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Miranda A.V., Wiyono L., Rocha I.C.N., Cedeño T.D.D., Lucero-Prisno D.E., III |
57222664687;57207889054;57223283646;57224097138;56051373800; |
Strengthening virology research in the association of Southeast Asian nations: Preparing for future pandemics |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
5 |
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1141 |
1143 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119604704&doi=10.4269%2fajtmh.21-0589&partnerID=40&md5=98ad7364acccdc95ee57ef0ea9e65ed9 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
Miranda, A.V., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyono, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Cedeño, T.D.D., School of Medicine, Centro Escolar University, Manila, Philippines; Lucero-Prisno, D.E., III, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
The Association of Southeast Asian Nations (ASEAN) region is known to be a global hotspot to viral outbreaks because of many factors. To limit the impact of future outbreaks, it is crucial for the ASEAN governments to strengthen regional virology research capacity. The ASEAN governments have collaborated in several virology initiatives, with the most recent being the establishment of the ASEAN Regional Center for Public Health Emergencies and Emerging Diseases. However, several challenges, including technology disparities, nationalistic tendencies, and the lack of public acceptance toward virus sharing, need to be addressed to maximize the region’s collaboration potential in virology research. We recommend the governments to 1) prioritize the strengthening of research capacities; 2) develop stronger cooperation and possible centralization of efforts on top of national capacities; 3) develop an equitable and secure research framework; and 4) improve the public awareness regarding the importance of regional public health responses. Copyright © 2021 by The American Society of Tropical Medicine and Hygiene |
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epidemic; human; medical research; organization and management; pandemic; Southeast Asia; virology; Asia, Southeastern; Biomedical Research; Disease Outbreaks; Humans; Pandemics; Virology |
American Society of Tropical Medicine and Hygiene |
00029637 |
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34506300 |
Article |
Q1 |
1015 |
4298 |
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147 |
Merati T.P., Karyana M., Tjitra E., Kosasih H., Aman A.T., Alisjahbana B., Lokida D., Arlinda D., Maldarelli F., Neal A., Arif M., Gasem M.H., Lukman N., Sudarmono P., Lau C.-Y., Hadi U., Lisdawati V., Wulan W.N., Lane H.C., Siddiqui S. |
57203678680;24449083500;57204151009;6507043017;6701594071;6506944516;57190663838;57218444330;57210198407;57220466230;56740206600;6508371601;57190737414;6507855437;16245242000;55804160500;56786334300;57204491118;57197596240;8707129300; |
Prevalence of HIV infection and resistance mutations in patients hospitalized for febrile illness in Indonesia |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
4 |
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960 |
965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117017901&doi=10.4269%2fajtmh.20-1595&partnerID=40&md5=f52639e32eebbadb71cd505b119b26d4 |
Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia; Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia; National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia; Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia; Indonesia Research Partnership on Infections Disease, Jalan Percetakan Negara No. 29, Jakarta, 10560, Indonesia |
Merati, T.P., Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Karyana, M., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia, Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Tjitra, E., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia; Kosasih, H., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia, Indonesia Research Partnership on Infections Disease, Jalan Percetakan Negara No. 29, Jakarta, 10560, Indonesia; Aman, A.T., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Alisjahbana, B., Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Lokida, D., Department of Clinical Pathology, Tangerang District Hospital, Tangerang, Indonesia; Arlinda, D., National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia, Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Maldarelli, F., National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Neal, A., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Arif, M., Faculty of Medicine, Universitas Hasanudin, Makassar, Indonesia; Gasem, M.H., Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Lukman, N., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Sudarmono, P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lau, C.-Y., National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Hadi, U., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Lisdawati, V., Sulianti Saroso, Infectious Disease Hospital, Jakarta, Indonesia; Wulan, W.N., Indonesia Research Partnership on Infectious Disease (INA-RESPOND), Jakarta, Indonesia; Lane, H.C., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; Siddiqui, S., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States |
HIV prevalence in Indonesia is increasing, and only 64% of infected individuals know their status. In a prospective cohort of 1,453 hospitalized patients with unexplained fever, 46 (3.2%) had HIV, including 15 (1.1%) patients without a prior HIV diagnosis. Among 31 subjects previously known to have HIV, 21 (68%) had been receiving combination antiretroviral therapy (cART) at the time of enrollment. Of 39 HIV cases with HIV RNA levels $ 100 copies/mL, sequencing for genotype analysis and resistance testing was successful in 30 (77%) subjects. The most common HIV subtypes were AE (90%) and B (10%). Five (16.7%) subjects had resistance mutations to nucleoside and non-nucleoside reverse transcriptase inhibitors, and all of them were on cART. No evidence of transmitted drug resistance was found in newly diagnosed individuals. Hospital-based screening may be an efficient method to expand HIV testing and identify a significant number of new cases. Access to care, close monitoring, expansion of anti-retroviral options, and ensuring availability of CD4 determinations, viral load testing, and genotyping are crucial to control of the epidemic in Indonesia. © 2021 by The American Society of Tropical Medicine and Hygiene |
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nonnucleoside reverse transcriptase inhibitor; RNA directed DNA polymerase inhibitor; virus RNA; anti human immunodeficiency virus agent; adolescent; adult; aged; antiretroviral therapy; Article; child; cohort analysis; combination drug therapy; female; fever; genotype; hospital patient; hospitalization; human; Human immunodeficiency virus infection; Indonesia; major clinical study; male; nonhuman; prevalence; prospective study; virus mutation; virus resistance; antiviral resistance; drug effect; genetics; Human immunodeficiency virus 1; Human immunodeficiency virus infection; infant; middle aged; mutation; preschool child; very elderly; virology; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Child; Child, Preschool; Drug Resistance, Viral; Female; HIV Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
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34460416 |
Article |
Q1 |
1015 |
4298 |
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203 |
Sasmono R.T., Johar E., Yohan B., Ma’Roef C.N., Soebandrio A., Myint K.S.A., Pronyk P., Hadinegoro S.R., Soepardi E.J., Bouckenooghe A., Hawley W., Rosenberg R., Powers A.M. |
57245712300;57204001174;55843037500;6507740388;8602893200;7003758970;6602466584;57226218772;57191174412;18233281300;7004280510;35578810900;7005770718; |
In Response: Stability of zika virus antibodies in specimens from a retrospective serological study |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
3 |
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853 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115293744&doi=10.4269%2fajtmh.21-0564b&partnerID=40&md5=4b5e07961e6006f21355f4fdf73c7fa8 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; UNICEF Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Sanofi Pasteur Lyon, Rhone-Alpes, France; Centers for Disease Control and Prevention, Atlanta, GA, United States; Centers for Disease Control and Prevention Fort, Collins, CO, United States |
Sasmono, R.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Johar, E., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Yohan, B., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Ma’Roef, C.N., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S.A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Pronyk, P., UNICEF Indonesia, Jakarta, Indonesia; Hadinegoro, S.R., Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soepardi, E.J., Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Bouckenooghe, A., Sanofi Pasteur Lyon, Rhone-Alpes, France; Hawley, W., Centers for Disease Control and Prevention, Atlanta, GA, United States; Rosenberg, R., Centers for Disease Control and Prevention Fort, Collins, CO, United States; Powers, A.M., Centers for Disease Control and Prevention Fort, Collins, CO, United States |
[No abstract available] |
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immunoglobulin G antibody; virus antibody; enzyme linked immunosorbent assay; freezing; Letter; plaque reduction neutralization test; serology; storage; Zika virus; human; retrospective study; serodiagnosis; Zika fever; Humans; Neutralization Tests; Retrospective Studies; Zika Virus; Zika Virus Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
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34314374 |
Letter |
Q1 |
1015 |
4298 |
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No records
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373 |
Dewi R., Kaswandani N., Karyanti M.R., Setyanto D.B., Pudjiadi A.H., Hendarto A., Djer M.M., Prayitno A., Yuniar I., Indawati W., Prawira Y., Handryastuti S., Sjakti H.A., Hidayati E.L., Muktiarti D., Soebadi A., Puspaningtyas N.W., Muhaimin R., Rahmadhany A., Octavius G.S., Puspitasari H.A., Jasin M.R., Tartila T., Putri N.D. |
57190859324;57195941745;56290680800;57203009929;18435202300;57204142249;12771087900;57193342301;57222295046;57190171077;55455747000;18434003700;57195720458;57200542624;57189047743;56986580800;57223288515;57223307995;57223290366;57221016506;57214119502;57223292665;57223304533;57200573842; |
Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia |
2021 |
International Journal of Infectious Diseases |
107 |
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78 |
85 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105478543&doi=10.1016%2fj.ijid.2021.04.019&partnerID=40&md5=6ef75a9ece8a84ed984ec94cf9c3f923 |
Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dewi, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karyanti, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyanto, D.B., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pudjiadi, A.H., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hendarto, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djer, M.M., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prayitno, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yuniar, I., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indawati, W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prawira, Y., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handryastuti, S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sjakti, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayati, E.L., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muktiarti, D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soebadi, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspaningtyas, N.W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muhaimin, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmadhany, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Octavius, G.S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspitasari, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jasin, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tartila, T., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The incidence of coronavirus disease 2019 (COVID-19) is still increasing rapidly, but little is known about the prevalence and characteristics of fatal cases in children in Indonesia. This study aimed to describe the characteristics of children with COVID-19 with fatal outcomes in a tertiary referral hospital in Indonesia. Methods: This cross-sectional study used data collected from the medical records of patients with COVID-19 admitted to Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia from March to October 2020. Results: During the study period, 490 patients were admitted and diagnosed with suspected and probable COVID-19. Of these patients, 50 (10.2%) were confirmed to have COVID-19, and 20 (40%) had a fatal outcome. The fatality rate was higher in patients aged ≥10 years, categorized with severe disease upon admission, PaO2/FiO2 ratio ≤300 mmHg and chronic underlying diseases. The most common clinical manifestations were generalized symptoms, while acute respiratory distress syndrome (8/20) and septic shock (7/20) were the two most common causes of death. Increased procalcitonin, D-dimer, lactate dehydrogenase and presepsin levels were found in all fatal cases. One patient met the criteria of multisystem inflammatory syndrome in children. Conclusion: Our work highlights the high mortality rate in paediatric patients with positive SARS-CoV-2 polymerase chain reaction test. These findings might be related to or co-incided with COVID-19 infection. Further studies are needed to improve understanding of the role of severe acute respiratory syndrome coronavirus-2 in elaborating the mechanisms leading to death in children with comorbidities. © 2021 The Author(s) |
Children; COVID-19; Indonesia; Outcome; SARS-CoV-2 |
antibiotic agent; biological marker; D dimer; dobutamine; dopamine; enoxaparin; epinephrine; hydrocortisone; immunoglobulin; lactate dehydrogenase; lopinavir; noradrenalin; presepsin; procalcitonin; ritonavir; steroid; unclassified drug; adolescent; adult; adult respiratory distress syndrome; age; Article; artificial ventilation; cause of death; child; childhood mortality; clinical feature; coronavirus disease 2019; cross-sectional study; disease severity; fatality; female; Horowitz index; hospital admission; human; Indonesia; infant; major clinical study; male; mortality rate; newborn; pediatric multisystem inflammatory syndrome; polymerase chain reaction; preschool child; real time polymerase chain reaction; school child; septic shock; tertiary care center; complication; mortality; Adole |
Elsevier B.V. |
12019712 |
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33857609 |
Article |
Q1 |
1278 |
2980 |
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9 |
Wahidiyat P.A., Yo E.C., Wildani M.M., Triatmono V.R., Yosia M. |
24400464000;57213188908;57223404540;57225083843;57204933098; |
Cross-sectional study on knowledge, attitude and practice towards thalassaemia among Indonesian youth |
2021 |
BMJ Open |
11 |
12 |
e054736 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121204786&doi=10.1136%2fbmjopen-2021-054736&partnerID=40&md5=254c5b647a17fbed23378ced6a556eb2 |
Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Hematology and Oncology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wahidiyat, P.A., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Hematology and Oncology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia; Yo, E.C., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wildani, M.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Triatmono, V.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction Thalassaemia is an inherited blood disorder, for which definitive treatments remain largely inaccessible. The recommended approach to reduce the disease burden is by prevention through screening. Currently, the implementation of thalassaemia preventive measures is poorly regulated in Indonesia. Thalassaemia prevention and education are best targeted to the youth, but information on their awareness towards thalassaemia is limited. This study aims to investigate the knowledge, attitude and practice (KAP) towards thalassaemia among Indonesian youth. Methods This observational study took place between January and May 2021. An online questionnaire was disseminated to Indonesian youth aged 15-24. Eligible respondents included carriers, unaffected individuals and individuals with unknown carrier status. The questionnaire comprised 28 questions to assess KAP. A cut-off of 75% was used to categorise participant's KAP into poor or negative and good or positive. Descriptive statistics, χ 2 test, logistic regression and Pearson correlation were performed for data analysis. Results A total of 906 responses were gathered, and 878 were analysed. Most respondents had poor knowledge (62.1%), positive attitude (83.3%) and poor practice (54.4%) towards thalassaemia. The results implied that respondents had limited understanding regarding the types of thalassaemia and the difference between asymptomatic carriers and individuals without the thalassaemia trait. Many (82.6%) believed they were not carrying thalassaemia trait despite the fact that most (95.7%) never got tested. Age, education, gender, residence and family income were key factors that correlated with or predicted the youth's KAP towards thalassaemia. Older respondents and women were more likely to have good KAP. Conclusion Thalassaemia screening targeted to the youth is urgently needed, and future interventions must consider sociodemographic factors that may affect how they perceive the disease. Social media appeals to the youth as an important source of information, but school, parents and health professionals should also be involved in delivering education about thalassaemia. © BMJ Publishing Group Limited 2021. |
community child health; haematology; paediatrics; public health |
adolescent; adult; age distribution; Article; asymptomatic carrier; attitude to health; bone marrow transplantation; child health; controlled study; cross-sectional study; demography; educational status; family income; female; gene therapy; human; Indonesia; juvenile; leukemia; major clinical study; male; observational study; questionnaire; screening test; self concept; sex difference; thalassemia; thalassemia major |
BMJ Publishing Group |
20446055 |
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34862299 |
Article |
Q1 |
1132 |
3624 |
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33 |
Umbarawan Y., Kawakami R., Syamsunarno M.R.A.A., Obinata H., Yamaguchi A., Hanaoka H., Hishiki T., Hayakawa N., Koitabashi N., Sunaga H., Matsui H., Kurabayashi M., Iso T. |
57196077830;57210447153;36142388300;6506181723;23394341400;56020036100;7004072867;57221461061;6603109711;55061468300;57212330485;7103371684;7003498756; |
Reduced fatty acid use from cd36 deficiency deteriorates streptozotocin-induced diabetic cardiomyopathy in mice |
2021 |
Metabolites |
11 |
12 |
881 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121605641&doi=10.3390%2fmetabo11120881&partnerID=40&md5=50b9a38996d07912da5741dbe717f2f0 |
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta, 10430, Indonesia; Department of Biomedical Sciences, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Jatinangor, 45363, Indonesia; Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Center for Liberal Arts and Sciences, Ashikaga University, 268-1 Omae-Machi, Ashikaga, 326-8558, Japan; Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, 191-1 Kawamagari-Machi, Maebashi, 371-0823, Japan |
Umbarawan, Y., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta, 10430, Indonesia; Kawakami, R., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Syamsunarno, M.R.A.A., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Biomedical Sciences, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Jatinangor, 45363, Indonesia; Obinata, H., Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Yamaguchi, A., Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Hanaoka, H., Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Hishiki, T., Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan, Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Hayakawa, N., Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan, Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Koitabashi, N., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Sunaga, H., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Center for Liberal Arts and Sciences, Ashikaga University, 268-1 Omae-Machi, Ashikaga, 326-8558, Japan; Matsui, H., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Kurabayashi, M., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Iso, T., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, 191-1 Kawamagari-Machi, Maebashi, 371-0823, Japan |
Cardiac dysfunction is induced by multifactorial mechanisms in diabetes. Deranged fatty acid (FA) utilization, known as lipotoxicity, has long been postulated as one of the upstream events in the development of diabetic cardiomyopathy. CD36, a transmembrane glycoprotein, plays a major role in FA uptake in the heart. CD36 knockout (CD36KO) hearts exhibit reduced rates of FA transport with marked enhancement of glucose use. In this study, we explore whether reduced FA use by CD36 ablation suppresses the development of streptozotocin (STZ)-induced diabetic cardiomyopathy. We found that cardiac contractile dysfunction had deteriorated 16 weeks after STZ treatment in CD36KO mice. Although accelerated glucose uptake was not reduced in CD36KO-STZ hearts, the total energy supply, estimated by the pool size in the TCA cycle, was significantly reduced. The isotopomer analysis with13 C6-glucose revealed that accelerated glycolysis, estimated by enrichment of13 C2-citrate and13 C2-malate, was markedly suppressed in CD36KO-STZ hearts. Levels of ceramides, which are cardiotoxic lipids, were not elevated in CD36KO-STZ hearts compared to wild-type-STZ ones. Furthermore, increased energy demand by transverse aortic constriction resulted in synergistic exacerbation of contractile dysfunction in CD36KO-STZ mice. These findings suggest that CD36KO-STZ hearts are energetically compromised by reduced FA use and suppressed glycolysis; therefore, the limitation of FA utilization is detrimental to cardiac energetics in this model of diabetic cardiomyopathy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
CD36; Ceramide; Diabetic cardiomyopathy; Fatty acid; Glucose; Metabolomics; Streptozotocin |
CD36 antigen; fatty acid; fluorodeoxyglucose f 18; formaldehyde; glucose; glycogen; insulin; isoflurane; liquid nitrogen; streptozocin; triacylglycerol; animal cell; animal experiment; animal model; animal tissue; aortic constriction; Article; biochemical analysis; capillary electrophoresis; centrifugation; citric acid cycle; controlled study; diabetes mellitus; diabetic cardiomyopathy; energy resource; enzyme linked immunosorbent assay; fatty acid blood level; fatty acid transport; fibrosis; genotype; glucose blood level; glucose transport; glycogen level; heart disease; heart function; heart rate; hemodynamics; knockout gene; knockout mouse; lactate blood level; liquid chromatography-mass spectrometry; male; mass spectrometry; Masson trichrome stain; metabolic fingerprinting; metabolome; |
MDPI |
22181989 |
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Article |
Q2 |
1109 |
3744 |
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38 |
Dhelika R., Hadi A.F., Yusuf P.A. |
55536628000;57368046500;57192156597; |
Development of a motorized hospital bed with swerve drive modules for holonomic mobility |
2021 |
Applied Sciences (Switzerland) |
11 |
23 |
1356 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120877522&doi=10.3390%2fapp112311356&partnerID=40&md5=7c16eb6fe630116772c69c4d02b4bd9f |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Dhelika, R., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Hadi, A.F., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Yusuf, P.A., Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
In hospitals; transferring patients using hospital beds is time consuming and inefficient. Additionally; the task of frequently pushing and pulling beds poses physical injury risks to nurses and caregivers. Motorized hospital beds with holonomic mobility have been previously proposed. However; most such beds come with complex drivetrain which makes them costly and hinders larger‐scale adoption in hospitals. In this study; a motorized hospital bed that utilizes a swerve drive mechanism is proposed. The design takes into account simplicity which would allow for minimum modification of the existing beds. Two DC motors for steering and propulsion are used for a single swerve drive module. The control of the propulsion motor is achieved by a combination of trajectory planning based on quintic polynomials and PID control. Further; the control performance of the proposed bed was evaluated; and the holonomic mobility of its prototype was successfully demonstrated. An average error of less than 3% was obtained for motion with a constant velocity; however; larger values in the range of 15% were observed for other conditions, such as accelerating and decelerating. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Hospital bed; Mechatronics; PID control; Swerve drive; Trajectory planning |
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MDPI |
20763417 |
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Article |
Q2 |
435 |
11324 |
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56 |
Gunardi E.R., Surya R., Syafitri I., Pasidri Y. |
57192910998;56986345100;57195381844;57226151144; |
Impact of one-rod levonorgestrel implant on the blood chemistry profile |
2021 |
Scientific Reports |
11 |
1 |
20141 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116742568&doi=10.1038%2fs41598-021-99801-z&partnerID=40&md5=604f40cda19708636ac9b97fd82f17a7 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syafitri, I., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The aim of this study was to investigate the effect of a one-rod levonorgestrel implant on the blood chemistry profile, including random blood glucose (RBG), haemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and the lipid profile, including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta, from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated every 6 month up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. p < 0.05 was considered a significant value. The Hb, RBG, AST, and lipid profile levels were significantly different before and 6 months after one-rod implant insertion (p < 0.05). However, for 24 months, all of the parameters were still within normal limits and did not differ clinically. One-rod levonorgestrel implant insertion has a minimal effect on all blood chemistry profiles. © 2021, The Author(s). |
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cholesterol; contraceptive agent; high density lipoprotein cholesterol; levonorgestrel; lipid; low density lipoprotein cholesterol; triacylglycerol; adult; blood; blood analysis; drug implant; female; human; phase 2 clinical trial (topic); procedures; prospective study; young adult; Adult; Blood Chemical Analysis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials, Phase II as Topic; Contraceptive Agents, Female; Drug Implants; Female; Humans; Levonorgestrel; Lipids; Prospective Studies; Triglycerides; Young Adult |
Nature Research |
20452322 |
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34635768 |
Article |
Q1 |
1240 |
3130 |
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63 |
Irwinda R., Hiksas R., Siregar A.A., Saroyo Y.B., Wibowo N. |
57190855256;57226152029;57226157581;57164888400;15049026900; |
Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study |
2021 |
Scientific Reports |
11 |
1 |
14701 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110662198&doi=10.1038%2fs41598-021-93846-w&partnerID=40&md5=f379da0f3a9e78e16af9cc0ca6bb9968 |
Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Siregar, A.A., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Long-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status. © 2021, The Author(s). |
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unsaturated fatty acid; adult; blood; case control study; cross-sectional study; female; human; Indonesia; male; newborn; nutritional status; pathology; preeclampsia; pregnancy; prematurity; severity of illness index; young adult; Adult; Case-Control Studies; Cross-Sectional Studies; Fatty Acids, Unsaturated; Female; Humans; Indonesia; Infant, Newborn; Male; Nutritional Status; Pre-Eclampsia; Pregnancy; Premature Birth; Severity of Illness Index; Young Adult |
Nature Research |
20452322 |
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34282168 |
Article |
Q1 |
1240 |
3130 |
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65 |
Setiawan E.A., Rianda D., Kadim M., Meilianawati, Susanto F., Kok F.J., Shankar A.H., Agustina R. |
57214103232;57214119630;26644177600;57224214324;57224212671;56506613800;7005442634;57214141404; |
Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence |
2021 |
Scientific Reports |
11 |
1 |
11860 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107265110&doi=10.1038%2fs41598-021-88819-y&partnerID=40&md5=ffa4a369e5635d1edafff9d5559b7d3c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Setiawan, E.A., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Rianda, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kadim, M., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Meilianawati, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Susanto, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Kok, F.J., Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Shankar, A.H., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Microbiota and its modification with specific probiotics in early life could provide long term health benefits. Probiotics and calcium strengthen intestinal integrity and may support linear growth. This study investigated the long-term effects of childhood probiotics and calcium supplementation on growth in adolescence. We re-enrolled 238 adolescents aged 11–18 years from 494 children 10-years after 6-months of supplementation with either low-lactose milk fortified with low levels of calcium (LC, ∼50 mg/day, n = 53/124), with regular levels of calcium (RC, ∼440 mg/day, n = 70/126), or with regular calcium + 5 x 108 CFU/day Lactobacillus reuteri DSM 17938 (Reuteri, n = 55/124), or regular calcium + 5 x 108 CFU/day L. casei CRL 431 (Casei, n = 60/120). Changes in height-for-age z-score (HAZ) and body mass index-for-age z-score (BMIZ) were determined from the end of intervention to re-enrollment. General linear models were used to assess the effects on HAZ and BMIZ of group, gender, living area, maternal education, family income, physical activity, diet quality, nutritional status, and gut integrity as determined by urinary lactulose/mannitol ratio (L:M). Adolescent mean age was 15.3 years, mean HAZ was − 1.11, mean BMIZ was − 0.2 and median L:M (n = 155) was 0.23. Changes in HAZ and BMIZ were not significantly different between Casei, Reuteri, LC compared to RC. However, a significant decrease in BMIZ was observed among female adolescents in the Casei compared to RC group (− 0.5 SD, 95% CI − 0.8 to − 0.003, p = 0.048). Childhood probiotic and calcium supplementation may therefore selectively affect female adolescents. Clinical trial registration: This follow-up study has been registered at www.clinicaltrials.gov, Registry name: Rina Agustina, Registration number: NCT04046289, First Registration Date 06/08/19. web link: https://www.clinicaltrials.gov/ct2/show/NCT04046289. © 2021, The Author(s). |
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lactulose; mannitol; probiotic agent; administration and dosage; adolescent; body height; body mass; body weight; calcium intake; controlled study; diet therapy; dietary supplement; double blind procedure; epidemiology; female; follow up; fortified food; health auxiliary; human; Indonesia; Lactobacillus casei; Lactobacillus reuteri; male; nutritional status; randomized controlled trial; risk factor; statistical model; Adolescent; Body Height; Body Mass Index; Body Weight; Calcium, Dietary; Community Health Workers; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies; Food, Fortified; Humans; Indonesia; Lactobacillus casei; Lactobacillus reuteri; Lactulose; Linear Models; Male; Mannitol; Nutrition Therapy; Nutritional Status; Probiotics; Risk Factors |
Nature Research |
20452322 |
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34088920 |
Article |
Q1 |
1240 |
3130 |
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