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No records
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470 |
Takhwifa F., Aninditha T., Setiawan H., Sauriasari R. |
57222711645;57189611205;55292870100;16246507200; |
The potential of metformin as an antineoplastic in brain tumors: A systematic review |
2021 |
Heliyon |
7 |
4 |
e06558 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103788211&doi=10.1016%2fj.heliyon.2021.e06558&partnerID=40&md5=ec9287d374f7d13b7c0752898249a4ba |
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Takhwifa, F., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, H., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia |
Brain tumors are challenging to handle and cause severe mortality and morbidity. The primary therapy for brain tumors, a combination of radiotherapy, chemotherapy (i.e temozolomide), and corticosteroids, is considered inadequate to improve patients' clinical conditions and associated with many adverse effects. There is an urgent need for new compounds or repurposing of existing therapies, which could improve brain tumor patients' prognosis. Metformin, commonly used for type 2 diabetes medication, has been examined for its protective action in cancer, reducing cancer risk and cancer-related mortality. However, its effect on cancer is still in rigorous debate. This study examines recent studies on the effects of metformin in primary brain tumor patients through systematic reviews. The literature search was performed on PubMed, ScienceDirect, and SpringerLink databases for articles published between 2013 and 2020. We selected clinical studies comparing the therapeutic outcomes of brain tumor therapy with and without metformin. The clinical benefits of the drug were assessed through the overall survival (OS) and progression-free survival (PFS) of brain tumor patients. Those studies demonstrated that the combination of metformin with temozolomide given post-radiotherapy resulted in better OS and PFS. Nonetheless, the efficacy and safety of metformin need further clinical testing in the wider population. © 2021 The Authors |
Antidiabetic; Antineoplastic; Metformin; Primary brain tumor; Survival |
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Elsevier Ltd |
24058440 |
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Review |
Q1 |
455 |
10919 |
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471 |
Sampurna M.T.A., Rohsiswatmo R., Primadi A., Wandita S., Sulistijono E., Bos A.F., Sauer P.J.J., Hulzebos C.V., Dijk P.H. |
57201733407;55533574600;8422152900;57194904658;57218101844;36839156800;57191375642;6603928053;6701798049; |
The knowledge of Indonesian pediatric residents on hyperbilirubinemia management |
2021 |
Heliyon |
7 |
4 |
e06661 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103706107&doi=10.1016%2fj.heliyon.2021.e06661&partnerID=40&md5=fe30c346677666133417d4195cc4b825 |
Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Sampurna, M.T.A., Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primadi, A., Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Wandita, S., Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sulistijono, E., Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Bos, A.F., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Sauer, P.J.J., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Hulzebos, C.V., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Dijk, P.H., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Hyperbilirubinemia in the newborn occurs more frequently in Indonesia. Therefore, it is important that pediatric residents in Indonesia acquire adequate knowledge of hyperbilirubinemia management. This study aims to determine the pediatric residents' knowledge on hyperbilirubinemia management, whether they follow recommended guidelines, and whether differences exist between five large Indonesian teaching hospitals. We handed out a 25-question questionnaire on hyperbilirubinemia management to pediatric residents at five teaching hospitals. A total of 250 questionnaires were filled in completely, ranging from 14 to 113 respondents per hospital. Approximately 76% of the respondents used the Kramer score to recognize neonatal jaundice. Twenty-four percent correctly plotted the total serum bilirubin levels (TSB) on the phototherapy (PT) nomograms provided by the American Academy of Pediatrics (AAP) and the National Institute for Health and Care Excellence (NICE) for full-term and nearly full-term infants. Regarding preterm infants <35 weeks' gestational age, 66% of the respondents plotted TSB levels on the AAP nomogram, although this nomogram doesn't apply to this category of infants. Seventy percent of residents knew when to perform an exchange transfusion whereas 27% used a fixed bilirubin cut-off value of 20 mg/dL. Besides PT, 25% reported using additional pharmaceutical treatments, included albumin, phenobarbitone, ursodeoxycholic acid and immunoglobulins, while 47% of the respondents used sunlight therapy, as alternative treatment. The limited knowledge of the pediatric residents could be one factor for the higher incidence of severe hyperbilirubinemia and its sequelae. The limited knowledge of the residents raises doubts about the knowledge of the supervisors and the training of the residents since pediatric residents receive training from their supervisors. © 2021 The Author(s) |
Guidelines; Hyperbilirubinemia; Knowledge; Newborn infants; Residents |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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576 |
Elvira S.D., Lamuri A., Lukman P.R., Malik K., Shatri H., Abdullah M. |
57192888533;57222088387;55981460300;57204114533;28767986500;7103393434; |
Psychological distress among Greater Jakarta area residents during the COVID-19 pandemic and community containment |
2021 |
Heliyon |
7 |
2 |
e06289 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101376515&doi=10.1016%2fj.heliyon.2021.e06289&partnerID=40&md5=f6aaf6a6409201040c1d9b4f477052ca |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Indonesia Medical Education and Research Institute, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia |
Elvira, S.D., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Lamuri, A., Indonesia Medical Education and Research Institute, Indonesia; Lukman, P.R., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Malik, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Shatri, H., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia; Abdullah, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia |
Community quarantine; COVID-19; DASS-21; Psychological distress © 2021 The AuthorsIntroduction: Coronavirus disease 2019 (COVID-19) is an emerging pandemic affecting the global population. Community-based quarantine can slow down the pandemic growth while adversely affecting population-wide psychological well-being. Affected psychological well-being could potentially influence population compliance in following stipulated community quarantine procedures. Aim: The aim was to quantify psychological distress among Greater Jakarta area residents during the community containment period. Objectives: The objective was to measure depression, anxiety, and stress levels using the Indonesian version of the DASS-21. Demographic data on sex, education strata, and working/productive-age group were also collected. Methods: This cross-sectional observational analytic study employed an online questionnaire involving participants acquired through snowball sampling. The questionnaire comprises two parts: demographic data and psychological distress indicators. Linear regression evaluated psychological distress as a response variable. Results: Among 1,205 women and 824 men, our findings suggested male sex, age in the range of 15-24 years, and having a bachelor's degree or professional qualification have a strong association with psychological distress. Conclusion: By addressing the population at risk, policymakers can identify better countermeasures for preventing psychological distress. © 2021 The Authors |
Community quarantine; COVID-19; DASS-21; Psychological distress |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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581 |
Nugroho S.W., Perkasa S.A.H., Gunawan K., Manuhutu Y.N., Rahman M.A., Rizky A. |
57460519700;57204105609;57195935319;57221807460;57221807438;57221806899; |
Predicting outcome of hemifacial spasm after microvascular decompression with intraoperative monitoring: A systematic review |
2021 |
Heliyon |
7 |
2 |
e06115 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100277933&doi=10.1016%2fj.heliyon.2021.e06115&partnerID=40&md5=b7d2f2e7bfd453c5d93d9b6eb24a6a19 |
Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia |
Nugroho, S.W., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Perkasa, S.A.H., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Gunawan, K., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Manuhutu, Y.N., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Rahman, M.A., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Rizky, A., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia |
Hemifacial spasm, Microvascular decompression, Intraoperative monitoring, Lateral spread response, Abnormal muscle response. © 2021 The AuthorsBackground: Microvascular decompression has been established as a primary treatment for hemifacial spasm. Intraoperative monitoring is used during the surgery to guide neurosurgeons to determine whether the decompression of facial nerve from the vessel is sufficient. We performed a systematic review to assess the role of lateral spread response (LSR) monitoring in predicting hemifacial spasm outcomes after microvascular decompression. Method: A systematic search of PubMed, ScienceDirect, Cochrane, and Google Scholar was conducted. We included studies that performed microvascular decompression surgery with intraoperative monitoring analyzing the correlation between lateral spread response and spasm relief. A critical appraisal was conducted for selected studies. Result: Twenty-two studies comprising 6404 cases of hemifacial spasm, which underwent microvascular decompression surgery with intraoperative monitoring, were included. Of 15 articles that assessed symptoms shortly after surgery, 12 studies showed a significant correlation between lateral spread response resolution and disappearance of spasm. Four of six studies that evaluated the outcome at 3-month follow-up showed significant relationship between LSR and outcome, so did five of six articles that assessed spasm relief at 6-month follow-up. As much as 62.5% of studies (10 of 16) showed the result at long-term follow-up (≥1-year) was not significant. Conclusion: Intraoperative monitoring during microvascular decompression surgery can be a useful tool to predict hemifacial spasm resolution. Though long-term outcomes of patients with LSR relief and persistence are similar, resolution of symptoms shortly after surgery will provide comfort to patients thereby improving their quality of life. © 2021 The Authors |
Abnormal muscle response; Hemifacial spasm; Intraoperative monitoring; Lateral spread response; Microvascular decompression |
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Elsevier Ltd |
24058440 |
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Review |
Q1 |
455 |
10919 |
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No records
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406 |
Kristianto H., Waluyo A., Gayatri D., Yunir E., Blow D. |
56121348500;57211433568;57197786176;36520254800;57192313241; |
Neuromuscular taping treatment of diabetic foot: A concept analysis |
2021 |
Clinica Terapeutica |
72 |
3 |
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231 |
235 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105531246&doi=10.7417%2fCT.2021.2320&partnerID=40&md5=c143037b6dd7fff4b19b4ba2e89b5b93 |
Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia; Faculty of Nursing, Universitas Indonesia, Indonesia; Faculty of Medicine, Universitas Indonesia, Indonesia; NeuroMuscular Taping Institute, Rome, Italy; Universitas Brawijaya, Indonesia; Universitas, Indonesia |
Kristianto, H., Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia, Faculty of Nursing, Universitas Indonesia, Indonesia, Universitas Brawijaya, Indonesia, Universitas, Indonesia; Waluyo, A., Faculty of Nursing, Universitas Indonesia, Indonesia; Gayatri, D., Faculty of Nursing, Universitas Indonesia, Indonesia; Yunir, E., Faculty of Medicine, Universitas Indonesia, Indonesia; Blow, D., NeuroMuscular Taping Institute, Rome, Italy |
Objective. The definition of neuromuscular taping (NMT) has yet to be clearly analysed as a possible treatment for diabetic foot. Case studies, theoretical analysis and results of existing research may lead to varying perceptions on the definition of NMT and its possible effects on diabetic foot. This article aims to analyse the definition of the NMT concept and furthermore as a basis for future research development on diabetic foot. Methods. The procedure for reference source search include the principal data bases using “neuromuscular taping” and “diabetic foot” keywords for the period of 2010-2019. The concept analysis uses an 8-step approach with the Walker and Avant's method. Results. Analysis of the NMT concept on diabetic foot obtained attributes of elastic tape, skin, pain, edema, injury, sensorimotor, circulation, drainage, relaxation, local, proprioceptive, motion function, strength, contraction, stabilisation, reflex, rehabilitation, care, musculoskeletal, nerve, muscles, tendons, fascia, joints, lymphatic, longitudinal, wrinkles. There were four groups of attributes, namely inflammatory response, vascularity, neuromusculoskeletal function and musculoskeletal system. NMT application benefits for diabetic foot can be attributed to improving walking function, leg position, decreasing pain response, improving body function index, improving leg muscle strength and motor function, increasing range of movement (ROM), maintaining stability of leg joint function, preventing injury, increasing strength and improving position of ankle joints, reducing stiffness, reducing edema and helping wound healing processes. Conclusions. NMT is a decompression application of an elastic tape on the skin on the diabetic foot that has the effect of reducing the inflammatory response, improving vascularity and neuromusculoskeletal function. It aims to improve neuromusculoskeletal and lymphatic system functioning due to the presence of wrinkles, indicating dilation, with local effects on the sensorimotor and proprioceptive senses in conditions of care, rehabilitation and injury. Copyright © Società Editrice Universo (SEU) |
Concept analysis; Diabetic foot; Neuromuscular taping; Operational definition |
cerebral palsy; concept analysis; diabetic foot; edema; fascia; hemiplegia; human; hypertension; inflammation; joint function; leg muscle; lymphatic drainage; motor performance; rehabilitation care; Review; systematic review; tendon; wound healing; wrinkle; athletic tape; diabetes mellitus; diabetic foot; edema; physiology; skeletal muscle; walking; Athletic Tape; Diabetes Mellitus; Diabetic Foot; Edema; Humans; Muscle, Skeletal; Walking |
Societa Editrice Universo |
00099074 |
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33956043 |
Review |
Q3 |
450 |
11019 |
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No records
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752 |
Pulungan A., Soesanti F., Tridjaja B., Batubara J. |
57192905981;37068080600;6504507193;6506167513; |
Vitamin D insufficiency and its contributing factors in primary school-aged children in Indonesia, a sun-rich country |
2021 |
Annals of Pediatric Endocrinology and Metabolism |
26 |
2 |
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92 |
98 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110706480&doi=10.6065%2fapem.2040132.066&partnerID=40&md5=a96cfde3f3454bb64c938819b9dd6387 |
Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Pulungan, A., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Soesanti, F., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tridjaja, B., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Batubara, J., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Purpose: The prevalence of rickets is increasing worldwide in association with an increase in vitamin D deficiency. This study aimed to investigate the vitamin D profile of healthy school-aged children in a sun-rich country and its contributing factors. Methods: This cross-sectional study was conducted in 120 healthy children from 7–12 years of age who live in Jakarta, Indonesia. Their demographic status, sun exposure duration time, and lifestyle were recorded using a structured questionnaire. Serum calcium, phosphate, bone-alkaline phosphatase (B-ALP), and 25-hydroxy vitamin D (25(OH)2D3) levels were measured. The participants were categorized into vitamin D sufficient and non-vitamin D sufficient groups, and we analyzed variables that contributed to the 25(OH)2D3 level. Results: Of the participants, 73 (60.8%) were vitamin D sufficient, 45 (37.5%) were vitamin D insufficient, and 2 (1.7%) were vitamin D deficient. Sex, age, body mass index, Fitzpatrick skin type, daily milk intake, and clothing type were not different between the vitamin D sufficient and non-vitamin D sufficient groups. There were no differences in serum calcium, phosphate, and B-ALP between the 2 groups. Sun exposure time was significantly longer in the vitamin D sufficient group compared with that in the non-vitamin D sufficient group (511.4 min/wk vs. 318.7 min/wk, P=0.004), and this effect remained consistent on multivariate analysis after adjustment for covariates (adjusted odds ratio, 1.002; 95% confidence interval, 1.000–1.003). More participants in the vitamin D sufficient group did not use sunscreen (59 vs. 27, P=0.02), but this finding was inconsistent with our multivariate analysis. Conclusion: Despite year-round sun exposure, approximately 1 in 3 primary school-aged children had insufficient vitamin D level. Sun exposure duration was a major contributing factor. © 2021 Annals of Pediatric Endocrinology & Metabolism. |
25-Hydroxy vitamin D; Rickets; Sun-rich country; Vitamin D deficiency |
25 hydroxyvitamin D; alkaline phosphatase bone isoenzyme; calcifediol; sunscreen; Article; blood analysis; blood sampling; body mass; calcium blood level; child; cross-sectional study; demography; female; human; human cell; human experiment; information processing; major clinical study; male; normal human; nutritional status; phosphate blood level; prevalence; primary school; radioimmunoassay; rickets; school child; skin color; structured questionnaire; sun exposure; vitamin blood level; vitamin D deficiency |
Korean society of pediatric endocrinology |
22871012 |
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Article |
Q2 |
448 |
11054 |
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No records
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13 |
Sumapraja K., Hestiantoro A., Liem I.K., Boediono A., Jacoeb T.Z. |
55819683500;8743255100;55802927800;9040094200;57192887569; |
Effect of conditioned medium of umbilical cord-derived mesenchymal stem cells as a culture medium for human granulosa cells: An experimental study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
12 |
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1037 |
1044 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124898321&doi=10.18502%2fijrm.v19i12.10054&partnerID=40&md5=aa14230b44e7cc7c0f12adca3c46c2b5 |
Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Sumapraja, K., Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hestiantoro, A., Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Boediono, A., Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jacoeb, T.Z., Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Background: The umbilical cord-derived mesenchymal stem cells conditioned medium (UC-MSCs-CM) produces secretomes with anti-apoptotic properties, and has the potential to prevent apoptosis of granulosa cells (GC) during controlled ovarian hyperstimulation. Objective: To observe the effect of UC-MSCs-CM on the interaction between pro-and anti-apoptotic proteins and the influence of growth differentiation factor 9 (GDF9) production in GC. Materials and Methods: UC-MSCs-CM was collected from umbilical cord stem cell culture on passage 4. GC from 23 women who underwent in vitro fertilization were cultured and exposed to UC-MSCs-CM for 24 hr. Then RNA of the GC was extracted and the mRNA expression of BCL-2 associated X (BAX), survivin and GDF9 were analysed using quantitative real-time PCR. The spent culture media of the GC were collected for measurement of insulin growth factor 1 using ELISA. Results: The expression of BAX was significantly different after UC-MSCs-CM exposure (4.09E-7 vs. 3.74E-7, p = 0.02). No significant changes occurred in survivin, BAX/survivin ratio, and GDF9 expression after UC-MSCs-CM exposure (p > 0.05). The IGF-1 level of the CM was significantly higher after the CM was used as a culture medium for GC (2.28 vs. 3.07 ± 1.72, p ≤ 0.001). A significant positive correlation was found between survivin and GDF9 (r = 0.966, p ≤ 0.001). Conclusion: IGF-1 produced by UC-MSCs-CM can work in paracrine fashion through the IGF receptor, which can inhibit BAX and maintain GDF9 production. Moreover, under the influence of UC-MSCs-CM, GC are also capable of producing IGF-1, which can impact GC through autocrine processes. © Sumapraja et al. |
BAX; Conditioned medium; GDF9; IGF-1; Survivin |
anti apoptotic protein; baculoviral IAP repeat containing protein 5; complementary DNA; growth differentiation factor 9; Muellerian inhibiting factor; pro apoptotic protein; protein; protein Bax; protein bcl 2; recombinant follitropin; somatomedin; unclassified drug; adult; anesthesia; antiapoptotic activity; antral follicle count; Article; autocrine signaling; cell culture; clinical article; DNA synthesis; enzyme linked immunosorbent assay; female; granulosa cell; human; human cell; in vitro fertilization; information processing; mRNA expression level; oocyte; ovary follicle fluid; real time polymerase chain reaction; RNA extraction; umbilical cord mesenchymal stem cell |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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300 |
Muharam R., Rizal M.S. |
57191492732;57226812403; |
Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
7 |
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637 |
644 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112743809&doi=10.18502%2fijrm.v19i7.9474&partnerID=40&md5=34cae0bd86e4721b17270090a5a30ef4 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Muharam, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Rizal, M.S., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: Endometriosis is closely associated with delayed diagnosis due to the lack of a definitive and sensitive noninvasive approach. The use of calprotectin in inflammatory process has been demonstrated in various inflammatory diseases. Calprotectin has a significant correlation with high-sensitivity C-reactive protein (hs-CRP) and could be used as an inflammatory marker. No study thus far has evaluated the correlation between calprotectin and endometriosis. Objective: To determine the correlation of calprotectin with the degree of endometriosis in order to help clinicians in establishing better early detection and management. Materials and Methods: In this cross-sectional study, 46 women referred to the Cipto Mangunkusumo, Fatmawati, and Persahabatan Hospitals in Jakarta, Indonesia between July 2017 and April 2018 were enrolled, and their blood serum were taken a day before surgery. Calprotectin serum level was treated using the Phical® ELISA method. After the diagnosis of endometriosis was confirmed through pathological examination, the final diagnosis of endometriosis could be established. The degree of endometriosis was classified according to the revised American Society for Reproductive Medicine (ASRM) classification. Results: The prevalence of minimal, mild, moderate, and severe degrees of endometriosis were 15.2, 39.1, 34.8, and 10.9%, respectively. The median serum calprotectin levels for minimal, mild, moderate, and severe endometriosis were 138.98, 121.49, 124.16, and 122.82 mg/mL, respectively. No correlation was observed between calprotectin and the degrees of endometriosis (r = –0.16, p = 0.278). Conclusion: There is no correlation between calprotectin serum levels and the degrees of endometriosis. © Muharam et al. |
C-reactive protein; Calprotectin; Endometriosis; Inflammation |
biological marker; C reactive protein; calgranulin; adolescent; adult; Article; body mass; correlation coefficient; cross-sectional study; diabetes mellitus; diastolic blood pressure; early diagnosis; endometriosis; enzyme linked immunosorbent assay; female; female infertility; glucose blood level; human; hypertension; major clinical study; protein expression |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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No records
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712 |
Rohsiswatmo R., Azharry M., Sari T.T., Bahasoan Y., Wulandari D. |
55533574600;57263156500;36519483600;57263337000;57204024903; |
TLR2 and TLR4 expressions in late-onset neonatal sepsis: Is it a potential novel biomarker? |
2021 |
Journal of Neonatal-Perinatal Medicine |
14 |
3 |
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361 |
367 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115150896&doi=10.3233%2fNPM-200411&partnerID=40&md5=6cf4f414e02f524e32c55a2f9864c09a |
Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rohsiswatmo, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Azharry, M., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sari, T.T., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bahasoan, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wulandari, D., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Late-onset neonatal sepsis (LONS) detection is problematic as no single examinations (blood culture, c-reactive protein (CRP), procalcitonin (PCT)) are reliable. Toll-like receptors (TLRs), which detect the presence of pathogen-associated molecular patterns is a promising novel biomarker, but less studied in LONS. This study aimed to determine neutrophils and monocytes TLR2 and TLR4 expression in LONS and their diagnostic value. METHODS: A cross-sectional study conducted in May and June 2017 involving 52 neonates with clinical late-onset (>72 hours of age) sepsis. We examine complete blood count, I/T ratio, CRP, PCT, as well as TLR2 and TLR4 expression to compared with blood culture as the gold standard. We classified cases into proven or unproven sepsis. RESULT: The incidence of LONS was 32.6% in the subjects. The expression of TLR2 was low in LONS, while TLR4 was high. TLR4 neutrophil expression has 88.2% sensitivity, 20% specificity, 34.9% positive predictive value (PPV), 77.8% negative predictive value (NPV), and an AUC of 0.541. TLR4 monocyte expression has 92.1% sensitivity, 11.4% specificity, 34% PPV, 80% NPV, and an AUC of 0.528. The AUC of CRP is increased from 0.608 to 0.843 after combination with TLR4, comparable with CRP + PCT (AUC 0.829). CONCLUSION: The increase in TLR4 expression has good sensitivity but low specificity. TLR4 expression, in combination with CRP, could become a reliable biomarker for the diagnosis of LONS. © 2021-IOS Press. All rights reserved. |
biomarker; c-reactive protein; Late-onset neonatal sepsis; procalcitonin; TLR2; TLR4 |
biological marker; C reactive protein; procalcitonin; toll like receptor 2; toll like receptor 4; biological marker; C reactive protein; TLR2 protein, human; TLR4 protein, human; toll like receptor 2; toll like receptor 4; Acinetobacter baumannii; Article; blood cell count; blood culture; controlled study; cross-sectional study; diagnostic test accuracy study; diagnostic value; female; gold standard; human; Klebsiella pneumoniae; late onset disorder; low birth weight; major clinical study; male; monocyte count; neutrophil count; newborn; newborn sepsis; nonhuman; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; sepsis; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Humans; Infant, Newborn; Neonatal Sepsis; Sepsis; Toll-Like Rec |
IOS Press BV |
19345798 |
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33164948 |
Article |
Q2 |
444 |
11146 |
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