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No records
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355 |
Purwoningsih E., Pawitan J.A. |
57224985986;6508348067; |
Mesenchymal stem cells: Potential application in covid-19 patients with acute respiratory distress syndrome (ards) |
2021 |
International Medical Journal |
28 |
3 |
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303 |
306 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108812441&partnerID=40&md5=0feffaf110f53271a8fb3d884ed44c7c |
Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Purwoningsih, E., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Objective: To highlight the potential of mesenchymal stem cells (MSCs) as an adjuvant therapy for severe COVID-19 patient. Materials and Methods: We searched Pubmed and Google Scholar, using keywords: 'MSC AND lung injury', 'MSC AND ARDS', 'MSC AND COVID-19', 'Stem cell AND Lung injury' and 'Stem cell AND ARDS', on 19 Mei and 19 July 2020. Results and Discussions: Severe manifestations in COVID-19 patients are due to immune system response. MSCs have immunomodulatory and anti-inflammatory effect and therefore may be beneficial to alleviate acute respiratory distress syndrome (ARDS). A small published study showed that MSCs had beneficial effect on COVID-19 patients, who showed clinical symptom improvements. Further, application of MSCs from several sources such as bone marrow, menstrual blood, and umbilical cord-derived MSCs, which were used in patients suffering from lung injury/ARDS due to conditions other than COVID-19, showed that a dose of up to 1.0 x 107 cells/kg body weight was well tolerated. Conclusion: administration of MSCs to COVID-19 patients showed improvement in clinical symptoms, and a dose up to 1.0 x 107 cells/kg body weight showed tolerance in ARDS patients with moderate to severe conditions. However, the results came from studies with small number of patients, so the results need to be interpreted with caution, and more well design studies with a larger number of patients are needed. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Coronavirus; COVID-19; Mesenchymal stem cell; Stem cells |
alpha interferon; angiopoietin; angiotensin converting enzyme 2; beta interferon; bradykinin; C reactive protein; cytokine; gamma interferon inducible protein 10; granulocyte colony stimulating factor; interferon; interleukin 1; interleukin 10; interleukin 13; interleukin 1beta; interleukin 2 receptor; interleukin 4; interleukin 6; keratinocyte growth factor; monocyte chemotactic protein 1; receptor binding domain; toll like receptor; transmembrane protease serine 2; tumor necrosis factor; unclassified drug; vasculotropin; viral protein; virus spike protein; adjuvant therapy; adult respiratory distress syndrome; angiogenesis; Article; B lymphocyte; CD8+ T lymphocyte; cell differentiation; coronavirus disease 2019; cytokine storm; dendritic cell; exosome; genetic transcription; human; immun |
Japan International Cultural Exchange Foundation |
13412051 |
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Article |
Q4 |
183 |
20490 |
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357 |
Yuniar I. |
57222295046; |
Restrictive versus liberal fluid bolus therapy in septic shock children: An evidence-based case report |
2021 |
Critical Care and Shock |
24 |
3 |
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143 |
152 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108644226&partnerID=40&md5=42389d8b506d8b4bbacd5ec1431f9c34 |
Division of Pediatric Emergency and Hospitalization, Departement of Child Health, dr. Cipto, Mangunkusumo General Hospital, Faculty of Medicine, University of Indonesia, Indonesia |
Yuniar, I., Division of Pediatric Emergency and Hospitalization, Departement of Child Health, dr. Cipto, Mangunkusumo General Hospital, Faculty of Medicine, University of Indonesia, Indonesia |
Fluid bolus therapy (FBT) is one of prime management in early goal-directed therapy (EGDT) to achieve adequate cardiac output. The Fluid Expansion as Supportive Therapy (FEAST) tri-al, a randomized-clinical trial that was used as an evidence to support fluid resuscitation rec-ommendation in Surviving Sepsis Campaign (SSC) 2020, must be discontinued because of . increasing mortality in the group that received higher volume of FBT. We present a case of a 9-year-old girl, 15 kg, came to emergency ward with refractory septic shock and became fluid overload after the second FBT. This proceeding aimed to deliver evidence-based case practice if the comparison between liberal versus restrictive FBT in children with septic shock. © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved. |
Fluid; Liberal; Pediatric; Restrictive; Resuscitation; Shock |
cefotaxime; dobutamine; furosemide; oxygen; paracetamol; procalcitonin; Ringer lactate solution; vasoactive agent; Article; case report; child; clinical article; comparative effectiveness; drug dose titration; dyspnea; early goal-directed therapy; emergency ward; evidence based practice; female; fluid bolus therapy; fluid resuscitation; forward heart failure; heart afterload; heart muscle contractility; heart preload; hemodynamic monitoring; human; hypervolemia; hypotension; hypovolemic shock; mortality; pediatric intensive care unit; pericardial effusion; school child; septic shock; tachycardia |
The Indonesian Foundation of Critical Care Medicine |
14107767 |
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Article |
Q4 |
134 |
24890 |
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363 |
Yo E.C., Witjaksono A.N., Fitriani D.Y., Werdhani R.A., Parikesit D. |
57213188908;57224351398;57224589606;57189088848;57163830300; |
Assessing webinar outcomes for health professionals: A perspective from Indonesia during coronavirus disease 2019 pandemic |
2021 |
Korean Journal of Medical Education |
33 |
2 |
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87 |
96 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107416703&doi=10.3946%2fKJME.2021.190&partnerID=40&md5=0cbaa0d20d5fdaa64a279a62d1943b06 |
Faculty of Medicine, Universitas Indonesia, Indonesia; Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universita Indonesia, Depok, Indonesia; Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia; Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Universitas Indonesia Hospital, Pondok Cina, Beji, Depok City, West Java, 16424, Indonesia |
Yo, E.C., Faculty of Medicine, Universitas Indonesia, Indonesia; Witjaksono, A.N., Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Fitriani, D.Y., Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universita Indonesia, Depok, Indonesia, Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia, Universitas Indonesia Hospital, Pondok Cina, Beji, Depok City, West Java, 16424, Indonesia; Parikesit, D., Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Purpose: With the ongoing coronavirus disease 2019 (COVID-19) pandemic, health institutions and hospitals are increasingly relying on e-learning for continuing education. However, in many countries there is still limited data on the effectiveness of online learning particularly in the healthcare field. This study aims to evaluate whether webinar as a form of online educational intervention is satisfactory and effective for the continuing education of health professionals in Indonesia. Methods: We collected participants' demographic information including health profession, place of work, work unit, and year of graduation. There were six independent webinars included in this study. Webinar outcomes included satisfaction and learning scores. Regarding satisfaction, participants were told to complete a satisfaction survey and asked whether they would recommend the webinar to their colleagues. Regarding learning, information on their mean pre-test and post-test scores was collected. Results: A total of 3,607 health professionals were enrolled, with the highest participation in webinars about emergency cases and COVID-19 management. The response towards satisfaction was overwhelmingly positive. In all six webinars, post-test scores were statistically significantly higher than pre-test scores. Recently graduated physicians scored higher in learning than senior physicians, while place of work and work unit did not significantly affect the scores. Conclusion: The use of webinar for health professionals training in Indonesia was well-received amid the ongoing pandemic. In the future, health institutions and teaching hospitals should optimize the implementation of webinar training as it is associated with low cost, high flexibility, and less time commuting. © 2021 Korean Journal of Medical Education. All Rights Reserved. |
Continuing education; Covid-19; Health occupations; Online learning; Videoconferencing |
continuing education; cost benefit analysis; disease management; education; health care personnel; human; Indonesia; learning; pandemic; physician; procedures; satisfaction; teaching; teaching hospital; Cost-Benefit Analysis; COVID-19; Disease Management; Education, Continuing; Education, Distance; Educational Measurement; Health Personnel; Hospitals, Teaching; Humans; Indonesia; Learning; Pandemics; Personal Satisfaction; Physicians; SARS-CoV-2; Teaching |
Korean Society of Medical Education |
2005727X |
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34062640 |
Article |
Q4 |
175 |
21057 |
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371 |
Solichin I., Prabowo I., Laras S., Putra N.H.D., Rhatomy S. |
57202813479;57221098612;57221107761;57223369199;57204509883; |
Early ambulatory Duchenne muscular dystrophy: First symptomatic stage of ambulation - A case report |
2021 |
International Journal of Surgery Open |
33 |
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100349 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105724819&doi=10.1016%2fj.ijso.2021.100349&partnerID=40&md5=63b5fb970c994ebc6ab98bdfa879fb05 |
Department of Orthopaedics and Traumatology, Purwokerto Orthopaedics Hospital, Purwokerto, Central Java, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sport and Adult Reconstruction Division, Department of Orthopaedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia; Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Solichin, I., Department of Orthopaedics and Traumatology, Purwokerto Orthopaedics Hospital, Purwokerto, Central Java, Indonesia; Prabowo, I., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Laras, S., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, N.H.D., Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rhatomy, S., Sport and Adult Reconstruction Division, Department of Orthopaedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Introduction and importance: Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease, affected male at young age, progressive and deteriorating symptoms followed the age and usually died in age 20. The early sign of DMD or early ambulatory DMD appeared lately after walking age, and progressively deteriorated by the time of aging. Case presentation: A 9 years old boy with symptoms of waddling gait, toe walking and difficulty to climb the stairs came to our center to seek medical help. He initially walked with assistance at 18 months, but always fell down when he tried to walk for distance. No family history of developmental delay. He still has the ability to stand up after sitting on the floor and run even with the difficulty. Behavioral problem or academic achievement was according to his age. The way he did to get down the stairs, he had to sit down and the get back up when he finished. His parents’ status of economic and education is low, which brought them difficult to understand their child is in suffer. Clinical discussion: The diagnosis and staging of DMD are quite challenging. A consistency and knowledge to gathered all the information related to history, symptoms, and signs provided the qualified data to overcome the complexity of the case, and to managed the spectrum of the disease appropriately, thus avoid the unnecessary treatment. The symptomatic stage of DMD is distinguished by the spectrum of ambulation. The effective and efficacy of the treatment are depending on good clinical assessment of neuromuscular function. Multidisciplinary team to diagnose and manage the case was needed to create to solve the problem became easier. Conclusion: The early ambulatory DMD is the first symptomatic early warning signs to treat DMD. The oral corticosteroids believed could mainstay the functional outcome the upper limb, avoid severe scoliosis, and maintain the respiratory function as normal as possible. Occupational and physical therapies were proposed to maintain the good quality of life. © 2021 The Author(s) |
Duchenne muscular dystrophy; Early ambulatory; Waddling gait |
methylprednisolone; academic achievement; Article; case report; child; clinical article; clinical assessment; daily life activity; Duchenne muscular dystrophy; gestational age; human; male; mobilization; multidisciplinary team; neuromuscular function; physical examination; physiotherapist; physiotherapy; priority journal; problem behavior; running; school child; waddling gait; walking |
Elsevier Ltd |
24058572 |
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Article |
Q4 |
187 |
20224 |
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396 |
Raharjo S.B., Chandranegara A.F., Hanafy D.A., Yamin M., Rasyid H.E., Haryadi, Rizal A., Ardhianto P., Hermanto D.Y., Yuniadi Y., OneAF Investigators |
57017880700;57224571328;55431326800;23475706300;57224560676;57224559936;57218771291;57208782791;57223816091;57155066100; |
Indonesian registry on atrial fibrillation (OneAF) |
2021 |
Medicine |
100 |
19 |
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e25725 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107981983&doi=10.1097%2fMD.0000000000025725&partnerID=40&md5=c16e93c69fd23a59227c9462d518a9c8 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Pasar Rebo General Hospital; Department of Internal Medicine Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Department of Cardiology, Faculty of Medicine, alas University, Djamil General Hospital, Padang, West Sumatra, Indonesia; Eka Hospital, Pekanbaru, Riau, Indonesia; Department of Cardiology, Faculty of Medicine, Brawijaya University, Syaiful Anwar General Hospital, Malang, Indonesia; Department of Cardiology, Faculty of Medicine, Diponegoro University, Kariadi General Hospital, Semarang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia |
Raharjo, S.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Chandranegara, A.F., Pasar Rebo General Hospital; Hanafy, D.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Yamin, M., Department of Internal Medicine Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Rasyid, H.E., Department of Cardiology, Faculty of Medicine, alas University, Djamil General Hospital, Padang, West Sumatra, Indonesia; Haryadi, Eka Hospital, Pekanbaru, Riau, Indonesia; Rizal, A., Department of Cardiology, Faculty of Medicine, Brawijaya University, Syaiful Anwar General Hospital, Malang, Indonesia; Ardhianto, P., Department of Cardiology, Faculty of Medicine, Diponegoro University, Kariadi General Hospital, Semarang, Indonesia; Hermanto, D.Y., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia; Yuniadi, Y., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia; OneAF Investigators |
BACKGROUND: Data on the optimal therapeutic international normalized ratio (INR) for non-valvular and valvular atrial fibrillation (AF) in Indonesia is currently unavailable. Therefore, we designed the Indonesian Registry on Atrial Fibrillation (OneAF) registry in order to seek a safe and beneficial range of INR in Indonesian patients with non-valvular and valvular AF. METHODS/DESIGN: The OneAF registry is a nationwide collaboration of the Indonesian Heart Rhythm Society (InaHRS) enrolling all hospitals with cardiac electrophysiologists in Indonesia. It is a prospective, multicentre, nationwide, observational study aiming to recruit non-valvular and valvular AF patients in Indonesia. The registry was started in January 2020 with a planned 2 years of recruitment. There are 2 respondents for this registry: non-cohort and cohort respondents. Non-cohort registry respondents are AF patients at hospitals who fulfill inclusion and exclusion criteria but did not consent for a 24 month follow up. Whereas patients who consented for a 24 month follow up were included as cohort registry respondents. Key data collected includes basic sociodemographic information, symptoms and signs, medical history, results of physical examination and laboratory test, details of diagnostics and treatment measures and events. RESULTS: Currently, a total of 1568 respondents have been enrolled in the non-cohort registry, including 1065 respondents with non-valvular AF (67.8%) and 503 respondents with valvular AF (32.2%). We believe that the OneAF registry will provide insight into the regional variability of anticoagulant treatment for AF, the implementation of rhythm/rate control approaches, and the clinical outcomes concerning cardiocerebrovascular events. TRIAL REGISTRATION: Registered at clinicaltrials.gov (NCT04222868). Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. |
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adolescent; adult; aged; atrial fibrillation; clinical trial; female; human; Indonesia; male; middle aged; multicenter study; prospective study; register; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Female; Humans; Indonesia; Male; Middle Aged; Prospective Studies; Registries; Young Adult |
NLM (Medline) |
15365964 |
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34106597 |
Article |
Q4 |
204 |
19087 |
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439 |
Restuti R., Sriyana A., Priyono H., Saleh R. |
55261428300;57203022550;57201550021;57391850200; |
Postauricular Cutaneous Mastoid Fistula Closure with Combination of Bilobed Flap and Fibro-Muscular-Periosteal Flap: A Case Series |
2021 |
Indian Journal of Otology |
27 |
2 |
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116 |
119 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122022487&doi=10.4103%2findianjotol.indianjotol_10_21&partnerID=40&md5=dfd65407309ade3f15f32833b03bb0ef |
Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Restuti, R., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Sriyana, A., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Priyono, H., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Saleh, R., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Chronic suppurative otitis media (CSOM) with cholesteatoma can present with intratemporal complications such as postauricular subperiosteal abscess with or without fistula. In some postauricular cutaneous mastoid fistula cases, direct closure of the wound is not possible due to skin tension, leading to skin necrosis and postoperative recurrent cutaneous fistula. Here, we describe a surgical technique using a combination of a bilobed flap and a fibro-muscular-periosteal flap for fistula closure on a 31-year-old and a 35-year-old female with postauricular cutaneous mastoid fistula due to CSOM. All patients were successfully managed with no fistula recurrence. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Bilobed flap; cholesteatoma; chronic suppurative otitis media; postauricular cutaneous mastoid fistula |
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Wolters Kluwer Medknow Publications |
09717749 |
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Article |
Q4 |
174 |
21127 |
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440 |
Rinaldhy K., Yani A., Tamba R.P. |
57325189500;57215433374;47761736600; |
Papaverine for the prevention of anastomosis leakage after intussusception management in rat model |
2021 |
Surgical Chronicles |
26 |
2 |
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162 |
164 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118534016&partnerID=40&md5=b67121e208a15e9402e0b83764f168b7 |
Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia |
Rinaldhy, K., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia; Yani, A., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia; Tamba, R.P., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia |
Background. The most common complication of surgical management for intussusception is anastomosis leakage. Warm normal saline application, especially on the bowel with a doubtful viability, is thought to cause vasodilation and subsequently reduce the resected bowel requirement. This research compared the effect of topical warm normal saline and papaverine on collagen grading and incidence of anastomosis leakage of the intussusception model in rats. Methods. Ileo-ileal intussusception was created on 21 Sprague-Dawley rats. Groups included control group, normal saline group, and papaverine group. Intussusceptions were then reduced and given topical warm normal saline or papaverine according to each group. Afterward, each bowel was resected, and an end-to-end anastomosis was created. After five days, laparotomy was performed to assess anastomosis leakages. Moreover, a collagen grading assessment was performed on the anastomosis. Results. The papaverine group had the highest collagen grade and no anastomosis leakage. There was no significant association between treatments and the incidence of anastomosis leakage (p=0.174), but treatments were significantly associated with collagen grade (p=0.014). Collagen grade was significantly associated with anastomosis leakage (p=0.01). Conclusion. Findings suggested that the topical application of papaverine is associated with an increase in collagen grading and higher collagen grade is associated with a decrease of anastomosis leakage. © 2021 Surgical Society of Northern Greece. All rights reserved. |
Anastomosis leakage; Collagen; Intussusception; Normal saline; Papaverine. |
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Surgical Society of Northern Greece |
11085002 |
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Article |
Q4 |
102 |
30883 |
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441 |
Sukmawati D., Junaidi H., Syaidah R. |
55615650900;57202926303;55418885900; |
Human platelet-rich plasma as a biological stimulant for proliferation and differentiation of mesenchymal stem cells |
2021 |
Biomedicine (India) |
41 |
2 |
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168 |
173 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117427828&doi=10.51248%2f.v41i2.777&partnerID=40&md5=08fabc44956a1de6990d42feb38813ba |
Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia |
Sukmawati, D., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Junaidi, H., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia; Syaidah, R., Department of Histology, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jln. Salemba Raya No.4, Jakarta, 10430, Indonesia |
Platelet is one of the cells within the blood that have potential in regenerative therapy. Recently platelet-related products got special attention due to the abundance of growth factors and easy availability and processing. With the robust in cell-based therapy, platelet-rich plasma (PRP) has been intensively studied for its potential to substitute the fetal bovine serum (FBS) as the supplement in cell culture. Our study aimed to investigate the use of human PRP in mesenchymal stem cells (MSC) culture and its related effect on stem cell biology. We searched in vitro studies that used human PRP as a supplementing factor on human MSCs culture. From the initial 172 studies, 14 studies fulfilled the selection criteria and were analysed. The results showed that the sources of MSCs were varied, including adipose tissue, bone marrow, and dental tissue. The PRP concentration showing the best effects was ranged from 10 to 20%. In addition, most of the studies demonstrated the superiority of PRP to FBS in promoting the proliferation and differentiation of MSCs in vitro. Therefore, PRP could be an alternative to FBS in supporting a xeno-free culture system. Studies are needed to reveal the mechanism of PRP in maintaining the physiology of MSCs. © 2021, Indian Association of Biomedical Scientists. All rights reserved. |
Cell culture; Differentiation; Mesenchymal stem cells; Platelet-rich plasma; Proliferation; Xeno-free |
adipose tissue; Article; bone marrow; cell differentiation; cell proliferation; controlled study; human; human cell; in vitro study; mesenchymal stem cell; thrombocyte rich plasma; tooth tissue; xeno-free culture |
Indian Association of Biomedical Scientists |
09702067 |
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Article |
Q4 |
106 |
29384 |
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442 |
Legiawati L., Raissa, Santoso I.D., Lubis F.F. |
57202804484;57240272100;57219513443;57239954700; |
Comparison between clinical diagnosis with and without dermoscopy in the assessment of hair disorders |
2021 |
Journal of Pakistan Association of Dermatologists |
31 |
2 |
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201 |
205 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113937212&partnerID=40&md5=c56b73079d0a2b354502f693b7d4fa6e |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Tarumanegara, Jakarta, Indonesia |
Legiawati, L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Raissa, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Santoso, I.D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Tarumanegara, Jakarta, Indonesia; Lubis, F.F., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background: Hair dermoscopy or trichoscopy is a tool used to find hair abnormalities more clearly. Morphologic feature of skin and hair abnormalities becomes more visible under this tool compared with naked eye. It helps to diagnose hair disorders faster and can be used for follow up treatment in patients. The purpose of this study is to compare superiority between clinical diagnosis alone and with addition of dermoscopy tool in the assessment of hair disease. Methods: Research was conducted in October 2018 in a boarding school in West Java, Indonesia. This was a cross-sectional descriptive study. Statistical analysis was done using SPSS Statistics 20.0. Data were collected from 127 subjects through anamnesis, general physical examination and dermatological findings, pull test, dermoscopy, and photographs of scalp and hair lesions. Results: The highest incidence of hair disorder in this study found by clinical examination and dermoscopy was pediculosis capitis, with a total of 86 subjects (67.7%). From the comparison between clinical examination and dermoscopy, we found that dermoscopy was superior for diagnosis. As much as 43 cases of hair disorders which were not detected on clinical examination screening were found by dermoscopy. Out of 127 children, there were 49 subjects with hair disorders found in clinical examination and 92 subjects found by dermoscopy. Conclusion: Dermoscopy as a non-invasive tool which plays an important role in determining the diagnosis of hair disorder. © 2021 Pakistan Association of Dermatologists. All rights reserved. |
Dermoscopy; Diagnosis; Hair disease; Lice infestations; Pediculosis capitis |
adolescent; alopecia; Article; child; clinical examination; controlled study; cross-sectional study; descriptive research; epiluminescence microscopy; female; hair; hair disease; human; Indonesia; major clinical study; male; pediculosis capitis; scar; sebaceous nevus; seborrheic dermatitis |
Pakistan Association of Dermatologists |
15609014 |
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Article |
Q4 |
129 |
25503 |
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453 |
Yani A., Dorothy D., Amaliah R. |
57215433374;57224003330;57224001785; |
Influence of Intestinal Strangulation Release on Ischemiareperfusion Injury in Sprague Dawley Rats |
2021 |
Annals of African Surgery |
18 |
2 |
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95 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106736281&doi=10.4314%2fAAS.V18I2.6&partnerID=40&md5=611bcf09b29bda5c9a4b2e09279bdd15 |
Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yani, A., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Dorothy, D., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Amaliah, R., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: In intestinal ischemia, reperfusion towards the injured intestine can cause further injury to the intestine itself and to remote organs. This research aimed to evaluate the influence of intestinal strangulation release (SR) before resection on the intestine outside margin of the strangulated intestine compared with subjects without intestinal strangulation release (WSR). Methods: Fourteen male Sprague Dawley rats were subjected to strangulation of one loop of the distal ileum for 4 h. In the SR group, the strangulated intestine was released for 5 min and then resected for necrotic parts. In the WSR group, the strangulated intestine was immediately resected WSR. The control group received a sham laparotomy. Four hours after the second laparotomy, the animals were sacrificed, and intestinal samples were taken for histomorphological analysis and measurement of intestinal malondialdehyde (MDA) level. Results: The injury on the histomorphological intestinal mucosa and intestinal MDA level were insignificantly higher in the SR group than in the WSR group (p>0.05). Conclusion: Intestinal SR before resection causes more tissue injury and oxidative stress on the intestine outside the strangulation section, but the difference is not statistically significant. © 2021 Surgical Society of Kenya. All rights reserved. |
Intestinal ischemia; Intestinal strangulation release; Intestine injury; Ischemia-reperfusion injury; Malondialdehyde |
ketamine; malonaldehyde; xylazine; animal experiment; animal model; animal tissue; Article; controlled study; histopathology; ileum; intestinal strangulation; intestine injury; intestine ischemia; intestine necrosis; laparotomy; male; nonhuman; oxidative stress; rat; reperfusion injury; sham procedure; small intestine obstruction; small intestine resection; Sprague Dawley rat |
Surgical Society of Kenya |
19999674 |
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Q4 |
114 |
27851 |
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