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No records
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87 |
Miranda E., Bramono K., Rizky L.A., Hayun |
57208259598;9843236700;57193502812;37053937800; |
Preparation and stability evaluation of ll-37 cream |
2021 |
International Journal of Applied Pharmaceutics |
13 |
6 |
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139 |
143 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121048883&doi=10.22159%2fIJAP.2021V13I6.39639&partnerID=40&md5=1b6a1a02cc0417196461dd2568afa7d5 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rizky, L.A., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hayun, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Objective: The present study aimed to prepare LL-37 in a cream formulation (O/W emulsion) and evaluate its stability by determining the physical changes in the cream and concentration of LL-37 using validated high-performance liquid chromatography. Methods: The method was conducted at room temperature using a C18 column (5 µm × 250 mm × 4.6 mm) as a stationary phase, a mixture of 0.1% trifluoroacetic acid (TFA)/water (A) and 0.1% TFA/acetonitrile (B) (85:15) as the mobile phase, a flow rate of 1.0mL/min, an d photodiode array set at 228 nm as the detector. The method was validated in compliance with the Association of Official Analytical Chemists and International Conference on Harmonization guidelines. It demonstrated excellent linearity, accuracy, precision, specificity, the limit of detection, and limit of quantitation. Results: The chromatographic analysis indicated minimal degradation of LL-37 during the 12-week, with a predicted expiry time of 99 and 75 mo stored at 4 °C and 28 °C, respectively. Conclusion: LL-37 cream establishes good physical characteristics and stabilizes the active ingredient, especially at 4 °C and 28 °C storage. Therefore, the emulsion delivery system of LL-37 cream is harmless and stable as a novel alternative vehicle of LL-37. © 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd. |
Cream; High-performance liquid chromatography; LL-37; Stability |
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Innovare Academics Sciences Pvt. Ltd |
09757058 |
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Article |
Q3 |
238 |
17272 |
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93 |
Zizlavsky S., Anam K., Suwento R., Rahmawati I. |
57195721920;57474576600;55743638800;57372516200; |
The effects of Goldenhar Syndrome on hearing and speech development |
2021 |
Medical Journal of Malaysia |
76 |
6 |
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946 |
949 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121118699&partnerID=40&md5=ccde190cb788d0255d331b7adfe1295c |
Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Zizlavsky, S., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Anam, K., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suwento, R., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmawati, I., Department of Otorhinolaryngology-Head & Neck Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Goldenhar syndrome is a congenital abnormality with an incidence of 1 in 5,200 to 26,500 births. This syndrome is characterized by facial asymmetry, ear malformation, and/or defects in the eyes and vertebrae. The hearing disorder manifests as both conductive or sensorineural due to the abnormalities occurring in the inner and outer ear. We report a case of a 1-year-3-month-old child presenting with left anotia and right microtia, severe bilateral conductive hearing loss, and global delayed development. The patient was also found to have a hemifacial microsomia, a secundum atrial septal defect (ASD), and a ventricular septal defect (VSD). The patient was advised to use hearing aids and participate in speech therapy. The management of this Goldenhar syndrome patient should be done comprehensively, appropriate to the abnormalities found to achieve the best result. © 2021, Malaysian Medical Association. All rights reserved. |
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anterior inferior cerebellar artery; Article; audiology; babbling; blue light; brainstem evoked response audiometry; case report; clinical article; conduction deafness; cranial nerve paralysis; dyspnea; ear malformation; electrophysiological response; face asymmetry; face deformity; Goldenhar syndrome; hearing; hearing disorder; hearing examination; hearing function; heart atrium septum defect; heart disease; heart ventricle septum defect; hemifacial microsomia; human; hyperbilirubinemia; infant; lagophthalmos; loud noise; male; micrognathia; microtia; motor development; nuclear magnetic resonance imaging; parasystolic murmur; perception deafness; ptosis (eyelid); radiodiagnosis; speech development; speech therapy |
Malaysian Medical Association |
03005283 |
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34806693 |
Article |
Q4 |
193 |
19818 |
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108 |
Liberty I.A., Kodim N., Sartika R.A.D., Trihandini I., Tjekyan R.M.S., Zulkarnain, Pane M., Pratisthita L.B., Tahapary D.L., Soewondo P. |
57211435130;57210444174;41862490800;8449988100;57267287700;57267073300;55831164800;57221504201;55944492500;23475336100; |
Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011–2016) |
2021 |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
15 |
6 |
102280 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115349587&doi=10.1016%2fj.dsx.2021.102280&partnerID=40&md5=db55d7f5dcad157ad5a355acd19a0c89 |
Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Department of Public Nutrition, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Department of Biostatistics, Public Health Faculty Universitas Indonesia, Depok, Indonesia; National Institute Health Research and Development, Ministry of Health of the Republic of Indonesia, Indonesia; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Universitas Indonesia Hospital, Depok, Indonesia; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Liberty, I.A., Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia, Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Kodim, N., Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Sartika, R.A.D., Department of Public Nutrition, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Trihandini, I., Department of Biostatistics, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Tjekyan, R.M.S., Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Zulkarnain, Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Pane, M., National Institute Health Research and Development, Ministry of Health of the Republic of Indonesia, Indonesia; Pratisthita, L.B., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Universitas Indonesia Hospital, Depok, Indonesia; Tahapary, D.L., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background and aims: Reproductive-aged women are prone to type 2 diabetes mellitus. This study aims to evaluate the optimal cut off point of Triglyceride/Glucose Index for predicting glucose status conversion among women of reproductive age. Methods: This study involved normoglycemic and prediabetes women aged 20–49 years from the Bogor Non-Communicable Diseases Cohort Study (West Java, Indonesia) conducted from 2011 to 2016. Statistical analysis was performed using Receiver Operating Characteristics curve analysis with STATA version 15. Results: Among prediabetes subjects (n = 371), the cut-off point of TyG index for regression from prediabetes to normoglycemic subjects was <4.51 [sensitivity, specificity, AUC (95%CI) 83.9%, 80.1%, 0.913 (0.875–0.943), respectively] and the cut-off point for progression from prediabetes to diabetes was >4.54 [80.0%, 73.1%, 0.858 (0.807–0.900)]. Among normoglycemic subjects (n = 1300), the cut-off point of TyG index for progression to prediabetes and diabetes were >4.44 [80.1%, 71.1%, 0.834 (0.812–0.854)] and >4.47 [80.6%, 80.8%, 0.909 (0.890–0.926)] respectively. Conclusion: Based on sample of subjects evaluated between 2011 and 2016, TyG index appears to be a promising marker for glucose status conversion among reproductive-aged women in Jakarta, Indonesia. © 2021 |
Conversion; Glucose; Reproductive; TyG index; Women |
biological marker; cholesterol; glucose; hemoglobin A1c; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; adult; Article; cholesterol blood level; cohort analysis; controlled study; data analysis software; diabetes mellitus; evaluation study; female; follow up; glucose blood level; groups by age; human; impaired glucose tolerance; Indonesia; major clinical study; middle aged; oral glucose tolerance test; outcome assessment; predictive value; receiver operating characteristic; reference value; remission; reproduction; retrospective study; sensitivity and specificity; statistical analysis; triacylglycerol blood level; triglyceride glucose index; young adult |
Elsevier Ltd |
18714021 |
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34562866 |
Article |
Q2 |
684 |
7304 |
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110 |
Abdullah M., Sukartini N., Nursyirwan S.A., Pribadi R.R., Maulahela H., Utari A.P., Muzellina V.N., Wiraatmadja A., Renaldi K. |
7103393434;6505680329;57249143800;57194732282;57189612709;57113585900;57223968527;57249709700;57190963547; |
Gut Microbiota Profiles in Early-and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future |
2021 |
Digestion |
102 |
6 |
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823 |
832 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114428104&doi=10.1159%2f000516689&partnerID=40&md5=b8c0c7b633dbb180aa40d5f20e5481d7 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Abdullah, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sukartini, N., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pribadi, R.R., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Utari, A.P., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Muzellina, V.N., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Wiraatmadja, A., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Renaldi, K., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background: Researchers believe the role of gut microbiota dysbiosis in the raised incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be associated with microbiota dysbiosis either dependently or independently (combined with other risk factors). Summary: Recently, the rising of incidence and mortality of EOCRC have been noted. Some researchers are looking for risk factors influencing this fact. They hypothesize that it may be because of microbiota dysbiosis. Microbiota dysbiosis has been known to promote cancer development through immunity dysregulation and chronic inflammation. Microbiomes profile in late-onset colorectal cancer (LOCRC) among older patients has been documented, but there is still lack of data about microbial profiles among younger colorectal cancer (CRC) patients. This review tries to explain microbial profiles differences between EOCRC and LOCRC as a potential diagnostic biomarker in the future, and whether microbiota can have a role in EOCRC genesis. Key Messages: Microbiota does vary with age, and EOCRC may be associated with colonization of some specific bacteria. Further studies about gut microbiota profiles in EOCRC and LOCRC may provide a new insight on diagnostic biomarker of CRC. © 2021 S. Karger AG, Basel. Copyright: All rights reserved. |
Colorectal cancer; Diagnostic biomarker; Early-onset colorectal cancer; Gut microbiota; Microbiota dysbiosis |
biological marker; colorectal tumor; dysbiosis; human; incidence; intestine flora; Biomarkers; Colorectal Neoplasms; Dysbiosis; Gastrointestinal Microbiome; Humans; Incidence |
S. Karger AG |
00122823 |
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34433172 |
Review |
Q2 |
882 |
5279 |
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173 |
Forrat R., Dayan G.H., DiazGranados C.A., Bonaparte M., Laot T., Capeding M.R., Sanchez L., Coronel D.L., Reynales H., Chansinghakul D., Hadinegoro S.R.S., Perroud A.P., Frago C., Zambrano B., Machabert T., Wu Y., Luedtke A., Price B., Vigne C., Haney O., Savarino S.J., Bouckenooghe A., Noriega F. |
36339272700;6701860993;56721307400;56614799700;24471016000;6602161242;57201082261;56418742600;55343075300;29067671300;56893685800;57198777256;56255310300;7801355579;57201364463;57215829074;54395741500;57002517700;57192890936;57215866119;57220410062;18233281300;7005980306; |
Analysis of Hospitalized and Severe Dengue Cases Over the 6 years of Follow-up of the Tetravalent Dengue Vaccine (CYD-TDV) Efficacy Trials in Asia and Latin America |
2021 |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
73 |
6 |
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1003 |
1012 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116958578&doi=10.1093%2fcid%2fciab288&partnerID=40&md5=cceec1a946e6b236b138dcb4bb663855 |
Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile, France; Clinical Sciences Sanofi PasteurPA, United States; Translation Sciences and Biomarkers, Sanofi PasteurPA, United States; Global Clinical Science, Sanofi Pasteur, Taguig City, Philippines; Research Institute for Tropical Medicine, Medical Department, Muntinlupa, Philippines; Clinical Sciences, Sanofi PasteurMexico City, Mexico; Centro de Atencion e Investigación Médica, Bogotá, Colombia; Research & Development, Sanofi PasteurBangkok, Thailand; Cipto Mangunkusumo Hospital, University of IndonesiaJakarta, Indonesia; Clinical Sciences, Sanofi Pasteur, São Paulo, Brazil; Clinical Sciences, Sanofi Pasteur, Singapore; Clinical Sciences, Sanofi Pasteur, Uruguay; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Global Pharmacovigilance, Sanofi PasteurPA, United States |
Forrat, R., Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile, France; Dayan, G.H., Clinical Sciences Sanofi PasteurPA, United States; DiazGranados, C.A., Clinical Sciences Sanofi PasteurPA, United States; Bonaparte, M., Translation Sciences and Biomarkers, Sanofi PasteurPA, United States; Laot, T., Global Clinical Science, Sanofi Pasteur, Taguig City, Philippines; Capeding, M.R., Research Institute for Tropical Medicine, Medical Department, Muntinlupa, Philippines; Sanchez, L., Global Clinical Science, Sanofi Pasteur, Taguig City, Philippines; Coronel, D.L., Clinical Sciences, Sanofi PasteurMexico City, Mexico; Reynales, H., Centro de Atencion e Investigación Médica, Bogotá, Colombia; Chansinghakul, D., Research & Development, Sanofi PasteurBangkok, Thailand; Hadinegoro, S.R.S., Cipto Mangunkusumo Hospital, University of IndonesiaJakarta, Indonesia; Perroud, A.P., Clinical Sciences, Sanofi Pasteur, São Paulo, Brazil; Frago, C., Clinical Sciences, Sanofi Pasteur, Singapore; Zambrano, B., Clinical Sciences, Sanofi Pasteur, Uruguay; Machabert, T., Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile, France; Wu, Y., Clinical Sciences Sanofi PasteurPA, United States; Luedtke, A., Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Price, B., Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Vigne, C., Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile, France; Haney, O., Global Pharmacovigilance, Sanofi PasteurPA, United States; Savarino, S.J., Translation Sciences and Biomarkers, Sanofi PasteurPA, United States; Bouckenooghe, A., Clinical Sciences, Sanofi Pasteur, São Paulo, Brazil; Noriega, F., Clinical Sciences Sanofi PasteurPA, United States |
BACKGROUND: CYD-TDV, a live, attenuated, tetravalent dengue vaccine, has been approved for the prevention of symptomatic dengue in previously dengue exposed individuals. This post hoc analysis assessed hospitalized and severe virologically confirmed dengue (VCD) over the complete 6-year follow-up of 3 CYD-TDV efficacy studies (CYD14, CYD15, and CYD23/CYD57). METHODS: The main outcomes were hazard ratios (HRs) for hospitalized or severe VCD by baseline dengue serostatus, focusing on those who were seropositive, and by age at immunization (<9 years/≥9 years). Baseline dengue serostatus was measured or inferred using several methods. Hospitalized VCD cases were characterized in terms of clinical signs and symptoms and wild-type viremia level. Antibody persistence was assessed up to 5 years after the last injection. RESULTS: In those aged ≥9 years and baseline seropositive, CYD-TDV protected against hospitalized and severe VCD over 6 years compared to placebo (HR [95% confidence interval] multiple imputation from month 0 method, .19 [.12-.30] and .15 [.06-.39]; other methods were consistent). Vaccine protection was observed over the different study periods, being highest during the first 2 years. Evidence for a decreased risk of hospitalized and severe VCD was also observed in seropositive participants aged 6-8 years. Clinical signs and symptoms, and quantified dengue viremia from participants with hospitalized VCD were comparable between groups. CONCLUSIONS: CYD-TDV demonstrated robust protection against hospitalized and severe VCD over the entire 6-year follow-up in participants who were seropositive and ≥9 years old. Protection was also observed in seropositive 6-8 year-olds. Clinical Trials Registration: NCT00842530, NCT01983553, NCT01373281, NCT01374516. © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. |
CYD-TDV; dengue; serostatus; VCD |
dengue vaccine; live vaccine; vaccine; virus antibody; Asia; child; controlled study; dengue; Dengue virus; follow up; human; randomized controlled trial; severe dengue; South and Central America; Antibodies, Viral; Asia; Child; Dengue; Dengue Vaccines; Dengue Virus; Follow-Up Studies; Humans; Latin America; Severe Dengue; Vaccines, Attenuated; Vaccines, Combined |
NLM (Medline) |
15376591 |
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33822015 |
Article |
Q1 |
3440 |
518 |
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194 |
Mansyur M. |
37085506800; |
Occupational health, productivity and evidence-based workplace health intervention |
2021 |
Acta Medica Philippina |
55 |
6 |
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602 |
603 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116680924&doi=10.47895%2fAMP.V55I6.4273&partnerID=40&md5=e8cf11e83c91edd4e2dccb08e749b070 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia |
Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia |
[No abstract available] |
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University of the Philippines Manila |
00016071 |
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Editorial |
Q4 |
128 |
25603 |
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195 |
Habiburrahman M., Lesmana E., Harmen F., Gratia N., Mirtha L.T. |
57320844200;57208440285;57288593800;57288763400;57193201450; |
The impact of sleep deprivation on work performance towards night-shift healthcare workers: An evidence-based case report |
2021 |
Acta Medica Philippina |
55 |
6 |
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650 |
664 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116676334&doi=10.47895%2fAMP.V55I6.3157&partnerID=40&md5=279c9c6f812ba7d9e6cf09363847268d |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hospital of Universitas Indonesia, Depok, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lesmana, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harmen, F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gratia, N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mirtha, L.T., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Hospital of Universitas Indonesia, Depok, Indonesia |
Background. Poor sleep and excessive fatigue among workers can reduce well-being and physical fitness. However, not many studies have mentioned how sleeping deprivation among night-shift healthcare workers impacted their work performance in multiple aspects. Method. We conducted an evidence-based case report (EBCR) of a night shift nurse who was worried about the impact of her sleep deprivation on her work performance in the future due to prior history of needle-stick injuries. We aimed to determine whether sleeping deprivation caused by regular night shifts leads to decreased work performance among night-shift healthcare workers by formulating a clinical question. Evidence was searched systematically using five major journal databases (Proquest, EBSCO-Host, PubMed, ScienceDirect, and Cochrane) and was assessed thoroughly using inclusion and exclusion criteria. Results. Eleven eligible studies were obtained with a medium level of evidence (III-IV), three systematic reviews with meta-analyses (SR-MA), three SR without MA, and five observational studies. All of them were analyzed and critically appraised using Oxford Evidence-Based Medicine and Joanna Briggs Institute tools. We found that reduced quantity and quality of sleep impacted all dimensions of work performance among healthcare professionals, be it in task performance (e.g., skill proficiency), contextual performance (e.g., communication skill and mental health issues), and patient and health worker safety (accident and medication error). It could also encourage counterproductive work behavior, such as absenteeism. Furthermore, sleep deprivation changes circadian rhythms, causing decreased information processing and affective recognition functions in some vital brain areas, ultimately affecting several work dimensions. Conclusion. In conclusion, stakeholders need to adjust proper shift scheduling for health care workers, practice sleep hygiene, maintain physical fitness, and consume nutritional food, positively correlated to health and productivity. © 2021 University of the Philippines Manila. All rights reserved. |
Evidence-based medicine; Healthcare worker; Night shift; Sleep deprivation; Work performance |
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University of the Philippines Manila |
00016071 |
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Article |
Q4 |
128 |
25603 |
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196 |
Alie I.R., Andriantoro H., Timan I.S., Sulistomo A.W., Illyas E.I., Mansyur M. |
57288933200;55037171500;6602793366;57024018500;57288423500;37085506800; |
Potency biomarker effect of endothelial microparticles (emps) for early prediction of cardiovascular risk in shift worker nurses |
2021 |
Acta Medica Philippina |
55 |
6 |
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616 |
620 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116671512&doi=10.47895%2fAMP.V55I6.3142&partnerID=40&md5=10ceaf9c58aabc0ce93083d831644fe1 |
Program of Universitas Indonesia; Department of Cardiology and Vascular Faculty of Medicine, Universitas Indonesia; Department of Pathology Clinic, Faculty of Medicine, Universitas Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia; Department of Physiology, Faculty of Medicine, Universitas Indonesia |
Alie, I.R., Program of Universitas Indonesia; Andriantoro, H., Department of Cardiology and Vascular Faculty of Medicine, Universitas Indonesia; Timan, I.S., Department of Pathology Clinic, Faculty of Medicine, Universitas Indonesia; Sulistomo, A.W., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia; Illyas, E.I., Department of Physiology, Faculty of Medicine, Universitas Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia |
Objectives. Shift work results in changing worker's behavior, food, and sleep patterns, which can cause circadian rhythm disturbance, which is a cardiovascular risk. Until now, a biomarker of early prediction of cardiovascular risk on shift workers is still not developed. This study aimed to assess the cardiovascular risk of shift worker nurses by detecting endothelial microparticles (EMPs). Methods. This longitudinal study compared six shift nurses and five non-shift nurses by measuring the EMPs using antigen CD31+ flow cytometry. All met the inclusion criteria consisting of 28 blood samples followed in one week shift. Results. EMPs among non-shift nurses were below 200 μL. However, shift nurses' EMPs increased above 200 μL with Man-Whitney U p = 0.000 on days 4 and 7 following a one shift per week schedule. Conclusion. There was an increase in shift workers' endothelial microparticles (EMP) which was a sign of cardiovascular risk. © 2021 University of the Philippines Manila. All rights reserved. |
Cardiovascular risk; CD31+; Endothelial microparticles (EMPs); Nurse; Shift work |
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University of the Philippines Manila |
00016071 |
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Article |
Q4 |
128 |
25603 |
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332 |
Faisal H.K.P., Taufik F.F., Sugihen T.T.G., Prasenohadi, Juliani T., Yunus F. |
57216393050;57193061752;57226081615;55758911100;57226064151;57194486277; |
Brief psychotic disorder in COVID-19 patient with no history of mental illness |
2021 |
Journal of Infection in Developing Countries |
15 |
6 |
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787 |
790 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110348248&doi=10.3855%2fjidc.14830&partnerID=40&md5=12676e465ecf6e71d13eea343a7e6c3f |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Department of Psychiatry, Persahabatan Hospital, Jakarta, Indonesia |
Faisal, H.K.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Taufik, F.F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Sugihen, T.T.G., Department of Psychiatry, Persahabatan Hospital, Jakarta, Indonesia; Prasenohadi, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Juliani, T., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia |
Introduction: COVID-19 pandemic affects mental health globally. Reports showed the increase of mental illness as a response to the COVID-19 pandemic. However, the correlation between the COVID-19 and mental illness is not fully understood yet. Methodology: We reported a brief psychotic disorder in a COVID-19 patient with no history of mental illness who was hospitalized in Persahabatan Hospital, Jakarta, Indonesia. Results: Psychotic symptoms appeared five days after COVID-19 onset and laboratory tests showed elevated levels of d-dimer and fibrinogen. Conclusions: Elevated levels of d-dimer and fibrinogen suggest an ongoing COVID-19-associated coagulopathy that might cause a microdamage in the central nervous system. It might contribute to the manifestation of psychotic symptoms. The correlation between brief psychotic disorder and COVID-19 requires further investigation. Copyright © 2021 Faisal et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Acute psychosis; Brief psychotic disorder; COVID-19; Neuropsychiatry |
alanine aminotransferase; amlodipine; ascorbic acid; aspartate aminotransferase; azithromycin; bicarbonate; C reactive protein; creatinine; D dimer; enoxaparin; ferritin; hemoglobin; hydroxychloroquine; lorazepam; oseltamivir; potassium; risperidone; sodium; urea; vitamin D; fibrin degradation product; fibrin fragment D; fibrinogen; activated partial thromboplastin time; adult; Article; auditory hallucination; blood carbon dioxide tension; blood oxygen tension; brief psychotic disorder; case report; clinical article; cold sweat; computer assisted tomography; coronavirus disease 2019; diarrhea; dry cough; dyspnea; glucose blood level; human; hypertension; lymphocyte count; male; medical history; middle aged; nasopharyngeal swab; neutrophil count; platelet count; prothrombin time; reverse tr |
Journal of Infection in Developing Countries |
20366590 |
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34242187 |
Article |
Q3 |
322 |
14136 |
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|
338 |
SITOHANG I.B.S., SOEBARYO R.W., KANOKO M. |
56734569200;6506868173;6507911148; |
Acne lesion extraction versus oral doxycycline for moderate acne vulgaris: A randomized clinical trial |
2021 |
Journal of Clinical and Aesthetic Dermatology |
14 |
6 |
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E61 |
E65 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113565099&partnerID=40&md5=84d3ad669270477356a8236dc4266b13 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
SITOHANG, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; SOEBARYO, R.W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; KANOKO, M., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Acne vulgaris is a polymorphic skin condition comprising inflamed and noninflamed lesions. In addition to topical retinoids, systemic antibiotics play a role as a main therapy for acne with inflamed papules and cysts. However, due to the increasing tendency for bacterial resistance, alternatives to antibiotics are needed. OBJECTIVE: The aim of this study was to evaluate the effectiveness of acne lesion extraction compared to oral doxycycline for moderate acne vulgaris and to explore the impact of both treatments on Hypoxia-inducible factor (HIF)-1 alpha. METHODS: This randomized clinical trial was conducted in two teaching hospitals in 2016. Subjects with moderate acne vulgaris (N=140) were divided into two groups. Each subject in both groups received 0.05% tretinoin cream, applied to the entire face each night, and 2.5% benzoyl peroxide gel, applied to the acne lesions in the morning and afternoon. One group was also treated with oral doxycycline 100mg once daily and the other was treated with acne lesion extraction performed on all facial lesions every two weeks; the patients were evaluated via patient-reported self-assessment and lesion counts every two weeks for six weeks. HIF-1 alpha expression of the biopsied lessions was examined via immunohistochemistry. RESULTS: 128 subjects completed the study. Among these 128 subjects there was a prominent decrease in inflamed lesions at Week 6 in the lesion extraction group compared to the oral doxycycline group (p<0.05). HIF-1 alpha expression of the biopsied lesions was found in 7 of 9 samples taken from the oral doxycycline group, while 3 of 4 samples in the lesion extraction group were found negative. CONCLUSION: According to our results, acne lesion extraction appeared to be more effective than oral doxycycline in treating this sample of patients with moderate acne vulgaris. Additionally, HIF-1 alpha expression appeared to be decreased after acne lesion extraction. © 2021 Matrix Medical Communications. All rights reserved. |
Acne lesion extraction; Hypoxia-inducible factor-1 alpha; Moderate acne vulgaris; Oral doxycycline |
benzoyl peroxide; doxycycline; hypoxia inducible factor 1alpha; retinoic acid; acne vulgaris; adult; Article; clinical evaluation; comparative effectiveness; controlled study; disease severity; extraction; face; female; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; night; protein expression; randomized controlled trial; self evaluation |
Matrix Medical Communications |
19412789 |
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Article |
Q2 |
600 |
8425 |
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