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Wahidiyat P.A., Yo E.C., Wildani M.M., Triatmono V.R., Yosia M. |
24400464000;57213188908;57223404540;57225083843;57204933098; |
Cross-sectional study on knowledge, attitude and practice towards thalassaemia among Indonesian youth |
2021 |
BMJ Open |
11 |
12 |
e054736 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121204786&doi=10.1136%2fbmjopen-2021-054736&partnerID=40&md5=254c5b647a17fbed23378ced6a556eb2 |
Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Hematology and Oncology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wahidiyat, P.A., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Hematology and Oncology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia; Yo, E.C., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wildani, M.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Triatmono, V.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction Thalassaemia is an inherited blood disorder, for which definitive treatments remain largely inaccessible. The recommended approach to reduce the disease burden is by prevention through screening. Currently, the implementation of thalassaemia preventive measures is poorly regulated in Indonesia. Thalassaemia prevention and education are best targeted to the youth, but information on their awareness towards thalassaemia is limited. This study aims to investigate the knowledge, attitude and practice (KAP) towards thalassaemia among Indonesian youth. Methods This observational study took place between January and May 2021. An online questionnaire was disseminated to Indonesian youth aged 15-24. Eligible respondents included carriers, unaffected individuals and individuals with unknown carrier status. The questionnaire comprised 28 questions to assess KAP. A cut-off of 75% was used to categorise participant's KAP into poor or negative and good or positive. Descriptive statistics, χ 2 test, logistic regression and Pearson correlation were performed for data analysis. Results A total of 906 responses were gathered, and 878 were analysed. Most respondents had poor knowledge (62.1%), positive attitude (83.3%) and poor practice (54.4%) towards thalassaemia. The results implied that respondents had limited understanding regarding the types of thalassaemia and the difference between asymptomatic carriers and individuals without the thalassaemia trait. Many (82.6%) believed they were not carrying thalassaemia trait despite the fact that most (95.7%) never got tested. Age, education, gender, residence and family income were key factors that correlated with or predicted the youth's KAP towards thalassaemia. Older respondents and women were more likely to have good KAP. Conclusion Thalassaemia screening targeted to the youth is urgently needed, and future interventions must consider sociodemographic factors that may affect how they perceive the disease. Social media appeals to the youth as an important source of information, but school, parents and health professionals should also be involved in delivering education about thalassaemia. © BMJ Publishing Group Limited 2021. |
community child health; haematology; paediatrics; public health |
adolescent; adult; age distribution; Article; asymptomatic carrier; attitude to health; bone marrow transplantation; child health; controlled study; cross-sectional study; demography; educational status; family income; female; gene therapy; human; Indonesia; juvenile; leukemia; major clinical study; male; observational study; questionnaire; screening test; self concept; sex difference; thalassemia; thalassemia major |
BMJ Publishing Group |
20446055 |
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34862299 |
Article |
Q1 |
1132 |
3624 |
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10 |
Lee Y.-S., Oh Y.S., Choi E.-K., Chern A.K.C., Jiampo P., Chutinet A., Hanafy D.A., Trivedi P., Zhai D. |
57369401600;14021940000;35558194200;57219941181;57219936937;15724336700;55431326800;57219936294;57219941292; |
Patient perception and treatment convenience of dabigatran versus vitamin K antagonist when used for stroke prophylaxis in atrial fibrillation: Real-world Evaluation of Long-term Anticoagulant Treatment Experience (RE-LATE) study |
2021 |
Open Heart |
8 |
2 |
e001745 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121029837&doi=10.1136%2fopenhrt-2021-001745&partnerID=40&md5=604033aab18ff9417453572cb72e2905 |
Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea; Department of Internal Medicine, Catholic University of Korea, Seoul, South Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Department of Cardiology, Columbia Asia Hospital, Taiping, Malaysia; Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand; Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Division of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; Cardiology and Vascular Medicine, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Cardiology and Vascular Medicine, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States |
Lee, Y.-S., Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea; Oh, Y.S., Department of Internal Medicine, Catholic University of Korea, Seoul, South Korea; Choi, E.-K., Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Chern, A.K.C., Department of Cardiology, Columbia Asia Hospital, Taiping, Malaysia; Jiampo, P., Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand; Chutinet, A., Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, Division of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; Hanafy, D.A., Cardiology and Vascular Medicine, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia, Cardiology and Vascular Medicine, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Trivedi, P., Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore; Zhai, D., Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States |
Purpose Dabigatran is a direct thrombin inhibitor approved for stroke prophylaxis in patients with non-valvular atrial fibrillation (NVAF). Real-world data about patient preference, satisfaction and convenience in patients in Asia are not available. The study aimed to explore the perception of patients with newly diagnosed NVAF regarding dabigatran versus vitamin K antagonists (VKAs), when used for stroke prevention. Patients and methods This was a multinational, multicentre, non-interventional study involving 49 sites across 5 countries in South East Asia and South Korea where 934 patients newly diagnosed with NVAF were initiated on either dabigatran (N=591) or VKA (N=343). Data were collected at baseline and over two follow-up visits across 6 months. Treatment satisfaction and patient convenience were evaluated using the Perception on Anticoagulant Treatment Questionnaire-2 (PACT-Q2). Results The mean age of the patients was 65.9±10.4 years, and 64.2% were male. Mean CHA 2 DS 2-VASc score was 2.4±1.5, and mean HAS-BLED score was 1.2±0.9. At baseline, patients initiated on dabigatran had higher stroke risk, bleeding risk, creatinine clearance and proportion of patients with concomitant illnesses compared with patients initiated on VKAs. Treatment convenience was perceived to be significantly better with dabigatran versus VKAs at visits 2 and 3 (p=0.0423 and 0.0287, respectively). Treatment satisfaction was significantly better with dabigatran compared with VKAs at visit 3 (p=0.0300). Conclusion In this study, dabigatran is associated with better patient perception in terms of treatment convenience and satisfaction compared with VKAs when used for stroke prevention in newly diagnosed NVAF patients from South East Asia and South Korea. Plain language summary Patient satisfaction with dabigatran versus VKAs in South East Asia. Patients with atrial fibrillation are at high risk of stroke and require anticoagulants for stroke prevention. Two such anticoagulants are dabigatran and VKAs. We wanted to compare the extent of satisfaction and treatment convenience among newly diagnosed patients with atrial fibrillation from the South East Asian region when they were given either dabigatran or VKAs. Consenting patients filled out a standardised questionnaire called the PACT-Q2 over three visits after they were started on either dabigatran (591 patients) or VKAs (343 patients). We found that satisfaction and convenience were significantly higher when patients received dabigatran than when they received VKAs. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Atrial fibrillation; Health care; Outcome assessment; Stroke |
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BMJ Publishing Group |
2398595X |
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Article |
Q1 |
1050 |
4080 |
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26 |
Soemantri D., Greviana N., Findyartini A., Azzahra T.B., Suryoadji K.A., Mustika R., Felaza E. |
36640659100;57197709749;56543777300;57223601523;57223633894;57220273147;57217487889; |
"To obey or not to obey" - Medical students' response towards professional dilemmas in a hierarchical and collectivist culture |
2021 |
PLoS ONE |
16 |
12 December |
e0261828 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122028276&doi=10.1371%2fjournal.pone.0261828&partnerID=40&md5=379871263550acde1f1182540ba60243 |
Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia |
Soemantri, D., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Findyartini, A., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Azzahra, T.B., Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia; Suryoadji, K.A., Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Felaza, E., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia |
Background Clinical clerkship programme in medical schools were developed to provide students with direct interactions with patients and observe clinical teachers in practice. However, professional dilemmas are prone to occur due to the nature of experiential learning. Several studies across different cultures showed that medical students responded differently towards professional dilemma. Aims This study aims to explore how medical students respond to professional dilemmas occurred during their clinical clerkships and to what extent culture influences the responses. Method A qualitative descriptive approach was used in this study. We conducted four focus group discussions with final year medical students who were selected using maximum variety sampling method. Thematic analysis was conducted following the transcription of the focus groups. Results We identified the impact of dilemmas on students' emotions and concerns, students' responses towards professional dilemmas, and factors affecting responses to dilemmas in clinical clerkship, which confirmed that cultures played roles in how students responded towards professional dilemmas. Conclusion This study has identified that culture, to some extent, influenced the way students responded to professional dilemmas. Therefore, it is paramount to develop a conducive and culturally sensitive educational environment and students' ability to learn from professional dilemma experienced in the workplace for developing their professional identity. © 2021 Soemantri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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article; clinical education; emotion; genetic transcription; human; human experiment; medical student; thematic analysis; workplace; clinical trial; emotion; female; male; medical school; problem based learning; Emotions; Female; Humans; Male; Problem-Based Learning; Schools, Medical; Students, Medical |
Public Library of Science |
19326203 |
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34941959 |
Article |
Q1 |
990 |
4434 |
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27 |
Koesnoe S., Masjkuri N., Adisasmita A., Djauzi S., Kartasasmita C., Sundoro J., Nadjib M., Korib M., Muthia A.N., Muzellina V.N., Habibah U., Nursyirwan S.A., Djaya K.H., Bachtiar N.S., Sari R.M. |
26028015000;57189271669;22978283200;23495847800;57206248946;49762130000;24401623600;57391576000;57391576100;57223968527;57391443900;57249143800;57392218600;54879388400;57191341371; |
A randomized controlled trial to evaluate the effect of influenza vaccination and probiotic supplementation on immune response and incidence of influenza-like illness in an elderly population in Indonesia |
2021 |
PLoS ONE |
16 |
12 December |
e0250234 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122024701&doi=10.1371%2fjournal.pone.0250234&partnerID=40&md5=6918933f17507c8ed64013b241adb3c2 |
Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Indonesian Society of Internal Medicine, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; PT. Bio Farma, Bandung, Indonesia |
Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Masjkuri, N., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Adisasmita, A., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Djauzi, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Kartasasmita, C., Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Sundoro, J., Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Nadjib, M., Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Korib, M., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Muthia, A.N., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Muzellina, V.N., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Habibah, U., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Djaya, K.H., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Bachtiar, N.S., PT. Bio Farma, Bandung, Indonesia; Sari, R.M., PT. Bio Farma, Bandung, Indonesia |
Aim To investigate the effect of influenza vaccination with or without probiotic supplementation on the immune response and incidence of influenza-like illness (ILI) in the elderly. Methods A randomized double-blind, placebo-controlled trial with a modified factorial design was conducted in 554 healthy elderly subjects aged 67 ± 5.6 (ranging from 60–90) years old in the Primary Health Care Center (Puskesmas area) of the Pulo Gadung District East Jakarta. Subjects received either a trivalent influenza vaccine or placebo at the start of the study, and a probiotic supplement (Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011) or a placebo for 6 months. Subjects were randomly assigned into four intervention groups: influenza vaccine and probiotics (n = 141), influenza vaccine and placebo (n = 136), placebo and probiotics (n = 140), and both placebo (n = 137). The primary outcome was ILI incidence within 6 months. The secondary outcomes were seroprotection and seroconversion rates at 1, 4, and 6 months after administering the interventions. Results This study showed that the trivalent influenza vaccine increased seroprotection (RR 3.6 [95%CI 2.92–4.47]; p<0.010) and seroconversion (RR 29.8 [95%CI 11.1–79.5]; p<0.010) rates 1 month after vaccination in elderly people while the probiotic supplement did not alter influenza antibody titers (p = 1.000 and p = 0.210). The relative ILI incidence risk was similar between vaccinated and non-vaccinated groups, as well as in the probiotic group compared to the non-probiotic group. Conclusion The tested trivalent influenza vaccine significantly induced seroprotection and seroconversion in the vaccinated subjects, while probiotics administration did not influence these parameters. Vaccinated individuals displayed a similarly low ILI incidence as those in the Control Group. However, the observed trend towards a reduction of ILI incidence with probiotics supplementation warrants further assessments in a larger, at-risk population. © 2021 Koesnoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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flubio; influenza vaccine; placebo; influenza vaccine; probiotic agent; adult; aged; antibody titer; Article; controlled study; diet supplementation; double blind procedure; drug effect; female; human; immune response; incidence; Indonesia; influenza; major clinical study; male; middle aged; population risk; population structure; primary health care; randomized controlled trial; sample size; seroconversion; treatment duration; treatment outcome; vaccination; very elderly; incidence; influenza; Lactobacillus helveticus; Lactobacillus rhamnosus; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Incidence; Indonesia; Influenza Vaccines; Influenza, Human; Lactobacillus helveticus; Lactobacillus rhamnosus; Male; Middle Aged; Probiotics |
Public Library of Science |
19326203 |
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34914726 |
Article |
Q1 |
990 |
4434 |
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28 |
Lubis A.M., Maruanaya S., Tantri A.R., Pontoh L.A.P., Ifran N.N.P.P.S. |
57391310600;57217187200;57188933853;57192907426;56091403800; |
The Use of Combination Paracetamol and Ibuprofen in Postoperative Pain after Total Knee Arthroplasty, a Randomized Controlled Trial |
2021 |
Pain physician |
24 |
8 |
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E1199 |
E1204 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121993999&partnerID=40&md5=0b79df4a67066c8ba9a1818d9c6e9920 |
Department of Orthopedic & Traumatology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia; Universitas PattimuraMaluku, Indonesia; Department of Anesthesiology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia; Department of Orthopedic, Fatmawati General Hospital, DKI Jakarta, Indonesia; Department of Orthopedic & Traumatology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia |
Lubis, A.M., Department of Orthopedic & Traumatology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia; Maruanaya, S., Universitas PattimuraMaluku, Indonesia; Tantri, A.R., Department of Anesthesiology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia; Pontoh, L.A.P., Department of Orthopedic, Fatmawati General Hospital, DKI Jakarta, Indonesia; Ifran, N.N.P.P.S., Department of Orthopedic & Traumatology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia |
BACKGROUND: Adequate pain management has an important role in supporting early ambulation after total knee arthroplasty (TKA). Multimodal analgesia is one of the modalities of overcoming postoperative pain. The use of a combination of paracetamol and ibuprofen is expected to reduce the total morphine requirement after TKA. OBJECTIVES: The use of a combination of paracetamol and ibuprofen to reduce morphine requirement after TKA, to provide adequate pain management and early ambulation. STUDY DESIGN: Patients scheduled for total knee arthroplasty who met the requirements for inclusion criteria were consented and randomized using randomizer.org in a 1:1:1 ratio to receive either combination paracetamol iv and ibuprofen iv (Group II), paracetamol iv only (Group II), or ibuprofen iv only (III). SETTING: Thirty-six patients aged 63-68 years who underwent TKA were included in this study. METHODS: All patients were divided into 3 groups. Group I received paracetamol 1 g and ibuprofen 800 mg, group II received 1 g paracetamol iv and 100 mL normal saline, group III received 800 mg ibuprofen iv and 100 mL normal saline, 10 minutes before the end of surgery and every 6 hours up to 24 hours. Total morphine consumption, pain score (resting, walking, knee flexion), and 2 minute-length walking tests were measured in hour 24 postoperative. Data were analyzed with SPSS 16.0. RESULTS: Median of total morphine consumption between 3 groups respectively was 7.5 (3.0-36.0) mg vs 15.0 (4.5-28.5) mg vs 9.0 (0.0-24.0) mg with no difference (P = 0.391). Mean of pain score at walking phase respectively was 4.8 ± 0.5 vs 7.3 ± 1.2 vs 5.6 ± 0.5 (hour 24, P < 0.01). Medians of 2-Minute Walking Test respectively were 6.0 (2-16) meters vs 0.0 (0-4) meters vs 0.0 (0-4) meters (hour 24, P < 0.01). LIMITATIONS: The total morphine requirement measured in this study illustrates the consumption of morphine in resting phase. CONCLUSION: The combination of paracetamol and ibuprofen is better in reducing the total morphine requirement after TKA when compared with the administration of paracetamol injection alone or ibuprofen injection alone. Combination paracetamol injection and ibuprofen injection also provides adequate pain management in order to help early ambulation. |
ibuprofen; morphine consumption; pain score; paracetamol; TKA; Multimodal analgesia |
ibuprofen; morphine; narcotic analgesic agent; paracetamol; controlled study; double blind procedure; human; knee replacement; postoperative pain; randomized controlled trial; Acetaminophen; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Double-Blind Method; Humans; Ibuprofen; Morphine; Pain, Postoperative |
NLM (Medline) |
21501149 |
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34793640 |
Article |
Q1 |
1310 |
2852 |
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34 |
Gustiananda M., Sulistyo B.P., Agustriawan D., Andarini S. |
6507570171;57215020738;55382929300;8716259500; |
Immunoinformatics analysis of sars-cov-2 orf1ab polyproteins to identify promiscuous and highly conserved t-cell epitopes to formulate vaccine for indonesia and the world population |
2021 |
Vaccines |
9 |
12 |
1459 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121528747&doi=10.3390%2fvaccines9121459&partnerID=40&md5=e6eaaf1e02bbe5e81bf5d0e390d38566 |
Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jl Persahabatan Raya 1, Jakarta, 13230, Indonesia |
Gustiananda, M., Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Sulistyo, B.P., Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Agustriawan, D., Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jl Persahabatan Raya 1, Jakarta, 13230, Indonesia |
SARS-CoV-2 and its variants caused the COVID-19 pandemic. Vaccines that target conserved regions of SARS-CoV-2 and stimulate protective T-cell responses are important for reducing symptoms and limiting the infection. Seven cytotoxic (CTL) and five helper T-cells (HTL) epitopes from ORF1ab were identified using NetCTLpan and NetMHCIIpan algorithms, respectively. These epitopes were generated from ORF1ab regions that are evolutionary stable as reflected by zero Shannon’s entropy and are presented by 56 human leukocyte antigen (HLA) Class I and 22 HLA Class II, ensuring good coverage for the Indonesian and world population. Having fulfilled other criteria such as immunogenicity, IFNγ inducing ability, and non-homology to human and microbiome peptides, the epitopes were assembled into a vaccine construct (VC) together with β-defensin as adjuvant and appropriate linkers. The VC was shown to have good physicochemical characteristics and capability of inducing CTL as well as HTL responses, which stem from the engagement of the vaccine with toll-like receptor 4 (TLR4) as revealed by docking simulations. The most promiscuous peptide899WSMATYYLF907 was shown via docking simulation to interact well with HLA-A*24:07, the most predominant allele in Indonesia. The data presented here will contribute to the in vitro study of T-cell epitope mapping and vaccine design in Indonesia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Cytotoxic T-cells; Helper T-cells; HLA-A*24:07; Human leukocyte antigen; Immunoinformatics; Multi-epitope peptide-based vaccine; SARS-CoV-2; T-cell epitopes |
epitope; gamma interferon; HLA A antigen; HLA antibody; T lymphocyte receptor; toll like receptor 4; allele; allergenicity; amino acid sequence; antigenicity; Article; binding affinity; CD8+ T lymphocyte; controlled study; cytotoxic T lymphocyte; endoplasmic reticulum; entropy; epitope mapping; gene frequency; gene structure; HLA typing; human; human cell; hydrophilicity; immune response; immunogenicity; immunoinformatics; Indonesia; microbiome; molecular docking; open reading frame; peptide synthesis; protein interaction; protein secondary structure; protein structure; sequence alignment; sequence analysis; sequence homology; Severe acute respiratory syndrome coronavirus 2; vaccination |
MDPI |
2076393X |
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Article |
Q1 |
1296 |
2913 |
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36 |
Djusad S., Meutia A.P., Tunggadewi S.A., Sari Y.M., Hakim S., Priyatini T., Moegni F., Santoso B.I. |
57192276788;57203368133;57377695800;57217020003;57192276095;57192265423;55450456100;56653822500; |
Genital self-image as predictor of sexual dysfunction in women with pelvic organ prolapse in Indonesia |
2021 |
Women's Health |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121423948&doi=10.1177%2f17455065211066019&partnerID=40&md5=607bdce156595c4225e7b7fef7a1b89c |
Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia |
Djusad, S., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Meutia, A.P., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Tunggadewi, S.A., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Sari, Y.M., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Hakim, S., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Priyatini, T., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Moegni, F., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Santoso, B.I., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia |
Background: The incidence of sexual dysfunction increases in women with pelvic organ prolapse. In addition to physical factors, other important components that influence each other in sexual dysfunction are psychological aspects and genital self-image. Sociocultural factors also affect individual sexuality and sexual behavior. Until now, there are no data and the relationship between genital self-image and sexual dysfunction in pelvic organ prolapse is not known in Indonesia. Objective: This study aims to analyze the correlation of genital self-image with sexual dysfunction in women with pelvic organ prolapse. Methods: In this cross-sectional study, 113 consecutive women with pelvic organ prolapse were selected in urogynecology referral centers in Jakarta. Demographic data, physical examination, and guided interviews were filled in to complete the Female Sexual Function Index and Female Genital Self-Image Scale-7 questionnaires. Preliminary research has been carried out in the form of language translation and cultural validation of the Indonesian version of the Female Genital Self-Image Scale-7 questionnaires. Results: There is a significant correlation between genital self-image and sexual dysfunction, where the lower Female Genital Self-Image Scale-7 score significantly predicts the lower Female Sexual Function Index score (p < 0.000; odds ratio: 14.17). Conclusion: Genital self-image is the main variable that affects sexual function in women with pelvic organ prolapse. It is necessary to evaluate and treat genital self-image because sexual function is an integrated component of quality of life. © The Author(s) 2021. |
eastern sexuality; Female Genital Self-Image Scale; female sexual dysfunction; Female Sexual Function Index; genital self-image; pelvic organ prolapse |
adult; Article; body mass; cancer staging; constipation; cross-sectional study; cystocele; depression; female; female sexual dysfunction; gynecologic surgery; human; major clinical study; marriage; pelvic examination; pelvic floor disorder; pelvic organ prolapse; psychometry; questionnaire; sexual behavior; sexual dysfunction; sexual function; sleep quality; urinary tract infection; vaginal delivery; genital system; Indonesia; pelvic organ prolapse; psychology; quality of life; Cross-Sectional Studies; Female; Genitalia; Humans; Indonesia; Pelvic Organ Prolapse; Quality of Life; Sexual Behavior; Surveys and Questionnaires |
SAGE Publications Ltd |
17455057 |
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34913375 |
Article |
Q1 |
1363 |
2670 |
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37 |
Tamin S., Adham M., Noer A., Supriana N., Bardosono S. |
57195719598;14024202100;57370851100;8438653200;21933841000; |
Upright epiglottis prevents aspiration in patients with nasopharyngeal carcinoma post-chemoradiation |
2021 |
PLoS ONE |
16 |
12 December |
e0261110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121054797&doi=10.1371%2fjournal.pone.0261110&partnerID=40&md5=c09f68482b8e097a20b06089e0d5849e |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Tamin, S., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adham, M., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Noer, A., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Supriana, N., Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
NPC is the most widely found malignant tumor in the head and neck region in Indonesia. Chemoradiation therapy for NPC can induce swallowing disorders (dysphagia) that adversely affects a patients quality of life. This study aimed to assess the swallowing process by flexible endoscopic evaluation of swallowing in patients with nasopharyngeal carcinoma after chemoradiation. Thirty-nine patients with NPC who had chemoradiation therapy more than one month previously underwent flexible endoscopic evaluation of swallowing and were assessed for oral transport time, sensation, standing-secretion, pre-swallowing leakage, residue, penetration, aspiration, and silent aspiration. The most common structural abnormalities were an upright and swollen epiglottis (89.4%), poor oral hygiene, and velopharyngeal closure defects (56.4%). This examination also revealed a mild degree of standing secretion (38.5%) and aspiration (10.3%). No penetration was observed in 64.1% of the patients, and no silent aspiration was observed in any of the patients. A severe degree of residue (45.7%) was observed when administering oatmeal, while the residue was mild to moderate when administering gastric rice, crackers, and milk. The residue changed to a mild degree (32.3%-51.4%) in all food administrations after the watering maneuver. The highest penetration was noted after oatmeal administration (42.8%), and the highest aspiration was found after milk administration (8.6%). Standing secretion in almost all patients was caused by hyposensitivity of the hypopharynx. Persistent residue and hyposensitivity of the hypopharynx led to aspiration. The low percentage of aspiration and silent aspiration might have been caused by the upright and swollen epiglottis that prevented aspiration. Poor oral hygiene and a dry mouth led to prolonged oral transport. Therefore, most patients had hypopharyngeal abnormalities in the form of a swollen and upright epiglottis. Secretion and food residue were also detected. Drinking helps to expedite the swallowing process by facilitating oral phase transport and reducing residues. © 2021 Tamin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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acid aspiration; adult; adverse event; chemoradiotherapy; digestive tract endoscopy; dysphagia; female; human; male; middle aged; nasopharynx carcinoma; nasopharynx tumor; pathology; pathophysiology; procedures; Adult; Chemoradiotherapy; Deglutition Disorders; Endoscopy, Digestive System; Female; Humans; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Respiratory Aspiration |
Public Library of Science |
19326203 |
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34882745 |
Article |
Q1 |
990 |
4434 |
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39 |
Marofi F., Kozlitina I.A., Margiana R., Bahramali M., Suksatan W., Abdelbasset W.K., Chupradit S., Nasimi M., Maashi M.S. |
57199650994;57428645300;56685900600;57365531600;57219950613;57208873763;57211329338;57189347372;57220613490; |
MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy |
2021 |
Stem Cell Research and Therapy |
12 |
1 |
597 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120732728&doi=10.1186%2fs13287-021-02662-6&partnerID=40&md5=1bb65103a59b38f350d6be8213b4dad8 |
Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Sechenov First Moscow State Medical University, Moscow, Russian Federation; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biotechnology Department, University of Tehran, Tehran, Iran; Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Tehran University of Medical Sciences, Tehran, Iran; Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Kozlitina, I.A., Sechenov First Moscow State Medical University, Moscow, Russian Federation; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bahramali, M., Biotechnology Department, University of Tehran, Tehran, Iran; Suksatan, W., Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Nasimi, M., Tehran University of Medical Sciences, Tehran, Iran; Maashi, M.S., Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regeneration. Further, due to their great potential to stimulate angiogenesis and also facilitate matrix remodeling, MSCs hold substantial potential as future therapeutic strategies in this context. The MSCs-induced wound healing is thought to mainly rely on the secretion of a myriad of paracrine factors in addition to their direct differentiation to skin-resident cells. Besides, MSCs-derived exosomes as nanoscale and closed membrane vesicles have recently been suggested as an effective and cell-free approach to support skin regeneration, circumventing the concerns respecting direct application of MSCs. The MSCs-derived exosomes comprise molecular components including lipid, proteins, DNA, microRNA, and also mRNA, which target molecular pathways and also biological activities in recipient cells (e.g., endothelial cell, keratinocyte, and fibroblast). The secreted exosome modifies macrophage activation, stimulates angiogenesis, and instigates keratinocytes and dermal fibroblast proliferations as well as migrations concurrently regulate inherent potential of myofibroblast for adjustment of turnover of the ECM. In the present review, we will focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports. © 2021, The Author(s). |
Cutaneous wounds; Differentiation; Exosome; Mesenchymal stem/stromal stem cell (MSC); Paracrine factors |
angiopoietin 1; angiopoietin 2; biomaterial; chemokine receptor CCR2; chemokine receptor CCR3; chemokine receptor CXCR1; chemokine receptor CXCR4; collagen type 1; collagen type 3; elastin; fibroblast growth factor 2; gelatinase B; immunoglobulin enhancer binding protein; interleukin 1; interleukin 6; microRNA; microRNA 21 5p; mitogen activated protein kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; platelet derived growth factor beta receptor; platelet endothelial cell adhesion molecule 1; stromal cell derived factor 1; toll like receptor 4; tumor necrosis factor; unclassified drug; vasculotropin; vasculotropin C; angiogenesis; biogenesis; cell differentiation; cell migration; cell proliferation; diabetic foot; endothelium cell; exosome; extracellular matrix; fibroblast; h |
BioMed Central Ltd |
17576512 |
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34863308 |
Review |
Q1 |
1599 |
2021 |
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47 |
Craddock N., Garbett K.M., Haywood S., Nasution K., White P., Saraswati L.A., Rizkiah C., Medise B.E., Diedrichs P.C. |
57204036842;56901034200;57339654700;57339654800;55730025700;55842541900;57339370700;57194679894;6504448191; |
‘Dove Confident Me Indonesia: Single Session’: study protocol for a randomised controlled trial to evaluate a school-based body image intervention among Indonesian adolescents |
2021 |
BMC Public Health |
21 |
1 |
2102 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119148188&doi=10.1186%2fs12889-021-11770-0&partnerID=40&md5=081ebeb058ffd74b7c5312132c820642 |
Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; University of Hawaiʻi at Mānoa, Honolulu, United States; Lazuardi Al Falah Depok Junior High School Indonesia, Kota Depok, Indonesia |
Craddock, N., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Garbett, K.M., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Haywood, S., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Nasution, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; White, P., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Saraswati, L.A., University of Hawaiʻi at Mānoa, Honolulu, United States; Rizkiah, C., Lazuardi Al Falah Depok Junior High School Indonesia, Kota Depok, Indonesia; Medise, B.E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Diedrichs, P.C., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom |
Background: Due to the prevalence and associated adverse health consequences of negative body image among adolescents globally, there is a need to develop acceptable, effective, and scalable interventions. School-based body image interventions delivered by trained teachers show promise in reducing negative body image in adolescents. However, there is currently a lack of evidenced-based body image interventions for use in low- and middle-income countries (LMICs). This paper outlines a protocol for the development and evaluation of Dove Confident Me Indonesia: Single Session, a single-session, teacher-led body image intervention for Indonesian adolescents. Method: The effectiveness of the intervention will be evaluated using a cluster randomised controlled trial design. Due to the COVID-19 pandemic, the trial will be conducted online. Trained teachers or school guidance counsellors will deliver the intervention. Self-report questionnaires will be collected at three time points: baseline, post-intervention, and two-month follow-up. The primary outcome is body esteem. Secondary outcomes are internalisation of appearance ideals, mood, engagement in life activities, tendency to engage in appearance comparisons, and skin shade satisfaction. A minimum of 1000 participants will provide 95% power to detect small-to-medium intervention effects. To account for attrition and potential internet issues, the sample will comprise of 2000 Indonesian adolescents in grades 7–9, attending state junior high schools in Surabaya, East Java. Quantitative and qualitative data on acceptability of the intervention will also be collected from teachers and students. Additionally, fidelity of lesson implementation will be assessed. This project received ethical approval from the Universitas Indonesia and the University of the West of England. The intervention will be disseminated in junior high schools throughout Indonesia via UNICEF’s Life Skills Education (LSE) programme, which will be freely available for teachers to download. Discussion: This paper presents Dove Confident Me Indonesia: Single Session, a culturally adapted school-based intervention designed to improve Indonesian adolescents’ body image. It details the plan for evaluation, highlighting the strengths and limitations of the proposed study design. It will be informative for others aiming to adapt evidence-based school curricula to promote well-being among adolescents in LMICs. Trial registration: NCT04665557. Registered 11th December 2020. © 2021, The Author(s). |
Adolescent mental health; Body image; Indonesia; Life skills education; Low- and middle-income countries; Randomised controlled trial; School-based intervention; Single-session intervention; Southeast Asia; Study protocol |
adolescent; body image; human; Indonesia; pandemic; randomized controlled trial (topic); school; school health service; Adolescent; Body Image; COVID-19; Humans; Indonesia; Pandemics; Randomized Controlled Trials as Topic; SARS-CoV-2; School Health Services; Schools |
BioMed Central Ltd |
14712458 |
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34784916 |
Article |
Q1 |
1230 |
3166 |
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