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95 |
Laksmita Y.A., Sidik M., Siregar N.C., Nusanti S. |
57209279067;57257519600;6508087790;57189727162; |
Neuroprotective Effects of Citicoline on Methanol-Intoxicated Retina Model in Rats |
2021 |
Journal of Ocular Pharmacology and Therapeutics |
37 |
9 |
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534 |
541 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120545903&doi=10.1089%2fjop.2021.0018&partnerID=40&md5=cfe07289839f2866220d3438db7fac57 |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Laksmita, Y.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Sidik, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nusanti, S., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia |
Purpose: This study aims to evaluate the effect of citicoline administration in suppressing retinal damage due to methanol intoxication. This study hypothesizes that citicoline will minimize the loss of retinal ganglion cells (RGCs), minimize disruption of photoreceptors, suppress ganglion layer edema, increase expression of bcl-2 as the antiapoptotic protein, and decrease expression of caspase-3 as the proapoptotic protein. Methods: Fifteen Sprague-Dawley rats were divided into 5 groups, including the control group (A); methanol groups, observed on day 3 (B1) and day 7 (B2); and methanol+citicoline groups, observed on day 3 (C1) and day 7 (C2). Rats in groups B and C were placed in an inhalation chamber filled with N2O:O2 during the experiment, then methanol was administered orally. Citicoline, 1 g/kg every 24 h, was orally administered for group C. Enucleation was performed and retinas of rats were prepared for histology and immunohistochemistry examination to evaluate photoreceptor morphology and RGC density, as well as bcl-2 and caspase-3 expression. Results: RGC density of citicoline-treated intoxicated rats was higher than no-citicoline methanol-intoxicated rats on both day 3 (P < 0.001) and day 7 (P < 0.001). The ganglion layer thickness of citicoline-treated intoxicated rats was thinner than no-citicoline intoxicated rats, which means citicoline-treated rats had milder ganglion layer edema. Citicoline-treated rats showed higher bcl-2 and lower caspase-3 expression than no-citicoline rats. No differences were found in photoreceptor findings among groups. Conclusions: This study demonstrated citicoline's potential benefits for management of ocular methanol intoxication. However, more preclinical and clinical trials are needed to obtain a preferred dosage and timing of citicoline administration. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
citicoline; methanol intoxication; methanol optic neuropathy; neuroprotector; retina; toxic optic neuropathy |
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Mary Ann Liebert Inc. |
10807683 |
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34495749 |
Article |
Q2 |
727 |
6812 |
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96 |
Irwinda R., Hiksas R., Lokeswara A.W., Wibowo N. |
57190855256;57226152029;57200937543;15049026900; |
Maternal and fetal characteristics to predict c-section delivery: A scoring system for pregnant women |
2021 |
Women's Health |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120494500&doi=10.1177%2f17455065211061969&partnerID=40&md5=24bd3b15eeeb46e6e6583c50495d671b |
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lokeswara, A.W., Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Cesarean section is one of the most common obstetrical interventions that has been performed at an increasing rate globally, due to both medical and non-medical reasons. This study aims to develop a prediction tool for pregnant women potentially needing c-section, such that necessary preparations from the mothers, families, and health providers can be made. Methods: A total of 603 pregnant women were recruited in the first phase of c-section prediction tool development. The association between the maternal and fetal factors on the risk of c-section were analyzed, followed by a stepwise multivariate regression analysis. In the next phase, 61 pregnant women were enrolled for external validation. Discrimination was assessed using area under the curve. The calibration plot was then made and assessed using the Hosmer–Lemeshow test. Results: There were 251 (41.6%) cases of vaginal delivery and 352 (58.4%) of c-section assessed. Multivariate analysis showed that gestational age < 37 wg (OR: 1.66, 95% CI: 1.10–2.51), pre-pregnancy body mass index (underweight) (OR: 0.40, 95% CI: 0.22–0.76), no history of vaginal delivery (OR: 2.66, 95% CI: 1.76–4.02), history of uterine surgery (OR: 8.34, 95% CI: 4.54–15.30), obstetrical complications (OR: 5.61, 95% CI: 3.53–8.90), birthweight ⩾ 3500 g (OR: 4.28, 95% CI: 2.16–8.47), and non-cephalic presentation (OR: 2.74, 95% CI: 1.53–4.89) were independently associated with c-section delivery. Those parameters were included in a 7-item scoring tool, with consecutive predictive scores of 1,–1,2,3,3,2,2,1. The area under the curve result was 0.813 (95% CI: 0.779–0.847), indicating a good predictive ability. The external validation showed AUC: 0.806, 95% CI: 0.694–0.917, Hosmer–Lemeshow test p = 0.666 and calibration plot coefficient of r = 0.939. Conclusion: A total of 7 maternal-fetal factors were found to be strongly associated with c-section delivery, including gestational age < 37, maternal underweight body mass index, previous uterine surgery, obstetrical complications, birthweight ⩾ 3500, history of vaginal delivery, and non-cephalic presentation. Using these factors, a prediction tool was developed and validated with good quality. © The Author(s) 2021. |
cesarean section; maternal-fetal characteristics; mode of delivery; prediction; scoring system |
7 point scoring system; abdominal circumference; adult; area under the curve; Article; biological activity; birth weight; body mass; cesarean section; clinical examination; cohort analysis; diagnostic test accuracy study; exploratory factor analysis; female; fetus weight; forceps delivery; gestational age; human; major clinical study; maternal fetal characteristics; mortality; myomectomy; non cephalic presentation; obstetrical complication; prediction; pregnancy complication; pregnant woman; prenatal care; questionnaire; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; underweight; urologic surgery; vaginal delivery; obstetric delivery; pregnancy; Cesarean Section; Delivery, Obstetric; Female; Gestational Age; Humans; Pregnan |
SAGE Publications Ltd |
17455057 |
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34818932 |
Article |
Q1 |
1363 |
2670 |
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97 |
Miranda A.V., Wiyono L., Rocha I.C.N., Cedeño T.D.D., Lucero-Prisno D.E., III |
57222664687;57207889054;57223283646;57224097138;56051373800; |
Strengthening virology research in the association of Southeast Asian nations: Preparing for future pandemics |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
5 |
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1141 |
1143 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119604704&doi=10.4269%2fajtmh.21-0589&partnerID=40&md5=98ad7364acccdc95ee57ef0ea9e65ed9 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
Miranda, A.V., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyono, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Cedeño, T.D.D., School of Medicine, Centro Escolar University, Manila, Philippines; Lucero-Prisno, D.E., III, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
The Association of Southeast Asian Nations (ASEAN) region is known to be a global hotspot to viral outbreaks because of many factors. To limit the impact of future outbreaks, it is crucial for the ASEAN governments to strengthen regional virology research capacity. The ASEAN governments have collaborated in several virology initiatives, with the most recent being the establishment of the ASEAN Regional Center for Public Health Emergencies and Emerging Diseases. However, several challenges, including technology disparities, nationalistic tendencies, and the lack of public acceptance toward virus sharing, need to be addressed to maximize the region’s collaboration potential in virology research. We recommend the governments to 1) prioritize the strengthening of research capacities; 2) develop stronger cooperation and possible centralization of efforts on top of national capacities; 3) develop an equitable and secure research framework; and 4) improve the public awareness regarding the importance of regional public health responses. Copyright © 2021 by The American Society of Tropical Medicine and Hygiene |
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epidemic; human; medical research; organization and management; pandemic; Southeast Asia; virology; Asia, Southeastern; Biomedical Research; Disease Outbreaks; Humans; Pandemics; Virology |
American Society of Tropical Medicine and Hygiene |
00029637 |
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34506300 |
Article |
Q1 |
1015 |
4298 |
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98 |
Yusharyahya S.N., Bramono K., Indriatmi W., Prasetyo M., Ascobat P., Hestiantoro A., Wiraguna A.A.G.P. |
57211780941;9843236700;57189888041;57192905252;55795863600;8743255100;20437026700; |
Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
11 |
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95 |
103 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119480025&doi=10.7324%2fJAPS.2021.1101113&partnerID=40&md5=020217cd5f217dbc98ba3162ac9d99f1 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ascobat, P., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiraguna, A.A.G.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Postmenopausal hypoestrogenism is associated with skin aging, for which phytoestrogen derived from the seeds of Trigonella foenum graecum (fenugreek) is expected to be an alternative solution to reduce wrinkles and increase the thickness of postmenopausal women’s skin. This study was a randomized, double-blind, controlled 12-weeks trial conducted at a general hospital in Jakarta, Indonesia, from January to November 2019. Subjects were 50 postmenopausal women divided into two groups: the intervention group was given 5% fenugreek cream and base cream was given to the placebo group. The results of the independent t-test showed that both groups were able to achieve statistically significant improvement in wrinkle scores on the forehead, crow’s feet, and nasolabial folds which was assessed by photography scoring based on Bazin’s skin aging atlas for Asian skin volume 2 but there was no significant disparity between both groups at all time points. Dermal thickness was assessed by high-resolution ultrasound GE LOGIQ E9 (18 MHz), which showed similar results for both groups with significant improvements in the 8th week compared to baseline and a significant decrease by the 12th week. No significant differences were observed in the skin wrinkle score and skin thickness after the application of fenugreek cream compared to placebo.We suspect that a concentration of 5% was not adequate for the expected antiskin aging effects. Further studies are necessary to determine a more appropriate fenugreek concentration to permit clinical use as an antiskin aging therapy in postmenopausal women. © 2021 Shannaz Nadia Yusharyahya et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License |
Dermal thickness; fenugreek; postmenopausal skin; skin wrinkle |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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99 |
Herawati F., Yulia R., Wiyono H., Massey F.K., Muliani N., Kantono K., Soemantri D., Andrajati R. |
57194722742;56768083700;57321279000;57321051400;57222261946;56580346400;36640659100;9940247700; |
Discordance to ashp therapeutic guidelines increases the risk of surgical site infection |
2021 |
Pharmaceuticals |
14 |
11 |
1088 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118387727&doi=10.3390%2fph14111088&partnerID=40&md5=f3621ba3decf103d84295afa3e55e549 |
Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Food Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Herawati, F., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Yulia, R., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Wiyono, H., Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Massey, F.K., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Muliani, N., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Kantono, K., Department of Food Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand; Soemantri, D., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Andrajati, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia |
Clean surgery without contamination does not require prophylactic antibiotics, but there are high-risk surgical procedures that may cause infection and/or involve vital organs such as the heart, brain, and lungs, and these indeed require the use of antibiotics. This study aimed to determine the quantity of antibiotic use based on the defined daily dose (DDD) per 100 bed days and the quality of antibiotic use based on the percentage of concordance with The American Society of Health-System Pharmacists (ASHP) therapeutic guidelines (i.e., route of administration, time of administration, selection, dose, and duration). This includes the profiles of surgical site infection (SSI) in surgical patients from January through June 2019. The study subjects were 487 surgical patients from two hospitals who met the inclusion criteria. There were 322 patients out of 487 patients who had a clean surgical procedure. Ceftriaxone (J01DD04) was the most used antibiotic, with a total DDD/100 bed days value in hospitals A and B, respectively: pre-surgery: 14.71, 77.65, during surgery: 22.57, 87.31, and postsurgery: 38.34, 93.65. In addition, 35% of antibiotics were given more than 120 min before incision. The lowest concordance to ASHP therapeutic guideline in hospital A (17.6%) and B (1.9%) was antibiotic selection. Two patients experienced SSI with bacterial growths of Proteus spp., Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli. The usage of prophylactic antibiotics for surgical procedures was high and varied between hospitals. Hospital B had significantly lower concordance to antibiotic therapeutic guidelines, resulting to a higher infection rate, compared with hospital A. ASHP adherence components were then further investigated, after which antibiotic dosing interval and injection time was found to be a significant predictor for positive bacterial growth based on logit–logistic regression. Further interventions and strategies to implement antibiotic stewardship is needed to improve antibiotic prescriptions and their use. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Antibiotic stewardship; Defined daily dose; Hospital; Surgical site infection |
amoxicillin; amoxicillin plus clavulanic acid; ampicillin; antibiotic agent; beta lactamase inhibitor; cefadroxil; cefazolin; cefepime; cefixime; cefoperazone; cefotaxime; cefoxitin; ceftazidime; ceftriaxone; chloramphenicol; ciprofloxacin; clindamycin; cotrimoxazole; fosfomycin; gentamicin; levofloxacin; meropenem; metronidazole; moxifloxacin; norfloxacin; ofloxacin; oxacillin; sulbactam; sultamicillin; tetracycline; vancomycin; adult; aged; antibiotic sensitivity; antimicrobial stewardship; Article; bacterial growth; bacterium culture; drug choice; drug use; Escherichia coli; female; human; infection rate; infection risk; intraoperative period; length of stay; major clinical study; male; medical society; middle aged; observational study; postoperative period; practice guideline; preopera |
MDPI |
14248247 |
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Article |
Q1 |
1295 |
2918 |
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100 |
Irawati Y., Paramita C., Daniel H. |
57201260313;57219380835;57316812600; |
Challenging eyelid reconstruction in malignancies: Case reports |
2021 |
Annals of Medicine and Surgery |
71 |
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102987 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118265765&doi=10.1016%2fj.amsu.2021.102987&partnerID=40&md5=d761c9b6bbfe6b7a5a498e07f9e22253 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Paramita, C., Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Daniel, H., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Eye is one of the most crucial organs in need of protection. The most important function of eyelids is designed to protect the eyeball. Despite their small and thin surface area, they are among the most sunlight-exposed area of skins, hence, it is prone to develop eyelid tumors. As the malignant tumors have the tendency of growing aggressively and have a high mortality, we have to meticulously remove the lesion along with its surrounding tissue, if needed, to ensure the clearance of tumor margin. To strike a suitable outcome between the cosmetic and function after tumor removal is a quite challenging task. Compromise on aesthetics and eyelids’ indispensable function of protecting the eyes during management, may lead to unfavorable cosmetic deformity and loss of vision. Therefore, it is imperative that wise selection of appropriate techniques be discussed and managed accordingly. In this article, the authors reported two case scenarios of eyelid reconstruction which was performed to show the management of full-thickness defect after removal of the malignant neoplasms. Skin flaps and graft technique used to reconstruct the eyelid in each patient was different to emphasize that eyelid malignancies require an individualized management. © 2021 |
Eyelid malignancies; Eyelid reconstruction; Full-thickness defect; Skin flaps; Skin graft |
adult,human; Article; case report; clinical article; ectropion; eyelid cancer; eyelid reconstruction; female; follow up; histopathology; human; human tissue; human,clinical article; keratinocyte; lower eyelid; lymph node biopsy; middle aged; muscle graft; palpation; reconstructive surgery; sentinel lymph node biopsy; skin flap; solid mass; squamous cell carcinoma; telangiectasia; tissue flap |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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102 |
Hamid A.R.A.H., Mochtar C.A., Lisnawati, Saraswati M., Matondang S., Affan M.I.F. |
57202054669;6506558321;24449072000;57208472364;57192085914;57312341900; |
Adenocarcinoma mucinosum of extrophy bladder: A rare case report |
2021 |
International Journal of Surgery Case Reports |
88 |
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106493 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117928866&doi=10.1016%2fj.ijscr.2021.106493&partnerID=40&md5=1f53d31ce0245f1e48544663e50eb793 |
Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia |
Hamid, A.R.A.H., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Mochtar, C.A., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Lisnawati, Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Saraswati, M., Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Matondang, S., Department of Radiology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia; Affan, M.I.F., Department of Urology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Bladder exstrophy is a rare congenital anomaly while, bladder adenocarcinoma mucinous type is a rare type of bladder cancer, with aggressive behavior and inadequate response to radiation and chemotherapy. In extremely rare cases, untreated bladder exstrophy could transform into bladder mucinous adenocarcinoma. Case presentation: We report a case of a 41-year-old male with untreated bladder exstrophy that transformed into mucinous adenocarcinoma. The patient also had epispadias and a right inguinal hernia. Joint procedures were conducted to perform radical cystectomy, total penectomy and W-Pouch continent urostomy, inguinal hernia repair, osteotomy, and keystone and scrotal flap by split-thickness skin graft (STSG) for wound closure. The patient progressed well after surgery, two months after initial procedure, nephrostomies were conducted due to pouches stenosis. Due to the government's limited transportation and lockdown policy, as the Covid-19 pandemic occurred, the patient could not come to the hospital for routine follow-up and died nine-month after surgery. Clinical discussion: Bladder exstrophy is one of the risk factors of bladder cancer. Transformation of bladder exstrophy into mucinous adenocarcinoma is extremely rare, as the case is the first case to be discovered in Indonesia. Surgery, followed with a strict follow-up regime, is mainstay of treatment in this type of malignancy. Conclusion: Adenocarcinoma of mucinous type is a scarce type of bladder exstrophy malignancies. A multidiscipline approach is mandatory in these cases. Strict and regular follow up are suggested for these cases. © 2021 The Authors |
Bladder exstrophy; Epispadias; Inguinal hernia; Mucinous adenocarcinoma |
creatinine; adult; Article; bladder carcinoma; bladder exstrophy; case report; clinical article; colloid carcinoma; coronavirus disease 2019; creatinine blood level; cystectomy; echography; epispadias; excisional biopsy; hernioplasty; histopathology; human; human tissue; hydronephrosis; hydroureter; inguinal hernia; inguinal region; interstitial cystitis; lockdown; male; malignant transformation; multidisciplinary team; nephrostomy; pandemic; pelvis radiography; penis amputation; split thickness skin graft; surgical mortality; wide excision; wound closure; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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103 |
Yolanda S., Maharani K., Imran D., Estiasari R. |
57190854113;57189235094;57203976849;55240204000; |
Intractable singultus as an initial symptom of medulla oblongata tuberculoma: A rare case report |
2021 |
Clinical Neurology and Neurosurgery |
210 |
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106989 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117726468&doi=10.1016%2fj.clineuro.2021.106989&partnerID=40&md5=941f168d079d74939effe24d3444fa1e |
Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Indonesia; Department of Medical Physiology, Faculty of Medicine Universitas Indonesia, Indonesia |
Yolanda, S., Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Indonesia, Department of Medical Physiology, Faculty of Medicine Universitas Indonesia, Indonesia; Maharani, K., Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Indonesia; Imran, D., Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Indonesia; Estiasari, R., Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Indonesia |
Tuberculoma of medulla oblongata is a rare manifestation of central nervous system tuberculosis (CNS TB), which may manifest as intractable singultus as the initial symptom. It is almost impossible to obtain definite diagnosis through biopsy consider its location. Immediate thorough diagnostic workup is needed, and empirical treatment should be started. We report a case of medulla oblongata tuberculoma in an HIV-negative 38-year-old man with intractable singultus as one of the early symptoms. He was treated empirically with anti-tuberculosis therapy and his symptoms subsided within 2 weeks. © 2021 Elsevier B.V. |
Medulla oblongata; Singultus; Tuberculoma |
dexamethasone; ethambutol; isoniazid; pyrazinamide; rifampicin; tuberculostatic agent; tuberculostatic agent; adult; Article; brain cortex; case report; central nervous system tuberculosis; clinical article; coughing; drug withdrawal; fever; gastrointestinal symptom; Glasgow coma scale; headache; hiccup; human; human cell; lung tuberculosis; male; medulla oblongata; mental disease; puncture; tuberculoma; vomiting; complication; diagnostic imaging; hiccup; medulla oblongata; tuberculoma; Adult; Antitubercular Agents; Hiccup; Humans; Male; Medulla Oblongata; Tuberculoma |
Elsevier B.V. |
03038467 |
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34700277 |
Article |
Q2 |
587 |
8611 |
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104 |
Rustamadji P., Wiyarta E., Anggraeni T.D., Siregar T.P. |
55321572200;57221521342;57192894826;57222017915; |
Adult granulosa cell tumor with minor foci of juvenile granulosa cell tumor in postmenopausal woman: A rare case report |
2021 |
International Journal of Surgery Case Reports |
88 |
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106531 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117387663&doi=10.1016%2fj.ijscr.2021.106531&partnerID=40&md5=b928e465d23286856e05bfdba88bbaad |
Department of Pathological Anatomy, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta 10430, Indonesia; Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia |
Rustamadji, P., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta 10430, Indonesia; Anggraeni, T.D., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia; Siregar, T.P., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Central Jakarta, Jakarta 10430, Indonesia |
Introduction: Granulosa cell tumor (GCT) is a rare neoplasm that is divided into adult GCT (AGCT) and juvenile GCT (JGCT). Generally, a patient will only have the AGCT or JGCT subtypes. Here, we presented the first case of AGTC accompanied by focal JGTC in a postmenopausal woman. Presentation of case: A 63-year-old postmenopausal woman came with distended abdomen accompanied by postmenopausal bleeding. CT scan shows a solid mass with cystic degeneration. Laparotomy found a solid mass from the right ovary measuring 18 × 15 × 14 cm. The pathological results showed a diffuse tumor representing AGCT, accompanied by Call-Exner bodies and nuclear groove. In addition, minor foci were also found, which consist of well-defined margins tumor and follicular-like structures that resemble JGCT. The patient underwent bilateral salpingo-oophorectomy with a total hysterectomy and no recurrence in three months follow-up. Discussion: Age and clinical symptoms cannot be used as specific differentiators between AGTC and JGTC. Radiological imaging also shows a similar appearance of solid masses tumors with hemorrhagic or fibrotic changes, multilocular cystic lesions, or completely cystic tumors. The concomitant findings of JGCT and AGCT could be distinguished very carefully by anatomical pathology examination. It is crucial to differentiate AGCT from JGCT, especially to see the prognosis. Conclusion: The role of pathologists is needed in differentiating AGCT and JGCT, primarily when found simultaneously. © 2021 |
Granulosa cell tumor; Menopause; Ovarium tumor; Pathology; Rare case |
abdominal distension; abdominal radiography; adult; adult disease; Article; ascites; bilateral salpingo-oophorectomy; cancer tissue; case report; cell proliferation; clinical article; contrast enhancement; defecation; drug use; echography; female; follow up; frozen section; granulosa cell; granulosa cell tumor; human; hysterectomy; hysteroscopy; inflammatory cell; International Federation of Gynecology and Obstetrics; juvenile granulosa cell tumor; laboratory test; laparotomy; micturition; middle aged; mitosis; mobilization; myometrium; physical examination; postmenopause; postmenopause bleeding; treatment planning; tumor volume; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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106 |
Tobing S.D.A.L., Hendriarto A., Wikanjaya R. |
57192893142;57216821517;57211909508; |
Conservative approach for treatment of Grisel's syndrome after resection of lympahadenitis tuberculosis of the neck: A rare case report |
2021 |
International Journal of Surgery Case Reports |
88 |
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106452 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116936259&doi=10.1016%2fj.ijscr.2021.106452&partnerID=40&md5=a61504c984a695791169d7a4a2464b5f |
Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tobing, S.D.A.L., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hendriarto, A., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wikanjaya, R., Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Grisel's syndrome is a rare condition characterized by nontraumatic rotatory subluxation of the atlantoaxial joint, which was caused by previous inflammation around the head and neck. It is usually seen in children and signed as torticollis. There was no consensus for management, yet early diagnosis and treatment is paramount. Presentation of case: A 5-year-old girl came to outpatient clinic complaining of wry neck 1 day after surgical excision of her TB lymphadenitis and got worsen by time. There was no history of trauma around the neck. Examination under general anesthesia and CT scan revealed acquired severe torticollis consistent with Grisel's Syndrome Fielding type 3 accompanied by TB lymphadenitis, and TB myositis of the neck. Manipulation under general anesthesia and immobilization using Minerva cast followed by Lerman Cervicothoracal Osthosis was conducted. Discussion: This patient was diagnosed with Grisel's syndrome and underwent conservative treatment consisting of reduction under general anesthesia and immobilization using Minerva cast for 6 weeks. The patient was then applied Lherman Cervical Thoracic Orthosis (CTO) halo brace for another 3 months. Anti-tuberculous drug was given to control tuberculous infection. Eight months follow-up showed neither residual deformity, neck pain, nor movement limitation of the neck. Conclusion: Grisel's syndrome has excellent result that is treated with conservative treatment using reduction under general anesthesia and Minerva cast. © 2021 The Authors |
Acquired torticollis; Conservative; Grisel's syndrome; Minerva cast |
cobamamide; cyproheptadine; tuberculostatic agent; Article; atlantoaxial subluxation; body weight gain; case report; cervical lymph node; child; clinical article; computer assisted tomography; conservative treatment; disease exacerbation; excision; excisional biopsy; female; fever; follow up; general anesthesia; Grisel syndrome; headache; histopathology; hoarseness; human; human tissue; immobilization; infection control; interferon gamma release assay; Langhans giant cell; loss of appetite; lymphadenitis; myositis; nausea; neck malformation; neuroimaging; night sweat; nuclear magnetic resonance imaging; outpatient department; physical examination; preschool child; puncture; range of motion; sternocleidomastoid muscle; torticollis; tuberculin test; tuberculous lymphadenitis |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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