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282 |
Lazarus G., Wangsaputra V.K., Christianto, Louisa M., Soetikno V., Hamers R.L. |
57214599425;57215576000;57223348000;41461551400;36769252100;23034345900; |
Safety and Pharmacokinetic Profiles of Long-Acting Injectable Antiretroviral Drugs for HIV-1 Pre-Exposure Prophylaxis: A Systematic Review and Meta-analysis of Randomized Trials |
2021 |
Frontiers in Pharmacology |
12 |
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664875 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111311631&doi=10.3389%2ffphar.2021.664875&partnerID=40&md5=708eaf175b9ad89a98ff6679c222f1c7 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wangsaputra, V.K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Christianto, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Objectives: To investigate the safety and pharmacokinetic profiles of long-acting injectable pre-exposure prophylaxis (LAI PrEP), notably cabotegravir (CAB-LA) and rilpivirine (RPV-LA), for the prevention of human immunodeficiency virus-1 (HIV-1) infection. Methods: Eligible randomized trials of LAI PrEP in HIV-uninfected and/or healthy patients were included and assessed with the Revised Cochrane risk-of-bias tool for randomized trials. Where feasible, a meta-analysis was performed for safety outcomes by using a random-effects model with risk ratios and their 95% confidence intervals as the common effect measure. The protocol was registered with PROSPERO CRD42020154772. Results: Eight studies cumulating a total of 666 participants were included in this systematic review, including five (362 intervention-arm volunteers) and four trials (194 intervention-arm volunteers) that investigated CAB-LA and RPV-LA, respectively. We found that both CAB-LA and RPV-LA were generally well-tolerated as their safety profiles were similar to placebo in terms of any adverse event (AE), serious AE, and AE-related withdrawals. Furthermore, pharmacokinetic analyses revealed favorable prospects in viral inhibitory activity of CAB-LA and RPV-LA. Intramuscular (IM) injection of CAB-LA 600 mg Q8W was superior to CAB-LA 800 mg Q12W in male participants, while the same was true for RPV-LA 1200 mg IM Q8W over other dosing regimens. Although these results are promising, further research is required to confirm the findings on RPV-LA as current evidence is limited. Conclusion: CAB-LA and RPV-LA have promising safety and pharmacokinetic profiles. The preventive efficacy of these agents is being evaluated in Phase 3 trials. © Copyright © 2021 Lazarus, Wangsaputra, Christianto, Louisa, Soetikno and Hamers. |
cabotegravir; HIV-human immunodeficiency virus; long acting injectable (LAI); pre-exposure (PrEP) prophylaxis; rilpivirine |
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Frontiers Media S.A. |
16639812 |
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Review |
Q1 |
1384 |
2619 |
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310 |
Situmorang H., Hestiantoro A., Purbadi S., Flamandita D., Sahlan M. |
57195939562;8743255100;6505677307;57216766308;57189182661; |
IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor |
2021 |
Annals of Medicine and Surgery |
67 |
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102459 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109547312&doi=10.1016%2fj.amsu.2021.102459&partnerID=40&md5=0f7d6fdeda084de97c22a80f60f7b2a7 |
Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Situmorang, H., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Purbadi, S., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Flamandita, D., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia; Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Introduction: Endometriosis is a disease that impacts around 10% of all women in reproductive age, with pelvic pain and infertility as its main clinical features. Current medical treatment targeting lowering estrogen activity has not shown sufficient result due its side effects and reproductive function suppression. Propolis has been widely studied, showing anti inflammation and pro-apoptosis property, that could potentially be used in the treatment of endometriosis. This study investigates the interaction between Sulawesi Propolis’ active components and receptors and protein related to endometriosis pathogenesis. Methods: Active components of Sulawesi Propolis were initially identified with their targeted protein receptors. Lipinski rules were used to screen potential components. The ligands and proteins were tested using Autodock program to predict the most active compound and possible binding sites between propolis and some target proteins associated with inflammatory and apoptotic activity in endometriosis models. Receptor modelling is then performed using Swiss-Model. Results: These active components of Sulawesi Propolis showed a strong binding potential towards TNF- α, NF-kb, Estrogen-α, Estrogen-β, progesterone B, PGE2 EP2 and EP3 subtype respectively: Sanggenon C, Sanggenon H, Epicryptoacetalide, Chrysin-7-O-β-D-glucopyranodside, Irilone, Polydatin and Epicryptoacetalide. Compared to its negative ligand, Sulawesi Propolis displayed a stronger binding capacity to TNF-α, Estrogen-α, and Progesterone B receptors. Conclusion: Sulawesi Propolis has the ability to interact with receptors related to reproductive function, apoptotic reactions and inflammatory processes, a significant factor associated with the pathogenesis of endometriosis. © 2021 |
Docking; Endometriosis; Estrogen receptor; In silico; NF-kB; Progesterone receptor; Propolis; Prostaglandin receptor; TNF alpha Receptor |
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Elsevier Ltd |
20490801 |
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Article |
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391 |
12334 |
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312 |
Mantiri B.J., Sigumonrong Y. |
57211646737;57209291346; |
Bilateral adrenal tumor: A case report and current challenges |
2021 |
International Journal of Surgery Case Reports |
84 |
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106134 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109442036&doi=10.1016%2fj.ijscr.2021.106134&partnerID=40&md5=6e73ca95877115564bd2d8829933ec42 |
Urology Resident of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia; Urology Consultant of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia |
Mantiri, B.J., Urology Resident of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia; Sigumonrong, Y., Urology Consultant of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia |
Introduction: A bilateral adrenal tumor is a rare case. It differs significantly from unilateral adrenal mass since it is related strongly to genetic and family history. Adrenocortical Carcinoma might cause related hormonal syndromes such as Cushing syndrome, Conn syndrome, and virilization. Aim: This study aims to report an uncommon presentation of a 15-year-old female with bilateral Adrenal Tumor since an early age with virilization as the main symptoms. Case presentation: The patient is a 15-year-old girl with female genitalia presentation. She complained of a bulging mass on her right flank with pain four years ago. The mass size grew progressively and initially painless. However, the patient started to feel pain a year ago. Since she was six years old, the mass started to appear on the left flank, and then it also started to appear on the right side. The mass appearance is simultaneous with virilization symptom development, such as the emergence of facial hair, mustache, and sideburns. In 2020, MRI showed a lesion on the right suprarenal with contrast enhancement with 14.5 × 11.5 cm in size, and a 5.6 × 4 cm recurrent left suprarenal lesion. The patient underwent right adrenalectomy resection surgery on January 21st, 2021. The immunohistochemistry examination suggested Adrenocortical Carcinoma. Conclusion: Adrenocortical Carcinoma is a hormone-secreting tumor that might affect the patient's condition systematically. Neglected cases of adrenal cortical carcinoma might affect secondary sexual organ development in the long term. Thus, an early diagnosis and treatment are paramount for this case. © 2021 |
Adrenalectomy; Bilateral adrenocortical carcinoma; Virilization |
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Elsevier Ltd |
22102612 |
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Article |
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232 |
17549 |
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313 |
Rahayatri T.H., Amaliah R., Putri N.M., Puspaningtyas N.W., Karyanti M.R., Hendarto A. |
57188549965;57224001785;57192904294;57223288515;56290680800;57204142249; |
Omphalopagus conjoined twins separation during coronavirus disease-19 pandemic era: A case report |
2021 |
International Journal of Surgery Case Reports |
84 |
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106150 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109424878&doi=10.1016%2fj.ijscr.2021.106150&partnerID=40&md5=a376a2af0ee2eeb9a9da557e67166686 |
Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Plastic Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Intensive Care Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Infectious and Tropical Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Nutrition and Metabolic Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rahayatri, T.H., Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Amaliah, R., Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putri, N.M., Faculty of Medicine, Universitas Indonesia, Plastic Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Puspaningtyas, N.W., Faculty of Medicine, Universitas Indonesia, Pediatric Intensive Care Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karyanti, M.R., Faculty of Medicine, Universitas Indonesia, Pediatric Infectious and Tropical Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hendarto, A., Faculty of Medicine, Universitas Indonesia, Pediatric Nutrition and Metabolic Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Conjoined twin is a rare congenital anomaly characterized by a fusion of certain anatomical structures. Coronavirus-19 (COVID-19) is a new emerging infectious respiratory disease affecting worldwide and potentially leads to acute respiratory distress (ARDS) in children. COVID-19 has reconstructed the healthcare system, including surgical care and decision-making. Case presentation: Herein we describe a surgical separation of 2.5 months old omphalopagus conjoined twins, with one of them (Baby A) presenting COVID-19-associated respiratory distress, as well as the challenges faced during the preparation and the execution of the complex surgical procedure. Clinical discussion: Baby A underwent antiviral therapy, oxygen supplementation, and ventilation in the ICU, while baby B remained stable and confirmed negative for SARS-CoV-2. The separation surgery was conducted after baby A had become clinically stable. Defect closure and reconstruction were accomplished. At one week follow-up, Baby A died of lung infection, while baby B remained well after one year. Conclusion: The complexity of surgical separation requires careful planning by a multidisciplinary team. Surgical separation of conjoined twins during the pandemic era has not been reported much in the literature, more reports are required to provide further insight. © 2021 The Authors |
Case report; Children; Conjoined twins separation; COVID-19; Omphalopagus conjoined twins |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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314 |
Kreshanti P., Putri N.T., Martin V.J., Sukasah C.L. |
36192866200;57192904294;57221635093;57218391534; |
The effectiveness of oral propranolol for infantile hemangioma on the head and neck region: A case series |
2021 |
International Journal of Surgery Case Reports |
84 |
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106120 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109354279&doi=10.1016%2fj.ijscr.2021.106120&partnerID=40&md5=d7e0ac8c9d5ad4046f2b8c78dc622412 |
Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kreshanti, P., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.T., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Martin, V.J., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sukasah, C.L., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Infantile hemangioma is the most common tumor in infancy, with 60% occurring on the face and neck. A large tumor involving the facial region will cause significant aesthetic and functional impairment and isn't always easy to treat surgically. A non-invasive treatment is needed for this condition. Propranolol has recently been used as a choice of treatment in infantile hemangioma. Presentation of case: We presented two cases of large problematic infantile hemangioma that were successfully managed with oral propranolol. Discussion: Large problematic lesions that ulcerate and bleed often need surgery; however, a substantial defect resulting from surgery is tricky to reconstruct and can cause significant scar. Propranolol is used because of its efficacy and low risk characteristics. Conclusion: Propranolol is an effective treatment to reduce the need of surgical intervention in problematic hemangioma. © 2021 The Authors |
Case report; Infantile hemangioma; Propranolol; Surgery |
eye ointment; gentamicin; propranolol; blood pressure monitoring; capillary hemangioma; case report; cheek; child; clinical article; clinical effectiveness; clinical feature; dermatologist; drug dose increase; drug efficacy; ecchymosis; eye protection; eyelid; female; head and neck disease; heart rate measurement; human; lung function test; male; neoplasm; ophthalmologist; palpation; patient referral; preschool child; risk; Short Survey; skin color; skin ulcer; tumor volume |
Elsevier Ltd |
22102612 |
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Short Survey |
Q3 |
232 |
17549 |
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316 |
Widodo D.W., Dewi D.J., Ranakusuma R.W., Irawati Y. |
56644646600;57219323765;57189729404;57201260313; |
Evaluation of 3 and 2-point internal fixation in the management of zygomaticomaxillary complex fractures: Case report |
2021 |
Annals of Medicine and Surgery |
67 |
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102539 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109176909&doi=10.1016%2fj.amsu.2021.102539&partnerID=40&md5=aa5581548a2394f973a5958f289f0999 |
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Widodo, D.W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dewi, D.J., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ranakusuma, R.W., Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Irawati, Y., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: The ZMC has a prominent shape compared to other parts in the midfacial region, thus small injuries will generate fractures in the ZMC. The management of ZMC fracture depends on the fracture deformity and the surgeon's considerations. Various studies have revealed the success of ZMC reconstruction with one fixation point to 4 fixation points fitting to the tetrapod shape. Case report: We report two cases of ZMC fractures which comparing the efficacy of 3- and 2-point internal fixations for improving clinical outcomes The first patient underwent ORIF which placed at 2 fixation points, the first point in the left ZF suture and the second point in the left ZMB. The second patient underwent ORIF reconstruction at 3 fixation points, the first point in the right inferior orbital rim, the second point in the right ZF suture, and the third point in the right ZMB. Discussion: The most common surgical approach for ZMC fractures is through a gingivobuccal groin incision. This approach is for body exposure of the ZMB, which is the main buttress. The 3-point internal fixation improved the postoperative clinical outcome of fracture fragment stability compared to two-point fixation, but the mean malar height projection, vertical dystopia, and enophthalmos were not different between the two fixation methods. Conclusion: Three-point internal fixation can improve the clinical outcome of fracture fragment stability compared to 2-point fixation; however, it has a mean operative duration 22.2 minutes longer than 2-point fixation, so its application must be considered during the COVID-19 pandemic. © 2021 The Authors |
Case report; Internal fixation; Zygomatic fracture; Zygomaticomaxillary fracture |
adult; Article; cartilage graft; case report; clinical article; comparative effectiveness; computer assisted tomography; coronavirus disease 2019; endotracheal intubation; enophthalmos; female; general anesthesia; heterotopia; human; inguinal region; maxilla fracture; maxillofacial surgery; nose cavity; open fracture reduction; osteosynthesis; pandemic; physical examination; visual acuity; zygoma arch fracture |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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317 |
Hutauruk S.M., Hermani B., Monasari P. |
57205105620;14325051100;57224812004; |
Role of chlorhexidine on tracheostomy cannula decontamination in relation to the growth of Biofilm-Forming Bacteria Colony- a randomized controlled trial study |
2021 |
Annals of Medicine and Surgery |
67 |
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102491 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108345034&doi=10.1016%2fj.amsu.2021.102491&partnerID=40&md5=a3d916bc24eff149d6342e51ea55083d |
ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Hutauruk, S.M., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Hermani, B., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Monasari, P., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Background: Regular cleaning of the cannula in the trachea is very important for infection prevention. How to wash the tracheal cannula which is good to reduce the possibility of colonies of biofilm-forming bacteria and the growth of bacterial and the pattern of bacterial on the tracheal cannula is still unknown. This study aims to evaluate the efficacy of decontamination of the tracheal cannula using chlorhexidine and NaCl 0.9% in patients using the tracheal cannula to decrease biofilm-forming bacterial colony. Methods: 40 subjects were grouped into 20 subjects in the control group washing the cannula using 0.9% NaCl and the interventional group washing cannula using and with 2.5% chlorhexidine solution and 0.9% NaCl. This study used a parallel randomized controlled trial of 2 groups with a single blinded. Results: 40 subjects studied, 17 subjects (85%) each group produced biofilm-forming bacteria prior to intervention. After intervention in the study group, 15 subjects were biofilm negative and 5 biofilm positive subjects p = 0.001. The most common bacteria found in the control group is Pseudomonas aeruginosa, while in the study group some bacteria such as Acinetobacter sp. and Proteus mirabilis. Amoxicilin-Clavulanate had the highest resistance to biofilm forming bacteria in both groups. Piperacillin, ceftazidime, ciprofloxacin and meropenem have the highest sensitivity to biofilm-forming bacteria. Conclusion: There was a significant decrease in the number of colonies that produced biofilm in the tracheal cannula in the study group compared to the control group in tracheal cannula washing. © 2021 The Authors |
Bacteria colony; Biofilms; Chlorhexidine; Tracheostomy cannulae |
amoxicillin plus clavulanic acid; ceftazidime; chlorhexidine; ciprofloxacin; meropenem; piperacillin; sultamicillin; adult; aged; antibacterial activity; antibiotic resistance; Article; bacterial growth; bacterium colony; biofilm; clinical article; controlled study; decontamination; diabetes mellitus; Escherichia coli; human; hypertension; malnutrition; Proteus mirabilis; Pseudomonas aeruginosa; randomized controlled trial; single blind procedure; Staphylococcus aureus; tracheostomy |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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318 |
Hafizar, Hamid A.R.A.H., Saraswati M. |
57224823578;57202054669;57208472364; |
Cystoscopy-assisted laparoscopic partial cystectomy for muscle-invasive bladder cancer: Initial experience in Cipto Mangunkusumo Hospital, Jakarta |
2021 |
International Journal of Surgery Case Reports |
84 |
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106083 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108324475&doi=10.1016%2fj.ijscr.2021.106083&partnerID=40&md5=5cb1198507ed3b79541fd99fb1fe97d8 |
Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Hafizar, Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hamid, A.R.A.H., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saraswati, M., Department of Anatomical Pathology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: We report the experience with patients of urachal adenocarcinoma of the bladder, a rare malignancy in the urinary bladder, treated with laparoscopic partial cystectomy. Aim: Solitary transitional cell carcinoma (TCC) of the dome/anterior wall of the bladder in some cases. As compared to radical surgery, partial cystectomy has a lower morbidity rate and similar oncological outcomes. We present our experience with laparoscopic partial cystectomy (LPC) in patients with urachal adenocarcinoma. Case presentation: Until being admitted to the hospital, a 60-year-old woman had been suffering from painless, sporadic gross hematuria for the previous year. Her physical examination was undistinguished. Computed tomography revealed an enhancing firmly bordered mass on the anterior-superior aspect of the bladder wall. The patient then underwent cystoscopy and laparoscopic partial cystectomy simultaneously. Conclusion: Based on our first experience in LPC, we suggest that cystoscopy assisted LPC is a reasonable and safe procedure with fewer complications and does not extend the operating time. The procedure's effectiveness hinges on the patient's selection. However, many cases needed to emphasize the effectiveness and safety of LPC. © 2021 The Authors |
Bladder cancer; Cystoscopy; Laparoscopy |
cisplatin; doxorubicin; gemcitabine; abdominal radiography; adenocarcinoma; adjuvant chemotherapy; adult; Article; bladder tumor; bladder wall; bleeding; cancer chemotherapy; cancer patient; cancer surgery; case report; clinical article; colloid carcinoma; computer assisted tomography; cystectomy; cystography; cystoscopy; differential diagnosis; echography; female; general anesthesia; hematuria; histopathology; human; human tissue; laparoscopic surgery; lithotomy; lower abdominal pain; medical history; middle aged; multiple cycle treatment; muscle invasive bladder cancer; transitional cell carcinoma; urachus |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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319 |
Oesman I., Sari C.M. |
57203961169;57224515809; |
Neglected neurogenic clubfoot treated with Achilles tendon lengthening using Z-plasty, total talectomy, and tibiocalcaneal arthrodesis |
2021 |
International Journal of Surgery Case Reports |
84 |
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106051 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107734709&doi=10.1016%2fj.ijscr.2021.106051&partnerID=40&md5=551520e63137809a0d35da15c3df6ec0 |
Foot and Ankle Consultant, Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Oesman, I., Foot and Ankle Consultant, Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Sari, C.M., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Introduction: The most common foot and ankle deformity from injury to the nervous system is equinocavovarus. This deformity comprises of equinus, cavus, varus, and adduction of the forefoot which leads to pain and poor stability in stance phase of gait. Treatment for this condition is difficult regarding literature limitation of the neurogenic clubfoot management. We reported a 18-year-old female with neglected right neurogenic clubfoot treated with 2 stage deformity correction. Case report: A 18-year-old female presented with crooked right foot since birth. It caused pain, especially during walking and standing for a long time and resulted in occasional skin infection on the bottom of the foot. However, currently she could walk in limping gait without walking aid. The patient was born aterm 39 weeks through caesarean delivery due to severe preeclampsia. There was delayed development of walking at 2 years and 9 months. Previously, she had history of spina bifida and undergone surgery in 2001. Afterward, she underwent VP shunt surgery. Physical examination demonstrated cavus varus, tenderness of the right foot, and limited ankle motion. The patient was diagnosed with neglected right neurogenic clubfoot and underwent two stage deformity correction consisting of Achilles tendon lengthening using Z-plasty, total talectomy, and tibiocalcaneal arthrodesis followed by posteromedial release, tendon lengthening (Tibialis posterior, FDL, FDB) and plantar fascia release. Conclusions: Two stage deformity correction can be successful in patients with neglected neurogenic clubfoot. Further studies are required to investigate the safety and efficacy of such procedure in neurogenic clubfoot. © 2021 The Authors |
Achilles tendon lengthening; Neurogenic clubfoot; Tibiocalcaneal arthrodesis; Total talectomy |
cefoperazone plus sulbactam; polypropylene; achilles tendon; adult; arthrodesis; Article; bone graft; calcaneus; case report; clinical article; clubfoot; deformity; female; fibrosis; follow up; general anesthesia; human; limp (gait); motor development; neurologic disease; osteotomy; pain; physical examination; postoperative period; preoperative period; preoperative treatment; skin infection; spinal dysraphism; standing; surgical technique; talectomy; tibia; walking; X ray; young adult; Z plasty |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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320 |
Priyatini T., Roziana |
57192265423;57218684529; |
Modified Passerini-Glazel feminizing genitoplasty outcomes in adults: Two rare cases |
2021 |
International Journal of Surgery Case Reports |
84 |
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106086 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107634308&doi=10.1016%2fj.ijscr.2021.106086&partnerID=40&md5=1f174f5a5decf1024dcb84cf6d7d80f7 |
Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Priyatini, T., Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Roziana, Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Modified Passerini-Glazel feminizing genitoplasty is typically performed in children with atypical genitalia. In our article, we have performed the procedure in adults with genital anomalies. Case presentation: The first case was a 22 years old woman who was planning to get married. She presented with a chief complaint of having no vaginal canal. Gynecological examination showed no vaginal opening. The common channel was visible, and the size of the perineal body was 3 cm. The patient underwent vaginal reconstruction using a modified Passerini-Glazel technique without amnion graft. The second case was a 20 years old girl planning to get married, with a chief complaint of small vaginal introitus. Gynecology examination showed small minor labia with an introitus size of 1 cm. The patients underwent vaginal reconstruction and labioplasty using a modified Passerini-Glazel technique with an amnion graft. Both patients have undergone anal atresia surgery in childhood. Discussion: There was no difference in outcome between using amnion graft and without amnion graft following the modified Passerini-Glazel feminizing genitoplasty procedure. The first patient had been pregnant and had successful delivery by elective cesarean section. Moreover, the second patient had no complaint of sexual disorders after the procedure. No cases of dysuria, urinary tract infection, leukorrhea, hematocolpos, or malodorous vaginal discharge were reported in both cases. Conclusion: Modified Passerini-Glazel feminizing genitoplasty is a safe and effective procedure. Daily vaginal dilation in the postoperative period was unnecessary, and it allowed for an excellent cosmetic result. © 2021 The Authors |
Genitalia anomaly; Good outcome; Modified Passerini-Glazel feminizing genitoplasty |
polyglycolic acid; adult; amnion; anal mucosa; anus atresia; anus injury; anus surgery; bulbocavernosus muscle; case report; cesarean section; clinical article; clinical outcome; echography; female; follow up; gynecological examination; hematocolpos; high school graduate; human; hydrosalpinx; hysteroscopy; incision; labia minora; menstrual irregularity; menstruation; micturition; modified Passerini-Glazel feminizing genitoplasty; palpation; postoperative period; pregnancy; reconstructive surgery; scar; sexual dysfunction; sexual function; sexual intercourse; Short Survey; surgical technique; suture technique; tissue graft; unemployment; urine color; urogenital tract malformation; urologic surgery; uterus malformation; vagina; vagina aplasia; vagina mucosa; vaginoscopy; young adult |
Elsevier Ltd |
22102612 |
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Short Survey |
Q3 |
232 |
17549 |
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