 |
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705257 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122447256&doi=10.3389%2ffped.2021.705257&partnerID=40&md5=6da645c8d6ae19fd8dfd4e9dc9a05bcb |
Pediatric and Congenital Heart Surgery Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia |
Rahmat, B., Pediatric and Congenital Heart Surgery Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Dwita, N.U., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Arya Wardana, P.W., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Lilyasari, O., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia |
Introduction: Low cardiac output syndrome is one of the postoperative complications that are associated with significant morbidity and mortality after surgical closure of atrial septal defect (ASD) with small-sized left ventricle (LV). This study investigated whether preoperative left ventricular end-diastolic volume index (LVEDVi) could accurately predict low cardiac output syndrome (LCOS) after surgical closure of ASD with small-sized LV. Method: This retrospective cohort study involved adult ASD patients with small-sized LV from January 2018 to December 2019 in National Cardiovascular Center Harapan Kita. Preoperative MRI data to assess the left and right ventricle volume were collected. A bivariate analysis using independent Student's t-test was done. Diagnostic test using receiver operating characteristic (ROC) curve was also done to obtain the area under the curve (AUC) value. The best cutoff point was determined by Youden's index. Result: Fifty-seven subjects were involved in this study [age (mean ± SD) 32.56 ± 13.15 years; weight (mean ± SD) 48.82 ± 12.15 kg]. Subjects who had post-operative LCOS (n = 30) have significantly lower LVEDVi (45.0 ± 7.42 ml/m2 vs. 64.15 ± 13.37 ml/m2; p < 0.001), LVEDV (64.6 ± 16.0 ml vs. 85.9 ± 20.7 ml; p < 0.001), LVSV (38.97 ± 11.5 ml vs. 53.13 ± 7.5 ml; p < 0.001), and LVSVi (27.28 ± 8.55 ml/m2 vs. 37.42 ± 5.35 ml/m2; p < 0.001) compared to subjects who did not have post-operative LCOS (n = 27). ROC analysis showed that the best AUC was found on LVEDVi (AUC 95.3%; 95% confidence interval: 90.6–100%). The best cutoff value for LVEDVi to predict the occurrence of LCOS after surgical closure of ASD was 53.3 ml/m2 with a sensitivity of 86.7% and a specificity of 85.2%. Conclusion: This study showed that preoperative LVEDVi could predict LCOS after surgical closure of ASD with small-sized LV with a well-defined cutoff. The best cutoff value of LVEDVi to predict the occurrence of LCOS after surgical ASD closure was 53.5 ml/m2. Copyright © 2021 Rahmat, Dwita, Arya Wardana and Lilyasari. |
ASD closure; atrial septal defect; left ventricle end diastolic volume; low cardiac output syndrome; magnetic resonance imaging (MRI) |
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Frontiers Media S.A. |
22962360 |
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Article |
Q1 |
960 |
4641 |
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6 |
Pranata R., Huang I., Lim M.A., Yonas E., Vania R., Lukito A.A., Nasution S.A., Siswanto B.B., Kuswardhani R.A.T. |
57201973901;57208576645;57216039756;57201987097;57208328436;57213835420;57189373134;14422648800;36863900500; |
Elevated De Ritis Ratio Is Associated With Poor Prognosis in COVID-19: A Systematic Review and Meta-Analysis |
2021 |
Frontiers in Medicine |
8 |
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676581 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122327729&doi=10.3389%2ffmed.2021.676581&partnerID=40&md5=254957cc5c17b448a803a88e33741d8f |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Lukito, A.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Nasution, S.A., Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Kuswardhani, R.A.T., Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Objective: This meta-analysis aims to assess whether elevated De Ritis ratio is associated with poor prognosis in patients with coronavirus 2019 (COVID-19). Methods: A systematic literature search was performed using PubMed, Embase, and EuropePMC databases up until September 17, 2021. De Ritis ratio is also known as Aspartate aminotransferase/alanine transaminase (AST/ALT) ratio. The main outcome was poor prognosis, a composite of mortality, severity, the need for ICU care, and intubation. The effect measure was odds ratios (ORs) and mean differences. We generated sensitivity and specificity, negative and positive likelihood ratio (NLR and PLR), diagnostic odds ratio (DOR), and area under curve (AUC). Results: There were eight studies with 4,606 patients. De Ritis ratio was elevated in 44% of the patients. Patients with poor prognosis have higher De Ritis ratio [mean difference 0.41 (0.31, 0.50), p < 0.001; I2: 81.0%] and subgroup analysis showed that non-survivors also have higher De Ritis Ratio [mean difference 0.47 (0.46, 0.48), p < 0.001; I2: 0%]. Elevated De Ritis ratio was associated with poor prognosis [OR 3.28 (2.39, 4.52), p < 0.001; I2: 35.8%]. It has a sensitivity of 55% (36–73), specificity of 71% (52–85), PLR 1.9, NLR.63, DOR of 3 (2–4), and AUC of.67 (0.63–0.71). The posterior probability of poor prognosis was 38% if De Ritis is elevated, while 17% if De Ritis is not elevated. Conclusion: Elevated De Ritis ratio is associated with poor prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO ID: CRD42020216634. Copyright © 2021 Pranata, Huang, Lim, Yonas, Vania, Lukito, Nasution, Siswanto and Kuswardhani. |
coronavirus—COVID-19; De Ritis ratio; liver enzyme; SARS-CoV-2; transaminase |
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Frontiers Media S.A. |
2296858X |
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Review |
Q1 |
1388 |
2608 |
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7 |
Wisnu W., Alwi I., Nafrialdi N., Harimurti K., Pemayun T.G.D., Jusman S.W.A., Santoso D.I.S., Harahap A.R., Suwarto S., Subekti I. |
57200425452;15055173800;57395824800;23473513200;57208091289;36518792100;6604001213;57395521700;8443626100;24336854300; |
The Differential Effects of Propylthiouracil and Methimazole as Graves’ Disease Treatment on Vascular Atherosclerosis Markers: A Randomized Clinical Trial |
2021 |
Frontiers in Endocrinology |
12 |
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796194 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122186237&doi=10.3389%2ffendo.2021.796194&partnerID=40&md5=f92b3a12a849c6a2e102b7358c8abd20 |
Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Endocrine, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Wisnu, W., Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nafrialdi, N., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harimurti, K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pemayun, T.G.D., Division of Endocrine, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Santoso, D.I.S., Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harahap, A.R., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Suwarto, S., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Subekti, I., Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Hyperthyroidism is related to vascular atherosclerosis. Propylthiouracil (PTU) and methimazole, other than their antithyroid effects, may have different mechanisms in preventing atherogenesis in Graves’ disease. Objective: This study aimed to investigate the effect of antithyroid drugs on markers of vascular atherosclerosis in Graves’ hyperthyroidism. Methods: This study was a single-blind, randomized clinical trial conducted on 36 patients with Graves’ disease in Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from June 2019 until July 2020. Graves’ disease was diagnosed from clinical manifestation of hyperthyroidism with diffuse goiter and then confirmed by thyroid stimulation hormone (TSH), free T4 (fT4), and TSH-receptor antibody (TRAb) measurements. Participants were randomly assigned to either a PTU or a methimazole treatment group and followed up for 3 months. Markers of vascular atherosclerosis were represented by adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin], carotid artery stiffness [pulse wave velocity (PWV)], and thickness [carotid intima media thickness (cIMT)]. Results: By the end of the study, 24 participants reached euthyroid condition (13 from the PTU group and 11 from the methimazole group). After 3 months of follow-up, in the PTU group, we noticed an improvement of ICAM-1 [pretreatment: 204.1 (61.3) vs. posttreatment: 141.6 (58.4) ng/ml; p = 0.001], VCAM-1 [837 (707–977) vs. 510 (402–630) ng/ml; p < 0.001] and E-selectin [32.1 (24.1–42.7) vs. 28.2 (21.6–36.8) ng/ml; p = 0.045] in the PTU group. In the methimazole group, only VCAM-1 improvement [725 (565–904) vs. 472 (367–590); p = 0.001] was observed. Meanwhile, we found no significant changes in PWV or cIMT in either group. Conclusion: Antithyroid treatment in Graves’ disease leads to improvement in adhesion molecules, with a lesser effect on methimazole, whereas there were no significant changes in PWV or cIMT. PTU may have a better mechanism compared with methimazole in terms of improving adhesion molecules. Copyright © 2021 Wisnu, Alwi, Nafrialdi, Harimurti, Pemayun, Jusman, Santoso, Harahap, Suwarto and Subekti. |
adhesion molecules; carotid intima media thickness; Graves’ disease; hyperthyroidism; methimazole; propylthiouracil; pulse wave velocity; vascular atherosclerosis |
cell adhesion molecule 1; endothelial leukocyte adhesion molecule 1; propylthiouracil; thiamazole; thyrotropin; adolescent; adult; arterial stiffness; Article; atherosclerosis; blood pressure; clinical article; controlled study; coronavirus disease 2019; echography; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; female; follow up; Graves disease; human; hyperthyroidism; inflammation; male; middle aged; physical examination; pregnancy; pulse wave velocity; randomized controlled trial; young adult |
Frontiers Media S.A. |
16642392 |
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Q1 |
1518 |
2233 |
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